{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q14802","secondaryAccessions":["A6NDE0","C9JDU2","F5H174","F8WB34","Q13211","Q6IB59"],"uniProtkbId":"FXYD3_HUMAN","entryAudit":{"firstPublicDate":"1998-07-15","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1996-11-01","entryVersion":202,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"FXYD domain-containing ion transport regulator 3"}},"alternativeNames":[{"fullName":{"value":"Chloride conductance inducer protein Mat-8"}},{"fullName":{"value":"Mammary tumor 8 kDa protein"}},{"fullName":{"value":"Phospholemman-like"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Sodium/potassium-transporting ATPase subunit FXYD3"}}],"flag":"Precursor"},"genes":[{"geneName":{"value":"FXYD3"},"synonyms":[{"value":"MAT8"},{"value":"PLML"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17077088"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21454534"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7836447"}],"value":"Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell (PubMed:17077088). Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1 (PubMed:21454534). Induces a hyperpolarization-activated chloride current when expressed in Xenopus oocytes (PubMed:7836447)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17077088"}],"value":"Decreases the apparent K+ and Na+ affinity of the sodium/potassium-transporting ATPase over a large range of membrane potentials"}],"commentType":"FUNCTION","molecule":"Isoform 1"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17077088"}],"value":"Decreases the apparent K+ affinity of the sodium/potassium-transporting ATPase only at slightly negative and positive membrane potentials and increases the apparent Na+ affinity over a large range of membrane potentials"}],"commentType":"FUNCTION","molecule":"Isoform 2"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q61835"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17077088"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21454534"}],"value":"Regulatory subunit of the sodium/potassium-transporting ATPase which is composed of a catalytic alpha subunit, a non-catalytic beta subunit and an additional regulatory subunit (PubMed:17077088). Interacts with catalytic alpha subunit ATP1A1 (PubMed:21454534). Also interacts with non-catalytic beta subunit ATP1B1 (By similarity). Interacts with the ATP1A1-ATP1B1, ATP1A2-ATP1B1 and ATP1A3-ATP1B1 NKA isozymes 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