{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q10981","secondaryAccessions":["Q0VAG5","Q14338","Q5D0G2"],"uniProtkbId":"FUT2_HUMAN","entryAudit":{"firstPublicDate":"1996-10-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1996-10-01","entryVersion":208,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Galactoside alpha-(1,2)-fucosyltransferase 2"}},"alternativeNames":[{"fullName":{"value":"Alpha(1,2)FT 2"}},{"fullName":{"value":"Fucosyltransferase 2"}},{"fullName":{"value":"GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2"}},{"fullName":{"value":"SE2"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"7876235"}],"value":"Secretor blood group alpha-2-fucosyltransferase"}},{"fullName":{"value":"Secretor factor"},"shortNames":[{"value":"Se"}]},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Type 1 galactoside alpha-(1,2)-fucosyltransferase FUT2"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7876235"}],"value":"2.4.1.69"}]},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Type 2 galactoside alpha-(1,2)-fucosyltransferase FUT2"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7876235"}],"value":"2.4.1.344"}]}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:4013"}],"value":"FUT2"},"synonyms":[{"value":"SEC2"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9JL27"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12692541"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21625510"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22068912"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24733310"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7876235"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8018146"}],"value":"Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the terminal galactose on both O- and N-linked glycans chains of cell surface glycoproteins and glycolipids and the resulting epitope regulates several processes such as cell-cell interaction including host-microbe interaction, cell surface expression and cell proliferation (PubMed:12692541, PubMed:7876235, PubMed:8018146). Preferentially fucosylates gangliosides GA1 and GM1 in the antrum, cecum and colon and in the female reproductive organs (By similarity). Fucosylated host glycoproteins or glycolipids mediate interaction with intestinal microbiota influencing its composition (PubMed:21625510, PubMed:22068912, PubMed:24733310). 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Vitamin B12 found in meat and milk products is necessary for the formation of red blood cells, DNA synthesis during cell division, and maintenance of the myelin nerve sheath, among other functions. Deficiency in vitamin B12, clinically associated with pernicious anemia, cardiovascular disease, cancer, and neurodegenerative disorders, is often related to poor intestinal B12 absorption rather than direct dietary deficiency"}],"commentType":"POLYMORPHISM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12692541"}],"value":"Genetic variation in FUT2 results in the non-secretor phenotype which gives rise to non-functional FUT2, resulting in a lack of the H type-1 oligosaccharide ligand in secretions, and this prevents Norwalk virus binding contributing to resistance to Norwalk virus infection"}],"commentType":"POLYMORPHISM"},{"texts":[{"value":"There are two genes (FUT1 and FUT2) which encode galactoside 2-L-fucosyltransferase. 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Preferentially fucosylates gangliosides GA1 and GM1 in the antrum, cecum and colon and in the female reproductive organs. Fucosylated host glycoproteins or glycolipids mediate interaction with intestinal microbiota influencing its composition. 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Preferentially fucosylates gangliosides GA1 and GM1 in the antrum, cecum and colon and in the female reproductive organs. Fucosylated host glycoproteins or glycolipids mediate interaction with intestinal microbiota influencing its composition. 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