{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q05329","secondaryAccessions":["Q9UD87"],"uniProtkbId":"DCE2_HUMAN","entryAudit":{"firstPublicDate":"1996-02-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1996-02-01","entryVersion":202,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Glutamate decarboxylase 2"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"8999827"}],"value":"4.1.1.15"}]},"alternativeNames":[{"fullName":{"value":"65 kDa glutamic acid decarboxylase"},"shortNames":[{"value":"GAD-65"}]},{"fullName":{"value":"Glutamate decarboxylase 65 kDa isoform"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:4093"}],"value":"GAD2"},"synonyms":[{"value":"GAD65"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"8999827"}],"value":"Catalyzes the production of GABA"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-glutamate + H(+) = 4-aminobutanoate + CO2","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:17785"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:16526"},{"database":"ChEBI","id":"CHEBI:29985"},{"database":"ChEBI","id":"CHEBI:59888"}],"ecNumber":"4.1.1.15","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"8999827"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:17786"},"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"8999827"}]}]},{"commentType":"COFACTOR","cofactors":[{"name":"pyridoxal 5'-phosphate","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17384644"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:597326"}}]},{"commentType":"BIOPHYSICOCHEMICAL PROPERTIES","kineticParameters":{"michaelisConstants":[{"constant":2.15,"unit":"mM","substrate":"glutamate","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8999827"}]}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10775108"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17384644"}],"value":"Homodimer"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q05329","intActId":"EBI-9304251"},"interactantTwo":{"uniProtKBAccession":"Q8WTS1","geneName":"ABHD5","intActId":"EBI-2813554"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q05329","intActId":"EBI-9304251"},"interactantTwo":{"uniProtKBAccession":"Q6RW13","geneName":"AGTRAP","intActId":"EBI-741181"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q05329","intActId":"EBI-9304251"},"interactantTwo":{"uniProtKBAccession":"Q6RW13-2","geneName":"AGTRAP","intActId":"EBI-11522760"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q05329","intActId":"EBI-9304251"},"interactantTwo":{"uniProtKBAccession":"P55056","geneName":"APOC4","intActId":"EBI-18302142"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q05329","intActId":"EBI-9304251"},"interactantTwo":{"uniProtKBAccession":"Q3SXY8","geneName":"ARL13B","intActId":"EBI-11343438"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q05329","intActId":"EBI-9304251"},"interactantTwo":{"uniProtKBAccession":"Q15041","geneName":"ARL6IP1","intActId":"EBI-714543"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q05329","intActId":"EBI-9304251"},"interactantTwo":{"uniProtKBAccession":"Q5T9G4-2","geneName":"ARMC12","intActId":"EBI-36513937"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q05329","intActId":"EBI-9304251"},"interactantTwo":{"uniProtKBAccession":"Q8WZ55","geneName":"BSND","intActId":"EBI-7996695"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q05329","intActId":"EBI-9304251"},"interactantTwo":{"uniProtKBAccession":"Q06432","geneName":"CACNG1","intActId":"EBI-9686780"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q05329","intActId":"EBI-9304251"},"interactantTwo":{"uniProtKBAccession":"Q96DZ9","geneName":"CMTM5","intActId":"EBI-2548702"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q05329","intActId":"EBI-9304251"},"interactantTwo":{"uniProtKBAccession":"Q96DZ9-2","geneName":"CMTM5","intActId":"EBI-11522780"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q05329","intActId":"EBI-9304251"},"interactantTwo":{"uniProtKBAccession":"Q7Z7G2","geneName":"CPLX4","intActId":"EBI-18013275"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q05329","intActId":"EBI-9304251"},"interactantTwo":{"uniProtKBAccession":"Q8N8Q1","geneName":"CYB561D1","intActId":"EBI-12873482"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q05329","intActId":"EBI-9304251"},"interactantTwo":{"uniProtKBAccession":"Q9BUN8","geneName":"DERL1","intActId":"EBI-398977"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q05329","intActId":"EBI-9304251"},"interactantTwo":{"uniProtKBAccession":"Q96Q80","geneName":"DERL3","intActId":"EBI-12831318"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q05329","intActId":"EBI-9304251"},"interactantTwo":{"uniProtKBAccession":"Q6ZPD8","geneName":"DGAT2L6","intActId":"EBI-12831978"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q05329","intActId":"EBI-9304251"},"interactantTwo":{"uniProtKBAccession":"Q6E0U4","geneName":"DMKN","intActId":"EBI-7943171"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q05329","intActId":"EBI-9304251"},"interactantTwo":{"uniProtKBAccession":"Q8N9I5","geneName":"FADS6","intActId":"EBI-3943864"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q05329","intActId":"EBI-9304251"},"interactantTwo":{"uniProtKBAccession":"Q9NRY5","geneName":"FAM114A2","intActId":"EBI-10973142"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q05329","intActId":"EBI-9304251"},"interactantTwo":{"uniProtKBAccession":"Q96GL9","geneName":"FAM163A","intActId":"EBI-11793142"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q05329","intActId":"EBI-9304251"},"interactantTwo":{"uniProtKBAccession":"A8MV81","geneName":"HIGD1C","intActId":"EBI-12809676"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q05329","intActId":"EBI-9304251"},"interactantTwo":{"uniProtKBAccession":"Q96B96","geneName":"LDAF1","intActId":"EBI-7055862"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q05329","intActId":"EBI-9304251"},"interactantTwo":{"uniProtKBAccession":"Q9H400","geneName":"LIME1","intActId":"EBI-2830566"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q05329","intActId":"EBI-9304251"},"interactantTwo":{"uniProtKBAccession":"Q969L2","geneName":"MAL2","intActId":"EBI-944295"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q05329","intActId":"EBI-9304251"},"interactantTwo":{"uniProtKBAccession":"Q5EB52","geneName":"MEST","intActId":"EBI-1050204"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q05329","intActId":"EBI-9304251"},"interactantTwo":{"uniProtKBAccession":"Q9HC36","geneName":"MRM3","intActId":"EBI-1045440"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q05329","intActId":"EBI-9304251"},"interactantTwo":{"uniProtKBAccession":"Q96AL5","geneName":"PBX3","intActId":"EBI-741171"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q05329","intActId":"EBI-9304251"},"interactantTwo":{"uniProtKBAccession":"O60664","geneName":"PLIN3","intActId":"EBI-725795"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q05329","intActId":"EBI-9304251"},"interactantTwo":{"uniProtKBAccession":"Q8IZV5","geneName":"RDH10","intActId":"EBI-11913715"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q05329","intActId":"EBI-9304251"},"interactantTwo":{"uniProtKBAccession":"Q6ZWK4","geneName":"RHEX","intActId":"EBI-18304046"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q05329","intActId":"EBI-9304251"},"interactantTwo":{"uniProtKBAccession":"Q9NS64","geneName":"RPRM","intActId":"EBI-1052363"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q05329","intActId":"EBI-9304251"},"interactantTwo":{"uniProtKBAccession":"O15126","geneName":"SCAMP1","intActId":"EBI-954338"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q05329","intActId":"EBI-9304251"},"interactantTwo":{"uniProtKBAccession":"Q8N3Y7","geneName":"SDR16C5","intActId":"EBI-3923480"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q05329","intActId":"EBI-9304251"},"interactantTwo":{"uniProtKBAccession":"Q96IW7","geneName":"SEC22A","intActId":"EBI-8652744"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q05329","intActId":"EBI-9304251"},"interactantTwo":{"uniProtKBAccession":"O60906","geneName":"SMPD2","intActId":"EBI-12828299"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q05329","intActId":"EBI-9304251"},"interactantTwo":{"uniProtKBAccession":"Q9NZD8","geneName":"SPG21","intActId":"EBI-742688"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q05329","intActId":"EBI-9304251"},"interactantTwo":{"uniProtKBAccession":"Q6PIF2","geneName":"SYCE2","intActId":"EBI-11958386"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q05329","intActId":"EBI-9304251"},"interactantTwo":{"uniProtKBAccession":"O43761","geneName":"SYNGR3","intActId":"EBI-11321949"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q05329","intActId":"EBI-9304251"},"interactantTwo":{"uniProtKBAccession":"A0PK00","geneName":"TMEM120B","intActId":"EBI-10171534"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q05329","intActId":"EBI-9304251"},"interactantTwo":{"uniProtKBAccession":"Q5BJH2-2","geneName":"TMEM128","intActId":"EBI-10694905"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q05329","intActId":"EBI-9304251"},"interactantTwo":{"uniProtKBAccession":"Q9UBN6","geneName":"TNFRSF10D","intActId":"EBI-1044859"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q05329","intActId":"EBI-9304251"},"interactantTwo":{"uniProtKBAccession":"Q86UF1","geneName":"TSPAN33","intActId":"EBI-12045841"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"value":"Associated to cytoplasmic vesicles. In neurons, cytosolic leaflet of Golgi membranes and presynaptic clusters"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12356867"}],"value":"Cytoplasm, cytosol","id":"SL-0091"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12356867"}],"value":"Cytoplasmic vesicle","id":"SL-0088"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12356867"}],"value":"Presynaptic cell membrane","id":"SL-0222"},"topology":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12356867"}],"value":"Lipid-anchor","id":"SL-9901"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12356867"}],"value":"Golgi apparatus membrane","id":"SL-0134"},"topology":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12356867"}],"value":"Peripheral membrane protein","id":"SL-9903"},"orientation":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12356867"}],"value":"Cytoplasmic side","id":"SL-9910"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8999827"}],"value":"Phosphorylated; which does not affect kinetic parameters or subcellular location"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12356867"}],"value":"Palmitoylated; which is required for presynaptic clustering"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the group II decarboxylase family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"CAA49554.1","note":"Extended N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":585,"modifier":"EXACT"}},"description":"Glutamate decarboxylase 2","featureId":"PRO_0000146968"},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":24,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":14,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Binding site","location":{"start":{"value":181,"modifier":"EXACT"},"end":{"value":183,"modifier":"EXACT"}},"description":"","ligand":{"name":"substrate"}},{"type":"Binding site","location":{"start":{"value":558,"modifier":"EXACT"},"end":{"value":558,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17384644"}],"ligand":{"name":"substrate"}},{"type":"Modified residue","location":{"start":{"value":3,"modifier":"EXACT"},"end":{"value":3,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8999827"}]},{"type":"Modified residue","location":{"start":{"value":6,"modifier":"EXACT"},"end":{"value":6,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8999827"}]},{"type":"Modified residue","location":{"start":{"value":10,"modifier":"EXACT"},"end":{"value":10,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8999827"}]},{"type":"Modified residue","location":{"start":{"value":13,"modifier":"EXACT"},"end":{"value":13,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8999827"}]},{"type":"Modified residue","location":{"start":{"value":396,"modifier":"EXACT"},"end":{"value":396,"modifier":"EXACT"}},"description":"N6-(pyridoxal phosphate)lysine"},{"type":"Lipidation","location":{"start":{"value":30,"modifier":"EXACT"},"end":{"value":30,"modifier":"EXACT"}},"description":"S-palmitoyl cysteine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12356867"}]},{"type":"Lipidation","location":{"start":{"value":45,"modifier":"EXACT"},"end":{"value":45,"modifier":"EXACT"}},"description":"S-palmitoyl cysteine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12356867"}]},{"type":"Natural variant","location":{"start":{"value":12,"modifier":"EXACT"},"end":{"value":12,"modifier":"EXACT"}},"description":"in dbSNP:rs8190591","featureCrossReferences":[{"database":"dbSNP","id":"rs8190591"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.4"}],"featureId":"VAR_018821","alternativeSequence":{"originalSequence":"G","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":124,"modifier":"EXACT"},"end":{"value":124,"modifier":"EXACT"}},"description":"in dbSNP:rs8190600","featureCrossReferences":[{"database":"dbSNP","id":"rs8190600"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.4"}],"featureId":"VAR_018822","alternativeSequence":{"originalSequence":"K","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":153,"modifier":"EXACT"},"end":{"value":153,"modifier":"EXACT"}},"description":"in dbSNP:rs2839672","featureCrossReferences":[{"database":"dbSNP","id":"rs2839672"}],"featureId":"VAR_029176","alternativeSequence":{"originalSequence":"P","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":232,"modifier":"EXACT"},"end":{"value":232,"modifier":"EXACT"}},"description":"in dbSNP:rs2839673","featureCrossReferences":[{"database":"dbSNP","id":"rs2839673"}],"featureId":"VAR_029177","alternativeSequence":{"originalSequence":"G","alternativeSequences":["E"]}},{"type":"Natural variant","location":{"start":{"value":286,"modifier":"EXACT"},"end":{"value":286,"modifier":"EXACT"}},"description":"in dbSNP:rs8190671","featureCrossReferences":[{"database":"dbSNP","id":"rs8190671"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.4"}],"featureId":"VAR_018823","alternativeSequence":{"originalSequence":"K","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":326,"modifier":"EXACT"},"end":{"value":326,"modifier":"EXACT"}},"description":"in dbSNP:rs2839678","featureCrossReferences":[{"database":"dbSNP","id":"rs2839678"}],"featureId":"VAR_029178","alternativeSequence":{"originalSequence":"G","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":375,"modifier":"EXACT"},"end":{"value":375,"modifier":"EXACT"}},"description":"in dbSNP:rs8190730","featureCrossReferences":[{"database":"dbSNP","id":"rs8190730"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.4"}],"featureId":"VAR_018824","alternativeSequence":{"originalSequence":"R","alternativeSequences":["Q"]}},{"type":"Mutagenesis","location":{"start":{"value":3,"modifier":"EXACT"},"end":{"value":13,"modifier":"EXACT"}},"description":"No effect on glutamate decarboxylase activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8999827"}],"alternativeSequence":{"originalSequence":"SPGSGFWSFGS","alternativeSequences":["APGAGFWAFGA"]}},{"type":"Helix","location":{"start":{"value":89,"modifier":"EXACT"},"end":{"value":91,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OKK"}]},{"type":"Helix","location":{"start":{"value":94,"modifier":"EXACT"},"end":{"value":96,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OKK"}]},{"type":"Helix","location":{"start":{"value":104,"modifier":"EXACT"},"end":{"value":126,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OKK"}]},{"type":"Helix","location":{"start":{"value":138,"modifier":"EXACT"},"end":{"value":144,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OKK"}]},{"type":"Helix","location":{"start":{"value":153,"modifier":"EXACT"},"end":{"value":155,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OKK"}]},{"type":"Helix","location":{"start":{"value":156,"modifier":"EXACT"},"end":{"value":169,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OKK"}]},{"type":"Beta strand","location":{"start":{"value":178,"modifier":"EXACT"},"end":{"value":183,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OKK"}]},{"type":"Helix","location":{"start":{"value":188,"modifier":"EXACT"},"end":{"value":200,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OKK"}]},{"type":"Turn","location":{"start":{"value":207,"modifier":"EXACT"},"end":{"value":209,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OKK"}]},{"type":"Helix","location":{"start":{"value":211,"modifier":"EXACT"},"end":{"value":228,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OKK"}]},{"type":"Helix","location":{"start":{"value":231,"modifier":"EXACT"},"end":{"value":233,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OKK"}]},{"type":"Beta strand","location":{"start":{"value":235,"modifier":"EXACT"},"end":{"value":242,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OKK"}]},{"type":"Helix","location":{"start":{"value":243,"modifier":"EXACT"},"end":{"value":258,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OKK"}]},{"type":"Helix","location":{"start":{"value":262,"modifier":"EXACT"},"end":{"value":265,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OKK"}]},{"type":"Helix","location":{"start":{"value":267,"modifier":"EXACT"},"end":{"value":269,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OKK"}]},{"type":"Beta strand","location":{"start":{"value":273,"modifier":"EXACT"},"end":{"value":278,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OKK"}]},{"type":"Helix","location":{"start":{"value":284,"modifier":"EXACT"},"end":{"value":291,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OKK"}]},{"type":"Helix","location":{"start":{"value":296,"modifier":"EXACT"},"end":{"value":298,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OKK"}]},{"type":"Beta strand","location":{"start":{"value":299,"modifier":"EXACT"},"end":{"value":302,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OKK"}]},{"type":"Helix","location":{"start":{"value":312,"modifier":"EXACT"},"end":{"value":324,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OKK"}]},{"type":"Beta strand","location":{"start":{"value":328,"modifier":"EXACT"},"end":{"value":337,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OKK"}]},{"type":"Turn","location":{"start":{"value":339,"modifier":"EXACT"},"end":{"value":341,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OKK"}]},{"type":"Helix","location":{"start":{"value":347,"modifier":"EXACT"},"end":{"value":357,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OKK"}]},{"type":"Beta strand","location":{"start":{"value":360,"modifier":"EXACT"},"end":{"value":365,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OKK"}]},{"type":"Helix","location":{"start":{"value":368,"modifier":"EXACT"},"end":{"value":373,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OKK"}]},{"type":"Turn","location":{"start":{"value":375,"modifier":"EXACT"},"end":{"value":377,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OKK"}]},{"type":"Helix","location":{"start":{"value":378,"modifier":"EXACT"},"end":{"value":381,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OKK"}]},{"type":"Helix","location":{"start":{"value":384,"modifier":"EXACT"},"end":{"value":386,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OKK"}]},{"type":"Beta strand","location":{"start":{"value":388,"modifier":"EXACT"},"end":{"value":392,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OKK"}]},{"type":"Beta strand","location":{"start":{"value":405,"modifier":"EXACT"},"end":{"value":411,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OKK"}]},{"type":"Helix","location":{"start":{"value":414,"modifier":"EXACT"},"end":{"value":419,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OKK"}]},{"type":"Helix","location":{"start":{"value":435,"modifier":"EXACT"},"end":{"value":437,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OKK"}]},{"type":"Helix","location":{"start":{"value":440,"modifier":"EXACT"},"end":{"value":442,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OKK"}]},{"type":"Helix","location":{"start":{"value":452,"modifier":"EXACT"},"end":{"value":486,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OKK"}]},{"type":"Beta strand","location":{"start":{"value":491,"modifier":"EXACT"},"end":{"value":497,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OKK"}]},{"type":"Beta strand","location":{"start":{"value":500,"modifier":"EXACT"},"end":{"value":502,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OKK"}]},{"type":"Beta strand","location":{"start":{"value":504,"modifier":"EXACT"},"end":{"value":508,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OKK"}]},{"type":"Turn","location":{"start":{"value":511,"modifier":"EXACT"},"end":{"value":515,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OKK"}]},{"type":"Helix","location":{"start":{"value":523,"modifier":"EXACT"},"end":{"value":526,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OKK"}]},{"type":"Helix","location":{"start":{"value":529,"modifier":"EXACT"},"end":{"value":540,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OKK"}]},{"type":"Beta strand","location":{"start":{"value":544,"modifier":"EXACT"},"end":{"value":550,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OKK"}]},{"type":"Beta strand","location":{"start":{"value":553,"modifier":"EXACT"},"end":{"value":559,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OKK"}]},{"type":"Helix","location":{"start":{"value":568,"modifier":"EXACT"},"end":{"value":581,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OKK"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0968","category":"Cellular component","name":"Cytoplasmic vesicle"},{"id":"KW-0210","category":"Molecular function","name":"Decarboxylase"},{"id":"KW-0333","category":"Cellular component","name":"Golgi apparatus"},{"id":"KW-0449","category":"PTM","name":"Lipoprotein"},{"id":"KW-0456","category":"Molecular function","name":"Lyase"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0530","category":"Biological process","name":"Neurotransmitter biosynthesis"},{"id":"KW-0564","category":"PTM","name":"Palmitate"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-0663","category":"Ligand","name":"Pyridoxal phosphate"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0770","category":"Cellular component","name":"Synapse"}],"references":[{"referenceNumber":1,"citation":{"id":"1924293","citationType":"journal article","authors":["Karlsen A.E.","Hagopian W.A.","Grubin C.E.","Dube S.","Disteche C.M.","Adler D.A.","Barmeier H.","Mathewes S.","Grant F.J.","Foster D.","Lernmark A."],"citationCrossReferences":[{"database":"PubMed","id":"1924293"},{"database":"DOI","id":"10.1073/pnas.88.19.8337"}],"title":"Cloning and primary structure of a human islet isoform of glutamic acid decarboxylase from chromosome 10.","publicationDate":"1991","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"8337","lastPage":"8341","volume":"88"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"],"referenceComments":[{"value":"Pancreatic islet","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"1549570","citationType":"journal article","authors":["Bu D.-F.","Erlander M.G.","Hitz B.C.","Tillakaratne N.J.","Kaufman D.L.","Wagner-Mcpherson C.B.","Evans G.A.","Tobin A.J."],"citationCrossReferences":[{"database":"PubMed","id":"1549570"},{"database":"DOI","id":"10.1073/pnas.89.6.2115"}],"title":"Two human glutamate decarboxylases, 65-kDa GAD and 67-kDa GAD, are each encoded by a single gene.","publicationDate":"1992","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"2115","lastPage":"2119","volume":"89"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"]},{"referenceNumber":3,"citation":{"id":"8088791","citationType":"journal article","authors":["Bu D.-F.","Tobin A.J."],"citationCrossReferences":[{"database":"PubMed","id":"8088791"},{"database":"DOI","id":"10.1006/geno.1994.1246"}],"title":"The exon-intron organization of the genes (GAD1 and GAD2) encoding two human glutamate decarboxylases (GAD67 and GAD65) suggests that they derive from a common ancestral GAD.","publicationDate":"1994","journal":"Genomics","firstPage":"222","lastPage":"228","volume":"21"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"]},{"referenceNumber":4,"citation":{"id":"CI-9GALB6QA9R6OH","citationType":"submission","authoringGroup":["NIEHS SNPs program"],"publicationDate":"JUL-2003","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]","VARIANTS ARG-12; ASN-124; ARG-286 AND GLN-375"]},{"referenceNumber":5,"citation":{"id":"7680313","citationType":"journal article","authors":["Mauch L.","Abney C.C.","Berg H.","Scherbaum W.A.","Liedvogel B.","Northemann W."],"citationCrossReferences":[{"database":"PubMed","id":"7680313"},{"database":"DOI","id":"10.1111/j.1432-1033.1993.tb17698.x"}],"title":"Characterization of a linear epitope within the human pancreatic 64-kDa glutamic acid decarboxylase and its autoimmune recognition by sera from insulin-dependent diabetes mellitus patients.","publicationDate":"1993","journal":"Eur. J. Biochem.","firstPage":"597","lastPage":"603","volume":"212"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF 6-585"],"referenceComments":[{"value":"Pancreas","type":"TISSUE"}]},{"referenceNumber":6,"citation":{"id":"8243826","citationType":"journal article","authors":["Kim J.","Richter W.","Aanstoot H.-J.","Shi Y.","Fu Q.","Rajotte R.","Warnock G.","Baekkeskov S."],"citationCrossReferences":[{"database":"PubMed","id":"8243826"},{"database":"DOI","id":"10.2337/diab.42.12.1799"}],"title":"Differential expression of GAD65 and GAD67 in human, rat, and mouse pancreatic islets.","publicationDate":"1993","journal":"Diabetes","firstPage":"1799","lastPage":"1808","volume":"42"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF 245-585"]},{"referenceNumber":7,"citation":{"id":"8999827","citationType":"journal article","authors":["Namchuk M.","Lindsay L.","Turck C.W.","Kanaani J.","Baekkeskov S."],"citationCrossReferences":[{"database":"PubMed","id":"8999827"},{"database":"DOI","id":"10.1074/jbc.272.3.1548"}],"title":"Phosphorylation of serine residues 3, 6, 10, and 13 distinguishes membrane anchored from soluble glutamic acid decarboxylase 65 and is restricted to glutamic acid decarboxylase 65alpha.","publicationDate":"1997","journal":"J. Biol. Chem.","firstPage":"1548","lastPage":"1557","volume":"272"},"referencePositions":["PHOSPHORYLATION AT SER-3; SER-6; SER-10 AND SER-13","BIOPHYSICOCHEMICAL PROPERTIES","CATALYTIC ACTIVITY","FUNCTION","MUTAGENESIS OF 3-SER--SER-13"]},{"referenceNumber":8,"citation":{"id":"12356867","citationType":"journal article","authors":["Kanaani J.","El-Din El-Husseini A.","Aguilera-Moreno A.","Diacovo J.M.","Bredt D.S.","Baekkeskov S."],"citationCrossReferences":[{"database":"PubMed","id":"12356867"},{"database":"DOI","id":"10.1083/jcb.200205053"}],"title":"A combination of three distinct trafficking signals mediates axonal targeting and presynaptic clustering of GAD65.","publicationDate":"2002","journal":"J. Cell Biol.","firstPage":"1229","lastPage":"1238","volume":"158"},"referencePositions":["SUBCELLULAR LOCATION","PALMITOYLATION AT CYS-30 AND CYS-45"]},{"referenceNumber":9,"citation":{"id":"10775108","citationType":"journal article","authors":["Corper A.L.","Stratmann T.","Apostolopoulos V.","Scott C.A.","Garcia K.C.","Kang A.S.","Wilson I.A.","Teyton L."],"citationCrossReferences":[{"database":"PubMed","id":"10775108"},{"database":"DOI","id":"10.1126/science.288.5465.505"}],"title":"A structural framework for deciphering the link between I-Ag7 and autoimmune diabetes.","publicationDate":"2000","journal":"Science","firstPage":"505","lastPage":"511","volume":"288"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 222-235 IN COMPLEX WITH MHC"]},{"referenceNumber":10,"citation":{"id":"17384644","citationType":"journal article","authors":["Fenalti G.","Law R.H.P.","Buckle A.M.","Langendorf C.","Tuck K.","Rosado C.J.","Faux N.G.","Mahmood K.","Hampe C.S.","Banga J.P.","Wilce M.","Schmidberger J.","Rossjohn J.","El-Kabbani O.","Pike R.N.","Smith A.I.","Mackay I.R.","Rowley M.J.","Whisstock J.C."],"citationCrossReferences":[{"database":"PubMed","id":"17384644"},{"database":"DOI","id":"10.1038/nsmb1228"}],"title":"GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop.","publicationDate":"2007","journal":"Nat. Struct. Mol. Biol.","firstPage":"280","lastPage":"286","volume":"14"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 88-584 IN COMPLEX WITH SUBSTRATE","SUBUNIT","COFACTOR"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"M81882","properties":[{"key":"ProteinId","value":"AAA62367.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"M74826","properties":[{"key":"ProteinId","value":"AAA58491.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AY340073","properties":[{"key":"ProteinId","value":"AAP88040.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"X69936","properties":[{"key":"ProteinId","value":"CAA49554.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"M70435","properties":[{"key":"ProteinId","value":"AAA52513.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS7149.1","properties":[{"key":"Description","value":"-"}]},{"database":"PIR","id":"A41935","properties":[{"key":"EntryName","value":"A41292"}]},{"database":"RefSeq","id":"NP_000809.1","properties":[{"key":"NucleotideSequenceId","value":"NM_000818.3"}]},{"database":"RefSeq","id":"NP_001127838.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001134366.2"}]},{"database":"PDB","id":"1ES0","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.60 A"},{"key":"Chains","value":"B=207-220"}]},{"database":"PDB","id":"2OKK","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"A=88-584"}]},{"database":"PDB","id":"7LZ6","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"7.30 A"},{"key":"Chains","value":"A/B=88-584"}]},{"database":"PDBsum","id":"1ES0","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2OKK","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7LZ6","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"Q05329","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-23603","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q05329","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"108846","properties":[{"key":"Interactions","value":"47"}]},{"database":"ComplexPortal","id":"CPX-3033","properties":[{"key":"EntryName","value":"Glutamate decarboxylase 2 complex"}]},{"database":"ComplexPortal","id":"CPX-3065","properties":[{"key":"EntryName","value":"Glutamate decarboxylase 1/2 complex"}]},{"database":"DIP","id":"DIP-29293N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q05329","properties":[{"key":"Number of interactors","value":"602"}]},{"database":"IntAct","id":"Q05329","properties":[{"key":"Interactions","value":"41"}]},{"database":"NDEx","id":"IQUERY-CP-GAD2","properties":[{"key":"Evidences","value":"10 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000365437","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL2952","properties":[{"key":"Description","value":"-"}]},{"database":"DrugBank","id":"DB00142","properties":[{"key":"GenericName","value":"Glutamic acid"}]},{"database":"DrugBank","id":"DB00114","properties":[{"key":"GenericName","value":"Pyridoxal phosphate"}]},{"database":"iPTMnet","id":"Q05329","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q05329","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"Q05329","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"GAD2","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"1352216","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q05329","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q05329","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000365437","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q05329","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"58319","properties":[{"key":"Description","value":"-"}]},{"database":"ABCD","id":"Q05329","properties":[{"key":"antibodies","value":"12 sequenced antibodies"}]},{"database":"Antibodypedia","id":"3635","properties":[{"key":"antibodies","value":"789 antibodies from 46 providers"}]},{"database":"DNASU","id":"2572","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000259271.7","properties":[{"key":"ProteinId","value":"ENSP00000259271.3"},{"key":"GeneId","value":"ENSG00000136750.13"}]},{"database":"Ensembl","id":"ENST00000376261.8","properties":[{"key":"ProteinId","value":"ENSP00000365437.3"},{"key":"GeneId","value":"ENSG00000136750.13"}]},{"database":"GeneID","id":"2572","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:2572","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000376261.8","properties":[{"key":"ProteinId","value":"ENSP00000365437.3"},{"key":"RefSeqNucleotideId","value":"NM_001134366.2"},{"key":"RefSeqProteinId","value":"NP_001127838.1"}]},{"database":"AGR","id":"HGNC:4093","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA28508","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"2572","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"2572","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"GAD2","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:4093","properties":[{"key":"GeneName","value":"GAD2"}]},{"database":"HPA","id":"ENSG00000136750","properties":[{"key":"ExpressionPatterns","value":"Tissue enriched (brain)"}]},{"database":"MIM","id":"138275","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000136750","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000136750","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG0629","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000157951","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_011856_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q05329","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"AGMVIFK","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"392571at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q05329","properties":[{"key":"Number of GO annotations","value":"4 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q05329","properties":[{"key":"Description","value":"-"}]},{"database":"BioCyc","id":"MetaCyc:HS06208-MONOMER","properties":[{"key":"Description","value":"-"}]},{"database":"BRENDA","id":"4.1.1.15","properties":[{"key":"OrganismId","value":"2681"}]},{"database":"PathwayCommons","id":"Q05329","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-888568","properties":[{"key":"PathwayName","value":"GABA synthesis"}]},{"database":"Reactome","id":"R-HSA-888590","properties":[{"key":"PathwayName","value":"GABA synthesis, release, reuptake and degradation"}]},{"database":"Reactome","id":"R-HSA-9022927","properties":[{"key":"PathwayName","value":"MECP2 regulates transcription of genes involved in GABA signaling"}]},{"database":"SABIO-RK","id":"Q05329","properties":[{"key":"Description","value":"-"}]},{"database":"SignaLink","id":"Q05329","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"Q05329","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000136750","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"2572","properties":[{"key":"hits","value":"12 hits in 1152 CRISPR screens"}]},{"database":"ChiTaRS","id":"GAD2","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"Q05329","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"GAD2","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"2572","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q05329","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:Q05329","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 10"}]},{"database":"RNAct","id":"Q05329","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000136750","properties":[{"key":"ExpressionPatterns","value":"Expressed in islet of Langerhans and 90 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q05329","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0030424","properties":[{"key":"GoTerm","value":"C:axon"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0061202","properties":[{"key":"GoTerm","value":"C:clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0000139","properties":[{"key":"GoTerm","value":"C:Golgi membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0042734","properties":[{"key":"GoTerm","value":"C:presynaptic membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0004351","properties":[{"key":"GoTerm","value":"F:glutamate decarboxylase activity"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0030170","properties":[{"key":"GoTerm","value":"F:pyridoxal phosphate binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0007268","properties":[{"key":"GoTerm","value":"P:chemical synaptic transmission"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"8954991"}]},{"database":"GO","id":"GO:0009449","properties":[{"key":"GoTerm","value":"P:GABA biosynthetic process"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0006540","properties":[{"key":"GoTerm","value":"P:GABA shunt"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"CDD","id":"cd06450","properties":[{"key":"EntryName","value":"DOPA_deC_like"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.640.10:FF:000016","properties":[{"key":"EntryName","value":"Glutamate decarboxylase like 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.90.1150.170","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.640.10","properties":[{"key":"EntryName","value":"Type I PLP-dependent aspartate aminotransferase-like (Major domain)"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR002129","properties":[{"key":"EntryName","value":"PyrdxlP-dep_de-COase"}]},{"database":"InterPro","id":"IPR015424","properties":[{"key":"EntryName","value":"PyrdxlP-dep_Trfase"}]},{"database":"InterPro","id":"IPR015421","properties":[{"key":"EntryName","value":"PyrdxlP-dep_Trfase_major"}]},{"database":"InterPro","id":"IPR021115","properties":[{"key":"EntryName","value":"Pyridoxal-P_BS"}]},{"database":"PANTHER","id":"PTHR45677:SF11","properties":[{"key":"EntryName","value":"GLUTAMATE DECARBOXYLASE 2"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR45677","properties":[{"key":"EntryName","value":"GLUTAMATE DECARBOXYLASE-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00282","properties":[{"key":"EntryName","value":"Pyridoxal_deC"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF53383","properties":[{"key":"EntryName","value":"PLP-dependent transferases"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00392","properties":[{"key":"EntryName","value":"DDC_GAD_HDC_YDC"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MASPGSGFWSFGSEDGSGDSENPGTARAWCQVAQKFTGGIGNKLCALLYGDAEKPAESGGSQPPRAAARKAACACDQKPCSCSKVDVNYAFLHATDLLPACDGERPTLAFLQDVMNILLQYVVKSFDRSTKVIDFHYPNELLQEYNWELADQPQNLEEILMHCQTTLKYAIKTGHPRYFNQLSTGLDMVGLAADWLTSTANTNMFTYEIAPVFVLLEYVTLKKMREIIGWPGGSGDGIFSPGGAISNMYAMMIARFKMFPEVKEKGMAALPRLIAFTSEHSHFSLKKGAAALGIGTDSVILIKCDERGKMIPSDLERRILEAKQKGFVPFLVSATAGTTVYGAFDPLLAVADICKKYKIWMHVDAAWGGGLLMSRKHKWKLSGVERANSVTWNPHKMMGVPLQCSALLVREEGLMQNCNQMHASYLFQQDKHYDLSYDTGDKALQCGRHVDVFKLWLMWRAKGTTGFEAHVDKCLELAEYLYNIIKNREGYEMVFDGKPQHTNVCFWYIPPSLRTLEDNEERMSRLSKVAPVIKARMMEYGTTMVSYQPLGDKVNFFRMVISNPAATHQDIDFLIEEIERLGQDL","length":585,"molWeight":65411,"crc64":"0322509F0E2C32EE","md5":"D5882A67D7D207BF295172378FBAC572"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"COFACTOR":1,"BIOPHYSICOCHEMICAL PROPERTIES":1,"SUBUNIT":1,"INTERACTION":42,"SUBCELLULAR LOCATION":1,"PTM":2,"SIMILARITY":1,"SEQUENCE CAUTION":1},"countByFeatureType":{"Chain":1,"Region":1,"Compositional bias":1,"Binding site":2,"Modified residue":5,"Lipidation":2,"Natural variant":7,"Mutagenesis":1,"Helix":26,"Beta strand":13,"Turn":4},"uniParcId":"UPI0000033835"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A3B3IU09","uniProtkbId":"A0A3B3IU09_HUMAN","entryAudit":{"firstPublicDate":"2018-12-05","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2018-12-05","entryVersion":38,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000498009.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00040577"}],"value":"Glutamate decarboxylase 2"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012421"}],"value":"4.1.1.15"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00043203"}],"value":"65 kDa glutamic acid decarboxylase"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00041381"}],"value":"Glutamate decarboxylase 65 kDa isoform"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000498009.1"}],"value":"GAD2"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00037048"}],"value":"Catalyzes the production of GABA"}],"commentType":"FUNCTION"},{"commentType":"COFACTOR","cofactors":[{"name":"pyridoxal 5'-phosphate","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001933"},{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR602129-50"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000382"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:597326"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00011738"}],"value":"Homodimer"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004514"}],"value":"Cytoplasm, cytosol","id":"SL-0091"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004541"}],"value":"Cytoplasmic vesicle","id":"SL-0088"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004255"}],"value":"Golgi apparatus membrane","id":"SL-0134"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004255"}],"value":"Peripheral membrane protein","id":"SL-9903"},"orientation":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004255"}],"value":"Cytoplasmic side","id":"SL-9910"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00037840"}],"value":"Presynaptic cell membrane","id":"SL-0222"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00037840"}],"value":"Lipid-anchor","id":"SL-9901"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009533"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000382"}],"value":"Belongs to the group II decarboxylase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":394,"modifier":"EXACT"}},"description":"Pyridoxal phosphate-dependent decarboxylase major","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00282"}]},{"type":"Modified residue","location":{"start":{"value":282,"modifier":"EXACT"},"end":{"value":282,"modifier":"EXACT"}},"description":"N6-(pyridoxal phosphate)lysine","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR602129-50"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023273"}],"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023329"}],"id":"KW-0968","category":"Cellular component","name":"Cytoplasmic vesicle"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022793"}],"id":"KW-0210","category":"Molecular function","name":"Decarboxylase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023034"}],"id":"KW-0333","category":"Cellular component","name":"Golgi apparatus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023288"}],"id":"KW-0449","category":"PTM","name":"Lipoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023239"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000382"}],"id":"KW-0456","category":"Molecular function","name":"Lyase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022979"}],"id":"KW-0530","category":"Biological process","name":"Neurotransmitter biosynthesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023139"}],"id":"KW-0564","category":"PTM","name":"Palmitate"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0A3B3IU09"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0A3B3IU09"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022898"},{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR602129-50"}],"id":"KW-0663","category":"Ligand","name":"Pyridoxal phosphate"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023018"}],"id":"KW-0770","category":"Cellular component","name":"Synapse"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000498009.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15164054","citationType":"journal article","authors":["Deloukas P.","Earthrowl M.E.","Grafham D.V.","Rubenfield M.","French L.","Steward C.A.","Sims S.K.","Jones M.C.","Searle S.","Scott C.","Howe K.","Hunt S.E.","Andrews T.D.","Gilbert J.G.","Swarbreck D.","Ashurst J.L.","Taylor A.","Battles J.","Bird C.P.","Ainscough R.","Almeida J.P.","Ashwell R.I.","Ambrose K.D.","Babbage A.K.","Bagguley C.L.","Bailey J.","Banerjee R.","Bates K.","Beasley H.","Bray-Allen S.","Brown A.J.","Brown J.Y.","Burford D.C.","Burrill W.","Burton J.","Cahill P.","Camire D.","Carter N.P.","Chapman J.C.","Clark S.Y.","Clarke G.","Clee C.M.","Clegg S.","Corby N.","Coulson A.","Dhami P.","Dutta I.","Dunn M.","Faulkner L.","Frankish A.","Frankland J.A.","Garner P.","Garnett J.","Gribble S.","Griffiths C.","Grocock R.","Gustafson E.","Hammond S.","Harley J.L.","Hart E.","Heath P.D.","Ho T.P.","Hopkins B.","Horne J.","Howden P.J.","Huckle E.","Hynds C.","Johnson C.","Johnson D.","Kana A.","Kay M.","Kimberley A.M.","Kershaw J.K.","Kokkinaki M.","Laird G.K.","Lawlor S.","Lee H.M.","Leongamornlert D.A.","Laird G.","Lloyd C.","Lloyd D.M.","Loveland J.","Lovell J.","McLaren S.","McLay K.E.","McMurray A.","Mashreghi-Mohammadi M.","Matthews L.","Milne S.","Nickerson T.","Nguyen M.","Overton-Larty E.","Palmer S.A.","Pearce A.V.","Peck A.I.","Pelan S.","Phillimore B.","Porter K.","Rice C.M.","Rogosin A.","Ross M.T.","Sarafidou T.","Sehra H.K.","Shownkeen R.","Skuce C.D.","Smith M.","Standring L.","Sycamore N.","Tester J.","Thorpe A.","Torcasso W.","Tracey A.","Tromans A.","Tsolas J.","Wall M.","Walsh J.","Wang H.","Weinstock K.","West A.P.","Willey D.L.","Whitehead S.L.","Wilming L.","Wray P.W.","Young L.","Chen Y.","Lovering R.C.","Moschonas N.K.","Siebert R.","Fechtel K.","Bentley D.","Durbin R.","Hubbard T.","Doucette-Stamm L.","Beck S.","Smith D.R.","Rogers J."],"citationCrossReferences":[{"database":"PubMed","id":"15164054"},{"database":"DOI","id":"10.1038/nature02462"}],"title":"The DNA sequence and comparative analysis of human chromosome 10.","publicationDate":"2004","journal":"Nature","firstPage":"375","lastPage":"381","volume":"429"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000498009.1"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000498009.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000498009.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL162503","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A3B3IU09","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0A3B3IU09","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"A0A3B3IU09","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"3635","properties":[{"key":"antibodies","value":"789 antibodies from 46 providers"}]},{"database":"Ensembl","id":"ENST00000648567.1","properties":[{"key":"ProteinId","value":"ENSP00000498009.1"},{"key":"GeneId","value":"ENSG00000136750.13"}]},{"database":"HGNC","id":"HGNC:4093","properties":[{"key":"GeneName","value":"GAD2"}]},{"database":"OpenTargets","id":"ENSG00000136750","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000136750","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000157951","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"392571at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"GAD2","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 10"}]},{"database":"Bgee","id":"ENSG00000136750","properties":[{"key":"ExpressionPatterns","value":"Expressed in islet of Langerhans and 90 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"A0A3B3IU09","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0031410","properties":[{"key":"GoTerm","value":"C:cytoplasmic vesicle"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0000139","properties":[{"key":"GoTerm","value":"C:Golgi membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0042734","properties":[{"key":"GoTerm","value":"C:presynaptic membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0004351","properties":[{"key":"GoTerm","value":"F:glutamate decarboxylase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0030170","properties":[{"key":"GoTerm","value":"F:pyridoxal phosphate binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd06450","properties":[{"key":"EntryName","value":"DOPA_deC_like"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.640.10:FF:000016","properties":[{"key":"EntryName","value":"Glutamate decarboxylase like 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.90.1150.170","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.640.10","properties":[{"key":"EntryName","value":"Type I PLP-dependent aspartate aminotransferase-like (Major domain)"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR002129","properties":[{"key":"EntryName","value":"PyrdxlP-dep_de-COase"}]},{"database":"InterPro","id":"IPR015424","properties":[{"key":"EntryName","value":"PyrdxlP-dep_Trfase"}]},{"database":"InterPro","id":"IPR015421","properties":[{"key":"EntryName","value":"PyrdxlP-dep_Trfase_major"}]},{"database":"InterPro","id":"IPR021115","properties":[{"key":"EntryName","value":"Pyridoxal-P_BS"}]},{"database":"PANTHER","id":"PTHR45677:SF11","properties":[{"key":"EntryName","value":"GLUTAMATE DECARBOXYLASE 2"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR45677","properties":[{"key":"EntryName","value":"GLUTAMATE DECARBOXYLASE-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00282","properties":[{"key":"EntryName","value":"Pyridoxal_deC"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF53383","properties":[{"key":"EntryName","value":"PLP-dependent transferases"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00392","properties":[{"key":"EntryName","value":"DDC_GAD_HDC_YDC"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MNILLQYVVKSFDRSTKVIDFHYPNELLQEYNWELADQPQNLEEILMHCQTTLKYAIKTGHPRYFNQLSTGLDMVGLAADWLTSTANTNMFTYEIAPVFVLLEYVTLKKMREIIGWPGGSGDGIFSPGGAISNMYAMMIARFKMFPEVKEKGMAALPRLIAFTSEHSHFSLKKGAAALGIGTDSVILIKCDERGKMIPSDLERRILEAKQKGFVPFLVSATAGTTVYGAFDPLLAVADICKKYKIWMHVDAAWGGGLLMSRKHKWKLSGVERANSVTWNPHKMMGVPLQCSALLVREEGLMQNCNQMHASYLFQQDKHYDLSYDTGDKALQCGRHVDVFKLWLMWRAKGTTGFEAHVDKCLELAEYLYNIIKNREGYEMVFDGKPQHTNVCFWYIPPSLRTLEDNEERMSRLSKVAPVIKARMMEYGTTMVSYQPLGDKVNFFRMVISNPAATHQDIDFLIEEIERLGQDL","length":471,"molWeight":53626,"crc64":"A03EAC84ADC36C2C","md5":"BC685962583CB90383885330A12A782D"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"COFACTOR":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Domain":1,"Modified residue":1},"uniParcId":"UPI000E6EE212"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q5VZ30","uniProtkbId":"Q5VZ30_HUMAN","entryAudit":{"firstPublicDate":"2005-05-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2005-05-10","entryVersion":165,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAI26330.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00040577"}],"value":"Glutamate decarboxylase 2"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012421"}],"value":"4.1.1.15"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00043203"}],"value":"65 kDa glutamic acid decarboxylase"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00041381"}],"value":"Glutamate decarboxylase 65 kDa isoform"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAI26330.1"}],"value":"GAD2"},"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"EAW86102.1"}],"value":"hCG_23434"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00037048"}],"value":"Catalyzes the production of GABA"}],"commentType":"FUNCTION"},{"commentType":"COFACTOR","cofactors":[{"name":"pyridoxal 5'-phosphate","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001933"},{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR602129-50"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000382"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:597326"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00011738"}],"value":"Homodimer"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004514"}],"value":"Cytoplasm, cytosol","id":"SL-0091"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004541"}],"value":"Cytoplasmic vesicle","id":"SL-0088"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004255"}],"value":"Golgi apparatus membrane","id":"SL-0134"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004255"}],"value":"Peripheral membrane protein","id":"SL-9903"},"orientation":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004255"}],"value":"Cytoplasmic side","id":"SL-9910"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00037840"}],"value":"Presynaptic cell membrane","id":"SL-0222"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00037840"}],"value":"Lipid-anchor","id":"SL-9901"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009533"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000382"}],"value":"Belongs to the group II decarboxylase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":138,"modifier":"EXACT"},"end":{"value":508,"modifier":"EXACT"}},"description":"Pyridoxal phosphate-dependent decarboxylase major","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00282"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":24,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":14,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":396,"modifier":"EXACT"},"end":{"value":396,"modifier":"EXACT"}},"description":"N6-(pyridoxal phosphate)lysine","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR602129-50"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023273"}],"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023329"}],"id":"KW-0968","category":"Cellular component","name":"Cytoplasmic vesicle"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022793"}],"id":"KW-0210","category":"Molecular function","name":"Decarboxylase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023034"}],"id":"KW-0333","category":"Cellular component","name":"Golgi apparatus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023288"}],"id":"KW-0449","category":"PTM","name":"Lipoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023239"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000382"}],"id":"KW-0456","category":"Molecular function","name":"Lyase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022979"}],"id":"KW-0530","category":"Biological process","name":"Neurotransmitter biosynthesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023139"}],"id":"KW-0564","category":"PTM","name":"Palmitate"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022898"},{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR602129-50"}],"id":"KW-0663","category":"Ligand","name":"Pyridoxal phosphate"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023018"}],"id":"KW-0770","category":"Cellular component","name":"Synapse"}],"references":[{"referenceNumber":1,"citation":{"id":"11181995","citationType":"journal article","authors":["Venter J.C.","Adams M.D.","Myers E.W.","Li P.W.","Mural R.J.","Sutton G.G.","Smith H.O.","Yandell M.","Evans C.A.","Holt R.A.","Gocayne J.D.","Amanatides P.","Ballew R.M.","Huson D.H.","Wortman J.R.","Zhang Q.","Kodira C.D.","Zheng X.H.","Chen L.","Skupski M.","Subramanian G.","Thomas P.D.","Zhang J.","Gabor Miklos G.L.","Nelson C.","Broder S.","Clark A.G.","Nadeau J.","McKusick V.A.","Zinder N.","Levine A.J.","Roberts R.J.","Simon M.","Slayman C.","Hunkapiller M.","Bolanos R.","Delcher A.","Dew I.","Fasulo D.","Flanigan M.","Florea L.","Halpern A.","Hannenhalli S.","Kravitz S.","Levy S.","Mobarry C.","Reinert K.","Remington K.","Abu-Threideh J.","Beasley E.","Biddick K.","Bonazzi V.","Brandon R.","Cargill M.","Chandramouliswaran I.","Charlab R.","Chaturvedi K.","Deng Z.","Di Francesco V.","Dunn P.","Eilbeck K.","Evangelista C.","Gabrielian A.E.","Gan W.","Ge W.","Gong F.","Gu Z.","Guan P.","Heiman T.J.","Higgins M.E.","Ji R.R.","Ke Z.","Ketchum K.A.","Lai Z.","Lei Y.","Li Z.","Li J.","Liang Y.","Lin X.","Lu F.","Merkulov G.V.","Milshina N.","Moore H.M.","Naik A.K.","Narayan V.A.","Neelam B.","Nusskern D.","Rusch D.B.","Salzberg S.","Shao W.","Shue B.","Sun J.","Wang Z.","Wang A.","Wang X.","Wang J.","Wei M.","Wides R.","Xiao C.","Yan C.","Yao A.","Ye J.","Zhan M.","Zhang W.","Zhang H.","Zhao Q.","Zheng L.","Zhong F.","Zhong W.","Zhu S.","Zhao S.","Gilbert D.","Baumhueter S.","Spier G.","Carter C.","Cravchik A.","Woodage T.","Ali F.","An H.","Awe A.","Baldwin D.","Baden H.","Barnstead M.","Barrow I.","Beeson K.","Busam D.","Carver A.","Center A.","Cheng M.L.","Curry L.","Danaher S.","Davenport L.","Desilets R.","Dietz S.","Dodson K.","Doup L.","Ferriera S.","Garg N.","Gluecksmann A.","Hart B.","Haynes J.","Haynes C.","Heiner C.","Hladun S.","Hostin D.","Houck J.","Howland T.","Ibegwam C.","Johnson J.","Kalush F.","Kline L.","Koduru S.","Love A.","Mann F.","May D.","McCawley S.","McIntosh T.","McMullen I.","Moy M.","Moy L.","Murphy B.","Nelson K.","Pfannkoch C.","Pratts E.","Puri V.","Qureshi H.","Reardon M.","Rodriguez R.","Rogers Y.H.","Romblad D.","Ruhfel B.","Scott R.","Sitter C.","Smallwood M.","Stewart E.","Strong R.","Suh E.","Thomas R.","Tint N.N.","Tse S.","Vech C.","Wang G.","Wetter J.","Williams S.","Williams M.","Windsor S.","Winn-Deen E.","Wolfe K.","Zaveri J.","Zaveri K.","Abril J.F.","Guigo R.","Campbell M.J.","Sjolander K.V.","Karlak B.","Kejariwal A.","Mi H.","Lazareva B.","Hatton T.","Narechania A.","Diemer K.","Muruganujan A.","Guo N.","Sato S.","Bafna V.","Istrail S.","Lippert R.","Schwartz R.","Walenz B.","Yooseph S.","Allen D.","Basu A.","Baxendale J.","Blick L.","Caminha M.","Carnes-Stine J.","Caulk P.","Chiang Y.H.","Coyne M.","Dahlke C.","Mays A.","Dombroski M.","Donnelly M.","Ely D.","Esparham S.","Fosler C.","Gire H.","Glanowski S.","Glasser K.","Glodek A.","Gorokhov M.","Graham K.","Gropman B.","Harris M.","Heil J.","Henderson S.","Hoover J.","Jennings D.","Jordan C.","Jordan J.","Kasha J.","Kagan L.","Kraft C.","Levitsky A.","Lewis M.","Liu X.","Lopez J.","Ma D.","Majoros W.","McDaniel J.","Murphy S.","Newman M.","Nguyen T.","Nguyen N.","Nodell M.","Pan S.","Peck J.","Peterson M.","Rowe W.","Sanders R.","Scott J.","Simpson M.","Smith T.","Sprague A.","Stockwell T.","Turner R.","Venter E.","Wang M.","Wen M.","Wu D.","Wu M.","Xia A.","Zandieh A.","Zhu X."],"citationCrossReferences":[{"database":"PubMed","id":"11181995"},{"database":"DOI","id":"10.1126/science.1058040"}],"title":"The sequence of the human genome.","publicationDate":"2001","journal":"Science","firstPage":"1304","lastPage":"1351","volume":"291"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"EAW86102.1"}]},{"referenceNumber":2,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"authors":["Gerhard D.S.","Wagner L.","Feingold E.A.","Shenmen C.M.","Grouse L.H.","Schuler G.","Klein S.L.","Old S.","Rasooly R.","Good P.","Guyer M.","Peck A.M.","Derge J.G.","Lipman D.","Collins F.S.","Jang W.","Sherry S.","Feolo M.","Misquitta L.","Lee E.","Rotmistrovsky K.","Greenhut S.F.","Schaefer C.F.","Buetow K.","Bonner T.I.","Haussler D.","Kent J.","Kiekhaus M.","Furey T.","Brent M.","Prange C.","Schreiber K.","Shapiro N.","Bhat N.K.","Hopkins R.F.","Hsie F.","Driscoll T.","Soares M.B.","Casavant T.L.","Scheetz T.E.","Brown-stein M.J.","Usdin T.B.","Toshiyuki S.","Carninci P.","Piao Y.","Dudekula D.B.","Ko M.S.","Kawakami K.","Suzuki Y.","Sugano S.","Gruber C.E.","Smith M.R.","Simmons B.","Moore T.","Waterman R.","Johnson S.L.","Ruan Y.","Wei C.L.","Mathavan S.","Gunaratne P.H.","Wu J.","Garcia A.M.","Hulyk S.W.","Fuh E.","Yuan Y.","Sneed A.","Kowis C.","Hodgson A.","Muzny D.M.","McPherson J.","Gibbs R.A.","Fahey J.","Helton E.","Ketteman M.","Madan A.","Rodrigues S.","Sanchez A.","Whiting M.","Madari A.","Young A.C.","Wetherby K.D.","Granite S.J.","Kwong P.N.","Brinkley C.P.","Pearson R.L.","Bouffard G.G.","Blakesly R.W.","Green E.D.","Dickson M.C.","Rodriguez A.C.","Grimwood J.","Schmutz J.","Myers R.M.","Butterfield Y.S.","Griffith M.","Griffith O.L.","Krzywinski M.I.","Liao N.","Morin R.","Morrin R.","Palmquist D.","Petrescu A.S.","Skalska U.","Smailus D.E.","Stott J.M.","Schnerch A.","Schein J.E.","Jones S.J.","Holt R.A.","Baross A.","Marra M.A.","Clifton S.","Makowski K.A.","Bosak S.","Malek J."],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAI26330.1"}],"value":"Brain","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAI26330.1"}]},{"referenceNumber":3,"citation":{"id":"CI-56FTJV1JKRRTT","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"SEP-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"EAW86102.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"BC126327","properties":[{"key":"ProteinId","value":"AAI26328.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC126329","properties":[{"key":"ProteinId","value":"AAI26330.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"CH471072","properties":[{"key":"ProteinId","value":"EAW86102.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"NP_000809.1","properties":[{"key":"NucleotideSequenceId","value":"NM_000818.3"}]},{"database":"RefSeq","id":"NP_001127838.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001134366.2"}]},{"database":"AlphaFoldDB","id":"Q5VZ30","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q5VZ30","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"Q5VZ30","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"3635","properties":[{"key":"antibodies","value":"789 antibodies from 46 providers"}]},{"database":"DNASU","id":"2572","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"2572","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:2572","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc001isp.3","properties":[{"key":"OrganismName","value":"human"}]},{"database":"ClinPGx","id":"PA28508","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"2572","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"2572","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000136750","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_011856_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"AGMVIFK","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"392571at2759","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"2572","properties":[{"key":"hits","value":"12 hits in 1152 CRISPR screens"}]},{"database":"ChiTaRS","id":"GAD2","properties":[{"key":"OrganismName","value":"human"}]},{"database":"ExpressionAtlas","id":"Q5VZ30","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0030424","properties":[{"key":"GoTerm","value":"C:axon"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0031410","properties":[{"key":"GoTerm","value":"C:cytoplasmic vesicle"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0000139","properties":[{"key":"GoTerm","value":"C:Golgi membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0042734","properties":[{"key":"GoTerm","value":"C:presynaptic membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0004351","properties":[{"key":"GoTerm","value":"F:glutamate decarboxylase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0030170","properties":[{"key":"GoTerm","value":"F:pyridoxal phosphate binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd06450","properties":[{"key":"EntryName","value":"DOPA_deC_like"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.640.10:FF:000016","properties":[{"key":"EntryName","value":"Glutamate decarboxylase like 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.90.1150.170","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.640.10","properties":[{"key":"EntryName","value":"Type I PLP-dependent aspartate aminotransferase-like (Major domain)"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR002129","properties":[{"key":"EntryName","value":"PyrdxlP-dep_de-COase"}]},{"database":"InterPro","id":"IPR015424","properties":[{"key":"EntryName","value":"PyrdxlP-dep_Trfase"}]},{"database":"InterPro","id":"IPR015421","properties":[{"key":"EntryName","value":"PyrdxlP-dep_Trfase_major"}]},{"database":"InterPro","id":"IPR021115","properties":[{"key":"EntryName","value":"Pyridoxal-P_BS"}]},{"database":"PANTHER","id":"PTHR45677:SF11","properties":[{"key":"EntryName","value":"GLUTAMATE DECARBOXYLASE 2"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR45677","properties":[{"key":"EntryName","value":"GLUTAMATE DECARBOXYLASE-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00282","properties":[{"key":"EntryName","value":"Pyridoxal_deC"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF53383","properties":[{"key":"EntryName","value":"PLP-dependent transferases"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00392","properties":[{"key":"EntryName","value":"DDC_GAD_HDC_YDC"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MASPGSGFWSFGSEDGSGDSENPGTARAWCQVAQKFTGGIGNKLCALLYGDAEKPAESGGSQPPRAAARKAACACDQKPCSCSKVDVNYAFLHATDLLPACDGERPTLAFLQDVMNILLQYVVKSFDRSTKVIDFHYPNELLQEYNWELADQPQNLEEILMHCQTTLKYAIKTGHPRYFNQLSTGLDMVGLAADWLTSTANTNMFTYEIAPVFVLLEYVTLKKMREIIGWPGGSGDGIFSPGGAISNMYAMMIARFKMFPEVKEKGMAALPRLIAFTSEHSHFSLKKGAAALGIGTDSVILIKCDERGKMIPSDLERRILEAKQKGFVPFLVSATAGTTVYGAFDPLLAVADICKKYKIWMHVDAAWGGGLLMSRKHKWKLSGVERANSVTWNPHKMMGVPLQCSALLVREEGLMQNCNQMHASYLFQQDKHYDLSYDTGDKALQCGRHVDVFKLWLMWRAKGTTGFEAHVDKCLELAEYLYNIIKNREGYEMVFDGKPQHTNVCFWYIPPSLRTLEDNEERMSRLSKVAPVIKARMMEYGTTMVSYQPLGDKVNFFRMVISNPAATHQDIDFLIEEIERLGQDL","length":585,"molWeight":65411,"crc64":"0322509F0E2C32EE","md5":"D5882A67D7D207BF295172378FBAC572"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"COFACTOR":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Domain":1,"Region":1,"Compositional bias":1,"Modified residue":1},"uniParcId":"UPI0000033835"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q4G154","uniProtkbId":"Q4G154_HUMAN","entryAudit":{"firstPublicDate":"2005-08-30","lastAnnotationUpdateDate":"2026-06-10","lastSequenceUpdateDate":"2005-08-30","entryVersion":74,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAH29517.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012421"}],"value":"glutamate decarboxylase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012421"}],"value":"4.1.1.15"}]},"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAH29517.1"}],"value":"GAD2"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00011738"}],"value":"Homodimer"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009533"}],"value":"Belongs to the group II decarboxylase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":24,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":14,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":192,"modifier":"EXACT"},"end":{"value":192,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAH29517.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022793"}],"id":"KW-0210","category":"Molecular function","name":"Decarboxylase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022793"}],"id":"KW-0456","category":"Molecular function","name":"Lyase"}],"references":[{"referenceNumber":1,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"authors":["Gerhard D.S.","Wagner L.","Feingold E.A.","Shenmen C.M.","Grouse L.H.","Schuler G.","Klein S.L.","Old S.","Rasooly R.","Good P.","Guyer M.","Peck A.M.","Derge J.G.","Lipman D.","Collins F.S.","Jang W.","Sherry S.","Feolo M.","Misquitta L.","Lee E.","Rotmistrovsky K.","Greenhut S.F.","Schaefer C.F.","Buetow K.","Bonner T.I.","Haussler D.","Kent J.","Kiekhaus M.","Furey T.","Brent M.","Prange C.","Schreiber K.","Shapiro N.","Bhat N.K.","Hopkins R.F.","Hsie F.","Driscoll T.","Soares M.B.","Casavant T.L.","Scheetz T.E.","Brown-stein M.J.","Usdin T.B.","Toshiyuki S.","Carninci P.","Piao Y.","Dudekula D.B.","Ko M.S.","Kawakami K.","Suzuki Y.","Sugano S.","Gruber C.E.","Smith M.R.","Simmons B.","Moore T.","Waterman R.","Johnson S.L.","Ruan Y.","Wei C.L.","Mathavan S.","Gunaratne P.H.","Wu J.","Garcia A.M.","Hulyk S.W.","Fuh E.","Yuan Y.","Sneed A.","Kowis C.","Hodgson A.","Muzny D.M.","McPherson J.","Gibbs R.A.","Fahey J.","Helton E.","Ketteman M.","Madan A.","Rodrigues S.","Sanchez A.","Whiting M.","Madari A.","Young A.C.","Wetherby K.D.","Granite S.J.","Kwong P.N.","Brinkley C.P.","Pearson R.L.","Bouffard G.G.","Blakesly R.W.","Green E.D.","Dickson M.C.","Rodriguez A.C.","Grimwood J.","Schmutz J.","Myers R.M.","Butterfield Y.S.","Griffith M.","Griffith O.L.","Krzywinski M.I.","Liao N.","Morin R.","Morrin R.","Palmquist D.","Petrescu A.S.","Skalska U.","Smailus D.E.","Stott J.M.","Schnerch A.","Schein J.E.","Jones S.J.","Holt R.A.","Baross A.","Marra M.A.","Clifton S.","Makowski K.A.","Bosak S.","Malek J."],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAH29517.1"}],"value":"Brain","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAH29517.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"BC029517","properties":[{"key":"ProteinId","value":"AAH29517.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"Q4G154","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q4G154","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q4G154","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"392571at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"GAD2","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GO","id":"GO:0004351","properties":[{"key":"GoTerm","value":"F:glutamate decarboxylase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"Gene3D","id":"3.90.1150.170","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR45677:SF11","properties":[{"key":"EntryName","value":"GLUTAMATE DECARBOXYLASE 2"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR45677","properties":[{"key":"EntryName","value":"GLUTAMATE DECARBOXYLASE-RELATED"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MASPGSGFWSFGSEDGSGDSENPGTARAWCQVAQKFTGGIGNKLCALLYGDAEKPAESGGSQPPRAAARKAACACDQKPCSCSKVDVNYAFLHATDLLPACDGERPTLAFLQDVMNILLQYVVKSFDRSTKVIDFHYPNELLQEYNWELADQPQNLEEILMHCQTTLKYAIKTGIVSSKIIKLFFRLQKKKK","length":192,"molWeight":21147,"crc64":"1B954E8319CEBEE1","md5":"445DC56E732C768FEB51BF3D78DB6301"},"extraAttributes":{"countByCommentType":{"SUBUNIT":1,"SIMILARITY":1},"countByFeatureType":{"Region":1,"Compositional bias":1,"Non-terminal residue":1},"uniParcId":"UPI000056D3F2"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q5VZ31","uniProtkbId":"Q5VZ31_HUMAN","entryAudit":{"firstPublicDate":"2004-12-07","lastAnnotationUpdateDate":"2026-06-10","lastSequenceUpdateDate":"2004-12-07","entryVersion":114,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000390434.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012421"}],"value":"glutamate decarboxylase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012421"}],"value":"4.1.1.15"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000390434.2"}],"value":"GAD2"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00011738"}],"value":"Homodimer"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009533"}],"value":"Belongs to the group II decarboxylase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":24,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":14,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022793"}],"id":"KW-0210","category":"Molecular function","name":"Decarboxylase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022793"}],"id":"KW-0456","category":"Molecular function","name":"Lyase"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"Q5VZ31"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"Q5VZ31"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000390434.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15164054","citationType":"journal article","authors":["Deloukas P.","Earthrowl M.E.","Grafham D.V.","Rubenfield M.","French L.","Steward C.A.","Sims S.K.","Jones M.C.","Searle S.","Scott C.","Howe K.","Hunt S.E.","Andrews T.D.","Gilbert J.G.","Swarbreck D.","Ashurst J.L.","Taylor A.","Battles J.","Bird C.P.","Ainscough R.","Almeida J.P.","Ashwell R.I.","Ambrose K.D.","Babbage A.K.","Bagguley C.L.","Bailey J.","Banerjee R.","Bates K.","Beasley H.","Bray-Allen S.","Brown A.J.","Brown J.Y.","Burford D.C.","Burrill W.","Burton J.","Cahill P.","Camire D.","Carter N.P.","Chapman J.C.","Clark S.Y.","Clarke G.","Clee C.M.","Clegg S.","Corby N.","Coulson A.","Dhami P.","Dutta I.","Dunn M.","Faulkner L.","Frankish A.","Frankland J.A.","Garner P.","Garnett J.","Gribble S.","Griffiths C.","Grocock R.","Gustafson E.","Hammond S.","Harley J.L.","Hart E.","Heath P.D.","Ho T.P.","Hopkins B.","Horne J.","Howden P.J.","Huckle E.","Hynds C.","Johnson C.","Johnson D.","Kana A.","Kay M.","Kimberley A.M.","Kershaw J.K.","Kokkinaki M.","Laird G.K.","Lawlor S.","Lee H.M.","Leongamornlert D.A.","Laird G.","Lloyd C.","Lloyd D.M.","Loveland J.","Lovell J.","McLaren S.","McLay K.E.","McMurray A.","Mashreghi-Mohammadi M.","Matthews L.","Milne S.","Nickerson T.","Nguyen M.","Overton-Larty E.","Palmer S.A.","Pearce A.V.","Peck A.I.","Pelan S.","Phillimore B.","Porter K.","Rice C.M.","Rogosin A.","Ross M.T.","Sarafidou T.","Sehra H.K.","Shownkeen R.","Skuce C.D.","Smith M.","Standring L.","Sycamore N.","Tester J.","Thorpe A.","Torcasso W.","Tracey A.","Tromans A.","Tsolas J.","Wall M.","Walsh J.","Wang H.","Weinstock K.","West A.P.","Willey D.L.","Whitehead S.L.","Wilming L.","Wray P.W.","Young L.","Chen Y.","Lovering R.C.","Moschonas N.K.","Siebert R.","Fechtel K.","Bentley D.","Durbin R.","Hubbard T.","Doucette-Stamm L.","Beck S.","Smith D.R.","Rogers J."],"citationCrossReferences":[{"database":"PubMed","id":"15164054"},{"database":"DOI","id":"10.1038/nature02462"}],"title":"The DNA sequence and comparative analysis of human chromosome 10.","publicationDate":"2004","journal":"Nature","firstPage":"375","lastPage":"381","volume":"429"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000390434.2"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000390434.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000390434.2"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL162503","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"Q5VZ31","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q5VZ31","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q5VZ31","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"65667","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000428517.2","properties":[{"key":"ProteinId","value":"ENSP00000390434.2"},{"key":"GeneId","value":"ENSG00000136750.13"}]},{"database":"UCSC","id":"uc009xkr.5","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:4093","properties":[{"key":"GeneName","value":"GAD2"}]},{"database":"OpenTargets","id":"ENSG00000136750","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000136750","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000157951","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_1444094_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"392571at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"GAD2","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 10"}]},{"database":"Bgee","id":"ENSG00000136750","properties":[{"key":"ExpressionPatterns","value":"Expressed in islet of Langerhans and 90 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q5VZ31","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0004351","properties":[{"key":"GoTerm","value":"F:glutamate decarboxylase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"Gene3D","id":"3.90.1150.170","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR45677:SF11","properties":[{"key":"EntryName","value":"GLUTAMATE DECARBOXYLASE 2"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR45677","properties":[{"key":"EntryName","value":"GLUTAMATE DECARBOXYLASE-RELATED"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MASPGSGFWSFGSEDGSGDSENPGTARAWCQVAQKFTGGIGNKLCALLYGDAEKPAESGGSQPPRAAARKAACACDQKPCSCSKVDVNYAFLHATDLLPACDGERPTLAFLQDVMNILLQYVVKSFDRSTKVIDFHYPNELLQEYNWELADQPQNLEEILMHCQTTLKYAIKTGIVSSKIIKLFFRLQ","length":188,"molWeight":20634,"crc64":"39CEBEE15BB21455","md5":"F877C9DFDD8465796842B84261DADCB9"},"extraAttributes":{"countByCommentType":{"SUBUNIT":1,"SIMILARITY":1},"countByFeatureType":{"Region":1,"Compositional bias":1},"uniParcId":"UPI00004588DC"}}]}