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FBXO31 specifically recognizes and binds C-terminal peptides bearing an amide: C-terminal amidation in response to oxidative stress takes place following protein fragmentation (PubMed:39880951). The SCF(FBXO31) also plays a role in G1 arrest following DNA damage by mediating ubiquitination of phosphorylated cyclin-D1 (CCND1), promoting its degradation by the proteasome, resulting in G1 arrest (PubMed:19412162, PubMed:29279382). The SCF(FBXO31) complex is however not a major regulator of CCND1 stability during the G1/S transition (By similarity). In response to genotoxic stress, the SCF(FBXO31) complex directs ubiquitination and degradation of phosphorylated MDM2, thereby promoting p53/TP53-mediated DNA damage response (PubMed:26124108). SCF(FBXO31) complex is required for genomic integrity by catalyzing ubiquitination and degradation of cyclin-A (CCNA1 and/or CCNA2) during the G1 phase (PubMed:31413110). In response to genotoxic stress, the SCF(FBXO31) complex directs ubiquitination and degradation of phosphorylated FBXO46 and MAP2K6 (PubMed:24936062, PubMed:30171069). SCF(FBXO31) complex promotes ubiquitination and degradation of CDT1 during the G2 phase to prevent re-replication (PubMed:24828503). The SCF(FBXO31) complex also mediates ubiquitination and degradation of DUSP6, OGT and PARD6A (PubMed:23469015, PubMed:34686346, PubMed:39894887)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19412162"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23469015"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24828503"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24936062"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29279382"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31413110"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34686346"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"39880951"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"39894887"}],"value":"Protein modification; protein ubiquitination"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16357137"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19412162"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29343641"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31413110"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"39880951"}],"value":"Part of a SCF (SKP1-cullin-F-box) protein ligase complex SCF(FBXO31) composed of CUL1, SKP1, RBX1 and FBXO31 (PubMed:16357137, PubMed:19412162, PubMed:31413110, PubMed:39880951). 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