{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P21462","secondaryAccessions":["Q14939","Q7Z6A4","Q86U52","Q9NS48"],"uniProtkbId":"FPR1_HUMAN","entryAudit":{"firstPublicDate":"1991-05-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2010-02-09","entryVersion":226,"sequenceVersion":3},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"N-formyl peptide receptor 1"}},"alternativeNames":[{"fullName":{"value":"N-formylpeptide chemoattractant receptor"}},{"fullName":{"value":"fMet-Leu-Phe receptor"},"shortNames":[{"value":"fMLP receptor"}]}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"25109685"}],"value":"FPR1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P33766"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10514456"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15153520"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1712023"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2161213"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2176894"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24108355"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25109685"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25605714"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26516201"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35217703"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36064945"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"10514456"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"1712023"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"2161213"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"2176894"}],"value":"Pattern recognition G protein-coupled receptor (PRR/GPCR) involved in innate recognition of N-formyl-methionyl peptides derived from invading microbes and host mitochondria as pathogen- and damage-associated molecular patterns (PAMPs and DAMPs). Functions as a sensor of PAMPs and DAMPs released upon microbial infection or tissue damage, triggering immune cell activation and chemotaxis to eliminate pathogens and restore tissue homeostasis (PubMed:24108355, PubMed:25605714, PubMed:35217703, PubMed:36064945). Peptide binding leads to conformational changes coupled to heterotrimeric G(i) protein signaling. Upon GDP to GTP conversion, G(i)-alpha subunit dissociates from G-beta and G-gamma subunits. Free G(i)-alpha subunit inhibits cyclic adenylate cyclase and cAMP synthesis whereas the G-beta and G-gamma dimer activates downstream phospholipase C-beta and phosphoinositide 3-kinase signaling cascades leading to Ca(2+) influx (PubMed:10514456, PubMed:15153520, PubMed:1712023, PubMed:25605714, PubMed:35217703, PubMed:36064945). Displays two affinity states for peptide agonists, low and high, likely accounting for selective signaling of myeloid cell functions at different phases of the inflammatory response. Subnanomolar concentrations of peptide agonists induce myeloid cell chemotaxis, whereas micromolar concentrations trigger degranulation and superoxide production (PubMed:2161213, PubMed:2176894, PubMed:24108355, PubMed:25605714). May recognize a myriad of bacterial signal peptides indicative of an evolutionary conserved detection mechanism in host defense against bacterial infection. Triggers bactericidal functions of neutrophils and phagocytes in response to N-formyl-Met-Leu-Phe (fMLF) which is part of the signal peptide sequences of hundreds distinct bacterial strains (PubMed:25605714). In the homeostatic wound healing response to tissue injury, senses 'necrotaxis' DAMP-type signals released in the form of mitochondria-derived N-formylated peptides and guides neutrophil trafficking toward necrotic cells within the injury site (By similarity). In the context of antitumor immunity, interacts with ANXA1 and guides dendritic cell positioning in close proximity to necrotic tumor cells, allowing for tumor-associated antigen uptake and cross-presentation to T cells (PubMed:24108355, PubMed:26516201). Receptor for TAFA4, mediates its effects on chemoattracting macrophages, promoting phagocytosis and increasing reactive oxygen species (ROS) release (PubMed:25109685). Receptor for cathepsin CTSG, leading to increased phagocyte chemotaxis (PubMed:15210802). Beyond canonical N-terminal formylated peptide agonists, can also be activated by C-terminal amidated peptides, which appear to all share a tripartite structure motif oriented around a carboxyl group (PubMed:24108355, PubMed:25605714). Differential signaling is also defined by receptor oligomerization state. Pro-resolving ligands, such as lipoxin A4 or ANXA1, induce the formation of FPR1:FPR2 heterodimers triggering proapoptotic JNK pathway in neutrophils (PubMed:24108355)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31534221"}],"value":"(Microbial infection) Used by Y. pestis as a receptor on human immune cells. Upon infection, Y. pestis releases N-formyl peptides that activate FPR1-mediated immune signaling and chemotaxis. This leads to Y. pestis docking on FPR1 via the lcrV needle cap protein of its type III secretion system (T3SS) followed by the delivery of effector proteins into host immune cells, ultimately triggering immune cell apoptosis"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15153520"}],"value":"(Microbial infection) Interacts with S.aureus chemotaxis inhibitory protein (CHIPS); the interaction blocks the receptor and may thus inhibit the immune response"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31534221"}],"value":"(Microbial infection) Interacts with lcrV, the needle cap protein of the Y. pestis type III secretion system; this interaction promotes the translocation of bacterial effectors into host immune cells including neutrophils, macrophages and dendritic cells, thus targeting them for destruction"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24108355"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35217703"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36064945"}],"value":"Homodimer (PubMed:24108355). Heterodimer with FPR2 or FPR3; the heterodimerization with FPR2 is potentiated in response to anti-inflammatory agonists such as lipoxin A4 and ANXA1 (PubMed:24108355). Forms a complex with heterotrimeric G(i) protein composed of GNAI1, GNB1 and GNG2 subunits (PubMed:35217703, PubMed:36064945)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P21462","intActId":"EBI-2869495"},"interactantTwo":{"uniProtKBAccession":"P25098","geneName":"GRK2","intActId":"EBI-3904795"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P21462","intActId":"EBI-2869495"},"interactantTwo":{"uniProtKBAccession":"O15264","geneName":"MAPK13","intActId":"EBI-2116951"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15210802"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25109685"}],"value":"Internalizes in presence of its ligands, fMLP, TAFA4 and CTSG"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15153520"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2176894"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24108355"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25109685"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"10514456"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000255"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25605714"}],"value":"Monocytes (at protein level) (PubMed:25605714). Neutrophils"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10514456"}],"value":"Phosphorylated; which is necessary for desensitization"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31534221"}],"value":"Common FPR1 variations may have been selected to enhance human resistance to infections. FRP1 p.Arg190Trp is identified as an allele that protect neutrophils from destruction by Y. pestis type III secretion system"}],"commentType":"POLYMORPHISM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00521"}],"value":"Belongs to the G protein-coupled receptor 1 family"}],"commentType":"SIMILARITY"},{"commentType":"WEB RESOURCE","resourceName":"Atlas of Genetics and Cytogenetics in Oncology and Haematology","resourceUrl":"https://atlasgeneticsoncology.org/gene/44328/FPR1","ftp":false}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":350,"modifier":"EXACT"}},"description":"N-formyl peptide receptor 1","featureId":"PRO_0000069444"},{"type":"Topological domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":27,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":50,"modifier":"EXACT"}},"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":51,"modifier":"EXACT"},"end":{"value":61,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":62,"modifier":"EXACT"},"end":{"value":83,"modifier":"EXACT"}},"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":84,"modifier":"EXACT"},"end":{"value":100,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":101,"modifier":"EXACT"},"end":{"value":121,"modifier":"EXACT"}},"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":122,"modifier":"EXACT"},"end":{"value":140,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":141,"modifier":"EXACT"},"end":{"value":162,"modifier":"EXACT"}},"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":163,"modifier":"EXACT"},"end":{"value":205,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":206,"modifier":"EXACT"},"end":{"value":226,"modifier":"EXACT"}},"description":"Helical; Name=5","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":227,"modifier":"EXACT"},"end":{"value":242,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":243,"modifier":"EXACT"},"end":{"value":266,"modifier":"EXACT"}},"description":"Helical; Name=6","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":267,"modifier":"EXACT"},"end":{"value":285,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":286,"modifier":"EXACT"},"end":{"value":305,"modifier":"EXACT"}},"description":"Helical; Name=7","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":306,"modifier":"EXACT"},"end":{"value":350,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Region","location":{"start":{"value":325,"modifier":"EXACT"},"end":{"value":350,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":326,"modifier":"EXACT"},"end":{"value":341,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Binding site","location":{"start":{"value":106,"modifier":"EXACT"},"end":{"value":106,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:235462"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36064945"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7VFX"}],"ligand":{"name":"N(alpha)-formyl-L-methionyl-L-isoleucyl-L-phenylalanyl-L-leucine","id":"ChEBI:CHEBI:235462"}},{"type":"Binding site","location":{"start":{"value":106,"modifier":"EXACT"},"end":{"value":106,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:235463"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35217703"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7T6T"}],"ligand":{"name":"N(alpha)-formyl-L-methionyl-L-leucyl-L-phenylalanyl-L-isoleucyl-L-isoleucine","id":"ChEBI:CHEBI:235463"}},{"type":"Binding site","location":{"start":{"value":201,"modifier":"EXACT"},"end":{"value":201,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:235462"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36064945"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7VFX"}],"ligand":{"name":"N(alpha)-formyl-L-methionyl-L-isoleucyl-L-phenylalanyl-L-leucine","id":"ChEBI:CHEBI:235462"}},{"type":"Binding site","location":{"start":{"value":201,"modifier":"EXACT"},"end":{"value":201,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:194314"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36064945"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7EUO"}],"ligand":{"name":"N(alpha)-formyl-L-methionyl-L-leucyl-L-phenylalanine","id":"ChEBI:CHEBI:194314"}},{"type":"Binding site","location":{"start":{"value":201,"modifier":"EXACT"},"end":{"value":201,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:235463"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35217703"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7T6T"}],"ligand":{"name":"N(alpha)-formyl-L-methionyl-L-leucyl-L-phenylalanyl-L-isoleucyl-L-isoleucine","id":"ChEBI:CHEBI:235463"}},{"type":"Binding site","location":{"start":{"value":205,"modifier":"EXACT"},"end":{"value":205,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:235462"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36064945"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7VFX"}],"ligand":{"name":"N(alpha)-formyl-L-methionyl-L-isoleucyl-L-phenylalanyl-L-leucine","id":"ChEBI:CHEBI:235462"}},{"type":"Binding site","location":{"start":{"value":205,"modifier":"EXACT"},"end":{"value":205,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:194314"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36064945"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7EUO"}],"ligand":{"name":"N(alpha)-formyl-L-methionyl-L-leucyl-L-phenylalanine","id":"ChEBI:CHEBI:194314"}},{"type":"Binding site","location":{"start":{"value":205,"modifier":"EXACT"},"end":{"value":205,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:235463"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35217703"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7T6T"}],"ligand":{"name":"N(alpha)-formyl-L-methionyl-L-leucyl-L-phenylalanyl-L-isoleucyl-L-isoleucine","id":"ChEBI:CHEBI:235463"}},{"type":"Binding site","location":{"start":{"value":257,"modifier":"EXACT"},"end":{"value":257,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:235462"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36064945"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7VFX"}],"ligand":{"name":"N(alpha)-formyl-L-methionyl-L-isoleucyl-L-phenylalanyl-L-leucine","id":"ChEBI:CHEBI:235462"}},{"type":"Binding site","location":{"start":{"value":257,"modifier":"EXACT"},"end":{"value":257,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:194314"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36064945"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7EUO"}],"ligand":{"name":"N(alpha)-formyl-L-methionyl-L-leucyl-L-phenylalanine","id":"ChEBI:CHEBI:194314"}},{"type":"Binding site","location":{"start":{"value":257,"modifier":"EXACT"},"end":{"value":257,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:235463"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35217703"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7T6T"}],"ligand":{"name":"N(alpha)-formyl-L-methionyl-L-leucyl-L-phenylalanyl-L-isoleucyl-L-isoleucine","id":"ChEBI:CHEBI:235463"}},{"type":"Modified residue","location":{"start":{"value":328,"modifier":"EXACT"},"end":{"value":328,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Modified residue","location":{"start":{"value":329,"modifier":"EXACT"},"end":{"value":329,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Modified residue","location":{"start":{"value":331,"modifier":"EXACT"},"end":{"value":331,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Modified residue","location":{"start":{"value":332,"modifier":"EXACT"},"end":{"value":332,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Modified residue","location":{"start":{"value":334,"modifier":"EXACT"},"end":{"value":334,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Modified residue","location":{"start":{"value":336,"modifier":"EXACT"},"end":{"value":336,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Modified residue","location":{"start":{"value":338,"modifier":"EXACT"},"end":{"value":338,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Modified residue","location":{"start":{"value":339,"modifier":"EXACT"},"end":{"value":339,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Glycosylation","location":{"start":{"value":4,"modifier":"EXACT"},"end":{"value":4,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":10,"modifier":"EXACT"},"end":{"value":10,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Disulfide bond","location":{"start":{"value":98,"modifier":"EXACT"},"end":{"value":176,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00521"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35217703"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36064945"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7EUO"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7VFX"}]},{"type":"Natural variant","location":{"start":{"value":11,"modifier":"EXACT"},"end":{"value":11,"modifier":"EXACT"}},"description":"in dbSNP:rs5030878","featureCrossReferences":[{"database":"dbSNP","id":"rs5030878"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.7"}],"featureId":"VAR_055915","alternativeSequence":{"originalSequence":"I","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":101,"modifier":"EXACT"},"end":{"value":101,"modifier":"EXACT"}},"description":"in dbSNP:rs2070745","featureCrossReferences":[{"database":"dbSNP","id":"rs2070745"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2161213"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2176894"}],"featureId":"VAR_003476","alternativeSequence":{"originalSequence":"V","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":190,"modifier":"EXACT"},"end":{"value":190,"modifier":"EXACT"}},"description":"confers resistance to Y. pestis infection by protecting immune cells from the type III secretion system T3SS; reduces T3SS-mediated translocation of effector proteins into neutrophils and macrophages; impairs monocyte chemotaxis towards fMLF and Y. pestis; no effect on protein expression and localization at the cell surface; dbSNP:rs5030880","featureCrossReferences":[{"database":"dbSNP","id":"rs5030880"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31534221"}],"featureId":"VAR_055916","alternativeSequence":{"originalSequence":"R","alternativeSequences":["W"]}},{"type":"Natural variant","location":{"start":{"value":192,"modifier":"EXACT"},"end":{"value":192,"modifier":"EXACT"}},"description":"in dbSNP:rs1042229","featureCrossReferences":[{"database":"dbSNP","id":"rs1042229"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1612600"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.7"}],"featureId":"VAR_003477","alternativeSequence":{"originalSequence":"N","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":346,"modifier":"EXACT"},"end":{"value":346,"modifier":"EXACT"}},"description":"loss of interactions between peripheral blood mononuclear cells and necrotic tumor cells; associated with reduced metastasis-free survival and overall survival in breast cancer and colorectal cancer patients receiving chemotherapy; dbSNP:rs867228","featureCrossReferences":[{"database":"dbSNP","id":"rs867228"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2161213"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2176894"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26516201"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.5"}],"featureId":"VAR_003478","alternativeSequence":{"originalSequence":"E","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":81,"modifier":"EXACT"},"end":{"value":81,"modifier":"EXACT"}},"description":"Slightly decreases intracellular cAMP reduction upon stimulation with N-formylated fMLF peptide.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36064945"}],"alternativeSequence":{"originalSequence":"F","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":84,"modifier":"EXACT"},"end":{"value":84,"modifier":"EXACT"}},"description":"Decreases intracellular cAMP reduction upon stimulation with N-formyl peptide fMLFII.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35217703"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["D"]}},{"type":"Mutagenesis","location":{"start":{"value":102,"modifier":"EXACT"},"end":{"value":102,"modifier":"EXACT"}},"description":"Slightly decreases intracellular cAMP reduction upon stimulation with N-formyl peptide fMLF. Slightly decreases the agonist potency of non-formylated WKYMVm peptide.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36064945"}],"alternativeSequence":{"originalSequence":"F","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":102,"modifier":"EXACT"},"end":{"value":102,"modifier":"EXACT"}},"description":"Decreases intracellular cAMP reduction upon stimulation with N-formyl peptide fMLFII.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35217703"}],"alternativeSequence":{"originalSequence":"F","alternativeSequences":["H"]}},{"type":"Mutagenesis","location":{"start":{"value":106,"modifier":"EXACT"},"end":{"value":106,"modifier":"EXACT"}},"description":"Abolishes the response to N-formyl peptides fMLF, fMIFL and fMLFII.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35217703"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36064945"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":106,"modifier":"EXACT"},"end":{"value":106,"modifier":"EXACT"}},"description":"Abolishes the response to N-formyl peptides fMLF and fMIFL.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36064945"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["N"]}},{"type":"Mutagenesis","location":{"start":{"value":109,"modifier":"EXACT"},"end":{"value":109,"modifier":"EXACT"}},"description":"Slightly decreases intracellular cAMP reduction upon stimulation with N-formyl peptide fMLF. Decreases the agonist potency of non-formylated WKYMVm peptide.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36064945"}],"alternativeSequence":{"originalSequence":"L","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":110,"modifier":"EXACT"},"end":{"value":110,"modifier":"EXACT"}},"description":"Slightly decreases intracellular cAMP reduction upon stimulation with N-formyl peptide fMLF.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36064945"}],"alternativeSequence":{"originalSequence":"F","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":178,"modifier":"EXACT"},"end":{"value":178,"modifier":"EXACT"}},"description":"Decreases the agonist potency of non-formylated WKYMVm peptide.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36064945"}],"alternativeSequence":{"originalSequence":"F","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":201,"modifier":"EXACT"},"end":{"value":201,"modifier":"EXACT"}},"description":"Abolishes the response to N-formyl peptide fMLF. Decreases intracellular cAMP reduction upon stimulation with N-formyl peptides fMIFL and fMLFII. Abolishes the response to fMIFL; when associated with A-205. Decreases the agonist potency of non-formylated WKYMVm peptide.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35217703"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36064945"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":205,"modifier":"EXACT"},"end":{"value":205,"modifier":"EXACT"}},"description":"Abolishes the response to N-formyl peptide fMLF. Decreases intracellular cAMP reduction upon stimulation with N-formyl peptides fMIFL and fMLFII. Abolishes the response to fMIFL; when associated with A-201. Slightly decreases the agonist potency of non-formylated WKYMVm peptide.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35217703"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36064945"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":257,"modifier":"EXACT"},"end":{"value":257,"modifier":"EXACT"}},"description":"Decreases intracellular cAMP reduction upon stimulation with N-formyl peptide fMLFII.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35217703"}],"alternativeSequence":{"originalSequence":"Y","alternativeSequences":["F"]}},{"type":"Mutagenesis","location":{"start":{"value":265,"modifier":"EXACT"},"end":{"value":265,"modifier":"EXACT"}},"description":"Decreases the agonist potency of non-formylated WKYMVm peptide.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36064945"}],"alternativeSequence":{"originalSequence":"T","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":277,"modifier":"EXACT"},"end":{"value":277,"modifier":"EXACT"}},"description":"No significant effect on intracellular cAMP reduction upon stimulation with N-formyl peptide fMLFII.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35217703"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["D"]}},{"type":"Mutagenesis","location":{"start":{"value":283,"modifier":"EXACT"},"end":{"value":283,"modifier":"EXACT"}},"description":"No significant effect on intracellular cAMP reduction upon stimulation with N-formyl peptide fMLF.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36064945"}],"alternativeSequence":{"originalSequence":"V","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":291,"modifier":"EXACT"},"end":{"value":291,"modifier":"EXACT"}},"description":"Slightly decreases intracellular cAMP reduction upon stimulation with N-formyl peptide fMLF.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36064945"}],"alternativeSequence":{"originalSequence":"F","alternativeSequences":["A"]}},{"type":"Sequence conflict","location":{"start":{"value":238,"modifier":"EXACT"},"end":{"value":238,"modifier":"EXACT"}},"description":"in Ref. 1; AAA36362","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["P"]}},{"type":"Helix","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":53,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7VFX"}]},{"type":"Helix","location":{"start":{"value":59,"modifier":"EXACT"},"end":{"value":75,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7VFX"}]},{"type":"Helix","location":{"start":{"value":78,"modifier":"EXACT"},"end":{"value":86,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7VFX"}]},{"type":"Turn","location":{"start":{"value":87,"modifier":"EXACT"},"end":{"value":89,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7VFX"}]},{"type":"Helix","location":{"start":{"value":95,"modifier":"EXACT"},"end":{"value":128,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7VFX"}]},{"type":"Helix","location":{"start":{"value":130,"modifier":"EXACT"},"end":{"value":136,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7VFX"}]},{"type":"Helix","location":{"start":{"value":139,"modifier":"EXACT"},"end":{"value":145,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7VFX"}]},{"type":"Helix","location":{"start":{"value":147,"modifier":"EXACT"},"end":{"value":163,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7VFX"}]},{"type":"Beta strand","location":{"start":{"value":164,"modifier":"EXACT"},"end":{"value":169,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7VFX"}]},{"type":"Turn","location":{"start":{"value":170,"modifier":"EXACT"},"end":{"value":172,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7VFX"}]},{"type":"Beta strand","location":{"start":{"value":173,"modifier":"EXACT"},"end":{"value":178,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7VFX"}]},{"type":"Helix","location":{"start":{"value":187,"modifier":"EXACT"},"end":{"value":204,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7VFX"}]},{"type":"Helix","location":{"start":{"value":205,"modifier":"EXACT"},"end":{"value":211,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7VFX"}]},{"type":"Helix","location":{"start":{"value":212,"modifier":"EXACT"},"end":{"value":230,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7VFX"}]},{"type":"Helix","location":{"start":{"value":237,"modifier":"EXACT"},"end":{"value":266,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7VFX"}]},{"type":"Helix","location":{"start":{"value":268,"modifier":"EXACT"},"end":{"value":272,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7VFX"}]},{"type":"Helix","location":{"start":{"value":278,"modifier":"EXACT"},"end":{"value":298,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7VFX"}]},{"type":"Helix","location":{"start":{"value":299,"modifier":"EXACT"},"end":{"value":303,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7VFX"}]},{"type":"Helix","location":{"start":{"value":306,"modifier":"EXACT"},"end":{"value":314,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7VFX"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-0145","category":"Biological process","name":"Chemotaxis"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0297","category":"Molecular function","name":"G protein-coupled receptor"},{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-0391","category":"Biological process","name":"Immunity"},{"id":"KW-0395","category":"Biological process","name":"Inflammatory response"},{"id":"KW-0399","category":"Biological process","name":"Innate immunity"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0807","category":"Molecular function","name":"Transducer"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"2161213","citationType":"journal article","authors":["Boulay F.","Tardif M.","Brouchon L.","Vignais P."],"citationCrossReferences":[{"database":"PubMed","id":"2161213"},{"database":"DOI","id":"10.1016/0006-291x(90)91143-g"}],"title":"Synthesis and use of a novel N-formyl peptide derivative to isolate a human N-formyl peptide receptor cDNA.","publicationDate":"1990","journal":"Biochem. Biophys. Res. Commun.","firstPage":"1103","lastPage":"1109","volume":"168"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]","FUNCTION","VARIANTS LEU-101 AND ALA-346"]},{"referenceNumber":2,"citation":{"id":"2176894","citationType":"journal article","authors":["Boulay F.","Tardif M.","Brouchon L.","Vignais P."],"citationCrossReferences":[{"database":"PubMed","id":"2176894"},{"database":"DOI","id":"10.1021/bi00502a016"}],"title":"The human N-formylpeptide receptor. Characterization of two cDNA isolates and evidence for a new subfamily of G-protein-coupled receptors.","publicationDate":"1990","journal":"Biochemistry","firstPage":"11123","lastPage":"11133","volume":"29"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]","FUNCTION","SUBCELLULAR LOCATION","VARIANTS LEU-101 AND ALA-346"]},{"referenceNumber":3,"citation":{"id":"1712023","citationType":"journal article","authors":["Murphy P.M.","McDermott D."],"citationCrossReferences":[{"database":"PubMed","id":"1712023"},{"database":"DOI","id":"10.1016/s0021-9258(18)98935-0"}],"title":"Functional expression of the human formyl peptide receptor in Xenopus oocytes requires a complementary human factor.","publicationDate":"1991","journal":"J. Biol. Chem.","firstPage":"12560","lastPage":"12567","volume":"266"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]","FUNCTION"]},{"referenceNumber":4,"citation":{"id":"1612600","citationType":"journal article","authors":["Bao L.","Gerard N.P.","Eddy R.L. Jr.","Shows T.B.","Gerard C."],"citationCrossReferences":[{"database":"PubMed","id":"1612600"},{"database":"DOI","id":"10.1016/0888-7543(92)90265-t"}],"title":"Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19.","publicationDate":"1992","journal":"Genomics","firstPage":"437","lastPage":"440","volume":"13"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]","VARIANT LYS-192"]},{"referenceNumber":5,"citation":{"id":"CI-E77VM1PJ3IM84","citationType":"submission","authors":["Perez H.D."],"publicationDate":"MAR-1993","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]","VARIANT ALA-346"]},{"referenceNumber":6,"citation":{"id":"8224916","citationType":"journal article","authors":["Murphy P.M.","Tiffany H.L.","McDermott D.","Ahuja S.K."],"citationCrossReferences":[{"database":"PubMed","id":"8224916"},{"database":"DOI","id":"10.1016/0378-1119(93)90653-k"}],"title":"Sequence and organization of the human N-formyl peptide receptor-encoding gene.","publicationDate":"1993","journal":"Gene","firstPage":"285","lastPage":"290","volume":"133"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":7,"citation":{"id":"CI-13OQVK8FDDK6C","citationType":"submission","authors":["Kopatz S.A.","Aronstam R.S.","Sharma S.V."],"title":"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org).","publicationDate":"MAY-2003","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]","VARIANTS THR-11 AND LYS-192"]},{"referenceNumber":8,"citation":{"id":"CI-4IUTJLP3044AK","citationType":"submission","authors":["Kalnine N.","Chen X.","Rolfs A.","Halleck A.","Hines L.","Eisenstein S.","Koundinya M.","Raphael J.","Moreira D.","Kelley T.","LaBaer J.","Lin Y.","Phelan M.","Farmer A."],"title":"Cloning of human full-length CDSs in BD Creator(TM) system donor vector.","publicationDate":"MAY-2003","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"]},{"referenceNumber":9,"citation":{"id":"15057824","citationType":"journal article","authors":["Grimwood J.","Gordon L.A.","Olsen A.S.","Terry A.","Schmutz J.","Lamerdin J.E.","Hellsten U.","Goodstein D.","Couronne O.","Tran-Gyamfi M.","Aerts A.","Altherr M.","Ashworth L.","Bajorek E.","Black S.","Branscomb E.","Caenepeel S.","Carrano A.V.","Caoile C.","Chan Y.M.","Christensen M.","Cleland C.A.","Copeland A.","Dalin E.","Dehal P.","Denys M.","Detter J.C.","Escobar J.","Flowers D.","Fotopulos D.","Garcia C.","Georgescu A.M.","Glavina T.","Gomez M.","Gonzales E.","Groza M.","Hammon N.","Hawkins T.","Haydu L.","Ho I.","Huang W.","Israni S.","Jett J.","Kadner K.","Kimball H.","Kobayashi A.","Larionov V.","Leem S.-H.","Lopez F.","Lou Y.","Lowry S.","Malfatti S.","Martinez D.","McCready P.M.","Medina C.","Morgan J.","Nelson K.","Nolan M.","Ovcharenko I.","Pitluck S.","Pollard M.","Popkie A.P.","Predki P.","Quan G.","Ramirez L.","Rash S.","Retterer J.","Rodriguez A.","Rogers S.","Salamov A.","Salazar A.","She X.","Smith D.","Slezak T.","Solovyev V.","Thayer N.","Tice H.","Tsai M.","Ustaszewska A.","Vo N.","Wagner M.","Wheeler J.","Wu K.","Xie G.","Yang J.","Dubchak I.","Furey T.S.","DeJong P.","Dickson M.","Gordon D.","Eichler E.E.","Pennacchio L.A.","Richardson P.","Stubbs L.","Rokhsar D.S.","Myers R.M.","Rubin E.M.","Lucas S.M."],"citationCrossReferences":[{"database":"PubMed","id":"15057824"},{"database":"DOI","id":"10.1038/nature02399"}],"title":"The DNA sequence and biology of human chromosome 19.","publicationDate":"2004","journal":"Nature","firstPage":"529","lastPage":"535","volume":"428"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":10,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Kidney","type":"TISSUE"}]},{"referenceNumber":11,"citation":{"id":"1445895","citationType":"journal article","authors":["Perez H.D.","Holmes R.","Kelly E.","McClary J.","Chou Q.","Andrews W.H."],"citationCrossReferences":[{"database":"PubMed","id":"1445895"},{"database":"DOI","id":"10.1021/bi00161a044"}],"title":"Cloning of the gene coding for a human receptor for formyl peptides. Characterization of a promoter region and evidence for polymorphic expression.","publicationDate":"1992","journal":"Biochemistry","firstPage":"11595","lastPage":"11599","volume":"31"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF 1-5"],"referenceComments":[{"value":"Bone marrow","type":"TISSUE"}]},{"referenceNumber":12,"citation":{"id":"10514456","citationType":"journal article","authors":["Maestes D.C.","Potter R.M.","Prossnitz E.R."],"citationCrossReferences":[{"database":"PubMed","id":"10514456"},{"database":"DOI","id":"10.1074/jbc.274.42.29791"}],"title":"Differential phosphorylation paradigms dictate desensitization and internalization of the N-formyl peptide receptor.","publicationDate":"1999","journal":"J. Biol. Chem.","firstPage":"29791","lastPage":"29795","volume":"274"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION","PHOSPHORYLATION AT SER-328; THR-329; THR-331; SER-332; THR-334; THR-336; SER-338 AND THR-339"]},{"referenceNumber":13,"citation":{"id":"15153520","citationType":"journal article","authors":["Postma B.","Poppelier M.J.J.G.","van Galen J.C.","Prossnitz E.R.","van Strijp J.A.G.","de Haas C.J.C.","van Kessel K.P.M."],"citationCrossReferences":[{"database":"PubMed","id":"15153520"},{"database":"DOI","id":"10.4049/jimmunol.172.11.6994"}],"title":"Chemotaxis inhibitory protein of Staphylococcus aureus binds specifically to the C5a and formylated peptide receptor.","publicationDate":"2004","journal":"J. Immunol.","firstPage":"6994","lastPage":"7001","volume":"172"},"referencePositions":["FUNCTION","INTERACTION WITH CHIPS (MICROBIAL INFECTION)","SUBCELLULAR LOCATION"]},{"referenceNumber":14,"citation":{"id":"15210802","citationType":"journal article","authors":["Sun R.","Iribarren P.","Zhang N.","Zhou Y.","Gong W.","Cho E.H.","Lockett S.","Chertov O.","Bednar F.","Rogers T.J.","Oppenheim J.J.","Wang J.M."],"citationCrossReferences":[{"database":"PubMed","id":"15210802"},{"database":"DOI","id":"10.4049/jimmunol.173.1.428"}],"title":"Identification of neutrophil granule protein cathepsin G as a novel chemotactic agonist for the G protein-coupled formyl peptide receptor.","publicationDate":"2004","journal":"J. Immunol.","firstPage":"428","lastPage":"436","volume":"173"},"referencePositions":["FUNCTION"]},{"referenceNumber":15,"citation":{"id":"24108355","citationType":"journal article","authors":["Cooray S.N.","Gobbetti T.","Montero-Melendez T.","McArthur S.","Thompson D.","Clark A.J.","Flower R.J.","Perretti M."],"citationCrossReferences":[{"database":"PubMed","id":"24108355"},{"database":"DOI","id":"10.1073/pnas.1308253110"}],"title":"Ligand-specific conformational change of the G-protein-coupled receptor ALX/FPR2 determines proresolving functional responses.","publicationDate":"2013","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"18232","lastPage":"18237","volume":"110"},"referencePositions":["FUNCTION","SUBUNIT","INTERACTION WITH FPR2 AND FPR3","SUBCELLULAR LOCATION"]},{"referenceNumber":16,"citation":{"id":"25109685","citationType":"journal article","authors":["Wang W.","Li T.","Wang X.","Yuan W.","Cheng Y.","Zhang H.","Xu E.","Zhang Y.","Shi S.","Ma D.","Han W."],"citationCrossReferences":[{"database":"PubMed","id":"25109685"},{"database":"DOI","id":"10.1038/cmi.2014.61"}],"title":"FAM19A4 is a novel cytokine ligand of formyl peptide receptor 1 (FPR1) and is able to promote the migration and phagocytosis of macrophages.","publicationDate":"2015","journal":"Cell. Mol. Immunol.","firstPage":"615","lastPage":"624","volume":"12"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION"]},{"referenceNumber":17,"citation":{"id":"25605714","citationType":"journal article","authors":["Bufe B.","Schumann T.","Kappl R.","Bogeski I.","Kummerow C.","Podgorska M.","Smola S.","Hoth M.","Zufall F."],"citationCrossReferences":[{"database":"PubMed","id":"25605714"},{"database":"DOI","id":"10.1074/jbc.m114.626747"}],"title":"Recognition of bacterial signal peptides by mammalian formyl peptide receptors: a new mechanism for sensing pathogens.","publicationDate":"2015","journal":"J. Biol. Chem.","firstPage":"7369","lastPage":"7387","volume":"290"},"referencePositions":["FUNCTION","TISSUE SPECIFICITY"]},{"referenceNumber":18,"citation":{"id":"26516201","citationType":"journal article","authors":["Vacchelli E.","Ma Y.","Baracco E.E.","Sistigu A.","Enot D.P.","Pietrocola F.","Yang H.","Adjemian S.","Chaba K.","Semeraro M.","Signore M.","De Ninno A.","Lucarini V.","Peschiaroli F.","Businaro L.","Gerardino A.","Manic G.","Ulas T.","Guenther P.","Schultze J.L.","Kepp O.","Stoll G.","Lefebvre C.","Mulot C.","Castoldi F.","Rusakiewicz S.","Ladoire S.","Apetoh L.","Bravo-San Pedro J.M.","Lucattelli M.","Delarasse C.","Boige V.","Ducreux M.","Delaloge S.","Borg C.","Andre F.","Schiavoni G.","Vitale I.","Laurent-Puig P.","Mattei F.","Zitvogel L.","Kroemer G."],"citationCrossReferences":[{"database":"PubMed","id":"26516201"},{"database":"DOI","id":"10.1126/science.aad0779"}],"title":"Chemotherapy-induced antitumor immunity requires formyl peptide receptor 1.","publicationDate":"2015","journal":"Science","firstPage":"972","lastPage":"978","volume":"350"},"referencePositions":["FUNCTION","CHARACTERIZATION OF VARIANT ALA-346"]},{"referenceNumber":19,"citation":{"id":"31534221","citationType":"journal article","authors":["Osei-Owusu P.","Charlton T.M.","Kim H.K.","Missiakas D.","Schneewind O."],"citationCrossReferences":[{"database":"PubMed","id":"31534221"},{"database":"DOI","id":"10.1038/s41586-019-1570-z"}],"title":"FPR1 is the plague receptor on host immune cells.","publicationDate":"2019","journal":"Nature","firstPage":"57","lastPage":"62","volume":"574"},"referencePositions":["FUNCTION (MICROBIAL INFECTION)","INTERACTION WITH LCRV (MICROBIAL INFECTION)","POLYMORPHISM","CHARACTERIZATION OF VARIANT TRP-190"]},{"referenceNumber":20,"citation":{"id":"35217703","citationType":"journal article","authors":["Zhuang Y.","Wang L.","Guo J.","Sun D.","Wang Y.","Liu W.","Xu H.E.","Zhang C."],"citationCrossReferences":[{"database":"PubMed","id":"35217703"},{"database":"DOI","id":"10.1038/s41467-022-28586-0"}],"title":"Molecular recognition of formylpeptides and diverse agonists by the formylpeptide receptors FPR1 and FPR2.","publicationDate":"2022","journal":"Nat. Commun.","firstPage":"1054","lastPage":"1054","volume":"13"},"referencePositions":["STRUCTURE BY ELECTRON MICROSCOPY (3.20 ANGSTROMS) OF 1-333 IN COMPLEX WITH GNAI1; GNB1; GNG2 AND N-FORMYL-METHIONYL PEPTIDE","DISULFIDE BONDS","FUNCTION","SUBUNIT","MUTAGENESIS OF ARG-84; PHE-102; ASP-106; ARG-201; ARG-205; TYR-257 AND LYS-277"]},{"referenceNumber":21,"citation":{"id":"36064945","citationType":"journal article","authors":["Chen G.","Wang X.","Liao Q.","Ge Y.","Jiao H.","Chen Q.","Liu Y.","Lyu W.","Zhu L.","van Zundert G.C.P.","Robertson M.J.","Skiniotis G.","Du Y.","Hu H.","Ye R.D."],"citationCrossReferences":[{"database":"PubMed","id":"36064945"},{"database":"DOI","id":"10.1038/s41467-022-32822-y"}],"title":"Structural basis for recognition of N-formyl peptides as pathogen-associated molecular patterns.","publicationDate":"2022","journal":"Nat. Commun.","firstPage":"5232","lastPage":"5232","volume":"13"},"referencePositions":["STRUCTURE BY ELECTRON MICROSCOPY (2.80 ANGSTROMS) IN COMPLEX WITH GNAI1; GNB1; GNG2 AND N-FORMYL-METHIONYL PEPTIDES","DISULFIDE BONDS","SUBUNIT","FUNCTION","MUTAGENESIS OF PHE-81; PHE-102; ASP-106; LEU-109; PHE-110; PHE-178; ARG-201; ARG-205; THR-265; VAL-283 AND PHE-291"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"M37128","properties":[{"key":"ProteinId","value":"AAA36362.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"M60626","properties":[{"key":"ProteinId","value":"AAA35846.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"M60627","properties":[{"key":"ProteinId","value":"AAA35847.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"L10820","properties":[{"key":"ProteinId","value":"AAA16863.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AY301273","properties":[{"key":"ProteinId","value":"AAP58403.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BT007429","properties":[{"key":"ProteinId","value":"AAP36097.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AC018755","properties":[{"key":"ProteinId","value":"AAF87842.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC005315","properties":[{"key":"ProteinId","value":"AAH05315.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"S49810","properties":[{"key":"ProteinId","value":"AAD14906.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS12839.1","properties":[{"key":"Description","value":"-"}]},{"database":"PIR","id":"JC2014","properties":[{"key":"EntryName","value":"A42009"}]},{"database":"RefSeq","id":"NP_001180235.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001193306.2"}]},{"database":"RefSeq","id":"NP_002020.1","properties":[{"key":"NucleotideSequenceId","value":"NM_002029.4"}]},{"database":"PDB","id":"7EUO","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.90 A"},{"key":"Chains","value":"R=1-350"}]},{"database":"PDB","id":"7T6T","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.20 A"},{"key":"Chains","value":"R=1-333"}]},{"database":"PDB","id":"7VFX","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.80 A"},{"key":"Chains","value":"R=1-350"}]},{"database":"PDB","id":"7WVU","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.30 A"},{"key":"Chains","value":"R=2-321"}]},{"database":"PDB","id":"9KFT","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.06 A"},{"key":"Chains","value":"R=1-350"}]},{"database":"PDBsum","id":"7EUO","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7T6T","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7VFX","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7WVU","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9KFT","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"P21462","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-25727","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-31323","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-31962","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-32858","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-62300","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P21462","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"108640","properties":[{"key":"Interactions","value":"152"}]},{"database":"FunCoup","id":"P21462","properties":[{"key":"Number of interactors","value":"641"}]},{"database":"IntAct","id":"P21462","properties":[{"key":"Interactions","value":"224"}]},{"database":"NDEx","id":"IQUERY-CP-FPR1","properties":[{"key":"Evidences","value":"5 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000471493","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"P21462","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL3359","properties":[{"key":"Description","value":"-"}]},{"database":"DrugBank","id":"DB00716","properties":[{"key":"GenericName","value":"Nedocromil"}]},{"database":"DrugBank","id":"DB11656","properties":[{"key":"GenericName","value":"Rebamipide"}]},{"database":"DrugCentral","id":"P21462","properties":[{"key":"Description","value":"-"}]},{"database":"GuidetoPHARMACOLOGY","id":"222","properties":[{"key":"Description","value":"-"}]},{"database":"GlyCosmos","id":"P21462","properties":[{"key":"glycosylation","value":"2 sites, No reported glycans"}]},{"database":"GlyGen","id":"P21462","properties":[{"key":"glycosylation","value":"3 sites"}]},{"database":"iPTMnet","id":"P21462","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"P21462","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"FPR1","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"288558848","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"P21462","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000471493","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P21462","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"53872","properties":[{"key":"Description","value":"-"}]},{"database":"ABCD","id":"P21462","properties":[{"key":"antibodies","value":"6 sequenced antibodies"}]},{"database":"Antibodypedia","id":"19049","properties":[{"key":"antibodies","value":"431 antibodies from 36 providers"}]},{"database":"DNASU","id":"2357","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000304748.5","properties":[{"key":"ProteinId","value":"ENSP00000302707.3"},{"key":"GeneId","value":"ENSG00000171051.11"}]},{"database":"Ensembl","id":"ENST00000594900.2","properties":[{"key":"ProteinId","value":"ENSP00000470750.2"},{"key":"GeneId","value":"ENSG00000171051.11"}]},{"database":"Ensembl","id":"ENST00000595042.5","properties":[{"key":"ProteinId","value":"ENSP00000471493.1"},{"key":"GeneId","value":"ENSG00000171051.11"}]},{"database":"Ensembl","id":"ENST00000600815.2","properties":[{"key":"ProteinId","value":"ENSP00000472936.2"},{"key":"GeneId","value":"ENSG00000171051.11"}]},{"database":"Ensembl","id":"ENST00000881808.1","properties":[{"key":"ProteinId","value":"ENSP00000551867.1"},{"key":"GeneId","value":"ENSG00000171051.11"}]},{"database":"Ensembl","id":"ENST00000881809.1","properties":[{"key":"ProteinId","value":"ENSP00000551868.1"},{"key":"GeneId","value":"ENSG00000171051.11"}]},{"database":"Ensembl","id":"ENST00000881810.1","properties":[{"key":"ProteinId","value":"ENSP00000551869.1"},{"key":"GeneId","value":"ENSG00000171051.11"}]},{"database":"Ensembl","id":"ENST00000930484.1","properties":[{"key":"ProteinId","value":"ENSP00000600543.1"},{"key":"GeneId","value":"ENSG00000171051.11"}]},{"database":"Ensembl","id":"ENST00000948394.1","properties":[{"key":"ProteinId","value":"ENSP00000618453.1"},{"key":"GeneId","value":"ENSG00000171051.11"}]},{"database":"Ensembl","id":"ENST00000948395.1","properties":[{"key":"ProteinId","value":"ENSP00000618454.1"},{"key":"GeneId","value":"ENSG00000171051.11"}]},{"database":"Ensembl","id":"ENST00000948396.1","properties":[{"key":"ProteinId","value":"ENSP00000618455.1"},{"key":"GeneId","value":"ENSG00000171051.11"}]},{"database":"GeneID","id":"2357","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:2357","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000304748.5","properties":[{"key":"ProteinId","value":"ENSP00000302707.3"},{"key":"RefSeqNucleotideId","value":"NM_002029.4"},{"key":"RefSeqProteinId","value":"NP_002020.1"}]},{"database":"UCSC","id":"uc002pxq.4","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:3826","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA28244","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"2357","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"2357","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"FPR1","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:3826","properties":[{"key":"GeneName","value":"FPR1"}]},{"database":"HPA","id":"ENSG00000171051","properties":[{"key":"ExpressionPatterns","value":"Tissue enhanced (bone marrow, lymphoid tissue)"}]},{"database":"MalaCards","id":"FPR1","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"136537","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000171051","properties":[{"key":"Description","value":"-"}]},{"database":"Orphanet","id":"447740","properties":[{"key":"Disease","value":"Aggressive periodontitis"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000171051","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG3656","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT01140000282544","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P21462","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"WFMCKFI","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"6088892at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"P21462","properties":[{"key":"Number of GO annotations","value":"7 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"P21462","properties":[{"key":"Description","value":"-"}]},{"database":"BRENDA","id":"3.1.4.4","properties":[{"key":"OrganismId","value":"2681"}]},{"database":"PathwayCommons","id":"P21462","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-418594","properties":[{"key":"PathwayName","value":"G alpha (i) signalling events"}]},{"database":"Reactome","id":"R-HSA-444473","properties":[{"key":"PathwayName","value":"Formyl peptide receptors bind formyl peptides and many other ligands"}]},{"database":"Reactome","id":"R-HSA-6783783","properties":[{"key":"PathwayName","value":"Interleukin-10 signaling"}]},{"database":"Reactome","id":"R-HSA-6798695","properties":[{"key":"PathwayName","value":"Neutrophil degranulation"}]},{"database":"SignaLink","id":"P21462","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"P21462","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000171051","properties":[{"key":"NominatedTarget","value":"Agora Nominated Target for Alzheimer's Disease"}]},{"database":"BioGRID-ORCS","id":"2357","properties":[{"key":"hits","value":"9 hits in 1143 CRISPR screens"}]},{"database":"ChiTaRS","id":"FPR1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GeneWiki","id":"Formyl_peptide_receptor_1","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"2357","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"P21462","properties":[{"key":"DevelopmentLevel","value":"Tchem"}]},{"database":"PRO","id":"PR:P21462","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 19"}]},{"database":"RNAct","id":"P21462","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000171051","properties":[{"key":"ExpressionPatterns","value":"Expressed in blood and 142 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"P21462","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0035577","properties":[{"key":"GoTerm","value":"C:azurophil granule membrane"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"ISS:ARUK-UCL"}]},{"database":"GO","id":"GO:0101003","properties":[{"key":"GoTerm","value":"C:ficolin-1-rich granule membrane"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"2161213"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15153520"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2176894"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24108355"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25109685"}]},{"database":"GO","id":"GO:0030667","properties":[{"key":"GoTerm","value":"C:secretory granule membrane"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0004875","properties":[{"key":"GoTerm","value":"F:complement receptor activity"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0004930","properties":[{"key":"GoTerm","value":"F:G protein-coupled receptor activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15210802"}]},{"database":"GO","id":"GO:0001664","properties":[{"key":"GoTerm","value":"F:G protein-coupled receptor binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10823817"}]},{"database":"GO","id":"GO:0004982","properties":[{"key":"GoTerm","value":"F:N-formyl peptide receptor activity"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12218158"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22859307"}]},{"database":"GO","id":"GO:0050786","properties":[{"key":"GoTerm","value":"F:RAGE receptor binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0005124","properties":[{"key":"GoTerm","value":"F:scavenger receptor binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0007188","properties":[{"key":"GoTerm","value":"P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"10889468"}]},{"database":"GO","id":"GO:0006935","properties":[{"key":"GoTerm","value":"P:chemotaxis"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"10857861"}]},{"database":"GO","id":"GO:0002430","properties":[{"key":"GoTerm","value":"P:complement receptor mediated signaling pathway"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0007186","properties":[{"key":"GoTerm","value":"P:G protein-coupled receptor signaling pathway"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"10823817"}]},{"database":"GO","id":"GO:0006954","properties":[{"key":"GoTerm","value":"P:inflammatory response"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0007200","properties":[{"key":"GoTerm","value":"P:phospholipase C-activating G protein-coupled receptor signaling pathway"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22859307"}]},{"database":"GO","id":"GO:0007204","properties":[{"key":"GoTerm","value":"P:positive regulation of cytosolic calcium ion concentration"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0007165","properties":[{"key":"GoTerm","value":"P:signal transduction"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"10820279"}]},{"database":"FunFam","id":"1.20.1070.10:FF:000034","properties":[{"key":"EntryName","value":"G-protein coupled receptor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1070.10","properties":[{"key":"EntryName","value":"Rhodopsin 7-helix transmembrane proteins"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000826","properties":[{"key":"EntryName","value":"Formyl_rcpt-rel"}]},{"database":"InterPro","id":"IPR000276","properties":[{"key":"EntryName","value":"GPCR_Rhodpsn"}]},{"database":"InterPro","id":"IPR017452","properties":[{"key":"EntryName","value":"GPCR_Rhodpsn_7TM"}]},{"database":"PANTHER","id":"PTHR24225","properties":[{"key":"EntryName","value":"CHEMOTACTIC RECEPTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR24225:SF15","properties":[{"key":"EntryName","value":"FMET-LEU-PHE RECEPTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00001","properties":[{"key":"EntryName","value":"7tm_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00526","properties":[{"key":"EntryName","value":"FMETLEUPHER"}]},{"database":"PRINTS","id":"PR00237","properties":[{"key":"EntryName","value":"GPCRRHODOPSN"}]},{"database":"SUPFAM","id":"SSF81321","properties":[{"key":"EntryName","value":"Family A G protein-coupled receptor-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00237","properties":[{"key":"EntryName","value":"G_PROTEIN_RECEP_F1_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50262","properties":[{"key":"EntryName","value":"G_PROTEIN_RECEP_F1_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"METNSSLPTNISGGTPAVSAGYLFLDIITYLVFAVTFVLGVLGNGLVIWVAGFRMTHTVTTISYLNLAVADFCFTSTLPFFMVRKAMGGHWPFGWFLCKFVFTIVDINLFGSVFLIALIALDRCVCVLHPVWTQNHRTVSLAKKVIIGPWVMALLLTLPVIIRVTTVPGKTGTVACTFNFSPWTNDPKERINVAVAMLTVRGIIRFIIGFSAPMSIVAVSYGLIATKIHKQGLIKSSRPLRVLSFVAAAFFLCWSPYQVVALIATVRIRELLQGMYKEIGIAVDVTSALAFFNSCLNPMLYVFMGQDFRERLIHALPASLERALTEDSTQTSDTATNSTLPSAEVELQAK","length":350,"molWeight":38446,"crc64":"06651DF820B1CBD1","md5":"0D6739237C1FBDA3CE3FE3ED449DCC64"},"extraAttributes":{"countByCommentType":{"FUNCTION":2,"SUBUNIT":3,"INTERACTION":2,"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1,"PTM":1,"POLYMORPHISM":1,"SIMILARITY":1,"WEB RESOURCE":1},"countByFeatureType":{"Chain":1,"Topological domain":8,"Transmembrane":7,"Region":1,"Compositional bias":1,"Binding site":11,"Modified residue":8,"Glycosylation":2,"Disulfide bond":1,"Natural variant":5,"Mutagenesis":16,"Sequence conflict":1,"Helix":15,"Turn":2,"Beta strand":2},"uniParcId":"UPI0000050484"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"M0R315","uniProtkbId":"M0R315_HUMAN","entryAudit":{"firstPublicDate":"2013-04-03","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2013-04-03","entryVersion":73,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000472936"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00042521"}],"value":"N-formylpeptide chemoattractant receptor"}},"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000472936"}],"value":"FPR1"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004651"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004651"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00521"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000688"}],"value":"Belongs to the G protein-coupled receptor 1 family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00025736"}],"value":"Belongs to the chemokine-like receptor (CMKLR) family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00521"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Transmembrane","location":{"start":{"value":27,"modifier":"EXACT"},"end":{"value":52,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":64,"modifier":"EXACT"},"end":{"value":82,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":94,"modifier":"EXACT"},"end":{"value":121,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":141,"modifier":"EXACT"},"end":{"value":162,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":43,"modifier":"EXACT"},"end":{"value":191,"modifier":"EXACT"}},"description":"G-protein coupled receptors family 1 profile","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50262"}]},{"type":"Non-terminal residue","location":{"start":{"value":191,"modifier":"EXACT"},"end":{"value":191,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000472936"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022500"}],"id":"KW-0145","category":"Biological process","name":"Chemotaxis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023040"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00521"}],"id":"KW-0297","category":"Molecular function","name":"G protein-coupled receptor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00521"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"M0R315"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"M0R315"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023170"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00521"}],"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023224"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00521"}],"id":"KW-0807","category":"Molecular function","name":"Transducer"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000688"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15057824","citationType":"journal article","authors":["Grimwood J.","Gordon L.A.","Olsen A.","Terry A.","Schmutz J.","Lamerdin J.","Hellsten U.","Goodstein D.","Couronne O.","Tran-Gyamfi M.","Aerts A.","Altherr M.","Ashworth L.","Bajorek E.","Black S.","Branscomb E.","Caenepeel S.","Carrano A.","Caoile C.","Chan Y.M.","Christensen M.","Cleland C.A.","Copeland A.","Dalin E.","Dehal P.","Denys M.","Detter J.C.","Escobar J.","Flowers D.","Fotopulos D.","Garcia C.","Georgescu A.M.","Glavina T.","Gomez M.","Gonzales E.","Groza M.","Hammon N.","Hawkins T.","Haydu L.","Ho I.","Huang W.","Israni S.","Jett J.","Kadner K.","Kimball H.","Kobayashi A.","Larionov V.","Leem S.H.","Lopez F.","Lou Y.","Lowry S.","Malfatti S.","Martinez D.","McCready P.","Medina C.","Morgan J.","Nelson K.","Nolan M.","Ovcharenko I.","Pitluck S.","Pollard M.","Popkie A.P.","Predki P.","Quan G.","Ramirez L.","Rash S.","Retterer J.","Rodriguez A.","Rogers S.","Salamov A.","Salazar A.","She X.","Smith D.","Slezak T.","Solovyev V.","Thayer N.","Tice H.","Tsai M.","Ustaszewska A.","Vo N.","Wagner M.","Wheeler J.","Wu K.","Xie G.","Yang J.","Dubchak I.","Furey T.S.","DeJong P.","Dickson M.","Gordon D.","Eichler E.E.","Pennacchio L.A.","Richardson P.","Stubbs L.","Rokhsar D.S.","Myers R.M.","Rubin E.M.","Lucas S.M."],"citationCrossReferences":[{"database":"PubMed","id":"15057824"},{"database":"DOI","id":"10.1038/nature02399"}],"title":"The DNA sequence and biology of human chromosome 19.","publicationDate":"2004","journal":"Nature","firstPage":"529","lastPage":"535","volume":"428"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000472936"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-V6MAQDITCKE2","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"FEB-2013","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000472936"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC005946","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC018755","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"M0R315","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"M0R315","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"M0R315","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"M0R315","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"19049","properties":[{"key":"antibodies","value":"431 antibodies from 36 providers"}]},{"database":"Ensembl","id":"ENST00000600815.1","properties":[{"key":"ProteinId","value":"ENSP00000472936.1"},{"key":"GeneId","value":"ENSG00000171051.9"}]},{"database":"UCSC","id":"uc061byt.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:3826","properties":[{"key":"GeneName","value":"FPR1"}]},{"database":"OpenTargets","id":"ENSG00000171051","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000171051","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT01140000282544","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_009579_8_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"WFMCKFI","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"6088892at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"FPR1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 19"}]},{"database":"Bgee","id":"ENSG00000171051","properties":[{"key":"ExpressionPatterns","value":"Expressed in blood and 142 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"M0R315","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0004930","properties":[{"key":"GoTerm","value":"F:G protein-coupled receptor activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"1.20.1070.10","properties":[{"key":"EntryName","value":"Rhodopsin 7-helix transmembrane proteins"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000826","properties":[{"key":"EntryName","value":"Formyl_rcpt-rel"}]},{"database":"InterPro","id":"IPR000276","properties":[{"key":"EntryName","value":"GPCR_Rhodpsn"}]},{"database":"InterPro","id":"IPR017452","properties":[{"key":"EntryName","value":"GPCR_Rhodpsn_7TM"}]},{"database":"PANTHER","id":"PTHR24225","properties":[{"key":"EntryName","value":"CHEMOTACTIC RECEPTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR24225:SF15","properties":[{"key":"EntryName","value":"FMET-LEU-PHE RECEPTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00001","properties":[{"key":"EntryName","value":"7tm_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00526","properties":[{"key":"EntryName","value":"FMETLEUPHER"}]},{"database":"PRINTS","id":"PR00237","properties":[{"key":"EntryName","value":"GPCRRHODOPSN"}]},{"database":"SUPFAM","id":"SSF81321","properties":[{"key":"EntryName","value":"Family A G protein-coupled receptor-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00237","properties":[{"key":"EntryName","value":"G_PROTEIN_RECEP_F1_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50262","properties":[{"key":"EntryName","value":"G_PROTEIN_RECEP_F1_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"METNSSLPTNISGGTPAVSAGYLFLDIITYLVFAVTFVLGVLGNGLVIWVAGFRMTHTVTTISYLNLAVADFCFTSTLPFFMVRKAMGGHWPFGWFLCKFVFTIVDINLFGSVFLIALIALDRCVCVLHPVWTQNHRTVSLAKKVIIGPWVMALLLTLPVIIRVTTVPGKTGTVACTFNFSPWTNDPKERI","length":191,"molWeight":21051,"crc64":"6E1326D1B510B4D9","md5":"1E49E6A8ADEDFE619D7224CD0ACD3336"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":2,"CAUTION":1},"countByFeatureType":{"Transmembrane":4,"Domain":1,"Non-terminal residue":1},"uniParcId":"UPI0002A47124"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"M0QZT0","uniProtkbId":"M0QZT0_HUMAN","entryAudit":{"firstPublicDate":"2013-04-03","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2016-10-05","entryVersion":64,"sequenceVersion":8},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000470750"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000470750"}],"value":"fMet-Leu-Phe receptor"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000470750"}],"value":"FPR1"}}],"features":[{"type":"Transmembrane","location":{"start":{"value":20,"modifier":"EXACT"},"end":{"value":38,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Non-terminal residue","location":{"start":{"value":39,"modifier":"EXACT"},"end":{"value":39,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000470750"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15057824","citationType":"journal article","authors":["Grimwood J.","Gordon L.A.","Olsen A.","Terry A.","Schmutz J.","Lamerdin J.","Hellsten U.","Goodstein D.","Couronne O.","Tran-Gyamfi M.","Aerts A.","Altherr M.","Ashworth L.","Bajorek E.","Black S.","Branscomb E.","Caenepeel S.","Carrano A.","Caoile C.","Chan Y.M.","Christensen M.","Cleland C.A.","Copeland A.","Dalin E.","Dehal P.","Denys M.","Detter J.C.","Escobar J.","Flowers D.","Fotopulos D.","Garcia C.","Georgescu A.M.","Glavina T.","Gomez M.","Gonzales E.","Groza M.","Hammon N.","Hawkins T.","Haydu L.","Ho I.","Huang W.","Israni S.","Jett J.","Kadner K.","Kimball H.","Kobayashi A.","Larionov V.","Leem S.H.","Lopez F.","Lou Y.","Lowry S.","Malfatti S.","Martinez D.","McCready P.","Medina C.","Morgan J.","Nelson K.","Nolan M.","Ovcharenko I.","Pitluck S.","Pollard M.","Popkie A.P.","Predki P.","Quan G.","Ramirez L.","Rash S.","Retterer J.","Rodriguez A.","Rogers S.","Salamov A.","Salazar A.","She X.","Smith D.","Slezak T.","Solovyev V.","Thayer N.","Tice H.","Tsai M.","Ustaszewska A.","Vo N.","Wagner M.","Wheeler J.","Wu K.","Xie G.","Yang J.","Dubchak I.","Furey T.S.","DeJong P.","Dickson M.","Gordon D.","Eichler E.E.","Pennacchio L.A.","Richardson P.","Stubbs L.","Rokhsar D.S.","Myers R.M.","Rubin E.M.","Lucas S.M."],"citationCrossReferences":[{"database":"PubMed","id":"15057824"},{"database":"DOI","id":"10.1038/nature02399"}],"title":"The DNA sequence and biology of human chromosome 19.","publicationDate":"2004","journal":"Nature","firstPage":"529","lastPage":"535","volume":"428"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000470750"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-V6MAQDITCKE2","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"FEB-2013","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000470750"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC005946","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC018755","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"M0QZT0","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"M0QZT0","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"19049","properties":[{"key":"antibodies","value":"431 antibodies from 36 providers"}]},{"database":"Ensembl","id":"ENST00000594900.1","properties":[{"key":"ProteinId","value":"ENSP00000470750.1"},{"key":"GeneId","value":"ENSG00000171051.9"}]},{"database":"UCSC","id":"uc061byu.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:3826","properties":[{"key":"GeneName","value":"FPR1"}]},{"database":"OpenTargets","id":"ENSG00000171051","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000171051","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT01140000282544","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_3322299_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"WFMCKFI","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"6088892at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"FPR1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 19"}]},{"database":"Bgee","id":"ENSG00000171051","properties":[{"key":"ExpressionPatterns","value":"Expressed in blood and 142 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"M0QZT0","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]}],"sequence":{"value":"METNSSLPTNISGGTPAVSAGYLFLDIITYLVFAVTFVL","length":39,"molWeight":4124,"crc64":"7C5664415E50048F","md5":"7E1FB8F6697AB506062815B04398BA25"},"extraAttributes":{"countByFeatureType":{"Transmembrane":1,"Non-terminal residue":1},"uniParcId":"UPI0003F47F76"}}]}