{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P55317","secondaryAccessions":["B2R9H6","B7ZAP5","Q9H2A0"],"uniProtkbId":"FOXA1_HUMAN","entryAudit":{"firstPublicDate":"1996-10-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2010-05-18","entryVersion":221,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Hepatocyte nuclear factor 3-alpha"},"shortNames":[{"value":"HNF-3-alpha"},{"value":"HNF-3A"}]},"alternativeNames":[{"fullName":{"value":"Forkhead box protein A1"}},{"fullName":{"value":"Transcription factor 3A"},"shortNames":[{"value":"TCF-3A"}]}]},"genes":[{"geneName":{"value":"FOXA1"},"synonyms":[{"value":"HNF3A"},{"value":"TCF3A"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16087863"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16331276"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18358809"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19127412"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19917725"}],"value":"Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). Proposed to play a role in translating the epigenetic signatures into cell type-specific enhancer-driven transcriptional programs. Its differential recruitment to chromatin is dependent on distribution of histone H3 methylated at 'Lys-5' (H3K4me2) in estrogen-regulated genes. Involved in the development of multiple endoderm-derived organ systems such as liver, pancreas, lung and prostate; FOXA1 and FOXA2 seem to have at least in part redundant roles (By similarity). Modulates the transcriptional activity of nuclear hormone receptors. Is involved in ESR1-mediated transcription; required for ESR1 binding to the NKX2-1 promoter in breast cancer cells; binds to the RPRM promoter and is required for the estrogen-induced repression of RPRM. Involved in regulation of apoptosis by inhibiting the expression of BCL2. Involved in cell cycle regulation by activating expression of CDKN1B, alone or in conjunction with BRCA1. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Binds DNA as a monomer (By similarity). Interacts with FOXA2. Interacts with NKX2-1. Interacts with HDAC7. Interacts with the histone H3-H4 heterodimer. Associates with nucleosomes containing histone H2A. Interacts with AR. Interacts with NR0B2 (By similarity)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P55317","intActId":"EBI-3918034"},"interactantTwo":{"uniProtKBAccession":"P10275","geneName":"AR","intActId":"EBI-608057"},"numberOfExperiments":4,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00089"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15987773"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16331276"}],"value":"Nucleus","id":"SL-0191"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["P55317-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["P55317-2"],"sequenceIds":["VSP_055094"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12234996"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15987773"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16331276"}],"value":"Highly expressed in prostate and ESR1-positive breast tumors. Overexpressed in esophageal and lung adenocarcinomas"}],"commentType":"TISSUE SPECIFICITY"},{"commentType":"WEB RESOURCE","resourceName":"Wikipedia","resourceUrl":"https://en.wikipedia.org/wiki/Hepatocyte_nuclear_factors","ftp":false,"note":"Hepatocyte nuclear factors entry"},{"commentType":"WEB RESOURCE","resourceName":"Atlas of Genetics and Cytogenetics in Oncology and Haematology","resourceUrl":"https://atlasgeneticsoncology.org/gene/44403/FOXA1","ftp":false}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":472,"modifier":"EXACT"}},"description":"Hepatocyte nuclear factor 3-alpha","featureId":"PRO_0000091792"},{"type":"DNA binding","location":{"start":{"value":169,"modifier":"EXACT"},"end":{"value":260,"modifier":"EXACT"}},"description":"Fork-head","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00089"}]},{"type":"Region","location":{"start":{"value":269,"modifier":"EXACT"},"end":{"value":392,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":273,"modifier":"EXACT"},"end":{"value":289,"modifier":"EXACT"}},"description":"Gly residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":322,"modifier":"EXACT"},"end":{"value":332,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":351,"modifier":"EXACT"},"end":{"value":366,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":307,"modifier":"EXACT"},"end":{"value":307,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Modified residue","location":{"start":{"value":331,"modifier":"EXACT"},"end":{"value":331,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":33,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"}],"featureId":"VSP_055094","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":72,"modifier":"EXACT"},"end":{"value":72,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10899756"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8652662"}],"featureId":"VAR_015183","alternativeSequence":{"originalSequence":"G","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":83,"modifier":"EXACT"},"end":{"value":83,"modifier":"EXACT"}},"description":"in dbSNP:rs7144658","featureCrossReferences":[{"database":"dbSNP","id":"rs7144658"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10899756"}],"featureId":"VAR_013457","alternativeSequence":{"originalSequence":"A","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":87,"modifier":"EXACT"},"end":{"value":87,"modifier":"EXACT"}},"description":"in dbSNP:rs35220193","featureCrossReferences":[{"database":"dbSNP","id":"rs35220193"}],"featureId":"VAR_055835","alternativeSequence":{"originalSequence":"G","alternativeSequences":["E"]}},{"type":"Natural variant","location":{"start":{"value":124,"modifier":"EXACT"},"end":{"value":124,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10899756"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8652662"}],"featureId":"VAR_015184","alternativeSequence":{"originalSequence":"M","alternativeSequences":["MM"]}},{"type":"Natural variant","location":{"start":{"value":185,"modifier":"EXACT"},"end":{"value":185,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10899756"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8652662"}],"featureId":"VAR_015185","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":448,"modifier":"EXACT"},"end":{"value":448,"modifier":"EXACT"}},"description":"in dbSNP:rs33984772","featureCrossReferences":[{"database":"dbSNP","id":"rs33984772"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10899756"}],"featureId":"VAR_013458","alternativeSequence":{"originalSequence":"S","alternativeSequences":["N"]}},{"type":"Helix","location":{"start":{"value":169,"modifier":"EXACT"},"end":{"value":171,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7VOX"}]},{"type":"Helix","location":{"start":{"value":175,"modifier":"EXACT"},"end":{"value":184,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7VOX"}]},{"type":"Helix","location":{"start":{"value":193,"modifier":"EXACT"},"end":{"value":203,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7VOX"}]},{"type":"Helix","location":{"start":{"value":205,"modifier":"EXACT"},"end":{"value":208,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7VOX"}]},{"type":"Helix","location":{"start":{"value":211,"modifier":"EXACT"},"end":{"value":224,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7VOX"}]},{"type":"Beta strand","location":{"start":{"value":228,"modifier":"EXACT"},"end":{"value":231,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7VOX"}]},{"type":"Helix","location":{"start":{"value":232,"modifier":"EXACT"},"end":{"value":234,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7VOX"}]},{"type":"Beta strand","location":{"start":{"value":243,"modifier":"EXACT"},"end":{"value":246,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7VOX"}]},{"type":"Helix","location":{"start":{"value":248,"modifier":"EXACT"},"end":{"value":250,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7VOX"}]},{"type":"Turn","location":{"start":{"value":255,"modifier":"EXACT"},"end":{"value":257,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8VG1"}]},{"type":"Beta strand","location":{"start":{"value":259,"modifier":"EXACT"},"end":{"value":261,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8VFY"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0010","category":"Molecular function","name":"Activator"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0156","category":"Molecular function","name":"Chromatin regulator"},{"id":"KW-0217","category":"Molecular function","name":"Developmental protein"},{"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0678","category":"Molecular function","name":"Repressor"},{"id":"KW-0804","category":"Biological process","name":"Transcription"},{"id":"KW-0805","category":"Biological process","name":"Transcription regulation"}],"references":[{"referenceNumber":1,"citation":{"id":"8652662","citationType":"journal article","authors":["Bingle C.D.","Gowan S."],"citationCrossReferences":[{"database":"PubMed","id":"8652662"},{"database":"DOI","id":"10.1016/0167-4781(96)00058-9"}],"title":"Molecular cloning of the forkhead transcription factor HNF-3 alpha from a human pulmonary adenocarcinoma cell line.","publicationDate":"1996","journal":"Biochim. Biophys. Acta","firstPage":"17","lastPage":"20","volume":"1307"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)","VARIANTS ALA-72; MET-124 INS AND ARG-185"],"referenceComments":[{"value":"Lung","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"10899756","citationType":"journal article","authors":["Navas M.A.","Vaisse C.","Boger S.","Heimesaat M.","Kollee L.A.","Stoffel M."],"citationCrossReferences":[{"database":"PubMed","id":"10899756"},{"database":"DOI","id":"10.1159/000022943"}],"title":"The human HNF-3 genes: cloning, partial sequence and mutation screening in patients with impaired glucose homeostasis.","publicationDate":"2000","journal":"Hum. Hered.","firstPage":"370","lastPage":"381","volume":"50"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]","VARIANTS ALA-72; THR-83; MET-124 INS; ARG-185 AND ASN-448"]},{"referenceNumber":3,"citation":{"id":"CI-6C2DEQQM4NCAH","citationType":"submission","authors":["Yu L.","Takeda J."],"title":"Genetic variation in the HNF-3alpha gene.","publicationDate":"SEP-2000","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":4,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)"],"referenceComments":[{"value":"Mammary gland","type":"TISSUE"},{"value":"Trachea","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"12508121","citationType":"journal article","authors":["Heilig R.","Eckenberg R.","Petit J.-L.","Fonknechten N.","Da Silva C.","Cattolico L.","Levy M.","Barbe V.","De Berardinis V.","Ureta-Vidal A.","Pelletier E.","Vico V.","Anthouard V.","Rowen L.","Madan A.","Qin S.","Sun H.","Du H.","Pepin K.","Artiguenave F.","Robert C.","Cruaud C.","Bruels T.","Jaillon O.","Friedlander L.","Samson G.","Brottier P.","Cure S.","Segurens B.","Aniere F.","Samain S.","Crespeau H.","Abbasi N.","Aiach N.","Boscus D.","Dickhoff R.","Dors M.","Dubois I.","Friedman C.","Gouyvenoux M.","James R.","Madan A.","Mairey-Estrada B.","Mangenot S.","Martins N.","Menard M.","Oztas S.","Ratcliffe A.","Shaffer T.","Trask B.","Vacherie B.","Bellemere C.","Belser C.","Besnard-Gonnet M.","Bartol-Mavel D.","Boutard M.","Briez-Silla S.","Combette S.","Dufosse-Laurent V.","Ferron C.","Lechaplais C.","Louesse C.","Muselet D.","Magdelenat G.","Pateau E.","Petit E.","Sirvain-Trukniewicz P.","Trybou A.","Vega-Czarny N.","Bataille E.","Bluet E.","Bordelais I.","Dubois M.","Dumont C.","Guerin T.","Haffray S.","Hammadi R.","Muanga J.","Pellouin V.","Robert D.","Wunderle E.","Gauguet G.","Roy A.","Sainte-Marthe L.","Verdier J.","Verdier-Discala C.","Hillier L.W.","Fulton L.","McPherson J.","Matsuda F.","Wilson R.","Scarpelli C.","Gyapay G.","Wincker P.","Saurin W.","Quetier F.","Waterston R.","Hood L.","Weissenbach J."],"citationCrossReferences":[{"database":"PubMed","id":"12508121"},{"database":"DOI","id":"10.1038/nature01348"}],"title":"The DNA sequence and analysis of human chromosome 14.","publicationDate":"2003","journal":"Nature","firstPage":"601","lastPage":"607","volume":"421"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":6,"citation":{"id":"CI-5GBD0VIIJ7C63","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"SEP-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":7,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"Testis","type":"TISSUE"}]},{"referenceNumber":8,"citation":{"id":"12234996","citationType":"journal article","authors":["Lin L.","Miller C.T.","Contreras J.I.","Prescott M.S.","Dagenais S.L.","Wu R.","Yee J.","Orringer M.B.","Misek D.E.","Hanash S.M.","Glover T.W.","Beer D.G."],"citationCrossReferences":[{"database":"PubMed","id":"12234996"}],"title":"The hepatocyte nuclear factor 3 alpha gene, HNF3alpha (FOXA1), on chromosome band 14q13 is amplified and overexpressed in esophageal and lung adenocarcinomas.","publicationDate":"2002","journal":"Cancer Res.","firstPage":"5273","lastPage":"5279","volume":"62"},"referencePositions":["TISSUE SPECIFICITY"]},{"referenceNumber":9,"citation":{"id":"15987773","citationType":"journal article","authors":["Gao N.","Ishii K.","Mirosevich J.","Kuwajima S.","Oppenheimer S.R.","Roberts R.L.","Jiang M.","Yu X.","Shappell S.B.","Caprioli R.M.","Stoffel M.","Hayward S.W.","Matusik R.J."],"citationCrossReferences":[{"database":"PubMed","id":"15987773"},{"database":"DOI","id":"10.1242/dev.01917"}],"title":"Forkhead box A1 regulates prostate ductal morphogenesis and promotes epithelial cell maturation.","publicationDate":"2005","journal":"Development","firstPage":"3431","lastPage":"3443","volume":"132"},"referencePositions":["TISSUE SPECIFICITY","SUBCELLULAR LOCATION"]},{"referenceNumber":10,"citation":{"id":"16087863","citationType":"journal article","authors":["Laganiere J.","Deblois G.","Lefebvre C.","Bataille A.R.","Robert F.","Giguere V."],"citationCrossReferences":[{"database":"PubMed","id":"16087863"},{"database":"DOI","id":"10.1073/pnas.0505575102"}],"title":"Location analysis of estrogen receptor alpha target promoters reveals that FOXA1 defines a domain of the estrogen response.","publicationDate":"2005","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"11651","lastPage":"11656","volume":"102"},"referencePositions":["FUNCTION"]},{"referenceNumber":11,"citation":{"id":"16331276","citationType":"journal article","authors":["Williamson E.A.","Wolf I.","O'Kelly J.","Bose S.","Tanosaki S.","Koeffler H.P."],"citationCrossReferences":[{"database":"PubMed","id":"16331276"},{"database":"DOI","id":"10.1038/sj.onc.1209170"}],"title":"BRCA1 and FOXA1 proteins coregulate the expression of the cell cycle-dependent kinase inhibitor p27(Kip1).","publicationDate":"2006","journal":"Oncogene","firstPage":"1391","lastPage":"1399","volume":"25"},"referencePositions":["FUNCTION IN CELL CYCLE REGULATION","SUBCELLULAR LOCATION","TISSUE SPECIFICITY"]},{"referenceNumber":12,"citation":{"id":"17220277","citationType":"journal article","authors":["Minoo P.","Hu L.","Xing Y.","Zhu N.L.","Chen H.","Li M.","Borok Z.","Li C."],"citationCrossReferences":[{"database":"PubMed","id":"17220277"},{"database":"DOI","id":"10.1128/mcb.01133-06"}],"title":"Physical and functional interactions between homeodomain NKX2.1 and winged helix/forkhead FOXA1 in lung epithelial cells.","publicationDate":"2007","journal":"Mol. Cell. Biol.","firstPage":"2155","lastPage":"2165","volume":"27"},"referencePositions":["INTERACTION WITH NKX2-1"]},{"referenceNumber":13,"citation":{"id":"18358809","citationType":"journal article","authors":["Lupien M.","Eeckhoute J.","Meyer C.A.","Wang Q.","Zhang Y.","Li W.","Carroll J.S.","Liu X.S.","Brown M."],"citationCrossReferences":[{"database":"PubMed","id":"18358809"},{"database":"DOI","id":"10.1016/j.cell.2008.01.018"}],"title":"FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcription.","publicationDate":"2008","journal":"Cell","firstPage":"958","lastPage":"970","volume":"132"},"referencePositions":["FUNCTION IN CELL TYPE-SPECIFIC TRANSCRIPTION","DIFFERENTIAL RECRUITMENT TO CHROMATIN"]},{"referenceNumber":14,"citation":{"id":"19127412","citationType":"journal article","authors":["Song L.","Wei X.","Zhang B.","Luo X.","Liu J.","Feng Y.","Xiao X."],"citationCrossReferences":[{"database":"PubMed","id":"19127412"},{"database":"DOI","id":"10.1007/s12192-008-0095-4"}],"title":"Role of Foxa1 in regulation of bcl2 expression during oxidative-stress-induced apoptosis in A549 type II pneumocytes.","publicationDate":"2009","journal":"Cell Stress Chaperones","firstPage":"417","lastPage":"425","volume":"14"},"referencePositions":["FUNCTION IN REGULATION OF APOPTOSIS"]},{"referenceNumber":15,"citation":{"id":"19919681","citationType":"journal article","authors":["Motallebipour M.","Ameur A.","Reddy Bysani M.S.","Patra K.","Wallerman O.","Mangion J.","Barker M.A.","McKernan K.J.","Komorowski J.","Wadelius C."],"citationCrossReferences":[{"database":"PubMed","id":"19919681"},{"database":"DOI","id":"10.1186/gb-2009-10-11-r129"}],"title":"Differential binding and co-binding pattern of FOXA1 and FOXA3 and their relation to H3K4me3 in HepG2 cells revealed by ChIP-seq.","publicationDate":"2009","journal":"Genome Biol.","firstPage":"R129.0","lastPage":"R129.0","volume":"10"},"referencePositions":["INTERACTION WITH FOXA2"]},{"referenceNumber":16,"citation":{"id":"19917725","citationType":"journal article","authors":["Malik S.","Jiang S.","Garee J.P.","Verdin E.","Lee A.V.","O'Malley B.W.","Zhang M.","Belaguli N.S.","Oesterreich S."],"citationCrossReferences":[{"database":"PubMed","id":"19917725"},{"database":"DOI","id":"10.1128/mcb.00907-09"}],"title":"Histone deacetylase 7 and FoxA1 in estrogen-mediated repression of RPRM.","publicationDate":"2010","journal":"Mol. Cell. Biol.","firstPage":"399","lastPage":"412","volume":"30"},"referencePositions":["FUNCTION IN ESR1-MEDIATED TRANSCRIPTION REPRESSION","DIFFERENTIAL RECRUITMENT TO CHROMATIN","INTERACTION WITH HDAC7"]},{"referenceNumber":17,"citation":{"id":"20068231","citationType":"journal article","authors":["Olsen J.V.","Vermeulen M.","Santamaria A.","Kumar C.","Miller M.L.","Jensen L.J.","Gnad F.","Cox J.","Jensen T.S.","Nigg E.A.","Brunak S.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"20068231"},{"database":"DOI","id":"10.1126/scisignal.2000475"}],"title":"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.","publicationDate":"2010","journal":"Sci. Signal.","firstPage":"RA3","lastPage":"RA3","volume":"3"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":18,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"},{"database":"DOI","id":"10.1021/pr300630k"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-307","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"},{"value":"Erythroleukemia","type":"TISSUE"}]},{"referenceNumber":19,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-307 AND SER-331","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"U39840","properties":[{"key":"ProteinId","value":"AAB06493.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF176112","properties":[{"key":"ProteinId","value":"AAD51979.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF176111","properties":[{"key":"ProteinId","value":"AAD51979.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF303743","properties":[{"key":"ProteinId","value":"AAG40847.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF303742","properties":[{"key":"ProteinId","value":"AAG40847.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AK313785","properties":[{"key":"ProteinId","value":"BAG36523.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK316360","properties":[{"key":"ProteinId","value":"BAH14731.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AL121790","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471078","properties":[{"key":"ProteinId","value":"EAW65844.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC033890","properties":[{"key":"ProteinId","value":"AAH33890.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS9665.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P55317-1"},{"database":"PIR","id":"S70357","properties":[{"key":"EntryName","value":"S70357"}]},{"database":"RefSeq","id":"NP_004487.2","properties":[{"key":"NucleotideSequenceId","value":"NM_004496.5"}],"isoformId":"P55317-1"},{"database":"PDB","id":"7VOX","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.10 A"},{"key":"Chains","value":"A/B/C/H=168-264"}]},{"database":"PDB","id":"8VFY","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.89 A"},{"key":"Chains","value":"O=1-472"}]},{"database":"PDB","id":"8VFZ","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.10 A"},{"key":"Chains","value":"O/P=1-472"}]},{"database":"PDB","id":"8VG1","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.48 A"},{"key":"Chains","value":"O=1-472"}]},{"database":"PDB","id":"8VG2","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.04 A"},{"key":"Chains","value":"O=1-472"}]},{"database":"PDBsum","id":"7VOX","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8VFY","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8VFZ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8VG1","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8VG2","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"P55317","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-43194","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-43195","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-43197","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-43198","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P55317","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"109411","properties":[{"key":"Interactions","value":"524"}]},{"database":"CORUM","id":"P55317","properties":[{"key":"Description","value":"-"}]},{"database":"DIP","id":"DIP-57138N","properties":[{"key":"Description","value":"-"}]},{"database":"ELM","id":"P55317","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P55317","properties":[{"key":"Number of interactors","value":"4980"}]},{"database":"IntAct","id":"P55317","properties":[{"key":"Interactions","value":"54"}]},{"database":"MINT","id":"P55317","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-FOXA1","properties":[{"key":"Evidences","value":"11 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000250448","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"P55317","properties":[{"key":"glycosylation","value":"11 sites, 1 O-linked glycan (11 sites)"}]},{"database":"iPTMnet","id":"P55317","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"P55317","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"P55317","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"FOXA1","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"296434509","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"P55317","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"P55317","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000250448","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P55317","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"56845","properties":[{"key":"Description","value":"-"}],"isoformId":"P55317-1"},{"database":"ProteomicsDB","id":"7076","properties":[{"key":"Description","value":"-"}]},{"database":"Pumba","id":"P55317","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"23304","properties":[{"key":"antibodies","value":"1532 antibodies from 46 providers"}]},{"database":"DNASU","id":"3169","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000250448.5","properties":[{"key":"ProteinId","value":"ENSP00000250448.3"},{"key":"GeneId","value":"ENSG00000129514.8"}],"isoformId":"P55317-1"},{"database":"GeneID","id":"3169","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:3169","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000250448.5","properties":[{"key":"ProteinId","value":"ENSP00000250448.3"},{"key":"RefSeqNucleotideId","value":"NM_004496.5"},{"key":"RefSeqProteinId","value":"NP_004487.2"}]},{"database":"UCSC","id":"uc001wuf.5","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"P55317-1"},{"database":"AGR","id":"HGNC:5021","properties":[{"key":"Description","value":"-"}]},{"database":"CIViC","id":"3169","properties":[{"key":"Number of evidences","value":"1 evidence item across 1 molecular profile"}]},{"database":"ClinPGx","id":"PA201090","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"3169","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"3169","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"FOXA1","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:5021","properties":[{"key":"GeneName","value":"FOXA1"}]},{"database":"HPA","id":"ENSG00000129514","properties":[{"key":"ExpressionPatterns","value":"Tissue enhanced (prostate)"}]},{"database":"MalaCards","id":"FOXA1","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"602294","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000129514","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000129514","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG3563","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000162043","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_027910_4_1_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P55317","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"WSSYYTD","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"5954824at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"P55317","properties":[{"key":"Number of GO annotations","value":"5 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"P55317","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"P55317","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-9018519","properties":[{"key":"PathwayName","value":"Estrogen-dependent gene expression"}]},{"database":"Reactome","id":"R-HSA-9796292","properties":[{"key":"PathwayName","value":"Formation of axial mesoderm"}]},{"database":"SignaLink","id":"P55317","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"P55317","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000129514","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"3169","properties":[{"key":"hits","value":"64 hits in 1194 CRISPR screens"}]},{"database":"ChiTaRS","id":"FOXA1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GeneWiki","id":"FOXA1","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"3169","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"P55317","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:P55317","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 14"}]},{"database":"RNAct","id":"P55317","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000129514","properties":[{"key":"ExpressionPatterns","value":"Expressed in endometrium epithelium and 106 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"P55317","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0000785","properties":[{"key":"GoTerm","value":"C:chromatin"},{"key":"GoEvidenceType","value":"ISA:NTNU_SB"}]},{"database":"GO","id":"GO:0001650","properties":[{"key":"GoTerm","value":"C:fibrillar center"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005902","properties":[{"key":"GoTerm","value":"C:microvillus"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"9931457"}]},{"database":"GO","id":"GO:0003682","properties":[{"key":"GoTerm","value":"F:chromatin binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0003677","properties":[{"key":"GoTerm","value":"F:DNA binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"9931457"}]},{"database":"GO","id":"GO:0001228","properties":[{"key":"GoTerm","value":"F:DNA-binding transcription activator activity, RNA polymerase II-specific"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0003700","properties":[{"key":"GoTerm","value":"F:DNA-binding transcription factor activity"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"8652662"}]},{"database":"GO","id":"GO:0000981","properties":[{"key":"GoTerm","value":"F:DNA-binding transcription factor activity, RNA polymerase II-specific"},{"key":"GoEvidenceType","value":"ISA:NTNU_SB"}]},{"database":"GO","id":"GO:0019904","properties":[{"key":"GoTerm","value":"F:protein domain specific binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0000978","properties":[{"key":"GoTerm","value":"F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"25802280"}]},{"database":"GO","id":"GO:1990837","properties":[{"key":"GoTerm","value":"F:sequence-specific double-stranded DNA binding"},{"key":"GoEvidenceType","value":"IDA:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"28473536"}]},{"database":"GO","id":"GO:0000976","properties":[{"key":"GoTerm","value":"F:transcription cis-regulatory region binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16087863"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16331276"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19127412"}]},{"database":"GO","id":"GO:0009653","properties":[{"key":"GoTerm","value":"P:anatomical structure morphogenesis"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0030154","properties":[{"key":"GoTerm","value":"P:cell differentiation"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0006338","properties":[{"key":"GoTerm","value":"P:chromatin remodeling"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0071542","properties":[{"key":"GoTerm","value":"P:dopaminergic neuron differentiation"},{"key":"GoEvidenceType","value":"TAS:ParkinsonsUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"24431302"}]},{"database":"GO","id":"GO:0010719","properties":[{"key":"GoTerm","value":"P:negative regulation of epithelial to mesenchymal transition"},{"key":"GoEvidenceType","value":"IMP:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"20160041"}]},{"database":"GO","id":"GO:0043065","properties":[{"key":"GoTerm","value":"P:positive regulation of apoptotic process"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19127412"}]},{"database":"GO","id":"GO:2000049","properties":[{"key":"GoTerm","value":"P:positive regulation of cell-cell adhesion mediated by cadherin"},{"key":"GoEvidenceType","value":"IC:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"20160041"}]},{"database":"GO","id":"GO:0033148","properties":[{"key":"GoTerm","value":"P:positive regulation of intracellular estrogen receptor signaling pathway"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"16087863"}]},{"database":"GO","id":"GO:1902895","properties":[{"key":"GoTerm","value":"P:positive regulation of miRNA transcription"},{"key":"GoEvidenceType","value":"IC:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"25802280"}]},{"database":"GO","id":"GO:0045931","properties":[{"key":"GoTerm","value":"P:positive regulation of mitotic cell cycle"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"16087863"}]},{"database":"GO","id":"GO:0045944","properties":[{"key":"GoTerm","value":"P:positive regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16331276"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19127412"}]},{"database":"GO","id":"GO:0006357","properties":[{"key":"GoTerm","value":"P:regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0032355","properties":[{"key":"GoTerm","value":"P:response to estradiol"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16087863"}]},{"database":"CDD","id":"cd20038","properties":[{"key":"EntryName","value":"FH_FOXA1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.10.10:FF:000042","properties":[{"key":"EntryName","value":"hepatocyte nuclear factor 3-beta"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.10.10","properties":[{"key":"EntryName","value":"Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR013638","properties":[{"key":"EntryName","value":"Fork-head_N"}]},{"database":"InterPro","id":"IPR001766","properties":[{"key":"EntryName","value":"Fork_head_dom"}]},{"database":"InterPro","id":"IPR018533","properties":[{"key":"EntryName","value":"Forkhead_box_C"}]},{"database":"InterPro","id":"IPR050211","properties":[{"key":"EntryName","value":"FOX_domain-containing"}]},{"database":"InterPro","id":"IPR018122","properties":[{"key":"EntryName","value":"TF_fork_head_CS_1"}]},{"database":"InterPro","id":"IPR030456","properties":[{"key":"EntryName","value":"TF_fork_head_CS_2"}]},{"database":"InterPro","id":"IPR036388","properties":[{"key":"EntryName","value":"WH-like_DNA-bd_sf"}]},{"database":"InterPro","id":"IPR036390","properties":[{"key":"EntryName","value":"WH_DNA-bd_sf"}]},{"database":"PANTHER","id":"PTHR11829","properties":[{"key":"EntryName","value":"FORKHEAD BOX PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11829:SF195","properties":[{"key":"EntryName","value":"HEPATOCYTE NUCLEAR FACTOR 3-ALPHA"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00250","properties":[{"key":"EntryName","value":"Forkhead"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08430","properties":[{"key":"EntryName","value":"Forkhead_N"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF09354","properties":[{"key":"EntryName","value":"HNF_C"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00053","properties":[{"key":"EntryName","value":"FORKHEAD"}]},{"database":"SMART","id":"SM00339","properties":[{"key":"EntryName","value":"FH"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF46785","properties":[{"key":"EntryName","value":"Winged helix' DNA-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00657","properties":[{"key":"EntryName","value":"FORK_HEAD_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00658","properties":[{"key":"EntryName","value":"FORK_HEAD_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50039","properties":[{"key":"EntryName","value":"FORK_HEAD_3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MLGTVKMEGHETSDWNSYYADTQEAYSSVPVSNMNSGLGSMNSMNTYMTMNTMTTSGNMTPASFNMSYANPGLGAGLSPGAVAGMPGGSAGAMNSMTAAGVTAMGTALSPSGMGAMGAQQAASMNGLGPYAAAMNPCMSPMAYAPSNLGRSRAGGGGDAKTFKRSYPHAKPPYSYISLITMAIQQAPSKMLTLSEIYQWIMDLFPYYRQNQQRWQNSIRHSLSFNDCFVKVARSPDKPGKGSYWTLHPDSGNMFENGCYLRRQKRFKCEKQPGAGGGGGSGSGGSGAKGGPESRKDPSGASNPSADSPLHRGVHGKTGQLEGAPAPGPAASPQTLDHSGATATGGASELKTPASSTAPPISSGPGALASVPASHPAHGLAPHESQLHLKGDPHYSFNHPFSINNLMSSSEQQHKLDFKAYEQALQYSPYGSTLPASLPLGSASVTTRSPIEPSALEPAYYQGVYSRPVLNTS","length":472,"molWeight":49148,"crc64":"B2489523459EEB4C","md5":"1FC05D46BC830F1B945BF35179603BBF"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"INTERACTION":1,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":2,"TISSUE SPECIFICITY":1,"WEB RESOURCE":2},"countByFeatureType":{"Chain":1,"DNA binding":1,"Region":1,"Compositional bias":3,"Modified residue":2,"Alternative sequence":1,"Natural variant":6,"Helix":7,"Beta strand":3,"Turn":1},"uniParcId":"UPI000013CCBA"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"G3V4B9","uniProtkbId":"G3V4B9_HUMAN","entryAudit":{"firstPublicDate":"2011-11-16","lastAnnotationUpdateDate":"2026-06-10","lastSequenceUpdateDate":"2011-11-16","entryVersion":64,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000451704.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000451704.1"}],"value":"Forkhead box A1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000451704.1"}],"value":"FOXA1"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000451704.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"12508121","citationType":"journal article","authors":["Heilig R.","Eckenberg R.","Petit J.L.","Fonknechten N.","Da Silva C.","Cattolico L.","Levy M.","Barbe V.","de Berardinis V.","Ureta-Vidal A.","Pelletier E.","Vico V.","Anthouard V.","Rowen L.","Madan A.","Qin S.","Sun H.","Du H.","Pepin K.","Artiguenave F.","Robert C.","Cruaud C.","Bruls T.","Jaillon O.","Friedlander L.","Samson G.","Brottier P.","Cure S.","Segurens B.","Aniere F.","Samain S.","Crespeau H.","Abbasi N.","Aiach N.","Boscus D.","Dickhoff R.","Dors M.","Dubois I.","Friedman C.","Gouyvenoux M.","James R.","Madan A.","Mairey-Estrada B.","Mangenot S.","Martins N.","Menard M.","Oztas S.","Ratcliffe A.","Shaffer T.","Trask B.","Vacherie B.","Bellemere C.","Belser C.","Besnard-Gonnet M.","Bartol-Mavel D.","Boutard M.","Briez-Silla S.","Combette S.","Dufosse-Laurent V.","Ferron C.","Lechaplais C.","Louesse C.","Muselet D.","Magdelenat G.","Pateau E.","Petit E.","Sirvain-Trukniewicz P.","Trybou A.","Vega-Czarny N.","Bataille E.","Bluet E.","Bordelais I.","Dubois M.","Dumont C.","Guerin T.","Haffray S.","Hammadi R.","Muanga J.","Pellouin V.","Robert D.","Wunderle E.","Gauguet G.","Roy A.","Sainte-Marthe L.","Verdier J.","Verdier-Discala C.","Hillier L.","Fulton L.","McPherson J.","Matsuda F.","Wilson R.","Scarpelli C.","Gyapay G.","Wincker P.","Saurin W.","Quetier F.","Waterston R.","Hood L.","Weissenbach J."],"citationCrossReferences":[{"database":"PubMed","id":"12508121"},{"database":"DOI","id":"10.1038/nature01348"}],"title":"The DNA sequence and analysis of human chromosome 14.","publicationDate":"2003","journal":"Nature","firstPage":"601","lastPage":"607","volume":"421"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000451704.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000451704.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000451704.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL121790","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"G3V4B9","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000553751.1","properties":[{"key":"ProteinId","value":"ENSP00000451704.1"},{"key":"GeneId","value":"ENSG00000129514.8"}]},{"database":"UCSC","id":"uc059ayn.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:5021","properties":[{"key":"GeneName","value":"FOXA1"}]},{"database":"OpenTargets","id":"ENSG00000129514","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000129514","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000162043","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_3359417_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"5954824at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"FOXA1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 14"}]},{"database":"Bgee","id":"ENSG00000129514","properties":[{"key":"ExpressionPatterns","value":"Expressed in endometrium epithelium and 106 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"G3V4B9","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]}],"sequence":{"value":"MLGTVKMEGHETSDWNSYYADTQELAITLQKFNYHY","length":36,"molWeight":4286,"crc64":"0C76CE548DD7F775","md5":"D804DC0284E4DCF5BFB36A42267E90D5"},"extraAttributes":{"uniParcId":"UPI00021CF1B2"}}]}