{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P21333","secondaryAccessions":["E9KL45","Q5HY53","Q5HY55","Q8NF52"],"uniProtkbId":"FLNA_HUMAN","entryAudit":{"firstPublicDate":"1991-05-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2007-01-23","entryVersion":280,"sequenceVersion":4},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Filamin-A"},"shortNames":[{"value":"FLN-A"}]},"alternativeNames":[{"fullName":{"value":"Actin-binding protein 280"},"shortNames":[{"value":"ABP-280"}]},{"fullName":{"value":"Alpha-filamin"}},{"fullName":{"value":"Endothelial actin-binding protein"}},{"fullName":{"value":"Filamin-1"}},{"fullName":{"value":"Non-muscle filamin"}}]},"genes":[{"geneName":{"value":"FLNA"},"synonyms":[{"value":"FLN"},{"value":"FLN1"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8BTM8"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22121117"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25358863"}],"value":"Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8BTM8"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11102480"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11739414"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12393796"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15684392"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16076904"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16291724"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16862148"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18322202"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18556573"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19828450"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19923718"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20713593"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21228480"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21524097"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22121117"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23890175"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25358863"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25666618"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26460884"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9437013"}],"value":"Homodimer. Interacts with PDLIM2 (By similarity). Interacts with RFLNA and RFLNB (By similarity). Interacts with FCGR1A, FLNB, FURIN, HSPB7, INPPL1, KCND2, MYOT, MYOZ1, ARHGAP24, PSEN1, PSEN2 and ECSCR. Also interacts with various other binding partners in addition to filamentous actin. Interacts (via N-terminus) with MIS18BP1 (via N-terminus). Interacts (via N-terminus) with TAF1B. Interacts with TMEM67 (via C-terminus) and MKS1. Interacts (via actin-binding domain) with MICALL2 (via CH domain). Interacts (via filamin repeat 5) with SYK; docks SYK to the plasma membrane (PubMed:20713593). Interacts (via filamin repeats 19 and 21) with DRD3; increased PKA-mediated phosphorylation at Ser-2152. Interacts (via filamin repeat 21) with MAS1, AGTR1 and ADRA1D; increases PKA-mediated phosphorylation of FLNA at Ser-2152 (PubMed:26460884). Interacts (via filamin repeats 4, 9, 12, 17, 19, 21, and 23) with GP1BA (high affinity), ITGB7, ITGB2 and FBLIM1 (PubMed:19828450, PubMed:21524097, PubMed:25666618). Interacts with CEACAM1 (via cytoplasmic domain); inhibits cell migration and cell scattering by interfering with the interaction between FLNA and RALA (PubMed:16291724). Interacts with FOXC1 (PubMed:15684392). Interacts (via calponin-homology (CH) domain 1 and filamin repeat 24) with CRMP1; the interaction alters FLNA ternary structure and thus promotes FLNA dissociation from F-actin (PubMed:25358863). Interacts with DPYSL3/CRMP3 and DPYSL4/CRMP4 (PubMed:25358863)"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11807098"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30990684"}],"value":"Interacts with integrin ITGB1 isoform 1/beta-1A and isoform 5/beta-1D (PubMed:11807098). Interacts with LUZP1; the interaction is not necessary for colocalization of LUZP1 with F-actin (PubMed:30990684)"}],"commentType":"SUBUNIT","molecule":"Isoform 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Following SEMA3A stimulation of DRG neurons, colocalizes with F-actin (By similarity). 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