{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P02794","secondaryAccessions":["B3KNR5","Q3KRA8","Q3SWW1"],"uniProtkbId":"FRIH_HUMAN","entryAudit":{"firstPublicDate":"1986-07-21","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2007-01-23","entryVersion":263,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Ferritin heavy chain"},"shortNames":[{"value":"Ferritin H subunit"}],"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9003196"}],"value":"1.16.3.1"}]},"alternativeNames":[{"fullName":{"value":"Cell proliferation-inducing gene 15 protein"}}],"contains":[{"recommendedName":{"fullName":{"value":"Ferritin heavy chain, N-terminally processed"}}}]},"genes":[{"geneName":{"value":"FTH1"},"synonyms":[{"value":"FTH"},{"value":"FTHL6"}],"orfNames":[{"value":"OK/SW-cl.84"},{"value":"PIG15"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P09528"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24695223"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26436293"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9003196"}],"value":"Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity (PubMed:9003196). Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation (PubMed:9003196). Also plays a role in delivery of iron to cells (By similarity). Mediates iron uptake in capsule cells of the developing kidney (By similarity). Delivery to lysosomes is mediated by the cargo receptor NCOA4 for autophagic degradation and release of iron (PubMed:24695223, PubMed:26436293)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:11148"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:15379"},{"database":"ChEBI","id":"CHEBI:29033"},{"database":"ChEBI","id":"CHEBI:29034"}],"ecNumber":"1.16.3.1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9003196"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24695223"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9159481"}],"value":"Oligomer of 24 subunits (PubMed:9159481). There are two types of subunits: L (light) chain and H (heavy) chain (PubMed:9159481). The major chain can be light or heavy, depending on the species and tissue type. In the human liver, the heavy chain is predominant (PubMed:9159481). The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited (PubMed:9159481). Interacts with NCOA4; NCOA4 promotes targeting of the iron-binding ferritin complex to autolysosomes following starvation or iron depletion (PubMed:24695223)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P02794","intActId":"EBI-713259"},"interactantTwo":{"uniProtKBAccession":"O95429","geneName":"BAG4","intActId":"EBI-2949658"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P02794","intActId":"EBI-713259"},"interactantTwo":{"uniProtKBAccession":"Q9UER7","geneName":"DAXX","intActId":"EBI-77321"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P02794","intActId":"EBI-713259"},"interactantTwo":{"uniProtKBAccession":"P02794","geneName":"FTH1","intActId":"EBI-713259"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P02794","intActId":"EBI-713259"},"interactantTwo":{"uniProtKBAccession":"P02792","geneName":"FTL","intActId":"EBI-713279"},"numberOfExperiments":20,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P02794","intActId":"EBI-713259"},"interactantTwo":{"uniProtKBAccession":"P51116","geneName":"FXR2","intActId":"EBI-740459"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P02794","intActId":"EBI-713259"},"interactantTwo":{"uniProtKBAccession":"P04792","geneName":"HSPB1","intActId":"EBI-352682"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P02794","intActId":"EBI-713259"},"interactantTwo":{"uniProtKBAccession":"P61244","geneName":"MAX","intActId":"EBI-751711"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P02794","intActId":"EBI-713259"},"interactantTwo":{"uniProtKBAccession":"Q13772","geneName":"NCOA4","intActId":"EBI-954501"},"numberOfExperiments":8,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P02794","intActId":"EBI-713259"},"interactantTwo":{"uniProtKBAccession":"P02786","geneName":"TFRC","intActId":"EBI-355727"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P02794","intActId":"EBI-713259"},"interactantTwo":{"uniProtKBAccession":"Q92574","geneName":"TSC1","intActId":"EBI-1047085"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P02794","intActId":"EBI-713259"},"interactantTwo":{"uniProtKBAccession":"Q2Q067","geneName":"HBZ","intActId":"EBI-9675545"},"numberOfExperiments":3,"organismDiffer":true}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26436293"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26436293"}],"value":"Lysosome","id":"SL-0158"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24695223"}],"value":"Cytoplasmic vesicle, autophagosome","id":"SL-0023"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11389486"}],"value":"Expressed in the liver"}],"commentType":"TISSUE SPECIFICITY"},{"commentType":"DISEASE","disease":{"diseaseId":"Hemochromatosis 5","diseaseAccession":"DI-03942","acronym":"HFE5","description":"A disorder of iron metabolism characterized by iron overload. Excess iron is deposited in a variety of organs leading to their failure, and resulting in serious illnesses including cirrhosis, hepatomas, diabetes, cardiomyopathy, arthritis, and hypogonadotropic hypogonadism. Severe effects of the disease usually do not appear until after decades of progressive iron loading.","diseaseCrossReference":{"database":"MIM","id":"615517"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11389486"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry. In a Japanese family affected by HFE5, a single point mutation has been detected in the iron-responsive element (IRE) in the 5'-UTR of FTH1 mRNA. This mutation leads to an increased binding affinity for iron regulatory protein and thereby to the efficient suppression of mRNA translation"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"Neurodegeneration with brain iron accumulation 9","diseaseAccession":"DI-06821","acronym":"NBIA9","description":"An autosomal dominant neurodegenerative disorder associated with iron accumulation, primarily in the basal ganglia. It is characterized by global developmental delay apparent from infancy, and progressive decline of motor and cognitive skills. Clinical features include delayed walking or inability to walk, spasticity with hyperreflexia, ataxia, dystonia, and poor or absent language.","diseaseCrossReference":{"database":"MIM","id":"620669"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37660254"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the ferritin family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"AAI05803.1","note":"Extended N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"WEB RESOURCE","resourceName":"Wikipedia","resourceUrl":"https://en.wikipedia.org/wiki/Ferritin","ftp":false,"note":"Ferritin entry"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":183,"modifier":"EXACT"}},"description":"Ferritin heavy chain","featureId":"PRO_0000201048"},{"type":"Initiator methionine","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"Removed; alternate","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"22814378"}]},{"type":"Chain","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":183,"modifier":"EXACT"}},"description":"Ferritin heavy chain, N-terminally processed","featureId":"PRO_0000424472"},{"type":"Domain","location":{"start":{"value":11,"modifier":"EXACT"},"end":{"value":160,"modifier":"EXACT"}},"description":"Ferritin-like diiron","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00085"}]},{"type":"Binding site","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":28,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:24875"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1992356"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"1FHA"}],"ligand":{"name":"Fe cation","id":"ChEBI:CHEBI:24875","label":"1"}},{"type":"Binding site","location":{"start":{"value":63,"modifier":"EXACT"},"end":{"value":63,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:24875"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1992356"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"1FHA"}],"ligand":{"name":"Fe cation","id":"ChEBI:CHEBI:24875","label":"1"}},{"type":"Binding site","location":{"start":{"value":63,"modifier":"EXACT"},"end":{"value":63,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:24875"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00085"}],"ligand":{"name":"Fe cation","id":"ChEBI:CHEBI:24875","label":"2"}},{"type":"Binding site","location":{"start":{"value":66,"modifier":"EXACT"},"end":{"value":66,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:24875"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1992356"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"1FHA"}],"ligand":{"name":"Fe cation","id":"ChEBI:CHEBI:24875","label":"1"}},{"type":"Binding site","location":{"start":{"value":108,"modifier":"EXACT"},"end":{"value":108,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:24875"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00085"}],"ligand":{"name":"Fe cation","id":"ChEBI:CHEBI:24875","label":"2"}},{"type":"Binding site","location":{"start":{"value":142,"modifier":"EXACT"},"end":{"value":142,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:24875"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00085"}],"ligand":{"name":"Fe cation","id":"ChEBI:CHEBI:24875","label":"2"}},{"type":"Site","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":23,"modifier":"EXACT"}},"description":"Essential for association with cargo receptor NCOA4","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26436293"}]},{"type":"Modified residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"N-acetylmethionine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"22814378"}]},{"type":"Modified residue","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":2,"modifier":"EXACT"}},"description":"N-acetylthreonine; in Ferritin heavy chain, N-terminally processed","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"22814378"}]},{"type":"Modified residue","location":{"start":{"value":179,"modifier":"EXACT"},"end":{"value":179,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"17081983"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18318008"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Modified residue","location":{"start":{"value":183,"modifier":"EXACT"},"end":{"value":183,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18318008"}]},{"type":"Mutagenesis","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":23,"modifier":"EXACT"}},"description":"Abrogates interaction with NCOA4. Fails to localize to punctate lysosomal structures.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26436293"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":28,"modifier":"EXACT"}},"description":"Reduces iron binding and oxidation rate; when associated with Q-87.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9003196"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":87,"modifier":"EXACT"},"end":{"value":87,"modifier":"EXACT"}},"description":"Reduces iron binding and oxidation rate; when associated with A-28. No effect on iron binding but the oxidation rate is severely reduced; when associated with A-108.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9003196"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["Q"]}},{"type":"Mutagenesis","location":{"start":{"value":108,"modifier":"EXACT"},"end":{"value":108,"modifier":"EXACT"}},"description":"No effect on iron binding but the oxidation rate is severely reduced; when associated with Q-87.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9003196"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["A"]}},{"type":"Sequence conflict","location":{"start":{"value":176,"modifier":"EXACT"},"end":{"value":183,"modifier":"EXACT"}},"description":"in Ref. 1; CAA25086","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"LGDSDNES","alternativeSequences":["WETVIMKAKPRANFP"]}},{"type":"Helix","location":{"start":{"value":5,"modifier":"EXACT"},"end":{"value":7,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8A5N"}]},{"type":"Helix","location":{"start":{"value":15,"modifier":"EXACT"},"end":{"value":42,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6B8F"}]},{"type":"Turn","location":{"start":{"value":45,"modifier":"EXACT"},"end":{"value":47,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6B8F"}]},{"type":"Helix","location":{"start":{"value":50,"modifier":"EXACT"},"end":{"value":77,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6B8F"}]},{"type":"Helix","location":{"start":{"value":79,"modifier":"EXACT"},"end":{"value":81,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8JAI"}]},{"type":"Helix","location":{"start":{"value":87,"modifier":"EXACT"},"end":{"value":89,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6B8F"}]},{"type":"Helix","location":{"start":{"value":97,"modifier":"EXACT"},"end":{"value":124,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6B8F"}]},{"type":"Helix","location":{"start":{"value":128,"modifier":"EXACT"},"end":{"value":134,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6B8F"}]},{"type":"Helix","location":{"start":{"value":135,"modifier":"EXACT"},"end":{"value":139,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6B8F"}]},{"type":"Helix","location":{"start":{"value":140,"modifier":"EXACT"},"end":{"value":158,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6B8F"}]},{"type":"Turn","location":{"start":{"value":159,"modifier":"EXACT"},"end":{"value":163,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6B8F"}]},{"type":"Helix","location":{"start":{"value":167,"modifier":"EXACT"},"end":{"value":174,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6B8F"}]},{"type":"Turn","location":{"start":{"value":175,"modifier":"EXACT"},"end":{"value":177,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7JGN"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0007","category":"PTM","name":"Acetylation"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0968","category":"Cellular component","name":"Cytoplasmic vesicle"},{"id":"KW-0408","category":"Ligand","name":"Iron"},{"id":"KW-0409","category":"Biological process","name":"Iron storage"},{"id":"KW-0458","category":"Cellular component","name":"Lysosome"},{"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"id":"KW-0523","category":"Disease","name":"Neurodegeneration"},{"id":"KW-0560","category":"Molecular function","name":"Oxidoreductase"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"6323167","citationType":"journal article","authors":["Costanzo F.","Santoro C.","Colantuoni V.","Bensi G.","Raugei G.","Romano V.","Cortese R."],"citationCrossReferences":[{"database":"PubMed","id":"6323167"},{"database":"DOI","id":"10.1002/j.1460-2075.1984.tb01756.x"}],"title":"Cloning and sequencing of a full length cDNA coding for a human apoferritin H chain: evidence for a multigene family.","publicationDate":"1984","journal":"EMBO J.","firstPage":"23","lastPage":"27","volume":"3"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"],"referenceComments":[{"value":"Hepatocyte","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"3840162","citationType":"journal article","authors":["Boyd D.","Vecoli C.","Belcher D.M.","Jain S.K.","Drysdale J.W."],"citationCrossReferences":[{"database":"PubMed","id":"3840162"},{"database":"DOI","id":"10.1016/s0021-9258(17)39094-4"}],"title":"Structural and functional relationships of human ferritin H and L chains deduced from cDNA clones.","publicationDate":"1985","journal":"J. Biol. Chem.","firstPage":"11755","lastPage":"11761","volume":"260"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"]},{"referenceNumber":3,"citation":{"id":"3023856","citationType":"journal article","authors":["Chou C.-C.","Gatti R.A.","Fuller M.L.","Concannon P.","Wong A.","Chada S.","Davis R.C.","Salser W.A."],"citationCrossReferences":[{"database":"PubMed","id":"3023856"},{"database":"DOI","id":"10.1128/mcb.6.2.566-573.1986"}],"title":"Structure and expression of ferritin genes in a human promyelocytic cell line that differentiates in vitro.","publicationDate":"1986","journal":"Mol. Cell. Biol.","firstPage":"566","lastPage":"573","volume":"6"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":4,"citation":{"id":"3003694","citationType":"journal article","authors":["Costanzo F.","Colombo M.","Staempfli S.","Santoro C.","Marone M.","Frank R.","Delius H.","Cortese R."],"citationCrossReferences":[{"database":"PubMed","id":"3003694"},{"database":"DOI","id":"10.1093/nar/14.2.721"}],"title":"Structure of gene and pseudogenes of human apoferritin H.","publicationDate":"1986","journal":"Nucleic Acids Res.","firstPage":"721","lastPage":"736","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":5,"citation":{"id":"3020541","citationType":"journal article","authors":["Hentze M.W.","Keim S.","Papadopoulos P.","O'Brien S.","Modi W.","Drysdale J.W.","Leonard W.J.","Harford J.B.","Klausner R.D."],"citationCrossReferences":[{"database":"PubMed","id":"3020541"},{"database":"DOI","id":"10.1073/pnas.83.19.7226"}],"title":"Cloning, characterization, expression, and chromosomal localization of a human ferritin heavy-chain gene.","publicationDate":"1986","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"7226","lastPage":"7230","volume":"83"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":6,"citation":{"id":"7916709","citationType":"journal article","authors":["Dhar M.","Chauthaiwale V.M.","Joshi J.G."],"citationCrossReferences":[{"database":"PubMed","id":"7916709"},{"database":"DOI","id":"10.1016/0378-1119(93)90380-l"}],"title":"Sequence of a cDNA encoding the ferritin H-chain from an 11-week-old human fetal brain.","publicationDate":"1993","journal":"Gene","firstPage":"275","lastPage":"278","volume":"126"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":7,"citation":{"id":"CI-596EP67H82RUI","citationType":"submission","authors":["Chauthaiwale V.M.","Dhar M.","McLachlan D.R.","Joshi J.G."],"title":"Cloning of a novel full length cDNA for ferritin heavy chain from normal adult human and Alzheimer's brain.","publicationDate":"JUL-1994","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":8,"citation":{"id":"CI-BSJKH68JBF06G","citationType":"submission","authors":["Franco A.V.","Gray C.P.","Myers K.","Hersey P."],"title":"Detection of ferritin heavy chain by SEREX: a multifunctional molecule in malignant tumour cells.","publicationDate":"AUG-1998","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"]},{"referenceNumber":9,"citation":{"id":"CI-91VIQ6GR5FR0H","citationType":"submission","authors":["Kim J.W."],"title":"Identification of a human cell proliferation gene 15.","publicationDate":"MAR-2003","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"]},{"referenceNumber":10,"citation":{"id":"CI-622I6T9164VV3","citationType":"submission","authors":["Shichijo S.","Itoh K."],"title":"Identification of immuno-peptidmics that are recognized by tumor-reactive CTL generated from TIL of colon cancer patients.","publicationDate":"MAY-2001","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Colon adenocarcinoma","type":"TISSUE"}]},{"referenceNumber":11,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Cerebellum","type":"TISSUE"}]},{"referenceNumber":12,"citation":{"id":"CI-7NVMUK7VSQ9P","citationType":"submission","authoringGroup":["NHLBI resequencing and genotyping service (RS&G)"],"publicationDate":"APR-2006","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":13,"citation":{"id":"CI-5GBDQ6B103N1E","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"JUL-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":14,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Brain","type":"TISSUE"},{"value":"Cervix","type":"TISSUE"},{"value":"Colon","type":"TISSUE"},{"value":"Lung","type":"TISSUE"},{"value":"Ovary","type":"TISSUE"},{"value":"Prostate","type":"TISSUE"},{"value":"Salivary gland","type":"TISSUE"}]},{"referenceNumber":15,"citation":{"id":"6589621","citationType":"journal article","authors":["Boyd D.","Jain S.K.","Crampton J.","Barrett K.J.","Drysdale J."],"citationCrossReferences":[{"database":"PubMed","id":"6589621"},{"database":"DOI","id":"10.1073/pnas.81.15.4751"}],"title":"Isolation and characterization of a cDNA clone for human ferritin heavy chain.","publicationDate":"1984","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"4751","lastPage":"4755","volume":"81"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF 128-183"]},{"referenceNumber":16,"citation":{"id":"9003196","citationType":"journal article","authors":["Treffry A.","Zhao Z.","Quail M.A.","Guest J.R.","Harrison P.M."],"citationCrossReferences":[{"database":"PubMed","id":"9003196"},{"database":"DOI","id":"10.1021/bi961830l"}],"title":"Dinuclear center of ferritin: studies of iron binding and oxidation show differences in the two iron sites.","publicationDate":"1997","journal":"Biochemistry","firstPage":"432","lastPage":"441","volume":"36"},"referencePositions":["FUNCTION","CATALYTIC ACTIVITY","MUTAGENESIS OF GLU-28; LYS-87 AND GLU-108"]},{"referenceNumber":17,"citation":{"id":"11389486","citationType":"journal article","authors":["Kato J.","Fujikawa K.","Kanda M.","Fukuda N.","Sasaki K.","Takayama T.","Kobune M.","Takada K.","Takimoto R.","Hamada H.","Ikeda T.","Niitsu Y."],"citationCrossReferences":[{"database":"PubMed","id":"11389486"},{"database":"DOI","id":"10.1086/321261"}],"title":"A mutation, in the iron-responsive element of H ferritin mRNA, causing autosomal dominant iron overload.","publicationDate":"2001","journal":"Am. J. Hum. Genet.","firstPage":"191","lastPage":"197","volume":"69"},"referencePositions":["TISSUE SPECIFICITY","INVOLVEMENT IN HFE5"]},{"referenceNumber":18,"citation":{"id":"17081983","citationType":"journal article","authors":["Olsen J.V.","Blagoev B.","Gnad F.","Macek B.","Kumar C.","Mortensen P.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"17081983"},{"database":"DOI","id":"10.1016/j.cell.2006.09.026"}],"title":"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.","publicationDate":"2006","journal":"Cell","firstPage":"635","lastPage":"648","volume":"127"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-179","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":19,"citation":{"id":"18669648","citationType":"journal article","authors":["Dephoure N.","Zhou C.","Villen J.","Beausoleil S.A.","Bakalarski C.E.","Elledge S.J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"18669648"},{"database":"DOI","id":"10.1073/pnas.0805139105"}],"title":"A quantitative atlas of mitotic phosphorylation.","publicationDate":"2008","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10762","lastPage":"10767","volume":"105"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":20,"citation":{"id":"18318008","citationType":"journal article","authors":["Han G.","Ye M.","Zhou H.","Jiang X.","Feng S.","Jiang X.","Tian R.","Wan D.","Zou H.","Gu J."],"citationCrossReferences":[{"database":"PubMed","id":"18318008"},{"database":"DOI","id":"10.1002/pmic.200700884"}],"title":"Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.","publicationDate":"2008","journal":"Proteomics","firstPage":"1346","lastPage":"1361","volume":"8"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-179 AND SER-183","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":21,"citation":{"id":"20068231","citationType":"journal article","authors":["Olsen J.V.","Vermeulen M.","Santamaria A.","Kumar C.","Miller M.L.","Jensen L.J.","Gnad F.","Cox J.","Jensen T.S.","Nigg E.A.","Brunak S.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"20068231"},{"database":"DOI","id":"10.1126/scisignal.2000475"}],"title":"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.","publicationDate":"2010","journal":"Sci. Signal.","firstPage":"RA3","lastPage":"RA3","volume":"3"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-179","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":22,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Buerckstuemmer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":23,"citation":{"id":"21406692","citationType":"journal article","authors":["Rigbolt K.T.","Prokhorova T.A.","Akimov V.","Henningsen J.","Johansen P.T.","Kratchmarova I.","Kassem M.","Mann M.","Olsen J.V.","Blagoev B."],"citationCrossReferences":[{"database":"PubMed","id":"21406692"},{"database":"DOI","id":"10.1126/scisignal.2001570"}],"title":"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.","publicationDate":"2011","journal":"Sci. Signal.","firstPage":"RS3","lastPage":"RS3","volume":"4"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-179","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":24,"citation":{"id":"22814378","citationType":"journal article","authors":["Van Damme P.","Lasa M.","Polevoda B.","Gazquez C.","Elosegui-Artola A.","Kim D.S.","De Juan-Pardo E.","Demeyer K.","Hole K.","Larrea E.","Timmerman E.","Prieto J.","Arnesen T.","Sherman F.","Gevaert K.","Aldabe R."],"citationCrossReferences":[{"database":"PubMed","id":"22814378"},{"database":"DOI","id":"10.1073/pnas.1210303109"}],"title":"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.","publicationDate":"2012","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"12449","lastPage":"12454","volume":"109"},"referencePositions":["ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1 AND THR-2","CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":25,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-179","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":26,"citation":{"id":"24695223","citationType":"journal article","authors":["Mancias J.D.","Wang X.","Gygi S.P.","Harper J.W.","Kimmelman A.C."],"citationCrossReferences":[{"database":"PubMed","id":"24695223"},{"database":"DOI","id":"10.1038/nature13148"}],"title":"Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy.","publicationDate":"2014","journal":"Nature","firstPage":"105","lastPage":"109","volume":"509"},"referencePositions":["FUNCTION","INTERACTION WITH NCOA4","SUBCELLULAR LOCATION"]},{"referenceNumber":27,"citation":{"id":"25944712","citationType":"journal article","authors":["Vaca Jacome A.S.","Rabilloud T.","Schaeffer-Reiss C.","Rompais M.","Ayoub D.","Lane L.","Bairoch A.","Van Dorsselaer A.","Carapito C."],"citationCrossReferences":[{"database":"PubMed","id":"25944712"},{"database":"DOI","id":"10.1002/pmic.201400617"}],"title":"N-terminome analysis of the human mitochondrial proteome.","publicationDate":"2015","journal":"Proteomics","firstPage":"2519","lastPage":"2524","volume":"15"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":28,"citation":{"id":"26436293","citationType":"journal article","authors":["Mancias J.D.","Pontano Vaites L.","Nissim S.","Biancur D.E.","Kim A.J.","Wang X.","Liu Y.","Goessling W.","Kimmelman A.C.","Harper J.W."],"citationCrossReferences":[{"database":"PubMed","id":"26436293"},{"database":"DOI","id":"10.7554/elife.10308"}],"title":"Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis.","publicationDate":"2015","journal":"Elife","firstPage":"0","lastPage":"0","volume":"4"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION","MUTAGENESIS OF ARG-23"]},{"referenceNumber":29,"citation":{"id":"37660254","citationType":"journal article","authors":["Shieh J.T.","Tintos-Hernandez J.A.","Murali C.N.","Penon-Portmann M.","Flores-Mendez M.","Santana A.","Bulos J.A.","Du K.","Dupuis L.","Damseh N.","Mendoza-Londono R.","Berera C.","Lee J.C.","Phillips J.J.","Alves C.A.P.F.","Dmochowski I.J.","Ortiz-Gonzalez X.R."],"citationCrossReferences":[{"database":"PubMed","id":"37660254"},{"database":"DOI","id":"10.1016/j.xhgg.2023.100236"}],"title":"Heterozygous Nonsense Variants in the Ferritin Heavy Chain Gene FTH1 Cause a Neuroferritinopathy.","publicationDate":"2023","journal":"HGG Adv.","firstPage":"100236","lastPage":"100236","volume":"4"},"referencePositions":["INVOLVEMENT IN NBIA9"]},{"referenceNumber":30,"citation":{"id":"1992356","citationType":"journal article","authors":["Lawson D.M.","Artymiuk P.J.","Yewdall S.J.","Smith J.M.A.","Livingstone J.C.","Treffry A.","Luzzago A.","Levi S.","Arosio P.","Cesarini G.","Thomas C.D.","Shaw W.V.","Harrison P.M."],"citationCrossReferences":[{"database":"PubMed","id":"1992356"},{"database":"DOI","id":"10.1038/349541a0"}],"title":"Solving the structure of human H ferritin by genetically engineering intermolecular crystal contacts.","publicationDate":"1991","journal":"Nature","firstPage":"541","lastPage":"544","volume":"349"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) IN COMPLEX WITH IRON"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"1FHA"}]},{"referenceNumber":31,"citation":{"id":"9159481","citationType":"journal article","authors":["Hempstead P.D.","Yewdall S.J.","Fernie A.R.","Lawson D.M.","Artymiuk P.J.","Rice D.W.","Ford G.C.","Harrison P.M."],"citationCrossReferences":[{"database":"PubMed","id":"9159481"},{"database":"DOI","id":"10.1006/jmbi.1997.0970"}],"title":"Comparison of the three-dimensional structures of recombinant human H and horse L ferritins at high resolution.","publicationDate":"1997","journal":"J. Mol. Biol.","firstPage":"424","lastPage":"448","volume":"268"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS)","SUBUNIT"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"2FHA"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"X00318","properties":[{"key":"ProteinId","value":"CAA25086.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"M11146","properties":[{"key":"ProteinId","value":"AAA52437.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"M12937","properties":[{"key":"ProteinId","value":"AAA35830.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"X03487","properties":[{"key":"ProteinId","value":"CAA27205.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"X03488","properties":[{"key":"ProteinId","value":"CAA27205.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M14212","properties":[{"key":"ProteinId","value":"AAA52438.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M14211","properties":[{"key":"ProteinId","value":"AAA52438.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M97164","properties":[{"key":"ProteinId","value":"AAA35832.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"L20941","properties":[{"key":"ProteinId","value":"AAA35833.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF088851","properties":[{"key":"ProteinId","value":"AAF89523.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AY258285","properties":[{"key":"ProteinId","value":"AAP82230.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AB062402","properties":[{"key":"ProteinId","value":"BAB93489.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK054816","properties":[{"key":"ProteinId","value":"BAG51427.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"DQ496108","properties":[{"key":"ProteinId","value":"ABF47097.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471076","properties":[{"key":"ProteinId","value":"EAW73989.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC000857","properties":[{"key":"ProteinId","value":"AAH00857.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC001399","properties":[{"key":"ProteinId","value":"AAH01399.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC011359","properties":[{"key":"ProteinId","value":"AAH11359.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC013724","properties":[{"key":"ProteinId","value":"AAH13724.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC015156","properties":[{"key":"ProteinId","value":"AAH15156.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC016009","properties":[{"key":"ProteinId","value":"AAH16009.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC016857","properties":[{"key":"ProteinId","value":"AAH16857.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC063514","properties":[{"key":"ProteinId","value":"AAH63514.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC066961","properties":[{"key":"ProteinId","value":"AAH66961.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC073750","properties":[{"key":"ProteinId","value":"AAH73750.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC104643","properties":[{"key":"ProteinId","value":"AAI04644.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC105802","properties":[{"key":"ProteinId","value":"AAI05803.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"M15383","properties":[{"key":"ProteinId","value":"AAA52479.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS41655.1","properties":[{"key":"Description","value":"-"}]},{"database":"PIR","id":"A23517","properties":[{"key":"EntryName","value":"FRHUH"}]},{"database":"RefSeq","id":"NP_002023.2","properties":[{"key":"NucleotideSequenceId","value":"NM_002032.3"}]},{"database":"PDB","id":"1FHA","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.40 A"},{"key":"Chains","value":"A=1-183"}]},{"database":"PDB","id":"2CEI","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A=1-183"}]},{"database":"PDB","id":"2CHI","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.60 A"},{"key":"Chains","value":"A=1-183"}]},{"database":"PDB","id":"2CIH","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.50 A"},{"key":"Chains","value":"A=1-183"}]},{"database":"PDB","id":"2CLU","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.10 A"},{"key":"Chains","value":"A=1-183"}]},{"database":"PDB","id":"2CN6","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.20 A"},{"key":"Chains","value":"A=1-183"}]},{"database":"PDB","id":"2CN7","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.75 A"},{"key":"Chains","value":"A=1-183"}]},{"database":"PDB","id":"2FHA","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A=1-183"}]},{"database":"PDB","id":"2IU2","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A=1-183"}]},{"database":"PDB","id":"2Z6M","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.72 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J/K/L=2-177"}]},{"database":"PDB","id":"3AJO","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.52 A"},{"key":"Chains","value":"A=2-183"}]},{"database":"PDB","id":"3AJP","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A=2-183"}]},{"database":"PDB","id":"3AJQ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.58 A"},{"key":"Chains","value":"A=2-183"}]},{"database":"PDB","id":"3ERZ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.06 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J/K/L=1-183"}]},{"database":"PDB","id":"3ES3","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.79 A"},{"key":"Chains","value":"A=1-183"}]},{"database":"PDB","id":"4DYX","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.85 A"},{"key":"Chains","value":"A=6-177"}]},{"database":"PDB","id":"4DYY","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A=6-177"}]},{"database":"PDB","id":"4DYZ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"A=6-177"}]},{"database":"PDB","id":"4DZ0","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"A=6-177"}]},{"database":"PDB","id":"4OYN","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.43 A"},{"key":"Chains","value":"A=1-183"}]},{"database":"PDB","id":"4Y08","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.34 A"},{"key":"Chains","value":"A=1-183"}]},{"database":"PDB","id":"4YKH","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.52 A"},{"key":"Chains","value":"A=1-183"}]},{"database":"PDB","id":"4ZJK","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.56 A"},{"key":"Chains","value":"A=2-183"}]},{"database":"PDB","id":"5CMQ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.94 A"},{"key":"Chains","value":"A=2-183"}]},{"database":"PDB","id":"5CMR","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.79 A"},{"key":"Chains","value":"A=2-183"}]},{"database":"PDB","id":"5GN8","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.81 A"},{"key":"Chains","value":"A=2-183, B=2-153"}]},{"database":"PDB","id":"5GOU","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.91 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P=1-183"}]},{"database":"PDB","id":"5JKK","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.60 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H=1-183"}]},{"database":"PDB","id":"5JKL","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J/K/L=1-183"}]},{"database":"PDB","id":"5JKM","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J/K/L=1-183"}]},{"database":"PDB","id":"5N26","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.05 A"},{"key":"Chains","value":"A=2-183"}]},{"database":"PDB","id":"5N27","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.74 A"},{"key":"Chains","value":"A=2-183"}]},{"database":"PDB","id":"5UP7","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.79 A"},{"key":"Chains","value":"A=2-183"}]},{"database":"PDB","id":"5UP8","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.63 A"},{"key":"Chains","value":"A=2-183"}]},{"database":"PDB","id":"5UP9","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.45 A"},{"key":"Chains","value":"A/B/C/D/E/F=2-183"}]},{"database":"PDB","id":"5VTD","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.95 A"},{"key":"Chains","value":"A=2-183"}]},{"database":"PDB","id":"5XB1","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.00 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X=1-160"}]},{"database":"PDB","id":"5YI5","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.00 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X=1-177"}]},{"database":"PDB","id":"5ZND","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.00 A"},{"key":"Chains","value":"A=1-134"}]},{"database":"PDB","id":"6B8F","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.06 A"},{"key":"Chains","value":"A=2-183"}]},{"database":"PDB","id":"6B8G","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.13 A"},{"key":"Chains","value":"A=2-183"}]},{"database":"PDB","id":"6FTV","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.58 A"},{"key":"Chains","value":"A=2-183"}]},{"database":"PDB","id":"6GSR","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"5.50 A"},{"key":"Chains","value":"Aa/Ac/Ad/Ae/Af/Ag/Ah/Ai/Aj/Ak/Al/Am/An/Ao/Ap/Ar/As/At/Au/Av/Aw/Ax/Ay/Az=2-183"}]},{"database":"PDB","id":"6H5I","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.90 A"},{"key":"Chains","value":"Aa/Ac/Ad/Ae/Af/Ag/Ah/Ai/Aj/Ak/Al/Am/An/Ao/Ap/Ar/As/At/Au/Av/Aw/Ax/Ay/Az=6-177"}]},{"database":"PDB","id":"6H6T","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J/K/L=1-183"}]},{"database":"PDB","id":"6H6U","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A/B/C/D/E/F=1-183"}]},{"database":"PDB","id":"6IPC","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"4.44 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P=2-183"}]},{"database":"PDB","id":"6IPO","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.00 A"},{"key":"Chains","value":"A/B=2-183"}]},{"database":"PDB","id":"6IPP","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.70 A"},{"key":"Chains","value":"A/B=2-183"}]},{"database":"PDB","id":"6IPQ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.10 A"},{"key":"Chains","value":"A=2-183"}]},{"database":"PDB","id":"6J4A","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.99 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J/K/L=1-183"}]},{"database":"PDB","id":"6J7G","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.87 A"},{"key":"Chains","value":"A/B/C/D/G/H/I/J/M/N/O/P/Q/R/S/T/W/X/Y/Z/a/b/e/f=2-183"}]},{"database":"PDB","id":"6JOB","properties":[{"key":"Method","value":"Other"},{"key":"Resolution","value":"2.93 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J/K/L=1-183"}]},{"database":"PDB","id":"6JPS","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.50 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X=2-183"}]},{"database":"PDB","id":"6KE2","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A=1-183"}]},{"database":"PDB","id":"6KE4","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"A=1-183"}]},{"database":"PDB","id":"6M52","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.60 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X=1-183"}]},{"database":"PDB","id":"6M54","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.40 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X=1-183"}]},{"database":"PDB","id":"6WYF","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.25 A"},{"key":"Chains","value":"A=2-183"}]},{"database":"PDB","id":"6WYG","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.27 A"},{"key":"Chains","value":"A/B/C/D=2-183"}]},{"database":"PDB","id":"6WYH","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.22 A"},{"key":"Chains","value":"A/B/C/D=2-183"}]},{"database":"PDB","id":"6Z6U","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"1.25 A"},{"key":"Chains","value":"1/2/4/6/A/B/E/F/G/H/I/K/M/O/P/Q/S/U/W/X/Y/a/e/r=1-183"}]},{"database":"PDB","id":"6Z9E","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"1.55 A"},{"key":"Chains","value":"1/2/4/6/A/B/E/F/G/H/I/K/M/O/P/Q/S/U/W/X/Y/a/e/r=1-183"}]},{"database":"PDB","id":"6Z9F","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"1.56 A"},{"key":"Chains","value":"1/2/4/6/A/B/E/F/G/H/I/K/M/O/P/Q/S/U/W/X/Y/a/e/r=1-183"}]},{"database":"PDB","id":"7A6A","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"1.15 A"},{"key":"Chains","value":"1/2/4/6/A/B/E/F/G/H/I/K/M/O/P/Q/S/U/W/X/Y/a/e/r=1-183"}]},{"database":"PDB","id":"7A6B","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"1.33 A"},{"key":"Chains","value":"1/2/4/6/A/B/E/F/G/H/I/K/M/O/P/Q/S/U/W/X/Y/a/e/r=1-183"}]},{"database":"PDB","id":"7CK8","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J/K/L=5-177"}]},{"database":"PDB","id":"7CK9","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.60 A"},{"key":"Chains","value":"A=6-177"}]},{"database":"PDB","id":"7JGK","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.68 A"},{"key":"Chains","value":"A=2-183"}]},{"database":"PDB","id":"7JGL","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.34 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X/a/b/c/d/e/f=2-183"}]},{"database":"PDB","id":"7JGM","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.31 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X/a/b/c/d/e/f=2-183"}]},{"database":"PDB","id":"7JGN","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.07 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X/a/b/c/d/e/f=2-183"}]},{"database":"PDB","id":"7JGO","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.08 A"},{"key":"Chains","value":"A=2-183"}]},{"database":"PDB","id":"7JGP","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"6.42 A"},{"key":"Chains","value":"A=2-183"}]},{"database":"PDB","id":"7JGQ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.01 A"},{"key":"Chains","value":"A=2-183"}]},{"database":"PDB","id":"7K26","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.70 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J/K/L=2-183"}]},{"database":"PDB","id":"7K3V","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"1.34 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X=6-177"}]},{"database":"PDB","id":"7K3W","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"1.36 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X=6-177"}]},{"database":"PDB","id":"7KE3","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.20 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J/K/L=1-183"}]},{"database":"PDB","id":"7KE5","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.80 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J/K/L=2-183"}]},{"database":"PDB","id":"7PF1","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.10 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X=4-177"}]},{"database":"PDB","id":"7R5O","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"1.60 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X=5-177"}]},{"database":"PDB","id":"7RRP","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"1.27 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X=6-177"}]},{"database":"PDB","id":"7V66","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"1.89 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X=6-177"}]},{"database":"PDB","id":"7VD8","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"1.96 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X=6-177"}]},{"database":"PDB","id":"7ZG7","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"1.77 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X=6-177"}]},{"database":"PDB","id":"8A2L","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"AAA=2-183"}]},{"database":"PDB","id":"8A2M","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.57 A"},{"key":"Chains","value":"AAA=2-183"}]},{"database":"PDB","id":"8A5N","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.52 A"},{"key":"Chains","value":"AAA=2-183"}]},{"database":"PDB","id":"8AAV","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H=2-183"}]},{"database":"PDB","id":"8B7O","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.17 A"},{"key":"Chains","value":"AAA=2-183"}]},{"database":"PDB","id":"8CPM","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"1.81 A"},{"key":"Chains","value":"1/2/4/6/A/B/E/F/G/H/I/K/M/O/P/Q/S/U/W/X/Y/a/e/r=5-177"}]},{"database":"PDB","id":"8CPS","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"1.82 A"},{"key":"Chains","value":"1/2/4/6/A/B/E/F/G/H/I/K/M/O/P/Q/S/U/W/X/Y/a/e/r=5-177"}]},{"database":"PDB","id":"8CPT","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"1.79 A"},{"key":"Chains","value":"1/2/4/6/A/B/E/F/G/H/I/K/M/O/P/Q/S/U/W/X/Y/a/e/r=5-177"}]},{"database":"PDB","id":"8CPU","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"1.76 A"},{"key":"Chains","value":"1/2/4/6/A/B/E/F/G/H/I/K/M/O/P/Q/S/U/W/X/Y/a/e/r=5-177"}]},{"database":"PDB","id":"8CPV","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"1.76 A"},{"key":"Chains","value":"1/2/4/6/A/B/E/F/G/H/I/K/M/O/P/Q/S/U/W/X/Y/a/e/r=5-177"}]},{"database":"PDB","id":"8CPW","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"1.79 A"},{"key":"Chains","value":"1/2/4/6/A/B/E/F/G/H/I/K/M/O/P/Q/S/U/W/X/Y/a/e/r=5-177"}]},{"database":"PDB","id":"8CPX","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"1.76 A"},{"key":"Chains","value":"1/2/4/6/A/B/E/F/G/H/I/K/M/O/P/Q/S/U/W/X/Y/a/e/r=5-177"}]},{"database":"PDB","id":"8DHX","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.92 A"},{"key":"Chains","value":"1/2/4/6/A/B/E/F/G/H/I/K/M/O/P/Q/S/U/W/X/Y/a/e/r=1-183"}]},{"database":"PDB","id":"8DNP","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.69 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X=1-183"}]},{"database":"PDB","id":"8F49","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X=6-177"}]},{"database":"PDB","id":"8F4L","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.40 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X=6-177"}]},{"database":"PDB","id":"8HHS","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.40 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X=6-177"}]},{"database":"PDB","id":"8J9L","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J/K/L=1-183"}]},{"database":"PDB","id":"8J9M","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.90 A"},{"key":"Chains","value":"A/B/C=1-183"}]},{"database":"PDB","id":"8JAI","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.56 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X=1-183"}]},{"database":"PDB","id":"8KFD","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A=2-183"}]},{"database":"PDB","id":"8PP2","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J/K/L=6-177"}]},{"database":"PDB","id":"8PP3","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.55 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J/K/L=1-183"}]},{"database":"PDB","id":"8PP4","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A/B/C/D/E/F=1-183, G/H/I/J/K/L=2-183"}]},{"database":"PDB","id":"8PP5","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A/B/C/D/E/F=6-177"}]},{"database":"PDB","id":"8QU9","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.88 A"},{"key":"Chains","value":"A=6-183"}]},{"database":"PDB","id":"8W92","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.12 A"},{"key":"Chains","value":"A=1-183"}]},{"database":"PDB","id":"8WB3","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.49 A"},{"key":"Chains","value":"A=1-183"}]},{"database":"PDB","id":"8WIE","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"A/B/C/D/E/F=1-177"}]},{"database":"PDB","id":"8WIQ","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.19 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X=1-183"}]},{"database":"PDB","id":"8WJF","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.02 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X=1-183"}]},{"database":"PDB","id":"8XWB","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.69 A"},{"key":"Chains","value":"A=6-177"}]},{"database":"PDB","id":"8Y6F","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.01 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J/K/L=1-182"}]},{"database":"PDB","id":"9EQC","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.60 A"},{"key":"Chains","value":"A=1-183"}]},{"database":"PDB","id":"9HQ6","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"1.51 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/V/W/X/Y=2-183"}]},{"database":"PDB","id":"9I19","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.63 A"},{"key":"Chains","value":"A=1-183"}]},{"database":"PDB","id":"9I1B","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.63 A"},{"key":"Chains","value":"A=2-183"}]},{"database":"PDB","id":"9I1C","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.58 A"},{"key":"Chains","value":"A=1-183"}]},{"database":"PDB","id":"9I1E","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.76 A"},{"key":"Chains","value":"A=1-183"}]},{"database":"PDB","id":"9IVP","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.00 A"},{"key":"Chains","value":"A/BA/C/DA/E/FA/G/HA/I/JA/K/LA/M/NA/O/PA/Q/RA/S/TA/V/VA/X/Z=20-177"}]},{"database":"PDB","id":"9J48","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.04 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/V/W/X/Y=14-177"}]},{"database":"PDB","id":"9JGO","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.85 A"},{"key":"Chains","value":"A=2-183"}]},{"database":"PDB","id":"9JGP","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.53 A"},{"key":"Chains","value":"A=2-183"}]},{"database":"PDB","id":"9JIU","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.28 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J/K/L=1-183"}]},{"database":"PDB","id":"9JQB","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"1.78 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X=1-183"}]},{"database":"PDB","id":"9JQC","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"1.73 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X=1-183"}]},{"database":"PDB","id":"9JQD","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"1.81 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X=1-183"}]},{"database":"PDB","id":"9JQE","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"1.83 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X=1-183"}]},{"database":"PDB","id":"9KAY","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"1.73 A"},{"key":"Chains","value":"Aa/Ab/Ac/Ad/Ae/Af/Ag/Ah/Ai/Aj/Ak/Al/Am/An/Ao/Ap/Aq/Ar/As/At/Au/Av/Aw/Ax=2-160"}]},{"database":"PDB","id":"9LNY","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.40 A"},{"key":"Chains","value":"A=6-177"}]},{"database":"PDB","id":"9LUW","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H=1-183"}]},{"database":"PDB","id":"9RGH","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.38 A"},{"key":"Chains","value":"AAA=2-183"}]},{"database":"PDB","id":"9RGI","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.54 A"},{"key":"Chains","value":"AAA=2-183"}]},{"database":"PDB","id":"9RGJ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.50 A"},{"key":"Chains","value":"AAA=2-183"}]},{"database":"PDB","id":"9SJR","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"1.99 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/V/W/X/Y=5-177"}]},{"database":"PDB","id":"9SJS","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.06 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/V/W/X/Y=5-177"}]},{"database":"PDB","id":"9SJT","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"1.96 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/V/W/X/Y=5-177"}]},{"database":"PDB","id":"9SJU","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.08 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/V/W/X/Y=5-177"}]},{"database":"PDB","id":"9SJV","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"1.89 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/V/W/X/Y=5-177"}]},{"database":"PDBsum","id":"1FHA","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2CEI","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2CHI","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2CIH","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2CLU","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2CN6","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2CN7","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2FHA","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2IU2","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2Z6M","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3AJO","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3AJP","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3AJQ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3ERZ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3ES3","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4DYX","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4DYY","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4DYZ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4DZ0","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4OYN","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4Y08","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4YKH","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4ZJK","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5CMQ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5CMR","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5GN8","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5GOU","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5JKK","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5JKL","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5JKM","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5N26","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5N27","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5UP7","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5UP8","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5UP9","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5VTD","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5XB1","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5YI5","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5ZND","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6B8F","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6B8G","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6FTV","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6GSR","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6H5I","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6H6T","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6H6U","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6IPC","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6IPO","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6IPP","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6IPQ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6J4A","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6J7G","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6JOB","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6JPS","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6KE2","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6KE4","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6M52","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6M54","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6WYF","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6WYG","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6WYH","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6Z6U","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6Z9E","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6Z9F","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7A6A","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7A6B","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7CK8","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7CK9","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7JGK","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7JGL","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7JGM","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7JGN","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7JGO","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7JGP","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7JGQ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7K26","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7K3V","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7K3W","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7KE3","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7KE5","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7PF1","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7R5O","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7RRP","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7V66","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7VD8","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7ZG7","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8A2L","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8A2M","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8A5N","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8AAV","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8B7O","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8CPM","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8CPS","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8CPT","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8CPU","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8CPV","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8CPW","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8CPX","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8DHX","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8DNP","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8F49","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8F4L","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8HHS","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8J9L","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8J9M","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8JAI","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8KFD","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8PP2","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8PP3","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8PP4","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8PP5","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8QU9","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8W92","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8WB3","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8WIE","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8WIQ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8WJF","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8XWB","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8Y6F","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9EQC","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9HQ6","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9I19","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9I1B","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9I1C","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9I1E","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9IVP","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9J48","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9JGO","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9JGP","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9JIU","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9JQB","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9JQC","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9JQD","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9JQE","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9KAY","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9LNY","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9LUW","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9RGH","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9RGI","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9RGJ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9SJR","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9SJS","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9SJT","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9SJU","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9SJV","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"P02794","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-0046","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-0140","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-11103","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-11121","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-11122","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-11668","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-11669","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-13364","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-14332","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-14705","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-16783","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-16784","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-16785","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-16786","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-16787","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-16788","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-16789","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-18658","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-22657","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-22658","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-24665","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-27437","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-27576","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-30083","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-30084","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-31736","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-31910","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-37566","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-37578","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-3853","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-3854","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-52339","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-54951","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-54952","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-54953","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-54954","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-54955","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-60931","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-61130","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-61726","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-61727","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-61728","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-61729","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-62216","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-6714","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-6830","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P02794","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"108773","properties":[{"key":"Interactions","value":"190"}]},{"database":"ComplexPortal","id":"CPX-26673","properties":[{"key":"EntryName","value":"FTH1-FTL, Ferritin complex"}]},{"database":"ComplexPortal","id":"CPX-26689","properties":[{"key":"EntryName","value":"Nuclear Ferritin complex, FTH1"}]},{"database":"CORUM","id":"P02794","properties":[{"key":"Description","value":"-"}]},{"database":"DIP","id":"DIP-38301N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P02794","properties":[{"key":"Number of interactors","value":"167"}]},{"database":"IntAct","id":"P02794","properties":[{"key":"Interactions","value":"149"}]},{"database":"MINT","id":"P02794","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-FTH1","properties":[{"key":"Evidences","value":"7 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000273550","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"P02794","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL6066220","properties":[{"key":"Description","value":"-"}]},{"database":"DrugBank","id":"DB13995","properties":[{"key":"GenericName","value":"Ferric pyrophosphate citrate"}]},{"database":"DrugBank","id":"DB14490","properties":[{"key":"GenericName","value":"Ferrous ascorbate"}]},{"database":"DrugBank","id":"DB14491","properties":[{"key":"GenericName","value":"Ferrous fumarate"}]},{"database":"DrugBank","id":"DB14488","properties":[{"key":"GenericName","value":"Ferrous gluconate"}]},{"database":"DrugBank","id":"DB14501","properties":[{"key":"GenericName","value":"Ferrous glycine sulfate"}]},{"database":"DrugBank","id":"DB14489","properties":[{"key":"GenericName","value":"Ferrous succinate"}]},{"database":"DrugBank","id":"DB06784","properties":[{"key":"GenericName","value":"Gallium citrate Ga-67"}]},{"database":"DrugBank","id":"DB01592","properties":[{"key":"GenericName","value":"Iron"}]},{"database":"DrugBank","id":"DB00893","properties":[{"key":"GenericName","value":"Iron Dextran"}]},{"database":"GlyGen","id":"P02794","properties":[{"key":"glycosylation","value":"3 sites, 2 N-linked glycans (1 site), 1 O-linked glycan (2 sites)"}]},{"database":"iPTMnet","id":"P02794","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"P02794","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"P02794","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"FTH1","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"120516","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"P02794","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"P02794","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000273550","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P02794","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"51600","properties":[{"key":"Description","value":"-"}]},{"database":"Pumba","id":"P02794","properties":[{"key":"Description","value":"-"}]},{"database":"TopDownProteomics","id":"P02794","properties":[{"key":"Description","value":"-"}]},{"database":"ABCD","id":"P02794","properties":[{"key":"antibodies","value":"5 sequenced antibodies"}]},{"database":"Antibodypedia","id":"28385","properties":[{"key":"antibodies","value":"912 antibodies from 44 providers"}]},{"database":"DNASU","id":"2495","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000273550.12","properties":[{"key":"ProteinId","value":"ENSP00000273550.7"},{"key":"GeneId","value":"ENSG00000167996.17"}]},{"database":"Ensembl","id":"ENST00000620041.5","properties":[{"key":"ProteinId","value":"ENSP00000484477.1"},{"key":"GeneId","value":"ENSG00000167996.17"}]},{"database":"GeneID","id":"2495","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:2495","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000273550.12","properties":[{"key":"ProteinId","value":"ENSP00000273550.7"},{"key":"RefSeqNucleotideId","value":"NM_002032.3"},{"key":"RefSeqProteinId","value":"NP_002023.2"}]},{"database":"UCSC","id":"uc001nsu.3","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:3976","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA28392","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"2495","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"2495","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"FTH1","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:3976","properties":[{"key":"GeneName","value":"FTH1"}]},{"database":"HPA","id":"ENSG00000167996","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MalaCards","id":"FTH1","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"134770","properties":[{"key":"Type","value":"gene"}]},{"database":"MIM","id":"615517","properties":[{"key":"Type","value":"phenotype"}]},{"database":"MIM","id":"620669","properties":[{"key":"Type","value":"phenotype"}]},{"database":"OpenTargets","id":"ENSG00000167996","properties":[{"key":"Description","value":"-"}]},{"database":"Orphanet","id":"247790","properties":[{"key":"Disease","value":"FTH1-related iron overload"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000167996","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG2332","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00950000182841","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_065681_4_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P02794","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"FFLKASM","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"186462at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"P02794","properties":[{"key":"Number of GO annotations","value":"4 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"P02794","properties":[{"key":"Description","value":"-"}]},{"database":"BRENDA","id":"1.16.3.1","properties":[{"key":"OrganismId","value":"2681"}]},{"database":"PathwayCommons","id":"P02794","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-3000480","properties":[{"key":"PathwayName","value":"Scavenging by Class A Receptors"}]},{"database":"Reactome","id":"R-HSA-432722","properties":[{"key":"PathwayName","value":"Golgi Associated Vesicle Biogenesis"}]},{"database":"Reactome","id":"R-HSA-6798695","properties":[{"key":"PathwayName","value":"Neutrophil degranulation"}]},{"database":"Reactome","id":"R-HSA-917937","properties":[{"key":"PathwayName","value":"Iron uptake and transport"}]},{"database":"SignaLink","id":"P02794","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"P02794","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000167996","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"2495","properties":[{"key":"hits","value":"81 hits in 1125 CRISPR screens"}]},{"database":"CD-CODE","id":"ECAD3DEA","properties":[{"key":"EntryName","value":"Ferritin-NCOA4 condensate"}]},{"database":"CD-CODE","id":"FB4E32DD","properties":[{"key":"EntryName","value":"Presynaptic clusters and postsynaptic densities"}]},{"database":"ChiTaRS","id":"FTH1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"P02794","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"FTH1","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"2495","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"P02794","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:P02794","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 11"}]},{"database":"RNAct","id":"P02794","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000167996","properties":[{"key":"ExpressionPatterns","value":"Expressed in stromal cell of endometrium and 198 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"P02794","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0044754","properties":[{"key":"GoTerm","value":"C:autolysosome"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"25327288"}]},{"database":"GO","id":"GO:0005776","properties":[{"key":"GoTerm","value":"C:autophagosome"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26436293"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0070062","properties":[{"key":"GoTerm","value":"C:extracellular exosome"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"19056867"},{"evidenceCode":"ECO:0007005","source":"PubMed","id":"23533145"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0070288","properties":[{"key":"GoTerm","value":"C:ferritin complex"},{"key":"GoEvidenceType","value":"IPI:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"33087927"}]},{"database":"GO","id":"GO:1904813","properties":[{"key":"GoTerm","value":"C:ficolin-1-rich granule lumen"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0005764","properties":[{"key":"GoTerm","value":"C:lysosome"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26436293"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"21630459"}]},{"database":"GO","id":"GO:1904724","properties":[{"key":"GoTerm","value":"C:tertiary granule lumen"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0008199","properties":[{"key":"GoTerm","value":"F:ferric iron binding"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0008198","properties":[{"key":"GoTerm","value":"F:ferrous iron binding"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"9003196"}]},{"database":"GO","id":"GO:0004322","properties":[{"key":"GoTerm","value":"F:ferroxidase activity"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"9003196"}]},{"database":"GO","id":"GO:0042802","properties":[{"key":"GoTerm","value":"F:identical protein binding"},{"key":"GoEvidenceType","value":"IPI:IntAct"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"25416956"},{"evidenceCode":"ECO:0000353","source":"PubMed","id":"31515488"},{"evidenceCode":"ECO:0000353","source":"PubMed","id":"33087927"}]},{"database":"GO","id":"GO:0005506","properties":[{"key":"GoTerm","value":"F:iron ion binding"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"3020541"}]},{"database":"GO","id":"GO:0140315","properties":[{"key":"GoTerm","value":"F:iron ion sequestering activity"},{"key":"GoEvidenceType","value":"IDA:GO_Central"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"9924025"}]},{"database":"GO","id":"GO:0006914","properties":[{"key":"GoTerm","value":"P:autophagy"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"38714719"}]},{"database":"GO","id":"GO:0030218","properties":[{"key":"GoTerm","value":"P:erythrocyte differentiation"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"26776506"}]},{"database":"GO","id":"GO:0006955","properties":[{"key":"GoTerm","value":"P:immune response"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0006879","properties":[{"key":"GoTerm","value":"P:intracellular iron ion homeostasis"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"6589621"}]},{"database":"GO","id":"GO:0006826","properties":[{"key":"GoTerm","value":"P:iron ion transport"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0008285","properties":[{"key":"GoTerm","value":"P:negative regulation of cell population proliferation"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0110076","properties":[{"key":"GoTerm","value":"P:negative regulation of ferroptosis"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"26403645"}]},{"database":"GO","id":"GO:0048147","properties":[{"key":"GoTerm","value":"P:negative regulation of fibroblast proliferation"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"9924025"}]},{"database":"CDD","id":"cd01056","properties":[{"key":"EntryName","value":"Euk_Ferritin"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.1260.10:FF:000024","properties":[{"key":"EntryName","value":"Ferritin heavy chain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1260.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001519","properties":[{"key":"EntryName","value":"Ferritin"}]},{"database":"InterPro","id":"IPR012347","properties":[{"key":"EntryName","value":"Ferritin-like"}]},{"database":"InterPro","id":"IPR009040","properties":[{"key":"EntryName","value":"Ferritin-like_diiron"}]},{"database":"InterPro","id":"IPR009078","properties":[{"key":"EntryName","value":"Ferritin-like_SF"}]},{"database":"InterPro","id":"IPR014034","properties":[{"key":"EntryName","value":"Ferritin_CS"}]},{"database":"InterPro","id":"IPR008331","properties":[{"key":"EntryName","value":"Ferritin_DPS_dom"}]},{"database":"PANTHER","id":"PTHR11431","properties":[{"key":"EntryName","value":"FERRITIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11431:SF37","properties":[{"key":"EntryName","value":"FERRITIN HEAVY CHAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00210","properties":[{"key":"EntryName","value":"Ferritin"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF47240","properties":[{"key":"EntryName","value":"Ferritin-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00540","properties":[{"key":"EntryName","value":"FERRITIN_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00204","properties":[{"key":"EntryName","value":"FERRITIN_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50905","properties":[{"key":"EntryName","value":"FERRITIN_LIKE"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MTTASTSQVRQNYHQDSEAAINRQINLELYASYVYLSMSYYFDRDDVALKNFAKYFLHQSHEEREHAEKLMKLQNQRGGRIFLQDIKKPDCDDWESGLNAMECALHLEKNVNQSLLELHKLATDKNDPHLCDFIETHYLNEQVKAIKELGDHVTNLRKMGAPESGLAEYLFDKHTLGDSDNES","length":183,"molWeight":21226,"crc64":"FEF75640A29CCF56","md5":"0A9AD101E9D8A8996656B21F0DCE6651"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"SUBUNIT":1,"INTERACTION":11,"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1,"DISEASE":2,"SIMILARITY":1,"SEQUENCE CAUTION":1,"WEB RESOURCE":1},"countByFeatureType":{"Chain":2,"Initiator methionine":1,"Domain":1,"Binding site":6,"Site":1,"Modified residue":4,"Mutagenesis":4,"Sequence conflict":1,"Helix":10,"Turn":3},"uniParcId":"UPI000000122C"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"G3V192","uniProtkbId":"G3V192_HUMAN","entryAudit":{"firstPublicDate":"2011-11-16","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-11-16","entryVersion":117,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000433321.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361145"}],"value":"Ferritin"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000433321.1"}],"value":"FTH1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361145"}],"value":"Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:11148"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:15379"},{"database":"ChEBI","id":"CHEBI:29033"},{"database":"ChEBI","id":"CHEBI:29034"}],"ecNumber":"1.16.3.1","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047990"}]}},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004419"}],"value":"Cytoplasmic vesicle, autophagosome","id":"SL-0023"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007513"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361145"}],"value":"Belongs to the ferritin family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00085"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":130,"modifier":"EXACT"}},"description":"Ferritin-like diiron","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50905"}]},{"type":"Binding site","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":33,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:24875"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601519-1"}],"ligand":{"name":"Fe cation","id":"ChEBI:CHEBI:24875","label":"1"}},{"type":"Binding site","location":{"start":{"value":36,"modifier":"EXACT"},"end":{"value":36,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:24875"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601519-1"}],"ligand":{"name":"Fe cation","id":"ChEBI:CHEBI:24875","label":"1"}},{"type":"Binding site","location":{"start":{"value":78,"modifier":"EXACT"},"end":{"value":78,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:24875"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601519-1"}],"ligand":{"name":"Fe cation","id":"ChEBI:CHEBI:24875","label":"1"}},{"type":"Binding site","location":{"start":{"value":112,"modifier":"EXACT"},"end":{"value":112,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:24875"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601519-1"}],"ligand":{"name":"Fe cation","id":"ChEBI:CHEBI:24875","label":"1"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023004"},{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601519-1"}],"id":"KW-0408","category":"Ligand","name":"Iron"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022434"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361145"}],"id":"KW-0409","category":"Biological process","name":"Iron storage"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"},{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601519-1"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023002"}],"id":"KW-0560","category":"Molecular function","name":"Oxidoreductase"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"G3V192"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"G3V192"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000433321.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000433321.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"17081983","citationType":"journal article","authors":["Olsen J.V.","Blagoev B.","Gnad F.","Macek B.","Kumar C.","Mortensen P.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"17081983"},{"database":"DOI","id":"10.1016/j.cell.2006.09.026"}],"title":"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.","publicationDate":"2006","journal":"Cell","firstPage":"635","lastPage":"648","volume":"127"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"17081983"}]},{"referenceNumber":4,"citation":{"id":"16554811","citationType":"journal article","authors":["Taylor T.D.","Noguchi H.","Totoki Y.","Toyoda A.","Kuroki Y.","Dewar K.","Lloyd C.","Itoh T.","Takeda T.","Kim D.W.","She X.","Barlow K.F.","Bloom T.","Bruford E.","Chang J.L.","Cuomo C.A.","Eichler E.","FitzGerald M.G.","Jaffe D.B.","LaButti K.","Nicol R.","Park H.S.","Seaman C.","Sougnez C.","Yang X.","Zimmer A.R.","Zody M.C.","Birren B.W.","Nusbaum C.","Fujiyama A.","Hattori M.","Rogers J.","Lander E.S.","Sakaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"16554811"},{"database":"DOI","id":"10.1038/nature04632"}],"title":"Human chromosome 11 DNA sequence and analysis including novel gene identification.","publicationDate":"2006","journal":"Nature","firstPage":"497","lastPage":"500","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000433321.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":5,"citation":{"id":"18669648","citationType":"journal article","authors":["Dephoure N.","Zhou C.","Villen J.","Beausoleil S.A.","Bakalarski C.E.","Elledge S.J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"18669648"},{"database":"DOI","id":"10.1073/pnas.0805139105"}],"title":"A quantitative atlas of mitotic phosphorylation.","publicationDate":"2008","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10762","lastPage":"10767","volume":"105"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"18669648"}]},{"referenceNumber":6,"citation":{"id":"18318008","citationType":"journal article","authors":["Han G.","Ye M.","Zhou H.","Jiang X.","Feng S.","Jiang X.","Tian R.","Wan D.","Zou H.","Gu J."],"citationCrossReferences":[{"database":"PubMed","id":"18318008"},{"database":"DOI","id":"10.1002/pmic.200700884"}],"title":"Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.","publicationDate":"2008","journal":"Proteomics","firstPage":"1346","lastPage":"1361","volume":"8"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"18318008"}]},{"referenceNumber":7,"citation":{"id":"20068231","citationType":"journal article","authors":["Olsen J.V.","Vermeulen M.","Santamaria A.","Kumar C.","Miller M.L.","Jensen L.J.","Gnad F.","Cox J.","Jensen T.S.","Nigg E.A.","Brunak S.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"20068231"},{"database":"DOI","id":"10.1126/scisignal.2000475"}],"title":"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.","publicationDate":"2010","journal":"Sci. Signal.","firstPage":"RA3","lastPage":"RA3","volume":"3"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"20068231"}]},{"referenceNumber":8,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Burckstummer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"21269460"}]},{"referenceNumber":9,"citation":{"id":"21406692","citationType":"journal article","authors":["Rigbolt K.T.","Prokhorova T.A.","Akimov V.","Henningsen J.","Johansen P.T.","Kratchmarova I.","Kassem M.","Mann M.","Olsen J.V.","Blagoev B."],"citationCrossReferences":[{"database":"PubMed","id":"21406692"},{"database":"DOI","id":"10.1126/scisignal.2001570"}],"title":"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.","publicationDate":"2011","journal":"Sci. Signal.","firstPage":"RS3","lastPage":"RS3","volume":"4"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"21406692"}]},{"referenceNumber":10,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"24275569"}]},{"referenceNumber":11,"citation":{"id":"25944712","citationType":"journal article","authors":["Vaca Jacome A.S.","Rabilloud T.","Schaeffer-Reiss C.","Rompais M.","Ayoub D.","Lane L.","Bairoch A.","Van Dorsselaer A.","Carapito C."],"citationCrossReferences":[{"database":"PubMed","id":"25944712"}],"title":"N-terminome analysis of the human mitochondrial proteome.","publicationDate":"2015","journal":"Proteomics","firstPage":"2519","lastPage":"2524","volume":"15"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"25944712"}]},{"referenceNumber":12,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000433321.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AP003733","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"G3V192","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"G3V192","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"32295","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"28385","properties":[{"key":"antibodies","value":"912 antibodies from 44 providers"}]},{"database":"Ensembl","id":"ENST00000526640.5","properties":[{"key":"ProteinId","value":"ENSP00000433321.1"},{"key":"GeneId","value":"ENSG00000167996.17"}]},{"database":"UCSC","id":"uc058cgq.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:3976","properties":[{"key":"GeneName","value":"FTH1"}]},{"database":"OpenTargets","id":"ENSG00000167996","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000167996","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00950000182841","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"186462at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"FTH1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 11"}]},{"database":"Bgee","id":"ENSG00000167996","properties":[{"key":"ExpressionPatterns","value":"Expressed in stromal cell of endometrium and 198 other cell types or tissues"}]},{"database":"GO","id":"GO:0005776","properties":[{"key":"GoTerm","value":"C:autophagosome"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0008199","properties":[{"key":"GoTerm","value":"F:ferric iron binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0004322","properties":[{"key":"GoTerm","value":"F:ferroxidase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0006879","properties":[{"key":"GoTerm","value":"P:intracellular iron ion homeostasis"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006826","properties":[{"key":"GoTerm","value":"P:iron ion transport"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd01056","properties":[{"key":"EntryName","value":"Euk_Ferritin"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.1260.10:FF:000016","properties":[{"key":"EntryName","value":"Ferritin heavy chain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1260.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001519","properties":[{"key":"EntryName","value":"Ferritin"}]},{"database":"InterPro","id":"IPR012347","properties":[{"key":"EntryName","value":"Ferritin-like"}]},{"database":"InterPro","id":"IPR009040","properties":[{"key":"EntryName","value":"Ferritin-like_diiron"}]},{"database":"InterPro","id":"IPR009078","properties":[{"key":"EntryName","value":"Ferritin-like_SF"}]},{"database":"InterPro","id":"IPR014034","properties":[{"key":"EntryName","value":"Ferritin_CS"}]},{"database":"InterPro","id":"IPR008331","properties":[{"key":"EntryName","value":"Ferritin_DPS_dom"}]},{"database":"PANTHER","id":"PTHR11431","properties":[{"key":"EntryName","value":"FERRITIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11431:SF37","properties":[{"key":"EntryName","value":"FERRITIN HEAVY CHAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00210","properties":[{"key":"EntryName","value":"Ferritin"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF47240","properties":[{"key":"EntryName","value":"Ferritin-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00540","properties":[{"key":"EntryName","value":"FERRITIN_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00204","properties":[{"key":"EntryName","value":"FERRITIN_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50905","properties":[{"key":"EntryName","value":"FERRITIN_LIKE"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MTTASTSQSYYFDRDDVALKNFAKYFLHQSHEEREHAEKLMKLQNQRGGRIFLQDIKKPDCDDWESGLNAMECALHLEKNVNQSLLELHKLATDKNDPHLCDFIETHYLNEQVKAIKELGDHVTNLRKMGAPESGLAEYLFDKHTLGDSDNES","length":153,"molWeight":17654,"crc64":"C03AB6C2421AF373","md5":"85593610C756F1B948F22D713E869E57"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Domain":1,"Binding site":4},"uniParcId":"UPI00001FA8FF"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q6NS36","uniProtkbId":"Q6NS36_HUMAN","entryAudit":{"firstPublicDate":"2004-07-05","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2004-07-05","entryVersion":127,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAH70494.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361145"}],"value":"Ferritin"}},"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAH70494.1"}],"value":"FTH1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361145"}],"value":"Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:11148"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:15379"},{"database":"ChEBI","id":"CHEBI:29033"},{"database":"ChEBI","id":"CHEBI:29034"}],"ecNumber":"1.16.3.1","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047990"}]}},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004419"}],"value":"Cytoplasmic vesicle, autophagosome","id":"SL-0023"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004371"}],"value":"Lysosome","id":"SL-0158"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007513"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361145"}],"value":"Belongs to the ferritin family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00085"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Domain","location":{"start":{"value":60,"modifier":"EXACT"},"end":{"value":209,"modifier":"EXACT"}},"description":"Ferritin-like diiron","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50905"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":29,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":19,"modifier":"EXACT"},"end":{"value":29,"modifier":"EXACT"}},"description":"Pro residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Binding site","location":{"start":{"value":77,"modifier":"EXACT"},"end":{"value":77,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:24875"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601519-1"}],"ligand":{"name":"Fe cation","id":"ChEBI:CHEBI:24875","label":"1"}},{"type":"Binding site","location":{"start":{"value":112,"modifier":"EXACT"},"end":{"value":112,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:24875"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601519-1"}],"ligand":{"name":"Fe cation","id":"ChEBI:CHEBI:24875","label":"1"}},{"type":"Binding site","location":{"start":{"value":115,"modifier":"EXACT"},"end":{"value":115,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:24875"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601519-1"}],"ligand":{"name":"Fe cation","id":"ChEBI:CHEBI:24875","label":"1"}},{"type":"Binding site","location":{"start":{"value":157,"modifier":"EXACT"},"end":{"value":157,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:24875"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601519-1"}],"ligand":{"name":"Fe cation","id":"ChEBI:CHEBI:24875","label":"1"}},{"type":"Binding site","location":{"start":{"value":191,"modifier":"EXACT"},"end":{"value":191,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:24875"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601519-1"}],"ligand":{"name":"Fe cation","id":"ChEBI:CHEBI:24875","label":"1"}},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAH70494.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023329"}],"id":"KW-0968","category":"Cellular component","name":"Cytoplasmic vesicle"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023004"},{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601519-1"}],"id":"KW-0408","category":"Ligand","name":"Iron"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022434"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361145"}],"id":"KW-0409","category":"Biological process","name":"Iron storage"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023228"}],"id":"KW-0458","category":"Cellular component","name":"Lysosome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"},{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601519-1"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023002"}],"id":"KW-0560","category":"Molecular function","name":"Oxidoreductase"}],"references":[{"referenceNumber":1,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"authors":["Gerhard D.S.","Wagner L.","Feingold E.A.","Shenmen C.M.","Grouse L.H.","Schuler G.","Klein S.L.","Old S.","Rasooly R.","Good P.","Guyer M.","Peck A.M.","Derge J.G.","Lipman D.","Collins F.S.","Jang W.","Sherry S.","Feolo M.","Misquitta L.","Lee E.","Rotmistrovsky K.","Greenhut S.F.","Schaefer C.F.","Buetow K.","Bonner T.I.","Haussler D.","Kent J.","Kiekhaus M.","Furey T.","Brent M.","Prange C.","Schreiber K.","Shapiro N.","Bhat N.K.","Hopkins R.F.","Hsie F.","Driscoll T.","Soares M.B.","Casavant T.L.","Scheetz T.E.","Brown-stein M.J.","Usdin T.B.","Toshiyuki S.","Carninci P.","Piao Y.","Dudekula D.B.","Ko M.S.","Kawakami K.","Suzuki Y.","Sugano S.","Gruber C.E.","Smith M.R.","Simmons B.","Moore T.","Waterman R.","Johnson S.L.","Ruan Y.","Wei C.L.","Mathavan S.","Gunaratne P.H.","Wu J.","Garcia A.M.","Hulyk S.W.","Fuh E.","Yuan Y.","Sneed A.","Kowis C.","Hodgson A.","Muzny D.M.","McPherson J.","Gibbs R.A.","Fahey J.","Helton E.","Ketteman M.","Madan A.","Rodrigues S.","Sanchez A.","Whiting M.","Madari A.","Young A.C.","Wetherby K.D.","Granite S.J.","Kwong P.N.","Brinkley C.P.","Pearson R.L.","Bouffard G.G.","Blakesly R.W.","Green E.D.","Dickson M.C.","Rodriguez A.C.","Grimwood J.","Schmutz J.","Myers R.M.","Butterfield Y.S.","Griffith M.","Griffith O.L.","Krzywinski M.I.","Liao N.","Morin R.","Morrin R.","Palmquist D.","Petrescu A.S.","Skalska U.","Smailus D.E.","Stott J.M.","Schnerch A.","Schein J.E.","Jones S.J.","Holt R.A.","Baross A.","Marra M.A.","Clifton S.","Makowski K.A.","Bosak S.","Malek J."],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAH70494.1"}],"value":"Lung","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAH70494.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"BC070494","properties":[{"key":"ProteinId","value":"AAH70494.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"Q6NS36","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q6NS36","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q6NS36","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"186462at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"Q6NS36","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"FTH1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GO","id":"GO:0005776","properties":[{"key":"GoTerm","value":"C:autophagosome"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005764","properties":[{"key":"GoTerm","value":"C:lysosome"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0008199","properties":[{"key":"GoTerm","value":"F:ferric iron binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0004322","properties":[{"key":"GoTerm","value":"F:ferroxidase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0006879","properties":[{"key":"GoTerm","value":"P:intracellular iron ion homeostasis"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006826","properties":[{"key":"GoTerm","value":"P:iron ion transport"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd01056","properties":[{"key":"EntryName","value":"Euk_Ferritin"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.1260.10:FF:000024","properties":[{"key":"EntryName","value":"Ferritin heavy chain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1260.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001519","properties":[{"key":"EntryName","value":"Ferritin"}]},{"database":"InterPro","id":"IPR012347","properties":[{"key":"EntryName","value":"Ferritin-like"}]},{"database":"InterPro","id":"IPR009040","properties":[{"key":"EntryName","value":"Ferritin-like_diiron"}]},{"database":"InterPro","id":"IPR009078","properties":[{"key":"EntryName","value":"Ferritin-like_SF"}]},{"database":"InterPro","id":"IPR014034","properties":[{"key":"EntryName","value":"Ferritin_CS"}]},{"database":"InterPro","id":"IPR008331","properties":[{"key":"EntryName","value":"Ferritin_DPS_dom"}]},{"database":"PANTHER","id":"PTHR11431","properties":[{"key":"EntryName","value":"FERRITIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11431:SF37","properties":[{"key":"EntryName","value":"FERRITIN HEAVY CHAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00210","properties":[{"key":"EntryName","value":"Ferritin"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF47240","properties":[{"key":"EntryName","value":"Ferritin-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00540","properties":[{"key":"EntryName","value":"FERRITIN_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00204","properties":[{"key":"EntryName","value":"FERRITIN_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50905","properties":[{"key":"EntryName","value":"FERRITIN_LIKE"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"SGFPASTVLGRNPALVPHPGRPPIASPPSPLHRTLGLPQGPRRLSLVAAMTTASTSQVRQNYHQDSEAAINRQINLELYASYVYLSMSYYFDRDDVALKNFAKYFLHQSHEEREHAEKLMKLQNQRGGRIFLQDIKKPDCDDWESGLNAMECALHLEKNVNQSLLELHKLATDKNDPHLCDFIETHYLNEQVKAIKELGDHVTNLRKMGAPESGLAEYLFDKHTLGDSDNES","length":232,"molWeight":26219,"crc64":"6C17564616345A85","md5":"AF39C9CEC9C75615A58A00FA11AB86C8"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Domain":1,"Region":1,"Compositional bias":1,"Binding site":5,"Non-terminal residue":1},"uniParcId":"UPI000035ECF1"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q6NZ44","uniProtkbId":"Q6NZ44_HUMAN","entryAudit":{"firstPublicDate":"2004-07-05","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2004-07-05","entryVersion":119,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAH66341.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361145"}],"value":"Ferritin"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAH66341.1"}],"value":"FTH1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361145"}],"value":"Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:11148"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:15379"},{"database":"ChEBI","id":"CHEBI:29033"},{"database":"ChEBI","id":"CHEBI:29034"}],"ecNumber":"1.16.3.1","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047990"}]}},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q6NZ44","intActId":"EBI-10180219"},"interactantTwo":{"uniProtKBAccession":"P02792","geneName":"FTL","intActId":"EBI-713279"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q6NZ44","intActId":"EBI-10180219"},"interactantTwo":{"uniProtKBAccession":"Q96HA8","geneName":"NTAQ1","intActId":"EBI-741158"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q6NZ44","intActId":"EBI-10180219"},"interactantTwo":{"uniProtKBAccession":"O00560","geneName":"SDCBP","intActId":"EBI-727004"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004419"}],"value":"Cytoplasmic vesicle, autophagosome","id":"SL-0023"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004371"}],"value":"Lysosome","id":"SL-0158"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007513"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361145"}],"value":"Belongs to the ferritin family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00085"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Domain","location":{"start":{"value":11,"modifier":"EXACT"},"end":{"value":160,"modifier":"EXACT"}},"description":"Ferritin-like diiron","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50905"}]},{"type":"Binding site","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":28,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:24875"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601519-1"}],"ligand":{"name":"Fe cation","id":"ChEBI:CHEBI:24875","label":"1"}},{"type":"Binding site","location":{"start":{"value":63,"modifier":"EXACT"},"end":{"value":63,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:24875"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601519-1"}],"ligand":{"name":"Fe cation","id":"ChEBI:CHEBI:24875","label":"1"}},{"type":"Binding site","location":{"start":{"value":66,"modifier":"EXACT"},"end":{"value":66,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:24875"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601519-1"}],"ligand":{"name":"Fe cation","id":"ChEBI:CHEBI:24875","label":"1"}},{"type":"Binding site","location":{"start":{"value":108,"modifier":"EXACT"},"end":{"value":108,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:24875"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601519-1"}],"ligand":{"name":"Fe cation","id":"ChEBI:CHEBI:24875","label":"2"}},{"type":"Binding site","location":{"start":{"value":142,"modifier":"EXACT"},"end":{"value":142,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:24875"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601519-1"}],"ligand":{"name":"Fe cation","id":"ChEBI:CHEBI:24875","label":"2"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023329"}],"id":"KW-0968","category":"Cellular component","name":"Cytoplasmic vesicle"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023004"},{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601519-1"}],"id":"KW-0408","category":"Ligand","name":"Iron"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022434"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361145"}],"id":"KW-0409","category":"Biological process","name":"Iron storage"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023228"}],"id":"KW-0458","category":"Cellular component","name":"Lysosome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"},{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601519-1"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023002"}],"id":"KW-0560","category":"Molecular function","name":"Oxidoreductase"}],"references":[{"referenceNumber":1,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"authors":["Gerhard D.S.","Wagner L.","Feingold E.A.","Shenmen C.M.","Grouse L.H.","Schuler G.","Klein S.L.","Old S.","Rasooly R.","Good P.","Guyer M.","Peck A.M.","Derge J.G.","Lipman D.","Collins F.S.","Jang W.","Sherry S.","Feolo M.","Misquitta L.","Lee E.","Rotmistrovsky K.","Greenhut S.F.","Schaefer C.F.","Buetow K.","Bonner T.I.","Haussler D.","Kent J.","Kiekhaus M.","Furey T.","Brent M.","Prange C.","Schreiber K.","Shapiro N.","Bhat N.K.","Hopkins R.F.","Hsie F.","Driscoll T.","Soares M.B.","Casavant T.L.","Scheetz T.E.","Brown-stein M.J.","Usdin T.B.","Toshiyuki S.","Carninci P.","Piao Y.","Dudekula D.B.","Ko M.S.","Kawakami K.","Suzuki Y.","Sugano S.","Gruber C.E.","Smith M.R.","Simmons B.","Moore T.","Waterman R.","Johnson S.L.","Ruan Y.","Wei C.L.","Mathavan S.","Gunaratne P.H.","Wu J.","Garcia A.M.","Hulyk S.W.","Fuh E.","Yuan Y.","Sneed A.","Kowis C.","Hodgson A.","Muzny D.M.","McPherson J.","Gibbs R.A.","Fahey J.","Helton E.","Ketteman M.","Madan A.","Rodrigues S.","Sanchez A.","Whiting M.","Madari A.","Young A.C.","Wetherby K.D.","Granite S.J.","Kwong P.N.","Brinkley C.P.","Pearson R.L.","Bouffard G.G.","Blakesly R.W.","Green E.D.","Dickson M.C.","Rodriguez A.C.","Grimwood J.","Schmutz J.","Myers R.M.","Butterfield Y.S.","Griffith M.","Griffith O.L.","Krzywinski M.I.","Liao N.","Morin R.","Morrin R.","Palmquist D.","Petrescu A.S.","Skalska U.","Smailus D.E.","Stott J.M.","Schnerch A.","Schein J.E.","Jones S.J.","Holt R.A.","Baross A.","Marra M.A.","Clifton S.","Makowski K.A.","Bosak S.","Malek J."],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAH66341.1"}],"value":"Brain","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAH66341.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"BC066341","properties":[{"key":"ProteinId","value":"AAH66341.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"Q6NZ44","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q6NZ44","properties":[{"key":"Description","value":"-"}]},{"database":"IntAct","id":"Q6NZ44","properties":[{"key":"Interactions","value":"3"}]},{"database":"OrthoDB","id":"186462at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"FTH1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GO","id":"GO:0005776","properties":[{"key":"GoTerm","value":"C:autophagosome"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005764","properties":[{"key":"GoTerm","value":"C:lysosome"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0008199","properties":[{"key":"GoTerm","value":"F:ferric iron binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0004322","properties":[{"key":"GoTerm","value":"F:ferroxidase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0006879","properties":[{"key":"GoTerm","value":"P:intracellular iron ion homeostasis"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006826","properties":[{"key":"GoTerm","value":"P:iron ion transport"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd01056","properties":[{"key":"EntryName","value":"Euk_Ferritin"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.1260.10:FF:000024","properties":[{"key":"EntryName","value":"Ferritin heavy chain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1260.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001519","properties":[{"key":"EntryName","value":"Ferritin"}]},{"database":"InterPro","id":"IPR012347","properties":[{"key":"EntryName","value":"Ferritin-like"}]},{"database":"InterPro","id":"IPR009040","properties":[{"key":"EntryName","value":"Ferritin-like_diiron"}]},{"database":"InterPro","id":"IPR009078","properties":[{"key":"EntryName","value":"Ferritin-like_SF"}]},{"database":"InterPro","id":"IPR014034","properties":[{"key":"EntryName","value":"Ferritin_CS"}]},{"database":"InterPro","id":"IPR008331","properties":[{"key":"EntryName","value":"Ferritin_DPS_dom"}]},{"database":"PANTHER","id":"PTHR11431","properties":[{"key":"EntryName","value":"FERRITIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11431:SF37","properties":[{"key":"EntryName","value":"FERRITIN HEAVY CHAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00210","properties":[{"key":"EntryName","value":"Ferritin"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF47240","properties":[{"key":"EntryName","value":"Ferritin-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00540","properties":[{"key":"EntryName","value":"FERRITIN_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00204","properties":[{"key":"EntryName","value":"FERRITIN_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50905","properties":[{"key":"EntryName","value":"FERRITIN_LIKE"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MTTASTSQVRQNYHQDSEAAINRQINLELYASYVYLSMSYYFDRDDVALKNFAKYFLHQSHEEREHAEKLMKLQNQRGGRIFLQDIKEPDCDDWESGQNAMECALHLEKNVNQSLLELHKLATDKNDPHLCDFIETHYLNEQVKAIKELGDHVTNLRKMGAPESGLAEYLFDKHTLGDSDNES","length":183,"molWeight":21242,"crc64":"4512E8078A2320B2","md5":"2368E00508052100D1A3A689C46CC120"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"INTERACTION":3,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Domain":1,"Binding site":5},"uniParcId":"UPI000023C873"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"E9PKY7","uniProtkbId":"E9PKY7_HUMAN","entryAudit":{"firstPublicDate":"2011-04-05","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-04-05","entryVersion":94,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000433470.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361145"}],"value":"Ferritin"}},"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000433470.1"}],"value":"FTH1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361145"}],"value":"Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:11148"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:15379"},{"database":"ChEBI","id":"CHEBI:29033"},{"database":"ChEBI","id":"CHEBI:29034"}],"ecNumber":"1.16.3.1","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047990"}]}},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004419"}],"value":"Cytoplasmic vesicle, autophagosome","id":"SL-0023"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004371"}],"value":"Lysosome","id":"SL-0158"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007513"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361145"}],"value":"Belongs to the ferritin family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00085"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Domain","location":{"start":{"value":11,"modifier":"EXACT"},"end":{"value":114,"modifier":"EXACT"}},"description":"Ferritin-like diiron","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50905"}]},{"type":"Binding site","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":28,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:24875"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601519-1"}],"ligand":{"name":"Fe cation","id":"ChEBI:CHEBI:24875","label":"1"}},{"type":"Binding site","location":{"start":{"value":63,"modifier":"EXACT"},"end":{"value":63,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:24875"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601519-1"}],"ligand":{"name":"Fe cation","id":"ChEBI:CHEBI:24875","label":"1"}},{"type":"Binding site","location":{"start":{"value":66,"modifier":"EXACT"},"end":{"value":66,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:24875"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601519-1"}],"ligand":{"name":"Fe cation","id":"ChEBI:CHEBI:24875","label":"1"}},{"type":"Non-terminal residue","location":{"start":{"value":114,"modifier":"EXACT"},"end":{"value":114,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000433470.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023329"}],"id":"KW-0968","category":"Cellular component","name":"Cytoplasmic vesicle"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023004"},{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601519-1"}],"id":"KW-0408","category":"Ligand","name":"Iron"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022434"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361145"}],"id":"KW-0409","category":"Biological process","name":"Iron storage"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023228"}],"id":"KW-0458","category":"Cellular component","name":"Lysosome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"},{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601519-1"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023002"}],"id":"KW-0560","category":"Molecular function","name":"Oxidoreductase"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"E9PKY7"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"E9PKY7"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000433470.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000433470.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16554811","citationType":"journal article","authors":["Taylor T.D.","Noguchi H.","Totoki Y.","Toyoda A.","Kuroki Y.","Dewar K.","Lloyd C.","Itoh T.","Takeda T.","Kim D.W.","She X.","Barlow K.F.","Bloom T.","Bruford E.","Chang J.L.","Cuomo C.A.","Eichler E.","FitzGerald M.G.","Jaffe D.B.","LaButti K.","Nicol R.","Park H.S.","Seaman C.","Sougnez C.","Yang X.","Zimmer A.R.","Zody M.C.","Birren B.W.","Nusbaum C.","Fujiyama A.","Hattori M.","Rogers J.","Lander E.S.","Sakaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"16554811"},{"database":"DOI","id":"10.1038/nature04632"}],"title":"Human chromosome 11 DNA sequence and analysis including novel gene identification.","publicationDate":"2006","journal":"Nature","firstPage":"497","lastPage":"500","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000433470.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Burckstummer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"21269460"}]},{"referenceNumber":5,"citation":{"id":"22814378","citationType":"journal article","authors":["Van Damme P.","Lasa M.","Polevoda B.","Gazquez C.","Elosegui-Artola A.","Kim D.S.","De Juan-Pardo E.","Demeyer K.","Hole K.","Larrea E.","Timmerman E.","Prieto J.","Arnesen T.","Sherman F.","Gevaert K.","Aldabe R."],"citationCrossReferences":[{"database":"PubMed","id":"22814378"},{"database":"DOI","id":"10.1073/pnas.1210303109"}],"title":"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.","publicationDate":"2012","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"12449","lastPage":"12454","volume":"109"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"22814378"}]},{"referenceNumber":6,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"24275569"}]},{"referenceNumber":7,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000433470.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AP003733","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"E9PKY7","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"E9PKY7","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"E9PKY7","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"21622","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"28385","properties":[{"key":"antibodies","value":"912 antibodies from 44 providers"}]},{"database":"Ensembl","id":"ENST00000530019.5","properties":[{"key":"ProteinId","value":"ENSP00000433470.1"},{"key":"GeneId","value":"ENSG00000167996.17"}]},{"database":"UCSC","id":"uc058cgm.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:3976","properties":[{"key":"GeneName","value":"FTH1"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000167996","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00950000182841","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"186462at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"FTH1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 11"}]},{"database":"Bgee","id":"ENSG00000167996","properties":[{"key":"ExpressionPatterns","value":"Expressed in stromal cell of endometrium and 198 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"E9PKY7","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005776","properties":[{"key":"GoTerm","value":"C:autophagosome"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005764","properties":[{"key":"GoTerm","value":"C:lysosome"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0008199","properties":[{"key":"GoTerm","value":"F:ferric iron binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0004322","properties":[{"key":"GoTerm","value":"F:ferroxidase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0006879","properties":[{"key":"GoTerm","value":"P:intracellular iron ion homeostasis"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006826","properties":[{"key":"GoTerm","value":"P:iron ion transport"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd01056","properties":[{"key":"EntryName","value":"Euk_Ferritin"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.1260.10:FF:000024","properties":[{"key":"EntryName","value":"Ferritin heavy chain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1260.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001519","properties":[{"key":"EntryName","value":"Ferritin"}]},{"database":"InterPro","id":"IPR012347","properties":[{"key":"EntryName","value":"Ferritin-like"}]},{"database":"InterPro","id":"IPR009040","properties":[{"key":"EntryName","value":"Ferritin-like_diiron"}]},{"database":"InterPro","id":"IPR009078","properties":[{"key":"EntryName","value":"Ferritin-like_SF"}]},{"database":"InterPro","id":"IPR014034","properties":[{"key":"EntryName","value":"Ferritin_CS"}]},{"database":"InterPro","id":"IPR008331","properties":[{"key":"EntryName","value":"Ferritin_DPS_dom"}]},{"database":"PANTHER","id":"PTHR11431","properties":[{"key":"EntryName","value":"FERRITIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11431:SF37","properties":[{"key":"EntryName","value":"FERRITIN HEAVY CHAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00210","properties":[{"key":"EntryName","value":"Ferritin"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF47240","properties":[{"key":"EntryName","value":"Ferritin-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00540","properties":[{"key":"EntryName","value":"FERRITIN_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50905","properties":[{"key":"EntryName","value":"FERRITIN_LIKE"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MTTASTSQVRQNYHQDSEAAINRQINLELYASYVYLSMSYYFDRDDVALKNFAKYFLHQSHEEREHAEKLMKLQNQRGGRIFLQDIKPTGTPGHQGQKKSHRKIIPGRTLYVPD","length":114,"molWeight":13346,"crc64":"AFC2CC1590F2D86B","md5":"2874799A5A0A37F3818B5856B7282F25"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Domain":1,"Binding site":3,"Non-terminal residue":1},"uniParcId":"UPI0001F77B8A"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"E9PPQ4","uniProtkbId":"E9PPQ4_HUMAN","entryAudit":{"firstPublicDate":"2011-04-05","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-04-05","entryVersion":91,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000436947.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361145"}],"value":"Ferritin"}},"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000436947.1"}],"value":"FTH1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361145"}],"value":"Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:11148"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:15379"},{"database":"ChEBI","id":"CHEBI:29033"},{"database":"ChEBI","id":"CHEBI:29034"}],"ecNumber":"1.16.3.1","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047990"}]}},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004419"}],"value":"Cytoplasmic vesicle, autophagosome","id":"SL-0023"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007513"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361145"}],"value":"Belongs to the ferritin family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":58,"modifier":"EXACT"}},"description":"Ferritin-like diiron","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50905"}]},{"type":"Binding site","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"axial binding residue","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:60344"},{"database":"ChEBI","id":"CHEBI:18248"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00085"}],"ligand":{"name":"heme b","id":"ChEBI:CHEBI:60344"},"ligandPart":{"name":"Fe","id":"ChEBI:CHEBI:18248"}},{"type":"Binding site","location":{"start":{"value":38,"modifier":"EXACT"},"end":{"value":38,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:24875"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601519-1"}],"ligand":{"name":"Fe cation","id":"ChEBI:CHEBI:24875","label":"1"}},{"type":"Non-terminal residue","location":{"start":{"value":58,"modifier":"EXACT"},"end":{"value":58,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000436947.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023004"},{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601519-1"}],"id":"KW-0408","category":"Ligand","name":"Iron"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022434"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361145"}],"id":"KW-0409","category":"Biological process","name":"Iron storage"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"},{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601519-1"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"E9PPQ4"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"E9PPQ4"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000436947.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000436947.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16554811","citationType":"journal article","authors":["Taylor T.D.","Noguchi H.","Totoki Y.","Toyoda A.","Kuroki Y.","Dewar K.","Lloyd C.","Itoh T.","Takeda T.","Kim D.W.","She X.","Barlow K.F.","Bloom T.","Bruford E.","Chang J.L.","Cuomo C.A.","Eichler E.","FitzGerald M.G.","Jaffe D.B.","LaButti K.","Nicol R.","Park H.S.","Seaman C.","Sougnez C.","Yang X.","Zimmer A.R.","Zody M.C.","Birren B.W.","Nusbaum C.","Fujiyama A.","Hattori M.","Rogers J.","Lander E.S.","Sakaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"16554811"},{"database":"DOI","id":"10.1038/nature04632"}],"title":"Human chromosome 11 DNA sequence and analysis including novel gene identification.","publicationDate":"2006","journal":"Nature","firstPage":"497","lastPage":"500","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000436947.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Burckstummer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"21269460"}]},{"referenceNumber":5,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"24275569"}]},{"referenceNumber":6,"citation":{"id":"25944712","citationType":"journal article","authors":["Vaca Jacome A.S.","Rabilloud T.","Schaeffer-Reiss C.","Rompais M.","Ayoub D.","Lane L.","Bairoch A.","Van Dorsselaer A.","Carapito C."],"citationCrossReferences":[{"database":"PubMed","id":"25944712"}],"title":"N-terminome analysis of the human mitochondrial proteome.","publicationDate":"2015","journal":"Proteomics","firstPage":"2519","lastPage":"2524","volume":"15"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"25944712"}]},{"referenceNumber":7,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000436947.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AP003733","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"E9PPQ4","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"E9PPQ4","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"E9PPQ4","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"22789","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"28385","properties":[{"key":"antibodies","value":"912 antibodies from 44 providers"}]},{"database":"Ensembl","id":"ENST00000529548.1","properties":[{"key":"ProteinId","value":"ENSP00000436947.1"},{"key":"GeneId","value":"ENSG00000167996.17"}]},{"database":"UCSC","id":"uc058cgu.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:3976","properties":[{"key":"GeneName","value":"FTH1"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000167996","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00950000182841","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_2984169_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"FFLKASM","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"186462at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"FTH1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 11"}]},{"database":"Bgee","id":"ENSG00000167996","properties":[{"key":"ExpressionPatterns","value":"Expressed in stromal cell of endometrium and 198 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"E9PPQ4","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005776","properties":[{"key":"GoTerm","value":"C:autophagosome"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0008199","properties":[{"key":"GoTerm","value":"F:ferric iron binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0004322","properties":[{"key":"GoTerm","value":"F:ferroxidase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0006879","properties":[{"key":"GoTerm","value":"P:intracellular iron ion homeostasis"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006826","properties":[{"key":"GoTerm","value":"P:iron ion transport"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"1.20.1260.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001519","properties":[{"key":"EntryName","value":"Ferritin"}]},{"database":"InterPro","id":"IPR012347","properties":[{"key":"EntryName","value":"Ferritin-like"}]},{"database":"InterPro","id":"IPR009040","properties":[{"key":"EntryName","value":"Ferritin-like_diiron"}]},{"database":"InterPro","id":"IPR009078","properties":[{"key":"EntryName","value":"Ferritin-like_SF"}]},{"database":"InterPro","id":"IPR008331","properties":[{"key":"EntryName","value":"Ferritin_DPS_dom"}]},{"database":"PANTHER","id":"PTHR11431","properties":[{"key":"EntryName","value":"FERRITIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11431:SF37","properties":[{"key":"EntryName","value":"FERRITIN HEAVY CHAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00210","properties":[{"key":"EntryName","value":"Ferritin"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF47240","properties":[{"key":"EntryName","value":"Ferritin-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50905","properties":[{"key":"EntryName","value":"FERRITIN_LIKE"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MKLQNQRGGRIFLQDIKKPDCDDWESGLNAMECALHLEKNVNQSLLELHKLATDKNDP","length":58,"molWeight":6664,"crc64":"A864B8CDCADB8E78","md5":"CBC9E97C9B478F848DB6AB4B29403004"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Domain":1,"Binding site":2,"Non-terminal residue":1},"uniParcId":"UPI0001F77B8C"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"E9PQR3","uniProtkbId":"E9PQR3_HUMAN","entryAudit":{"firstPublicDate":"2011-04-05","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-04-05","entryVersion":82,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000434403.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361145"}],"value":"Ferritin"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000434403.1"}],"value":"FTH1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361145"}],"value":"Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004419"}],"value":"Cytoplasmic vesicle, autophagosome","id":"SL-0023"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361145"}],"value":"Belongs to the ferritin family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00085"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Transmembrane","location":{"start":{"value":30,"modifier":"EXACT"},"end":{"value":49,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":11,"modifier":"EXACT"},"end":{"value":50,"modifier":"EXACT"}},"description":"Ferritin-like diiron","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50905"}]},{"type":"Binding site","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":28,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:24875"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601519-1"}],"ligand":{"name":"Fe cation","id":"ChEBI:CHEBI:24875","label":"1"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601519-1"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361145"}],"id":"KW-0408","category":"Ligand","name":"Iron"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361145"}],"id":"KW-0409","category":"Biological process","name":"Iron storage"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601519-1"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361145"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"E9PQR3"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"E9PQR3"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000434403.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000434403.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16554811","citationType":"journal article","authors":["Taylor T.D.","Noguchi H.","Totoki Y.","Toyoda A.","Kuroki Y.","Dewar K.","Lloyd C.","Itoh T.","Takeda T.","Kim D.W.","She X.","Barlow K.F.","Bloom T.","Bruford E.","Chang J.L.","Cuomo C.A.","Eichler E.","FitzGerald M.G.","Jaffe D.B.","LaButti K.","Nicol R.","Park H.S.","Seaman C.","Sougnez C.","Yang X.","Zimmer A.R.","Zody M.C.","Birren B.W.","Nusbaum C.","Fujiyama A.","Hattori M.","Rogers J.","Lander E.S.","Sakaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"16554811"},{"database":"DOI","id":"10.1038/nature04632"}],"title":"Human chromosome 11 DNA sequence and analysis including novel gene identification.","publicationDate":"2006","journal":"Nature","firstPage":"497","lastPage":"500","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000434403.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Burckstummer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"21269460"}]},{"referenceNumber":5,"citation":{"id":"22814378","citationType":"journal article","authors":["Van Damme P.","Lasa M.","Polevoda B.","Gazquez C.","Elosegui-Artola A.","Kim D.S.","De Juan-Pardo E.","Demeyer K.","Hole K.","Larrea E.","Timmerman E.","Prieto J.","Arnesen T.","Sherman F.","Gevaert K.","Aldabe R."],"citationCrossReferences":[{"database":"PubMed","id":"22814378"},{"database":"DOI","id":"10.1073/pnas.1210303109"}],"title":"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.","publicationDate":"2012","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"12449","lastPage":"12454","volume":"109"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"22814378"}]},{"referenceNumber":6,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000434403.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AP003733","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"E9PQR3","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"E9PQR3","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"E9PQR3","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"23093","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000534180.1","properties":[{"key":"ProteinId","value":"ENSP00000434403.1"},{"key":"GeneId","value":"ENSG00000167996.17"}]},{"database":"UCSC","id":"uc058cgp.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:3976","properties":[{"key":"GeneName","value":"FTH1"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000167996","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00950000182841","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_3124501_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"186462at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"FTH1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 11"}]},{"database":"Bgee","id":"ENSG00000167996","properties":[{"key":"ExpressionPatterns","value":"Expressed in stromal cell of endometrium and 198 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"E9PQR3","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005776","properties":[{"key":"GoTerm","value":"C:autophagosome"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0008199","properties":[{"key":"GoTerm","value":"F:ferric iron binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006879","properties":[{"key":"GoTerm","value":"P:intracellular iron ion homeostasis"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006826","properties":[{"key":"GoTerm","value":"P:iron ion transport"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"1.20.1260.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001519","properties":[{"key":"EntryName","value":"Ferritin"}]},{"database":"InterPro","id":"IPR012347","properties":[{"key":"EntryName","value":"Ferritin-like"}]},{"database":"InterPro","id":"IPR009040","properties":[{"key":"EntryName","value":"Ferritin-like_diiron"}]},{"database":"InterPro","id":"IPR009078","properties":[{"key":"EntryName","value":"Ferritin-like_SF"}]},{"database":"PANTHER","id":"PTHR11431","properties":[{"key":"EntryName","value":"FERRITIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11431:SF37","properties":[{"key":"EntryName","value":"FERRITIN HEAVY CHAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF47240","properties":[{"key":"EntryName","value":"Ferritin-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50905","properties":[{"key":"EntryName","value":"FERRITIN_LIKE"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MTTASTSQVRQNYHQDSEAAINRQINLELYASYVYLSMIVTATCLWGSLV","length":50,"molWeight":5642,"crc64":"F3098BCFCE24D9C8","md5":"E7CE150E5EC00C4D8EBEB77F60ADCBB8"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Transmembrane":1,"Domain":1,"Binding site":1},"uniParcId":"UPI0001F77B8B"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"E9PK45","uniProtkbId":"E9PK45_HUMAN","entryAudit":{"firstPublicDate":"2011-04-05","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-04-05","entryVersion":87,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000431659.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00039731"}],"value":"Ferritin heavy chain"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000431659.1"}],"value":"FTH1"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004419"}],"value":"Cytoplasmic vesicle, autophagosome","id":"SL-0023"}}]}],"features":[{"type":"Binding site","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":28,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:24875"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601519-1"}],"ligand":{"name":"Fe cation","id":"ChEBI:CHEBI:24875","label":"1"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601519-1"}],"id":"KW-0408","category":"Ligand","name":"Iron"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601519-1"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"E9PK45"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"E9PK45"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000431659.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000431659.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16554811","citationType":"journal article","authors":["Taylor T.D.","Noguchi H.","Totoki Y.","Toyoda A.","Kuroki Y.","Dewar K.","Lloyd C.","Itoh T.","Takeda T.","Kim D.W.","She X.","Barlow K.F.","Bloom T.","Bruford E.","Chang J.L.","Cuomo C.A.","Eichler E.","FitzGerald M.G.","Jaffe D.B.","LaButti K.","Nicol R.","Park H.S.","Seaman C.","Sougnez C.","Yang X.","Zimmer A.R.","Zody M.C.","Birren B.W.","Nusbaum C.","Fujiyama A.","Hattori M.","Rogers J.","Lander E.S.","Sakaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"16554811"},{"database":"DOI","id":"10.1038/nature04632"}],"title":"Human chromosome 11 DNA sequence and analysis including novel gene identification.","publicationDate":"2006","journal":"Nature","firstPage":"497","lastPage":"500","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000431659.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Burckstummer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"21269460"}]},{"referenceNumber":5,"citation":{"id":"22814378","citationType":"journal article","authors":["Van Damme P.","Lasa M.","Polevoda B.","Gazquez C.","Elosegui-Artola A.","Kim D.S.","De Juan-Pardo E.","Demeyer K.","Hole K.","Larrea E.","Timmerman E.","Prieto J.","Arnesen T.","Sherman F.","Gevaert K.","Aldabe R."],"citationCrossReferences":[{"database":"PubMed","id":"22814378"},{"database":"DOI","id":"10.1073/pnas.1210303109"}],"title":"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.","publicationDate":"2012","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"12449","lastPage":"12454","volume":"109"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"22814378"}]},{"referenceNumber":6,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000431659.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AP003733","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"E9PK45","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"E9PK45","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"E9PK45","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"21344","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"28385","properties":[{"key":"antibodies","value":"912 antibodies from 44 providers"}]},{"database":"Ensembl","id":"ENST00000529191.5","properties":[{"key":"ProteinId","value":"ENSP00000431659.1"},{"key":"GeneId","value":"ENSG00000167996.17"}]},{"database":"UCSC","id":"uc058cgk.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:3976","properties":[{"key":"GeneName","value":"FTH1"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000167996","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00950000182841","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_2276488_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"186462at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"FTH1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 11"}]},{"database":"Bgee","id":"ENSG00000167996","properties":[{"key":"ExpressionPatterns","value":"Expressed in stromal cell of endometrium and 198 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"E9PK45","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005776","properties":[{"key":"GoTerm","value":"C:autophagosome"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0008199","properties":[{"key":"GoTerm","value":"F:ferric iron binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006879","properties":[{"key":"GoTerm","value":"P:intracellular iron ion homeostasis"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006826","properties":[{"key":"GoTerm","value":"P:iron ion transport"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"1.20.1260.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001519","properties":[{"key":"EntryName","value":"Ferritin"}]},{"database":"InterPro","id":"IPR012347","properties":[{"key":"EntryName","value":"Ferritin-like"}]},{"database":"InterPro","id":"IPR009078","properties":[{"key":"EntryName","value":"Ferritin-like_SF"}]},{"database":"PANTHER","id":"PTHR11431","properties":[{"key":"EntryName","value":"FERRITIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11431:SF37","properties":[{"key":"EntryName","value":"FERRITIN HEAVY CHAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF47240","properties":[{"key":"EntryName","value":"Ferritin-like"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MTTASTSQVRQNYHQDSEAAINRQINLELYASYVYLSMVLVHLIHSQQGHLVTRDRRSPTERSSQAGPCMCLMTWRNLSLSLDLSFPACEMGRWVPACSLKD","length":102,"molWeight":11603,"crc64":"678662167E30DC9E","md5":"3501072B4C47B21F5A4C3A1AF16ED890"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Binding site":1},"uniParcId":"UPI0001F77B88"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"E9PKM5","uniProtkbId":"E9PKM5_HUMAN","entryAudit":{"firstPublicDate":"2011-04-05","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-04-05","entryVersion":83,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000431575.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00039731"}],"value":"Ferritin heavy chain"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000431575.1"}],"value":"FTH1"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004419"}],"value":"Cytoplasmic vesicle, autophagosome","id":"SL-0023"}}]}],"features":[{"type":"Binding site","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":28,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:24875"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601519-1"}],"ligand":{"name":"Fe cation","id":"ChEBI:CHEBI:24875","label":"1"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601519-1"}],"id":"KW-0408","category":"Ligand","name":"Iron"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601519-1"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"E9PKM5"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"E9PKM5"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000431575.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000431575.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16554811","citationType":"journal article","authors":["Taylor T.D.","Noguchi H.","Totoki Y.","Toyoda A.","Kuroki Y.","Dewar K.","Lloyd C.","Itoh T.","Takeda T.","Kim D.W.","She X.","Barlow K.F.","Bloom T.","Bruford E.","Chang J.L.","Cuomo C.A.","Eichler E.","FitzGerald M.G.","Jaffe D.B.","LaButti K.","Nicol R.","Park H.S.","Seaman C.","Sougnez C.","Yang X.","Zimmer A.R.","Zody M.C.","Birren B.W.","Nusbaum C.","Fujiyama A.","Hattori M.","Rogers J.","Lander E.S.","Sakaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"16554811"},{"database":"DOI","id":"10.1038/nature04632"}],"title":"Human chromosome 11 DNA sequence and analysis including novel gene identification.","publicationDate":"2006","journal":"Nature","firstPage":"497","lastPage":"500","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000431575.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Burckstummer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"21269460"}]},{"referenceNumber":5,"citation":{"id":"22814378","citationType":"journal article","authors":["Van Damme P.","Lasa M.","Polevoda B.","Gazquez C.","Elosegui-Artola A.","Kim D.S.","De Juan-Pardo E.","Demeyer K.","Hole K.","Larrea E.","Timmerman E.","Prieto J.","Arnesen T.","Sherman F.","Gevaert K.","Aldabe R."],"citationCrossReferences":[{"database":"PubMed","id":"22814378"},{"database":"DOI","id":"10.1073/pnas.1210303109"}],"title":"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.","publicationDate":"2012","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"12449","lastPage":"12454","volume":"109"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"22814378"}]},{"referenceNumber":6,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000431575.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AP003733","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"E9PKM5","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"E9PKM5","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"E9PKM5","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"21517","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"28385","properties":[{"key":"antibodies","value":"912 antibodies from 44 providers"}]},{"database":"Ensembl","id":"ENST00000529631.5","properties":[{"key":"ProteinId","value":"ENSP00000431575.1"},{"key":"GeneId","value":"ENSG00000167996.17"}]},{"database":"UCSC","id":"uc058cgl.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:3976","properties":[{"key":"GeneName","value":"FTH1"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000167996","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00950000182841","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_2573223_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"186462at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"FTH1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 11"}]},{"database":"Bgee","id":"ENSG00000167996","properties":[{"key":"ExpressionPatterns","value":"Expressed in stromal cell of endometrium and 198 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"E9PKM5","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005776","properties":[{"key":"GoTerm","value":"C:autophagosome"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0008199","properties":[{"key":"GoTerm","value":"F:ferric iron binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006879","properties":[{"key":"GoTerm","value":"P:intracellular iron ion homeostasis"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006826","properties":[{"key":"GoTerm","value":"P:iron ion transport"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"1.20.1260.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001519","properties":[{"key":"EntryName","value":"Ferritin"}]},{"database":"InterPro","id":"IPR012347","properties":[{"key":"EntryName","value":"Ferritin-like"}]},{"database":"InterPro","id":"IPR009078","properties":[{"key":"EntryName","value":"Ferritin-like_SF"}]},{"database":"PANTHER","id":"PTHR11431","properties":[{"key":"EntryName","value":"FERRITIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11431:SF37","properties":[{"key":"EntryName","value":"FERRITIN HEAVY CHAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF47240","properties":[{"key":"EntryName","value":"Ferritin-like"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MTTASTSQVRQNYHQDSEAAINRQINLELYASYVYLSMPTGTPGHQGQKKSHRKIIPGRTLYVPDDLEESLPLSGPQFPCL","length":81,"molWeight":9076,"crc64":"D61F968A2D47F4A3","md5":"B70B26E056E6FD3356DCFBCDAFEA2D79"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Binding site":1},"uniParcId":"UPI0001F77B89"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8RSQ0","uniProtkbId":"A0ACI8RSQ0_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000567124.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361145"}],"value":"Ferritin"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000567124.1"}],"value":"FTH1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361145"}],"value":"Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:11148"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:15379"},{"database":"ChEBI","id":"CHEBI:29033"},{"database":"ChEBI","id":"CHEBI:29034"}],"ecNumber":"1.16.3.1","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047990"}]}},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004419"}],"value":"Cytoplasmic vesicle, autophagosome","id":"SL-0023"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004371"}],"value":"Lysosome","id":"SL-0158"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007513"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361145"}],"value":"Belongs to the ferritin family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00085"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Domain","location":{"start":{"value":11,"modifier":"EXACT"},"end":{"value":141,"modifier":"EXACT"}},"description":"Ferritin-like diiron","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50905"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023329"}],"id":"KW-0968","category":"Cellular component","name":"Cytoplasmic vesicle"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023004"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361145"}],"id":"KW-0408","category":"Ligand","name":"Iron"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022434"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361145"}],"id":"KW-0409","category":"Biological process","name":"Iron storage"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023228"}],"id":"KW-0458","category":"Cellular component","name":"Lysosome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361145"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023002"}],"id":"KW-0560","category":"Molecular function","name":"Oxidoreductase"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8RSQ0"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8RSQ0"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000567124.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000567124.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16554811","citationType":"journal article","authors":["Taylor T.D.","Noguchi H.","Totoki Y.","Toyoda A.","Kuroki Y.","Dewar K.","Lloyd C.","Itoh T.","Takeda T.","Kim D.W.","She X.","Barlow K.F.","Bloom T.","Bruford E.","Chang J.L.","Cuomo C.A.","Eichler E.","FitzGerald M.G.","Jaffe D.B.","LaButti K.","Nicol R.","Park H.S.","Seaman C.","Sougnez C.","Yang X.","Zimmer A.R.","Zody M.C.","Birren B.W.","Nusbaum C.","Fujiyama A.","Hattori M.","Rogers J.","Lander E.S.","Sakaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"16554811"},{"database":"DOI","id":"10.1038/nature04632"}],"title":"Human chromosome 11 DNA sequence and analysis including novel gene identification.","publicationDate":"2006","journal":"Nature","firstPage":"497","lastPage":"500","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000567124.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000567124.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AP003733","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000897065.1","properties":[{"key":"ProteinId","value":"ENSP00000567124.1"},{"key":"GeneId","value":"ENSG00000167996.17"}]},{"database":"HGNC","id":"HGNC:3976","properties":[{"key":"GeneName","value":"FTH1"}]},{"database":"OpenTargets","id":"ENSG00000167996","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00950000182841","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 11"}]},{"database":"CDD","id":"cd01056","properties":[{"key":"EntryName","value":"Euk_Ferritin"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.1260.10:FF:000024","properties":[{"key":"EntryName","value":"Ferritin heavy chain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1260.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR001519","properties":[{"key":"EntryName","value":"Ferritin"}]},{"database":"InterPro","id":"IPR012347","properties":[{"key":"EntryName","value":"Ferritin-like"}]},{"database":"InterPro","id":"IPR009040","properties":[{"key":"EntryName","value":"Ferritin-like_diiron"}]},{"database":"InterPro","id":"IPR009078","properties":[{"key":"EntryName","value":"Ferritin-like_SF"}]},{"database":"InterPro","id":"IPR014034","properties":[{"key":"EntryName","value":"Ferritin_CS"}]},{"database":"InterPro","id":"IPR008331","properties":[{"key":"EntryName","value":"Ferritin_DPS_dom"}]},{"database":"PANTHER","id":"PTHR11431","properties":[{"key":"EntryName","value":"FERRITIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11431:SF37","properties":[{"key":"EntryName","value":"FERRITIN HEAVY CHAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00210","properties":[{"key":"EntryName","value":"Ferritin"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF47240","properties":[{"key":"EntryName","value":"Ferritin-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00540","properties":[{"key":"EntryName","value":"FERRITIN_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00204","properties":[{"key":"EntryName","value":"FERRITIN_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50905","properties":[{"key":"EntryName","value":"FERRITIN_LIKE"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MTTASTSQVRQNYHQDSEAAINRQINLELYASYVYLSMSYYFDRDDVALKNFAKYFLHQSHEEREHAEKLMKLQNQRGGRIFLQDIKLCDFIETHYLNEQVKAIKELGDHVTNLRKMGAPESGLAEYLFDKHTLGDSDNES","length":141,"molWeight":16470,"crc64":"B993A763E43229ED","md5":"502CB0DE6E645B5DC2FC26775178599A"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Domain":1},"uniParcId":"UPI004031E456"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8SCA2","uniProtkbId":"A0ACI8SCA2_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000567123.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361145"}],"value":"Ferritin"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000567123.1"}],"value":"FTH1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361145"}],"value":"Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:11148"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:15379"},{"database":"ChEBI","id":"CHEBI:29033"},{"database":"ChEBI","id":"CHEBI:29034"}],"ecNumber":"1.16.3.1","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047990"}]}},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004419"}],"value":"Cytoplasmic vesicle, autophagosome","id":"SL-0023"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007513"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361145"}],"value":"Belongs to the ferritin family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":111,"modifier":"EXACT"}},"description":"Ferritin-like diiron","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50905"}]},{"type":"Binding site","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"axial binding residue","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:60344"},{"database":"ChEBI","id":"CHEBI:18248"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00085"}],"ligand":{"name":"heme b","id":"ChEBI:CHEBI:60344"},"ligandPart":{"name":"Fe","id":"ChEBI:CHEBI:18248"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023004"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00085"}],"id":"KW-0408","category":"Ligand","name":"Iron"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022434"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361145"}],"id":"KW-0409","category":"Biological process","name":"Iron storage"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00085"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023002"}],"id":"KW-0560","category":"Molecular function","name":"Oxidoreductase"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8SCA2"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8SCA2"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000567123.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000567123.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16554811","citationType":"journal article","authors":["Taylor T.D.","Noguchi H.","Totoki Y.","Toyoda A.","Kuroki Y.","Dewar K.","Lloyd C.","Itoh T.","Takeda T.","Kim D.W.","She X.","Barlow K.F.","Bloom T.","Bruford E.","Chang J.L.","Cuomo C.A.","Eichler E.","FitzGerald M.G.","Jaffe D.B.","LaButti K.","Nicol R.","Park H.S.","Seaman C.","Sougnez C.","Yang X.","Zimmer A.R.","Zody M.C.","Birren B.W.","Nusbaum C.","Fujiyama A.","Hattori M.","Rogers J.","Lander E.S.","Sakaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"16554811"},{"database":"DOI","id":"10.1038/nature04632"}],"title":"Human chromosome 11 DNA sequence and analysis including novel gene identification.","publicationDate":"2006","journal":"Nature","firstPage":"497","lastPage":"500","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000567123.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000567123.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AP003733","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000897064.1","properties":[{"key":"ProteinId","value":"ENSP00000567123.1"},{"key":"GeneId","value":"ENSG00000167996.17"}]},{"database":"HGNC","id":"HGNC:3976","properties":[{"key":"GeneName","value":"FTH1"}]},{"database":"OpenTargets","id":"ENSG00000167996","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00950000182841","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 11"}]},{"database":"CDD","id":"cd01056","properties":[{"key":"EntryName","value":"Euk_Ferritin"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.1260.10:FF:000016","properties":[{"key":"EntryName","value":"Ferritin heavy chain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1260.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR001519","properties":[{"key":"EntryName","value":"Ferritin"}]},{"database":"InterPro","id":"IPR012347","properties":[{"key":"EntryName","value":"Ferritin-like"}]},{"database":"InterPro","id":"IPR009040","properties":[{"key":"EntryName","value":"Ferritin-like_diiron"}]},{"database":"InterPro","id":"IPR009078","properties":[{"key":"EntryName","value":"Ferritin-like_SF"}]},{"database":"InterPro","id":"IPR014034","properties":[{"key":"EntryName","value":"Ferritin_CS"}]},{"database":"InterPro","id":"IPR008331","properties":[{"key":"EntryName","value":"Ferritin_DPS_dom"}]},{"database":"PANTHER","id":"PTHR11431","properties":[{"key":"EntryName","value":"FERRITIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11431:SF37","properties":[{"key":"EntryName","value":"FERRITIN HEAVY CHAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00210","properties":[{"key":"EntryName","value":"Ferritin"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF47240","properties":[{"key":"EntryName","value":"Ferritin-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00204","properties":[{"key":"EntryName","value":"FERRITIN_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50905","properties":[{"key":"EntryName","value":"FERRITIN_LIKE"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MTTASTSQVRQNYHQDSEAAINRQINLELYASYVYLSMKPDCDDWESGLNAMECALHLEKNVNQSLLELHKLATDKNDPHLCDFIETHYLNEQVKAIKELGDHVTNLRKMGAPESGLAEYLFDKHTLGDSDNES","length":134,"molWeight":15229,"crc64":"7F21BC30CE52A6D7","md5":"50E89FC8BDD99FA733710976DF622F9E"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Domain":1,"Binding site":1},"uniParcId":"UPI004031E526"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8R4N0","uniProtkbId":"A0ACI8R4N0_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000567125.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361145"}],"value":"Ferritin"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000567125.1"}],"value":"FTH1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361145"}],"value":"Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:11148"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:15379"},{"database":"ChEBI","id":"CHEBI:29033"},{"database":"ChEBI","id":"CHEBI:29034"}],"ecNumber":"1.16.3.1","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047990"}]}},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004419"}],"value":"Cytoplasmic vesicle, autophagosome","id":"SL-0023"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004371"}],"value":"Lysosome","id":"SL-0158"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007513"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361145"}],"value":"Belongs to the ferritin family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00085"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Domain","location":{"start":{"value":11,"modifier":"EXACT"},"end":{"value":157,"modifier":"EXACT"}},"description":"Ferritin-like diiron","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50905"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023329"}],"id":"KW-0968","category":"Cellular component","name":"Cytoplasmic vesicle"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023004"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361145"}],"id":"KW-0408","category":"Ligand","name":"Iron"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022434"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361145"}],"id":"KW-0409","category":"Biological process","name":"Iron storage"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023228"}],"id":"KW-0458","category":"Cellular component","name":"Lysosome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361145"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023002"}],"id":"KW-0560","category":"Molecular function","name":"Oxidoreductase"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8R4N0"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8R4N0"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000567125.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000567125.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16554811","citationType":"journal article","authors":["Taylor T.D.","Noguchi H.","Totoki Y.","Toyoda A.","Kuroki Y.","Dewar K.","Lloyd C.","Itoh T.","Takeda T.","Kim D.W.","She X.","Barlow K.F.","Bloom T.","Bruford E.","Chang J.L.","Cuomo C.A.","Eichler E.","FitzGerald M.G.","Jaffe D.B.","LaButti K.","Nicol R.","Park H.S.","Seaman C.","Sougnez C.","Yang X.","Zimmer A.R.","Zody M.C.","Birren B.W.","Nusbaum C.","Fujiyama A.","Hattori M.","Rogers J.","Lander E.S.","Sakaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"16554811"},{"database":"DOI","id":"10.1038/nature04632"}],"title":"Human chromosome 11 DNA sequence and analysis including novel gene identification.","publicationDate":"2006","journal":"Nature","firstPage":"497","lastPage":"500","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000567125.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000567125.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AP003733","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000897066.1","properties":[{"key":"ProteinId","value":"ENSP00000567125.1"},{"key":"GeneId","value":"ENSG00000167996.17"}]},{"database":"HGNC","id":"HGNC:3976","properties":[{"key":"GeneName","value":"FTH1"}]},{"database":"OpenTargets","id":"ENSG00000167996","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00950000182841","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 11"}]},{"database":"CDD","id":"cd01056","properties":[{"key":"EntryName","value":"Euk_Ferritin"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.1260.10:FF:000024","properties":[{"key":"EntryName","value":"Ferritin heavy chain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1260.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001519","properties":[{"key":"EntryName","value":"Ferritin"}]},{"database":"InterPro","id":"IPR012347","properties":[{"key":"EntryName","value":"Ferritin-like"}]},{"database":"InterPro","id":"IPR009040","properties":[{"key":"EntryName","value":"Ferritin-like_diiron"}]},{"database":"InterPro","id":"IPR009078","properties":[{"key":"EntryName","value":"Ferritin-like_SF"}]},{"database":"InterPro","id":"IPR014034","properties":[{"key":"EntryName","value":"Ferritin_CS"}]},{"database":"InterPro","id":"IPR008331","properties":[{"key":"EntryName","value":"Ferritin_DPS_dom"}]},{"database":"PANTHER","id":"PTHR11431","properties":[{"key":"EntryName","value":"FERRITIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11431:SF37","properties":[{"key":"EntryName","value":"FERRITIN HEAVY CHAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00210","properties":[{"key":"EntryName","value":"Ferritin"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF47240","properties":[{"key":"EntryName","value":"Ferritin-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00540","properties":[{"key":"EntryName","value":"FERRITIN_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50905","properties":[{"key":"EntryName","value":"FERRITIN_LIKE"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MTTASTSQVRQNYHQDSEAAINRQINLELYASYVYLSMSYYFDRDDVALKNFAKYFLHQSHEEREHAEKLMKLQNQRGGRIFLQDIKKPDCDDWESGLNAMECALHLEKNVNQSLLELHKLATDKNDPHVKAIKELGDHVTNLRKMGAPESGLAEYLFDKHTLGDSDNES","length":170,"molWeight":19619,"crc64":"EDBAA8B228B40A5F","md5":"C700F8F6456B65C6ED7106A1F229C49F"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Domain":1},"uniParcId":"UPI004031C688"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"E9PRK8","uniProtkbId":"E9PRK8_HUMAN","entryAudit":{"firstPublicDate":"2011-04-05","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-04-05","entryVersion":89,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000432223.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361145"}],"value":"Ferritin"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000432223.1"}],"value":"FTH1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361145"}],"value":"Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:11148"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:15379"},{"database":"ChEBI","id":"CHEBI:29033"},{"database":"ChEBI","id":"CHEBI:29034"}],"ecNumber":"1.16.3.1","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047990"}]}},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004419"}],"value":"Cytoplasmic vesicle, autophagosome","id":"SL-0023"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004371"}],"value":"Lysosome","id":"SL-0158"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007513"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361145"}],"value":"Belongs to the ferritin family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00085"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Domain","location":{"start":{"value":11,"modifier":"EXACT"},"end":{"value":95,"modifier":"EXACT"}},"description":"Ferritin-like diiron","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50905"}]},{"type":"Binding site","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":28,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:24875"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601519-1"}],"ligand":{"name":"Fe cation","id":"ChEBI:CHEBI:24875","label":"1"}},{"type":"Binding site","location":{"start":{"value":63,"modifier":"EXACT"},"end":{"value":63,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:24875"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601519-1"}],"ligand":{"name":"Fe cation","id":"ChEBI:CHEBI:24875","label":"1"}},{"type":"Binding site","location":{"start":{"value":66,"modifier":"EXACT"},"end":{"value":66,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:24875"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601519-1"}],"ligand":{"name":"Fe cation","id":"ChEBI:CHEBI:24875","label":"1"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023329"}],"id":"KW-0968","category":"Cellular component","name":"Cytoplasmic vesicle"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023004"},{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601519-1"}],"id":"KW-0408","category":"Ligand","name":"Iron"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022434"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361145"}],"id":"KW-0409","category":"Biological process","name":"Iron storage"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023228"}],"id":"KW-0458","category":"Cellular component","name":"Lysosome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"},{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601519-1"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023002"}],"id":"KW-0560","category":"Molecular function","name":"Oxidoreductase"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"E9PRK8"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"E9PRK8"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000432223.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000432223.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16554811","citationType":"journal article","authors":["Taylor T.D.","Noguchi H.","Totoki Y.","Toyoda A.","Kuroki Y.","Dewar K.","Lloyd C.","Itoh T.","Takeda T.","Kim D.W.","She X.","Barlow K.F.","Bloom T.","Bruford E.","Chang J.L.","Cuomo C.A.","Eichler E.","FitzGerald M.G.","Jaffe D.B.","LaButti K.","Nicol R.","Park H.S.","Seaman C.","Sougnez C.","Yang X.","Zimmer A.R.","Zody M.C.","Birren B.W.","Nusbaum C.","Fujiyama A.","Hattori M.","Rogers J.","Lander E.S.","Sakaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"16554811"},{"database":"DOI","id":"10.1038/nature04632"}],"title":"Human chromosome 11 DNA sequence and analysis including novel gene identification.","publicationDate":"2006","journal":"Nature","firstPage":"497","lastPage":"500","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000432223.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Burckstummer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"21269460"}]},{"referenceNumber":5,"citation":{"id":"22814378","citationType":"journal article","authors":["Van Damme P.","Lasa M.","Polevoda B.","Gazquez C.","Elosegui-Artola A.","Kim D.S.","De Juan-Pardo E.","Demeyer K.","Hole K.","Larrea E.","Timmerman E.","Prieto J.","Arnesen T.","Sherman F.","Gevaert K.","Aldabe R."],"citationCrossReferences":[{"database":"PubMed","id":"22814378"},{"database":"DOI","id":"10.1073/pnas.1210303109"}],"title":"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.","publicationDate":"2012","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"12449","lastPage":"12454","volume":"109"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"22814378"}]},{"referenceNumber":6,"citation":{"id":"25944712","citationType":"journal article","authors":["Vaca Jacome A.S.","Rabilloud T.","Schaeffer-Reiss C.","Rompais M.","Ayoub D.","Lane L.","Bairoch A.","Van Dorsselaer A.","Carapito C."],"citationCrossReferences":[{"database":"PubMed","id":"25944712"}],"title":"N-terminome analysis of the human mitochondrial proteome.","publicationDate":"2015","journal":"Proteomics","firstPage":"2519","lastPage":"2524","volume":"15"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"25944712"}]},{"referenceNumber":7,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000432223.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AP003733","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"E9PRK8","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"E9PRK8","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"E9PRK8","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"23344","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000532829.5","properties":[{"key":"ProteinId","value":"ENSP00000432223.1"},{"key":"GeneId","value":"ENSG00000167996.17"}]},{"database":"UCSC","id":"uc058cgn.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:3976","properties":[{"key":"GeneName","value":"FTH1"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000167996","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00950000182841","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_065681_5_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"186462at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"FTH1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 11"}]},{"database":"Bgee","id":"ENSG00000167996","properties":[{"key":"ExpressionPatterns","value":"Expressed in stromal cell of endometrium and 198 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"E9PRK8","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005776","properties":[{"key":"GoTerm","value":"C:autophagosome"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005764","properties":[{"key":"GoTerm","value":"C:lysosome"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0008199","properties":[{"key":"GoTerm","value":"F:ferric iron binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0004322","properties":[{"key":"GoTerm","value":"F:ferroxidase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0006879","properties":[{"key":"GoTerm","value":"P:intracellular iron ion homeostasis"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006826","properties":[{"key":"GoTerm","value":"P:iron ion transport"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd01056","properties":[{"key":"EntryName","value":"Euk_Ferritin"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.1260.10:FF:000024","properties":[{"key":"EntryName","value":"Ferritin heavy chain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1260.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001519","properties":[{"key":"EntryName","value":"Ferritin"}]},{"database":"InterPro","id":"IPR012347","properties":[{"key":"EntryName","value":"Ferritin-like"}]},{"database":"InterPro","id":"IPR009040","properties":[{"key":"EntryName","value":"Ferritin-like_diiron"}]},{"database":"InterPro","id":"IPR009078","properties":[{"key":"EntryName","value":"Ferritin-like_SF"}]},{"database":"InterPro","id":"IPR014034","properties":[{"key":"EntryName","value":"Ferritin_CS"}]},{"database":"InterPro","id":"IPR008331","properties":[{"key":"EntryName","value":"Ferritin_DPS_dom"}]},{"database":"PANTHER","id":"PTHR11431","properties":[{"key":"EntryName","value":"FERRITIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11431:SF37","properties":[{"key":"EntryName","value":"FERRITIN HEAVY CHAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00210","properties":[{"key":"EntryName","value":"Ferritin"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF47240","properties":[{"key":"EntryName","value":"Ferritin-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00540","properties":[{"key":"EntryName","value":"FERRITIN_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50905","properties":[{"key":"EntryName","value":"FERRITIN_LIKE"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MTTASTSQVRQNYHQDSEAAINRQINLELYASYVYLSMSYYFDRDDVALKNFAKYFLHQSHEEREHAEKLMKLQNQRGGRIFLQDIKTVMTGRAG","length":95,"molWeight":11169,"crc64":"7999ADC179A7EF1D","md5":"EE90D7F59FEA03161C2C0F3C0D29B81F"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Domain":1,"Binding site":3},"uniParcId":"UPI00001FA8F3"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"G3V1D1","uniProtkbId":"G3V1D1_HUMAN","entryAudit":{"firstPublicDate":"2011-11-16","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-11-16","entryVersion":119,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000435111.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361145"}],"value":"Ferritin"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000435111.1"}],"value":"FTH1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361145"}],"value":"Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:11148"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:15379"},{"database":"ChEBI","id":"CHEBI:29033"},{"database":"ChEBI","id":"CHEBI:29034"}],"ecNumber":"1.16.3.1","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047990"}]}},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004419"}],"value":"Cytoplasmic vesicle, autophagosome","id":"SL-0023"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007513"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361145"}],"value":"Belongs to the ferritin family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":90,"modifier":"EXACT"}},"description":"Ferritin-like diiron","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50905"}]},{"type":"Binding site","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"axial binding residue","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:60344"},{"database":"ChEBI","id":"CHEBI:18248"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00085"}],"ligand":{"name":"heme b","id":"ChEBI:CHEBI:60344"},"ligandPart":{"name":"Fe","id":"ChEBI:CHEBI:18248"}},{"type":"Binding site","location":{"start":{"value":38,"modifier":"EXACT"},"end":{"value":38,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:24875"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601519-1"}],"ligand":{"name":"Fe cation","id":"ChEBI:CHEBI:24875","label":"1"}},{"type":"Binding site","location":{"start":{"value":72,"modifier":"EXACT"},"end":{"value":72,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:24875"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601519-1"}],"ligand":{"name":"Fe cation","id":"ChEBI:CHEBI:24875","label":"1"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023004"},{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601519-1"}],"id":"KW-0408","category":"Ligand","name":"Iron"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022434"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361145"}],"id":"KW-0409","category":"Biological process","name":"Iron storage"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"},{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601519-1"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023002"}],"id":"KW-0560","category":"Molecular function","name":"Oxidoreductase"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"G3V1D1"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"G3V1D1"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000435111.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000435111.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"17081983","citationType":"journal article","authors":["Olsen J.V.","Blagoev B.","Gnad F.","Macek B.","Kumar C.","Mortensen P.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"17081983"},{"database":"DOI","id":"10.1016/j.cell.2006.09.026"}],"title":"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.","publicationDate":"2006","journal":"Cell","firstPage":"635","lastPage":"648","volume":"127"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"17081983"}]},{"referenceNumber":4,"citation":{"id":"16554811","citationType":"journal article","authors":["Taylor T.D.","Noguchi H.","Totoki Y.","Toyoda A.","Kuroki Y.","Dewar K.","Lloyd C.","Itoh T.","Takeda T.","Kim D.W.","She X.","Barlow K.F.","Bloom T.","Bruford E.","Chang J.L.","Cuomo C.A.","Eichler E.","FitzGerald M.G.","Jaffe D.B.","LaButti K.","Nicol R.","Park H.S.","Seaman C.","Sougnez C.","Yang X.","Zimmer A.R.","Zody M.C.","Birren B.W.","Nusbaum C.","Fujiyama A.","Hattori M.","Rogers J.","Lander E.S.","Sakaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"16554811"},{"database":"DOI","id":"10.1038/nature04632"}],"title":"Human chromosome 11 DNA sequence and analysis including novel gene identification.","publicationDate":"2006","journal":"Nature","firstPage":"497","lastPage":"500","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000435111.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":5,"citation":{"id":"18669648","citationType":"journal article","authors":["Dephoure N.","Zhou C.","Villen J.","Beausoleil S.A.","Bakalarski C.E.","Elledge S.J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"18669648"},{"database":"DOI","id":"10.1073/pnas.0805139105"}],"title":"A quantitative atlas of mitotic phosphorylation.","publicationDate":"2008","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10762","lastPage":"10767","volume":"105"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"18669648"}]},{"referenceNumber":6,"citation":{"id":"18318008","citationType":"journal article","authors":["Han G.","Ye M.","Zhou H.","Jiang X.","Feng S.","Jiang X.","Tian R.","Wan D.","Zou H.","Gu J."],"citationCrossReferences":[{"database":"PubMed","id":"18318008"},{"database":"DOI","id":"10.1002/pmic.200700884"}],"title":"Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.","publicationDate":"2008","journal":"Proteomics","firstPage":"1346","lastPage":"1361","volume":"8"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"18318008"}]},{"referenceNumber":7,"citation":{"id":"20068231","citationType":"journal article","authors":["Olsen J.V.","Vermeulen M.","Santamaria A.","Kumar C.","Miller M.L.","Jensen L.J.","Gnad F.","Cox J.","Jensen T.S.","Nigg E.A.","Brunak S.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"20068231"},{"database":"DOI","id":"10.1126/scisignal.2000475"}],"title":"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.","publicationDate":"2010","journal":"Sci. Signal.","firstPage":"RA3","lastPage":"RA3","volume":"3"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"20068231"}]},{"referenceNumber":8,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Burckstummer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"21269460"}]},{"referenceNumber":9,"citation":{"id":"21406692","citationType":"journal article","authors":["Rigbolt K.T.","Prokhorova T.A.","Akimov V.","Henningsen J.","Johansen P.T.","Kratchmarova I.","Kassem M.","Mann M.","Olsen J.V.","Blagoev B."],"citationCrossReferences":[{"database":"PubMed","id":"21406692"},{"database":"DOI","id":"10.1126/scisignal.2001570"}],"title":"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.","publicationDate":"2011","journal":"Sci. Signal.","firstPage":"RS3","lastPage":"RS3","volume":"4"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"21406692"}]},{"referenceNumber":10,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"24275569"}]},{"referenceNumber":11,"citation":{"id":"25944712","citationType":"journal article","authors":["Vaca Jacome A.S.","Rabilloud T.","Schaeffer-Reiss C.","Rompais M.","Ayoub D.","Lane L.","Bairoch A.","Van Dorsselaer A.","Carapito C."],"citationCrossReferences":[{"database":"PubMed","id":"25944712"}],"title":"N-terminome analysis of the human mitochondrial proteome.","publicationDate":"2015","journal":"Proteomics","firstPage":"2519","lastPage":"2524","volume":"15"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"25944712"}]},{"referenceNumber":12,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000435111.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AP003733","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"G3V1D1","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"G3V1D1","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"32331","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"28385","properties":[{"key":"antibodies","value":"912 antibodies from 44 providers"}]},{"database":"Ensembl","id":"ENST00000532601.1","properties":[{"key":"ProteinId","value":"ENSP00000435111.1"},{"key":"GeneId","value":"ENSG00000167996.17"}]},{"database":"UCSC","id":"uc058cgr.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:3976","properties":[{"key":"GeneName","value":"FTH1"}]},{"database":"OpenTargets","id":"ENSG00000167996","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000167996","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00950000182841","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_065681_7_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"FFLKASM","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"186462at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"FTH1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 11"}]},{"database":"Bgee","id":"ENSG00000167996","properties":[{"key":"ExpressionPatterns","value":"Expressed in stromal cell of endometrium and 198 other cell types or tissues"}]},{"database":"GO","id":"GO:0005776","properties":[{"key":"GoTerm","value":"C:autophagosome"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0008199","properties":[{"key":"GoTerm","value":"F:ferric iron binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0004322","properties":[{"key":"GoTerm","value":"F:ferroxidase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0006879","properties":[{"key":"GoTerm","value":"P:intracellular iron ion homeostasis"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006826","properties":[{"key":"GoTerm","value":"P:iron ion transport"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd01056","properties":[{"key":"EntryName","value":"Euk_Ferritin"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.1260.10:FF:000016","properties":[{"key":"EntryName","value":"Ferritin heavy chain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1260.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001519","properties":[{"key":"EntryName","value":"Ferritin"}]},{"database":"InterPro","id":"IPR012347","properties":[{"key":"EntryName","value":"Ferritin-like"}]},{"database":"InterPro","id":"IPR009040","properties":[{"key":"EntryName","value":"Ferritin-like_diiron"}]},{"database":"InterPro","id":"IPR009078","properties":[{"key":"EntryName","value":"Ferritin-like_SF"}]},{"database":"InterPro","id":"IPR014034","properties":[{"key":"EntryName","value":"Ferritin_CS"}]},{"database":"InterPro","id":"IPR008331","properties":[{"key":"EntryName","value":"Ferritin_DPS_dom"}]},{"database":"PANTHER","id":"PTHR11431","properties":[{"key":"EntryName","value":"FERRITIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11431:SF37","properties":[{"key":"EntryName","value":"FERRITIN HEAVY CHAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00210","properties":[{"key":"EntryName","value":"Ferritin"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF47240","properties":[{"key":"EntryName","value":"Ferritin-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00204","properties":[{"key":"EntryName","value":"FERRITIN_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50905","properties":[{"key":"EntryName","value":"FERRITIN_LIKE"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MKLQNQRGGRIFLQDIKKPDCDDWESGLNAMECALHLEKNVNQSLLELHKLATDKNDPHLCDFIETHYLNEQVKAIKELGDHVTNLRKMGAPESGLAEYLFDKHTLGDSDNES","length":113,"molWeight":12876,"crc64":"A69F67B9F1A352AE","md5":"F96861D2E4B8FD4A1D81781CFC61E74E"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Domain":1,"Binding site":3},"uniParcId":"UPI0000EE4590"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8RY10","uniProtkbId":"A0ACI8RY10_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000567126.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00039731"}],"value":"Ferritin heavy chain"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000567126.1"}],"value":"FTH1"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004419"}],"value":"Cytoplasmic vesicle, autophagosome","id":"SL-0023"}}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8RY10"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8RY10"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000567126.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000567126.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16554811","citationType":"journal article","authors":["Taylor T.D.","Noguchi H.","Totoki Y.","Toyoda A.","Kuroki Y.","Dewar K.","Lloyd C.","Itoh T.","Takeda T.","Kim D.W.","She X.","Barlow K.F.","Bloom T.","Bruford E.","Chang J.L.","Cuomo C.A.","Eichler E.","FitzGerald M.G.","Jaffe D.B.","LaButti K.","Nicol R.","Park H.S.","Seaman C.","Sougnez C.","Yang X.","Zimmer A.R.","Zody M.C.","Birren B.W.","Nusbaum C.","Fujiyama A.","Hattori M.","Rogers J.","Lander E.S.","Sakaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"16554811"},{"database":"DOI","id":"10.1038/nature04632"}],"title":"Human chromosome 11 DNA sequence and analysis including novel gene identification.","publicationDate":"2006","journal":"Nature","firstPage":"497","lastPage":"500","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000567126.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000567126.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AP003733","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000897067.1","properties":[{"key":"ProteinId","value":"ENSP00000567126.1"},{"key":"GeneId","value":"ENSG00000167996.17"}]},{"database":"HGNC","id":"HGNC:3976","properties":[{"key":"GeneName","value":"FTH1"}]},{"database":"OpenTargets","id":"ENSG00000167996","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00950000182841","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 11"}]},{"database":"Gene3D","id":"1.20.1260.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR001519","properties":[{"key":"EntryName","value":"Ferritin"}]},{"database":"InterPro","id":"IPR012347","properties":[{"key":"EntryName","value":"Ferritin-like"}]},{"database":"InterPro","id":"IPR009078","properties":[{"key":"EntryName","value":"Ferritin-like_SF"}]},{"database":"PANTHER","id":"PTHR11431","properties":[{"key":"EntryName","value":"FERRITIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11431:SF37","properties":[{"key":"EntryName","value":"FERRITIN HEAVY CHAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF47240","properties":[{"key":"EntryName","value":"Ferritin-like"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MTTASTSQVRQNYHQDSEAAINRQINLELYASYVYLSMLCDFIETHYLNEQVKAIKELGDHVTNLRKMGAPESGLAEYLFDKHTLGDSDNES","length":92,"molWeight":10474,"crc64":"BBC91CAAA36A332C","md5":"3F94BA5D170ED44AC0DB9A4FAC01E3C7"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1},"uniParcId":"UPI004031C966"}}]}