{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P02675","secondaryAccessions":["A0JLR9","B2R7G3","Q32Q65","Q3KPF2"],"uniProtkbId":"FIBB_HUMAN","entryAudit":{"firstPublicDate":"1986-07-21","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1993-07-01","entryVersion":263,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Fibrinogen beta chain"}},"contains":[{"recommendedName":{"fullName":{"value":"Fibrinopeptide B"}}},{"recommendedName":{"fullName":{"value":"Fibrinogen beta chain"}}}],"flag":"Precursor"},"genes":[{"geneName":{"value":"FGB"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"E9PV24"}],"value":"Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10074346"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19296670"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9333233"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9628725"}],"value":"Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P02675","intActId":"EBI-1034445"},"interactantTwo":{"uniProtKBAccession":"P27958","chainId":"PRO_0000037566","intActId":"EBI-6377335"},"numberOfExperiments":4,"organismDiffer":true}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10074346"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19296670"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9628725"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10074346"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19296670"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9628725"}],"value":"Detected in blood plasma (at protein level)"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10074346"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19296670"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9628725"}],"value":"A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to the coiled coil structure"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2143188"}],"value":"Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers"}],"commentType":"PTM"},{"commentType":"DISEASE","disease":{"diseaseId":"Congenital afibrinogenemia","diseaseAccession":"DI-01387","acronym":"CAFBN","description":"Rare autosomal recessive disorder is characterized by bleeding that varies from mild to severe and by complete absence or extremely low levels of plasma and platelet fibrinogen.","diseaseCrossReference":{"database":"MIM","id":"202400"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10666208"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11468164"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15070683"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25427968"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry. Patients with congenital fibrinogen abnormalities can manifest different clinical pictures. Some cases are clinically silent, some show a tendency toward bleeding and some show a predisposition for thrombosis with or without bleeding"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"Dysfibrinogenemia, congenital","diseaseAccession":"DI-04218","acronym":"DYSFIBRIN","description":"A disorder characterized by qualitative abnormalities (dysfibrinogenemia) of the circulating fibrinogen. Affected individuals are frequently asymptomatic, but some patients have bleeding diathesis, thromboembolic complications, or both. In some cases, dysfibrinogenemia is associated with low circulating fibrinogen levels (hypodysfibrinogenemia).","diseaseCrossReference":{"database":"MIM","id":"616004"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1634610"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Miscellaneous discrepancy","sequence":"AAH07030.1","note":"Contaminating sequence. Potential poly-A sequence.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"WEB RESOURCE","resourceName":"Wikipedia","resourceUrl":"https://en.wikipedia.org/wiki/Fibrinogen","ftp":false,"note":"Fibrinogen entry"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":30,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"420779"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"936108"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.11"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.13"}]},{"type":"Peptide","location":{"start":{"value":31,"modifier":"EXACT"},"end":{"value":44,"modifier":"EXACT"}},"description":"Fibrinopeptide B","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12665801"}],"featureId":"PRO_0000009070"},{"type":"Chain","location":{"start":{"value":45,"modifier":"EXACT"},"end":{"value":491,"modifier":"EXACT"}},"description":"Fibrinogen beta chain","featureId":"PRO_0000009071"},{"type":"Domain","location":{"start":{"value":232,"modifier":"EXACT"},"end":{"value":488,"modifier":"EXACT"}},"description":"Fibrinogen C-terminal","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00739"}]},{"type":"Region","location":{"start":{"value":44,"modifier":"EXACT"},"end":{"value":75,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":45,"modifier":"EXACT"},"end":{"value":47,"modifier":"EXACT"}},"description":"Beta-chain polymerization, binding distal domain of another fibrin"},{"type":"Coiled coil","location":{"start":{"value":157,"modifier":"EXACT"},"end":{"value":222,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"10074346"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"19296670"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"9628725"}]},{"type":"Compositional bias","location":{"start":{"value":47,"modifier":"EXACT"},"end":{"value":57,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Site","location":{"start":{"value":44,"modifier":"EXACT"},"end":{"value":45,"modifier":"EXACT"}},"description":"Cleavage; by thrombin; to release fibrinopeptide B"},{"type":"Site","location":{"start":{"value":152,"modifier":"EXACT"},"end":{"value":153,"modifier":"EXACT"}},"description":"Cleavage; by plasmin; to break down fibrin clots"},{"type":"Site","location":{"start":{"value":160,"modifier":"EXACT"},"end":{"value":161,"modifier":"EXACT"}},"description":"Cleavage; by hementin; to prevent blood coagulation"},{"type":"Site","location":{"start":{"value":163,"modifier":"EXACT"},"end":{"value":164,"modifier":"EXACT"}},"description":"Cleavage; by plasmin; to break down fibrin clots"},{"type":"Modified residue","location":{"start":{"value":31,"modifier":"EXACT"},"end":{"value":31,"modifier":"EXACT"}},"description":"Pyrrolidone carboxylic acid","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"420779"}]},{"type":"Glycosylation","location":{"start":{"value":394,"modifier":"EXACT"},"end":{"value":394,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10074346"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16263699"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16335952"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19159218"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9628725"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.11"}],"featureId":""},{"type":"Disulfide bond","location":{"start":{"value":95,"modifier":"EXACT"},"end":{"value":95,"modifier":"EXACT"}},"description":"Interchain (with C-55 in alpha chain)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19296670"}]},{"type":"Disulfide bond","location":{"start":{"value":106,"modifier":"EXACT"},"end":{"value":106,"modifier":"EXACT"}},"description":"Interchain (with C-68 in alpha chain)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19296670"}]},{"type":"Disulfide bond","location":{"start":{"value":110,"modifier":"EXACT"},"end":{"value":110,"modifier":"EXACT"}},"description":"Interchain (with C-45 in gamma chain)","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"6575689"}]},{"type":"Disulfide bond","location":{"start":{"value":223,"modifier":"EXACT"},"end":{"value":223,"modifier":"EXACT"}},"description":"Interchain (with C-184 in alpha chain)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10074346"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19296670"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9333233"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9628725"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"1FZC"}]},{"type":"Disulfide bond","location":{"start":{"value":227,"modifier":"EXACT"},"end":{"value":227,"modifier":"EXACT"}},"description":"Interchain (with C-161 in gamma chain)"},{"type":"Disulfide bond","location":{"start":{"value":231,"modifier":"EXACT"},"end":{"value":316,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10074346"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19296670"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9333233"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9628725"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"1FZC"}]},{"type":"Disulfide bond","location":{"start":{"value":241,"modifier":"EXACT"},"end":{"value":270,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10074346"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19296670"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9333233"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9628725"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"1FZC"}]},{"type":"Disulfide bond","location":{"start":{"value":424,"modifier":"EXACT"},"end":{"value":437,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10074346"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19296670"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9333233"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9628725"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"1FZC"}]},{"type":"Natural variant","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":2,"modifier":"EXACT"}},"description":"in dbSNP:rs6053","featureCrossReferences":[{"database":"dbSNP","id":"rs6053"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10391209"}],"featureId":"VAR_014169","alternativeSequence":{"originalSequence":"K","alternativeSequences":["E"]}},{"type":"Natural variant","location":{"start":{"value":39,"modifier":"EXACT"},"end":{"value":102,"modifier":"EXACT"}},"description":"in New York-1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"3156856"}],"featureId":"VAR_002402","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":44,"modifier":"EXACT"},"end":{"value":44,"modifier":"EXACT"}},"description":"in Christchurch-2, Seattle-1 and Ijmuiden; dbSNP:rs121909616","featureCrossReferences":[{"database":"dbSNP","id":"rs121909616"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1565641"}],"featureId":"VAR_002403","alternativeSequence":{"originalSequence":"R","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":45,"modifier":"EXACT"},"end":{"value":45,"modifier":"EXACT"}},"description":"in Ise","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2018836"}],"featureId":"VAR_002404","alternativeSequence":{"originalSequence":"G","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":74,"modifier":"EXACT"},"end":{"value":74,"modifier":"EXACT"}},"description":"in Nijmegen; dbSNP:rs121909619","featureCrossReferences":[{"database":"dbSNP","id":"rs121909619"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1565641"}],"featureId":"VAR_002405","alternativeSequence":{"originalSequence":"R","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":95,"modifier":"EXACT"},"end":{"value":95,"modifier":"EXACT"}},"description":"in CAFBN; hypofibrinogenemia; heterozygous; decreased fibrinogen complex assembly; no effect on fibrinogen complex secretion","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25427968"}],"featureId":"VAR_072724","alternativeSequence":{"originalSequence":"C","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":98,"modifier":"EXACT"},"end":{"value":98,"modifier":"EXACT"}},"description":"in DYSFIBRIN; fibrinogen Naples and Milano-2; defective thrombin binding resulting in decreased release of fibrinopeptide B; dbSNP:rs121909620","featureCrossReferences":[{"database":"dbSNP","id":"rs121909620"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1634610"}],"featureId":"VAR_002406","alternativeSequence":{"originalSequence":"A","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":100,"modifier":"EXACT"},"end":{"value":100,"modifier":"EXACT"}},"description":"in dbSNP:rs2227434","featureCrossReferences":[{"database":"dbSNP","id":"rs2227434"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.4"}],"featureId":"VAR_013091","alternativeSequence":{"originalSequence":"P","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":170,"modifier":"EXACT"},"end":{"value":170,"modifier":"EXACT"}},"description":"in dbSNP:rs2227409","featureCrossReferences":[{"database":"dbSNP","id":"rs2227409"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.4"}],"featureId":"VAR_013092","alternativeSequence":{"originalSequence":"N","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":196,"modifier":"EXACT"},"end":{"value":196,"modifier":"EXACT"}},"description":"in CAFBN; fibrinogen Longmont; dbSNP:rs121909623","featureCrossReferences":[{"database":"dbSNP","id":"rs121909623"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11468164"}],"featureId":"VAR_016908","alternativeSequence":{"originalSequence":"R","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":202,"modifier":"EXACT"},"end":{"value":202,"modifier":"EXACT"}},"description":"in CAFBN; dbSNP:rs121909624","featureCrossReferences":[{"database":"dbSNP","id":"rs121909624"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15070683"}],"featureId":"VAR_072620","alternativeSequence":{"originalSequence":"L","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":265,"modifier":"EXACT"},"end":{"value":265,"modifier":"EXACT"}},"description":"in dbSNP:rs6054","featureCrossReferences":[{"database":"dbSNP","id":"rs6054"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10391209"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.4"}],"featureId":"VAR_013093","alternativeSequence":{"originalSequence":"P","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":365,"modifier":"EXACT"},"end":{"value":365,"modifier":"EXACT"}},"description":"in Pontoise-2; dbSNP:rs121909617","featureCrossReferences":[{"database":"dbSNP","id":"rs121909617"}],"featureId":"VAR_002407","alternativeSequence":{"originalSequence":"A","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":383,"modifier":"EXACT"},"end":{"value":383,"modifier":"EXACT"}},"description":"in CAFBN; abolishes fibrinogen secretion; dbSNP:rs121909621","featureCrossReferences":[{"database":"dbSNP","id":"rs121909621"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10666208"}],"featureId":"VAR_016909","alternativeSequence":{"originalSequence":"L","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":407,"modifier":"EXACT"},"end":{"value":407,"modifier":"EXACT"}},"description":"in CAFBN; homozygous; heterozygous; no effect on fibrinogen complex assembly; impaired fibrinogen complex secretion","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25427968"}],"featureId":"VAR_072725","alternativeSequence":{"originalSequence":"T","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":430,"modifier":"EXACT"},"end":{"value":430,"modifier":"EXACT"}},"description":"in CAFBN; abolishes fibrinogen secretion; dbSNP:rs121909622","featureCrossReferences":[{"database":"dbSNP","id":"rs121909622"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10666208"}],"featureId":"VAR_016910","alternativeSequence":{"originalSequence":"G","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":478,"modifier":"EXACT"},"end":{"value":478,"modifier":"EXACT"}},"description":"in Baltimore-2; dbSNP:rs4220","featureCrossReferences":[{"database":"dbSNP","id":"rs4220"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10391209"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"3194892"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.4"}],"featureId":"VAR_002408","alternativeSequence":{"originalSequence":"R","alternativeSequences":["K"]}},{"type":"Sequence conflict","location":{"start":{"value":138,"modifier":"EXACT"},"end":{"value":139,"modifier":"EXACT"}},"description":"in Ref. 11; AA sequence and 12; AA sequence","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"SQ","alternativeSequences":["QS"]}},{"type":"Sequence conflict","location":{"start":{"value":145,"modifier":"EXACT"},"end":{"value":146,"modifier":"EXACT"}},"description":"in Ref. 10; AA sequence, 11; AA sequence and 12; AA sequence","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"FQ","alternativeSequences":["QF"]}},{"type":"Sequence conflict","location":{"start":{"value":192,"modifier":"EXACT"},"end":{"value":192,"modifier":"EXACT"}},"description":"in Ref. 1; AAA52429","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"P","alternativeSequences":["A"]}},{"type":"Sequence conflict","location":{"start":{"value":245,"modifier":"EXACT"},"end":{"value":245,"modifier":"EXACT"}},"description":"in Ref. 7; AAI07767","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"I","alternativeSequences":["T"]}},{"type":"Helix","location":{"start":{"value":73,"modifier":"EXACT"},"end":{"value":76,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6BIJ"}]},{"type":"Helix","location":{"start":{"value":78,"modifier":"EXACT"},"end":{"value":80,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6BIJ"}]},{"type":"Turn","location":{"start":{"value":100,"modifier":"EXACT"},"end":{"value":102,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3GHG"}]},{"type":"Helix","location":{"start":{"value":109,"modifier":"EXACT"},"end":{"value":145,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3GHG"}]},{"type":"Helix","location":{"start":{"value":147,"modifier":"EXACT"},"end":{"value":164,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3GHG"}]},{"type":"Helix","location":{"start":{"value":165,"modifier":"EXACT"},"end":{"value":169,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3GHG"}]},{"type":"Helix","location":{"start":{"value":172,"modifier":"EXACT"},"end":{"value":180,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3GHG"}]},{"type":"Turn","location":{"start":{"value":182,"modifier":"EXACT"},"end":{"value":189,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1FZC"}]},{"type":"Helix","location":{"start":{"value":190,"modifier":"EXACT"},"end":{"value":222,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1FZC"}]},{"type":"Beta strand","location":{"start":{"value":224,"modifier":"EXACT"},"end":{"value":226,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2HOD"}]},{"type":"Beta strand","location":{"start":{"value":233,"modifier":"EXACT"},"end":{"value":235,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1FZC"}]},{"type":"Beta strand","location":{"start":{"value":238,"modifier":"EXACT"},"end":{"value":240,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1FZC"}]},{"type":"Helix","location":{"start":{"value":241,"modifier":"EXACT"},"end":{"value":246,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1FZC"}]},{"type":"Beta strand","location":{"start":{"value":253,"modifier":"EXACT"},"end":{"value":257,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1FZC"}]},{"type":"Beta strand","location":{"start":{"value":261,"modifier":"EXACT"},"end":{"value":263,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OYH"}]},{"type":"Beta strand","location":{"start":{"value":266,"modifier":"EXACT"},"end":{"value":271,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1FZC"}]},{"type":"Helix","location":{"start":{"value":274,"modifier":"EXACT"},"end":{"value":276,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1FZC"}]},{"type":"Beta strand","location":{"start":{"value":279,"modifier":"EXACT"},"end":{"value":288,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1FZC"}]},{"type":"Helix","location":{"start":{"value":296,"modifier":"EXACT"},"end":{"value":301,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1FZC"}]},{"type":"Beta strand","location":{"start":{"value":302,"modifier":"EXACT"},"end":{"value":304,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1FZF"}]},{"type":"Beta strand","location":{"start":{"value":306,"modifier":"EXACT"},"end":{"value":308,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1FZC"}]},{"type":"Beta strand","location":{"start":{"value":311,"modifier":"EXACT"},"end":{"value":315,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2H43"}]},{"type":"Beta strand","location":{"start":{"value":321,"modifier":"EXACT"},"end":{"value":323,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1FZC"}]},{"type":"Helix","location":{"start":{"value":326,"modifier":"EXACT"},"end":{"value":334,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1FZC"}]},{"type":"Beta strand","location":{"start":{"value":335,"modifier":"EXACT"},"end":{"value":337,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2HOD"}]},{"type":"Beta strand","location":{"start":{"value":339,"modifier":"EXACT"},"end":{"value":345,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1FZC"}]},{"type":"Beta strand","location":{"start":{"value":347,"modifier":"EXACT"},"end":{"value":349,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1FZA"}]},{"type":"Beta strand","location":{"start":{"value":351,"modifier":"EXACT"},"end":{"value":361,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1FZC"}]},{"type":"Helix","location":{"start":{"value":364,"modifier":"EXACT"},"end":{"value":366,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1FZC"}]},{"type":"Beta strand","location":{"start":{"value":370,"modifier":"EXACT"},"end":{"value":379,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1FZC"}]},{"type":"Helix","location":{"start":{"value":382,"modifier":"EXACT"},"end":{"value":385,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1FZC"}]},{"type":"Beta strand","location":{"start":{"value":388,"modifier":"EXACT"},"end":{"value":390,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2HPC"}]},{"type":"Helix","location":{"start":{"value":392,"modifier":"EXACT"},"end":{"value":396,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1FZC"}]},{"type":"Helix","location":{"start":{"value":403,"modifier":"EXACT"},"end":{"value":405,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1FZC"}]},{"type":"Beta strand","location":{"start":{"value":408,"modifier":"EXACT"},"end":{"value":410,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1FZB"}]},{"type":"Helix","location":{"start":{"value":420,"modifier":"EXACT"},"end":{"value":422,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OYI"}]},{"type":"Turn","location":{"start":{"value":424,"modifier":"EXACT"},"end":{"value":428,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1FZC"}]},{"type":"Helix","location":{"start":{"value":429,"modifier":"EXACT"},"end":{"value":431,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3E1I"}]},{"type":"Beta strand","location":{"start":{"value":435,"modifier":"EXACT"},"end":{"value":437,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1FZC"}]},{"type":"Beta strand","location":{"start":{"value":439,"modifier":"EXACT"},"end":{"value":441,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3E1I"}]},{"type":"Beta strand","location":{"start":{"value":448,"modifier":"EXACT"},"end":{"value":451,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3BVH"}]},{"type":"Turn","location":{"start":{"value":454,"modifier":"EXACT"},"end":{"value":456,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1FZC"}]},{"type":"Beta strand","location":{"start":{"value":457,"modifier":"EXACT"},"end":{"value":461,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3HUS"}]},{"type":"Beta strand","location":{"start":{"value":464,"modifier":"EXACT"},"end":{"value":467,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3E1I"}]},{"type":"Helix","location":{"start":{"value":468,"modifier":"EXACT"},"end":{"value":471,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1FZC"}]},{"type":"Beta strand","location":{"start":{"value":473,"modifier":"EXACT"},"end":{"value":475,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2OYH"}]},{"type":"Beta strand","location":{"start":{"value":478,"modifier":"EXACT"},"end":{"value":485,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1FZC"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-1064","category":"Biological process","name":"Adaptive immunity"},{"id":"KW-0094","category":"Biological process","name":"Blood coagulation"},{"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"id":"KW-0903","category":"Technical term","name":"Direct protein sequencing"},{"id":"KW-0225","category":"Disease","name":"Disease variant"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-0356","category":"Biological process","name":"Hemostasis"},{"id":"KW-0391","category":"Biological process","name":"Immunity"},{"id":"KW-0399","category":"Biological process","name":"Innate immunity"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-0873","category":"PTM","name":"Pyrrolidone carboxylic acid"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"6688356","citationType":"journal article","authors":["Chung D.W.","Que B.G.","Rixon M.W.","Mace M. Jr.","Davie E.W."],"citationCrossReferences":[{"database":"PubMed","id":"6688356"},{"database":"DOI","id":"10.1021/bi00282a032"}],"title":"Characterization of complementary deoxyribonucleic acid and genomic deoxyribonucleic acid for the beta chain of human fibrinogen.","publicationDate":"1983","journal":"Biochemistry","firstPage":"3244","lastPage":"3250","volume":"22"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]"]},{"referenceNumber":2,"citation":{"id":"2102623","citationType":"journal article","authors":["Chung D.W.","Harris J.E.","Davie E.W."],"citationCrossReferences":[{"database":"PubMed","id":"2102623"},{"database":"DOI","id":"10.1007/978-1-4615-3806-6_3"}],"title":"Nucleotide sequences of the three genes coding for human fibrinogen.","publicationDate":"1990","journal":"Adv. Exp. Med. Biol.","firstPage":"39","lastPage":"48","volume":"281"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":3,"citation":{"id":"CI-210NJSGHLG3O4","citationType":"book","authors":["Chung D.W.","Harris J.E.","Davie E.W."],"title":"Nucleotide sequences of the three genes coding for human fibrinogen.","publicationDate":"1991","bookName":"Fibrinogen, thrombosis, coagulation and fibrinolysis","editors":["Liu C.Y.","Chien S."],"firstPage":"39","lastPage":"48","publisher":"Plenum Press","address":"New York"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":4,"citation":{"id":"CI-6O517G2GQVJPC","citationType":"submission","authoringGroup":["SeattleSNPs variation discovery resource"],"publicationDate":"JUN-2001","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]","VARIANTS SER-100; HIS-170; LEU-265 AND LYS-478"]},{"referenceNumber":5,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Mammary gland","type":"TISSUE"}]},{"referenceNumber":6,"citation":{"id":"CI-5GBD0VIIJ7C63","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"SEP-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":7,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":8,"citation":{"id":"6575700","citationType":"journal article","authors":["Chung D.W.","Rixon M.W.","Que B.G.","Davie E.W."],"citationCrossReferences":[{"database":"PubMed","id":"6575700"},{"database":"DOI","id":"10.1111/j.1749-6632.1983.tb23265.x"}],"title":"Cloning of fibrinogen genes and their cDNA.","publicationDate":"1983","journal":"Ann. N. Y. Acad. Sci.","firstPage":"449","lastPage":"456","volume":"408"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF 1-60"]},{"referenceNumber":9,"citation":{"id":"3029722","citationType":"journal article","authors":["Huber P.","Dalmon J.","Courtois G.","Laurent M.","Assouline Z.","Marguerie G."],"citationCrossReferences":[{"database":"PubMed","id":"3029722"},{"database":"DOI","id":"10.1093/nar/15.4.1615"}],"title":"Characterization of the 5'-flanking region for the human fibrinogen beta gene.","publicationDate":"1987","journal":"Nucleic Acids Res.","firstPage":"1615","lastPage":"1625","volume":"15"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-38"]},{"referenceNumber":10,"citation":{"id":"420779","citationType":"journal article","authors":["Watt K.W.K.","Takagi T.","Doolittle R.F."],"citationCrossReferences":[{"database":"PubMed","id":"420779"},{"database":"DOI","id":"10.1021/bi00568a011"}],"title":"Amino acid sequence of the beta chain of human fibrinogen.","publicationDate":"1979","journal":"Biochemistry","firstPage":"68","lastPage":"76","volume":"18"},"referencePositions":["PROTEIN SEQUENCE OF 31-491","PYROGLUTAMATE FORMATION AT GLN-31"]},{"referenceNumber":11,"citation":{"id":"CI-2V820EV9G7CI9","citationType":"book","authors":["Henschen A.","Lottspeich F.","Southan C.","Topfer-Petersen E."],"title":"Human fibrinogen: sequence, sulfur bridges, glycosylation and some structural variants.","publicationDate":"1980","bookName":"Protides of the biological fluids, Proc. 28th colloquium","editors":["Peeters H."],"firstPage":"51","lastPage":"56","publisher":"Pergamon Press","address":"Oxford"},"referencePositions":["PROTEIN SEQUENCE OF 31-491","GLYCOSYLATION AT ASN-394"]},{"referenceNumber":12,"citation":{"id":"936108","citationType":"journal article","authors":["Blombaeck B.","Hessel B.","Hogg D."],"citationCrossReferences":[{"database":"PubMed","id":"936108"},{"database":"DOI","id":"10.1016/0049-3848(76)90245-0"}],"title":"Disulfide bridges in NH2-terminal part of human fibrinogen.","publicationDate":"1976","journal":"Thromb. Res.","firstPage":"639","lastPage":"658","volume":"8"},"referencePositions":["PROTEIN SEQUENCE OF 31-148","DISULFIDE BONDS"]},{"referenceNumber":13,"citation":{"id":"CI-8R58GEEP6P435","citationType":"journal article","authors":["Blombaeck B.","Blombaeck M.","Grondahl N.J.","Guthrie C.","Hinton M."],"title":"Studies on fibrinopeptides from primates.","publicationDate":"1965","journal":"Acta Chem. Scand.","firstPage":"1788","lastPage":"1789","volume":"19"},"referencePositions":["PROTEIN SEQUENCE OF 31-44"]},{"referenceNumber":14,"citation":{"id":"12665801","citationType":"journal article","authors":["Gevaert K.","Goethals M.","Martens L.","Van Damme J.","Staes A.","Thomas G.R.","Vandekerckhove J."],"citationCrossReferences":[{"database":"PubMed","id":"12665801"},{"database":"DOI","id":"10.1038/nbt810"}],"title":"Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.","publicationDate":"2003","journal":"Nat. Biotechnol.","firstPage":"566","lastPage":"569","volume":"21"},"referencePositions":["PROTEIN SEQUENCE OF 45-53"],"referenceComments":[{"value":"Platelet","type":"TISSUE"}]},{"referenceNumber":15,"citation":{"id":"CI-652NQH91LIDA8","citationType":"submission","authors":["Lubec G.","Chen W.-Q.","Sun Y."],"publicationDate":"DEC-2008","submissionDatabase":"UniProtKB"},"referencePositions":["PROTEIN SEQUENCE OF 54-72; 164-178 AND 225-239","IDENTIFICATION BY MASS SPECTROMETRY"],"referenceComments":[{"value":"Fetal brain cortex","type":"TISSUE"}]},{"referenceNumber":16,"citation":{"id":"6575689","citationType":"journal article","authors":["Henschen A.","Lottspeich F.","Kehl M.","Southan C."],"citationCrossReferences":[{"database":"PubMed","id":"6575689"},{"database":"DOI","id":"10.1111/j.1749-6632.1983.tb23232.x"}],"title":"Covalent structure of fibrinogen.","publicationDate":"1983","journal":"Ann. N. Y. Acad. Sci.","firstPage":"28","lastPage":"43","volume":"408"},"referencePositions":["REVIEW","DISULFIDE BONDS"]},{"referenceNumber":17,"citation":{"id":"891553","citationType":"journal article","authors":["Gaardlund B.","Hessel B.","Marguerie G.","Murano G.","Blombaeck B."],"citationCrossReferences":[{"database":"PubMed","id":"891553"},{"database":"DOI","id":"10.1111/j.1432-1033.1977.tb11704.x"}],"title":"Primary structure of human fibrinogen. Characterization of disulfide-containing cyanogen-bromide fragments.","publicationDate":"1977","journal":"Eur. J. Biochem.","firstPage":"595","lastPage":"610","volume":"77"},"referencePositions":["DISULFIDE BONDS"]},{"referenceNumber":18,"citation":{"id":"CI-CEV8E1H0RCTHT","citationType":"book","authors":["Doolittle R.F.","Takagi T.","Watt K.W.K.","Bouma H. III","Cottrell B.A.","Cassman K.G.","Goldbaum D.M.","Doolittle L.R.","Friezner S.J."],"title":"The structures of fibrinogen and fibrin.","publicationDate":"1978","bookName":"Regulatory proteolytic enzymes and their inhibitors","editors":["Magnusson S.","Ottesen M.","Foltmann B.","Dano K.","Neurath H."],"firstPage":"163","lastPage":"172","publisher":"Pergamon Press","address":"New York"},"referencePositions":["DISULFIDE BONDS"]},{"referenceNumber":19,"citation":{"id":"6383194","citationType":"journal article","authors":["Doolittle R.F."],"citationCrossReferences":[{"database":"PubMed","id":"6383194"},{"database":"DOI","id":"10.1146/annurev.bi.53.070184.001211"}],"title":"Fibrinogen and fibrin.","publicationDate":"1984","journal":"Annu. Rev. Biochem.","firstPage":"195","lastPage":"229","volume":"53"},"referencePositions":["REVIEW","ELECTRON MICROSCOPY","POLYMERIZATION","LIGANDS"]},{"referenceNumber":20,"citation":{"id":"7642629","citationType":"journal article","authors":["Tran H.","Tanaka A.","Litvinovich S.V.","Medved L.V.","Haudenschild C.C.","Argraves W.S."],"citationCrossReferences":[{"database":"PubMed","id":"7642629"},{"database":"DOI","id":"10.1074/jbc.270.33.19458"}],"title":"The interaction of fibulin-1 with fibrinogen. A potential role in hemostasis and thrombosis.","publicationDate":"1995","journal":"J. Biol. Chem.","firstPage":"19458","lastPage":"19464","volume":"270"},"referencePositions":["INTERACTION WITH FBLN1"]},{"referenceNumber":21,"citation":{"id":"16335952","citationType":"journal article","authors":["Liu T.","Qian W.-J.","Gritsenko M.A.","Camp D.G. II","Monroe M.E.","Moore R.J.","Smith R.D."],"citationCrossReferences":[{"database":"PubMed","id":"16335952"},{"database":"DOI","id":"10.1021/pr0502065"}],"title":"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.","publicationDate":"2005","journal":"J. Proteome Res.","firstPage":"2070","lastPage":"2080","volume":"4"},"referencePositions":["GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-394"],"referenceComments":[{"value":"Plasma","type":"TISSUE"}]},{"referenceNumber":22,"citation":{"id":"16263699","citationType":"journal article","authors":["Lewandrowski U.","Moebius J.","Walter U.","Sickmann A."],"citationCrossReferences":[{"database":"PubMed","id":"16263699"},{"database":"DOI","id":"10.1074/mcp.m500324-mcp200"}],"title":"Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach.","publicationDate":"2006","journal":"Mol. Cell. Proteomics","firstPage":"226","lastPage":"233","volume":"5"},"referencePositions":["GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-394"],"referenceComments":[{"value":"Platelet","type":"TISSUE"}]},{"referenceNumber":23,"citation":{"id":"19159218","citationType":"journal article","authors":["Chen R.","Jiang X.","Sun D.","Han G.","Wang F.","Ye M.","Wang L.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"19159218"},{"database":"DOI","id":"10.1021/pr8008012"}],"title":"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.","publicationDate":"2009","journal":"J. Proteome Res.","firstPage":"651","lastPage":"661","volume":"8"},"referencePositions":["GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-394"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":24,"citation":{"id":"2143188","citationType":"journal article","authors":["Kirschbaum N.E.","Budzynski A.Z."],"citationCrossReferences":[{"database":"PubMed","id":"2143188"},{"database":"DOI","id":"10.1016/s0021-9258(18)77401-2"}],"title":"A unique proteolytic fragment of human fibrinogen containing the A alpha COOH-terminal domain of the native molecule.","publicationDate":"1990","journal":"J. Biol. Chem.","firstPage":"13669","lastPage":"13676","volume":"265"},"referencePositions":["CLEAVAGE BY HEMENTIN AND PLASMIN"]},{"referenceNumber":25,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Buerckstuemmer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":26,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":27,"citation":{"id":"9333233","citationType":"journal article","authors":["Spraggon G.","Everse S.J.","Doolittle R.F."],"citationCrossReferences":[{"database":"PubMed","id":"9333233"},{"database":"DOI","id":"10.1038/38947"}],"title":"Crystal structures of fragment D from human fibrinogen and its crosslinked counterpart from fibrin.","publicationDate":"1997","journal":"Nature","firstPage":"455","lastPage":"462","volume":"389"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.90 ANGSTROMS) OF 164-491","DISULFIDE BONDS","SUBUNIT"]},{"referenceNumber":28,"citation":{"id":"9628725","citationType":"journal article","authors":["Everse S.J.","Spraggon G.","Veerapandian L.","Riley M.","Doolittle R.F."],"citationCrossReferences":[{"database":"PubMed","id":"9628725"},{"database":"DOI","id":"10.1021/bi9804129"}],"title":"Crystal structure of fragment double-D from human fibrin with two different bound ligands.","publicationDate":"1998","journal":"Biochemistry","firstPage":"8637","lastPage":"8642","volume":"37"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 164-491 IN COMPLEX WITH CALCIUM","DISULFIDE BONDS","GLYCOSYLATION AT ASN-394","SUBUNIT","COILED COIL DOMAIN","SUBCELLULAR LOCATION","TISSUE SPECIFICITY"]},{"referenceNumber":29,"citation":{"id":"10074346","citationType":"journal article","authors":["Everse S.J.","Spraggon G.","Veerapandian L.","Doolittle R.F."],"citationCrossReferences":[{"database":"PubMed","id":"10074346"},{"database":"DOI","id":"10.1021/bi982626w"}],"title":"Conformational changes in fragments D and double-D from human fibrin(ogen) upon binding the peptide ligand Gly-His-Arg-Pro-amide.","publicationDate":"1999","journal":"Biochemistry","firstPage":"2941","lastPage":"2946","volume":"38"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 164-491 IN COMPLEX WITH CALCIUM","DISULFIDE BONDS","GLYCOSYLATION AT ASN-394","SUBUNIT","SUBCELLULAR LOCATION","TISSUE SPECIFICITY","COILED COIL DOMAIN"]},{"referenceNumber":30,"citation":{"id":"19296670","citationType":"journal article","authors":["Kollman J.M.","Pandi L.","Sawaya M.R.","Riley M.","Doolittle R.F."],"citationCrossReferences":[{"database":"PubMed","id":"19296670"},{"database":"DOI","id":"10.1021/bi802205g"}],"title":"Crystal structure of human fibrinogen.","publicationDate":"2009","journal":"Biochemistry","firstPage":"3877","lastPage":"3886","volume":"48"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.90 ANGSTROMS) OF 31-491 IN COMPLEX WITH CALCIUM","DISULFIDE BONDS","GLYCOSYLATION AT ASN-394","SUBUNIT","SUBCELLULAR LOCATION","TISSUE SPECIFICITY","COILED COIL DOMAIN"]},{"referenceNumber":31,"citation":{"id":"3194892","citationType":"journal article","authors":["Schmelzer C.H.","Ebert R.F.","Bell W.R."],"citationCrossReferences":[{"database":"PubMed","id":"3194892"},{"database":"DOI","id":"10.1016/0049-3848(88)90096-5"}],"title":"A polymorphism at B beta 448 of fibrinogen identified during structural studies of fibrinogen Baltimore II.","publicationDate":"1988","journal":"Thromb. Res.","firstPage":"173","lastPage":"177","volume":"52"},"referencePositions":["VARIANT LYS-478"]},{"referenceNumber":32,"citation":{"id":"2018836","citationType":"journal article","authors":["Yoshida N.","Wada H.","Morita K.","Hirata H.","Matsuda M.","Yamazumi K.","Asakura S.","Shirakawa S."],"citationCrossReferences":[{"database":"PubMed","id":"2018836"},{"database":"DOI","id":"10.1182/blood.v77.9.1958.1958"}],"title":"A new congenital abnormal fibrinogen Ise characterized by the replacement of B beta glycine-15 by cysteine.","publicationDate":"1991","journal":"Blood","firstPage":"1958","lastPage":"1963","volume":"77"},"referencePositions":["VARIANT ARG-45"]},{"referenceNumber":33,"citation":{"id":"1634610","citationType":"journal article","authors":["Koopman J.","Haverkate F.","Lord S.T.","Grimbergen J.","Mannucci P.M."],"citationCrossReferences":[{"database":"PubMed","id":"1634610"},{"database":"DOI","id":"10.1172/jci115841"}],"title":"Molecular basis of fibrinogen Naples associated with defective thrombin binding and thrombophilia. Homozygous substitution of B beta 68 Ala-->Thr.","publicationDate":"1992","journal":"J. Clin. Invest.","firstPage":"238","lastPage":"244","volume":"90"},"referencePositions":["INVOLVEMENT IN DYSFIBRIN","VARIANT DYSFIBRIN THR-98"]},{"referenceNumber":34,"citation":{"id":"1565641","citationType":"journal article","authors":["Koopman J.","Haverkate F.","Grimbergen J.","Engesser L.","Novakova I.","Kerst A.F.J.A.","Lord S.T."],"citationCrossReferences":[{"database":"PubMed","id":"1565641"},{"database":"DOI","id":"10.1073/pnas.89.8.3478"}],"title":"Abnormal fibrinogens IJmuiden (B beta Arg14-->Cys) and Nijmegen (B beta Arg44-->Cys) form disulfide-linked fibrinogen-albumin complexes.","publicationDate":"1992","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"3478","lastPage":"3482","volume":"89"},"referencePositions":["VARIANTS CYS-44 AND CYS-74"]},{"referenceNumber":35,"citation":{"id":"3156856","citationType":"journal article","authors":["Liu C.Y.","Koehn J.A.","Morgan F.J."],"citationCrossReferences":[{"database":"PubMed","id":"3156856"},{"database":"DOI","id":"10.1016/s0021-9258(18)89277-8"}],"title":"Characterization of fibrinogen New York 1. A dysfunctional fibrinogen with a deletion of B beta(9-72) corresponding exactly to exon 2 of the gene.","publicationDate":"1985","journal":"J. Biol. Chem.","firstPage":"4390","lastPage":"4396","volume":"260"},"referencePositions":["VARIANT 39-GLY--LEU-102 DEL"]},{"referenceNumber":36,"citation":{"id":"10391209","citationType":"journal article","authors":["Cargill M.","Altshuler D.","Ireland J.","Sklar P.","Ardlie K.","Patil N.","Shaw N.","Lane C.R.","Lim E.P.","Kalyanaraman N.","Nemesh J.","Ziaugra L.","Friedland L.","Rolfe A.","Warrington J.","Lipshutz R.","Daley G.Q.","Lander E.S."],"citationCrossReferences":[{"database":"PubMed","id":"10391209"},{"database":"DOI","id":"10.1038/10290"}],"title":"Characterization of single-nucleotide polymorphisms in coding regions of human genes.","publicationDate":"1999","journal":"Nat. Genet.","firstPage":"231","lastPage":"238","volume":"22"},"referencePositions":["VARIANTS GLU-2; LEU-265 AND LYS-478"]},{"referenceNumber":37,"citation":{"id":"CI-7BM7J78BCMMM4","citationType":"journal article","authors":["Cargill M.","Altshuler D.","Ireland J.","Sklar P.","Ardlie K.","Patil N.","Shaw N.","Lane C.R.","Lim E.P.","Kalyanaraman N.","Nemesh J.","Ziaugra L.","Friedland L.","Rolfe A.","Warrington J.","Lipshutz R.","Daley G.Q.","Lander E.S."],"publicationDate":"1999","journal":"Nat. Genet.","firstPage":"373","lastPage":"373","volume":"23"},"referencePositions":["ERRATUM OF PUBMED:10391209"]},{"referenceNumber":38,"citation":{"id":"10666208","citationType":"journal article","authors":["Duga S.","Asselta R.","Santagostino E.","Zeinali S.","Simonic T.","Malcovati M.","Mannucci P.M.","Tenchini M.L."],"citationCrossReferences":[{"database":"PubMed","id":"10666208"},{"database":"DOI","id":"10.1182/blood.v95.4.1336.004k16_1336_1341"}],"title":"Missense mutations in the human beta fibrinogen gene cause congenital afibrinogenemia by impairing fibrinogen secretion.","publicationDate":"2000","journal":"Blood","firstPage":"1336","lastPage":"1341","volume":"95"},"referencePositions":["VARIANTS CAFBN ARG-383 AND ASP-430"]},{"referenceNumber":39,"citation":{"id":"11468164","citationType":"journal article","authors":["Lounes K.C.","Lefkowitz J.B.","Henschen-Edman A.H.","Coates A.I.","Hantgan R.R.","Lord S.T."],"citationCrossReferences":[{"database":"PubMed","id":"11468164"},{"database":"DOI","id":"10.1182/blood.v98.3.661"}],"title":"The impaired polymerization of fibrinogen Longmont (Bbeta166Arg-->Cys) is not improved by removal of disulfide-linked dimers from a mixture of dimers and cysteine-linked monomers.","publicationDate":"2001","journal":"Blood","firstPage":"661","lastPage":"666","volume":"98"},"referencePositions":["VARIANT CAFBN CYS-196"]},{"referenceNumber":40,"citation":{"id":"15070683","citationType":"journal article","authors":["Asselta R.","Duga S.","Spena S.","Peyvandi F.","Castaman G.","Malcovati M.","Mannucci P.M.","Tenchini M.L."],"citationCrossReferences":[{"database":"PubMed","id":"15070683"},{"database":"DOI","id":"10.1182/blood-2003-10-3725"}],"title":"Missense or splicing mutation? The case of a fibrinogen Bbeta-chain mutation causing severe hypofibrinogenemia.","publicationDate":"2004","journal":"Blood","firstPage":"3051","lastPage":"3054","volume":"103"},"referencePositions":["VARIANT CAFBN GLN-202"]},{"referenceNumber":41,"citation":{"id":"25427968","citationType":"journal article","authors":["Asselta R.","Plate M.","Robusto M.","Borhany M.","Guella I.","Solda G.","Afrasiabi A.","Menegatti M.","Shamsi T.","Peyvandi F.","Duga S."],"citationCrossReferences":[{"database":"PubMed","id":"25427968"},{"database":"DOI","id":"10.1160/th14-07-0629"}],"title":"Clinical and molecular characterisation of 21 patients affected by quantitative fibrinogen deficiency.","publicationDate":"2015","journal":"Thromb. Haemost.","firstPage":"567","lastPage":"576","volume":"113"},"referencePositions":["VARIANTS CAFBN ARG-95 AND LYS-407","CHARACTERIZATION OF VARIANTS CAFBN ARG-95 AND LYS-407"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"J00129","properties":[{"key":"ProteinId","value":"AAA52429.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"J00131","properties":[{"key":"ProteinId","value":"AAA98115.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"J00130","properties":[{"key":"ProteinId","value":"AAA98115.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"J00132","properties":[{"key":"ProteinId","value":"AAA98116.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"J00133","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"M64983","properties":[{"key":"ProteinId","value":"AAA18024.2"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF388026","properties":[{"key":"ProteinId","value":"AAK62470.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AK312972","properties":[{"key":"ProteinId","value":"BAG35810.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"CH471056","properties":[{"key":"ProteinId","value":"EAX04932.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC007030","properties":[{"key":"ProteinId","value":"AAH07030.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC106760","properties":[{"key":"ProteinId","value":"AAI06761.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC107766","properties":[{"key":"ProteinId","value":"AAI07767.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AH002694","properties":[{"key":"ProteinId","value":"AAA52445.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"X05018","properties":[{"key":"ProteinId","value":"CAA28674.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"CCDS","id":"CCDS3786.1","properties":[{"key":"Description","value":"-"}]},{"database":"PIR","id":"B43568","properties":[{"key":"EntryName","value":"FGHUB"}]},{"database":"RefSeq","id":"NP_001171670.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001184741.1"}]},{"database":"RefSeq","id":"NP_005132.2","properties":[{"key":"NucleotideSequenceId","value":"NM_005141.5"}]},{"database":"PDB","id":"1FZA","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.90 A"},{"key":"Chains","value":"B/E=164-491"}]},{"database":"PDB","id":"1FZB","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.90 A"},{"key":"Chains","value":"B/E=164-491"}]},{"database":"PDB","id":"1FZC","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"B/E=164-491"}]},{"database":"PDB","id":"1FZE","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.00 A"},{"key":"Chains","value":"B/E=164-491"}]},{"database":"PDB","id":"1FZF","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.70 A"},{"key":"Chains","value":"B/E=164-491, M/N/S/T=45-48"}]},{"database":"PDB","id":"1FZG","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"B/E=164-491"}]},{"database":"PDB","id":"1LT9","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.80 A"},{"key":"Chains","value":"B/E=179-491"}]},{"database":"PDB","id":"1LTJ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.80 A"},{"key":"Chains","value":"B/E=179-491"}]},{"database":"PDB","id":"1N73","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.90 A"},{"key":"Chains","value":"G/H/I/J=45-48"}]},{"database":"PDB","id":"1N86","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.20 A"},{"key":"Chains","value":"B/E=164-491, I/J=45-51"}]},{"database":"PDB","id":"1N8E","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"4.50 A"},{"key":"Chains","value":"B/E=164-491"}]},{"database":"PDB","id":"1RE3","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.45 A"},{"key":"Chains","value":"B/E=179-491"}]},{"database":"PDB","id":"1RE4","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.70 A"},{"key":"Chains","value":"B/E=179-491"}]},{"database":"PDB","id":"1RF0","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.81 A"},{"key":"Chains","value":"B/E=179-491"}]},{"database":"PDB","id":"1RF1","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.53 A"},{"key":"Chains","value":"B/E=179-491"}]},{"database":"PDB","id":"2A45","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.65 A"},{"key":"Chains","value":"H/K=45-135"}]},{"database":"PDB","id":"2FFD","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.89 A"},{"key":"Chains","value":"B/E=179-491"}]},{"database":"PDB","id":"2H43","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.70 A"},{"key":"Chains","value":"B/E=164-491"}]},{"database":"PDB","id":"2HLO","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.60 A"},{"key":"Chains","value":"B/E=164-491"}]},{"database":"PDB","id":"2HOD","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.90 A"},{"key":"Chains","value":"B/E/H/K=164-491"}]},{"database":"PDB","id":"2HPC","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.90 A"},{"key":"Chains","value":"B/E/H/K=164-491"}]},{"database":"PDB","id":"2OYH","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.40 A"},{"key":"Chains","value":"B/E=179-491"}]},{"database":"PDB","id":"2OYI","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.70 A"},{"key":"Chains","value":"B/E=179-491"}]},{"database":"PDB","id":"2Q9I","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.80 A"},{"key":"Chains","value":"B/E=164-491"}]},{"database":"PDB","id":"2XNX","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.30 A"},{"key":"Chains","value":"B/E/H/K=164-491"}]},{"database":"PDB","id":"2XNY","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"7.50 A"},{"key":"Chains","value":"B/E=164-491"}]},{"database":"PDB","id":"2Z4E","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.70 A"},{"key":"Chains","value":"B/E=164-489"}]},{"database":"PDB","id":"3BVH","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.60 A"},{"key":"Chains","value":"B/E=191-488"}]},{"database":"PDB","id":"3E1I","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"B/E=164-491"}]},{"database":"PDB","id":"3GHG","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.90 A"},{"key":"Chains","value":"B/E/H/K=31-491"}]},{"database":"PDB","id":"3H32","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.60 A"},{"key":"Chains","value":"B/E=31-488"}]},{"database":"PDB","id":"3HUS","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.04 A"},{"key":"Chains","value":"B/E=179-491"}]},{"database":"PDB","id":"6ATZ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.70 A"},{"key":"Chains","value":"E/F=69-79"}]},{"database":"PDB","id":"6BIJ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.10 A"},{"key":"Chains","value":"C=69-81"}]},{"database":"PDB","id":"6BIL","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.40 A"},{"key":"Chains","value":"C=69-81"}]},{"database":"PDB","id":"6V0Y","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.70 A"},{"key":"Chains","value":"C=69-81"}]},{"database":"PDB","id":"6V13","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.75 A"},{"key":"Chains","value":"C=69-81"}]},{"database":"PDB","id":"6V15","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.80 A"},{"key":"Chains","value":"C=69-81"}]},{"database":"PDB","id":"6V18","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.35 A"},{"key":"Chains","value":"C=69-81"}]},{"database":"PDB","id":"6V19","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.60 A"},{"key":"Chains","value":"C=69-81"}]},{"database":"PDB","id":"6V1A","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.29 A"},{"key":"Chains","value":"C=69-81"}]},{"database":"PDBsum","id":"1FZA","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1FZB","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1FZC","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1FZE","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1FZF","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1FZG","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1LT9","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1LTJ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1N73","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1N86","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1N8E","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1RE3","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1RE4","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1RF0","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1RF1","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2A45","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2FFD","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2H43","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2HLO","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2HOD","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2HPC","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2OYH","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2OYI","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2Q9I","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2XNX","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2XNY","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2Z4E","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3BVH","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3E1I","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3GHG","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3H32","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3HUS","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6ATZ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6BIJ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6BIL","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6V0Y","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6V13","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6V15","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6V18","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6V19","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6V1A","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"P02675","properties":[{"key":"Description","value":"-"}]},{"database":"MDposit","id":"P02675","properties":[{"key":"Description","value":"-"}]},{"database":"MDRepo","id":"P02675","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P02675","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"108535","properties":[{"key":"Interactions","value":"244"}]},{"database":"ComplexPortal","id":"CPX-1922","properties":[{"key":"EntryName","value":"Fibrinogen complex"}]},{"database":"ComplexPortal","id":"CPX-6225","properties":[{"key":"EntryName","value":"Fibrin complex"}]},{"database":"CORUM","id":"P02675","properties":[{"key":"Description","value":"-"}]},{"database":"DIP","id":"DIP-385N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P02675","properties":[{"key":"Number of interactors","value":"400"}]},{"database":"IntAct","id":"P02675","properties":[{"key":"Interactions","value":"168"}]},{"database":"MINT","id":"P02675","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-FGB","properties":[{"key":"Evidences","value":"17 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000306099","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"P02675","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL2048","properties":[{"key":"Description","value":"-"}]},{"database":"DrugBank","id":"DB04919","properties":[{"key":"GenericName","value":"Alfimeprase"}]},{"database":"DrugBank","id":"DB13151","properties":[{"key":"GenericName","value":"Anti-inhibitor coagulant complex"}]},{"database":"DrugBank","id":"DB11571","properties":[{"key":"GenericName","value":"Human thrombin"}]},{"database":"DrugBank","id":"DB11311","properties":[{"key":"GenericName","value":"Prothrombin"}]},{"database":"DrugBank","id":"DB00364","properties":[{"key":"GenericName","value":"Sucralfate"}]},{"database":"DrugBank","id":"DB11300","properties":[{"key":"GenericName","value":"Thrombin"}]},{"database":"DrugBank","id":"DB11572","properties":[{"key":"GenericName","value":"Thrombin alfa"}]},{"database":"UniLectin","id":"P02675","properties":[{"key":"Description","value":"-"}]},{"database":"CarbonylDB","id":"P02675","properties":[{"key":"Description","value":"-"}]},{"database":"GlyConnect","id":"P02675","properties":[{"key":"glycosylation","value":"32 N-Linked glycans (1 site)"}]},{"database":"GlyCosmos","id":"P02675","properties":[{"key":"glycosylation","value":"3 sites, 33 glycans"}]},{"database":"GlyGen","id":"P02675","properties":[{"key":"glycosylation","value":"9 sites, 119 N-linked glycans (2 sites), 5 O-linked glycans (6 sites)"}]},{"database":"iPTMnet","id":"P02675","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"P02675","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"P02675","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"FGB","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"399492","properties":[{"key":"Description","value":"-"}]},{"database":"OGP","id":"P02675","properties":[{"key":"Description","value":"-"}]},{"database":"REPRODUCTION-2DPAGE","id":"IPI00298497","properties":[{"key":"Description","value":"-"}]},{"database":"REPRODUCTION-2DPAGE","id":"P02675","properties":[{"key":"Description","value":"-"}]},{"database":"CPTAC","id":"non-CPTAC-1119","properties":[{"key":"Description","value":"-"}]},{"database":"CPTAC","id":"non-CPTAC-1120","properties":[{"key":"Description","value":"-"}]},{"database":"CPTAC","id":"non-CPTAC-2665","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"P02675","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"P02675","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000306099","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P02675","properties":[{"key":"Description","value":"-"}]},{"database":"PRIDE","id":"P02675","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"51544","properties":[{"key":"Description","value":"-"}]},{"database":"Pumba","id":"P02675","properties":[{"key":"Description","value":"-"}]},{"database":"ABCD","id":"P02675","properties":[{"key":"antibodies","value":"8 sequenced antibodies"}]},{"database":"Antibodypedia","id":"855","properties":[{"key":"antibodies","value":"636 antibodies from 40 providers"}]},{"database":"DNASU","id":"2244","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000302068.9","properties":[{"key":"ProteinId","value":"ENSP00000306099.4"},{"key":"GeneId","value":"ENSG00000171564.13"}]},{"database":"GeneID","id":"2244","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:2244","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000302068.9","properties":[{"key":"ProteinId","value":"ENSP00000306099.4"},{"key":"RefSeqNucleotideId","value":"NM_005141.5"},{"key":"RefSeqProteinId","value":"NP_005132.2"}]},{"database":"AGR","id":"HGNC:3662","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA163","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"2244","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"2244","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"FGB","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:3662","properties":[{"key":"GeneName","value":"FGB"}]},{"database":"HPA","id":"ENSG00000171564","properties":[{"key":"ExpressionPatterns","value":"Tissue enriched (liver)"}]},{"database":"MalaCards","id":"FGB","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"134830","properties":[{"key":"Type","value":"gene"}]},{"database":"MIM","id":"202400","properties":[{"key":"Type","value":"phenotype"}]},{"database":"MIM","id":"616004","properties":[{"key":"Type","value":"phenotype"}]},{"database":"OpenTargets","id":"ENSG00000171564","properties":[{"key":"Description","value":"-"}]},{"database":"Orphanet","id":"98880","properties":[{"key":"Disease","value":"Familial afibrinogenemia"}]},{"database":"Orphanet","id":"98881","properties":[{"key":"Disease","value":"Familial dysfibrinogenemia"}]},{"database":"Orphanet","id":"248408","properties":[{"key":"Disease","value":"Familial hypodysfibrinogenemia"}]},{"database":"Orphanet","id":"101041","properties":[{"key":"Disease","value":"Familial hypofibrinogenemia"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000171564","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG2579","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000158122","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_038628_13_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P02675","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"GCIHADP","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9930906at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"P02675","properties":[{"key":"Number of GO annotations","value":"5 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"P02675","properties":[{"key":"Description","value":"-"}]},{"database":"BioCyc","id":"MetaCyc:ENSG00000171564-MONOMER","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"P02675","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-114608","properties":[{"key":"PathwayName","value":"Platelet degranulation"}]},{"database":"Reactome","id":"R-HSA-1236974","properties":[{"key":"PathwayName","value":"ER-Phagosome pathway"}]},{"database":"Reactome","id":"R-HSA-166058","properties":[{"key":"PathwayName","value":"MyD88:MAL(TIRAP) cascade initiated on plasma membrane"}]},{"database":"Reactome","id":"R-HSA-216083","properties":[{"key":"PathwayName","value":"Integrin cell surface interactions"}]},{"database":"Reactome","id":"R-HSA-354192","properties":[{"key":"PathwayName","value":"Integrin signaling"}]},{"database":"Reactome","id":"R-HSA-354194","properties":[{"key":"PathwayName","value":"GRB2:SOS provides linkage to MAPK signaling for Integrins"}]},{"database":"Reactome","id":"R-HSA-372708","properties":[{"key":"PathwayName","value":"p130Cas linkage to MAPK signaling for integrins"}]},{"database":"Reactome","id":"R-HSA-5602498","properties":[{"key":"PathwayName","value":"MyD88 deficiency (TLR2/4)"}]},{"database":"Reactome","id":"R-HSA-5603041","properties":[{"key":"PathwayName","value":"IRAK4 deficiency (TLR2/4)"}]},{"database":"Reactome","id":"R-HSA-5674135","properties":[{"key":"PathwayName","value":"MAP2K and MAPK activation"}]},{"database":"Reactome","id":"R-HSA-5686938","properties":[{"key":"PathwayName","value":"Regulation of TLR by endogenous ligand"}]},{"database":"Reactome","id":"R-HSA-6802946","properties":[{"key":"PathwayName","value":"Signaling by moderate kinase activity BRAF mutants"}]},{"database":"Reactome","id":"R-HSA-6802948","properties":[{"key":"PathwayName","value":"Signaling by high-kinase activity BRAF mutants"}]},{"database":"Reactome","id":"R-HSA-6802952","properties":[{"key":"PathwayName","value":"Signaling by BRAF and RAF1 fusions"}]},{"database":"Reactome","id":"R-HSA-6802955","properties":[{"key":"PathwayName","value":"Paradoxical activation of RAF signaling by kinase inactive BRAF"}]},{"database":"Reactome","id":"R-HSA-9649948","properties":[{"key":"PathwayName","value":"Signaling downstream of RAS mutants"}]},{"database":"Reactome","id":"R-HSA-9656223","properties":[{"key":"PathwayName","value":"Signaling by RAF1 mutants"}]},{"database":"Reactome","id":"R-HSA-9769733","properties":[{"key":"PathwayName","value":"Fibrin formation"}]},{"database":"Reactome","id":"R-HSA-9936686","properties":[{"key":"PathwayName","value":"Aggregated Beta-amyloid interacts with fibrinogen"}]},{"database":"SignaLink","id":"P02675","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"P02675","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000171564","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"2244","properties":[{"key":"hits","value":"15 hits in 1148 CRISPR screens"}]},{"database":"CD-CODE","id":"FB4E32DD","properties":[{"key":"EntryName","value":"Presynaptic clusters and postsynaptic densities"}]},{"database":"ChiTaRS","id":"FGB","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"P02675","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"Fibrinogen_beta_chain","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"2244","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"P02675","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:P02675","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 4"}]},{"database":"RNAct","id":"P02675","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000171564","properties":[{"key":"ExpressionPatterns","value":"Expressed in right lobe of liver and 119 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"P02675","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0072562","properties":[{"key":"GoTerm","value":"C:blood microparticle"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"22516433"}]},{"database":"GO","id":"GO:0005938","properties":[{"key":"GoTerm","value":"C:cell cortex"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0009986","properties":[{"key":"GoTerm","value":"C:cell surface"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"6777381"}]},{"database":"GO","id":"GO:0005783","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0009897","properties":[{"key":"GoTerm","value":"C:external side of plasma membrane"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"6777381"}]},{"database":"GO","id":"GO:0070062","properties":[{"key":"GoTerm","value":"C:extracellular exosome"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"23533145"}]},{"database":"GO","id":"GO:0031012","properties":[{"key":"GoTerm","value":"C:extracellular matrix"},{"key":"GoEvidenceType","value":"HDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"25037231"},{"evidenceCode":"ECO:0007005","source":"PubMed","id":"28327460"},{"evidenceCode":"ECO:0007005","source":"PubMed","id":"28344315"},{"evidenceCode":"ECO:0007005","source":"PubMed","id":"28675934"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19996109"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"6777381"}]},{"database":"GO","id":"GO:1903561","properties":[{"key":"GoTerm","value":"C:extracellular vesicle"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"24769233"}]},{"database":"GO","id":"GO:0005577","properties":[{"key":"GoTerm","value":"C:fibrinogen complex"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16846481"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18676163"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"6688356"}]},{"database":"GO","id":"GO:0140144","properties":[{"key":"GoTerm","value":"C:non-collagenous component of basement membrane"},{"key":"GoEvidenceType","value":"TAS:GO_Central"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"36399478"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0031091","properties":[{"key":"GoTerm","value":"C:platelet alpha granule"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"6777381"}]},{"database":"GO","id":"GO:0031093","properties":[{"key":"GoTerm","value":"C:platelet alpha granule lumen"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0045202","properties":[{"key":"GoTerm","value":"C:synapse"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0005201","properties":[{"key":"GoTerm","value":"F:extracellular matrix structural constituent"},{"key":"GoEvidenceType","value":"HDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"28344315"}]},{"database":"GO","id":"GO:0051087","properties":[{"key":"GoTerm","value":"F:protein-folding chaperone binding"},{"key":"GoEvidenceType","value":"IPI:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"19996109"}]},{"database":"GO","id":"GO:0005102","properties":[{"key":"GoTerm","value":"F:signaling receptor binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0005198","properties":[{"key":"GoTerm","value":"F:structural molecule activity"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"8910396"}]},{"database":"GO","id":"GO:0072378","properties":[{"key":"GoTerm","value":"P:blood coagulation, fibrin clot formation"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16846481"}]},{"database":"GO","id":"GO:0007160","properties":[{"key":"GoTerm","value":"P:cell-matrix adhesion"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10903502"}]},{"database":"GO","id":"GO:0071347","properties":[{"key":"GoTerm","value":"P:cellular response to interleukin-1"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0044320","properties":[{"key":"GoTerm","value":"P:cellular response to leptin stimulus"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0042730","properties":[{"key":"GoTerm","value":"P:fibrinolysis"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16846481"}]},{"database":"GO","id":"GO:0043152","properties":[{"key":"GoTerm","value":"P:induction of bacterial agglutination"},{"key":"GoEvidenceType","value":"IDA:CACAO"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24367264"}]},{"database":"GO","id":"GO:2000352","properties":[{"key":"GoTerm","value":"P:negative regulation of endothelial cell apoptotic process"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10903502"}]},{"database":"GO","id":"GO:1902042","properties":[{"key":"GoTerm","value":"P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10903502"}]},{"database":"GO","id":"GO:0031639","properties":[{"key":"GoTerm","value":"P:plasminogen activation"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16846481"}]},{"database":"GO","id":"GO:0070527","properties":[{"key":"GoTerm","value":"P:platelet aggregation"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"6281794"}]},{"database":"GO","id":"GO:0070374","properties":[{"key":"GoTerm","value":"P:positive regulation of ERK1 and ERK2 cascade"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10903502"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19193866"}]},{"database":"GO","id":"GO:0045921","properties":[{"key":"GoTerm","value":"P:positive regulation of exocytosis"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19193866"}]},{"database":"GO","id":"GO:0034116","properties":[{"key":"GoTerm","value":"P:positive regulation of heterotypic cell-cell adhesion"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"8100742"}]},{"database":"GO","id":"GO:0090277","properties":[{"key":"GoTerm","value":"P:positive regulation of peptide hormone secretion"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19193866"}]},{"database":"GO","id":"GO:0050714","properties":[{"key":"GoTerm","value":"P:positive regulation of protein secretion"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19193866"}]},{"database":"GO","id":"GO:1900026","properties":[{"key":"GoTerm","value":"P:positive regulation of substrate adhesion-dependent cell spreading"},{"key":"GoEvidenceType","value":"NAS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"24041635"}]},{"database":"GO","id":"GO:0045907","properties":[{"key":"GoTerm","value":"P:positive regulation of vasoconstriction"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15739255"}]},{"database":"GO","id":"GO:0051258","properties":[{"key":"GoTerm","value":"P:protein polymerization"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12706644"}]},{"database":"GO","id":"GO:0065003","properties":[{"key":"GoTerm","value":"P:protein-containing complex assembly"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"8910396"}]},{"database":"GO","id":"GO:0051592","properties":[{"key":"GoTerm","value":"P:response to calcium ion"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"6777381"}]},{"database":"CDD","id":"cd00087","properties":[{"key":"EntryName","value":"FReD"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.5.50:FF:000004","properties":[{"key":"EntryName","value":"Fibrinogen beta chain"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.215.10:FF:000006","properties":[{"key":"EntryName","value":"Fibrinogen beta chain"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"4.10.530.10:FF:000004","properties":[{"key":"EntryName","value":"Fibrinogen beta chain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.5.50","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"3.90.215.10","properties":[{"key":"EntryName","value":"Gamma Fibrinogen, chain A, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR037579","properties":[{"key":"EntryName","value":"FIB_ANG-like"}]},{"database":"InterPro","id":"IPR036056","properties":[{"key":"EntryName","value":"Fibrinogen-like_C"}]},{"database":"InterPro","id":"IPR014716","properties":[{"key":"EntryName","value":"Fibrinogen_a/b/g_C_1"}]},{"database":"InterPro","id":"IPR002181","properties":[{"key":"EntryName","value":"Fibrinogen_a/b/g_C_dom"}]},{"database":"InterPro","id":"IPR012290","properties":[{"key":"EntryName","value":"Fibrinogen_a/b/g_coil_dom"}]},{"database":"InterPro","id":"IPR020837","properties":[{"key":"EntryName","value":"Fibrinogen_CS"}]},{"database":"NCBIfam","id":"NF040941","properties":[{"key":"EntryName","value":"GGGWT_bact"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR47221","properties":[{"key":"EntryName","value":"FIBRINOGEN ALPHA CHAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR47221:SF5","properties":[{"key":"EntryName","value":"FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08702","properties":[{"key":"EntryName","value":"Fib_alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00147","properties":[{"key":"EntryName","value":"Fibrinogen_C"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00186","properties":[{"key":"EntryName","value":"FBG"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM01212","properties":[{"key":"EntryName","value":"Fib_alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56496","properties":[{"key":"EntryName","value":"Fibrinogen C-terminal domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF58010","properties":[{"key":"EntryName","value":"Fibrinogen coiled-coil and central regions"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00514","properties":[{"key":"EntryName","value":"FIBRINOGEN_C_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51406","properties":[{"key":"EntryName","value":"FIBRINOGEN_C_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MKRMVSWSFHKLKTMKHLLLLLLCVFLVKSQGVNDNEEGFFSARGHRPLDKKREEAPSLRPAPPPISGGGYRARPAKAAATQKKVERKAPDAGGCLHADPDLGVLCPTGCQLQEALLQQERPIRNSVDELNNNVEAVSQTSSSSFQYMYLLKDLWQKRQKQVKDNENVVNEYSSELEKHQLYIDETVNSNIPTNLRVLRSILENLRSKIQKLESDVSAQMEYCRTPCTVSCNIPVVSGKECEEIIRKGGETSEMYLIQPDSSVKPYRVYCDMNTENGGWTVIQNRQDGSVDFGRKWDPYKQGFGNVATNTDGKNYCGLPGEYWLGNDKISQLTRMGPTELLIEMEDWKGDKVKAHYGGFTVQNEANKYQISVNKYRGTAGNALMDGASQLMGENRTMTIHNGMFFSTYDRDNDGWLTSDPRKQCSKEDGGGWWYNRCHAANPNGRYYWGGQYTWDMAKHGTDDGVVWMNWKGSWYSMRKMSMKIRPFFPQQ","length":491,"molWeight":55928,"crc64":"B92FFB9976AB53C5","md5":"65B4414413493471074BD11FE9E01B24"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"INTERACTION":1,"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1,"DOMAIN":1,"PTM":1,"DISEASE":2,"SEQUENCE CAUTION":1,"WEB RESOURCE":1},"countByFeatureType":{"Signal":1,"Peptide":1,"Chain":1,"Domain":1,"Region":2,"Coiled coil":1,"Compositional bias":1,"Site":4,"Modified residue":1,"Glycosylation":1,"Disulfide bond":8,"Natural variant":17,"Sequence conflict":4,"Helix":18,"Turn":4,"Beta strand":25},"uniParcId":"UPI000012A778"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"V9HVY1","uniProtkbId":"V9HVY1_HUMAN","entryAudit":{"firstPublicDate":"2014-03-19","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2014-03-19","entryVersion":76,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACF94486.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00016534"}],"value":"Fibrinogen beta chain"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACF94486.1"}],"value":"HEL-S-78p"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WMT11014.1"}],"value":"FGB"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00055482"}],"value":"Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00025974"}],"value":"Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004613"}],"value":"Secreted","id":"SL-0243"}}]}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":30,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":31,"modifier":"EXACT"},"end":{"value":491,"modifier":"EXACT"}},"description":"Fibrinogen beta chain","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5048134429"},{"type":"Domain","location":{"start":{"value":232,"modifier":"EXACT"},"end":{"value":488,"modifier":"EXACT"}},"description":"Fibrinogen C-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51406"}]},{"type":"Region","location":{"start":{"value":44,"modifier":"EXACT"},"end":{"value":75,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":195,"modifier":"EXACT"},"end":{"value":222,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Compositional bias","location":{"start":{"value":47,"modifier":"EXACT"},"end":{"value":57,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Disulfide bond","location":{"start":{"value":241,"modifier":"EXACT"},"end":{"value":270,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00739"}]},{"type":"Disulfide bond","location":{"start":{"value":424,"modifier":"EXACT"},"end":{"value":437,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00739"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023130"}],"id":"KW-1064","category":"Biological process","name":"Adaptive immunity"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023084"}],"id":"KW-0094","category":"Biological process","name":"Blood coagulation"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023054"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00739"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022696"}],"id":"KW-0356","category":"Biological process","name":"Hemostasis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022859"}],"id":"KW-0391","category":"Biological process","name":"Immunity"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022588"}],"id":"KW-0399","category":"Biological process","name":"Innate immunity"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-FEI8Q699IA9VB","citationType":"submission","authors":["Li J.Y.","Wang H.Y.","Liu F.J.","Liu J."],"publicationDate":"APR-2008","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACF94486.1"}]},{"referenceNumber":2,"citation":{"id":"CI-6J6DH46TOONVJ","citationType":"submission","authors":["Liu H.","Li X.","Dai X.","Zhu F."],"publicationDate":"JUN-2023","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WMT11014.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"EU668333","properties":[{"key":"ProteinId","value":"ACF94486.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"OR234395","properties":[{"key":"ProteinId","value":"WMT11014.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"RefSeq","id":"NP_005132.2","properties":[{"key":"NucleotideSequenceId","value":"NM_005141.5"}]},{"database":"AlphaFoldDB","id":"V9HVY1","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"V9HVY1","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"855","properties":[{"key":"antibodies","value":"636 antibodies from 40 providers"}]},{"database":"DNASU","id":"2244","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"2244","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:2244","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc003ioa.5","properties":[{"key":"OrganismName","value":"human"}]},{"database":"CTD","id":"2244","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"2244","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000171564","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_038628_13_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"GCIHADP","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9930906at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"V9HVY1","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"2244","properties":[{"key":"hits","value":"15 hits in 1148 CRISPR screens"}]},{"database":"ChiTaRS","id":"FGB","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GO","id":"GO:0072562","properties":[{"key":"GoTerm","value":"C:blood microparticle"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0005938","properties":[{"key":"GoTerm","value":"C:cell cortex"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0005783","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005577","properties":[{"key":"GoTerm","value":"C:fibrinogen complex"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0045202","properties":[{"key":"GoTerm","value":"C:synapse"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0005102","properties":[{"key":"GoTerm","value":"F:signaling receptor binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0071347","properties":[{"key":"GoTerm","value":"P:cellular response to interleukin-1"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0044320","properties":[{"key":"GoTerm","value":"P:cellular response to leptin stimulus"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0030168","properties":[{"key":"GoTerm","value":"P:platelet activation"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0051258","properties":[{"key":"GoTerm","value":"P:protein polymerization"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd00087","properties":[{"key":"EntryName","value":"FReD"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.5.50:FF:000004","properties":[{"key":"EntryName","value":"Fibrinogen beta chain"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.215.10:FF:000006","properties":[{"key":"EntryName","value":"Fibrinogen beta chain"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"4.10.530.10:FF:000004","properties":[{"key":"EntryName","value":"Fibrinogen beta chain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.5.50","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"3.90.215.10","properties":[{"key":"EntryName","value":"Gamma Fibrinogen, chain A, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR037579","properties":[{"key":"EntryName","value":"FIB_ANG-like"}]},{"database":"InterPro","id":"IPR036056","properties":[{"key":"EntryName","value":"Fibrinogen-like_C"}]},{"database":"InterPro","id":"IPR014716","properties":[{"key":"EntryName","value":"Fibrinogen_a/b/g_C_1"}]},{"database":"InterPro","id":"IPR002181","properties":[{"key":"EntryName","value":"Fibrinogen_a/b/g_C_dom"}]},{"database":"InterPro","id":"IPR012290","properties":[{"key":"EntryName","value":"Fibrinogen_a/b/g_coil_dom"}]},{"database":"InterPro","id":"IPR020837","properties":[{"key":"EntryName","value":"Fibrinogen_CS"}]},{"database":"NCBIfam","id":"NF040941","properties":[{"key":"EntryName","value":"GGGWT_bact"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR47221","properties":[{"key":"EntryName","value":"FIBRINOGEN ALPHA CHAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR47221:SF5","properties":[{"key":"EntryName","value":"FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08702","properties":[{"key":"EntryName","value":"Fib_alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00147","properties":[{"key":"EntryName","value":"Fibrinogen_C"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00186","properties":[{"key":"EntryName","value":"FBG"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM01212","properties":[{"key":"EntryName","value":"Fib_alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56496","properties":[{"key":"EntryName","value":"Fibrinogen C-terminal domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF58010","properties":[{"key":"EntryName","value":"Fibrinogen coiled-coil and central regions"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00514","properties":[{"key":"EntryName","value":"FIBRINOGEN_C_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51406","properties":[{"key":"EntryName","value":"FIBRINOGEN_C_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MKRMVSWSFHKLKTMKHLLLLLLCVFLVKSQGVNDNEEGFFSARGHRPLDKKREEAPSLRPAPPPISGGGYRARPAKAAATQKKVERKAPDAGGCLHADPDLGVLCPTGCQLQEALLQQERPIRNSVDELNNNVEAVSQTSSSSFQYMYLLKDLWQKRQKQVKDNENVVNEYSSELEKHQLYIDETVNSNIPTNLRVLRSILENLRSKIQKLESDVSAQMEYCRTPCTVSCNIPVVSGKECEEIIRKGGETSEMYLIQPDSSVKPYRVYCDMNTENGGWTVIQNRQDGSVDFGRKWDPYKQGFGNVATNTDGKNYCGLPGEYWLGNDKISQLTRMGPTELLIEMEDWKGDKVKAHYGGFTVQNEANKYQISVNKYRGTAGNALMDGASQLMGENRTMTIHNGMFFSTYDRDNDGWLTSDPRKQCSKEDGGGWWYNRCHAANPNGRYYWGGQYTWDMAKHGTDDGVVWMNWKGSWYSMRKMSMKIRPFFPQQ","length":491,"molWeight":55928,"crc64":"B92FFB9976AB53C5","md5":"65B4414413493471074BD11FE9E01B24"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":1,"Region":1,"Coiled coil":1,"Compositional bias":1,"Disulfide bond":2},"uniParcId":"UPI000012A778"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8S821","uniProtkbId":"A0ACI8S821_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000575005.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00016534"}],"value":"Fibrinogen beta chain"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000575005.1"}],"value":"FGB"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00025974"}],"value":"Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004613"}],"value":"Secreted","id":"SL-0243"}}]}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":30,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":31,"modifier":"EXACT"},"end":{"value":472,"modifier":"EXACT"}},"description":"Fibrinogen beta chain","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5051525095"},{"type":"Domain","location":{"start":{"value":232,"modifier":"EXACT"},"end":{"value":469,"modifier":"EXACT"}},"description":"Fibrinogen C-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51406"}]},{"type":"Region","location":{"start":{"value":44,"modifier":"EXACT"},"end":{"value":75,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":195,"modifier":"EXACT"},"end":{"value":222,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Compositional bias","location":{"start":{"value":47,"modifier":"EXACT"},"end":{"value":57,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Disulfide bond","location":{"start":{"value":241,"modifier":"EXACT"},"end":{"value":270,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00739"}]},{"type":"Disulfide bond","location":{"start":{"value":405,"modifier":"EXACT"},"end":{"value":418,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00739"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023084"}],"id":"KW-0094","category":"Biological process","name":"Blood coagulation"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023054"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00739"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022696"}],"id":"KW-0356","category":"Biological process","name":"Hemostasis"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8S821"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8S821"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000575005.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000575005.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15815621","citationType":"journal article","authors":["Hillier L.W.","Graves T.A.","Fulton R.S.","Fulton L.A.","Pepin K.H.","Minx P.","Wagner-McPherson C.","Layman D.","Wylie K.","Sekhon M.","Becker M.C.","Fewell G.A.","Delehaunty K.D.","Miner T.L.","Nash W.E.","Kremitzki C.","Oddy L.","Du H.","Sun H.","Bradshaw-Cordum H.","Ali J.","Carter J.","Cordes M.","Harris A.","Isak A.","van Brunt A.","Nguyen C.","Du F.","Courtney L.","Kalicki J.","Ozersky P.","Abbott S.","Armstrong J.","Belter E.A.","Caruso L.","Cedroni M.","Cotton M.","Davidson T.","Desai A.","Elliott G.","Erb T.","Fronick C.","Gaige T.","Haakenson W.","Haglund K.","Holmes A.","Harkins R.","Kim K.","Kruchowski S.S.","Strong C.M.","Grewal N.","Goyea E.","Hou S.","Levy A.","Martinka S.","Mead K.","McLellan M.D.","Meyer R.","Randall-Maher J.","Tomlinson C.","Dauphin-Kohlberg S.","Kozlowicz-Reilly A.","Shah N.","Swearengen-Shahid S.","Snider J.","Strong J.T.","Thompson J.","Yoakum M.","Leonard S.","Pearman C.","Trani L.","Radionenko M.","Waligorski J.E.","Wang C.","Rock S.M.","Tin-Wollam A.M.","Maupin R.","Latreille P.","Wendl M.C.","Yang S.P.","Pohl C.","Wallis J.W.","Spieth J.","Bieri T.A.","Berkowicz N.","Nelson J.O.","Osborne J.","Ding L.","Meyer R.","Sabo A.","Shotland Y.","Sinha P.","Wohldmann P.E.","Cook L.L.","Hickenbotham M.T.","Eldred J.","Williams D.","Jones T.A.","She X.","Ciccarelli F.D.","Izaurralde E.","Taylor J.","Schmutz J.","Myers R.M.","Cox D.R.","Huang X.","McPherson J.D.","Mardis E.R.","Clifton S.W.","Warren W.C.","Chinwalla A.T.","Eddy S.R.","Marra M.A.","Ovcharenko I.","Furey T.S.","Miller W.","Eichler E.E.","Bork P.","Suyama M.","Torrents D.","Waterston R.H.","Wilson R.K."],"citationCrossReferences":[{"database":"PubMed","id":"15815621"},{"database":"DOI","id":"10.1038/nature03466"}],"title":"Generation and annotation of the DNA sequences of human chromosomes 2 and 4.","publicationDate":"2005","journal":"Nature","firstPage":"724","lastPage":"731","volume":"434"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000575005.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000575005.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC107385","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000904946.1","properties":[{"key":"ProteinId","value":"ENSP00000575005.1"},{"key":"GeneId","value":"ENSG00000171564.13"}]},{"database":"HGNC","id":"HGNC:3662","properties":[{"key":"GeneName","value":"FGB"}]},{"database":"OpenTargets","id":"ENSG00000171564","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000158122","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 4"}]},{"database":"CDD","id":"cd00087","properties":[{"key":"EntryName","value":"FReD"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.5.50:FF:000004","properties":[{"key":"EntryName","value":"Fibrinogen beta chain"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"4.10.530.10:FF:000004","properties":[{"key":"EntryName","value":"Fibrinogen beta chain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.5.50","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"3.90.215.10","properties":[{"key":"EntryName","value":"Gamma Fibrinogen, chain A, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR037579","properties":[{"key":"EntryName","value":"FIB_ANG-like"}]},{"database":"InterPro","id":"IPR036056","properties":[{"key":"EntryName","value":"Fibrinogen-like_C"}]},{"database":"InterPro","id":"IPR014716","properties":[{"key":"EntryName","value":"Fibrinogen_a/b/g_C_1"}]},{"database":"InterPro","id":"IPR002181","properties":[{"key":"EntryName","value":"Fibrinogen_a/b/g_C_dom"}]},{"database":"InterPro","id":"IPR012290","properties":[{"key":"EntryName","value":"Fibrinogen_a/b/g_coil_dom"}]},{"database":"InterPro","id":"IPR020837","properties":[{"key":"EntryName","value":"Fibrinogen_CS"}]},{"database":"NCBIfam","id":"NF040941","properties":[{"key":"EntryName","value":"GGGWT_bact"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR47221","properties":[{"key":"EntryName","value":"FIBRINOGEN ALPHA CHAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR47221:SF5","properties":[{"key":"EntryName","value":"FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08702","properties":[{"key":"EntryName","value":"Fib_alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00147","properties":[{"key":"EntryName","value":"Fibrinogen_C"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00186","properties":[{"key":"EntryName","value":"FBG"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM01212","properties":[{"key":"EntryName","value":"Fib_alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56496","properties":[{"key":"EntryName","value":"Fibrinogen C-terminal domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF58010","properties":[{"key":"EntryName","value":"Fibrinogen coiled-coil and central regions"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00514","properties":[{"key":"EntryName","value":"FIBRINOGEN_C_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51406","properties":[{"key":"EntryName","value":"FIBRINOGEN_C_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MKRMVSWSFHKLKTMKHLLLLLLCVFLVKSQGVNDNEEGFFSARGHRPLDKKREEAPSLRPAPPPISGGGYRARPAKAAATQKKVERKAPDAGGCLHADPDLGVLCPTGCQLQEALLQQERPIRNSVDELNNNVEAVSQTSSSSFQYMYLLKDLWQKRQKQVKDNENVVNEYSSELEKHQLYIDETVNSNIPTNLRVLRSILENLRSKIQKLESDVSAQMEYCRTPCTVSCNIPVVSGKECEEIIRKGGETSEMYLIQPDSSVKPYRVYCDMNTENGGWTVIQNRQDGSVDFGRKWDPYKQGFGNVATNTDGKNYCGLPELLIEMEDWKGDKVKAHYGGFTVQNEANKYQISVNKYRGTAGNALMDGASQLMGENRTMTIHNGMFFSTYDRDNDGWLTSDPRKQCSKEDGGGWWYNRCHAANPNGRYYWGGQYTWDMAKHGTDDGVVWMNWKGSWYSMRKMSMKIRPFFPQQ","length":472,"molWeight":53780,"crc64":"4BD5FCC8169D63FB","md5":"71BBC6526C3A34627D332DA03B107657"},"extraAttributes":{"countByCommentType":{"SUBUNIT":1,"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":1,"Region":1,"Coiled coil":1,"Compositional bias":1,"Disulfide bond":2},"uniParcId":"UPI0040317B1D"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8SD32","uniProtkbId":"A0ACI8SD32_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000575001.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00016534"}],"value":"Fibrinogen beta chain"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000575001.1"}],"value":"FGB"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00025974"}],"value":"Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004613"}],"value":"Secreted","id":"SL-0243"}}]}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":30,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":31,"modifier":"EXACT"},"end":{"value":488,"modifier":"EXACT"}},"description":"Fibrinogen beta chain","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5051414111"},{"type":"Domain","location":{"start":{"value":232,"modifier":"EXACT"},"end":{"value":485,"modifier":"EXACT"}},"description":"Fibrinogen C-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51406"}]},{"type":"Region","location":{"start":{"value":44,"modifier":"EXACT"},"end":{"value":76,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":195,"modifier":"EXACT"},"end":{"value":222,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Compositional bias","location":{"start":{"value":47,"modifier":"EXACT"},"end":{"value":57,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Disulfide bond","location":{"start":{"value":241,"modifier":"EXACT"},"end":{"value":270,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00739"}]},{"type":"Disulfide bond","location":{"start":{"value":421,"modifier":"EXACT"},"end":{"value":434,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00739"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023130"}],"id":"KW-1064","category":"Biological process","name":"Adaptive immunity"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023084"}],"id":"KW-0094","category":"Biological process","name":"Blood coagulation"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023054"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00739"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022696"}],"id":"KW-0356","category":"Biological process","name":"Hemostasis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022859"}],"id":"KW-0391","category":"Biological process","name":"Immunity"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022588"}],"id":"KW-0399","category":"Biological process","name":"Innate immunity"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8SD32"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8SD32"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000575001.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000575001.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15815621","citationType":"journal article","authors":["Hillier L.W.","Graves T.A.","Fulton R.S.","Fulton L.A.","Pepin K.H.","Minx P.","Wagner-McPherson C.","Layman D.","Wylie K.","Sekhon M.","Becker M.C.","Fewell G.A.","Delehaunty K.D.","Miner T.L.","Nash W.E.","Kremitzki C.","Oddy L.","Du H.","Sun H.","Bradshaw-Cordum H.","Ali J.","Carter J.","Cordes M.","Harris A.","Isak A.","van Brunt A.","Nguyen C.","Du F.","Courtney L.","Kalicki J.","Ozersky P.","Abbott S.","Armstrong J.","Belter E.A.","Caruso L.","Cedroni M.","Cotton M.","Davidson T.","Desai A.","Elliott G.","Erb T.","Fronick C.","Gaige T.","Haakenson W.","Haglund K.","Holmes A.","Harkins R.","Kim K.","Kruchowski S.S.","Strong C.M.","Grewal N.","Goyea E.","Hou S.","Levy A.","Martinka S.","Mead K.","McLellan M.D.","Meyer R.","Randall-Maher J.","Tomlinson C.","Dauphin-Kohlberg S.","Kozlowicz-Reilly A.","Shah N.","Swearengen-Shahid S.","Snider J.","Strong J.T.","Thompson J.","Yoakum M.","Leonard S.","Pearman C.","Trani L.","Radionenko M.","Waligorski J.E.","Wang C.","Rock S.M.","Tin-Wollam A.M.","Maupin R.","Latreille P.","Wendl M.C.","Yang S.P.","Pohl C.","Wallis J.W.","Spieth J.","Bieri T.A.","Berkowicz N.","Nelson J.O.","Osborne J.","Ding L.","Meyer R.","Sabo A.","Shotland Y.","Sinha P.","Wohldmann P.E.","Cook L.L.","Hickenbotham M.T.","Eldred J.","Williams D.","Jones T.A.","She X.","Ciccarelli F.D.","Izaurralde E.","Taylor J.","Schmutz J.","Myers R.M.","Cox D.R.","Huang X.","McPherson J.D.","Mardis E.R.","Clifton S.W.","Warren W.C.","Chinwalla A.T.","Eddy S.R.","Marra M.A.","Ovcharenko I.","Furey T.S.","Miller W.","Eichler E.E.","Bork P.","Suyama M.","Torrents D.","Waterston R.H.","Wilson R.K."],"citationCrossReferences":[{"database":"PubMed","id":"15815621"},{"database":"DOI","id":"10.1038/nature03466"}],"title":"Generation and annotation of the DNA sequences of human chromosomes 2 and 4.","publicationDate":"2005","journal":"Nature","firstPage":"724","lastPage":"731","volume":"434"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000575001.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000575001.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC107385","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"NP_001369692.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001382763.1"}]},{"database":"Ensembl","id":"ENST00000904942.1","properties":[{"key":"ProteinId","value":"ENSP00000575001.1"},{"key":"GeneId","value":"ENSG00000171564.13"}]},{"database":"GeneID","id":"2244","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:3662","properties":[{"key":"GeneName","value":"FGB"}]},{"database":"OpenTargets","id":"ENSG00000171564","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000158122","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 4"}]},{"database":"CDD","id":"cd00087","properties":[{"key":"EntryName","value":"FReD"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.5.50:FF:000004","properties":[{"key":"EntryName","value":"Fibrinogen beta chain"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.215.10:FF:000006","properties":[{"key":"EntryName","value":"Fibrinogen beta chain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.5.50","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"3.90.215.10","properties":[{"key":"EntryName","value":"Gamma Fibrinogen, chain A, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR037579","properties":[{"key":"EntryName","value":"FIB_ANG-like"}]},{"database":"InterPro","id":"IPR036056","properties":[{"key":"EntryName","value":"Fibrinogen-like_C"}]},{"database":"InterPro","id":"IPR014716","properties":[{"key":"EntryName","value":"Fibrinogen_a/b/g_C_1"}]},{"database":"InterPro","id":"IPR002181","properties":[{"key":"EntryName","value":"Fibrinogen_a/b/g_C_dom"}]},{"database":"InterPro","id":"IPR012290","properties":[{"key":"EntryName","value":"Fibrinogen_a/b/g_coil_dom"}]},{"database":"InterPro","id":"IPR020837","properties":[{"key":"EntryName","value":"Fibrinogen_CS"}]},{"database":"PANTHER","id":"PTHR47221","properties":[{"key":"EntryName","value":"FIBRINOGEN ALPHA CHAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR47221:SF5","properties":[{"key":"EntryName","value":"FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08702","properties":[{"key":"EntryName","value":"Fib_alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00147","properties":[{"key":"EntryName","value":"Fibrinogen_C"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00186","properties":[{"key":"EntryName","value":"FBG"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM01212","properties":[{"key":"EntryName","value":"Fib_alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56496","properties":[{"key":"EntryName","value":"Fibrinogen C-terminal domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF58010","properties":[{"key":"EntryName","value":"Fibrinogen coiled-coil and central regions"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00514","properties":[{"key":"EntryName","value":"FIBRINOGEN_C_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51406","properties":[{"key":"EntryName","value":"FIBRINOGEN_C_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MKRMVSWSFHKLKTMKHLLLLLLCVFLVKSQGVNDNEEGFFSARGHRPLDKKREEAPSLRPAPPPISGGGYRARPAKAAATQKKVERKAPDAGGCLHADPDLGVLCPTGCQLQEALLQQERPIRNSVDELNNNVEAVSQTSSSSFQYMYLLKDLWQKRQKQVKDNENVVNEYSSELEKHQLYIDETVNSNIPTNLRVLRSILENLRSKIQKLESDVSAQMEYCRTPCTVSCNIPVVSGKECEEIIRKGGETSEMYLIQPDSSVKPYRVYCDMNTENGVIQNRQDGSVDFGRKWDPYKQGFGNVATNTDGKNYCGLPGEYWLGNDKISQLTRMGPTELLIEMEDWKGDKVKAHYGGFTVQNEANKYQISVNKYRGTAGNALMDGASQLMGENRTMTIHNGMFFSTYDRDNDGWLTSDPRKQCSKEDGGGWWYNRCHAANPNGRYYWGGQYTWDMAKHGTDDGVVWMNWKGSWYSMRKMSMKIRPFFPQQ","length":488,"molWeight":55584,"crc64":"4F09F52479EA5340","md5":"0491F45434F409F188107B5FB6FE3DCF"},"extraAttributes":{"countByCommentType":{"SUBUNIT":1,"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":1,"Region":1,"Coiled coil":1,"Compositional bias":1,"Disulfide bond":2},"uniParcId":"UPI00148C20F7"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8R0S8","uniProtkbId":"A0ACI8R0S8_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000575000.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000575000.1"}],"value":"Fibrinogen beta chain"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000575000.1"}],"value":"FGB"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00025974"}],"value":"Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004613"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00739"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":30,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":31,"modifier":"EXACT"},"end":{"value":411,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5051542812"},{"type":"Domain","location":{"start":{"value":232,"modifier":"EXACT"},"end":{"value":278,"modifier":"EXACT"}},"description":"Fibrinogen C-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51406"}]},{"type":"Domain","location":{"start":{"value":279,"modifier":"EXACT"},"end":{"value":408,"modifier":"EXACT"}},"description":"Fibrinogen C-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51406"}]},{"type":"Region","location":{"start":{"value":44,"modifier":"EXACT"},"end":{"value":75,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":195,"modifier":"EXACT"},"end":{"value":222,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Compositional bias","location":{"start":{"value":47,"modifier":"EXACT"},"end":{"value":57,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Disulfide bond","location":{"start":{"value":241,"modifier":"EXACT"},"end":{"value":270,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00739"}]},{"type":"Disulfide bond","location":{"start":{"value":344,"modifier":"EXACT"},"end":{"value":357,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00739"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023084"}],"id":"KW-0094","category":"Biological process","name":"Blood coagulation"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023054"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00739"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022696"}],"id":"KW-0356","category":"Biological process","name":"Hemostasis"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8R0S8"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8R0S8"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000575000.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000575000.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15815621","citationType":"journal article","authors":["Hillier L.W.","Graves T.A.","Fulton R.S.","Fulton L.A.","Pepin K.H.","Minx P.","Wagner-McPherson C.","Layman D.","Wylie K.","Sekhon M.","Becker M.C.","Fewell G.A.","Delehaunty K.D.","Miner T.L.","Nash W.E.","Kremitzki C.","Oddy L.","Du H.","Sun H.","Bradshaw-Cordum H.","Ali J.","Carter J.","Cordes M.","Harris A.","Isak A.","van Brunt A.","Nguyen C.","Du F.","Courtney L.","Kalicki J.","Ozersky P.","Abbott S.","Armstrong J.","Belter E.A.","Caruso L.","Cedroni M.","Cotton M.","Davidson T.","Desai A.","Elliott G.","Erb T.","Fronick C.","Gaige T.","Haakenson W.","Haglund K.","Holmes A.","Harkins R.","Kim K.","Kruchowski S.S.","Strong C.M.","Grewal N.","Goyea E.","Hou S.","Levy A.","Martinka S.","Mead K.","McLellan M.D.","Meyer R.","Randall-Maher J.","Tomlinson C.","Dauphin-Kohlberg S.","Kozlowicz-Reilly A.","Shah N.","Swearengen-Shahid S.","Snider J.","Strong J.T.","Thompson J.","Yoakum M.","Leonard S.","Pearman C.","Trani L.","Radionenko M.","Waligorski J.E.","Wang C.","Rock S.M.","Tin-Wollam A.M.","Maupin R.","Latreille P.","Wendl M.C.","Yang S.P.","Pohl C.","Wallis J.W.","Spieth J.","Bieri T.A.","Berkowicz N.","Nelson J.O.","Osborne J.","Ding L.","Meyer R.","Sabo A.","Shotland Y.","Sinha P.","Wohldmann P.E.","Cook L.L.","Hickenbotham M.T.","Eldred J.","Williams D.","Jones T.A.","She X.","Ciccarelli F.D.","Izaurralde E.","Taylor J.","Schmutz J.","Myers R.M.","Cox D.R.","Huang X.","McPherson J.D.","Mardis E.R.","Clifton S.W.","Warren W.C.","Chinwalla A.T.","Eddy S.R.","Marra M.A.","Ovcharenko I.","Furey T.S.","Miller W.","Eichler E.E.","Bork P.","Suyama M.","Torrents D.","Waterston R.H.","Wilson R.K."],"citationCrossReferences":[{"database":"PubMed","id":"15815621"},{"database":"DOI","id":"10.1038/nature03466"}],"title":"Generation and annotation of the DNA sequences of human chromosomes 2 and 4.","publicationDate":"2005","journal":"Nature","firstPage":"724","lastPage":"731","volume":"434"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000575000.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000575000.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC107385","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000904941.1","properties":[{"key":"ProteinId","value":"ENSP00000575000.1"},{"key":"GeneId","value":"ENSG00000171564.13"}]},{"database":"HGNC","id":"HGNC:3662","properties":[{"key":"GeneName","value":"FGB"}]},{"database":"OpenTargets","id":"ENSG00000171564","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000158122","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 4"}]},{"database":"FunFam","id":"1.20.5.50:FF:000004","properties":[{"key":"EntryName","value":"Fibrinogen beta chain"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"4.10.530.10:FF:000004","properties":[{"key":"EntryName","value":"Fibrinogen beta chain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.5.50","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"3.90.215.10","properties":[{"key":"EntryName","value":"Gamma Fibrinogen, chain A, domain 1"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"4.10.530.10","properties":[{"key":"EntryName","value":"Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR037579","properties":[{"key":"EntryName","value":"FIB_ANG-like"}]},{"database":"InterPro","id":"IPR036056","properties":[{"key":"EntryName","value":"Fibrinogen-like_C"}]},{"database":"InterPro","id":"IPR014716","properties":[{"key":"EntryName","value":"Fibrinogen_a/b/g_C_1"}]},{"database":"InterPro","id":"IPR002181","properties":[{"key":"EntryName","value":"Fibrinogen_a/b/g_C_dom"}]},{"database":"InterPro","id":"IPR012290","properties":[{"key":"EntryName","value":"Fibrinogen_a/b/g_coil_dom"}]},{"database":"InterPro","id":"IPR020837","properties":[{"key":"EntryName","value":"Fibrinogen_CS"}]},{"database":"NCBIfam","id":"NF040941","properties":[{"key":"EntryName","value":"GGGWT_bact"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR47221","properties":[{"key":"EntryName","value":"FIBRINOGEN ALPHA CHAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR47221:SF6","properties":[{"key":"EntryName","value":"FIBRINOGEN ALPHA CHAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08702","properties":[{"key":"EntryName","value":"Fib_alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00147","properties":[{"key":"EntryName","value":"Fibrinogen_C"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00186","properties":[{"key":"EntryName","value":"FBG"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM01212","properties":[{"key":"EntryName","value":"Fib_alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56496","properties":[{"key":"EntryName","value":"Fibrinogen C-terminal domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF58010","properties":[{"key":"EntryName","value":"Fibrinogen coiled-coil and central regions"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00514","properties":[{"key":"EntryName","value":"FIBRINOGEN_C_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51406","properties":[{"key":"EntryName","value":"FIBRINOGEN_C_2"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MKRMVSWSFHKLKTMKHLLLLLLCVFLVKSQGVNDNEEGFFSARGHRPLDKKREEAPSLRPAPPPISGGGYRARPAKAAATQKKVERKAPDAGGCLHADPDLGVLCPTGCQLQEALLQQERPIRNSVDELNNNVEAVSQTSSSSFQYMYLLKDLWQKRQKQVKDNENVVNEYSSELEKHQLYIDETVNSNIPTNLRVLRSILENLRSKIQKLESDVSAQMEYCRTPCTVSCNIPVVSGKECEEIIRKGGETSEMYLIQPDSSVKPYRVYCDMNTENGGFTVQNEANKYQISVNKYRGTAGNALMDGASQLMGENRTMTIHNGMFFSTYDRDNDGWLTSDPRKQCSKEDGGGWWYNRCHAANPNGRYYWGGQYTWDMAKHGTDDGVVWMNWKGSWYSMRKMSMKIRPFFPQQ","length":411,"molWeight":46863,"crc64":"185B732B9F56ABB4","md5":"3AE5C1F9E061257D6CC6D971344D6C25"},"extraAttributes":{"countByCommentType":{"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":2,"Region":1,"Coiled coil":1,"Compositional bias":1,"Disulfide bond":2},"uniParcId":"UPI0040314B3B"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8RA68","uniProtkbId":"A0ACI8RA68_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000575003.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00016534"}],"value":"Fibrinogen beta chain"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000575003.1"}],"value":"FGB"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00025974"}],"value":"Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004613"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00739"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":30,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":31,"modifier":"EXACT"},"end":{"value":449,"modifier":"EXACT"}},"description":"Fibrinogen beta chain","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5051421202"},{"type":"Domain","location":{"start":{"value":232,"modifier":"EXACT"},"end":{"value":277,"modifier":"EXACT"}},"description":"Fibrinogen C-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51406"}]},{"type":"Domain","location":{"start":{"value":278,"modifier":"EXACT"},"end":{"value":446,"modifier":"EXACT"}},"description":"Fibrinogen C-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51406"}]},{"type":"Region","location":{"start":{"value":44,"modifier":"EXACT"},"end":{"value":75,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":195,"modifier":"EXACT"},"end":{"value":222,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Compositional bias","location":{"start":{"value":47,"modifier":"EXACT"},"end":{"value":57,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Disulfide bond","location":{"start":{"value":241,"modifier":"EXACT"},"end":{"value":270,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00739"}]},{"type":"Disulfide bond","location":{"start":{"value":382,"modifier":"EXACT"},"end":{"value":395,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00739"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023084"}],"id":"KW-0094","category":"Biological process","name":"Blood coagulation"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023054"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00739"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022696"}],"id":"KW-0356","category":"Biological process","name":"Hemostasis"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8RA68"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8RA68"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000575003.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000575003.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15815621","citationType":"journal article","authors":["Hillier L.W.","Graves T.A.","Fulton R.S.","Fulton L.A.","Pepin K.H.","Minx P.","Wagner-McPherson C.","Layman D.","Wylie K.","Sekhon M.","Becker M.C.","Fewell G.A.","Delehaunty K.D.","Miner T.L.","Nash W.E.","Kremitzki C.","Oddy L.","Du H.","Sun H.","Bradshaw-Cordum H.","Ali J.","Carter J.","Cordes M.","Harris A.","Isak A.","van Brunt A.","Nguyen C.","Du F.","Courtney L.","Kalicki J.","Ozersky P.","Abbott S.","Armstrong J.","Belter E.A.","Caruso L.","Cedroni M.","Cotton M.","Davidson T.","Desai A.","Elliott G.","Erb T.","Fronick C.","Gaige T.","Haakenson W.","Haglund K.","Holmes A.","Harkins R.","Kim K.","Kruchowski S.S.","Strong C.M.","Grewal N.","Goyea E.","Hou S.","Levy A.","Martinka S.","Mead K.","McLellan M.D.","Meyer R.","Randall-Maher J.","Tomlinson C.","Dauphin-Kohlberg S.","Kozlowicz-Reilly A.","Shah N.","Swearengen-Shahid S.","Snider J.","Strong J.T.","Thompson J.","Yoakum M.","Leonard S.","Pearman C.","Trani L.","Radionenko M.","Waligorski J.E.","Wang C.","Rock S.M.","Tin-Wollam A.M.","Maupin R.","Latreille P.","Wendl M.C.","Yang S.P.","Pohl C.","Wallis J.W.","Spieth J.","Bieri T.A.","Berkowicz N.","Nelson J.O.","Osborne J.","Ding L.","Meyer R.","Sabo A.","Shotland Y.","Sinha P.","Wohldmann P.E.","Cook L.L.","Hickenbotham M.T.","Eldred J.","Williams D.","Jones T.A.","She X.","Ciccarelli F.D.","Izaurralde E.","Taylor J.","Schmutz J.","Myers R.M.","Cox D.R.","Huang X.","McPherson J.D.","Mardis E.R.","Clifton S.W.","Warren W.C.","Chinwalla A.T.","Eddy S.R.","Marra M.A.","Ovcharenko I.","Furey T.S.","Miller W.","Eichler E.E.","Bork P.","Suyama M.","Torrents D.","Waterston R.H.","Wilson R.K."],"citationCrossReferences":[{"database":"PubMed","id":"15815621"},{"database":"DOI","id":"10.1038/nature03466"}],"title":"Generation and annotation of the DNA sequences of human chromosomes 2 and 4.","publicationDate":"2005","journal":"Nature","firstPage":"724","lastPage":"731","volume":"434"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000575003.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000575003.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC107385","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000904944.1","properties":[{"key":"ProteinId","value":"ENSP00000575003.1"},{"key":"GeneId","value":"ENSG00000171564.13"}]},{"database":"HGNC","id":"HGNC:3662","properties":[{"key":"GeneName","value":"FGB"}]},{"database":"OpenTargets","id":"ENSG00000171564","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000158122","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 4"}]},{"database":"CDD","id":"cd00087","properties":[{"key":"EntryName","value":"FReD"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.5.50:FF:000004","properties":[{"key":"EntryName","value":"Fibrinogen beta chain"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"4.10.530.10:FF:000004","properties":[{"key":"EntryName","value":"Fibrinogen beta chain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.5.50","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"3.90.215.10","properties":[{"key":"EntryName","value":"Gamma Fibrinogen, chain A, domain 1"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"4.10.530.10","properties":[{"key":"EntryName","value":"Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR037579","properties":[{"key":"EntryName","value":"FIB_ANG-like"}]},{"database":"InterPro","id":"IPR036056","properties":[{"key":"EntryName","value":"Fibrinogen-like_C"}]},{"database":"InterPro","id":"IPR014716","properties":[{"key":"EntryName","value":"Fibrinogen_a/b/g_C_1"}]},{"database":"InterPro","id":"IPR002181","properties":[{"key":"EntryName","value":"Fibrinogen_a/b/g_C_dom"}]},{"database":"InterPro","id":"IPR012290","properties":[{"key":"EntryName","value":"Fibrinogen_a/b/g_coil_dom"}]},{"database":"InterPro","id":"IPR020837","properties":[{"key":"EntryName","value":"Fibrinogen_CS"}]},{"database":"NCBIfam","id":"NF040941","properties":[{"key":"EntryName","value":"GGGWT_bact"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR47221","properties":[{"key":"EntryName","value":"FIBRINOGEN ALPHA CHAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR47221:SF5","properties":[{"key":"EntryName","value":"FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08702","properties":[{"key":"EntryName","value":"Fib_alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00147","properties":[{"key":"EntryName","value":"Fibrinogen_C"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00186","properties":[{"key":"EntryName","value":"FBG"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM01212","properties":[{"key":"EntryName","value":"Fib_alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56496","properties":[{"key":"EntryName","value":"Fibrinogen C-terminal domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF58010","properties":[{"key":"EntryName","value":"Fibrinogen coiled-coil and central regions"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00514","properties":[{"key":"EntryName","value":"FIBRINOGEN_C_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51406","properties":[{"key":"EntryName","value":"FIBRINOGEN_C_2"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MKRMVSWSFHKLKTMKHLLLLLLCVFLVKSQGVNDNEEGFFSARGHRPLDKKREEAPSLRPAPPPISGGGYRARPAKAAATQKKVERKAPDAGGCLHADPDLGVLCPTGCQLQEALLQQERPIRNSVDELNNNVEAVSQTSSSSFQYMYLLKDLWQKRQKQVKDNENVVNEYSSELEKHQLYIDETVNSNIPTNLRVLRSILENLRSKIQKLESDVSAQMEYCRTPCTVSCNIPVVSGKECEEIIRKGGETSEMYLIQPDSSVKPYRVYCDMNTENGGEYWLGNDKISQLTRMGPTELLIEMEDWKGDKVKAHYGGFTVQNEANKYQISVNKYRGTAGNALMDGASQLMGENRTMTIHNGMFFSTYDRDNDGWLTSDPRKQCSKEDGGGWWYNRCHAANPNGRYYWGGQYTWDMAKHGTDDGVVWMNWKGSWYSMRKMSMKIRPFFPQQ","length":449,"molWeight":51255,"crc64":"4331D67DB99F0C2E","md5":"938B87F0DE452BFD3C6A835D7D9384A3"},"extraAttributes":{"countByCommentType":{"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":2,"Region":1,"Coiled coil":1,"Compositional bias":1,"Disulfide bond":2},"uniParcId":"UPI0040322E24"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8SGZ4","uniProtkbId":"A0ACI8SGZ4_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000575006.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000575006.1"}],"value":"Fibrinogen beta chain"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000575006.1"}],"value":"FGB"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00025974"}],"value":"Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004613"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00739"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":30,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":31,"modifier":"EXACT"},"end":{"value":390,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5051386075"},{"type":"Domain","location":{"start":{"value":247,"modifier":"EXACT"},"end":{"value":387,"modifier":"EXACT"}},"description":"Fibrinogen C-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51406"}]},{"type":"Region","location":{"start":{"value":44,"modifier":"EXACT"},"end":{"value":75,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":195,"modifier":"EXACT"},"end":{"value":222,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Compositional bias","location":{"start":{"value":47,"modifier":"EXACT"},"end":{"value":57,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Disulfide bond","location":{"start":{"value":323,"modifier":"EXACT"},"end":{"value":336,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00739"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023084"}],"id":"KW-0094","category":"Biological process","name":"Blood coagulation"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023054"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00739"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022696"}],"id":"KW-0356","category":"Biological process","name":"Hemostasis"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8SGZ4"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8SGZ4"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000575006.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000575006.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15815621","citationType":"journal article","authors":["Hillier L.W.","Graves T.A.","Fulton R.S.","Fulton L.A.","Pepin K.H.","Minx P.","Wagner-McPherson C.","Layman D.","Wylie K.","Sekhon M.","Becker M.C.","Fewell G.A.","Delehaunty K.D.","Miner T.L.","Nash W.E.","Kremitzki C.","Oddy L.","Du H.","Sun H.","Bradshaw-Cordum H.","Ali J.","Carter J.","Cordes M.","Harris A.","Isak A.","van Brunt A.","Nguyen C.","Du F.","Courtney L.","Kalicki J.","Ozersky P.","Abbott S.","Armstrong J.","Belter E.A.","Caruso L.","Cedroni M.","Cotton M.","Davidson T.","Desai A.","Elliott G.","Erb T.","Fronick C.","Gaige T.","Haakenson W.","Haglund K.","Holmes A.","Harkins R.","Kim K.","Kruchowski S.S.","Strong C.M.","Grewal N.","Goyea E.","Hou S.","Levy A.","Martinka S.","Mead K.","McLellan M.D.","Meyer R.","Randall-Maher J.","Tomlinson C.","Dauphin-Kohlberg S.","Kozlowicz-Reilly A.","Shah N.","Swearengen-Shahid S.","Snider J.","Strong J.T.","Thompson J.","Yoakum M.","Leonard S.","Pearman C.","Trani L.","Radionenko M.","Waligorski J.E.","Wang C.","Rock S.M.","Tin-Wollam A.M.","Maupin R.","Latreille P.","Wendl M.C.","Yang S.P.","Pohl C.","Wallis J.W.","Spieth J.","Bieri T.A.","Berkowicz N.","Nelson J.O.","Osborne J.","Ding L.","Meyer R.","Sabo A.","Shotland Y.","Sinha P.","Wohldmann P.E.","Cook L.L.","Hickenbotham M.T.","Eldred J.","Williams D.","Jones T.A.","She X.","Ciccarelli F.D.","Izaurralde E.","Taylor J.","Schmutz J.","Myers R.M.","Cox D.R.","Huang X.","McPherson J.D.","Mardis E.R.","Clifton S.W.","Warren W.C.","Chinwalla A.T.","Eddy S.R.","Marra M.A.","Ovcharenko I.","Furey T.S.","Miller W.","Eichler E.E.","Bork P.","Suyama M.","Torrents D.","Waterston R.H.","Wilson R.K."],"citationCrossReferences":[{"database":"PubMed","id":"15815621"},{"database":"DOI","id":"10.1038/nature03466"}],"title":"Generation and annotation of the DNA sequences of human chromosomes 2 and 4.","publicationDate":"2005","journal":"Nature","firstPage":"724","lastPage":"731","volume":"434"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000575006.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000575006.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC107385","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000904947.1","properties":[{"key":"ProteinId","value":"ENSP00000575006.1"},{"key":"GeneId","value":"ENSG00000171564.13"}]},{"database":"HGNC","id":"HGNC:3662","properties":[{"key":"GeneName","value":"FGB"}]},{"database":"OpenTargets","id":"ENSG00000171564","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000158122","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 4"}]},{"database":"FunFam","id":"1.20.5.50:FF:000004","properties":[{"key":"EntryName","value":"Fibrinogen beta chain"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"4.10.530.10:FF:000004","properties":[{"key":"EntryName","value":"Fibrinogen beta chain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.5.50","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"3.90.215.10","properties":[{"key":"EntryName","value":"Gamma Fibrinogen, chain A, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR037579","properties":[{"key":"EntryName","value":"FIB_ANG-like"}]},{"database":"InterPro","id":"IPR036056","properties":[{"key":"EntryName","value":"Fibrinogen-like_C"}]},{"database":"InterPro","id":"IPR014716","properties":[{"key":"EntryName","value":"Fibrinogen_a/b/g_C_1"}]},{"database":"InterPro","id":"IPR002181","properties":[{"key":"EntryName","value":"Fibrinogen_a/b/g_C_dom"}]},{"database":"InterPro","id":"IPR012290","properties":[{"key":"EntryName","value":"Fibrinogen_a/b/g_coil_dom"}]},{"database":"InterPro","id":"IPR020837","properties":[{"key":"EntryName","value":"Fibrinogen_CS"}]},{"database":"PANTHER","id":"PTHR47221","properties":[{"key":"EntryName","value":"FIBRINOGEN ALPHA CHAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR47221:SF6","properties":[{"key":"EntryName","value":"FIBRINOGEN ALPHA CHAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08702","properties":[{"key":"EntryName","value":"Fib_alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00147","properties":[{"key":"EntryName","value":"Fibrinogen_C"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00186","properties":[{"key":"EntryName","value":"FBG"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM01212","properties":[{"key":"EntryName","value":"Fib_alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56496","properties":[{"key":"EntryName","value":"Fibrinogen C-terminal domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF58010","properties":[{"key":"EntryName","value":"Fibrinogen coiled-coil and central regions"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00514","properties":[{"key":"EntryName","value":"FIBRINOGEN_C_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51406","properties":[{"key":"EntryName","value":"FIBRINOGEN_C_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MKRMVSWSFHKLKTMKHLLLLLLCVFLVKSQGVNDNEEGFFSARGHRPLDKKREEAPSLRPAPPPISGGGYRARPAKAAATQKKVERKAPDAGGCLHADPDLGVLCPTGCQLQEALLQQERPIRNSVDELNNNVEAVSQTSSSSFQYMYLLKDLWQKRQKQVKDNENVVNEYSSELEKHQLYIDETVNSNIPTNLRVLRSILENLRSKIQKLESDVSAQMEYCRTPCTVSCNIPVVSGKECEEIIRKGDKVKAHYGGFTVQNEANKYQISVNKYRGTAGNALMDGASQLMGENRTMTIHNGMFFSTYDRDNDGWLTSDPRKQCSKEDGGGWWYNRCHAANPNGRYYWGGQYTWDMAKHGTDDGVVWMNWKGSWYSMRKMSMKIRPFFPQQ","length":390,"molWeight":44452,"crc64":"7E360DAEFC461519","md5":"14ABECEA69AC6CF84BC7821E2E9CE96A"},"extraAttributes":{"countByCommentType":{"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":1,"Region":1,"Coiled coil":1,"Compositional bias":1,"Disulfide bond":1},"uniParcId":"UPI004031DA95"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8RVZ9","uniProtkbId":"A0ACI8RVZ9_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000575004.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00016534"}],"value":"Fibrinogen beta chain"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000575004.1"}],"value":"FGB"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00025974"}],"value":"Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004613"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00739"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":30,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":31,"modifier":"EXACT"},"end":{"value":377,"modifier":"EXACT"}},"description":"Fibrinogen beta chain","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5051276934"},{"type":"Domain","location":{"start":{"value":117,"modifier":"EXACT"},"end":{"value":374,"modifier":"EXACT"}},"description":"Fibrinogen C-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51406"}]},{"type":"Region","location":{"start":{"value":44,"modifier":"EXACT"},"end":{"value":74,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":47,"modifier":"EXACT"},"end":{"value":57,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Disulfide bond","location":{"start":{"value":310,"modifier":"EXACT"},"end":{"value":323,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00739"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023084"}],"id":"KW-0094","category":"Biological process","name":"Blood coagulation"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023054"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00739"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022696"}],"id":"KW-0356","category":"Biological process","name":"Hemostasis"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8RVZ9"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8RVZ9"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000575004.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000575004.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15815621","citationType":"journal article","authors":["Hillier L.W.","Graves T.A.","Fulton R.S.","Fulton L.A.","Pepin K.H.","Minx P.","Wagner-McPherson C.","Layman D.","Wylie K.","Sekhon M.","Becker M.C.","Fewell G.A.","Delehaunty K.D.","Miner T.L.","Nash W.E.","Kremitzki C.","Oddy L.","Du H.","Sun H.","Bradshaw-Cordum H.","Ali J.","Carter J.","Cordes M.","Harris A.","Isak A.","van Brunt A.","Nguyen C.","Du F.","Courtney L.","Kalicki J.","Ozersky P.","Abbott S.","Armstrong J.","Belter E.A.","Caruso L.","Cedroni M.","Cotton M.","Davidson T.","Desai A.","Elliott G.","Erb T.","Fronick C.","Gaige T.","Haakenson W.","Haglund K.","Holmes A.","Harkins R.","Kim K.","Kruchowski S.S.","Strong C.M.","Grewal N.","Goyea E.","Hou S.","Levy A.","Martinka S.","Mead K.","McLellan M.D.","Meyer R.","Randall-Maher J.","Tomlinson C.","Dauphin-Kohlberg S.","Kozlowicz-Reilly A.","Shah N.","Swearengen-Shahid S.","Snider J.","Strong J.T.","Thompson J.","Yoakum M.","Leonard S.","Pearman C.","Trani L.","Radionenko M.","Waligorski J.E.","Wang C.","Rock S.M.","Tin-Wollam A.M.","Maupin R.","Latreille P.","Wendl M.C.","Yang S.P.","Pohl C.","Wallis J.W.","Spieth J.","Bieri T.A.","Berkowicz N.","Nelson J.O.","Osborne J.","Ding L.","Meyer R.","Sabo A.","Shotland Y.","Sinha P.","Wohldmann P.E.","Cook L.L.","Hickenbotham M.T.","Eldred J.","Williams D.","Jones T.A.","She X.","Ciccarelli F.D.","Izaurralde E.","Taylor J.","Schmutz J.","Myers R.M.","Cox D.R.","Huang X.","McPherson J.D.","Mardis E.R.","Clifton S.W.","Warren W.C.","Chinwalla A.T.","Eddy S.R.","Marra M.A.","Ovcharenko I.","Furey T.S.","Miller W.","Eichler E.E.","Bork P.","Suyama M.","Torrents D.","Waterston R.H.","Wilson R.K."],"citationCrossReferences":[{"database":"PubMed","id":"15815621"},{"database":"DOI","id":"10.1038/nature03466"}],"title":"Generation and annotation of the DNA sequences of human chromosomes 2 and 4.","publicationDate":"2005","journal":"Nature","firstPage":"724","lastPage":"731","volume":"434"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000575004.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000575004.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC107385","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000904945.1","properties":[{"key":"ProteinId","value":"ENSP00000575004.1"},{"key":"GeneId","value":"ENSG00000171564.13"}]},{"database":"HGNC","id":"HGNC:3662","properties":[{"key":"GeneName","value":"FGB"}]},{"database":"OpenTargets","id":"ENSG00000171564","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000158122","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 4"}]},{"database":"CDD","id":"cd00087","properties":[{"key":"EntryName","value":"FReD"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.5.50:FF:000004","properties":[{"key":"EntryName","value":"Fibrinogen beta chain"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"4.10.530.10:FF:000004","properties":[{"key":"EntryName","value":"Fibrinogen beta chain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.5.50","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.90.215.10","properties":[{"key":"EntryName","value":"Gamma Fibrinogen, chain A, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR037579","properties":[{"key":"EntryName","value":"FIB_ANG-like"}]},{"database":"InterPro","id":"IPR036056","properties":[{"key":"EntryName","value":"Fibrinogen-like_C"}]},{"database":"InterPro","id":"IPR014716","properties":[{"key":"EntryName","value":"Fibrinogen_a/b/g_C_1"}]},{"database":"InterPro","id":"IPR002181","properties":[{"key":"EntryName","value":"Fibrinogen_a/b/g_C_dom"}]},{"database":"InterPro","id":"IPR012290","properties":[{"key":"EntryName","value":"Fibrinogen_a/b/g_coil_dom"}]},{"database":"InterPro","id":"IPR020837","properties":[{"key":"EntryName","value":"Fibrinogen_CS"}]},{"database":"PANTHER","id":"PTHR47221","properties":[{"key":"EntryName","value":"FIBRINOGEN ALPHA CHAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR47221:SF5","properties":[{"key":"EntryName","value":"FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00147","properties":[{"key":"EntryName","value":"Fibrinogen_C"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00186","properties":[{"key":"EntryName","value":"FBG"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM01212","properties":[{"key":"EntryName","value":"Fib_alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56496","properties":[{"key":"EntryName","value":"Fibrinogen C-terminal domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF58010","properties":[{"key":"EntryName","value":"Fibrinogen coiled-coil and central regions"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00514","properties":[{"key":"EntryName","value":"FIBRINOGEN_C_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51406","properties":[{"key":"EntryName","value":"FIBRINOGEN_C_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MKRMVSWSFHKLKTMKHLLLLLLCVFLVKSQGVNDNEEGFFSARGHRPLDKKREEAPSLRPAPPPISGGGYRARPAKAAATQKKVERKAPDAGGCLHADPDLGVLCPTGCQLQEALLQQERPIRNSVDELNNNVEAVSQTSSSSFQYMYLLKDLWQKRQKQVKGWTVIQNRQDGSVDFGRKWDPYKQGFGNVATNTDGKNYCGLPGEYWLGNDKISQLTRMGPTELLIEMEDWKGDKVKAHYGGFTVQNEANKYQISVNKYRGTAGNALMDGASQLMGENRTMTIHNGMFFSTYDRDNDGWLTSDPRKQCSKEDGGGWWYNRCHAANPNGRYYWGGQYTWDMAKHGTDDGVVWMNWKGSWYSMRKMSMKIRPFFPQQ","length":377,"molWeight":42922,"crc64":"238EC183824A8272","md5":"302C9ED1AE20CB5431B630D9DD040F7F"},"extraAttributes":{"countByCommentType":{"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":1,"Region":1,"Compositional bias":1,"Disulfide bond":1},"uniParcId":"UPI004032390A"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8RFX0","uniProtkbId":"A0ACI8RFX0_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000574998.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00016534"}],"value":"Fibrinogen beta chain"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000574998.1"}],"value":"FGB"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00055482"}],"value":"Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00025974"}],"value":"Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004613"}],"value":"Secreted","id":"SL-0243"}}]}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":30,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":31,"modifier":"EXACT"},"end":{"value":415,"modifier":"EXACT"}},"description":"Fibrinogen beta chain","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5051530651"},{"type":"Domain","location":{"start":{"value":156,"modifier":"EXACT"},"end":{"value":412,"modifier":"EXACT"}},"description":"Fibrinogen C-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51406"}]},{"type":"Region","location":{"start":{"value":44,"modifier":"EXACT"},"end":{"value":75,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":47,"modifier":"EXACT"},"end":{"value":57,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Disulfide bond","location":{"start":{"value":165,"modifier":"EXACT"},"end":{"value":194,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00739"}]},{"type":"Disulfide bond","location":{"start":{"value":348,"modifier":"EXACT"},"end":{"value":361,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00739"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023130"}],"id":"KW-1064","category":"Biological process","name":"Adaptive immunity"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023084"}],"id":"KW-0094","category":"Biological process","name":"Blood coagulation"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023054"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00739"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022696"}],"id":"KW-0356","category":"Biological process","name":"Hemostasis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022859"}],"id":"KW-0391","category":"Biological process","name":"Immunity"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022588"}],"id":"KW-0399","category":"Biological process","name":"Innate immunity"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8RFX0"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8RFX0"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000574998.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000574998.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15815621","citationType":"journal article","authors":["Hillier L.W.","Graves T.A.","Fulton R.S.","Fulton L.A.","Pepin K.H.","Minx P.","Wagner-McPherson C.","Layman D.","Wylie K.","Sekhon M.","Becker M.C.","Fewell G.A.","Delehaunty K.D.","Miner T.L.","Nash W.E.","Kremitzki C.","Oddy L.","Du H.","Sun H.","Bradshaw-Cordum H.","Ali J.","Carter J.","Cordes M.","Harris A.","Isak A.","van Brunt A.","Nguyen C.","Du F.","Courtney L.","Kalicki J.","Ozersky P.","Abbott S.","Armstrong J.","Belter E.A.","Caruso L.","Cedroni M.","Cotton M.","Davidson T.","Desai A.","Elliott G.","Erb T.","Fronick C.","Gaige T.","Haakenson W.","Haglund K.","Holmes A.","Harkins R.","Kim K.","Kruchowski S.S.","Strong C.M.","Grewal N.","Goyea E.","Hou S.","Levy A.","Martinka S.","Mead K.","McLellan M.D.","Meyer R.","Randall-Maher J.","Tomlinson C.","Dauphin-Kohlberg S.","Kozlowicz-Reilly A.","Shah N.","Swearengen-Shahid S.","Snider J.","Strong J.T.","Thompson J.","Yoakum M.","Leonard S.","Pearman C.","Trani L.","Radionenko M.","Waligorski J.E.","Wang C.","Rock S.M.","Tin-Wollam A.M.","Maupin R.","Latreille P.","Wendl M.C.","Yang S.P.","Pohl C.","Wallis J.W.","Spieth J.","Bieri T.A.","Berkowicz N.","Nelson J.O.","Osborne J.","Ding L.","Meyer R.","Sabo A.","Shotland Y.","Sinha P.","Wohldmann P.E.","Cook L.L.","Hickenbotham M.T.","Eldred J.","Williams D.","Jones T.A.","She X.","Ciccarelli F.D.","Izaurralde E.","Taylor J.","Schmutz J.","Myers R.M.","Cox D.R.","Huang X.","McPherson J.D.","Mardis E.R.","Clifton S.W.","Warren W.C.","Chinwalla A.T.","Eddy S.R.","Marra M.A.","Ovcharenko I.","Furey T.S.","Miller W.","Eichler E.E.","Bork P.","Suyama M.","Torrents D.","Waterston R.H.","Wilson R.K."],"citationCrossReferences":[{"database":"PubMed","id":"15815621"},{"database":"DOI","id":"10.1038/nature03466"}],"title":"Generation and annotation of the DNA sequences of human chromosomes 2 and 4.","publicationDate":"2005","journal":"Nature","firstPage":"724","lastPage":"731","volume":"434"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000574998.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000574998.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC107385","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000904939.1","properties":[{"key":"ProteinId","value":"ENSP00000574998.1"},{"key":"GeneId","value":"ENSG00000171564.13"}]},{"database":"HGNC","id":"HGNC:3662","properties":[{"key":"GeneName","value":"FGB"}]},{"database":"OpenTargets","id":"ENSG00000171564","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000158122","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 4"}]},{"database":"CDD","id":"cd00087","properties":[{"key":"EntryName","value":"FReD"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.5.50:FF:000004","properties":[{"key":"EntryName","value":"Fibrinogen beta chain"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.215.10:FF:000006","properties":[{"key":"EntryName","value":"Fibrinogen beta chain"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"4.10.530.10:FF:000004","properties":[{"key":"EntryName","value":"Fibrinogen beta chain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.5.50","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.90.215.10","properties":[{"key":"EntryName","value":"Gamma Fibrinogen, chain A, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR037579","properties":[{"key":"EntryName","value":"FIB_ANG-like"}]},{"database":"InterPro","id":"IPR036056","properties":[{"key":"EntryName","value":"Fibrinogen-like_C"}]},{"database":"InterPro","id":"IPR014716","properties":[{"key":"EntryName","value":"Fibrinogen_a/b/g_C_1"}]},{"database":"InterPro","id":"IPR002181","properties":[{"key":"EntryName","value":"Fibrinogen_a/b/g_C_dom"}]},{"database":"InterPro","id":"IPR012290","properties":[{"key":"EntryName","value":"Fibrinogen_a/b/g_coil_dom"}]},{"database":"InterPro","id":"IPR020837","properties":[{"key":"EntryName","value":"Fibrinogen_CS"}]},{"database":"NCBIfam","id":"NF040941","properties":[{"key":"EntryName","value":"GGGWT_bact"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR47221","properties":[{"key":"EntryName","value":"FIBRINOGEN ALPHA CHAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR47221:SF5","properties":[{"key":"EntryName","value":"FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00147","properties":[{"key":"EntryName","value":"Fibrinogen_C"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00186","properties":[{"key":"EntryName","value":"FBG"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM01212","properties":[{"key":"EntryName","value":"Fib_alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56496","properties":[{"key":"EntryName","value":"Fibrinogen C-terminal domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF58010","properties":[{"key":"EntryName","value":"Fibrinogen coiled-coil and central regions"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00514","properties":[{"key":"EntryName","value":"FIBRINOGEN_C_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51406","properties":[{"key":"EntryName","value":"FIBRINOGEN_C_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MKRMVSWSFHKLKTMKHLLLLLLCVFLVKSQGVNDNEEGFFSARGHRPLDKKREEAPSLRPAPPPISGGGYRARPAKAAATQKKVERKAPDAGGCLHADPDLGVLCPTGCQLQEALLQQERPIRNSVDELNNNVEAVSQTSSSSFQYMYLLKDLWQKRQKQVKECEEIIRKGGETSEMYLIQPDSSVKPYRVYCDMNTENGGWTVIQNRQDGSVDFGRKWDPYKQGFGNVATNTDGKNYCGLPGEYWLGNDKISQLTRMGPTELLIEMEDWKGDKVKAHYGGFTVQNEANKYQISVNKYRGTAGNALMDGASQLMGENRTMTIHNGMFFSTYDRDNDGWLTSDPRKQCSKEDGGGWWYNRCHAANPNGRYYWGGQYTWDMAKHGTDDGVVWMNWKGSWYSMRKMSMKIRPFFPQQ","length":415,"molWeight":47289,"crc64":"1E57AB8A4A72FF91","md5":"89BFD768F86AFC2DF939E3B414377740"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":1,"Region":1,"Compositional bias":1,"Disulfide bond":2},"uniParcId":"UPI004031939A"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8RJE9","uniProtkbId":"A0ACI8RJE9_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000574999.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00016534"}],"value":"Fibrinogen beta chain"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000574999.1"}],"value":"FGB"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00025974"}],"value":"Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004613"}],"value":"Secreted","id":"SL-0243"}}]}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":30,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":31,"modifier":"EXACT"},"end":{"value":483,"modifier":"EXACT"}},"description":"Fibrinogen beta chain","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5051426854"},{"type":"Domain","location":{"start":{"value":232,"modifier":"EXACT"},"end":{"value":480,"modifier":"EXACT"}},"description":"Fibrinogen C-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51406"}]},{"type":"Region","location":{"start":{"value":44,"modifier":"EXACT"},"end":{"value":74,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":195,"modifier":"EXACT"},"end":{"value":222,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Compositional bias","location":{"start":{"value":47,"modifier":"EXACT"},"end":{"value":57,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Disulfide bond","location":{"start":{"value":241,"modifier":"EXACT"},"end":{"value":270,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00739"}]},{"type":"Disulfide bond","location":{"start":{"value":416,"modifier":"EXACT"},"end":{"value":429,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00739"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023130"}],"id":"KW-1064","category":"Biological process","name":"Adaptive immunity"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023084"}],"id":"KW-0094","category":"Biological process","name":"Blood coagulation"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023054"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00739"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022696"}],"id":"KW-0356","category":"Biological process","name":"Hemostasis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022859"}],"id":"KW-0391","category":"Biological process","name":"Immunity"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022588"}],"id":"KW-0399","category":"Biological process","name":"Innate immunity"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8RJE9"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8RJE9"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000574999.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000574999.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15815621","citationType":"journal article","authors":["Hillier L.W.","Graves T.A.","Fulton R.S.","Fulton L.A.","Pepin K.H.","Minx P.","Wagner-McPherson C.","Layman D.","Wylie K.","Sekhon M.","Becker M.C.","Fewell G.A.","Delehaunty K.D.","Miner T.L.","Nash W.E.","Kremitzki C.","Oddy L.","Du H.","Sun H.","Bradshaw-Cordum H.","Ali J.","Carter J.","Cordes M.","Harris A.","Isak A.","van Brunt A.","Nguyen C.","Du F.","Courtney L.","Kalicki J.","Ozersky P.","Abbott S.","Armstrong J.","Belter E.A.","Caruso L.","Cedroni M.","Cotton M.","Davidson T.","Desai A.","Elliott G.","Erb T.","Fronick C.","Gaige T.","Haakenson W.","Haglund K.","Holmes A.","Harkins R.","Kim K.","Kruchowski S.S.","Strong C.M.","Grewal N.","Goyea E.","Hou S.","Levy A.","Martinka S.","Mead K.","McLellan M.D.","Meyer R.","Randall-Maher J.","Tomlinson C.","Dauphin-Kohlberg S.","Kozlowicz-Reilly A.","Shah N.","Swearengen-Shahid S.","Snider J.","Strong J.T.","Thompson J.","Yoakum M.","Leonard S.","Pearman C.","Trani L.","Radionenko M.","Waligorski J.E.","Wang C.","Rock S.M.","Tin-Wollam A.M.","Maupin R.","Latreille P.","Wendl M.C.","Yang S.P.","Pohl C.","Wallis J.W.","Spieth J.","Bieri T.A.","Berkowicz N.","Nelson J.O.","Osborne J.","Ding L.","Meyer R.","Sabo A.","Shotland Y.","Sinha P.","Wohldmann P.E.","Cook L.L.","Hickenbotham M.T.","Eldred J.","Williams D.","Jones T.A.","She X.","Ciccarelli F.D.","Izaurralde E.","Taylor J.","Schmutz J.","Myers R.M.","Cox D.R.","Huang X.","McPherson J.D.","Mardis E.R.","Clifton S.W.","Warren W.C.","Chinwalla A.T.","Eddy S.R.","Marra M.A.","Ovcharenko I.","Furey T.S.","Miller W.","Eichler E.E.","Bork P.","Suyama M.","Torrents D.","Waterston R.H.","Wilson R.K."],"citationCrossReferences":[{"database":"PubMed","id":"15815621"},{"database":"DOI","id":"10.1038/nature03466"}],"title":"Generation and annotation of the DNA sequences of human chromosomes 2 and 4.","publicationDate":"2005","journal":"Nature","firstPage":"724","lastPage":"731","volume":"434"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000574999.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000574999.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC107385","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"NP_001369694.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001382765.1"}]},{"database":"Ensembl","id":"ENST00000904940.1","properties":[{"key":"ProteinId","value":"ENSP00000574999.1"},{"key":"GeneId","value":"ENSG00000171564.13"}]},{"database":"GeneID","id":"2244","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:3662","properties":[{"key":"GeneName","value":"FGB"}]},{"database":"OpenTargets","id":"ENSG00000171564","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000158122","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 4"}]},{"database":"CDD","id":"cd00087","properties":[{"key":"EntryName","value":"FReD"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.5.50:FF:000004","properties":[{"key":"EntryName","value":"Fibrinogen beta chain"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.215.10:FF:000006","properties":[{"key":"EntryName","value":"Fibrinogen beta chain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.5.50","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"3.90.215.10","properties":[{"key":"EntryName","value":"Gamma Fibrinogen, chain A, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR037579","properties":[{"key":"EntryName","value":"FIB_ANG-like"}]},{"database":"InterPro","id":"IPR036056","properties":[{"key":"EntryName","value":"Fibrinogen-like_C"}]},{"database":"InterPro","id":"IPR014716","properties":[{"key":"EntryName","value":"Fibrinogen_a/b/g_C_1"}]},{"database":"InterPro","id":"IPR002181","properties":[{"key":"EntryName","value":"Fibrinogen_a/b/g_C_dom"}]},{"database":"InterPro","id":"IPR012290","properties":[{"key":"EntryName","value":"Fibrinogen_a/b/g_coil_dom"}]},{"database":"InterPro","id":"IPR020837","properties":[{"key":"EntryName","value":"Fibrinogen_CS"}]},{"database":"NCBIfam","id":"NF040941","properties":[{"key":"EntryName","value":"GGGWT_bact"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR47221","properties":[{"key":"EntryName","value":"FIBRINOGEN ALPHA CHAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR47221:SF5","properties":[{"key":"EntryName","value":"FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08702","properties":[{"key":"EntryName","value":"Fib_alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00147","properties":[{"key":"EntryName","value":"Fibrinogen_C"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00186","properties":[{"key":"EntryName","value":"FBG"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM01212","properties":[{"key":"EntryName","value":"Fib_alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56496","properties":[{"key":"EntryName","value":"Fibrinogen C-terminal domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF58010","properties":[{"key":"EntryName","value":"Fibrinogen coiled-coil and central regions"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00514","properties":[{"key":"EntryName","value":"FIBRINOGEN_C_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51406","properties":[{"key":"EntryName","value":"FIBRINOGEN_C_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MKRMVSWSFHKLKTMKHLLLLLLCVFLVKSQGVNDNEEGFFSARGHRPLDKKREEAPSLRPAPPPISGGGYRARPAKAAATQKKVERKAPDAGGCLHADPDLGVLCPTGCQLQEALLQQERPIRNSVDELNNNVEAVSQTSSSSFQYMYLLKDLWQKRQKQVKDNENVVNEYSSELEKHQLYIDETVNSNIPTNLRVLRSILENLRSKIQKLESDVSAQMEYCRTPCTVSCNIPVVSGKECEEIIRKGGETSEMYLIQPDSSVKPYRVYCDMNTENGGWTVIQNRQDGSVDFGRKWDPYKQGFGNVATNTDGKNYCGLPGEYWLGNDKISQLTRMGPTELLIEMEDWKGDKVKAHYGGFTVQNEANKYQISVNKYRGTAGNALMDGASQLMGENRTMTIHNGMFFSTLTSDPRKQCSKEDGGGWWYNRCHAANPNGRYYWGGQYTWDMAKHGTDDGVVWMNWKGSWYSMRKMSMKIRPFFPQQ","length":483,"molWeight":54906,"crc64":"D2240123231D4738","md5":"E958B0FE4E9401138F726921D7C40424"},"extraAttributes":{"countByCommentType":{"SUBUNIT":1,"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":1,"Region":1,"Coiled coil":1,"Compositional bias":1,"Disulfide bond":2},"uniParcId":"UPI00148E7639"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8S7E7","uniProtkbId":"A0ACI8S7E7_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000575002.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00016534"}],"value":"Fibrinogen beta chain"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000575002.1"}],"value":"FGB"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00025974"}],"value":"Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004613"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00739"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":30,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":31,"modifier":"EXACT"},"end":{"value":453,"modifier":"EXACT"}},"description":"Fibrinogen beta chain","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5051502488"},{"type":"Domain","location":{"start":{"value":186,"modifier":"EXACT"},"end":{"value":450,"modifier":"EXACT"}},"description":"Fibrinogen C-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51406"}]},{"type":"Region","location":{"start":{"value":44,"modifier":"EXACT"},"end":{"value":75,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":195,"modifier":"EXACT"},"end":{"value":222,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Compositional bias","location":{"start":{"value":47,"modifier":"EXACT"},"end":{"value":57,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Disulfide bond","location":{"start":{"value":386,"modifier":"EXACT"},"end":{"value":399,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00739"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023084"}],"id":"KW-0094","category":"Biological process","name":"Blood coagulation"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023054"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00739"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022696"}],"id":"KW-0356","category":"Biological process","name":"Hemostasis"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8S7E7"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8S7E7"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000575002.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000575002.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15815621","citationType":"journal article","authors":["Hillier L.W.","Graves T.A.","Fulton R.S.","Fulton L.A.","Pepin K.H.","Minx P.","Wagner-McPherson C.","Layman D.","Wylie K.","Sekhon M.","Becker M.C.","Fewell G.A.","Delehaunty K.D.","Miner T.L.","Nash W.E.","Kremitzki C.","Oddy L.","Du H.","Sun H.","Bradshaw-Cordum H.","Ali J.","Carter J.","Cordes M.","Harris A.","Isak A.","van Brunt A.","Nguyen C.","Du F.","Courtney L.","Kalicki J.","Ozersky P.","Abbott S.","Armstrong J.","Belter E.A.","Caruso L.","Cedroni M.","Cotton M.","Davidson T.","Desai A.","Elliott G.","Erb T.","Fronick C.","Gaige T.","Haakenson W.","Haglund K.","Holmes A.","Harkins R.","Kim K.","Kruchowski S.S.","Strong C.M.","Grewal N.","Goyea E.","Hou S.","Levy A.","Martinka S.","Mead K.","McLellan M.D.","Meyer R.","Randall-Maher J.","Tomlinson C.","Dauphin-Kohlberg S.","Kozlowicz-Reilly A.","Shah N.","Swearengen-Shahid S.","Snider J.","Strong J.T.","Thompson J.","Yoakum M.","Leonard S.","Pearman C.","Trani L.","Radionenko M.","Waligorski J.E.","Wang C.","Rock S.M.","Tin-Wollam A.M.","Maupin R.","Latreille P.","Wendl M.C.","Yang S.P.","Pohl C.","Wallis J.W.","Spieth J.","Bieri T.A.","Berkowicz N.","Nelson J.O.","Osborne J.","Ding L.","Meyer R.","Sabo A.","Shotland Y.","Sinha P.","Wohldmann P.E.","Cook L.L.","Hickenbotham M.T.","Eldred J.","Williams D.","Jones T.A.","She X.","Ciccarelli F.D.","Izaurralde E.","Taylor J.","Schmutz J.","Myers R.M.","Cox D.R.","Huang X.","McPherson J.D.","Mardis E.R.","Clifton S.W.","Warren W.C.","Chinwalla A.T.","Eddy S.R.","Marra M.A.","Ovcharenko I.","Furey T.S.","Miller W.","Eichler E.E.","Bork P.","Suyama M.","Torrents D.","Waterston R.H.","Wilson R.K."],"citationCrossReferences":[{"database":"PubMed","id":"15815621"},{"database":"DOI","id":"10.1038/nature03466"}],"title":"Generation and annotation of the DNA sequences of human chromosomes 2 and 4.","publicationDate":"2005","journal":"Nature","firstPage":"724","lastPage":"731","volume":"434"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000575002.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000575002.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC107385","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000904943.1","properties":[{"key":"ProteinId","value":"ENSP00000575002.1"},{"key":"GeneId","value":"ENSG00000171564.13"}]},{"database":"HGNC","id":"HGNC:3662","properties":[{"key":"GeneName","value":"FGB"}]},{"database":"OpenTargets","id":"ENSG00000171564","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000158122","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 4"}]},{"database":"CDD","id":"cd00087","properties":[{"key":"EntryName","value":"FReD"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.5.50:FF:000004","properties":[{"key":"EntryName","value":"Fibrinogen beta chain"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"4.10.530.10:FF:000004","properties":[{"key":"EntryName","value":"Fibrinogen beta chain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.5.50","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"3.90.215.10","properties":[{"key":"EntryName","value":"Gamma Fibrinogen, chain A, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"4.10.530.10","properties":[{"key":"EntryName","value":"Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR037579","properties":[{"key":"EntryName","value":"FIB_ANG-like"}]},{"database":"InterPro","id":"IPR036056","properties":[{"key":"EntryName","value":"Fibrinogen-like_C"}]},{"database":"InterPro","id":"IPR014716","properties":[{"key":"EntryName","value":"Fibrinogen_a/b/g_C_1"}]},{"database":"InterPro","id":"IPR002181","properties":[{"key":"EntryName","value":"Fibrinogen_a/b/g_C_dom"}]},{"database":"InterPro","id":"IPR012290","properties":[{"key":"EntryName","value":"Fibrinogen_a/b/g_coil_dom"}]},{"database":"InterPro","id":"IPR020837","properties":[{"key":"EntryName","value":"Fibrinogen_CS"}]},{"database":"PANTHER","id":"PTHR47221","properties":[{"key":"EntryName","value":"FIBRINOGEN ALPHA CHAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR47221:SF5","properties":[{"key":"EntryName","value":"FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00147","properties":[{"key":"EntryName","value":"Fibrinogen_C"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00186","properties":[{"key":"EntryName","value":"FBG"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM01212","properties":[{"key":"EntryName","value":"Fib_alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56496","properties":[{"key":"EntryName","value":"Fibrinogen C-terminal domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF58010","properties":[{"key":"EntryName","value":"Fibrinogen coiled-coil and central regions"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00514","properties":[{"key":"EntryName","value":"FIBRINOGEN_C_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51406","properties":[{"key":"EntryName","value":"FIBRINOGEN_C_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MKRMVSWSFHKLKTMKHLLLLLLCVFLVKSQGVNDNEEGFFSARGHRPLDKKREEAPSLRPAPPPISGGGYRARPAKAAATQKKVERKAPDAGGCLHADPDLGVLCPTGCQLQEALLQQERPIRNSVDELNNNVEAVSQTSSSSFQYMYLLKDLWQKRQKQVKDNENVVNEYSSELEKHQLYIDETVNSNIPTNLRVLRSILENLRSKIQKLESDVSAQMEYCRTPCTVSCNIPVVSGKGWTVIQNRQDGSVDFGRKWDPYKQGFGNVATNTDGKNYCGLPGEYWLGNDKISQLTRMGPTELLIEMEDWKGDKVKAHYGGFTVQNEANKYQISVNKYRGTAGNALMDGASQLMGENRTMTIHNGMFFSTYDRDNDGWLTSDPRKQCSKEDGGGWWYNRCHAANPNGRYYWGGQYTWDMAKHGTDDGVVWMNWKGSWYSMRKMSMKIRPFFPQQ","length":453,"molWeight":51560,"crc64":"FC7F8BA7CD4A19F4","md5":"D9686AC6711A6C1D35E0150005755DBA"},"extraAttributes":{"countByCommentType":{"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":1,"Region":1,"Coiled coil":1,"Compositional bias":1,"Disulfide bond":1},"uniParcId":"UPI0040320EF9"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"D6REL8","uniProtkbId":"D6REL8_HUMAN","entryAudit":{"firstPublicDate":"2010-07-13","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2010-07-13","entryVersion":98,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000426757.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00016534"}],"value":"Fibrinogen beta chain"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000426757.1"}],"value":"FGB"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00025974"}],"value":"Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004613"}],"value":"Secreted","id":"SL-0243"}}]}],"features":[{"type":"Domain","location":{"start":{"value":13,"modifier":"EXACT"},"end":{"value":269,"modifier":"EXACT"}},"description":"Fibrinogen C-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51406"}]},{"type":"Disulfide bond","location":{"start":{"value":22,"modifier":"EXACT"},"end":{"value":51,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00739"}]},{"type":"Disulfide bond","location":{"start":{"value":205,"modifier":"EXACT"},"end":{"value":218,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00739"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023084"}],"id":"KW-0094","category":"Biological process","name":"Blood coagulation"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023054"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00739"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022696"}],"id":"KW-0356","category":"Biological process","name":"Hemostasis"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"D6REL8"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"D6REL8"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000426757.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000426757.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15815621","citationType":"journal article","authors":["Hillier L.W.","Graves T.A.","Fulton R.S.","Fulton L.A.","Pepin K.H.","Minx P.","Wagner-McPherson C.","Layman D.","Wylie K.","Sekhon M.","Becker M.C.","Fewell G.A.","Delehaunty K.D.","Miner T.L.","Nash W.E.","Kremitzki C.","Oddy L.","Du H.","Sun H.","Bradshaw-Cordum H.","Ali J.","Carter J.","Cordes M.","Harris A.","Isak A.","van Brunt A.","Nguyen C.","Du F.","Courtney L.","Kalicki J.","Ozersky P.","Abbott S.","Armstrong J.","Belter E.A.","Caruso L.","Cedroni M.","Cotton M.","Davidson T.","Desai A.","Elliott G.","Erb T.","Fronick C.","Gaige T.","Haakenson W.","Haglund K.","Holmes A.","Harkins R.","Kim K.","Kruchowski S.S.","Strong C.M.","Grewal N.","Goyea E.","Hou S.","Levy A.","Martinka S.","Mead K.","McLellan M.D.","Meyer R.","Randall-Maher J.","Tomlinson C.","Dauphin-Kohlberg S.","Kozlowicz-Reilly A.","Shah N.","Swearengen-Shahid S.","Snider J.","Strong J.T.","Thompson J.","Yoakum M.","Leonard S.","Pearman C.","Trani L.","Radionenko M.","Waligorski J.E.","Wang C.","Rock S.M.","Tin-Wollam A.M.","Maupin R.","Latreille P.","Wendl M.C.","Yang S.P.","Pohl C.","Wallis J.W.","Spieth J.","Bieri T.A.","Berkowicz N.","Nelson J.O.","Osborne J.","Ding L.","Meyer R.","Sabo A.","Shotland Y.","Sinha P.","Wohldmann P.E.","Cook L.L.","Hickenbotham M.T.","Eldred J.","Williams D.","Jones T.A.","She X.","Ciccarelli F.D.","Izaurralde E.","Taylor J.","Schmutz J.","Myers R.M.","Cox D.R.","Huang X.","McPherson J.D.","Mardis E.R.","Clifton S.W.","Warren W.C.","Chinwalla A.T.","Eddy S.R.","Marra M.A.","Ovcharenko I.","Furey T.S.","Miller W.","Eichler E.E.","Bork P.","Suyama M.","Torrents D.","Waterston R.H.","Wilson R.K."],"citationCrossReferences":[{"database":"PubMed","id":"15815621"},{"database":"DOI","id":"10.1038/nature03466"}],"title":"Generation and annotation of the DNA sequences of human chromosomes 2 and 4.","publicationDate":"2005","journal":"Nature","firstPage":"724","lastPage":"731","volume":"434"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000426757.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Burckstummer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"21269460"}]},{"referenceNumber":5,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"24275569"}]},{"referenceNumber":6,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000426757.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC107385","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"D6REL8","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"D6REL8","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"D6REL8","properties":[{"key":"Description","value":"-"}]},{"database":"PRIDE","id":"D6REL8","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"14334","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"855","properties":[{"key":"antibodies","value":"636 antibodies from 40 providers"}]},{"database":"Ensembl","id":"ENST00000509493.1","properties":[{"key":"ProteinId","value":"ENSP00000426757.1"},{"key":"GeneId","value":"ENSG00000171564.13"}]},{"database":"UCSC","id":"uc063ajr.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:3662","properties":[{"key":"GeneName","value":"FGB"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000171564","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000158122","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_038628_6_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"GCIHADP","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9930906at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"FGB","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 4"}]},{"database":"Bgee","id":"ENSG00000171564","properties":[{"key":"ExpressionPatterns","value":"Expressed in right lobe of liver and 119 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"D6REL8","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005783","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0007596","properties":[{"key":"GoTerm","value":"P:blood coagulation"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd00087","properties":[{"key":"EntryName","value":"FReD"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.215.10:FF:000006","properties":[{"key":"EntryName","value":"Fibrinogen beta chain"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"4.10.530.10:FF:000004","properties":[{"key":"EntryName","value":"Fibrinogen beta chain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.90.215.10","properties":[{"key":"EntryName","value":"Gamma Fibrinogen, chain A, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"4.10.530.10","properties":[{"key":"EntryName","value":"Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR037579","properties":[{"key":"EntryName","value":"FIB_ANG-like"}]},{"database":"InterPro","id":"IPR036056","properties":[{"key":"EntryName","value":"Fibrinogen-like_C"}]},{"database":"InterPro","id":"IPR014716","properties":[{"key":"EntryName","value":"Fibrinogen_a/b/g_C_1"}]},{"database":"InterPro","id":"IPR002181","properties":[{"key":"EntryName","value":"Fibrinogen_a/b/g_C_dom"}]},{"database":"InterPro","id":"IPR020837","properties":[{"key":"EntryName","value":"Fibrinogen_CS"}]},{"database":"NCBIfam","id":"NF040941","properties":[{"key":"EntryName","value":"GGGWT_bact"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR47221","properties":[{"key":"EntryName","value":"FIBRINOGEN ALPHA CHAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR47221:SF5","properties":[{"key":"EntryName","value":"FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00147","properties":[{"key":"EntryName","value":"Fibrinogen_C"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00186","properties":[{"key":"EntryName","value":"FBG"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56496","properties":[{"key":"EntryName","value":"Fibrinogen C-terminal domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00514","properties":[{"key":"EntryName","value":"FIBRINOGEN_C_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51406","properties":[{"key":"EntryName","value":"FIBRINOGEN_C_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MEYCRTPCTVSCNIPVVSGKECEEIIRKGGETSEMYLIQPDSSVKPYRVYCDMNTENGGWTVIQNRQDGSVDFGRKWDPYKQGFGNVATNTDGKNYCGLPGEYWLGNDKISQLTRMGPTELLIEMEDWKGDKVKAHYGGFTVQNEANKYQISVNKYRGTAGNALMDGASQLMGENRTMTIHNGMFFSTYDRDNDGWLTSDPRKQCSKEDGGGWWYNRCHAANPNGRYYWGGQYTWDMAKHGTDDGVVWMNWKGSWYSMRKMSMKIRPFFPQQ","length":272,"molWeight":31180,"crc64":"6133427AB40E24AA","md5":"33C51724D9CFF720B57C1E7671DD5032"},"extraAttributes":{"countByCommentType":{"SUBUNIT":1,"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Domain":1,"Disulfide bond":2},"uniParcId":"UPI0001D3B996"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"F8W6P4","uniProtkbId":"F8W6P4_HUMAN","entryAudit":{"firstPublicDate":"2011-09-21","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-09-21","entryVersion":60,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000398719.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000398719.1"}],"value":"Fibrinogen beta chain"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000398719.1"}],"value":"FGB"}}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":30,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":31,"modifier":"EXACT"},"end":{"value":45,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5003385510"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"F8W6P4"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000398719.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000398719.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15815621","citationType":"journal article","authors":["Hillier L.W.","Graves T.A.","Fulton R.S.","Fulton L.A.","Pepin K.H.","Minx P.","Wagner-McPherson C.","Layman D.","Wylie K.","Sekhon M.","Becker M.C.","Fewell G.A.","Delehaunty K.D.","Miner T.L.","Nash W.E.","Kremitzki C.","Oddy L.","Du H.","Sun H.","Bradshaw-Cordum H.","Ali J.","Carter J.","Cordes M.","Harris A.","Isak A.","van Brunt A.","Nguyen C.","Du F.","Courtney L.","Kalicki J.","Ozersky P.","Abbott S.","Armstrong J.","Belter E.A.","Caruso L.","Cedroni M.","Cotton M.","Davidson T.","Desai A.","Elliott G.","Erb T.","Fronick C.","Gaige T.","Haakenson W.","Haglund K.","Holmes A.","Harkins R.","Kim K.","Kruchowski S.S.","Strong C.M.","Grewal N.","Goyea E.","Hou S.","Levy A.","Martinka S.","Mead K.","McLellan M.D.","Meyer R.","Randall-Maher J.","Tomlinson C.","Dauphin-Kohlberg S.","Kozlowicz-Reilly A.","Shah N.","Swearengen-Shahid S.","Snider J.","Strong J.T.","Thompson J.","Yoakum M.","Leonard S.","Pearman C.","Trani L.","Radionenko M.","Waligorski J.E.","Wang C.","Rock S.M.","Tin-Wollam A.M.","Maupin R.","Latreille P.","Wendl M.C.","Yang S.P.","Pohl C.","Wallis J.W.","Spieth J.","Bieri T.A.","Berkowicz N.","Nelson J.O.","Osborne J.","Ding L.","Meyer R.","Sabo A.","Shotland Y.","Sinha P.","Wohldmann P.E.","Cook L.L.","Hickenbotham M.T.","Eldred J.","Williams D.","Jones T.A.","She X.","Ciccarelli F.D.","Izaurralde E.","Taylor J.","Schmutz J.","Myers R.M.","Cox D.R.","Huang X.","McPherson J.D.","Mardis E.R.","Clifton S.W.","Warren W.C.","Chinwalla A.T.","Eddy S.R.","Marra M.A.","Ovcharenko I.","Furey T.S.","Miller W.","Eichler E.E.","Bork P.","Suyama M.","Torrents D.","Waterston R.H.","Wilson R.K."],"citationCrossReferences":[{"database":"PubMed","id":"15815621"},{"database":"DOI","id":"10.1038/nature03466"}],"title":"Generation and annotation of the DNA sequences of human chromosomes 2 and 4.","publicationDate":"2005","journal":"Nature","firstPage":"724","lastPage":"731","volume":"434"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000398719.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000398719.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC107385","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"F8W6P4","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"F8W6P4","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000425838.5","properties":[{"key":"ProteinId","value":"ENSP00000398719.1"},{"key":"GeneId","value":"ENSG00000171564.13"}]},{"database":"UCSC","id":"uc063ajq.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:3662","properties":[{"key":"GeneName","value":"FGB"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000171564","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000158122","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_3207412_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"9930906at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"FGB","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 4"}]},{"database":"Bgee","id":"ENSG00000171564","properties":[{"key":"ExpressionPatterns","value":"Expressed in right lobe of liver and 119 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"F8W6P4","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]}],"sequence":{"value":"MKRMVSWSFHKLKTMKHLLLLLLCVFLVKSQGVNDNEEMRKLGHR","length":45,"molWeight":5397,"crc64":"5B1E7DE8196E6406","md5":"299FE5C3E01FC5833EC24470225A19F1"},"extraAttributes":{"countByFeatureType":{"Signal":1,"Chain":1},"uniParcId":"UPI0001D3B995"}}]}