{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9Y4F1","secondaryAccessions":["Q5JVI9","Q6IQ29"],"uniProtkbId":"FARP1_HUMAN","entryAudit":{"firstPublicDate":"2006-04-18","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1999-11-01","entryVersion":198,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"FERM, ARHGEF and pleckstrin domain-containing protein 1"}},"alternativeNames":[{"fullName":{"value":"Chondrocyte-derived ezrin-like protein"}},{"fullName":{"value":"FERM, RhoGEF and pleckstrin domain-containing protein 1"}},{"fullName":{"value":"Pleckstrin homology domain-containing family C member 2"},"shortNames":[{"value":"PH domain-containing family C member 2"}]}]},"genes":[{"geneName":{"value":"FARP1"},"synonyms":[{"value":"CDEP"},{"value":"PLEKHC2"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Functions as a guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Interacts with CADM1. Interacts with RAC1 (By similarity)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q9Y4F1","intActId":"EBI-5235630"},"interactantTwo":{"uniProtKBAccession":"Q9NWS0","geneName":"PIH1D1","intActId":"EBI-357318"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Recruited to the cell membrane via interaction with CADM1"}]},"subcellularLocations":[{"location":{"value":"Cell membrane","id":"SL-0039"},"topology":{"value":"Peripheral membrane protein","id":"SL-9903"},"orientation":{"value":"Cytoplasmic side","id":"SL-9910"}},{"location":{"value":"Synapse","id":"SL-0258"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Synapse, synaptosome","id":"SL-0261"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Cytoplasm, cytosol","id":"SL-0091"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Cell projection, filopodium","id":"SL-0286"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Cell projection, dendrite","id":"SL-0283"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Cell projection, dendritic spine","id":"SL-0284"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q9Y4F1-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q9Y4F1-2"],"sequenceIds":["VSP_017976"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"isoformIds":["Q9Y4F1-3"],"sequenceIds":["VSP_040989","VSP_040990"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9425278"}],"value":"Detected in cAMP-treated chondrocytes, but not in untreated chondrocytes. Detected in fetal brain, heart and spleen, and in adult testis, kidney and lung"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9425278"}],"value":"Up-regulated in response to cAMP in cultured embryonic chondrocytes"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23375260"}],"value":"Intramolecular interaction between the DH domain and the PH domains can stabilize the protein in an autoinhibited conformation"}],"commentType":"DOMAIN"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1045,"modifier":"EXACT"}},"description":"FERM, ARHGEF and pleckstrin domain-containing protein 1","featureId":"PRO_0000232753"},{"type":"Domain","location":{"start":{"value":40,"modifier":"EXACT"},"end":{"value":320,"modifier":"EXACT"}},"description":"FERM","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00084"}]},{"type":"Domain","location":{"start":{"value":540,"modifier":"EXACT"},"end":{"value":730,"modifier":"EXACT"}},"description":"DH","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00062"}]},{"type":"Domain","location":{"start":{"value":759,"modifier":"EXACT"},"end":{"value":856,"modifier":"EXACT"}},"description":"PH 1","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00145"}]},{"type":"Domain","location":{"start":{"value":932,"modifier":"EXACT"},"end":{"value":1029,"modifier":"EXACT"}},"description":"PH 2","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00145"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":37,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":361,"modifier":"EXACT"},"end":{"value":534,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":864,"modifier":"EXACT"},"end":{"value":903,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":373,"modifier":"EXACT"},"end":{"value":396,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":471,"modifier":"EXACT"},"end":{"value":489,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":496,"modifier":"EXACT"},"end":{"value":511,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":20,"modifier":"EXACT"},"end":{"value":20,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"F8VPU2"}]},{"type":"Modified residue","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":23,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"F8VPU2"}]},{"type":"Modified residue","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":24,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":340,"modifier":"EXACT"},"end":{"value":340,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"}]},{"type":"Modified residue","location":{"start":{"value":373,"modifier":"EXACT"},"end":{"value":373,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Modified residue","location":{"start":{"value":389,"modifier":"EXACT"},"end":{"value":389,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"F8VPU2"}]},{"type":"Modified residue","location":{"start":{"value":403,"modifier":"EXACT"},"end":{"value":403,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Modified residue","location":{"start":{"value":418,"modifier":"EXACT"},"end":{"value":418,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Modified residue","location":{"start":{"value":427,"modifier":"EXACT"},"end":{"value":427,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"17924679"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18220336"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Modified residue","location":{"start":{"value":433,"modifier":"EXACT"},"end":{"value":433,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"F8VPU2"}]},{"type":"Modified residue","location":{"start":{"value":510,"modifier":"EXACT"},"end":{"value":510,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"}]},{"type":"Modified residue","location":{"start":{"value":514,"modifier":"EXACT"},"end":{"value":514,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"}]},{"type":"Modified residue","location":{"start":{"value":833,"modifier":"EXACT"},"end":{"value":833,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Modified residue","location":{"start":{"value":872,"modifier":"EXACT"},"end":{"value":872,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Modified residue","location":{"start":{"value":878,"modifier":"EXACT"},"end":{"value":878,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"F8VPU2"}]},{"type":"Modified residue","location":{"start":{"value":883,"modifier":"EXACT"},"end":{"value":883,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Modified residue","location":{"start":{"value":889,"modifier":"EXACT"},"end":{"value":889,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18318008"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Modified residue","location":{"start":{"value":896,"modifier":"EXACT"},"end":{"value":896,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"F8VPU2"}]},{"type":"Modified residue","location":{"start":{"value":899,"modifier":"EXACT"},"end":{"value":899,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"F8VPU2"}]},{"type":"Alternative sequence","location":{"start":{"value":58,"modifier":"EXACT"},"end":{"value":129,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_040989","alternativeSequence":{"originalSequence":"QRAPGKVLLDAVCNHLNLVEGDYFGLEFPDHKKITVWLDLLKPIVKQIRRPKHVVVKFVVKFFPPDHTQLQE","alternativeSequences":["MVSSSSFLKATGSSWTGWVLRCSMKPKHHSHLIEKFGEDRILTHLTGSISYTNWAGSRSLAVTVTEELLNLF"]}},{"type":"Alternative sequence","location":{"start":{"value":130,"modifier":"EXACT"},"end":{"value":1045,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_040990","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":758,"modifier":"EXACT"},"end":{"value":758,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_017976","alternativeSequence":{"originalSequence":"R","alternativeSequences":["RPGSFSLMRTPHLGQARRIPCAPERRPLLLVK"]}},{"type":"Natural variant","location":{"start":{"value":8,"modifier":"EXACT"},"end":{"value":8,"modifier":"EXACT"}},"description":"in dbSNP:rs9300466","featureCrossReferences":[{"database":"dbSNP","id":"rs9300466"}],"featureId":"VAR_048362","alternativeSequence":{"originalSequence":"P","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":714,"modifier":"EXACT"},"end":{"value":714,"modifier":"EXACT"}},"description":"in a breast cancer sample; somatic mutation; dbSNP:rs1458028855","featureCrossReferences":[{"database":"dbSNP","id":"rs1458028855"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16959974"}],"featureId":"VAR_035851","alternativeSequence":{"originalSequence":"R","alternativeSequences":["L"]}},{"type":"Sequence conflict","location":{"start":{"value":644,"modifier":"EXACT"},"end":{"value":644,"modifier":"EXACT"}},"description":"in Ref. 3; AAH71592","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"H","alternativeSequences":["Y"]}}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0217","category":"Molecular function","name":"Developmental protein"},{"id":"KW-0344","category":"Molecular function","name":"Guanine-nucleotide releasing factor"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0677","category":"Domain","name":"Repeat"},{"id":"KW-0770","category":"Cellular component","name":"Synapse"},{"id":"KW-0771","category":"Cellular component","name":"Synaptosome"}],"references":[{"referenceNumber":1,"citation":{"id":"9425278","citationType":"journal article","authors":["Koyano Y.","Kawamoto T.","Shen M.","Yan W.","Noshiro M.","Fujii K.","Kato Y."],"citationCrossReferences":[{"database":"PubMed","id":"9425278"},{"database":"DOI","id":"10.1006/bbrc.1997.7826"}],"title":"Molecular cloning and characterization of CDEP, a novel human protein containing the ezrin-like domain of the band 4.1 superfamily and the Dbl homology domain of rho guanine nucleotide exchange factors.","publicationDate":"1997","journal":"Biochem. Biophys. Res. Commun.","firstPage":"369","lastPage":"375","volume":"241"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)","INDUCTION","TISSUE SPECIFICITY"],"referenceComments":[{"value":"Cartilage","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"15057823","citationType":"journal article","authors":["Dunham A.","Matthews L.H.","Burton J.","Ashurst J.L.","Howe K.L.","Ashcroft K.J.","Beare D.M.","Burford D.C.","Hunt S.E.","Griffiths-Jones S.","Jones M.C.","Keenan S.J.","Oliver K.","Scott C.E.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Andrews D.T.","Ashwell R.I.S.","Babbage A.K.","Bagguley C.L.","Bailey J.","Bannerjee R.","Barlow K.F.","Bates K.","Beasley H.","Bird C.P.","Bray-Allen S.","Brown A.J.","Brown J.Y.","Burrill W.","Carder C.","Carter N.P.","Chapman J.C.","Clamp M.E.","Clark S.Y.","Clarke G.","Clee C.M.","Clegg S.C.","Cobley V.","Collins J.E.","Corby N.","Coville G.J.","Deloukas P.","Dhami P.","Dunham I.","Dunn M.","Earthrowl M.E.","Ellington A.G.","Faulkner L.","Frankish A.G.","Frankland J.","French L.","Garner P.","Garnett J.","Gilbert J.G.R.","Gilson C.J.","Ghori J.","Grafham D.V.","Gribble S.M.","Griffiths C.","Hall R.E.","Hammond S.","Harley J.L.","Hart E.A.","Heath P.D.","Howden P.J.","Huckle E.J.","Hunt P.J.","Hunt A.R.","Johnson C.","Johnson D.","Kay M.","Kimberley A.M.","King A.","Laird G.K.","Langford C.J.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Lloyd C.","Loveland J.E.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","McLaren S.J.","McMurray A.","Milne S.","Moore M.J.F.","Nickerson T.","Palmer S.A.","Pearce A.V.","Peck A.I.","Pelan S.","Phillimore B.","Porter K.M.","Rice C.M.","Searle S.","Sehra H.K.","Shownkeen R.","Skuce C.D.","Smith M.","Steward C.A.","Sycamore N.","Tester J.","Thomas D.W.","Tracey A.","Tromans A.","Tubby B.","Wall M.","Wallis J.M.","West A.P.","Whitehead S.L.","Willey D.L.","Wilming L.","Wray P.W.","Wright M.W.","Young L.","Coulson A.","Durbin R.M.","Hubbard T.","Sulston J.E.","Beck S.","Bentley D.R.","Rogers J.","Ross M.T."],"citationCrossReferences":[{"database":"PubMed","id":"15057823"},{"database":"DOI","id":"10.1038/nature02379"}],"title":"The DNA sequence and analysis of human chromosome 13.","publicationDate":"2004","journal":"Nature","firstPage":"522","lastPage":"528","volume":"428"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":3,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3)"],"referenceComments":[{"value":"Brain","type":"TISSUE"},{"value":"Placenta","type":"TISSUE"},{"value":"Skin","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"17081983","citationType":"journal article","authors":["Olsen J.V.","Blagoev B.","Gnad F.","Macek B.","Kumar C.","Mortensen P.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"17081983"},{"database":"DOI","id":"10.1016/j.cell.2006.09.026"}],"title":"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.","publicationDate":"2006","journal":"Cell","firstPage":"635","lastPage":"648","volume":"127"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"17924679","citationType":"journal article","authors":["Yu L.R.","Zhu Z.","Chan K.C.","Issaq H.J.","Dimitrov D.S.","Veenstra T.D."],"citationCrossReferences":[{"database":"PubMed","id":"17924679"},{"database":"DOI","id":"10.1021/pr070152u"}],"title":"Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.","publicationDate":"2007","journal":"J. Proteome Res.","firstPage":"4150","lastPage":"4162","volume":"6"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-427","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":6,"citation":{"id":"18220336","citationType":"journal article","authors":["Cantin G.T.","Yi W.","Lu B.","Park S.K.","Xu T.","Lee J.-D.","Yates J.R. III"],"citationCrossReferences":[{"database":"PubMed","id":"18220336"},{"database":"DOI","id":"10.1021/pr0705441"}],"title":"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.","publicationDate":"2008","journal":"J. Proteome Res.","firstPage":"1346","lastPage":"1351","volume":"7"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-427","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":7,"citation":{"id":"18669648","citationType":"journal article","authors":["Dephoure N.","Zhou C.","Villen J.","Beausoleil S.A.","Bakalarski C.E.","Elledge S.J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"18669648"},{"database":"DOI","id":"10.1073/pnas.0805139105"}],"title":"A quantitative atlas of mitotic phosphorylation.","publicationDate":"2008","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10762","lastPage":"10767","volume":"105"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-24 AND SER-340","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":8,"citation":{"id":"18318008","citationType":"journal article","authors":["Han G.","Ye M.","Zhou H.","Jiang X.","Feng S.","Jiang X.","Tian R.","Wan D.","Zou H.","Gu J."],"citationCrossReferences":[{"database":"PubMed","id":"18318008"},{"database":"DOI","id":"10.1002/pmic.200700884"}],"title":"Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.","publicationDate":"2008","journal":"Proteomics","firstPage":"1346","lastPage":"1361","volume":"8"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-889","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":9,"citation":{"id":"19413330","citationType":"journal article","authors":["Gauci S.","Helbig A.O.","Slijper M.","Krijgsveld J.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"19413330"},{"database":"DOI","id":"10.1021/ac9004309"}],"title":"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.","publicationDate":"2009","journal":"Anal. Chem.","firstPage":"4493","lastPage":"4501","volume":"81"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":10,"citation":{"id":"20068231","citationType":"journal article","authors":["Olsen J.V.","Vermeulen M.","Santamaria A.","Kumar C.","Miller M.L.","Jensen L.J.","Gnad F.","Cox J.","Jensen T.S.","Nigg E.A.","Brunak S.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"20068231"},{"database":"DOI","id":"10.1126/scisignal.2000475"}],"title":"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.","publicationDate":"2010","journal":"Sci. Signal.","firstPage":"RA3","lastPage":"RA3","volume":"3"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-24; SER-427; SER-510 AND SER-514","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":11,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Buerckstuemmer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":12,"citation":{"id":"21406692","citationType":"journal article","authors":["Rigbolt K.T.","Prokhorova T.A.","Akimov V.","Henningsen J.","Johansen P.T.","Kratchmarova I.","Kassem M.","Mann M.","Olsen J.V.","Blagoev B."],"citationCrossReferences":[{"database":"PubMed","id":"21406692"},{"database":"DOI","id":"10.1126/scisignal.2001570"}],"title":"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.","publicationDate":"2011","journal":"Sci. Signal.","firstPage":"RS3","lastPage":"RS3","volume":"4"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-872 AND SER-889","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":13,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"},{"database":"DOI","id":"10.1021/pr300630k"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-24","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":14,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-373; SER-403; SER-418; SER-427; SER-833; SER-872; THR-883 AND SER-889","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":15,"citation":{"id":"23375260","citationType":"journal article","authors":["He X.","Kuo Y.C.","Rosche T.J.","Zhang X."],"citationCrossReferences":[{"database":"PubMed","id":"23375260"},{"database":"DOI","id":"10.1016/j.str.2013.01.001"}],"title":"Structural basis for autoinhibition of the guanine nucleotide exchange factor FARP2.","publicationDate":"2013","journal":"Structure","firstPage":"355","lastPage":"364","volume":"21"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (4.09 ANGSTROMS) OF 539-1035","DOMAIN"]},{"referenceNumber":16,"citation":{"id":"16959974","citationType":"journal article","authors":["Sjoeblom T.","Jones S.","Wood L.D.","Parsons D.W.","Lin J.","Barber T.D.","Mandelker D.","Leary R.J.","Ptak J.","Silliman N.","Szabo S.","Buckhaults P.","Farrell C.","Meeh P.","Markowitz S.D.","Willis J.","Dawson D.","Willson J.K.V.","Gazdar A.F.","Hartigan J.","Wu L.","Liu C.","Parmigiani G.","Park B.H.","Bachman K.E.","Papadopoulos N.","Vogelstein B.","Kinzler K.W.","Velculescu V.E."],"citationCrossReferences":[{"database":"PubMed","id":"16959974"},{"database":"DOI","id":"10.1126/science.1133427"}],"title":"The consensus coding sequences of human breast and colorectal cancers.","publicationDate":"2006","journal":"Science","firstPage":"268","lastPage":"274","volume":"314"},"referencePositions":["VARIANT [LARGE SCALE ANALYSIS] LEU-714"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AB008430","properties":[{"key":"ProteinId","value":"BAA24267.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AL136300","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL137249","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL161896","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL445223","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC041595","properties":[{"key":"ProteinId","value":"AAH41595.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC065020","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC071592","properties":[{"key":"ProteinId","value":"AAH71592.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS32000.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9Y4F1-3"},{"database":"CCDS","id":"CCDS66572.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9Y4F1-2"},{"database":"CCDS","id":"CCDS9487.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9Y4F1-1"},{"database":"PIR","id":"JC5795","properties":[{"key":"EntryName","value":"JC5795"}]},{"database":"RefSeq","id":"NP_001001715.2","properties":[{"key":"NucleotideSequenceId","value":"NM_001001715.4"}],"isoformId":"Q9Y4F1-3"},{"database":"RefSeq","id":"NP_001273768.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001286839.2"}]},{"database":"RefSeq","id":"NP_005757.1","properties":[{"key":"NucleotideSequenceId","value":"NM_005766.4"}],"isoformId":"Q9Y4F1-1"},{"database":"PDB","id":"4H6Y","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"4.09 A"},{"key":"Chains","value":"A/B=539-1035"}]},{"database":"PDBsum","id":"4H6Y","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"Q9Y4F1","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q9Y4F1","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"115462","properties":[{"key":"Interactions","value":"161"}]},{"database":"FunCoup","id":"Q9Y4F1","properties":[{"key":"Number of interactors","value":"821"}]},{"database":"IntAct","id":"Q9Y4F1","properties":[{"key":"Interactions","value":"88"}]},{"database":"MINT","id":"Q9Y4F1","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-FARP1","properties":[{"key":"Evidences","value":"1 NDEx IQuery Curated Pathway"}]},{"database":"STRING","id":"9606.ENSP00000486285","properties":[{"key":"Description","value":"-"}]},{"database":"CarbonylDB","id":"Q9Y4F1","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"Q9Y4F1","properties":[{"key":"glycosylation","value":"2 sites, 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"Q9Y4F1","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q9Y4F1","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"Q9Y4F1","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"FARP1","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"74762059","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q9Y4F1","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q9Y4F1","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000486285","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q9Y4F1","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"86186","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9Y4F1-1"},{"database":"ProteomicsDB","id":"86187","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9Y4F1-2"},{"database":"ProteomicsDB","id":"86188","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9Y4F1-3"},{"database":"Pumba","id":"Q9Y4F1","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"619","properties":[{"key":"antibodies","value":"214 antibodies from 21 providers"}]},{"database":"DNASU","id":"10160","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000319562.11","properties":[{"key":"ProteinId","value":"ENSP00000322926.6"},{"key":"GeneId","value":"ENSG00000152767.18"}],"isoformId":"Q9Y4F1-1"},{"database":"Ensembl","id":"ENST00000376581.9","properties":[{"key":"ProteinId","value":"ENSP00000365765.4"},{"key":"GeneId","value":"ENSG00000152767.18"}],"isoformId":"Q9Y4F1-3"},{"database":"Ensembl","id":"ENST00000871496.1","properties":[{"key":"ProteinId","value":"ENSP00000541555.1"},{"key":"GeneId","value":"ENSG00000152767.18"}],"isoformId":"Q9Y4F1-1"},{"database":"Ensembl","id":"ENST00000871497.1","properties":[{"key":"ProteinId","value":"ENSP00000541556.1"},{"key":"GeneId","value":"ENSG00000152767.18"}],"isoformId":"Q9Y4F1-1"},{"database":"Ensembl","id":"ENST00000871500.1","properties":[{"key":"ProteinId","value":"ENSP00000541559.1"},{"key":"GeneId","value":"ENSG00000152767.18"}],"isoformId":"Q9Y4F1-1"},{"database":"Ensembl","id":"ENST00000871503.1","properties":[{"key":"ProteinId","value":"ENSP00000541562.1"},{"key":"GeneId","value":"ENSG00000152767.18"}],"isoformId":"Q9Y4F1-1"},{"database":"Ensembl","id":"ENST00000871506.1","properties":[{"key":"ProteinId","value":"ENSP00000541565.1"},{"key":"GeneId","value":"ENSG00000152767.18"}],"isoformId":"Q9Y4F1-1"},{"database":"Ensembl","id":"ENST00000922582.1","properties":[{"key":"ProteinId","value":"ENSP00000592641.1"},{"key":"GeneId","value":"ENSG00000152767.18"}],"isoformId":"Q9Y4F1-1"},{"database":"Ensembl","id":"ENST00000922585.1","properties":[{"key":"ProteinId","value":"ENSP00000592644.1"},{"key":"GeneId","value":"ENSG00000152767.18"}],"isoformId":"Q9Y4F1-1"},{"database":"Ensembl","id":"ENST00000922586.1","properties":[{"key":"ProteinId","value":"ENSP00000592645.1"},{"key":"GeneId","value":"ENSG00000152767.18"}],"isoformId":"Q9Y4F1-1"},{"database":"GeneID","id":"10160","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:10160","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000319562.11","properties":[{"key":"ProteinId","value":"ENSP00000322926.6"},{"key":"RefSeqNucleotideId","value":"NM_005766.4"},{"key":"RefSeqProteinId","value":"NP_005757.1"}]},{"database":"UCSC","id":"uc001vni.5","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"Q9Y4F1-1"},{"database":"AGR","id":"HGNC:3591","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA28004","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"10160","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"10160","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"FARP1","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:3591","properties":[{"key":"GeneName","value":"FARP1"}]},{"database":"HPA","id":"ENSG00000152767","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MIM","id":"602654","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000152767","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000152767","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG3531","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000155318","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_012301_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q9Y4F1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"9990815at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q9Y4F1","properties":[{"key":"Number of GO annotations","value":"1 GO annotation based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q9Y4F1","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q9Y4F1","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-8980692","properties":[{"key":"PathwayName","value":"RHOA GTPase cycle"}]},{"database":"Reactome","id":"R-HSA-9013148","properties":[{"key":"PathwayName","value":"CDC42 GTPase cycle"}]},{"database":"Reactome","id":"R-HSA-9013149","properties":[{"key":"PathwayName","value":"RAC1 GTPase cycle"}]},{"database":"Reactome","id":"R-HSA-9035034","properties":[{"key":"PathwayName","value":"RHOF GTPase cycle"}]},{"database":"SignaLink","id":"Q9Y4F1","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000152767","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"10160","properties":[{"key":"hits","value":"15 hits in 1145 CRISPR screens"}]},{"database":"CD-CODE","id":"FB4E32DD","properties":[{"key":"EntryName","value":"Presynaptic clusters and postsynaptic densities"}]},{"database":"ChiTaRS","id":"FARP1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"Q9Y4F1","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"FARP1","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"10160","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q9Y4F1","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:Q9Y4F1","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 13"}]},{"database":"RNAct","id":"Q9Y4F1","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000152767","properties":[{"key":"ExpressionPatterns","value":"Expressed in renal medulla and 204 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q9Y4F1","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0009898","properties":[{"key":"GoTerm","value":"C:cytoplasmic side of plasma membrane"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0005856","properties":[{"key":"GoTerm","value":"C:cytoskeleton"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"9425278"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0030425","properties":[{"key":"GoTerm","value":"C:dendrite"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0043197","properties":[{"key":"GoTerm","value":"C:dendritic spine"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0098890","properties":[{"key":"GoTerm","value":"C:extrinsic component of postsynaptic membrane"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0030175","properties":[{"key":"GoTerm","value":"C:filopodium"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0098978","properties":[{"key":"GoTerm","value":"C:glutamatergic synapse"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0008092","properties":[{"key":"GoTerm","value":"F:cytoskeletal protein binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0005085","properties":[{"key":"GoTerm","value":"F:guanyl-nucleotide exchange factor activity"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0031267","properties":[{"key":"GoTerm","value":"F:small GTPase binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0048813","properties":[{"key":"GoTerm","value":"P:dendrite morphogenesis"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0007167","properties":[{"key":"GoTerm","value":"P:enzyme-linked receptor protein signaling pathway"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0098974","properties":[{"key":"GoTerm","value":"P:postsynaptic actin cytoskeleton organization"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0016601","properties":[{"key":"GoTerm","value":"P:Rac protein signal transduction"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:1905606","properties":[{"key":"GoTerm","value":"P:regulation of presynapse assembly"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0098942","properties":[{"key":"GoTerm","value":"P:retrograde trans-synaptic signaling by trans-synaptic protein complex"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0007416","properties":[{"key":"GoTerm","value":"P:synapse assembly"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"CDD","id":"cd14473","properties":[{"key":"EntryName","value":"FERM_B-lobe"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd13193","properties":[{"key":"EntryName","value":"FERM_C_FARP1-like"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd01220","properties":[{"key":"EntryName","value":"PH1_FARP1-like"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd13235","properties":[{"key":"EntryName","value":"PH2_FARP1-like"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd00160","properties":[{"key":"EntryName","value":"RhoGEF"},{"key":"MatchStatus","value":"1"}]},{"database":"DisProt","id":"DP02833","properties":[{"key":"Description","value":"-"}]},{"database":"FunFam","id":"2.30.29.30:FF:000002","properties":[{"key":"EntryName","value":"Band 4.1-like protein 5 isoform 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.10.20.90:FF:000040","properties":[{"key":"EntryName","value":"FERM, RhoGEF and pleckstrin domain-containing protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.80.10:FF:000005","properties":[{"key":"EntryName","value":"FERM, RhoGEF and pleckstrin domain-containing protein 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.900.10:FF:000021","properties":[{"key":"EntryName","value":"FERM, RhoGEF and pleckstrin domain-containing protein 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.30.29.30:FF:000046","properties":[{"key":"EntryName","value":"FERM, RhoGEF and pleckstrin domain-containing protein 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.80.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.900.10","properties":[{"key":"EntryName","value":"Dbl homology (DH) domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.10.20.90","properties":[{"key":"EntryName","value":"Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.30.29.30","properties":[{"key":"EntryName","value":"Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"},{"key":"MatchStatus","value":"3"}]},{"database":"InterPro","id":"IPR019749","properties":[{"key":"EntryName","value":"Band_41_domain"}]},{"database":"InterPro","id":"IPR035899","properties":[{"key":"EntryName","value":"DBL_dom_sf"}]},{"database":"InterPro","id":"IPR000219","properties":[{"key":"EntryName","value":"DH_dom"}]},{"database":"InterPro","id":"IPR000798","properties":[{"key":"EntryName","value":"Ez/rad/moesin-like"}]},{"database":"InterPro","id":"IPR014847","properties":[{"key":"EntryName","value":"FA"}]},{"database":"InterPro","id":"IPR041788","properties":[{"key":"EntryName","value":"FARP1/FARP2/FRMD7_FERM_C"}]},{"database":"InterPro","id":"IPR014352","properties":[{"key":"EntryName","value":"FERM/acyl-CoA-bd_prot_sf"}]},{"database":"InterPro","id":"IPR035963","properties":[{"key":"EntryName","value":"FERM_2"}]},{"database":"InterPro","id":"IPR019748","properties":[{"key":"EntryName","value":"FERM_central"}]},{"database":"InterPro","id":"IPR019747","properties":[{"key":"EntryName","value":"FERM_CS"}]},{"database":"InterPro","id":"IPR000299","properties":[{"key":"EntryName","value":"FERM_domain"}]},{"database":"InterPro","id":"IPR018979","properties":[{"key":"EntryName","value":"FERM_N"}]},{"database":"InterPro","id":"IPR018980","properties":[{"key":"EntryName","value":"FERM_PH-like_C"}]},{"database":"InterPro","id":"IPR011993","properties":[{"key":"EntryName","value":"PH-like_dom_sf"}]},{"database":"InterPro","id":"IPR001849","properties":[{"key":"EntryName","value":"PH_domain"}]},{"database":"InterPro","id":"IPR051835","properties":[{"key":"EntryName","value":"RAC1-GEF"}]},{"database":"InterPro","id":"IPR029071","properties":[{"key":"EntryName","value":"Ubiquitin-like_domsf"}]},{"database":"PANTHER","id":"PTHR45858","properties":[{"key":"EntryName","value":"FERM DOMAIN CONTAINING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR45858:SF2","properties":[{"key":"EntryName","value":"FERM, ARHGEF AND PLECKSTRIN DOMAIN-CONTAINING PROTEIN 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08736","properties":[{"key":"EntryName","value":"FA"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF09380","properties":[{"key":"EntryName","value":"FERM_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00373","properties":[{"key":"EntryName","value":"FERM_M"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF09379","properties":[{"key":"EntryName","value":"FERM_N"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00169","properties":[{"key":"EntryName","value":"PH"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF00621","properties":[{"key":"EntryName","value":"RhoGEF"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00935","properties":[{"key":"EntryName","value":"BAND41"}]},{"database":"PRINTS","id":"PR00661","properties":[{"key":"EntryName","value":"ERMFAMILY"}]},{"database":"SMART","id":"SM00295","properties":[{"key":"EntryName","value":"B41"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM01195","properties":[{"key":"EntryName","value":"FA"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM01196","properties":[{"key":"EntryName","value":"FERM_C"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00233","properties":[{"key":"EntryName","value":"PH"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00325","properties":[{"key":"EntryName","value":"RhoGEF"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48065","properties":[{"key":"EntryName","value":"DBL homology domain (DH-domain)"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF50729","properties":[{"key":"EntryName","value":"PH domain-like"},{"key":"MatchStatus","value":"3"}]},{"database":"SUPFAM","id":"SSF47031","properties":[{"key":"EntryName","value":"Second domain of FERM"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54236","properties":[{"key":"EntryName","value":"Ubiquitin-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50010","properties":[{"key":"EntryName","value":"DH_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00660","properties":[{"key":"EntryName","value":"FERM_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50057","properties":[{"key":"EntryName","value":"FERM_3"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50003","properties":[{"key":"EntryName","value":"PH_DOMAIN"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPQRAPGKVLLDAVCNHLNLVEGDYFGLEFPDHKKITVWLDLLKPIVKQIRRPKHVVVKFVVKFFPPDHTQLQEELTRYLFALQVKQDLAQGRLTCNDTSAALLISHIVQSEIGDFDEALDREHLAKNKYIPQQDALEDKIVEFHHNHIGQTPAESDFQLLEIARRLEMYGIRLHPAKDREGTKINLAVANTGILVFQGFTKINAFNWAKVRKLSFKRKRFLIKLRPDANSAYQDTLEFLMASRDFCKSFWKICVEHHAFFRLFEEPKPKPKPVLFSRGSSFRFSGRTQKQVLDYVKEGGHKKVQFERKHSKIHSIRSLASQPTELNSEVLEQSQQSTSLTFGEGAESPGGQSCRRGKEPKVSAGEPGSHPSPAPRRSPAGNKQADGAASAPTEEEEEVVKDRTQQSKPQPPQPSTGSLTGSPHLSELSVNSQGGVAPANVTLSPNLSPDTKQASPLISPLLNDQACPRTDDEDEGRRKRFPTDKAYFIAKEVSTTERTYLKDLEVITSWFQSTVSKEDAMPEALKSLIFPNFEPLHKFHTNFLKEIEQRLALWEGRSNAQIRDYQRIGDVMLKNIQGMKHLAAHLWKHSEALEALENGIKSSRRLENFCRDFELQKVCYLPLNTFLLRPLHRLMHYKQVLERLCKHHPPSHADFRDCRAALAEITEMVAQLHGTMIKMENFQKLHELKKDLIGIDNLVVPGREFIRLGSLSKLSGKGLQQRMFFLFNDVLLYTSRGLTASNQFKVHGQLPLYGMTIEESEDEWGVPHCLTLRGQRQSIIVAASSRSEMEKWVEDIQMAIDLAEKSSSPAPEFLASSPPDNKSPDEATAADQESEDDLSASRTSLERQAPHRGNTMVHVCWHRNTSVSMVDFSIAVENQLSGNLLRKFKNSNGWQKLWVVFTNFCLFFYKSHQDNHPLASLPLLGYSLTIPSESENIQKDYVFKLHFKSHVYYFRAESEYTFERWMEVIRSATSSASRPHVLSHKESLVY","length":1045,"molWeight":118633,"crc64":"0E8B2D61C0F58417","md5":"6D29BC37B49617806B23A18D71AED988"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"INTERACTION":1,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":3,"TISSUE SPECIFICITY":1,"INDUCTION":1,"DOMAIN":1},"countByFeatureType":{"Chain":1,"Domain":4,"Region":3,"Compositional bias":3,"Modified residue":19,"Alternative sequence":3,"Natural variant":2,"Sequence conflict":1},"uniParcId":"UPI000007052C"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"C9JME2","uniProtkbId":"C9JME2_HUMAN","entryAudit":{"firstPublicDate":"2009-11-03","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-06-28","entryVersion":130,"sequenceVersion":2},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000471242.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00040395"}],"value":"FERM, ARHGEF and pleckstrin domain-containing protein 1"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00042170"}],"value":"FERM, RhoGEF and pleckstrin domain-containing protein 1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000471242.1"}],"value":"FARP1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00054998"}],"value":"Functions as a guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00064538"}],"value":"Interacts with CADM1. Interacts with RAC1"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004413"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004413"}],"value":"Peripheral membrane protein","id":"SL-9903"},"orientation":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004413"}],"value":"Cytoplasmic side","id":"SL-9910"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004279"}],"value":"Cell projection, dendrite","id":"SL-0283"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004552"}],"value":"Cell projection, dendritic spine","id":"SL-0284"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004486"}],"value":"Cell projection, filopodium","id":"SL-0286"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004514"}],"value":"Cytoplasm, cytosol","id":"SL-0091"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00034102"}],"value":"Synapse, synaptosome","id":"SL-0261"}}]}],"features":[{"type":"Domain","location":{"start":{"value":40,"modifier":"EXACT"},"end":{"value":320,"modifier":"EXACT"}},"description":"FERM","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50057"}]},{"type":"Domain","location":{"start":{"value":540,"modifier":"EXACT"},"end":{"value":730,"modifier":"EXACT"}},"description":"DH","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50010"}]},{"type":"Domain","location":{"start":{"value":790,"modifier":"EXACT"},"end":{"value":887,"modifier":"EXACT"}},"description":"PH","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50003"}]},{"type":"Domain","location":{"start":{"value":963,"modifier":"EXACT"},"end":{"value":1060,"modifier":"EXACT"}},"description":"PH","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50003"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":37,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":361,"modifier":"EXACT"},"end":{"value":534,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":895,"modifier":"EXACT"},"end":{"value":934,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":373,"modifier":"EXACT"},"end":{"value":396,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":471,"modifier":"EXACT"},"end":{"value":489,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":496,"modifier":"EXACT"},"end":{"value":511,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023273"}],"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022473"}],"id":"KW-0217","category":"Molecular function","name":"Developmental protein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022658"}],"id":"KW-0344","category":"Molecular function","name":"Guanine-nucleotide releasing factor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"C9JME2"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"C9JME2"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023018"}],"id":"KW-0770","category":"Cellular component","name":"Synapse"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022599"}],"id":"KW-0771","category":"Cellular component","name":"Synaptosome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000471242.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15057823","citationType":"journal article","authors":["Dunham A.","Matthews L.H.","Burton J.","Ashurst J.L.","Howe K.L.","Ashcroft K.J.","Beare D.M.","Burford D.C.","Hunt S.E.","Griffiths-Jones S.","Jones M.C.","Keenan S.J.","Oliver K.","Scott C.E.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Andrews D.T.","Ashwell R.I.","Babbage A.K.","Bagguley C.L.","Bailey J.","Bannerjee R.","Barlow K.F.","Bates K.","Beasley H.","Bird C.P.","Bray-Allen S.","Brown A.J.","Brown J.Y.","Burrill W.","Carder C.","Carter N.P.","Chapman J.C.","Clamp M.E.","Clark S.Y.","Clarke G.","Clee C.M.","Clegg S.C.","Cobley V.","Collins J.E.","Corby N.","Coville G.J.","Deloukas P.","Dhami P.","Dunham I.","Dunn M.","Earthrowl M.E.","Ellington A.G.","Faulkner L.","Frankish A.G.","Frankland J.","French L.","Garner P.","Garnett J.","Gilbert J.G.","Gilson C.J.","Ghori J.","Grafham D.V.","Gribble S.M.","Griffiths C.","Hall R.E.","Hammond S.","Harley J.L.","Hart E.A.","Heath P.D.","Howden P.J.","Huckle E.J.","Hunt P.J.","Hunt A.R.","Johnson C.","Johnson D.","Kay M.","Kimberley A.M.","King A.","Laird G.K.","Langford C.J.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Lloyd C.","Loveland J.E.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","McLaren S.J.","McMurray A.","Milne S.","Moore M.J.","Nickerson T.","Palmer S.A.","Pearce A.V.","Peck A.I.","Pelan S.","Phillimore B.","Porter K.M.","Rice C.M.","Searle S.","Sehra H.K.","Shownkeen R.","Skuce C.D.","Smith M.","Steward C.A.","Sycamore N.","Tester J.","Thomas D.W.","Tracey A.","Tromans A.","Tubby B.","Wall M.","Wallis J.M.","West A.P.","Whitehead S.L.","Willey D.L.","Wilming L.","Wray P.W.","Wright M.W.","Young L.","Coulson A.","Durbin R.","Hubbard T.","Sulston J.E.","Beck S.","Bentley D.R.","Rogers J.","Ross M.T."],"citationCrossReferences":[{"database":"PubMed","id":"15057823"},{"database":"DOI","id":"10.1038/nature02379"}],"title":"The DNA sequence and analysis of human chromosome 13.","publicationDate":"2004","journal":"Nature","firstPage":"522","lastPage":"528","volume":"428"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000471242.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000471242.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"17081983","citationType":"journal article","authors":["Olsen J.V.","Blagoev B.","Gnad F.","Macek B.","Kumar C.","Mortensen P.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"17081983"},{"database":"DOI","id":"10.1016/j.cell.2006.09.026"}],"title":"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.","publicationDate":"2006","journal":"Cell","firstPage":"635","lastPage":"648","volume":"127"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"17081983"}]},{"referenceNumber":5,"citation":{"id":"17924679","citationType":"journal article","authors":["Yu L.R.","Zhu Z.","Chan K.C.","Issaq H.J.","Dimitrov D.S.","Veenstra T.D."],"citationCrossReferences":[{"database":"PubMed","id":"17924679"},{"database":"DOI","id":"10.1021/pr070152u"}],"title":"Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.","publicationDate":"2007","journal":"J. Proteome Res.","firstPage":"4150","lastPage":"4162","volume":"6"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"17924679"}]},{"referenceNumber":6,"citation":{"id":"18220336","citationType":"journal article","authors":["Cantin G.T.","Yi W.","Lu B.","Park S.K.","Xu T.","Lee J.D.","Yates J.R."],"citationCrossReferences":[{"database":"PubMed","id":"18220336"},{"database":"DOI","id":"10.1021/pr0705441"}],"title":"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.","publicationDate":"2008","journal":"J. Proteome Res.","firstPage":"1346","lastPage":"1351","volume":"7"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"18220336"}]},{"referenceNumber":7,"citation":{"id":"18669648","citationType":"journal article","authors":["Dephoure N.","Zhou C.","Villen J.","Beausoleil S.A.","Bakalarski C.E.","Elledge S.J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"18669648"},{"database":"DOI","id":"10.1073/pnas.0805139105"}],"title":"A quantitative atlas of mitotic phosphorylation.","publicationDate":"2008","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10762","lastPage":"10767","volume":"105"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"18669648"}]},{"referenceNumber":8,"citation":{"id":"18318008","citationType":"journal article","authors":["Han G.","Ye M.","Zhou H.","Jiang X.","Feng S.","Jiang X.","Tian R.","Wan D.","Zou H.","Gu J."],"citationCrossReferences":[{"database":"PubMed","id":"18318008"},{"database":"DOI","id":"10.1002/pmic.200700884"}],"title":"Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.","publicationDate":"2008","journal":"Proteomics","firstPage":"1346","lastPage":"1361","volume":"8"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"18318008"}]},{"referenceNumber":9,"citation":{"id":"19413330","citationType":"journal article","authors":["Gauci S.","Helbig A.O.","Slijper M.","Krijgsveld J.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"19413330"},{"database":"DOI","id":"10.1021/ac9004309"}],"title":"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.","publicationDate":"2009","journal":"Anal. Chem.","firstPage":"4493","lastPage":"4501","volume":"81"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"19413330"}]},{"referenceNumber":10,"citation":{"id":"20068231","citationType":"journal article","authors":["Olsen J.V.","Vermeulen M.","Santamaria A.","Kumar C.","Miller M.L.","Jensen L.J.","Gnad F.","Cox J.","Jensen T.S.","Nigg E.A.","Brunak S.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"20068231"},{"database":"DOI","id":"10.1126/scisignal.2000475"}],"title":"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.","publicationDate":"2010","journal":"Sci. Signal.","firstPage":"RA3","lastPage":"RA3","volume":"3"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"20068231"}]},{"referenceNumber":11,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Burckstummer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"21269460"}]},{"referenceNumber":12,"citation":{"id":"21406692","citationType":"journal article","authors":["Rigbolt K.T.","Prokhorova T.A.","Akimov V.","Henningsen J.","Johansen P.T.","Kratchmarova I.","Kassem M.","Mann M.","Olsen J.V.","Blagoev B."],"citationCrossReferences":[{"database":"PubMed","id":"21406692"},{"database":"DOI","id":"10.1126/scisignal.2001570"}],"title":"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.","publicationDate":"2011","journal":"Sci. Signal.","firstPage":"RS3","lastPage":"RS3","volume":"4"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"21406692"}]},{"referenceNumber":13,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"23186163"}]},{"referenceNumber":14,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"24275569"}]},{"referenceNumber":15,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000471242.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL136300","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL137249","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL161896","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL445223","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"KF455815","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"NP_001273768.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001286839.2"}]},{"database":"AlphaFoldDB","id":"C9JME2","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"C9JME2","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"10830","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"619","properties":[{"key":"antibodies","value":"214 antibodies from 21 providers"}]},{"database":"DNASU","id":"10160","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000595437.5","properties":[{"key":"ProteinId","value":"ENSP00000471242.1"},{"key":"GeneId","value":"ENSG00000152767.18"}]},{"database":"Ensembl","id":"ENST00000627049.2","properties":[{"key":"ProteinId","value":"ENSP00000486285.1"},{"key":"GeneId","value":"ENSG00000152767.18"}]},{"database":"GeneID","id":"10160","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc001vnh.4","properties":[{"key":"OrganismName","value":"human"}]},{"database":"CTD","id":"10160","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"10160","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:3591","properties":[{"key":"GeneName","value":"FARP1"}]},{"database":"OpenTargets","id":"ENSG00000152767","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000152767","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000155318","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"PHCLTLC","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9990815at2759","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"10160","properties":[{"key":"hits","value":"15 hits in 1145 CRISPR screens"}]},{"database":"ChiTaRS","id":"FARP1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 13"}]},{"database":"Bgee","id":"ENSG00000152767","properties":[{"key":"ExpressionPatterns","value":"Expressed in renal medulla and 204 other cell types or tissues"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0043197","properties":[{"key":"GoTerm","value":"C:dendritic spine"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0030175","properties":[{"key":"GoTerm","value":"C:filopodium"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0008092","properties":[{"key":"GoTerm","value":"F:cytoskeletal protein binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0005085","properties":[{"key":"GoTerm","value":"F:guanyl-nucleotide exchange factor activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd14473","properties":[{"key":"EntryName","value":"FERM_B-lobe"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd13193","properties":[{"key":"EntryName","value":"FERM_C_FARP1-like"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd01220","properties":[{"key":"EntryName","value":"PH1_FARP1-like"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd13235","properties":[{"key":"EntryName","value":"PH2_FARP1-like"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd00160","properties":[{"key":"EntryName","value":"RhoGEF"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.30.29.30:FF:000002","properties":[{"key":"EntryName","value":"Band 4.1-like protein 5 isoform 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.10.20.90:FF:000040","properties":[{"key":"EntryName","value":"FERM, RhoGEF and pleckstrin domain-containing protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.80.10:FF:000005","properties":[{"key":"EntryName","value":"FERM, RhoGEF and pleckstrin domain-containing protein 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.900.10:FF:000021","properties":[{"key":"EntryName","value":"FERM, RhoGEF and pleckstrin domain-containing protein 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.30.29.30:FF:000046","properties":[{"key":"EntryName","value":"FERM, RhoGEF and pleckstrin domain-containing protein 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.80.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.900.10","properties":[{"key":"EntryName","value":"Dbl homology (DH) domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.10.20.90","properties":[{"key":"EntryName","value":"Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.30.29.30","properties":[{"key":"EntryName","value":"Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"},{"key":"MatchStatus","value":"3"}]},{"database":"InterPro","id":"IPR019749","properties":[{"key":"EntryName","value":"Band_41_domain"}]},{"database":"InterPro","id":"IPR035899","properties":[{"key":"EntryName","value":"DBL_dom_sf"}]},{"database":"InterPro","id":"IPR000219","properties":[{"key":"EntryName","value":"DH_dom"}]},{"database":"InterPro","id":"IPR000798","properties":[{"key":"EntryName","value":"Ez/rad/moesin-like"}]},{"database":"InterPro","id":"IPR014847","properties":[{"key":"EntryName","value":"FA"}]},{"database":"InterPro","id":"IPR041788","properties":[{"key":"EntryName","value":"FARP1/FARP2/FRMD7_FERM_C"}]},{"database":"InterPro","id":"IPR014352","properties":[{"key":"EntryName","value":"FERM/acyl-CoA-bd_prot_sf"}]},{"database":"InterPro","id":"IPR035963","properties":[{"key":"EntryName","value":"FERM_2"}]},{"database":"InterPro","id":"IPR019748","properties":[{"key":"EntryName","value":"FERM_central"}]},{"database":"InterPro","id":"IPR019747","properties":[{"key":"EntryName","value":"FERM_CS"}]},{"database":"InterPro","id":"IPR000299","properties":[{"key":"EntryName","value":"FERM_domain"}]},{"database":"InterPro","id":"IPR018979","properties":[{"key":"EntryName","value":"FERM_N"}]},{"database":"InterPro","id":"IPR018980","properties":[{"key":"EntryName","value":"FERM_PH-like_C"}]},{"database":"InterPro","id":"IPR011993","properties":[{"key":"EntryName","value":"PH-like_dom_sf"}]},{"database":"InterPro","id":"IPR001849","properties":[{"key":"EntryName","value":"PH_domain"}]},{"database":"InterPro","id":"IPR051835","properties":[{"key":"EntryName","value":"RAC1-GEF"}]},{"database":"InterPro","id":"IPR029071","properties":[{"key":"EntryName","value":"Ubiquitin-like_domsf"}]},{"database":"PANTHER","id":"PTHR45858","properties":[{"key":"EntryName","value":"FERM DOMAIN CONTAINING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR45858:SF2","properties":[{"key":"EntryName","value":"FERM, ARHGEF AND PLECKSTRIN DOMAIN-CONTAINING PROTEIN 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08736","properties":[{"key":"EntryName","value":"FA"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF09380","properties":[{"key":"EntryName","value":"FERM_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00373","properties":[{"key":"EntryName","value":"FERM_M"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF09379","properties":[{"key":"EntryName","value":"FERM_N"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00169","properties":[{"key":"EntryName","value":"PH"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF00621","properties":[{"key":"EntryName","value":"RhoGEF"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00935","properties":[{"key":"EntryName","value":"BAND41"}]},{"database":"PRINTS","id":"PR00661","properties":[{"key":"EntryName","value":"ERMFAMILY"}]},{"database":"SMART","id":"SM00295","properties":[{"key":"EntryName","value":"B41"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM01195","properties":[{"key":"EntryName","value":"FA"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM01196","properties":[{"key":"EntryName","value":"FERM_C"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00233","properties":[{"key":"EntryName","value":"PH"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00325","properties":[{"key":"EntryName","value":"RhoGEF"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48065","properties":[{"key":"EntryName","value":"DBL homology domain (DH-domain)"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF50729","properties":[{"key":"EntryName","value":"PH domain-like"},{"key":"MatchStatus","value":"3"}]},{"database":"SUPFAM","id":"SSF47031","properties":[{"key":"EntryName","value":"Second domain of FERM"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54236","properties":[{"key":"EntryName","value":"Ubiquitin-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50010","properties":[{"key":"EntryName","value":"DH_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00660","properties":[{"key":"EntryName","value":"FERM_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50057","properties":[{"key":"EntryName","value":"FERM_3"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50003","properties":[{"key":"EntryName","value":"PH_DOMAIN"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPQRAPGKVLLDAVCNHLNLVEGDYFGLEFPDHKKITVWLDLLKPIVKQIRRPKHVVVKFVVKFFPPDHTQLQEELTRYLFALQVKQDLAQGRLTCNDTSAALLISHIVQSEIGDFDEALDREHLAKNKYIPQQDALEDKIVEFHHNHIGQTPAESDFQLLEIARRLEMYGIRLHPAKDREGTKINLAVANTGILVFQGFTKINAFNWAKVRKLSFKRKRFLIKLRPDANSAYQDTLEFLMASRDFCKSFWKICVEHHAFFRLFEEPKPKPKPVLFSRGSSFRFSGRTQKQVLDYVKEGGHKKVQFERKHSKIHSIRSLASQPTELNSEVLEQSQQSTSLTFGEGAESPGGQSCRRGKEPKVSAGEPGSHPSPAPRRSPAGNKQADGAASAPTEEEEEVVKDRTQQSKPQPPQPSTGSLTGSPHLSELSVNSQGGVAPANVTLSPNLSPDTKQASPLISPLLNDQACPRTDDEDEGRRKRFPTDKAYFIAKEVSTTERTYLKDLEVITSWFQSTVSKEDAMPEALKSLIFPNFEPLHKFHTNFLKEIEQRLALWEGRSNAQIRDYQRIGDVMLKNIQGMKHLAAHLWKHSEALEALENGIKSSRRLENFCRDFELQKVCYLPLNTFLLRPLHRLMHYKQVLERLCKHHPPSHADFRDCRAALAEITEMVAQLHGTMIKMENFQKLHELKKDLIGIDNLVVPGRPGSFSLIRTPHLGQARRIPCAPERRPLLLVKEFIRLGSLSKLSGKGLQQRMFFLFNDVLLYTSRGLTASNQFKVHGQLPLYGMTIEESEDEWGVPHCLTLRGQRQSIIVAASSRSEMEKWVEDIQMAIDLAEKSSSPAPEFLASSPPDNKSPDEATAADQESEDDLSASRTSLERQAPHRGNTMVHVCWHRNTSVSMVDFSIAVENQLSGNLLRKFKNSNGWQKLWVVFTNFCLFFYKSHQDNHPLASLPLLGYSLTIPSESENIQKDYVFKLHFKSHVYYFRAESEYTFERWMEVIRSATSSASRPHVLSHKESLVY","length":1076,"molWeight":122095,"crc64":"34B31A3B5AA0A043","md5":"20229B266A49D654A8EBE5C34BEBD9AB"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Domain":4,"Region":3,"Compositional bias":3},"uniParcId":"UPI000041C6E3"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A1B0GV68","uniProtkbId":"A0A1B0GV68_HUMAN","entryAudit":{"firstPublicDate":"2016-10-05","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2016-10-05","entryVersion":58,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000490391.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000490391.1"}],"value":"FERM, ARH/RhoGEF and pleckstrin domain protein 1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000490391.1"}],"value":"FARP1"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004552"}],"value":"Cell projection, dendritic spine","id":"SL-0284"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004496"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004370"}],"value":"Membrane","id":"SL-0162"}}]}],"features":[{"type":"Domain","location":{"start":{"value":40,"modifier":"EXACT"},"end":{"value":320,"modifier":"EXACT"}},"description":"FERM","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50057"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":37,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":369,"modifier":"EXACT"},"end":{"value":671,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":686,"modifier":"EXACT"},"end":{"value":719,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":737,"modifier":"EXACT"},"end":{"value":770,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":373,"modifier":"EXACT"},"end":{"value":396,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":533,"modifier":"EXACT"},"end":{"value":543,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":596,"modifier":"EXACT"},"end":{"value":611,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":612,"modifier":"EXACT"},"end":{"value":624,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":743,"modifier":"EXACT"},"end":{"value":753,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023273"}],"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022658"}],"id":"KW-0344","category":"Molecular function","name":"Guanine-nucleotide releasing factor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0A1B0GV68"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0A1B0GV68"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023018"}],"id":"KW-0770","category":"Cellular component","name":"Synapse"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000490391.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15057823","citationType":"journal article","authors":["Dunham A.","Matthews L.H.","Burton J.","Ashurst J.L.","Howe K.L.","Ashcroft K.J.","Beare D.M.","Burford D.C.","Hunt S.E.","Griffiths-Jones S.","Jones M.C.","Keenan S.J.","Oliver K.","Scott C.E.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Andrews D.T.","Ashwell R.I.","Babbage A.K.","Bagguley C.L.","Bailey J.","Bannerjee R.","Barlow K.F.","Bates K.","Beasley H.","Bird C.P.","Bray-Allen S.","Brown A.J.","Brown J.Y.","Burrill W.","Carder C.","Carter N.P.","Chapman J.C.","Clamp M.E.","Clark S.Y.","Clarke G.","Clee C.M.","Clegg S.C.","Cobley V.","Collins J.E.","Corby N.","Coville G.J.","Deloukas P.","Dhami P.","Dunham I.","Dunn M.","Earthrowl M.E.","Ellington A.G.","Faulkner L.","Frankish A.G.","Frankland J.","French L.","Garner P.","Garnett J.","Gilbert J.G.","Gilson C.J.","Ghori J.","Grafham D.V.","Gribble S.M.","Griffiths C.","Hall R.E.","Hammond S.","Harley J.L.","Hart E.A.","Heath P.D.","Howden P.J.","Huckle E.J.","Hunt P.J.","Hunt A.R.","Johnson C.","Johnson D.","Kay M.","Kimberley A.M.","King A.","Laird G.K.","Langford C.J.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Lloyd C.","Loveland J.E.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","McLaren S.J.","McMurray A.","Milne S.","Moore M.J.","Nickerson T.","Palmer S.A.","Pearce A.V.","Peck A.I.","Pelan S.","Phillimore B.","Porter K.M.","Rice C.M.","Searle S.","Sehra H.K.","Shownkeen R.","Skuce C.D.","Smith M.","Steward C.A.","Sycamore N.","Tester J.","Thomas D.W.","Tracey A.","Tromans A.","Tubby B.","Wall M.","Wallis J.M.","West A.P.","Whitehead S.L.","Willey D.L.","Wilming L.","Wray P.W.","Wright M.W.","Young L.","Coulson A.","Durbin R.","Hubbard T.","Sulston J.E.","Beck S.","Bentley D.R.","Rogers J.","Ross M.T."],"citationCrossReferences":[{"database":"PubMed","id":"15057823"},{"database":"DOI","id":"10.1038/nature02379"}],"title":"The DNA sequence and analysis of human chromosome 13.","publicationDate":"2004","journal":"Nature","firstPage":"522","lastPage":"528","volume":"428"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000490391.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000490391.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"17081983","citationType":"journal article","authors":["Olsen J.V.","Blagoev B.","Gnad F.","Macek B.","Kumar C.","Mortensen P.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"17081983"},{"database":"DOI","id":"10.1016/j.cell.2006.09.026"}],"title":"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.","publicationDate":"2006","journal":"Cell","firstPage":"635","lastPage":"648","volume":"127"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"17081983"}]},{"referenceNumber":5,"citation":{"id":"17924679","citationType":"journal article","authors":["Yu L.R.","Zhu Z.","Chan K.C.","Issaq H.J.","Dimitrov D.S.","Veenstra T.D."],"citationCrossReferences":[{"database":"PubMed","id":"17924679"},{"database":"DOI","id":"10.1021/pr070152u"}],"title":"Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.","publicationDate":"2007","journal":"J. Proteome Res.","firstPage":"4150","lastPage":"4162","volume":"6"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"17924679"}]},{"referenceNumber":6,"citation":{"id":"18220336","citationType":"journal article","authors":["Cantin G.T.","Yi W.","Lu B.","Park S.K.","Xu T.","Lee J.D.","Yates J.R."],"citationCrossReferences":[{"database":"PubMed","id":"18220336"},{"database":"DOI","id":"10.1021/pr0705441"}],"title":"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.","publicationDate":"2008","journal":"J. Proteome Res.","firstPage":"1346","lastPage":"1351","volume":"7"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"18220336"}]},{"referenceNumber":7,"citation":{"id":"18669648","citationType":"journal article","authors":["Dephoure N.","Zhou C.","Villen J.","Beausoleil S.A.","Bakalarski C.E.","Elledge S.J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"18669648"},{"database":"DOI","id":"10.1073/pnas.0805139105"}],"title":"A quantitative atlas of mitotic phosphorylation.","publicationDate":"2008","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10762","lastPage":"10767","volume":"105"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"18669648"}]},{"referenceNumber":8,"citation":{"id":"19413330","citationType":"journal article","authors":["Gauci S.","Helbig A.O.","Slijper M.","Krijgsveld J.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"19413330"},{"database":"DOI","id":"10.1021/ac9004309"}],"title":"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.","publicationDate":"2009","journal":"Anal. Chem.","firstPage":"4493","lastPage":"4501","volume":"81"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"19413330"}]},{"referenceNumber":9,"citation":{"id":"20068231","citationType":"journal article","authors":["Olsen J.V.","Vermeulen M.","Santamaria A.","Kumar C.","Miller M.L.","Jensen L.J.","Gnad F.","Cox J.","Jensen T.S.","Nigg E.A.","Brunak S.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"20068231"},{"database":"DOI","id":"10.1126/scisignal.2000475"}],"title":"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.","publicationDate":"2010","journal":"Sci. Signal.","firstPage":"RA3","lastPage":"RA3","volume":"3"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"20068231"}]},{"referenceNumber":10,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Burckstummer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"21269460"}]},{"referenceNumber":11,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"23186163"}]},{"referenceNumber":12,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"24275569"}]},{"referenceNumber":13,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000490391.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL136300","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL137249","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL161896","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL445223","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"KF455815","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A1B0GV68","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0A1B0GV68","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"A0A1B0GV68","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"619","properties":[{"key":"antibodies","value":"214 antibodies from 21 providers"}]},{"database":"Ensembl","id":"ENST00000596580.2","properties":[{"key":"ProteinId","value":"ENSP00000490391.1"},{"key":"GeneId","value":"ENSG00000152767.18"}]},{"database":"HGNC","id":"HGNC:3591","properties":[{"key":"GeneName","value":"FARP1"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000152767","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000155318","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"9990815at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"FARP1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 13"}]},{"database":"Bgee","id":"ENSG00000152767","properties":[{"key":"ExpressionPatterns","value":"Expressed in renal medulla and 204 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"A0A1B0GV68","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0043197","properties":[{"key":"GoTerm","value":"C:dendritic spine"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0008092","properties":[{"key":"GoTerm","value":"F:cytoskeletal protein binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd14473","properties":[{"key":"EntryName","value":"FERM_B-lobe"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd13193","properties":[{"key":"EntryName","value":"FERM_C_FARP1-like"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd17189","properties":[{"key":"EntryName","value":"FERM_F1_FARP1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.30.29.30:FF:000002","properties":[{"key":"EntryName","value":"Band 4.1-like protein 5 isoform 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.10.20.90:FF:000040","properties":[{"key":"EntryName","value":"FERM, RhoGEF and pleckstrin domain-containing protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.80.10:FF:000005","properties":[{"key":"EntryName","value":"FERM, RhoGEF and pleckstrin domain-containing protein 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.80.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.10.20.90","properties":[{"key":"EntryName","value":"Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.30.29.30","properties":[{"key":"EntryName","value":"Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR019749","properties":[{"key":"EntryName","value":"Band_41_domain"}]},{"database":"InterPro","id":"IPR000798","properties":[{"key":"EntryName","value":"Ez/rad/moesin-like"}]},{"database":"InterPro","id":"IPR014847","properties":[{"key":"EntryName","value":"FA"}]},{"database":"InterPro","id":"IPR041788","properties":[{"key":"EntryName","value":"FARP1/FARP2/FRMD7_FERM_C"}]},{"database":"InterPro","id":"IPR014352","properties":[{"key":"EntryName","value":"FERM/acyl-CoA-bd_prot_sf"}]},{"database":"InterPro","id":"IPR035963","properties":[{"key":"EntryName","value":"FERM_2"}]},{"database":"InterPro","id":"IPR019748","properties":[{"key":"EntryName","value":"FERM_central"}]},{"database":"InterPro","id":"IPR019747","properties":[{"key":"EntryName","value":"FERM_CS"}]},{"database":"InterPro","id":"IPR000299","properties":[{"key":"EntryName","value":"FERM_domain"}]},{"database":"InterPro","id":"IPR018979","properties":[{"key":"EntryName","value":"FERM_N"}]},{"database":"InterPro","id":"IPR018980","properties":[{"key":"EntryName","value":"FERM_PH-like_C"}]},{"database":"InterPro","id":"IPR011993","properties":[{"key":"EntryName","value":"PH-like_dom_sf"}]},{"database":"InterPro","id":"IPR051835","properties":[{"key":"EntryName","value":"RAC1-GEF"}]},{"database":"InterPro","id":"IPR029071","properties":[{"key":"EntryName","value":"Ubiquitin-like_domsf"}]},{"database":"PANTHER","id":"PTHR45858","properties":[{"key":"EntryName","value":"FERM DOMAIN CONTAINING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR45858:SF2","properties":[{"key":"EntryName","value":"FERM, ARHGEF AND PLECKSTRIN DOMAIN-CONTAINING PROTEIN 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08736","properties":[{"key":"EntryName","value":"FA"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF09380","properties":[{"key":"EntryName","value":"FERM_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00373","properties":[{"key":"EntryName","value":"FERM_M"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF09379","properties":[{"key":"EntryName","value":"FERM_N"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00935","properties":[{"key":"EntryName","value":"BAND41"}]},{"database":"PRINTS","id":"PR00661","properties":[{"key":"EntryName","value":"ERMFAMILY"}]},{"database":"SMART","id":"SM00295","properties":[{"key":"EntryName","value":"B41"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM01195","properties":[{"key":"EntryName","value":"FA"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM01196","properties":[{"key":"EntryName","value":"FERM_C"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF50729","properties":[{"key":"EntryName","value":"PH domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF47031","properties":[{"key":"EntryName","value":"Second domain of FERM"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54236","properties":[{"key":"EntryName","value":"Ubiquitin-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00660","properties":[{"key":"EntryName","value":"FERM_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50057","properties":[{"key":"EntryName","value":"FERM_3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPQRAPGKVLLDAVCNHLNLVEGDYFGLEFPDHKKITVWLDLLKPIVKQIRRPKHVVVKFVVKFFPPDHTQLQEELTRYLFALQVKQDLAQGRLTCNDTSAALLISHIVQSEIGDFDEALDREHLAKNKYIPQQDALEDKIVEFHHNHIGQTPAESDFQLLEIARRLEMYGIRLHPAKDREGTKINLAVANTGILVFQGFTKINAFNWAKVRKLSFKRKRFLIKLRPDANSAYQDTLEFLMASRDFCKSFWKICVEHHAFFRLFEEPKPKPKPVLFSRGSSFRFSGRTQKQVLDYVKEGGHKKVQFERKHSKIHSIRSLASQPTELNSEVLEQSQQSTSLTFGEGAESPGGQSCRRGKEPKVSAGEPGSHPSPAPRRSPAGNKQADGAASAPTEEEEEVVKDRTQQSKPQPPQPSTGPASRAARGSSTSIPFIDCSDVDSEYDLLREQASRSRSRSRSRSQTNDNYEGDLTSGVYLLSREEGRREAGRRASPHSAKSSRPPSGEFLDDDSADITFDMSGSPRLPRHSSLIDEMFKGSAGHSPLATPLSPSSSSSSPNMSWDRTGSQGYVSENGHDHREGSMGEDTLPDQGPPYERWSPTSPRPYMRNLPGRCNKSETDPLILSQVAFTPEAMDGLGGRGKWGQASAAAPEGRSLANGTPPMGAASKVPAVQSVCARGMAGQLAPLQVTEGSTSSGTESSESDSEMLIPGSQPLIFGNPAVLRSPSLLRSRGSLGGLRLSEEQEEDE","length":801,"molWeight":88101,"crc64":"5F69A1329C60FAD6","md5":"C9A27E23EB51FA4E0FC835B628CF5C66"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Domain":1,"Region":4,"Compositional bias":5},"uniParcId":"UPI0007E52CF0"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8PNS4","uniProtkbId":"A0ACI8PNS4_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000541564.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00040395"}],"value":"FERM, ARHGEF and pleckstrin domain-containing protein 1"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00042170"}],"value":"FERM, RhoGEF and pleckstrin domain-containing protein 1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000541564.1"}],"value":"FARP1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00054998"}],"value":"Functions as a guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00064538"}],"value":"Interacts with CADM1. Interacts with RAC1"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004413"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004413"}],"value":"Peripheral membrane protein","id":"SL-9903"},"orientation":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004413"}],"value":"Cytoplasmic side","id":"SL-9910"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004279"}],"value":"Cell projection, dendrite","id":"SL-0283"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004552"}],"value":"Cell projection, dendritic spine","id":"SL-0284"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004486"}],"value":"Cell projection, filopodium","id":"SL-0286"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004514"}],"value":"Cytoplasm, cytosol","id":"SL-0091"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00034102"}],"value":"Synapse, synaptosome","id":"SL-0261"}}]}],"features":[{"type":"Domain","location":{"start":{"value":40,"modifier":"EXACT"},"end":{"value":320,"modifier":"EXACT"}},"description":"FERM","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50057"}]},{"type":"Domain","location":{"start":{"value":540,"modifier":"EXACT"},"end":{"value":730,"modifier":"EXACT"}},"description":"DH","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50010"}]},{"type":"Domain","location":{"start":{"value":759,"modifier":"EXACT"},"end":{"value":856,"modifier":"EXACT"}},"description":"PH","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50003"}]},{"type":"Domain","location":{"start":{"value":967,"modifier":"EXACT"},"end":{"value":1064,"modifier":"EXACT"}},"description":"PH","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50003"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":37,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":361,"modifier":"EXACT"},"end":{"value":534,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":911,"modifier":"EXACT"},"end":{"value":938,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":373,"modifier":"EXACT"},"end":{"value":396,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":471,"modifier":"EXACT"},"end":{"value":489,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":496,"modifier":"EXACT"},"end":{"value":511,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023273"}],"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022473"}],"id":"KW-0217","category":"Molecular function","name":"Developmental protein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022658"}],"id":"KW-0344","category":"Molecular function","name":"Guanine-nucleotide releasing factor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8PNS4"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8PNS4"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023018"}],"id":"KW-0770","category":"Cellular component","name":"Synapse"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022599"}],"id":"KW-0771","category":"Cellular component","name":"Synaptosome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000541564.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15057823","citationType":"journal article","authors":["Dunham A.","Matthews L.H.","Burton J.","Ashurst J.L.","Howe K.L.","Ashcroft K.J.","Beare D.M.","Burford D.C.","Hunt S.E.","Griffiths-Jones S.","Jones M.C.","Keenan S.J.","Oliver K.","Scott C.E.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Andrews D.T.","Ashwell R.I.","Babbage A.K.","Bagguley C.L.","Bailey J.","Bannerjee R.","Barlow K.F.","Bates K.","Beasley H.","Bird C.P.","Bray-Allen S.","Brown A.J.","Brown J.Y.","Burrill W.","Carder C.","Carter N.P.","Chapman J.C.","Clamp M.E.","Clark S.Y.","Clarke G.","Clee C.M.","Clegg S.C.","Cobley V.","Collins J.E.","Corby N.","Coville G.J.","Deloukas P.","Dhami P.","Dunham I.","Dunn M.","Earthrowl M.E.","Ellington A.G.","Faulkner L.","Frankish A.G.","Frankland J.","French L.","Garner P.","Garnett J.","Gilbert J.G.","Gilson C.J.","Ghori J.","Grafham D.V.","Gribble S.M.","Griffiths C.","Hall R.E.","Hammond S.","Harley J.L.","Hart E.A.","Heath P.D.","Howden P.J.","Huckle E.J.","Hunt P.J.","Hunt A.R.","Johnson C.","Johnson D.","Kay M.","Kimberley A.M.","King A.","Laird G.K.","Langford C.J.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Lloyd C.","Loveland J.E.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","McLaren S.J.","McMurray A.","Milne S.","Moore M.J.","Nickerson T.","Palmer S.A.","Pearce A.V.","Peck A.I.","Pelan S.","Phillimore B.","Porter K.M.","Rice C.M.","Searle S.","Sehra H.K.","Shownkeen R.","Skuce C.D.","Smith M.","Steward C.A.","Sycamore N.","Tester J.","Thomas D.W.","Tracey A.","Tromans A.","Tubby B.","Wall M.","Wallis J.M.","West A.P.","Whitehead S.L.","Willey D.L.","Wilming L.","Wray P.W.","Wright M.W.","Young L.","Coulson A.","Durbin R.","Hubbard T.","Sulston J.E.","Beck S.","Bentley D.R.","Rogers J.","Ross M.T."],"citationCrossReferences":[{"database":"PubMed","id":"15057823"},{"database":"DOI","id":"10.1038/nature02379"}],"title":"The DNA sequence and analysis of human chromosome 13.","publicationDate":"2004","journal":"Nature","firstPage":"522","lastPage":"528","volume":"428"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000541564.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000541564.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000541564.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL136300","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL137249","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL161896","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL445223","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"KF455815","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000871505.1","properties":[{"key":"ProteinId","value":"ENSP00000541564.1"},{"key":"GeneId","value":"ENSG00000152767.18"}]},{"database":"HGNC","id":"HGNC:3591","properties":[{"key":"GeneName","value":"FARP1"}]},{"database":"OpenTargets","id":"ENSG00000152767","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000155318","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 13"}]},{"database":"CDD","id":"cd14473","properties":[{"key":"EntryName","value":"FERM_B-lobe"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd13193","properties":[{"key":"EntryName","value":"FERM_C_FARP1-like"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd01220","properties":[{"key":"EntryName","value":"PH1_FARP1-like"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd13235","properties":[{"key":"EntryName","value":"PH2_FARP1-like"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd00160","properties":[{"key":"EntryName","value":"RhoGEF"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.30.29.30:FF:000002","properties":[{"key":"EntryName","value":"Band 4.1-like protein 5 isoform 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.10.20.90:FF:000040","properties":[{"key":"EntryName","value":"FERM, RhoGEF and pleckstrin domain-containing protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.80.10:FF:000005","properties":[{"key":"EntryName","value":"FERM, RhoGEF and pleckstrin domain-containing protein 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.900.10:FF:000021","properties":[{"key":"EntryName","value":"FERM, RhoGEF and pleckstrin domain-containing protein 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.30.29.30:FF:000046","properties":[{"key":"EntryName","value":"FERM, RhoGEF and pleckstrin domain-containing protein 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.80.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.900.10","properties":[{"key":"EntryName","value":"Dbl homology (DH) domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.10.20.90","properties":[{"key":"EntryName","value":"Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.30.29.30","properties":[{"key":"EntryName","value":"Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"},{"key":"MatchStatus","value":"3"}]},{"database":"InterPro","id":"IPR019749","properties":[{"key":"EntryName","value":"Band_41_domain"}]},{"database":"InterPro","id":"IPR035899","properties":[{"key":"EntryName","value":"DBL_dom_sf"}]},{"database":"InterPro","id":"IPR000219","properties":[{"key":"EntryName","value":"DH_dom"}]},{"database":"InterPro","id":"IPR000798","properties":[{"key":"EntryName","value":"Ez/rad/moesin-like"}]},{"database":"InterPro","id":"IPR014847","properties":[{"key":"EntryName","value":"FA"}]},{"database":"InterPro","id":"IPR041788","properties":[{"key":"EntryName","value":"FARP1/FARP2/FRMD7_FERM_C"}]},{"database":"InterPro","id":"IPR014352","properties":[{"key":"EntryName","value":"FERM/acyl-CoA-bd_prot_sf"}]},{"database":"InterPro","id":"IPR035963","properties":[{"key":"EntryName","value":"FERM_2"}]},{"database":"InterPro","id":"IPR019748","properties":[{"key":"EntryName","value":"FERM_central"}]},{"database":"InterPro","id":"IPR019747","properties":[{"key":"EntryName","value":"FERM_CS"}]},{"database":"InterPro","id":"IPR000299","properties":[{"key":"EntryName","value":"FERM_domain"}]},{"database":"InterPro","id":"IPR018979","properties":[{"key":"EntryName","value":"FERM_N"}]},{"database":"InterPro","id":"IPR018980","properties":[{"key":"EntryName","value":"FERM_PH-like_C"}]},{"database":"InterPro","id":"IPR011993","properties":[{"key":"EntryName","value":"PH-like_dom_sf"}]},{"database":"InterPro","id":"IPR001849","properties":[{"key":"EntryName","value":"PH_domain"}]},{"database":"InterPro","id":"IPR051835","properties":[{"key":"EntryName","value":"RAC1-GEF"}]},{"database":"InterPro","id":"IPR029071","properties":[{"key":"EntryName","value":"Ubiquitin-like_domsf"}]},{"database":"PANTHER","id":"PTHR45858","properties":[{"key":"EntryName","value":"FERM DOMAIN CONTAINING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR45858:SF2","properties":[{"key":"EntryName","value":"FERM, ARHGEF AND PLECKSTRIN DOMAIN-CONTAINING PROTEIN 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08736","properties":[{"key":"EntryName","value":"FA"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF09380","properties":[{"key":"EntryName","value":"FERM_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00373","properties":[{"key":"EntryName","value":"FERM_M"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF09379","properties":[{"key":"EntryName","value":"FERM_N"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00169","properties":[{"key":"EntryName","value":"PH"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF00621","properties":[{"key":"EntryName","value":"RhoGEF"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00935","properties":[{"key":"EntryName","value":"BAND41"}]},{"database":"PRINTS","id":"PR00661","properties":[{"key":"EntryName","value":"ERMFAMILY"}]},{"database":"SMART","id":"SM00295","properties":[{"key":"EntryName","value":"B41"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM01195","properties":[{"key":"EntryName","value":"FA"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM01196","properties":[{"key":"EntryName","value":"FERM_C"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00233","properties":[{"key":"EntryName","value":"PH"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00325","properties":[{"key":"EntryName","value":"RhoGEF"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48065","properties":[{"key":"EntryName","value":"DBL homology domain (DH-domain)"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF50729","properties":[{"key":"EntryName","value":"PH domain-like"},{"key":"MatchStatus","value":"3"}]},{"database":"SUPFAM","id":"SSF47031","properties":[{"key":"EntryName","value":"Second domain of FERM"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54236","properties":[{"key":"EntryName","value":"Ubiquitin-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50010","properties":[{"key":"EntryName","value":"DH_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00660","properties":[{"key":"EntryName","value":"FERM_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50057","properties":[{"key":"EntryName","value":"FERM_3"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50003","properties":[{"key":"EntryName","value":"PH_DOMAIN"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPQRAPGKVLLDAVCNHLNLVEGDYFGLEFPDHKKITVWLDLLKPIVKQIRRPKHVVVKFVVKFFPPDHTQLQEELTRYLFALQVKQDLAQGRLTCNDTSAALLISHIVQSEIGDFDEALDREHLAKNKYIPQQDALEDKIVEFHHNHIGQTPAESDFQLLEIARRLEMYGIRLHPAKDREGTKINLAVANTGILVFQGFTKINAFNWAKVRKLSFKRKRFLIKLRPDANSAYQDTLEFLMASRDFCKSFWKICVEHHAFFRLFEEPKPKPKPVLFSRGSSFRFSGRTQKQVLDYVKEGGHKKVQFERKHSKIHSIRSLASQPTELNSEVLEQSQQSTSLTFGEGAESPGGQSCRRGKEPKVSAGEPGSHPSPAPRRSPAGNKQADGAASAPTEEEEEVVKDRTQQSKPQPPQPSTGSLTGSPHLSELSVNSQGGVAPANVTLSPNLSPDTKQASPLISPLLNDQACPRTDDEDEGRRKRFPTDKAYFIAKEVSTTERTYLKDLEVITSWFQSTVSKEDAMPEALKSLIFPNFEPLHKFHTNFLKEIEQRLALWEGRSNAQIRDYQRIGDVMLKNIQGMKHLAAHLWKHSEALEALENGIKSSRRLENFCRDFELQKVCYLPLNTFLLRPLHRLMHYKQVLERLCKHHPPSHADFRDCRAALAEITEMVAQLHGTMIKMENFQKLHELKKDLIGIDNLVVPGREFIRLGSLSKLSGKGLQQRMFFLFNDVLLYTSRGLTASNQFKVHGQLPLYGMTIEESEDEWGVPHCLTLRGQRQSIIVAASSRSEMEKWVEDIQMAIDLAEKSSSPAPEFLASSPPDNSCDCCEPPNLPAPQSVSGRGAGRKDQKCCLLPHPVESPDEATAADQESEDDLSASRTSLERQAPHRGNTMVHVCWHRNTSVSMVDFSIAVENQLSGNLLRKFKNSNGWQKLWVVFTNFCLFFYKSHQDNHPLASLPLLGYSLTIPSESENIQKDYVFKLHFKSHVYYFRAESEYTFERWMEVIRSATSSASRPHVLSHKESLVY","length":1080,"molWeight":122280,"crc64":"32D497AB5BE23AF8","md5":"4F490B23D147BFF5E37B94C3C79F7AB6"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Domain":4,"Region":3,"Compositional bias":3},"uniParcId":"UPI004031E10D"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8T4H3","uniProtkbId":"A0ACI8T4H3_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000592639.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00040395"}],"value":"FERM, ARHGEF and pleckstrin domain-containing protein 1"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00042170"}],"value":"FERM, RhoGEF and pleckstrin domain-containing protein 1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000592639.1"}],"value":"FARP1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00054998"}],"value":"Functions as a guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00064538"}],"value":"Interacts with CADM1. Interacts with RAC1"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004413"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004413"}],"value":"Peripheral membrane protein","id":"SL-9903"},"orientation":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004413"}],"value":"Cytoplasmic side","id":"SL-9910"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004279"}],"value":"Cell projection, dendrite","id":"SL-0283"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004552"}],"value":"Cell projection, dendritic spine","id":"SL-0284"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004486"}],"value":"Cell projection, filopodium","id":"SL-0286"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004514"}],"value":"Cytoplasm, cytosol","id":"SL-0091"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00034102"}],"value":"Synapse, synaptosome","id":"SL-0261"}}]}],"features":[{"type":"Domain","location":{"start":{"value":40,"modifier":"EXACT"},"end":{"value":320,"modifier":"EXACT"}},"description":"FERM","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50057"}]},{"type":"Domain","location":{"start":{"value":540,"modifier":"EXACT"},"end":{"value":739,"modifier":"EXACT"}},"description":"DH","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50010"}]},{"type":"Domain","location":{"start":{"value":768,"modifier":"EXACT"},"end":{"value":865,"modifier":"EXACT"}},"description":"PH","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50003"}]},{"type":"Domain","location":{"start":{"value":941,"modifier":"EXACT"},"end":{"value":1038,"modifier":"EXACT"}},"description":"PH","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50003"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":37,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":361,"modifier":"EXACT"},"end":{"value":534,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":873,"modifier":"EXACT"},"end":{"value":912,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":373,"modifier":"EXACT"},"end":{"value":396,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":471,"modifier":"EXACT"},"end":{"value":489,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":496,"modifier":"EXACT"},"end":{"value":511,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023273"}],"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022473"}],"id":"KW-0217","category":"Molecular function","name":"Developmental protein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022658"}],"id":"KW-0344","category":"Molecular function","name":"Guanine-nucleotide releasing factor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8T4H3"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8T4H3"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023018"}],"id":"KW-0770","category":"Cellular component","name":"Synapse"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022599"}],"id":"KW-0771","category":"Cellular component","name":"Synaptosome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000592639.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15057823","citationType":"journal article","authors":["Dunham A.","Matthews L.H.","Burton J.","Ashurst J.L.","Howe K.L.","Ashcroft K.J.","Beare D.M.","Burford D.C.","Hunt S.E.","Griffiths-Jones S.","Jones M.C.","Keenan S.J.","Oliver K.","Scott C.E.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Andrews D.T.","Ashwell R.I.","Babbage A.K.","Bagguley C.L.","Bailey J.","Bannerjee R.","Barlow K.F.","Bates K.","Beasley H.","Bird C.P.","Bray-Allen S.","Brown A.J.","Brown J.Y.","Burrill W.","Carder C.","Carter N.P.","Chapman J.C.","Clamp M.E.","Clark S.Y.","Clarke G.","Clee C.M.","Clegg S.C.","Cobley V.","Collins J.E.","Corby N.","Coville G.J.","Deloukas P.","Dhami P.","Dunham I.","Dunn M.","Earthrowl M.E.","Ellington A.G.","Faulkner L.","Frankish A.G.","Frankland J.","French L.","Garner P.","Garnett J.","Gilbert J.G.","Gilson C.J.","Ghori J.","Grafham D.V.","Gribble S.M.","Griffiths C.","Hall R.E.","Hammond S.","Harley J.L.","Hart E.A.","Heath P.D.","Howden P.J.","Huckle E.J.","Hunt P.J.","Hunt A.R.","Johnson C.","Johnson D.","Kay M.","Kimberley A.M.","King A.","Laird G.K.","Langford C.J.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Lloyd C.","Loveland J.E.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","McLaren S.J.","McMurray A.","Milne S.","Moore M.J.","Nickerson T.","Palmer S.A.","Pearce A.V.","Peck A.I.","Pelan S.","Phillimore B.","Porter K.M.","Rice C.M.","Searle S.","Sehra H.K.","Shownkeen R.","Skuce C.D.","Smith M.","Steward C.A.","Sycamore N.","Tester J.","Thomas D.W.","Tracey A.","Tromans A.","Tubby B.","Wall M.","Wallis J.M.","West A.P.","Whitehead S.L.","Willey D.L.","Wilming L.","Wray P.W.","Wright M.W.","Young L.","Coulson A.","Durbin R.","Hubbard T.","Sulston J.E.","Beck S.","Bentley D.R.","Rogers J.","Ross M.T."],"citationCrossReferences":[{"database":"PubMed","id":"15057823"},{"database":"DOI","id":"10.1038/nature02379"}],"title":"The DNA sequence and analysis of human chromosome 13.","publicationDate":"2004","journal":"Nature","firstPage":"522","lastPage":"528","volume":"428"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000592639.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000592639.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000592639.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL136300","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL137249","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL161896","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL445223","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"KF455815","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000922580.1","properties":[{"key":"ProteinId","value":"ENSP00000592639.1"},{"key":"GeneId","value":"ENSG00000152767.18"}]},{"database":"Ensembl","id":"ENST00000922581.1","properties":[{"key":"ProteinId","value":"ENSP00000592640.1"},{"key":"GeneId","value":"ENSG00000152767.18"}]},{"database":"HGNC","id":"HGNC:3591","properties":[{"key":"GeneName","value":"FARP1"}]},{"database":"OpenTargets","id":"ENSG00000152767","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000155318","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 13"}]},{"database":"CDD","id":"cd14473","properties":[{"key":"EntryName","value":"FERM_B-lobe"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd13193","properties":[{"key":"EntryName","value":"FERM_C_FARP1-like"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd01220","properties":[{"key":"EntryName","value":"PH1_FARP1-like"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd13235","properties":[{"key":"EntryName","value":"PH2_FARP1-like"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd00160","properties":[{"key":"EntryName","value":"RhoGEF"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.30.29.30:FF:000002","properties":[{"key":"EntryName","value":"Band 4.1-like protein 5 isoform 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.10.20.90:FF:000040","properties":[{"key":"EntryName","value":"FERM, RhoGEF and pleckstrin domain-containing protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.80.10:FF:000005","properties":[{"key":"EntryName","value":"FERM, RhoGEF and pleckstrin domain-containing protein 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.900.10:FF:000021","properties":[{"key":"EntryName","value":"FERM, RhoGEF and pleckstrin domain-containing protein 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.30.29.30:FF:000046","properties":[{"key":"EntryName","value":"FERM, RhoGEF and pleckstrin domain-containing protein 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.80.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.900.10","properties":[{"key":"EntryName","value":"Dbl homology (DH) domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.10.20.90","properties":[{"key":"EntryName","value":"Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.30.29.30","properties":[{"key":"EntryName","value":"Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"},{"key":"MatchStatus","value":"3"}]},{"database":"InterPro","id":"IPR019749","properties":[{"key":"EntryName","value":"Band_41_domain"}]},{"database":"InterPro","id":"IPR035899","properties":[{"key":"EntryName","value":"DBL_dom_sf"}]},{"database":"InterPro","id":"IPR000219","properties":[{"key":"EntryName","value":"DH_dom"}]},{"database":"InterPro","id":"IPR000798","properties":[{"key":"EntryName","value":"Ez/rad/moesin-like"}]},{"database":"InterPro","id":"IPR014847","properties":[{"key":"EntryName","value":"FA"}]},{"database":"InterPro","id":"IPR041788","properties":[{"key":"EntryName","value":"FARP1/FARP2/FRMD7_FERM_C"}]},{"database":"InterPro","id":"IPR014352","properties":[{"key":"EntryName","value":"FERM/acyl-CoA-bd_prot_sf"}]},{"database":"InterPro","id":"IPR035963","properties":[{"key":"EntryName","value":"FERM_2"}]},{"database":"InterPro","id":"IPR019748","properties":[{"key":"EntryName","value":"FERM_central"}]},{"database":"InterPro","id":"IPR019747","properties":[{"key":"EntryName","value":"FERM_CS"}]},{"database":"InterPro","id":"IPR000299","properties":[{"key":"EntryName","value":"FERM_domain"}]},{"database":"InterPro","id":"IPR018979","properties":[{"key":"EntryName","value":"FERM_N"}]},{"database":"InterPro","id":"IPR018980","properties":[{"key":"EntryName","value":"FERM_PH-like_C"}]},{"database":"InterPro","id":"IPR011993","properties":[{"key":"EntryName","value":"PH-like_dom_sf"}]},{"database":"InterPro","id":"IPR001849","properties":[{"key":"EntryName","value":"PH_domain"}]},{"database":"InterPro","id":"IPR051835","properties":[{"key":"EntryName","value":"RAC1-GEF"}]},{"database":"InterPro","id":"IPR029071","properties":[{"key":"EntryName","value":"Ubiquitin-like_domsf"}]},{"database":"PANTHER","id":"PTHR45858","properties":[{"key":"EntryName","value":"FERM DOMAIN CONTAINING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR45858:SF2","properties":[{"key":"EntryName","value":"FERM, ARHGEF AND PLECKSTRIN DOMAIN-CONTAINING PROTEIN 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08736","properties":[{"key":"EntryName","value":"FA"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF09380","properties":[{"key":"EntryName","value":"FERM_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00373","properties":[{"key":"EntryName","value":"FERM_M"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF09379","properties":[{"key":"EntryName","value":"FERM_N"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00169","properties":[{"key":"EntryName","value":"PH"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF00621","properties":[{"key":"EntryName","value":"RhoGEF"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00935","properties":[{"key":"EntryName","value":"BAND41"}]},{"database":"PRINTS","id":"PR00661","properties":[{"key":"EntryName","value":"ERMFAMILY"}]},{"database":"SMART","id":"SM00295","properties":[{"key":"EntryName","value":"B41"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM01195","properties":[{"key":"EntryName","value":"FA"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM01196","properties":[{"key":"EntryName","value":"FERM_C"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00233","properties":[{"key":"EntryName","value":"PH"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00325","properties":[{"key":"EntryName","value":"RhoGEF"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48065","properties":[{"key":"EntryName","value":"DBL homology domain (DH-domain)"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF50729","properties":[{"key":"EntryName","value":"PH domain-like"},{"key":"MatchStatus","value":"3"}]},{"database":"SUPFAM","id":"SSF47031","properties":[{"key":"EntryName","value":"Second domain of FERM"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54236","properties":[{"key":"EntryName","value":"Ubiquitin-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50010","properties":[{"key":"EntryName","value":"DH_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00660","properties":[{"key":"EntryName","value":"FERM_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50057","properties":[{"key":"EntryName","value":"FERM_3"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50003","properties":[{"key":"EntryName","value":"PH_DOMAIN"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPQRAPGKVLLDAVCNHLNLVEGDYFGLEFPDHKKITVWLDLLKPIVKQIRRPKHVVVKFVVKFFPPDHTQLQEELTRYLFALQVKQDLAQGRLTCNDTSAALLISHIVQSEIGDFDEALDREHLAKNKYIPQQDALEDKIVEFHHNHIGQTPAESDFQLLEIARRLEMYGIRLHPAKDREGTKINLAVANTGILVFQGFTKINAFNWAKVRKLSFKRKRFLIKLRPDANSAYQDTLEFLMASRDFCKSFWKICVEHHAFFRLFEEPKPKPKPVLFSRGSSFRFSGRTQKQVLDYVKEGGHKKVQFERKHSKIHSIRSLASQPTELNSEVLEQSQQSTSLTFGEGAESPGGQSCRRGKEPKVSAGEPGSHPSPAPRRSPAGNKQADGAASAPTEEEEEVVKDRTQQSKPQPPQPSTGSLTGSPHLSELSVNSQGGVAPANVTLSPNLSPDTKQASPLISPLLNDQACPRTDDEDEGRRKRFPTDKAYFIAKEVSTTERTYLKDLEVITSWFQSTVSKEDAMPEALKSLIFPNFEPLHKFHTNFLKEIEQRLALWEGRSNAQIRDYQRIGDVMLKNIQGMKDPPPLLPPKHLAAHLWKHSEALEALENGIKSSRRLENFCRDFELQKVCYLPLNTFLLRPLHRLMHYKQVLERLCKHHPPSHADFRDCRAALAEITEMVAQLHGTMIKMENFQKLHELKKDLIGIDNLVVPGREFIRLGSLSKLSGKGLQQRMFFLFNDVLLYTSRGLTASNQFKVHGQLPLYGMTIEESEDEWGVPHCLTLRGQRQSIIVAASSRSEMEKWVEDIQMAIDLAEKSSSPAPEFLASSPPDNKSPDEATAADQESEDDLSASRTSLERQAPHRGNTMVHVCWHRNTSVSMVDFSIAVENQLSGNLLRKFKNSNGWQKLWVVFTNFCLFFYKSHQDNHPLASLPLLGYSLTIPSESENIQKDYVFKLHFKSHVYYFRAESEYTFERWMEVIRSATSSASRPHVLSHKESLVY","length":1054,"molWeight":119588,"crc64":"281B78E2EECC62E6","md5":"386FA3A998ED13FC7861E39576577B4E"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Domain":4,"Region":3,"Compositional bias":3},"uniParcId":"UPI0040317B37"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8T4P2","uniProtkbId":"A0ACI8T4P2_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000592638.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00040395"}],"value":"FERM, ARHGEF and pleckstrin domain-containing protein 1"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00042170"}],"value":"FERM, RhoGEF and pleckstrin domain-containing protein 1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000592638.1"}],"value":"FARP1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00054998"}],"value":"Functions as a guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00064538"}],"value":"Interacts with CADM1. Interacts with RAC1"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004413"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004413"}],"value":"Peripheral membrane protein","id":"SL-9903"},"orientation":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004413"}],"value":"Cytoplasmic side","id":"SL-9910"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004279"}],"value":"Cell projection, dendrite","id":"SL-0283"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004552"}],"value":"Cell projection, dendritic spine","id":"SL-0284"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004486"}],"value":"Cell projection, filopodium","id":"SL-0286"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004514"}],"value":"Cytoplasm, cytosol","id":"SL-0091"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00034102"}],"value":"Synapse, synaptosome","id":"SL-0261"}}]}],"features":[{"type":"Domain","location":{"start":{"value":40,"modifier":"EXACT"},"end":{"value":320,"modifier":"EXACT"}},"description":"FERM","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50057"}]},{"type":"Domain","location":{"start":{"value":566,"modifier":"EXACT"},"end":{"value":756,"modifier":"EXACT"}},"description":"DH","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50010"}]},{"type":"Domain","location":{"start":{"value":785,"modifier":"EXACT"},"end":{"value":882,"modifier":"EXACT"}},"description":"PH","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50003"}]},{"type":"Domain","location":{"start":{"value":958,"modifier":"EXACT"},"end":{"value":1055,"modifier":"EXACT"}},"description":"PH","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50003"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":37,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":361,"modifier":"EXACT"},"end":{"value":478,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":495,"modifier":"EXACT"},"end":{"value":537,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":890,"modifier":"EXACT"},"end":{"value":929,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":373,"modifier":"EXACT"},"end":{"value":396,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":496,"modifier":"EXACT"},"end":{"value":515,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":522,"modifier":"EXACT"},"end":{"value":537,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023273"}],"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022473"}],"id":"KW-0217","category":"Molecular function","name":"Developmental protein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022658"}],"id":"KW-0344","category":"Molecular function","name":"Guanine-nucleotide releasing factor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8T4P2"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8T4P2"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023018"}],"id":"KW-0770","category":"Cellular component","name":"Synapse"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022599"}],"id":"KW-0771","category":"Cellular component","name":"Synaptosome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000592638.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15057823","citationType":"journal article","authors":["Dunham A.","Matthews L.H.","Burton J.","Ashurst J.L.","Howe K.L.","Ashcroft K.J.","Beare D.M.","Burford D.C.","Hunt S.E.","Griffiths-Jones S.","Jones M.C.","Keenan S.J.","Oliver K.","Scott C.E.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Andrews D.T.","Ashwell R.I.","Babbage A.K.","Bagguley C.L.","Bailey J.","Bannerjee R.","Barlow K.F.","Bates K.","Beasley H.","Bird C.P.","Bray-Allen S.","Brown A.J.","Brown J.Y.","Burrill W.","Carder C.","Carter N.P.","Chapman J.C.","Clamp M.E.","Clark S.Y.","Clarke G.","Clee C.M.","Clegg S.C.","Cobley V.","Collins J.E.","Corby N.","Coville G.J.","Deloukas P.","Dhami P.","Dunham I.","Dunn M.","Earthrowl M.E.","Ellington A.G.","Faulkner L.","Frankish A.G.","Frankland J.","French L.","Garner P.","Garnett J.","Gilbert J.G.","Gilson C.J.","Ghori J.","Grafham D.V.","Gribble S.M.","Griffiths C.","Hall R.E.","Hammond S.","Harley J.L.","Hart E.A.","Heath P.D.","Howden P.J.","Huckle E.J.","Hunt P.J.","Hunt A.R.","Johnson C.","Johnson D.","Kay M.","Kimberley A.M.","King A.","Laird G.K.","Langford C.J.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Lloyd C.","Loveland J.E.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","McLaren S.J.","McMurray A.","Milne S.","Moore M.J.","Nickerson T.","Palmer S.A.","Pearce A.V.","Peck A.I.","Pelan S.","Phillimore B.","Porter K.M.","Rice C.M.","Searle S.","Sehra H.K.","Shownkeen R.","Skuce C.D.","Smith M.","Steward C.A.","Sycamore N.","Tester J.","Thomas D.W.","Tracey A.","Tromans A.","Tubby B.","Wall M.","Wallis J.M.","West A.P.","Whitehead S.L.","Willey D.L.","Wilming L.","Wray P.W.","Wright M.W.","Young L.","Coulson A.","Durbin R.","Hubbard T.","Sulston J.E.","Beck S.","Bentley D.R.","Rogers J.","Ross M.T."],"citationCrossReferences":[{"database":"PubMed","id":"15057823"},{"database":"DOI","id":"10.1038/nature02379"}],"title":"The DNA sequence and analysis of human chromosome 13.","publicationDate":"2004","journal":"Nature","firstPage":"522","lastPage":"528","volume":"428"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000592638.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000592638.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000592638.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL136300","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL137249","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL161896","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL445223","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"KF455815","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000922579.1","properties":[{"key":"ProteinId","value":"ENSP00000592638.1"},{"key":"GeneId","value":"ENSG00000152767.18"}]},{"database":"HGNC","id":"HGNC:3591","properties":[{"key":"GeneName","value":"FARP1"}]},{"database":"OpenTargets","id":"ENSG00000152767","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000155318","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 13"}]},{"database":"CDD","id":"cd14473","properties":[{"key":"EntryName","value":"FERM_B-lobe"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd13193","properties":[{"key":"EntryName","value":"FERM_C_FARP1-like"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd01220","properties":[{"key":"EntryName","value":"PH1_FARP1-like"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd13235","properties":[{"key":"EntryName","value":"PH2_FARP1-like"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd00160","properties":[{"key":"EntryName","value":"RhoGEF"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.30.29.30:FF:000002","properties":[{"key":"EntryName","value":"Band 4.1-like protein 5 isoform 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.10.20.90:FF:000040","properties":[{"key":"EntryName","value":"FERM, RhoGEF and pleckstrin domain-containing protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.80.10:FF:000005","properties":[{"key":"EntryName","value":"FERM, RhoGEF and pleckstrin domain-containing protein 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.900.10:FF:000021","properties":[{"key":"EntryName","value":"FERM, RhoGEF and pleckstrin domain-containing protein 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.30.29.30:FF:000046","properties":[{"key":"EntryName","value":"FERM, RhoGEF and pleckstrin domain-containing protein 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.80.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.900.10","properties":[{"key":"EntryName","value":"Dbl homology (DH) domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.10.20.90","properties":[{"key":"EntryName","value":"Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.30.29.30","properties":[{"key":"EntryName","value":"Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"},{"key":"MatchStatus","value":"3"}]},{"database":"InterPro","id":"IPR019749","properties":[{"key":"EntryName","value":"Band_41_domain"}]},{"database":"InterPro","id":"IPR035899","properties":[{"key":"EntryName","value":"DBL_dom_sf"}]},{"database":"InterPro","id":"IPR000219","properties":[{"key":"EntryName","value":"DH_dom"}]},{"database":"InterPro","id":"IPR000798","properties":[{"key":"EntryName","value":"Ez/rad/moesin-like"}]},{"database":"InterPro","id":"IPR014847","properties":[{"key":"EntryName","value":"FA"}]},{"database":"InterPro","id":"IPR041788","properties":[{"key":"EntryName","value":"FARP1/FARP2/FRMD7_FERM_C"}]},{"database":"InterPro","id":"IPR014352","properties":[{"key":"EntryName","value":"FERM/acyl-CoA-bd_prot_sf"}]},{"database":"InterPro","id":"IPR035963","properties":[{"key":"EntryName","value":"FERM_2"}]},{"database":"InterPro","id":"IPR019748","properties":[{"key":"EntryName","value":"FERM_central"}]},{"database":"InterPro","id":"IPR019747","properties":[{"key":"EntryName","value":"FERM_CS"}]},{"database":"InterPro","id":"IPR000299","properties":[{"key":"EntryName","value":"FERM_domain"}]},{"database":"InterPro","id":"IPR018979","properties":[{"key":"EntryName","value":"FERM_N"}]},{"database":"InterPro","id":"IPR018980","properties":[{"key":"EntryName","value":"FERM_PH-like_C"}]},{"database":"InterPro","id":"IPR011993","properties":[{"key":"EntryName","value":"PH-like_dom_sf"}]},{"database":"InterPro","id":"IPR001849","properties":[{"key":"EntryName","value":"PH_domain"}]},{"database":"InterPro","id":"IPR051835","properties":[{"key":"EntryName","value":"RAC1-GEF"}]},{"database":"InterPro","id":"IPR029071","properties":[{"key":"EntryName","value":"Ubiquitin-like_domsf"}]},{"database":"PANTHER","id":"PTHR45858","properties":[{"key":"EntryName","value":"FERM DOMAIN CONTAINING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR45858:SF2","properties":[{"key":"EntryName","value":"FERM, ARHGEF AND PLECKSTRIN DOMAIN-CONTAINING PROTEIN 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08736","properties":[{"key":"EntryName","value":"FA"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF09380","properties":[{"key":"EntryName","value":"FERM_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00373","properties":[{"key":"EntryName","value":"FERM_M"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF09379","properties":[{"key":"EntryName","value":"FERM_N"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00169","properties":[{"key":"EntryName","value":"PH"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF00621","properties":[{"key":"EntryName","value":"RhoGEF"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00935","properties":[{"key":"EntryName","value":"BAND41"}]},{"database":"PRINTS","id":"PR00661","properties":[{"key":"EntryName","value":"ERMFAMILY"}]},{"database":"SMART","id":"SM00295","properties":[{"key":"EntryName","value":"B41"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM01195","properties":[{"key":"EntryName","value":"FA"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM01196","properties":[{"key":"EntryName","value":"FERM_C"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00233","properties":[{"key":"EntryName","value":"PH"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00325","properties":[{"key":"EntryName","value":"RhoGEF"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48065","properties":[{"key":"EntryName","value":"DBL homology domain (DH-domain)"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF50729","properties":[{"key":"EntryName","value":"PH domain-like"},{"key":"MatchStatus","value":"3"}]},{"database":"SUPFAM","id":"SSF47031","properties":[{"key":"EntryName","value":"Second domain of FERM"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54236","properties":[{"key":"EntryName","value":"Ubiquitin-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50010","properties":[{"key":"EntryName","value":"DH_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00660","properties":[{"key":"EntryName","value":"FERM_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50057","properties":[{"key":"EntryName","value":"FERM_3"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50003","properties":[{"key":"EntryName","value":"PH_DOMAIN"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPQRAPGKVLLDAVCNHLNLVEGDYFGLEFPDHKKITVWLDLLKPIVKQIRRPKHVVVKFVVKFFPPDHTQLQEELTRYLFALQVKQDLAQGRLTCNDTSAALLISHIVQSEIGDFDEALDREHLAKNKYIPQQDALEDKIVEFHHNHIGQTPAESDFQLLEIARRLEMYGIRLHPAKDREGTKINLAVANTGILVFQGFTKINAFNWAKVRKLSFKRKRFLIKLRPDANSAYQDTLEFLMASRDFCKSFWKICVEHHAFFRLFEEPKPKPKPVLFSRGSSFRFSGRTQKQVLDYVKEGGHKKVQFERKHSKIHSIRSLASQPTELNSEVLEQSQQSTSLTFGEGAESPGGQSCRRGKEPKVSAGEPGSHPSPAPRRSPAGNKQADGAASAPTEEEEEVVKDRTQQSKPQPPQPSTGTGSKKHTYITLNNLRYQEEDHTANMGSLTGSPHLSELSVNSQGGVAPANVTLSPNLSPDTKQASPLISPLLNDQACPRTDDEDEGRRKRFPTDKAYFIAKEVSTTERTYLKDLEVITSWFQSTVSKEDAMPEALKSLIFPNFEPLHKFHTNFLKEIEQRLALWEGRSNAQIRDYQRIGDVMLKNIQGMKHLAAHLWKHSEALEALENGIKSSRRLENFCRDFELQKVCYLPLNTFLLRPLHRLMHYKQVLERLCKHHPPSHADFRDCRAALAEITEMVAQLHGTMIKMENFQKLHELKKDLIGIDNLVVPGREFIRLGSLSKLSGKGLQQRMFFLFNDVLLYTSRGLTASNQFKVHGQLPLYGMTIEESEDEWGVPHCLTLRGQRQSIIVAASSRSEMEKWVEDIQMAIDLAEKSSSPAPEFLASSPPDNKSPDEATAADQESEDDLSASRTSLERQAPHRGNTMVHVCWHRNTSVSMVDFSIAVENQLSGNLLRKFKNSNGWQKLWVVFTNFCLFFYKSHQDNHPLASLPLLGYSLTIPSESENIQKDYVFKLHFKSHVYYFRAESEYTFERWMEVIRSATSSASRPHVLSHKESLVY","length":1071,"molWeight":121637,"crc64":"5A17A9D19FDD8974","md5":"C37EB46CDE8D44E9BD1B2DCF5D765FFC"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Domain":4,"Region":4,"Compositional bias":3},"uniParcId":"UPI0040318CD3"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8V9J9","uniProtkbId":"A0ACI8V9J9_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000634253.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00040395"}],"value":"FERM, ARHGEF and pleckstrin domain-containing protein 1"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00042170"}],"value":"FERM, RhoGEF and pleckstrin domain-containing protein 1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000634253.1"}],"value":"FARP1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00054998"}],"value":"Functions as a guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00064538"}],"value":"Interacts with CADM1. Interacts with RAC1"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004413"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004413"}],"value":"Peripheral membrane protein","id":"SL-9903"},"orientation":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004413"}],"value":"Cytoplasmic side","id":"SL-9910"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004279"}],"value":"Cell projection, dendrite","id":"SL-0283"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004552"}],"value":"Cell projection, dendritic spine","id":"SL-0284"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004486"}],"value":"Cell projection, filopodium","id":"SL-0286"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004514"}],"value":"Cytoplasm, cytosol","id":"SL-0091"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00034102"}],"value":"Synapse, synaptosome","id":"SL-0261"}}]}],"features":[{"type":"Domain","location":{"start":{"value":40,"modifier":"EXACT"},"end":{"value":320,"modifier":"EXACT"}},"description":"FERM","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50057"}]},{"type":"Domain","location":{"start":{"value":540,"modifier":"EXACT"},"end":{"value":730,"modifier":"EXACT"}},"description":"DH","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50010"}]},{"type":"Domain","location":{"start":{"value":759,"modifier":"EXACT"},"end":{"value":856,"modifier":"EXACT"}},"description":"PH","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50003"}]},{"type":"Domain","location":{"start":{"value":932,"modifier":"EXACT"},"end":{"value":1038,"modifier":"EXACT"}},"description":"PH","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50003"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":37,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":361,"modifier":"EXACT"},"end":{"value":534,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":864,"modifier":"EXACT"},"end":{"value":902,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":373,"modifier":"EXACT"},"end":{"value":396,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":471,"modifier":"EXACT"},"end":{"value":489,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":496,"modifier":"EXACT"},"end":{"value":511,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023273"}],"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022473"}],"id":"KW-0217","category":"Molecular function","name":"Developmental protein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022658"}],"id":"KW-0344","category":"Molecular function","name":"Guanine-nucleotide releasing factor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8V9J9"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8V9J9"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023018"}],"id":"KW-0770","category":"Cellular component","name":"Synapse"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022599"}],"id":"KW-0771","category":"Cellular component","name":"Synaptosome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000634253.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15057823","citationType":"journal article","authors":["Dunham A.","Matthews L.H.","Burton J.","Ashurst J.L.","Howe K.L.","Ashcroft K.J.","Beare D.M.","Burford D.C.","Hunt S.E.","Griffiths-Jones S.","Jones M.C.","Keenan S.J.","Oliver K.","Scott C.E.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Andrews D.T.","Ashwell R.I.","Babbage A.K.","Bagguley C.L.","Bailey J.","Bannerjee R.","Barlow K.F.","Bates K.","Beasley H.","Bird C.P.","Bray-Allen S.","Brown A.J.","Brown J.Y.","Burrill W.","Carder C.","Carter N.P.","Chapman J.C.","Clamp M.E.","Clark S.Y.","Clarke G.","Clee C.M.","Clegg S.C.","Cobley V.","Collins J.E.","Corby N.","Coville G.J.","Deloukas P.","Dhami P.","Dunham I.","Dunn M.","Earthrowl M.E.","Ellington A.G.","Faulkner L.","Frankish A.G.","Frankland J.","French L.","Garner P.","Garnett J.","Gilbert J.G.","Gilson C.J.","Ghori J.","Grafham D.V.","Gribble S.M.","Griffiths C.","Hall R.E.","Hammond S.","Harley J.L.","Hart E.A.","Heath P.D.","Howden P.J.","Huckle E.J.","Hunt P.J.","Hunt A.R.","Johnson C.","Johnson D.","Kay M.","Kimberley A.M.","King A.","Laird G.K.","Langford C.J.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Lloyd C.","Loveland J.E.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","McLaren S.J.","McMurray A.","Milne S.","Moore M.J.","Nickerson T.","Palmer S.A.","Pearce A.V.","Peck A.I.","Pelan S.","Phillimore B.","Porter K.M.","Rice C.M.","Searle S.","Sehra H.K.","Shownkeen R.","Skuce C.D.","Smith M.","Steward C.A.","Sycamore N.","Tester J.","Thomas D.W.","Tracey A.","Tromans A.","Tubby B.","Wall M.","Wallis J.M.","West A.P.","Whitehead S.L.","Willey D.L.","Wilming L.","Wray P.W.","Wright M.W.","Young L.","Coulson A.","Durbin R.","Hubbard T.","Sulston J.E.","Beck S.","Bentley D.R.","Rogers J.","Ross M.T."],"citationCrossReferences":[{"database":"PubMed","id":"15057823"},{"database":"DOI","id":"10.1038/nature02379"}],"title":"The DNA sequence and analysis of human chromosome 13.","publicationDate":"2004","journal":"Nature","firstPage":"522","lastPage":"528","volume":"428"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000634253.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000634253.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000634253.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL136300","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL137249","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL161896","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL445223","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"KF455815","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000964194.1","properties":[{"key":"ProteinId","value":"ENSP00000634253.1"},{"key":"GeneId","value":"ENSG00000152767.18"}]},{"database":"HGNC","id":"HGNC:3591","properties":[{"key":"GeneName","value":"FARP1"}]},{"database":"OpenTargets","id":"ENSG00000152767","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000155318","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 13"}]},{"database":"CDD","id":"cd14473","properties":[{"key":"EntryName","value":"FERM_B-lobe"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd13193","properties":[{"key":"EntryName","value":"FERM_C_FARP1-like"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd01220","properties":[{"key":"EntryName","value":"PH1_FARP1-like"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd13235","properties":[{"key":"EntryName","value":"PH2_FARP1-like"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd00160","properties":[{"key":"EntryName","value":"RhoGEF"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.30.29.30:FF:000002","properties":[{"key":"EntryName","value":"Band 4.1-like protein 5 isoform 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.10.20.90:FF:000040","properties":[{"key":"EntryName","value":"FERM, RhoGEF and pleckstrin domain-containing protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.80.10:FF:000005","properties":[{"key":"EntryName","value":"FERM, RhoGEF and pleckstrin domain-containing protein 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.900.10:FF:000021","properties":[{"key":"EntryName","value":"FERM, RhoGEF and pleckstrin domain-containing protein 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.30.29.30:FF:000046","properties":[{"key":"EntryName","value":"FERM, RhoGEF and pleckstrin domain-containing protein 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.80.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.900.10","properties":[{"key":"EntryName","value":"Dbl homology (DH) domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.10.20.90","properties":[{"key":"EntryName","value":"Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.30.29.30","properties":[{"key":"EntryName","value":"Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"},{"key":"MatchStatus","value":"3"}]},{"database":"InterPro","id":"IPR019749","properties":[{"key":"EntryName","value":"Band_41_domain"}]},{"database":"InterPro","id":"IPR035899","properties":[{"key":"EntryName","value":"DBL_dom_sf"}]},{"database":"InterPro","id":"IPR000219","properties":[{"key":"EntryName","value":"DH_dom"}]},{"database":"InterPro","id":"IPR000798","properties":[{"key":"EntryName","value":"Ez/rad/moesin-like"}]},{"database":"InterPro","id":"IPR014847","properties":[{"key":"EntryName","value":"FA"}]},{"database":"InterPro","id":"IPR041788","properties":[{"key":"EntryName","value":"FARP1/FARP2/FRMD7_FERM_C"}]},{"database":"InterPro","id":"IPR014352","properties":[{"key":"EntryName","value":"FERM/acyl-CoA-bd_prot_sf"}]},{"database":"InterPro","id":"IPR035963","properties":[{"key":"EntryName","value":"FERM_2"}]},{"database":"InterPro","id":"IPR019748","properties":[{"key":"EntryName","value":"FERM_central"}]},{"database":"InterPro","id":"IPR019747","properties":[{"key":"EntryName","value":"FERM_CS"}]},{"database":"InterPro","id":"IPR000299","properties":[{"key":"EntryName","value":"FERM_domain"}]},{"database":"InterPro","id":"IPR018979","properties":[{"key":"EntryName","value":"FERM_N"}]},{"database":"InterPro","id":"IPR018980","properties":[{"key":"EntryName","value":"FERM_PH-like_C"}]},{"database":"InterPro","id":"IPR011993","properties":[{"key":"EntryName","value":"PH-like_dom_sf"}]},{"database":"InterPro","id":"IPR001849","properties":[{"key":"EntryName","value":"PH_domain"}]},{"database":"InterPro","id":"IPR051835","properties":[{"key":"EntryName","value":"RAC1-GEF"}]},{"database":"InterPro","id":"IPR029071","properties":[{"key":"EntryName","value":"Ubiquitin-like_domsf"}]},{"database":"PANTHER","id":"PTHR45858","properties":[{"key":"EntryName","value":"FERM DOMAIN CONTAINING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR45858:SF2","properties":[{"key":"EntryName","value":"FERM, ARHGEF AND PLECKSTRIN DOMAIN-CONTAINING PROTEIN 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08736","properties":[{"key":"EntryName","value":"FA"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF09380","properties":[{"key":"EntryName","value":"FERM_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00373","properties":[{"key":"EntryName","value":"FERM_M"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF09379","properties":[{"key":"EntryName","value":"FERM_N"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00169","properties":[{"key":"EntryName","value":"PH"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF00621","properties":[{"key":"EntryName","value":"RhoGEF"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00935","properties":[{"key":"EntryName","value":"BAND41"}]},{"database":"PRINTS","id":"PR00661","properties":[{"key":"EntryName","value":"ERMFAMILY"}]},{"database":"SMART","id":"SM00295","properties":[{"key":"EntryName","value":"B41"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM01195","properties":[{"key":"EntryName","value":"FA"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM01196","properties":[{"key":"EntryName","value":"FERM_C"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00233","properties":[{"key":"EntryName","value":"PH"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00325","properties":[{"key":"EntryName","value":"RhoGEF"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48065","properties":[{"key":"EntryName","value":"DBL homology domain (DH-domain)"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF50729","properties":[{"key":"EntryName","value":"PH domain-like"},{"key":"MatchStatus","value":"3"}]},{"database":"SUPFAM","id":"SSF47031","properties":[{"key":"EntryName","value":"Second domain of FERM"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54236","properties":[{"key":"EntryName","value":"Ubiquitin-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50010","properties":[{"key":"EntryName","value":"DH_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00660","properties":[{"key":"EntryName","value":"FERM_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50057","properties":[{"key":"EntryName","value":"FERM_3"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50003","properties":[{"key":"EntryName","value":"PH_DOMAIN"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPQRAPGKVLLDAVCNHLNLVEGDYFGLEFPDHKKITVWLDLLKPIVKQIRRPKHVVVKFVVKFFPPDHTQLQEELTRYLFALQVKQDLAQGRLTCNDTSAALLISHIVQSEIGDFDEALDREHLAKNKYIPQQDALEDKIVEFHHNHIGQTPAESDFQLLEIARRLEMYGIRLHPAKDREGTKINLAVANTGILVFQGFTKINAFNWAKVRKLSFKRKRFLIKLRPDANSAYQDTLEFLMASRDFCKSFWKICVEHHAFFRLFEEPKPKPKPVLFSRGSSFRFSGRTQKQVLDYVKEGGHKKVQFERKHSKIHSIRSLASQPTELNSEVLEQSQQSTSLTFGEGAESPGGQSCRRGKEPKVSAGEPGSHPSPAPRRSPAGNKQADGAASAPTEEEEEVVKDRTQQSKPQPPQPSTGSLTGSPHLSELSVNSQGGVAPANVTLSPNLSPDTKQASPLISPLLNDQACPRTDDEDEGRRKRFPTDKAYFIAKEVSTTERTYLKDLEVITSWFQSTVSKEDAMPEALKSLIFPNFEPLHKFHTNFLKEIEQRLALWEGRSNAQIRDYQRIGDVMLKNIQGMKHLAAHLWKHSEALEALENGIKSSRRLENFCRDFELQKVCYLPLNTFLLRPLHRLMHYKQVLERLCKHHPPSHADFRDCRAALAEITEMVAQLHGTMIKMENFQKLHELKKDLIGIDNLVVPGREFIRLGSLSKLSGKGLQQRMFFLFNDVLLYTSRGLTASNQFKVHGQLPLYGMTIEESEDEWGVPHCLTLRGQRQSIIVAASSRSEMEKWVEDIQMAIDLAEKSSSPAPEFLASSPPDNKSPDEATAADQESEDDLSASRTSLERQAPHRGNTMVHVCWHRNTSVSMVDFSIAVENQLSGNLLRKFKNSNGWQKLWVVFTNFCLFFYKSHQPLCFVSPFQDNHPLASLPLLGYSLTIPSESENIQKDYVFKLHFKSHVYYFRAESEYTFERWMEVIRSATSSASRPHVLSHKESLVY","length":1054,"molWeight":119652,"crc64":"7C7B34ABD2EF71EC","md5":"6C04B0DD199B6299B7BC4DAE804D7B0E"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Domain":4,"Region":3,"Compositional bias":3},"uniParcId":"UPI00403174E5"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8Q5J8","uniProtkbId":"A0ACI8Q5J8_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000541561.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00040395"}],"value":"FERM, ARHGEF and pleckstrin domain-containing protein 1"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00042170"}],"value":"FERM, RhoGEF and pleckstrin domain-containing protein 1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000541561.1"}],"value":"FARP1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00054998"}],"value":"Functions as a guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00064538"}],"value":"Interacts with CADM1. Interacts with RAC1"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004413"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004413"}],"value":"Peripheral membrane protein","id":"SL-9903"},"orientation":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004413"}],"value":"Cytoplasmic side","id":"SL-9910"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004279"}],"value":"Cell projection, dendrite","id":"SL-0283"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004552"}],"value":"Cell projection, dendritic spine","id":"SL-0284"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004486"}],"value":"Cell projection, filopodium","id":"SL-0286"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004514"}],"value":"Cytoplasm, cytosol","id":"SL-0091"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00034102"}],"value":"Synapse, synaptosome","id":"SL-0261"}}]}],"features":[{"type":"Domain","location":{"start":{"value":40,"modifier":"EXACT"},"end":{"value":320,"modifier":"EXACT"}},"description":"FERM","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50057"}]},{"type":"Domain","location":{"start":{"value":530,"modifier":"EXACT"},"end":{"value":720,"modifier":"EXACT"}},"description":"DH","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50010"}]},{"type":"Domain","location":{"start":{"value":749,"modifier":"EXACT"},"end":{"value":846,"modifier":"EXACT"}},"description":"PH","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50003"}]},{"type":"Domain","location":{"start":{"value":922,"modifier":"EXACT"},"end":{"value":1019,"modifier":"EXACT"}},"description":"PH","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50003"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":37,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":361,"modifier":"EXACT"},"end":{"value":524,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":854,"modifier":"EXACT"},"end":{"value":893,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":373,"modifier":"EXACT"},"end":{"value":396,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":460,"modifier":"EXACT"},"end":{"value":479,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":486,"modifier":"EXACT"},"end":{"value":501,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023273"}],"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022473"}],"id":"KW-0217","category":"Molecular function","name":"Developmental protein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022658"}],"id":"KW-0344","category":"Molecular function","name":"Guanine-nucleotide releasing factor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8Q5J8"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8Q5J8"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023018"}],"id":"KW-0770","category":"Cellular component","name":"Synapse"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022599"}],"id":"KW-0771","category":"Cellular component","name":"Synaptosome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000541561.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15057823","citationType":"journal article","authors":["Dunham A.","Matthews L.H.","Burton J.","Ashurst J.L.","Howe K.L.","Ashcroft K.J.","Beare D.M.","Burford D.C.","Hunt S.E.","Griffiths-Jones S.","Jones M.C.","Keenan S.J.","Oliver K.","Scott C.E.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Andrews D.T.","Ashwell R.I.","Babbage A.K.","Bagguley C.L.","Bailey J.","Bannerjee R.","Barlow K.F.","Bates K.","Beasley H.","Bird C.P.","Bray-Allen S.","Brown A.J.","Brown J.Y.","Burrill W.","Carder C.","Carter N.P.","Chapman J.C.","Clamp M.E.","Clark S.Y.","Clarke G.","Clee C.M.","Clegg S.C.","Cobley V.","Collins J.E.","Corby N.","Coville G.J.","Deloukas P.","Dhami P.","Dunham I.","Dunn M.","Earthrowl M.E.","Ellington A.G.","Faulkner L.","Frankish A.G.","Frankland J.","French L.","Garner P.","Garnett J.","Gilbert J.G.","Gilson C.J.","Ghori J.","Grafham D.V.","Gribble S.M.","Griffiths C.","Hall R.E.","Hammond S.","Harley J.L.","Hart E.A.","Heath P.D.","Howden P.J.","Huckle E.J.","Hunt P.J.","Hunt A.R.","Johnson C.","Johnson D.","Kay M.","Kimberley A.M.","King A.","Laird G.K.","Langford C.J.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Lloyd C.","Loveland J.E.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","McLaren S.J.","McMurray A.","Milne S.","Moore M.J.","Nickerson T.","Palmer S.A.","Pearce A.V.","Peck A.I.","Pelan S.","Phillimore B.","Porter K.M.","Rice C.M.","Searle S.","Sehra H.K.","Shownkeen R.","Skuce C.D.","Smith M.","Steward C.A.","Sycamore N.","Tester J.","Thomas D.W.","Tracey A.","Tromans A.","Tubby B.","Wall M.","Wallis J.M.","West A.P.","Whitehead S.L.","Willey D.L.","Wilming L.","Wray P.W.","Wright M.W.","Young L.","Coulson A.","Durbin R.","Hubbard T.","Sulston J.E.","Beck S.","Bentley D.R.","Rogers J.","Ross M.T."],"citationCrossReferences":[{"database":"PubMed","id":"15057823"},{"database":"DOI","id":"10.1038/nature02379"}],"title":"The DNA sequence and analysis of human chromosome 13.","publicationDate":"2004","journal":"Nature","firstPage":"522","lastPage":"528","volume":"428"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000541561.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000541561.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000541561.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL136300","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL137249","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL161896","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL445223","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"KF455815","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000871502.1","properties":[{"key":"ProteinId","value":"ENSP00000541561.1"},{"key":"GeneId","value":"ENSG00000152767.18"}]},{"database":"HGNC","id":"HGNC:3591","properties":[{"key":"GeneName","value":"FARP1"}]},{"database":"OpenTargets","id":"ENSG00000152767","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000155318","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 13"}]},{"database":"CDD","id":"cd14473","properties":[{"key":"EntryName","value":"FERM_B-lobe"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd13193","properties":[{"key":"EntryName","value":"FERM_C_FARP1-like"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd01220","properties":[{"key":"EntryName","value":"PH1_FARP1-like"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd13235","properties":[{"key":"EntryName","value":"PH2_FARP1-like"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd00160","properties":[{"key":"EntryName","value":"RhoGEF"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.30.29.30:FF:000002","properties":[{"key":"EntryName","value":"Band 4.1-like protein 5 isoform 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.10.20.90:FF:000040","properties":[{"key":"EntryName","value":"FERM, RhoGEF and pleckstrin domain-containing protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.80.10:FF:000005","properties":[{"key":"EntryName","value":"FERM, RhoGEF and pleckstrin domain-containing protein 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.900.10:FF:000021","properties":[{"key":"EntryName","value":"FERM, RhoGEF and pleckstrin domain-containing protein 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.30.29.30:FF:000046","properties":[{"key":"EntryName","value":"FERM, RhoGEF and pleckstrin domain-containing protein 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.80.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.900.10","properties":[{"key":"EntryName","value":"Dbl homology (DH) domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.10.20.90","properties":[{"key":"EntryName","value":"Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.30.29.30","properties":[{"key":"EntryName","value":"Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"},{"key":"MatchStatus","value":"3"}]},{"database":"InterPro","id":"IPR019749","properties":[{"key":"EntryName","value":"Band_41_domain"}]},{"database":"InterPro","id":"IPR035899","properties":[{"key":"EntryName","value":"DBL_dom_sf"}]},{"database":"InterPro","id":"IPR000219","properties":[{"key":"EntryName","value":"DH_dom"}]},{"database":"InterPro","id":"IPR000798","properties":[{"key":"EntryName","value":"Ez/rad/moesin-like"}]},{"database":"InterPro","id":"IPR014847","properties":[{"key":"EntryName","value":"FA"}]},{"database":"InterPro","id":"IPR041788","properties":[{"key":"EntryName","value":"FARP1/FARP2/FRMD7_FERM_C"}]},{"database":"InterPro","id":"IPR014352","properties":[{"key":"EntryName","value":"FERM/acyl-CoA-bd_prot_sf"}]},{"database":"InterPro","id":"IPR035963","properties":[{"key":"EntryName","value":"FERM_2"}]},{"database":"InterPro","id":"IPR019748","properties":[{"key":"EntryName","value":"FERM_central"}]},{"database":"InterPro","id":"IPR019747","properties":[{"key":"EntryName","value":"FERM_CS"}]},{"database":"InterPro","id":"IPR000299","properties":[{"key":"EntryName","value":"FERM_domain"}]},{"database":"InterPro","id":"IPR018979","properties":[{"key":"EntryName","value":"FERM_N"}]},{"database":"InterPro","id":"IPR018980","properties":[{"key":"EntryName","value":"FERM_PH-like_C"}]},{"database":"InterPro","id":"IPR011993","properties":[{"key":"EntryName","value":"PH-like_dom_sf"}]},{"database":"InterPro","id":"IPR001849","properties":[{"key":"EntryName","value":"PH_domain"}]},{"database":"InterPro","id":"IPR051835","properties":[{"key":"EntryName","value":"RAC1-GEF"}]},{"database":"InterPro","id":"IPR029071","properties":[{"key":"EntryName","value":"Ubiquitin-like_domsf"}]},{"database":"PANTHER","id":"PTHR45858","properties":[{"key":"EntryName","value":"FERM DOMAIN CONTAINING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR45858:SF2","properties":[{"key":"EntryName","value":"FERM, ARHGEF AND PLECKSTRIN DOMAIN-CONTAINING PROTEIN 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08736","properties":[{"key":"EntryName","value":"FA"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF09380","properties":[{"key":"EntryName","value":"FERM_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00373","properties":[{"key":"EntryName","value":"FERM_M"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF09379","properties":[{"key":"EntryName","value":"FERM_N"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00169","properties":[{"key":"EntryName","value":"PH"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF00621","properties":[{"key":"EntryName","value":"RhoGEF"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00935","properties":[{"key":"EntryName","value":"BAND41"}]},{"database":"PRINTS","id":"PR00661","properties":[{"key":"EntryName","value":"ERMFAMILY"}]},{"database":"SMART","id":"SM00295","properties":[{"key":"EntryName","value":"B41"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM01195","properties":[{"key":"EntryName","value":"FA"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM01196","properties":[{"key":"EntryName","value":"FERM_C"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00233","properties":[{"key":"EntryName","value":"PH"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00325","properties":[{"key":"EntryName","value":"RhoGEF"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48065","properties":[{"key":"EntryName","value":"DBL homology domain (DH-domain)"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF50729","properties":[{"key":"EntryName","value":"PH domain-like"},{"key":"MatchStatus","value":"3"}]},{"database":"SUPFAM","id":"SSF47031","properties":[{"key":"EntryName","value":"Second domain of FERM"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54236","properties":[{"key":"EntryName","value":"Ubiquitin-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50010","properties":[{"key":"EntryName","value":"DH_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00660","properties":[{"key":"EntryName","value":"FERM_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50057","properties":[{"key":"EntryName","value":"FERM_3"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50003","properties":[{"key":"EntryName","value":"PH_DOMAIN"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPQRAPGKVLLDAVCNHLNLVEGDYFGLEFPDHKKITVWLDLLKPIVKQIRRPKHVVVKFVVKFFPPDHTQLQEELTRYLFALQVKQDLAQGRLTCNDTSAALLISHIVQSEIGDFDEALDREHLAKNKYIPQQDALEDKIVEFHHNHIGQTPAESDFQLLEIARRLEMYGIRLHPAKDREGTKINLAVANTGILVFQGFTKINAFNWAKVRKLSFKRKRFLIKLRPDANSAYQDTLEFLMASRDFCKSFWKICVEHHAFFRLFEEPKPKPKPVLFSRGSSFRFSGRTQKQVLDYVKEGGHKKVQFERKHSKIHSIRSLASQPTELNSEVLEQSQQSTSLTFGEGAESPGGQSCRRGKEPKVSAGEPGSHPSPAPRRSPAGNKQADGAASAPTEEEEEVVKDRTQQSSLTGSPHLSELSVNSQGGVAPANVTLSPNLSPDTKQASPLISPLLNDQACPRTDDEDEGRRKRFPTDKAYFIAKEVSTTERTYLKDLEVITSWFQSTVSKEDAMPEALKSLIFPNFEPLHKFHTNFLKEIEQRLALWEGRSNAQIRDYQRIGDVMLKNIQGMKHLAAHLWKHSEALEALENGIKSSRRLENFCRDFELQKVCYLPLNTFLLRPLHRLMHYKQVLERLCKHHPPSHADFRDCRAALAEITEMVAQLHGTMIKMENFQKLHELKKDLIGIDNLVVPGREFIRLGSLSKLSGKGLQQRMFFLFNDVLLYTSRGLTASNQFKVHGQLPLYGMTIEESEDEWGVPHCLTLRGQRQSIIVAASSRSEMEKWVEDIQMAIDLAEKSSSPAPEFLASSPPDNKSPDEATAADQESEDDLSASRTSLERQAPHRGNTMVHVCWHRNTSVSMVDFSIAVENQLSGNLLRKFKNSNGWQKLWVVFTNFCLFFYKSHQDNHPLASLPLLGYSLTIPSESENIQKDYVFKLHFKSHVYYFRAESEYTFERWMEVIRSATSSASRPHVLSHKESLVY","length":1035,"molWeight":117615,"crc64":"6749AAB9FE443B13","md5":"54CAED860B79FCB22E0665A6319C7711"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Domain":4,"Region":3,"Compositional bias":3},"uniParcId":"UPI004031E7A2"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8QD97","uniProtkbId":"A0ACI8QD97_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000541563.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00040395"}],"value":"FERM, ARHGEF and pleckstrin domain-containing protein 1"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00042170"}],"value":"FERM, RhoGEF and pleckstrin domain-containing protein 1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000541563.1"}],"value":"FARP1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00054998"}],"value":"Functions as a guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00064538"}],"value":"Interacts with CADM1. Interacts with RAC1"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004413"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004413"}],"value":"Peripheral membrane protein","id":"SL-9903"},"orientation":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004413"}],"value":"Cytoplasmic side","id":"SL-9910"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004279"}],"value":"Cell projection, dendrite","id":"SL-0283"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004552"}],"value":"Cell projection, dendritic spine","id":"SL-0284"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004486"}],"value":"Cell projection, filopodium","id":"SL-0286"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004514"}],"value":"Cytoplasm, cytosol","id":"SL-0091"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00034102"}],"value":"Synapse, synaptosome","id":"SL-0261"}}]}],"features":[{"type":"Domain","location":{"start":{"value":40,"modifier":"EXACT"},"end":{"value":320,"modifier":"EXACT"}},"description":"FERM","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50057"}]},{"type":"Domain","location":{"start":{"value":540,"modifier":"EXACT"},"end":{"value":730,"modifier":"EXACT"}},"description":"DH","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50010"}]},{"type":"Domain","location":{"start":{"value":759,"modifier":"EXACT"},"end":{"value":856,"modifier":"EXACT"}},"description":"PH","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50003"}]},{"type":"Domain","location":{"start":{"value":960,"modifier":"EXACT"},"end":{"value":1057,"modifier":"EXACT"}},"description":"PH","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50003"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":37,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":361,"modifier":"EXACT"},"end":{"value":534,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":862,"modifier":"EXACT"},"end":{"value":932,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":373,"modifier":"EXACT"},"end":{"value":396,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":471,"modifier":"EXACT"},"end":{"value":489,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":496,"modifier":"EXACT"},"end":{"value":511,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":873,"modifier":"EXACT"},"end":{"value":905,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023273"}],"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022473"}],"id":"KW-0217","category":"Molecular function","name":"Developmental protein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022658"}],"id":"KW-0344","category":"Molecular function","name":"Guanine-nucleotide releasing factor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8QD97"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8QD97"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023018"}],"id":"KW-0770","category":"Cellular component","name":"Synapse"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022599"}],"id":"KW-0771","category":"Cellular component","name":"Synaptosome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000541563.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15057823","citationType":"journal article","authors":["Dunham A.","Matthews L.H.","Burton J.","Ashurst J.L.","Howe K.L.","Ashcroft K.J.","Beare D.M.","Burford D.C.","Hunt S.E.","Griffiths-Jones S.","Jones M.C.","Keenan S.J.","Oliver K.","Scott C.E.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Andrews D.T.","Ashwell R.I.","Babbage A.K.","Bagguley C.L.","Bailey J.","Bannerjee R.","Barlow K.F.","Bates K.","Beasley H.","Bird C.P.","Bray-Allen S.","Brown A.J.","Brown J.Y.","Burrill W.","Carder C.","Carter N.P.","Chapman J.C.","Clamp M.E.","Clark S.Y.","Clarke G.","Clee C.M.","Clegg S.C.","Cobley V.","Collins J.E.","Corby N.","Coville G.J.","Deloukas P.","Dhami P.","Dunham I.","Dunn M.","Earthrowl M.E.","Ellington A.G.","Faulkner L.","Frankish A.G.","Frankland J.","French L.","Garner P.","Garnett J.","Gilbert J.G.","Gilson C.J.","Ghori J.","Grafham D.V.","Gribble S.M.","Griffiths C.","Hall R.E.","Hammond S.","Harley J.L.","Hart E.A.","Heath P.D.","Howden P.J.","Huckle E.J.","Hunt P.J.","Hunt A.R.","Johnson C.","Johnson D.","Kay M.","Kimberley A.M.","King A.","Laird G.K.","Langford C.J.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Lloyd C.","Loveland J.E.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","McLaren S.J.","McMurray A.","Milne S.","Moore M.J.","Nickerson T.","Palmer S.A.","Pearce A.V.","Peck A.I.","Pelan S.","Phillimore B.","Porter K.M.","Rice C.M.","Searle S.","Sehra H.K.","Shownkeen R.","Skuce C.D.","Smith M.","Steward C.A.","Sycamore N.","Tester J.","Thomas D.W.","Tracey A.","Tromans A.","Tubby B.","Wall M.","Wallis J.M.","West A.P.","Whitehead S.L.","Willey D.L.","Wilming L.","Wray P.W.","Wright M.W.","Young L.","Coulson A.","Durbin R.","Hubbard T.","Sulston J.E.","Beck S.","Bentley D.R.","Rogers J.","Ross M.T."],"citationCrossReferences":[{"database":"PubMed","id":"15057823"},{"database":"DOI","id":"10.1038/nature02379"}],"title":"The DNA sequence and analysis of human chromosome 13.","publicationDate":"2004","journal":"Nature","firstPage":"522","lastPage":"528","volume":"428"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000541563.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000541563.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000541563.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL136300","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL137249","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL161896","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL445223","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"KF455815","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000871504.1","properties":[{"key":"ProteinId","value":"ENSP00000541563.1"},{"key":"GeneId","value":"ENSG00000152767.18"}]},{"database":"Ensembl","id":"ENST00000964193.1","properties":[{"key":"ProteinId","value":"ENSP00000634252.1"},{"key":"GeneId","value":"ENSG00000152767.18"}]},{"database":"HGNC","id":"HGNC:3591","properties":[{"key":"GeneName","value":"FARP1"}]},{"database":"OpenTargets","id":"ENSG00000152767","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000155318","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 13"}]},{"database":"CDD","id":"cd14473","properties":[{"key":"EntryName","value":"FERM_B-lobe"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd13193","properties":[{"key":"EntryName","value":"FERM_C_FARP1-like"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd17189","properties":[{"key":"EntryName","value":"FERM_F1_FARP1"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd01220","properties":[{"key":"EntryName","value":"PH1_FARP1-like"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd13235","properties":[{"key":"EntryName","value":"PH2_FARP1-like"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd00160","properties":[{"key":"EntryName","value":"RhoGEF"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.30.29.30:FF:000002","properties":[{"key":"EntryName","value":"Band 4.1-like protein 5 isoform 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.10.20.90:FF:000040","properties":[{"key":"EntryName","value":"FERM, RhoGEF and pleckstrin domain-containing protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.80.10:FF:000005","properties":[{"key":"EntryName","value":"FERM, RhoGEF and pleckstrin domain-containing protein 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.900.10:FF:000021","properties":[{"key":"EntryName","value":"FERM, RhoGEF and pleckstrin domain-containing protein 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.30.29.30:FF:000046","properties":[{"key":"EntryName","value":"FERM, RhoGEF and pleckstrin domain-containing protein 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.80.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.900.10","properties":[{"key":"EntryName","value":"Dbl homology (DH) domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.10.20.90","properties":[{"key":"EntryName","value":"Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.30.29.30","properties":[{"key":"EntryName","value":"Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"},{"key":"MatchStatus","value":"3"}]},{"database":"InterPro","id":"IPR019749","properties":[{"key":"EntryName","value":"Band_41_domain"}]},{"database":"InterPro","id":"IPR035899","properties":[{"key":"EntryName","value":"DBL_dom_sf"}]},{"database":"InterPro","id":"IPR000219","properties":[{"key":"EntryName","value":"DH_dom"}]},{"database":"InterPro","id":"IPR000798","properties":[{"key":"EntryName","value":"Ez/rad/moesin-like"}]},{"database":"InterPro","id":"IPR014847","properties":[{"key":"EntryName","value":"FA"}]},{"database":"InterPro","id":"IPR041788","properties":[{"key":"EntryName","value":"FARP1/FARP2/FRMD7_FERM_C"}]},{"database":"InterPro","id":"IPR014352","properties":[{"key":"EntryName","value":"FERM/acyl-CoA-bd_prot_sf"}]},{"database":"InterPro","id":"IPR035963","properties":[{"key":"EntryName","value":"FERM_2"}]},{"database":"InterPro","id":"IPR019748","properties":[{"key":"EntryName","value":"FERM_central"}]},{"database":"InterPro","id":"IPR019747","properties":[{"key":"EntryName","value":"FERM_CS"}]},{"database":"InterPro","id":"IPR000299","properties":[{"key":"EntryName","value":"FERM_domain"}]},{"database":"InterPro","id":"IPR018979","properties":[{"key":"EntryName","value":"FERM_N"}]},{"database":"InterPro","id":"IPR018980","properties":[{"key":"EntryName","value":"FERM_PH-like_C"}]},{"database":"InterPro","id":"IPR011993","properties":[{"key":"EntryName","value":"PH-like_dom_sf"}]},{"database":"InterPro","id":"IPR001849","properties":[{"key":"EntryName","value":"PH_domain"}]},{"database":"InterPro","id":"IPR051835","properties":[{"key":"EntryName","value":"RAC1-GEF"}]},{"database":"InterPro","id":"IPR029071","properties":[{"key":"EntryName","value":"Ubiquitin-like_domsf"}]},{"database":"PANTHER","id":"PTHR45858","properties":[{"key":"EntryName","value":"FERM DOMAIN CONTAINING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR45858:SF2","properties":[{"key":"EntryName","value":"FERM, ARHGEF AND PLECKSTRIN DOMAIN-CONTAINING PROTEIN 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08736","properties":[{"key":"EntryName","value":"FA"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF09380","properties":[{"key":"EntryName","value":"FERM_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00373","properties":[{"key":"EntryName","value":"FERM_M"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF09379","properties":[{"key":"EntryName","value":"FERM_N"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00169","properties":[{"key":"EntryName","value":"PH"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF00621","properties":[{"key":"EntryName","value":"RhoGEF"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00935","properties":[{"key":"EntryName","value":"BAND41"}]},{"database":"PRINTS","id":"PR00661","properties":[{"key":"EntryName","value":"ERMFAMILY"}]},{"database":"SMART","id":"SM00295","properties":[{"key":"EntryName","value":"B41"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM01195","properties":[{"key":"EntryName","value":"FA"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM01196","properties":[{"key":"EntryName","value":"FERM_C"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00233","properties":[{"key":"EntryName","value":"PH"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00325","properties":[{"key":"EntryName","value":"RhoGEF"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48065","properties":[{"key":"EntryName","value":"DBL homology domain (DH-domain)"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF50729","properties":[{"key":"EntryName","value":"PH domain-like"},{"key":"MatchStatus","value":"3"}]},{"database":"SUPFAM","id":"SSF47031","properties":[{"key":"EntryName","value":"Second domain of FERM"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54236","properties":[{"key":"EntryName","value":"Ubiquitin-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50010","properties":[{"key":"EntryName","value":"DH_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00660","properties":[{"key":"EntryName","value":"FERM_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50057","properties":[{"key":"EntryName","value":"FERM_3"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50003","properties":[{"key":"EntryName","value":"PH_DOMAIN"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPQRAPGKVLLDAVCNHLNLVEGDYFGLEFPDHKKITVWLDLLKPIVKQIRRPKHVVVKFVVKFFPPDHTQLQEELTRYLFALQVKQDLAQGRLTCNDTSAALLISHIVQSEIGDFDEALDREHLAKNKYIPQQDALEDKIVEFHHNHIGQTPAESDFQLLEIARRLEMYGIRLHPAKDREGTKINLAVANTGILVFQGFTKINAFNWAKVRKLSFKRKRFLIKLRPDANSAYQDTLEFLMASRDFCKSFWKICVEHHAFFRLFEEPKPKPKPVLFSRGSSFRFSGRTQKQVLDYVKEGGHKKVQFERKHSKIHSIRSLASQPTELNSEVLEQSQQSTSLTFGEGAESPGGQSCRRGKEPKVSAGEPGSHPSPAPRRSPAGNKQADGAASAPTEEEEEVVKDRTQQSKPQPPQPSTGSLTGSPHLSELSVNSQGGVAPANVTLSPNLSPDTKQASPLISPLLNDQACPRTDDEDEGRRKRFPTDKAYFIAKEVSTTERTYLKDLEVITSWFQSTVSKEDAMPEALKSLIFPNFEPLHKFHTNFLKEIEQRLALWEGRSNAQIRDYQRIGDVMLKNIQGMKHLAAHLWKHSEALEALENGIKSSRRLENFCRDFELQKVCYLPLNTFLLRPLHRLMHYKQVLERLCKHHPPSHADFRDCRAALAEITEMVAQLHGTMIKMENFQKLHELKKDLIGIDNLVVPGREFIRLGSLSKLSGKGLQQRMFFLFNDVLLYTSRGLTASNQFKVHGQLPLYGMTIEESEDEWGVPHCLTLRGQRQSIIVAASSRSEMEKWVEDIQMAIDLAEKSSSPAPEFLASSPPDNSECGQGSFPMQGSGSWRDSISASKATPSESPDEATAADQESEDDLSASRTSLERQAPHRGNTMVHVCWHRNTSVSMVDFSIAVENQLSGNLLRKFKNSNGWQKLWVVFTNFCLFFYKSHQDNHPLASLPLLGYSLTIPSESENIQKDYVFKLHFKSHVYYFRAESEYTFERWMEVIRSATSSASRPHVLSHKESLVY","length":1073,"molWeight":121462,"crc64":"C9BA9C7CFB0EA800","md5":"DDBA1B36CF1F1B6966851CC685D887FF"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Domain":4,"Region":3,"Compositional bias":4},"uniParcId":"UPI0040325B34"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8RMX6","uniProtkbId":"A0ACI8RMX6_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000541557.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00040395"}],"value":"FERM, ARHGEF and pleckstrin domain-containing protein 1"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00042170"}],"value":"FERM, RhoGEF and pleckstrin domain-containing protein 1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000541557.1"}],"value":"FARP1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00054998"}],"value":"Functions as a guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00064538"}],"value":"Interacts with CADM1. Interacts with RAC1"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004413"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004413"}],"value":"Peripheral membrane protein","id":"SL-9903"},"orientation":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004413"}],"value":"Cytoplasmic side","id":"SL-9910"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004279"}],"value":"Cell projection, dendrite","id":"SL-0283"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004552"}],"value":"Cell projection, dendritic spine","id":"SL-0284"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004486"}],"value":"Cell projection, filopodium","id":"SL-0286"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004514"}],"value":"Cytoplasm, cytosol","id":"SL-0091"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00034102"}],"value":"Synapse, synaptosome","id":"SL-0261"}}]}],"features":[{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":285,"modifier":"EXACT"}},"description":"FERM","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50057"}]},{"type":"Domain","location":{"start":{"value":505,"modifier":"EXACT"},"end":{"value":695,"modifier":"EXACT"}},"description":"DH","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50010"}]},{"type":"Domain","location":{"start":{"value":724,"modifier":"EXACT"},"end":{"value":821,"modifier":"EXACT"}},"description":"PH","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50003"}]},{"type":"Domain","location":{"start":{"value":897,"modifier":"EXACT"},"end":{"value":994,"modifier":"EXACT"}},"description":"PH","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50003"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":38,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":326,"modifier":"EXACT"},"end":{"value":499,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":829,"modifier":"EXACT"},"end":{"value":868,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":338,"modifier":"EXACT"},"end":{"value":361,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":436,"modifier":"EXACT"},"end":{"value":454,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":461,"modifier":"EXACT"},"end":{"value":476,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023273"}],"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022473"}],"id":"KW-0217","category":"Molecular function","name":"Developmental protein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022658"}],"id":"KW-0344","category":"Molecular function","name":"Guanine-nucleotide releasing factor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8RMX6"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8RMX6"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023018"}],"id":"KW-0770","category":"Cellular component","name":"Synapse"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022599"}],"id":"KW-0771","category":"Cellular component","name":"Synaptosome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000541557.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15057823","citationType":"journal article","authors":["Dunham A.","Matthews L.H.","Burton J.","Ashurst J.L.","Howe K.L.","Ashcroft K.J.","Beare D.M.","Burford D.C.","Hunt S.E.","Griffiths-Jones S.","Jones M.C.","Keenan S.J.","Oliver K.","Scott C.E.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Andrews D.T.","Ashwell R.I.","Babbage A.K.","Bagguley C.L.","Bailey J.","Bannerjee R.","Barlow K.F.","Bates K.","Beasley H.","Bird C.P.","Bray-Allen S.","Brown A.J.","Brown J.Y.","Burrill W.","Carder C.","Carter N.P.","Chapman J.C.","Clamp M.E.","Clark S.Y.","Clarke G.","Clee C.M.","Clegg S.C.","Cobley V.","Collins J.E.","Corby N.","Coville G.J.","Deloukas P.","Dhami P.","Dunham I.","Dunn M.","Earthrowl M.E.","Ellington A.G.","Faulkner L.","Frankish A.G.","Frankland J.","French L.","Garner P.","Garnett J.","Gilbert J.G.","Gilson C.J.","Ghori J.","Grafham D.V.","Gribble S.M.","Griffiths C.","Hall R.E.","Hammond S.","Harley J.L.","Hart E.A.","Heath P.D.","Howden P.J.","Huckle E.J.","Hunt P.J.","Hunt A.R.","Johnson C.","Johnson D.","Kay M.","Kimberley A.M.","King A.","Laird G.K.","Langford C.J.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Lloyd C.","Loveland J.E.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","McLaren S.J.","McMurray A.","Milne S.","Moore M.J.","Nickerson T.","Palmer S.A.","Pearce A.V.","Peck A.I.","Pelan S.","Phillimore B.","Porter K.M.","Rice C.M.","Searle S.","Sehra H.K.","Shownkeen R.","Skuce C.D.","Smith M.","Steward C.A.","Sycamore N.","Tester J.","Thomas D.W.","Tracey A.","Tromans A.","Tubby B.","Wall M.","Wallis J.M.","West A.P.","Whitehead S.L.","Willey D.L.","Wilming L.","Wray P.W.","Wright M.W.","Young L.","Coulson A.","Durbin R.","Hubbard T.","Sulston J.E.","Beck S.","Bentley D.R.","Rogers J.","Ross M.T."],"citationCrossReferences":[{"database":"PubMed","id":"15057823"},{"database":"DOI","id":"10.1038/nature02379"}],"title":"The DNA sequence and analysis of human chromosome 13.","publicationDate":"2004","journal":"Nature","firstPage":"522","lastPage":"528","volume":"428"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000541557.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000541557.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000541557.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL136300","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL137249","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL161896","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL445223","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"KF455815","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000871498.1","properties":[{"key":"ProteinId","value":"ENSP00000541557.1"},{"key":"GeneId","value":"ENSG00000152767.18"}]},{"database":"HGNC","id":"HGNC:3591","properties":[{"key":"GeneName","value":"FARP1"}]},{"database":"OpenTargets","id":"ENSG00000152767","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000155318","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 13"}]},{"database":"CDD","id":"cd14473","properties":[{"key":"EntryName","value":"FERM_B-lobe"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd13193","properties":[{"key":"EntryName","value":"FERM_C_FARP1-like"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd01220","properties":[{"key":"EntryName","value":"PH1_FARP1-like"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd13235","properties":[{"key":"EntryName","value":"PH2_FARP1-like"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd00160","properties":[{"key":"EntryName","value":"RhoGEF"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.30.29.30:FF:000002","properties":[{"key":"EntryName","value":"Band 4.1-like protein 5 isoform 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.80.10:FF:000005","properties":[{"key":"EntryName","value":"FERM, RhoGEF and pleckstrin domain-containing protein 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.900.10:FF:000021","properties":[{"key":"EntryName","value":"FERM, RhoGEF and pleckstrin domain-containing protein 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.30.29.30:FF:000046","properties":[{"key":"EntryName","value":"FERM, RhoGEF and pleckstrin domain-containing protein 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.80.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.900.10","properties":[{"key":"EntryName","value":"Dbl homology (DH) domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.30.29.30","properties":[{"key":"EntryName","value":"Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"},{"key":"MatchStatus","value":"3"}]},{"database":"InterPro","id":"IPR019749","properties":[{"key":"EntryName","value":"Band_41_domain"}]},{"database":"InterPro","id":"IPR035899","properties":[{"key":"EntryName","value":"DBL_dom_sf"}]},{"database":"InterPro","id":"IPR000219","properties":[{"key":"EntryName","value":"DH_dom"}]},{"database":"InterPro","id":"IPR014847","properties":[{"key":"EntryName","value":"FA"}]},{"database":"InterPro","id":"IPR041788","properties":[{"key":"EntryName","value":"FARP1/FARP2/FRMD7_FERM_C"}]},{"database":"InterPro","id":"IPR014352","properties":[{"key":"EntryName","value":"FERM/acyl-CoA-bd_prot_sf"}]},{"database":"InterPro","id":"IPR035963","properties":[{"key":"EntryName","value":"FERM_2"}]},{"database":"InterPro","id":"IPR019748","properties":[{"key":"EntryName","value":"FERM_central"}]},{"database":"InterPro","id":"IPR019747","properties":[{"key":"EntryName","value":"FERM_CS"}]},{"database":"InterPro","id":"IPR000299","properties":[{"key":"EntryName","value":"FERM_domain"}]},{"database":"InterPro","id":"IPR018980","properties":[{"key":"EntryName","value":"FERM_PH-like_C"}]},{"database":"InterPro","id":"IPR011993","properties":[{"key":"EntryName","value":"PH-like_dom_sf"}]},{"database":"InterPro","id":"IPR001849","properties":[{"key":"EntryName","value":"PH_domain"}]},{"database":"InterPro","id":"IPR051835","properties":[{"key":"EntryName","value":"RAC1-GEF"}]},{"database":"PANTHER","id":"PTHR45858","properties":[{"key":"EntryName","value":"FERM DOMAIN CONTAINING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR45858:SF2","properties":[{"key":"EntryName","value":"FERM, ARHGEF AND PLECKSTRIN DOMAIN-CONTAINING PROTEIN 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08736","properties":[{"key":"EntryName","value":"FA"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF09380","properties":[{"key":"EntryName","value":"FERM_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00373","properties":[{"key":"EntryName","value":"FERM_M"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00169","properties":[{"key":"EntryName","value":"PH"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF00621","properties":[{"key":"EntryName","value":"RhoGEF"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00935","properties":[{"key":"EntryName","value":"BAND41"}]},{"database":"SMART","id":"SM00295","properties":[{"key":"EntryName","value":"B41"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM01195","properties":[{"key":"EntryName","value":"FA"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM01196","properties":[{"key":"EntryName","value":"FERM_C"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00233","properties":[{"key":"EntryName","value":"PH"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00325","properties":[{"key":"EntryName","value":"RhoGEF"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48065","properties":[{"key":"EntryName","value":"DBL homology domain (DH-domain)"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF50729","properties":[{"key":"EntryName","value":"PH domain-like"},{"key":"MatchStatus","value":"3"}]},{"database":"SUPFAM","id":"SSF47031","properties":[{"key":"EntryName","value":"Second domain of FERM"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50010","properties":[{"key":"EntryName","value":"DH_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00660","properties":[{"key":"EntryName","value":"FERM_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50057","properties":[{"key":"EntryName","value":"FERM_3"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50003","properties":[{"key":"EntryName","value":"PH_DOMAIN"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPVWLDLLKPIVKQIRRPKHVVVKFVVKFFPPDHTQLQEELTRYLFALQVKQDLAQGRLTCNDTSAALLISHIVQSEIGDFDEALDREHLAKNKYIPQQDALEDKIVEFHHNHIGQTPAESDFQLLEIARRLEMYGIRLHPAKDREGTKINLAVANTGILVFQGFTKINAFNWAKVRKLSFKRKRFLIKLRPDANSAYQDTLEFLMASRDFCKSFWKICVEHHAFFRLFEEPKPKPKPVLFSRGSSFRFSGRTQKQVLDYVKEGGHKKVQFERKHSKIHSIRSLASQPTELNSEVLEQSQQSTSLTFGEGAESPGGQSCRRGKEPKVSAGEPGSHPSPAPRRSPAGNKQADGAASAPTEEEEEVVKDRTQQSKPQPPQPSTGSLTGSPHLSELSVNSQGGVAPANVTLSPNLSPDTKQASPLISPLLNDQACPRTDDEDEGRRKRFPTDKAYFIAKEVSTTERTYLKDLEVITSWFQSTVSKEDAMPEALKSLIFPNFEPLHKFHTNFLKEIEQRLALWEGRSNAQIRDYQRIGDVMLKNIQGMKHLAAHLWKHSEALEALENGIKSSRRLENFCRDFELQKVCYLPLNTFLLRPLHRLMHYKQVLERLCKHHPPSHADFRDCRAALAEITEMVAQLHGTMIKMENFQKLHELKKDLIGIDNLVVPGREFIRLGSLSKLSGKGLQQRMFFLFNDVLLYTSRGLTASNQFKVHGQLPLYGMTIEESEDEWGVPHCLTLRGQRQSIIVAASSRSEMEKWVEDIQMAIDLAEKSSSPAPEFLASSPPDNKSPDEATAADQESEDDLSASRTSLERQAPHRGNTMVHVCWHRNTSVSMVDFSIAVENQLSGNLLRKFKNSNGWQKLWVVFTNFCLFFYKSHQDNHPLASLPLLGYSLTIPSESENIQKDYVFKLHFKSHVYYFRAESEYTFERWMEVIRSATSSASRPHVLSHKESLVY","length":1010,"molWeight":114712,"crc64":"FB7EBEEEF5758529","md5":"F65B9B2E8C409AA617E3DD066EA24B17"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Domain":4,"Region":3,"Compositional bias":3},"uniParcId":"UPI0040324AE2"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8PR96","uniProtkbId":"A0ACI8PR96_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000541558.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00040395"}],"value":"FERM, ARHGEF and pleckstrin domain-containing protein 1"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00042170"}],"value":"FERM, RhoGEF and pleckstrin domain-containing protein 1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000541558.1"}],"value":"FARP1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00054998"}],"value":"Functions as a guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00064538"}],"value":"Interacts with CADM1. Interacts with RAC1"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004413"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004413"}],"value":"Peripheral membrane protein","id":"SL-9903"},"orientation":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004413"}],"value":"Cytoplasmic side","id":"SL-9910"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004279"}],"value":"Cell projection, dendrite","id":"SL-0283"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004552"}],"value":"Cell projection, dendritic spine","id":"SL-0284"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004486"}],"value":"Cell projection, filopodium","id":"SL-0286"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004514"}],"value":"Cytoplasm, cytosol","id":"SL-0091"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00034102"}],"value":"Synapse, synaptosome","id":"SL-0261"}}]}],"features":[{"type":"Domain","location":{"start":{"value":40,"modifier":"EXACT"},"end":{"value":320,"modifier":"EXACT"}},"description":"FERM","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50057"}]},{"type":"Domain","location":{"start":{"value":504,"modifier":"EXACT"},"end":{"value":694,"modifier":"EXACT"}},"description":"DH","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50010"}]},{"type":"Domain","location":{"start":{"value":723,"modifier":"EXACT"},"end":{"value":820,"modifier":"EXACT"}},"description":"PH","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50003"}]},{"type":"Domain","location":{"start":{"value":896,"modifier":"EXACT"},"end":{"value":993,"modifier":"EXACT"}},"description":"PH","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50003"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":37,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":370,"modifier":"EXACT"},"end":{"value":498,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":828,"modifier":"EXACT"},"end":{"value":867,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":373,"modifier":"EXACT"},"end":{"value":396,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":438,"modifier":"EXACT"},"end":{"value":453,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":460,"modifier":"EXACT"},"end":{"value":475,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023273"}],"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022473"}],"id":"KW-0217","category":"Molecular function","name":"Developmental protein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022658"}],"id":"KW-0344","category":"Molecular function","name":"Guanine-nucleotide releasing factor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8PR96"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8PR96"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023018"}],"id":"KW-0770","category":"Cellular component","name":"Synapse"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022599"}],"id":"KW-0771","category":"Cellular component","name":"Synaptosome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000541558.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15057823","citationType":"journal article","authors":["Dunham A.","Matthews L.H.","Burton J.","Ashurst J.L.","Howe K.L.","Ashcroft K.J.","Beare D.M.","Burford D.C.","Hunt S.E.","Griffiths-Jones S.","Jones M.C.","Keenan S.J.","Oliver K.","Scott C.E.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Andrews D.T.","Ashwell R.I.","Babbage A.K.","Bagguley C.L.","Bailey J.","Bannerjee R.","Barlow K.F.","Bates K.","Beasley H.","Bird C.P.","Bray-Allen S.","Brown A.J.","Brown J.Y.","Burrill W.","Carder C.","Carter N.P.","Chapman J.C.","Clamp M.E.","Clark S.Y.","Clarke G.","Clee C.M.","Clegg S.C.","Cobley V.","Collins J.E.","Corby N.","Coville G.J.","Deloukas P.","Dhami P.","Dunham I.","Dunn M.","Earthrowl M.E.","Ellington A.G.","Faulkner L.","Frankish A.G.","Frankland J.","French L.","Garner P.","Garnett J.","Gilbert J.G.","Gilson C.J.","Ghori J.","Grafham D.V.","Gribble S.M.","Griffiths C.","Hall R.E.","Hammond S.","Harley J.L.","Hart E.A.","Heath P.D.","Howden P.J.","Huckle E.J.","Hunt P.J.","Hunt A.R.","Johnson C.","Johnson D.","Kay M.","Kimberley A.M.","King A.","Laird G.K.","Langford C.J.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Lloyd C.","Loveland J.E.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","McLaren S.J.","McMurray A.","Milne S.","Moore M.J.","Nickerson T.","Palmer S.A.","Pearce A.V.","Peck A.I.","Pelan S.","Phillimore B.","Porter K.M.","Rice C.M.","Searle S.","Sehra H.K.","Shownkeen R.","Skuce C.D.","Smith M.","Steward C.A.","Sycamore N.","Tester J.","Thomas D.W.","Tracey A.","Tromans A.","Tubby B.","Wall M.","Wallis J.M.","West A.P.","Whitehead S.L.","Willey D.L.","Wilming L.","Wray P.W.","Wright M.W.","Young L.","Coulson A.","Durbin R.","Hubbard T.","Sulston J.E.","Beck S.","Bentley D.R.","Rogers J.","Ross M.T."],"citationCrossReferences":[{"database":"PubMed","id":"15057823"},{"database":"DOI","id":"10.1038/nature02379"}],"title":"The DNA sequence and analysis of human chromosome 13.","publicationDate":"2004","journal":"Nature","firstPage":"522","lastPage":"528","volume":"428"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000541558.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000541558.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000541558.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL136300","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL137249","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL161896","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL445223","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"KF455815","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000871499.1","properties":[{"key":"ProteinId","value":"ENSP00000541558.1"},{"key":"GeneId","value":"ENSG00000152767.18"}]},{"database":"HGNC","id":"HGNC:3591","properties":[{"key":"GeneName","value":"FARP1"}]},{"database":"OpenTargets","id":"ENSG00000152767","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000155318","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 13"}]},{"database":"CDD","id":"cd14473","properties":[{"key":"EntryName","value":"FERM_B-lobe"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd13193","properties":[{"key":"EntryName","value":"FERM_C_FARP1-like"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd01220","properties":[{"key":"EntryName","value":"PH1_FARP1-like"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd13235","properties":[{"key":"EntryName","value":"PH2_FARP1-like"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd00160","properties":[{"key":"EntryName","value":"RhoGEF"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.30.29.30:FF:000002","properties":[{"key":"EntryName","value":"Band 4.1-like protein 5 isoform 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.10.20.90:FF:000040","properties":[{"key":"EntryName","value":"FERM, RhoGEF and pleckstrin domain-containing protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.80.10:FF:000005","properties":[{"key":"EntryName","value":"FERM, RhoGEF and pleckstrin domain-containing protein 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.900.10:FF:000021","properties":[{"key":"EntryName","value":"FERM, RhoGEF and pleckstrin domain-containing protein 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.30.29.30:FF:000046","properties":[{"key":"EntryName","value":"FERM, RhoGEF and pleckstrin domain-containing protein 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.80.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.900.10","properties":[{"key":"EntryName","value":"Dbl homology (DH) domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.10.20.90","properties":[{"key":"EntryName","value":"Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.30.29.30","properties":[{"key":"EntryName","value":"Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"},{"key":"MatchStatus","value":"3"}]},{"database":"InterPro","id":"IPR019749","properties":[{"key":"EntryName","value":"Band_41_domain"}]},{"database":"InterPro","id":"IPR035899","properties":[{"key":"EntryName","value":"DBL_dom_sf"}]},{"database":"InterPro","id":"IPR000219","properties":[{"key":"EntryName","value":"DH_dom"}]},{"database":"InterPro","id":"IPR000798","properties":[{"key":"EntryName","value":"Ez/rad/moesin-like"}]},{"database":"InterPro","id":"IPR014847","properties":[{"key":"EntryName","value":"FA"}]},{"database":"InterPro","id":"IPR041788","properties":[{"key":"EntryName","value":"FARP1/FARP2/FRMD7_FERM_C"}]},{"database":"InterPro","id":"IPR014352","properties":[{"key":"EntryName","value":"FERM/acyl-CoA-bd_prot_sf"}]},{"database":"InterPro","id":"IPR035963","properties":[{"key":"EntryName","value":"FERM_2"}]},{"database":"InterPro","id":"IPR019748","properties":[{"key":"EntryName","value":"FERM_central"}]},{"database":"InterPro","id":"IPR019747","properties":[{"key":"EntryName","value":"FERM_CS"}]},{"database":"InterPro","id":"IPR000299","properties":[{"key":"EntryName","value":"FERM_domain"}]},{"database":"InterPro","id":"IPR018979","properties":[{"key":"EntryName","value":"FERM_N"}]},{"database":"InterPro","id":"IPR018980","properties":[{"key":"EntryName","value":"FERM_PH-like_C"}]},{"database":"InterPro","id":"IPR011993","properties":[{"key":"EntryName","value":"PH-like_dom_sf"}]},{"database":"InterPro","id":"IPR001849","properties":[{"key":"EntryName","value":"PH_domain"}]},{"database":"InterPro","id":"IPR051835","properties":[{"key":"EntryName","value":"RAC1-GEF"}]},{"database":"InterPro","id":"IPR029071","properties":[{"key":"EntryName","value":"Ubiquitin-like_domsf"}]},{"database":"PANTHER","id":"PTHR45858","properties":[{"key":"EntryName","value":"FERM DOMAIN CONTAINING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR45858:SF2","properties":[{"key":"EntryName","value":"FERM, ARHGEF AND PLECKSTRIN DOMAIN-CONTAINING PROTEIN 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08736","properties":[{"key":"EntryName","value":"FA"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF09380","properties":[{"key":"EntryName","value":"FERM_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00373","properties":[{"key":"EntryName","value":"FERM_M"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF09379","properties":[{"key":"EntryName","value":"FERM_N"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00169","properties":[{"key":"EntryName","value":"PH"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF00621","properties":[{"key":"EntryName","value":"RhoGEF"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00935","properties":[{"key":"EntryName","value":"BAND41"}]},{"database":"PRINTS","id":"PR00661","properties":[{"key":"EntryName","value":"ERMFAMILY"}]},{"database":"SMART","id":"SM00295","properties":[{"key":"EntryName","value":"B41"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM01195","properties":[{"key":"EntryName","value":"FA"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM01196","properties":[{"key":"EntryName","value":"FERM_C"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00233","properties":[{"key":"EntryName","value":"PH"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00325","properties":[{"key":"EntryName","value":"RhoGEF"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48065","properties":[{"key":"EntryName","value":"DBL homology domain (DH-domain)"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF50729","properties":[{"key":"EntryName","value":"PH domain-like"},{"key":"MatchStatus","value":"3"}]},{"database":"SUPFAM","id":"SSF47031","properties":[{"key":"EntryName","value":"Second domain of FERM"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54236","properties":[{"key":"EntryName","value":"Ubiquitin-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50010","properties":[{"key":"EntryName","value":"DH_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00660","properties":[{"key":"EntryName","value":"FERM_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50057","properties":[{"key":"EntryName","value":"FERM_3"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50003","properties":[{"key":"EntryName","value":"PH_DOMAIN"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPQRAPGKVLLDAVCNHLNLVEGDYFGLEFPDHKKITVWLDLLKPIVKQIRRPKHVVVKFVVKFFPPDHTQLQEELTRYLFALQVKQDLAQGRLTCNDTSAALLISHIVQSEIGDFDEALDREHLAKNKYIPQQDALEDKIVEFHHNHIGQTPAESDFQLLEIARRLEMYGIRLHPAKDREGTKINLAVANTGILVFQGFTKINAFNWAKVRKLSFKRKRFLIKLRPDANSAYQDTLEFLMASRDFCKSFWKICVEHHAFFRLFEEPKPKPKPVLFSRGSSFRFSGRTQKQVLDYVKEGGHKKVQFERKHSKIHSIRSLASQPTELNSEVLEQSQQSTSLTFGEGAESPGGQSCRRGKEPKVSAGEPGSHPSPAPRRSPAGSLTGSPHLSELSVNSQGGVAPANVTLSPNLSPDTKQASPLISPLLNDQACPRTDDEDEGRRKRFPTDKAYFIAKEVSTTERTYLKDLEVITSWFQSTVSKEDAMPEALKSLIFPNFEPLHKFHTNFLKEIEQRLALWEGRSNAQIRDYQRIGDVMLKNIQGMKHLAAHLWKHSEALEALENGIKSSRRLENFCRDFELQKVCYLPLNTFLLRPLHRLMHYKQVLERLCKHHPPSHADFRDCRAALAEITEMVAQLHGTMIKMENFQKLHELKKDLIGIDNLVVPGREFIRLGSLSKLSGKGLQQRMFFLFNDVLLYTSRGLTASNQFKVHGQLPLYGMTIEESEDEWGVPHCLTLRGQRQSIIVAASSRSEMEKWVEDIQMAIDLAEKSSSPAPEFLASSPPDNKSPDEATAADQESEDDLSASRTSLERQAPHRGNTMVHVCWHRNTSVSMVDFSIAVENQLSGNLLRKFKNSNGWQKLWVVFTNFCLFFYKSHQDNHPLASLPLLGYSLTIPSESENIQKDYVFKLHFKSHVYYFRAESEYTFERWMEVIRSATSSASRPHVLSHKESLVY","length":1009,"molWeight":114815,"crc64":"066963FE9F5300B2","md5":"B122698D6F4D638911E8DEA12D884C93"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Domain":4,"Region":3,"Compositional bias":3},"uniParcId":"UPI004031927D"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8RW14","uniProtkbId":"A0ACI8RW14_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000541560.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00040395"}],"value":"FERM, ARHGEF and pleckstrin domain-containing protein 1"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00042170"}],"value":"FERM, RhoGEF and pleckstrin domain-containing protein 1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000541560.1"}],"value":"FARP1"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004413"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004413"}],"value":"Peripheral membrane protein","id":"SL-9903"},"orientation":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004413"}],"value":"Cytoplasmic side","id":"SL-9910"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004279"}],"value":"Cell projection, dendrite","id":"SL-0283"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004552"}],"value":"Cell projection, dendritic spine","id":"SL-0284"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004486"}],"value":"Cell projection, filopodium","id":"SL-0286"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004514"}],"value":"Cytoplasm, cytosol","id":"SL-0091"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00034102"}],"value":"Synapse, synaptosome","id":"SL-0261"}}]}],"features":[{"type":"Domain","location":{"start":{"value":40,"modifier":"EXACT"},"end":{"value":320,"modifier":"EXACT"}},"description":"FERM","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50057"}]},{"type":"Domain","location":{"start":{"value":540,"modifier":"EXACT"},"end":{"value":629,"modifier":"EXACT"}},"description":"DH","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50010"}]},{"type":"Domain","location":{"start":{"value":636,"modifier":"EXACT"},"end":{"value":733,"modifier":"EXACT"}},"description":"PH","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50003"}]},{"type":"Domain","location":{"start":{"value":809,"modifier":"EXACT"},"end":{"value":906,"modifier":"EXACT"}},"description":"PH","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50003"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":37,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":361,"modifier":"EXACT"},"end":{"value":534,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":741,"modifier":"EXACT"},"end":{"value":780,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":373,"modifier":"EXACT"},"end":{"value":396,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":471,"modifier":"EXACT"},"end":{"value":489,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":496,"modifier":"EXACT"},"end":{"value":511,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023273"}],"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022473"}],"id":"KW-0217","category":"Molecular function","name":"Developmental protein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022658"}],"id":"KW-0344","category":"Molecular function","name":"Guanine-nucleotide releasing factor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8RW14"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8RW14"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023018"}],"id":"KW-0770","category":"Cellular component","name":"Synapse"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022599"}],"id":"KW-0771","category":"Cellular component","name":"Synaptosome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000541560.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15057823","citationType":"journal article","authors":["Dunham A.","Matthews L.H.","Burton J.","Ashurst J.L.","Howe K.L.","Ashcroft K.J.","Beare D.M.","Burford D.C.","Hunt S.E.","Griffiths-Jones S.","Jones M.C.","Keenan S.J.","Oliver K.","Scott C.E.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Andrews D.T.","Ashwell R.I.","Babbage A.K.","Bagguley C.L.","Bailey J.","Bannerjee R.","Barlow K.F.","Bates K.","Beasley H.","Bird C.P.","Bray-Allen S.","Brown A.J.","Brown J.Y.","Burrill W.","Carder C.","Carter N.P.","Chapman J.C.","Clamp M.E.","Clark S.Y.","Clarke G.","Clee C.M.","Clegg S.C.","Cobley V.","Collins J.E.","Corby N.","Coville G.J.","Deloukas P.","Dhami P.","Dunham I.","Dunn M.","Earthrowl M.E.","Ellington A.G.","Faulkner L.","Frankish A.G.","Frankland J.","French L.","Garner P.","Garnett J.","Gilbert J.G.","Gilson C.J.","Ghori J.","Grafham D.V.","Gribble S.M.","Griffiths C.","Hall R.E.","Hammond S.","Harley J.L.","Hart E.A.","Heath P.D.","Howden P.J.","Huckle E.J.","Hunt P.J.","Hunt A.R.","Johnson C.","Johnson D.","Kay M.","Kimberley A.M.","King A.","Laird G.K.","Langford C.J.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Lloyd C.","Loveland J.E.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","McLaren S.J.","McMurray A.","Milne S.","Moore M.J.","Nickerson T.","Palmer S.A.","Pearce A.V.","Peck A.I.","Pelan S.","Phillimore B.","Porter K.M.","Rice C.M.","Searle S.","Sehra H.K.","Shownkeen R.","Skuce C.D.","Smith M.","Steward C.A.","Sycamore N.","Tester J.","Thomas D.W.","Tracey A.","Tromans A.","Tubby B.","Wall M.","Wallis J.M.","West A.P.","Whitehead S.L.","Willey D.L.","Wilming L.","Wray P.W.","Wright M.W.","Young L.","Coulson A.","Durbin R.","Hubbard T.","Sulston J.E.","Beck S.","Bentley D.R.","Rogers J.","Ross M.T."],"citationCrossReferences":[{"database":"PubMed","id":"15057823"},{"database":"DOI","id":"10.1038/nature02379"}],"title":"The DNA sequence and analysis of human chromosome 13.","publicationDate":"2004","journal":"Nature","firstPage":"522","lastPage":"528","volume":"428"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000541560.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000541560.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000541560.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL136300","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL137249","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL161896","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL445223","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"KF455815","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000871501.1","properties":[{"key":"ProteinId","value":"ENSP00000541560.1"},{"key":"GeneId","value":"ENSG00000152767.18"}]},{"database":"HGNC","id":"HGNC:3591","properties":[{"key":"GeneName","value":"FARP1"}]},{"database":"OpenTargets","id":"ENSG00000152767","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000155318","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 13"}]},{"database":"CDD","id":"cd14473","properties":[{"key":"EntryName","value":"FERM_B-lobe"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd13193","properties":[{"key":"EntryName","value":"FERM_C_FARP1-like"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd17189","properties":[{"key":"EntryName","value":"FERM_F1_FARP1"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd01220","properties":[{"key":"EntryName","value":"PH1_FARP1-like"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd13235","properties":[{"key":"EntryName","value":"PH2_FARP1-like"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.30.29.30:FF:000002","properties":[{"key":"EntryName","value":"Band 4.1-like protein 5 isoform 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.10.20.90:FF:000040","properties":[{"key":"EntryName","value":"FERM, RhoGEF and pleckstrin domain-containing protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.80.10:FF:000005","properties":[{"key":"EntryName","value":"FERM, RhoGEF and pleckstrin domain-containing protein 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.30.29.30:FF:000046","properties":[{"key":"EntryName","value":"FERM, RhoGEF and pleckstrin domain-containing protein 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.80.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.10.20.90","properties":[{"key":"EntryName","value":"Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.30.29.30","properties":[{"key":"EntryName","value":"Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"},{"key":"MatchStatus","value":"3"}]},{"database":"InterPro","id":"IPR019749","properties":[{"key":"EntryName","value":"Band_41_domain"}]},{"database":"InterPro","id":"IPR035899","properties":[{"key":"EntryName","value":"DBL_dom_sf"}]},{"database":"InterPro","id":"IPR000219","properties":[{"key":"EntryName","value":"DH_dom"}]},{"database":"InterPro","id":"IPR000798","properties":[{"key":"EntryName","value":"Ez/rad/moesin-like"}]},{"database":"InterPro","id":"IPR014847","properties":[{"key":"EntryName","value":"FA"}]},{"database":"InterPro","id":"IPR041788","properties":[{"key":"EntryName","value":"FARP1/FARP2/FRMD7_FERM_C"}]},{"database":"InterPro","id":"IPR014352","properties":[{"key":"EntryName","value":"FERM/acyl-CoA-bd_prot_sf"}]},{"database":"InterPro","id":"IPR035963","properties":[{"key":"EntryName","value":"FERM_2"}]},{"database":"InterPro","id":"IPR019748","properties":[{"key":"EntryName","value":"FERM_central"}]},{"database":"InterPro","id":"IPR019747","properties":[{"key":"EntryName","value":"FERM_CS"}]},{"database":"InterPro","id":"IPR000299","properties":[{"key":"EntryName","value":"FERM_domain"}]},{"database":"InterPro","id":"IPR018979","properties":[{"key":"EntryName","value":"FERM_N"}]},{"database":"InterPro","id":"IPR018980","properties":[{"key":"EntryName","value":"FERM_PH-like_C"}]},{"database":"InterPro","id":"IPR011993","properties":[{"key":"EntryName","value":"PH-like_dom_sf"}]},{"database":"InterPro","id":"IPR001849","properties":[{"key":"EntryName","value":"PH_domain"}]},{"database":"InterPro","id":"IPR051835","properties":[{"key":"EntryName","value":"RAC1-GEF"}]},{"database":"InterPro","id":"IPR029071","properties":[{"key":"EntryName","value":"Ubiquitin-like_domsf"}]},{"database":"PANTHER","id":"PTHR45858","properties":[{"key":"EntryName","value":"FERM DOMAIN CONTAINING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR45858:SF2","properties":[{"key":"EntryName","value":"FERM, ARHGEF AND PLECKSTRIN DOMAIN-CONTAINING PROTEIN 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08736","properties":[{"key":"EntryName","value":"FA"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF09380","properties":[{"key":"EntryName","value":"FERM_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00373","properties":[{"key":"EntryName","value":"FERM_M"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF09379","properties":[{"key":"EntryName","value":"FERM_N"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00169","properties":[{"key":"EntryName","value":"PH"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF00621","properties":[{"key":"EntryName","value":"RhoGEF"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00935","properties":[{"key":"EntryName","value":"BAND41"}]},{"database":"PRINTS","id":"PR00661","properties":[{"key":"EntryName","value":"ERMFAMILY"}]},{"database":"SMART","id":"SM00295","properties":[{"key":"EntryName","value":"B41"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM01195","properties":[{"key":"EntryName","value":"FA"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM01196","properties":[{"key":"EntryName","value":"FERM_C"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00233","properties":[{"key":"EntryName","value":"PH"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00325","properties":[{"key":"EntryName","value":"RhoGEF"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48065","properties":[{"key":"EntryName","value":"DBL homology domain (DH-domain)"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF50729","properties":[{"key":"EntryName","value":"PH domain-like"},{"key":"MatchStatus","value":"3"}]},{"database":"SUPFAM","id":"SSF47031","properties":[{"key":"EntryName","value":"Second domain of FERM"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54236","properties":[{"key":"EntryName","value":"Ubiquitin-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50010","properties":[{"key":"EntryName","value":"DH_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00660","properties":[{"key":"EntryName","value":"FERM_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50057","properties":[{"key":"EntryName","value":"FERM_3"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50003","properties":[{"key":"EntryName","value":"PH_DOMAIN"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPQRAPGKVLLDAVCNHLNLVEGDYFGLEFPDHKKITVWLDLLKPIVKQIRRPKHVVVKFVVKFFPPDHTQLQEELTRYLFALQVKQDLAQGRLTCNDTSAALLISHIVQSEIGDFDEALDREHLAKNKYIPQQDALEDKIVEFHHNHIGQTPAESDFQLLEIARRLEMYGIRLHPAKDREGTKINLAVANTGILVFQGFTKINAFNWAKVRKLSFKRKRFLIKLRPDANSAYQDTLEFLMASRDFCKSFWKICVEHHAFFRLFEEPKPKPKPVLFSRGSSFRFSGRTQKQVLDYVKEGGHKKVQFERKHSKIHSIRSLASQPTELNSEVLEQSQQSTSLTFGEGAESPGGQSCRRGKEPKVSAGEPGSHPSPAPRRSPAGNKQADGAASAPTEEEEEVVKDRTQQSKPQPPQPSTGSLTGSPHLSELSVNSQGGVAPANVTLSPNLSPDTKQASPLISPLLNDQACPRTDDEDEGRRKRFPTDKAYFIAKEVSTTERTYLKDLEVITSWFQSTVSKEDAMPEALKSLIFPNFEPLHKFHTNFLKEIEQRLALWEGRSNAQIRDYQRIGDVMLKNIQGMKEFIRLGSLSKLSGKGLQQRMFFLFNDVLLYTSRGLTASNQFKVHGQLPLYGMTIEESEDEWGVPHCLTLRGQRQSIIVAASSRSEMEKWVEDIQMAIDLAEKSSSPAPEFLASSPPDNKSPDEATAADQESEDDLSASRTSLERQAPHRGNTMVHVCWHRNTSVSMVDFSIAVENQLSGNLLRKFKNSNGWQKLWVVFTNFCLFFYKSHQDNHPLASLPLLGYSLTIPSESENIQKDYVFKLHFKSHVYYFRAESEYTFERWMEVIRSATSSASRPHVLSHKESLVY","length":922,"molWeight":104237,"crc64":"DD7BDB16ED12157E","md5":"835C0EF200E570FB6BD11A8850203D61"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Domain":4,"Region":3,"Compositional bias":3},"uniParcId":"UPI0040321B01"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8T4E5","uniProtkbId":"A0ACI8T4E5_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000592643.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00040395"}],"value":"FERM, ARHGEF and pleckstrin domain-containing protein 1"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00042170"}],"value":"FERM, RhoGEF and pleckstrin domain-containing protein 1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000592643.1"}],"value":"FARP1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00054998"}],"value":"Functions as a guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00064538"}],"value":"Interacts with CADM1. Interacts with RAC1"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004413"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004413"}],"value":"Peripheral membrane protein","id":"SL-9903"},"orientation":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004413"}],"value":"Cytoplasmic side","id":"SL-9910"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004279"}],"value":"Cell projection, dendrite","id":"SL-0283"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004552"}],"value":"Cell projection, dendritic spine","id":"SL-0284"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004486"}],"value":"Cell projection, filopodium","id":"SL-0286"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004514"}],"value":"Cytoplasm, cytosol","id":"SL-0091"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00034102"}],"value":"Synapse, synaptosome","id":"SL-0261"}}]}],"features":[{"type":"Domain","location":{"start":{"value":40,"modifier":"EXACT"},"end":{"value":320,"modifier":"EXACT"}},"description":"FERM","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50057"}]},{"type":"Domain","location":{"start":{"value":540,"modifier":"EXACT"},"end":{"value":727,"modifier":"EXACT"}},"description":"DH","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50010"}]},{"type":"Domain","location":{"start":{"value":756,"modifier":"EXACT"},"end":{"value":853,"modifier":"EXACT"}},"description":"PH","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50003"}]},{"type":"Domain","location":{"start":{"value":929,"modifier":"EXACT"},"end":{"value":1026,"modifier":"EXACT"}},"description":"PH","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50003"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":37,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":361,"modifier":"EXACT"},"end":{"value":534,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":861,"modifier":"EXACT"},"end":{"value":900,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":373,"modifier":"EXACT"},"end":{"value":396,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":471,"modifier":"EXACT"},"end":{"value":489,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":496,"modifier":"EXACT"},"end":{"value":511,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023273"}],"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022473"}],"id":"KW-0217","category":"Molecular function","name":"Developmental protein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022658"}],"id":"KW-0344","category":"Molecular function","name":"Guanine-nucleotide releasing factor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8T4E5"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8T4E5"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023018"}],"id":"KW-0770","category":"Cellular component","name":"Synapse"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022599"}],"id":"KW-0771","category":"Cellular component","name":"Synaptosome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000592643.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15057823","citationType":"journal article","authors":["Dunham A.","Matthews L.H.","Burton J.","Ashurst J.L.","Howe K.L.","Ashcroft K.J.","Beare D.M.","Burford D.C.","Hunt S.E.","Griffiths-Jones S.","Jones M.C.","Keenan S.J.","Oliver K.","Scott C.E.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Andrews D.T.","Ashwell R.I.","Babbage A.K.","Bagguley C.L.","Bailey J.","Bannerjee R.","Barlow K.F.","Bates K.","Beasley H.","Bird C.P.","Bray-Allen S.","Brown A.J.","Brown J.Y.","Burrill W.","Carder C.","Carter N.P.","Chapman J.C.","Clamp M.E.","Clark S.Y.","Clarke G.","Clee C.M.","Clegg S.C.","Cobley V.","Collins J.E.","Corby N.","Coville G.J.","Deloukas P.","Dhami P.","Dunham I.","Dunn M.","Earthrowl M.E.","Ellington A.G.","Faulkner L.","Frankish A.G.","Frankland J.","French L.","Garner P.","Garnett J.","Gilbert J.G.","Gilson C.J.","Ghori J.","Grafham D.V.","Gribble S.M.","Griffiths C.","Hall R.E.","Hammond S.","Harley J.L.","Hart E.A.","Heath P.D.","Howden P.J.","Huckle E.J.","Hunt P.J.","Hunt A.R.","Johnson C.","Johnson D.","Kay M.","Kimberley A.M.","King A.","Laird G.K.","Langford C.J.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Lloyd C.","Loveland J.E.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","McLaren S.J.","McMurray A.","Milne S.","Moore M.J.","Nickerson T.","Palmer S.A.","Pearce A.V.","Peck A.I.","Pelan S.","Phillimore B.","Porter K.M.","Rice C.M.","Searle S.","Sehra H.K.","Shownkeen R.","Skuce C.D.","Smith M.","Steward C.A.","Sycamore N.","Tester J.","Thomas D.W.","Tracey A.","Tromans A.","Tubby B.","Wall M.","Wallis J.M.","West A.P.","Whitehead S.L.","Willey D.L.","Wilming L.","Wray P.W.","Wright M.W.","Young L.","Coulson A.","Durbin R.","Hubbard T.","Sulston J.E.","Beck S.","Bentley D.R.","Rogers J.","Ross M.T."],"citationCrossReferences":[{"database":"PubMed","id":"15057823"},{"database":"DOI","id":"10.1038/nature02379"}],"title":"The DNA sequence and analysis of human chromosome 13.","publicationDate":"2004","journal":"Nature","firstPage":"522","lastPage":"528","volume":"428"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000592643.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000592643.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000592643.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL136300","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL137249","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL161896","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL445223","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"KF455815","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000922584.1","properties":[{"key":"ProteinId","value":"ENSP00000592643.1"},{"key":"GeneId","value":"ENSG00000152767.18"}]},{"database":"HGNC","id":"HGNC:3591","properties":[{"key":"GeneName","value":"FARP1"}]},{"database":"OpenTargets","id":"ENSG00000152767","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000155318","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 13"}]},{"database":"CDD","id":"cd14473","properties":[{"key":"EntryName","value":"FERM_B-lobe"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd13193","properties":[{"key":"EntryName","value":"FERM_C_FARP1-like"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd01220","properties":[{"key":"EntryName","value":"PH1_FARP1-like"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd13235","properties":[{"key":"EntryName","value":"PH2_FARP1-like"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd00160","properties":[{"key":"EntryName","value":"RhoGEF"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.30.29.30:FF:000002","properties":[{"key":"EntryName","value":"Band 4.1-like protein 5 isoform 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.10.20.90:FF:000040","properties":[{"key":"EntryName","value":"FERM, RhoGEF and pleckstrin domain-containing protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.80.10:FF:000005","properties":[{"key":"EntryName","value":"FERM, RhoGEF and pleckstrin domain-containing protein 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.900.10:FF:000021","properties":[{"key":"EntryName","value":"FERM, RhoGEF and pleckstrin domain-containing protein 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.30.29.30:FF:000046","properties":[{"key":"EntryName","value":"FERM, RhoGEF and pleckstrin domain-containing protein 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.80.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.900.10","properties":[{"key":"EntryName","value":"Dbl homology (DH) domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.10.20.90","properties":[{"key":"EntryName","value":"Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.30.29.30","properties":[{"key":"EntryName","value":"Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"},{"key":"MatchStatus","value":"3"}]},{"database":"InterPro","id":"IPR019749","properties":[{"key":"EntryName","value":"Band_41_domain"}]},{"database":"InterPro","id":"IPR035899","properties":[{"key":"EntryName","value":"DBL_dom_sf"}]},{"database":"InterPro","id":"IPR000219","properties":[{"key":"EntryName","value":"DH_dom"}]},{"database":"InterPro","id":"IPR000798","properties":[{"key":"EntryName","value":"Ez/rad/moesin-like"}]},{"database":"InterPro","id":"IPR014847","properties":[{"key":"EntryName","value":"FA"}]},{"database":"InterPro","id":"IPR041788","properties":[{"key":"EntryName","value":"FARP1/FARP2/FRMD7_FERM_C"}]},{"database":"InterPro","id":"IPR014352","properties":[{"key":"EntryName","value":"FERM/acyl-CoA-bd_prot_sf"}]},{"database":"InterPro","id":"IPR035963","properties":[{"key":"EntryName","value":"FERM_2"}]},{"database":"InterPro","id":"IPR019748","properties":[{"key":"EntryName","value":"FERM_central"}]},{"database":"InterPro","id":"IPR019747","properties":[{"key":"EntryName","value":"FERM_CS"}]},{"database":"InterPro","id":"IPR000299","properties":[{"key":"EntryName","value":"FERM_domain"}]},{"database":"InterPro","id":"IPR018979","properties":[{"key":"EntryName","value":"FERM_N"}]},{"database":"InterPro","id":"IPR018980","properties":[{"key":"EntryName","value":"FERM_PH-like_C"}]},{"database":"InterPro","id":"IPR011993","properties":[{"key":"EntryName","value":"PH-like_dom_sf"}]},{"database":"InterPro","id":"IPR001849","properties":[{"key":"EntryName","value":"PH_domain"}]},{"database":"InterPro","id":"IPR051835","properties":[{"key":"EntryName","value":"RAC1-GEF"}]},{"database":"InterPro","id":"IPR029071","properties":[{"key":"EntryName","value":"Ubiquitin-like_domsf"}]},{"database":"PANTHER","id":"PTHR45858","properties":[{"key":"EntryName","value":"FERM DOMAIN CONTAINING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR45858:SF2","properties":[{"key":"EntryName","value":"FERM, ARHGEF AND PLECKSTRIN DOMAIN-CONTAINING PROTEIN 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08736","properties":[{"key":"EntryName","value":"FA"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF09380","properties":[{"key":"EntryName","value":"FERM_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00373","properties":[{"key":"EntryName","value":"FERM_M"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF09379","properties":[{"key":"EntryName","value":"FERM_N"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00169","properties":[{"key":"EntryName","value":"PH"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF00621","properties":[{"key":"EntryName","value":"RhoGEF"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00935","properties":[{"key":"EntryName","value":"BAND41"}]},{"database":"PRINTS","id":"PR00661","properties":[{"key":"EntryName","value":"ERMFAMILY"}]},{"database":"SMART","id":"SM00295","properties":[{"key":"EntryName","value":"B41"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM01195","properties":[{"key":"EntryName","value":"FA"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM01196","properties":[{"key":"EntryName","value":"FERM_C"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00233","properties":[{"key":"EntryName","value":"PH"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00325","properties":[{"key":"EntryName","value":"RhoGEF"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48065","properties":[{"key":"EntryName","value":"DBL homology domain (DH-domain)"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF50729","properties":[{"key":"EntryName","value":"PH domain-like"},{"key":"MatchStatus","value":"3"}]},{"database":"SUPFAM","id":"SSF47031","properties":[{"key":"EntryName","value":"Second domain of FERM"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54236","properties":[{"key":"EntryName","value":"Ubiquitin-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50010","properties":[{"key":"EntryName","value":"DH_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00660","properties":[{"key":"EntryName","value":"FERM_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50057","properties":[{"key":"EntryName","value":"FERM_3"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50003","properties":[{"key":"EntryName","value":"PH_DOMAIN"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPQRAPGKVLLDAVCNHLNLVEGDYFGLEFPDHKKITVWLDLLKPIVKQIRRPKHVVVKFVVKFFPPDHTQLQEELTRYLFALQVKQDLAQGRLTCNDTSAALLISHIVQSEIGDFDEALDREHLAKNKYIPQQDALEDKIVEFHHNHIGQTPAESDFQLLEIARRLEMYGIRLHPAKDREGTKINLAVANTGILVFQGFTKINAFNWAKVRKLSFKRKRFLIKLRPDANSAYQDTLEFLMASRDFCKSFWKICVEHHAFFRLFEEPKPKPKPVLFSRGSSFRFSGRTQKQVLDYVKEGGHKKVQFERKHSKIHSIRSLASQPTELNSEVLEQSQQSTSLTFGEGAESPGGQSCRRGKEPKVSAGEPGSHPSPAPRRSPAGNKQADGAASAPTEEEEEVVKDRTQQSKPQPPQPSTGSLTGSPHLSELSVNSQGGVAPANVTLSPNLSPDTKQASPLISPLLNDQACPRTDDEDEGRRKRFPTDKAYFIAKEVSTTERTYLKDLEVITSSTVSKEDAMPEALKSLIFPNFEPLHKFHTNFLKEIEQRLALWEGRSNAQIRDYQRIGDVMLKNIQGMKHLAAHLWKHSEALEALENGIKSSRRLENFCRDFELQKVCYLPLNTFLLRPLHRLMHYKQVLERLCKHHPPSHADFRDCRAALAEITEMVAQLHGTMIKMENFQKLHELKKDLIGIDNLVVPGREFIRLGSLSKLSGKGLQQRMFFLFNDVLLYTSRGLTASNQFKVHGQLPLYGMTIEESEDEWGVPHCLTLRGQRQSIIVAASSRSEMEKWVEDIQMAIDLAEKSSSPAPEFLASSPPDNKSPDEATAADQESEDDLSASRTSLERQAPHRGNTMVHVCWHRNTSVSMVDFSIAVENQLSGNLLRKFKNSNGWQKLWVVFTNFCLFFYKSHQDNHPLASLPLLGYSLTIPSESENIQKDYVFKLHFKSHVYYFRAESEYTFERWMEVIRSATSSASRPHVLSHKESLVY","length":1042,"molWeight":118171,"crc64":"E10B0530A5BB5F07","md5":"04E95C2E1E38AC4BAE01B5B67B103F8C"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Domain":4,"Region":3,"Compositional bias":3},"uniParcId":"UPI0040315BA8"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8T4F2","uniProtkbId":"A0ACI8T4F2_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000592642.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00040395"}],"value":"FERM, ARHGEF and pleckstrin domain-containing protein 1"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00042170"}],"value":"FERM, RhoGEF and pleckstrin domain-containing protein 1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000592642.1"}],"value":"FARP1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00054998"}],"value":"Functions as a guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00064538"}],"value":"Interacts with CADM1. Interacts with RAC1"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004413"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004413"}],"value":"Peripheral membrane protein","id":"SL-9903"},"orientation":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004413"}],"value":"Cytoplasmic side","id":"SL-9910"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004279"}],"value":"Cell projection, dendrite","id":"SL-0283"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004552"}],"value":"Cell projection, dendritic spine","id":"SL-0284"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004486"}],"value":"Cell projection, filopodium","id":"SL-0286"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004514"}],"value":"Cytoplasm, cytosol","id":"SL-0091"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00034102"}],"value":"Synapse, synaptosome","id":"SL-0261"}}]}],"features":[{"type":"Domain","location":{"start":{"value":40,"modifier":"EXACT"},"end":{"value":320,"modifier":"EXACT"}},"description":"FERM","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50057"}]},{"type":"Domain","location":{"start":{"value":530,"modifier":"EXACT"},"end":{"value":720,"modifier":"EXACT"}},"description":"DH","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50010"}]},{"type":"Domain","location":{"start":{"value":749,"modifier":"EXACT"},"end":{"value":846,"modifier":"EXACT"}},"description":"PH","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50003"}]},{"type":"Domain","location":{"start":{"value":922,"modifier":"EXACT"},"end":{"value":1019,"modifier":"EXACT"}},"description":"PH","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50003"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":37,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":375,"modifier":"EXACT"},"end":{"value":441,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":854,"modifier":"EXACT"},"end":{"value":893,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":375,"modifier":"EXACT"},"end":{"value":396,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023273"}],"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022473"}],"id":"KW-0217","category":"Molecular function","name":"Developmental protein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022658"}],"id":"KW-0344","category":"Molecular function","name":"Guanine-nucleotide releasing factor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8T4F2"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8T4F2"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023018"}],"id":"KW-0770","category":"Cellular component","name":"Synapse"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022599"}],"id":"KW-0771","category":"Cellular component","name":"Synaptosome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000592642.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15057823","citationType":"journal article","authors":["Dunham A.","Matthews L.H.","Burton J.","Ashurst J.L.","Howe K.L.","Ashcroft K.J.","Beare D.M.","Burford D.C.","Hunt S.E.","Griffiths-Jones S.","Jones M.C.","Keenan S.J.","Oliver K.","Scott C.E.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Andrews D.T.","Ashwell R.I.","Babbage A.K.","Bagguley C.L.","Bailey J.","Bannerjee R.","Barlow K.F.","Bates K.","Beasley H.","Bird C.P.","Bray-Allen S.","Brown A.J.","Brown J.Y.","Burrill W.","Carder C.","Carter N.P.","Chapman J.C.","Clamp M.E.","Clark S.Y.","Clarke G.","Clee C.M.","Clegg S.C.","Cobley V.","Collins J.E.","Corby N.","Coville G.J.","Deloukas P.","Dhami P.","Dunham I.","Dunn M.","Earthrowl M.E.","Ellington A.G.","Faulkner L.","Frankish A.G.","Frankland J.","French L.","Garner P.","Garnett J.","Gilbert J.G.","Gilson C.J.","Ghori J.","Grafham D.V.","Gribble S.M.","Griffiths C.","Hall R.E.","Hammond S.","Harley J.L.","Hart E.A.","Heath P.D.","Howden P.J.","Huckle E.J.","Hunt P.J.","Hunt A.R.","Johnson C.","Johnson D.","Kay M.","Kimberley A.M.","King A.","Laird G.K.","Langford C.J.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Lloyd C.","Loveland J.E.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","McLaren S.J.","McMurray A.","Milne S.","Moore M.J.","Nickerson T.","Palmer S.A.","Pearce A.V.","Peck A.I.","Pelan S.","Phillimore B.","Porter K.M.","Rice C.M.","Searle S.","Sehra H.K.","Shownkeen R.","Skuce C.D.","Smith M.","Steward C.A.","Sycamore N.","Tester J.","Thomas D.W.","Tracey A.","Tromans A.","Tubby B.","Wall M.","Wallis J.M.","West A.P.","Whitehead S.L.","Willey D.L.","Wilming L.","Wray P.W.","Wright M.W.","Young L.","Coulson A.","Durbin R.","Hubbard T.","Sulston J.E.","Beck S.","Bentley D.R.","Rogers J.","Ross M.T."],"citationCrossReferences":[{"database":"PubMed","id":"15057823"},{"database":"DOI","id":"10.1038/nature02379"}],"title":"The DNA sequence and analysis of human chromosome 13.","publicationDate":"2004","journal":"Nature","firstPage":"522","lastPage":"528","volume":"428"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000592642.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000592642.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000592642.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL136300","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL137249","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL161896","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL445223","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"KF455815","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000922583.1","properties":[{"key":"ProteinId","value":"ENSP00000592642.1"},{"key":"GeneId","value":"ENSG00000152767.18"}]},{"database":"HGNC","id":"HGNC:3591","properties":[{"key":"GeneName","value":"FARP1"}]},{"database":"OpenTargets","id":"ENSG00000152767","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000155318","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 13"}]},{"database":"CDD","id":"cd14473","properties":[{"key":"EntryName","value":"FERM_B-lobe"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd13193","properties":[{"key":"EntryName","value":"FERM_C_FARP1-like"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd01220","properties":[{"key":"EntryName","value":"PH1_FARP1-like"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd13235","properties":[{"key":"EntryName","value":"PH2_FARP1-like"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd00160","properties":[{"key":"EntryName","value":"RhoGEF"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.30.29.30:FF:000002","properties":[{"key":"EntryName","value":"Band 4.1-like protein 5 isoform 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.10.20.90:FF:000040","properties":[{"key":"EntryName","value":"FERM, RhoGEF and pleckstrin domain-containing protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.80.10:FF:000005","properties":[{"key":"EntryName","value":"FERM, RhoGEF and pleckstrin domain-containing protein 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.900.10:FF:000021","properties":[{"key":"EntryName","value":"FERM, RhoGEF and pleckstrin domain-containing protein 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.30.29.30:FF:000046","properties":[{"key":"EntryName","value":"FERM, RhoGEF and pleckstrin domain-containing protein 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.80.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.900.10","properties":[{"key":"EntryName","value":"Dbl homology (DH) domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.10.20.90","properties":[{"key":"EntryName","value":"Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.30.29.30","properties":[{"key":"EntryName","value":"Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"},{"key":"MatchStatus","value":"3"}]},{"database":"InterPro","id":"IPR019749","properties":[{"key":"EntryName","value":"Band_41_domain"}]},{"database":"InterPro","id":"IPR035899","properties":[{"key":"EntryName","value":"DBL_dom_sf"}]},{"database":"InterPro","id":"IPR000219","properties":[{"key":"EntryName","value":"DH_dom"}]},{"database":"InterPro","id":"IPR000798","properties":[{"key":"EntryName","value":"Ez/rad/moesin-like"}]},{"database":"InterPro","id":"IPR014847","properties":[{"key":"EntryName","value":"FA"}]},{"database":"InterPro","id":"IPR041788","properties":[{"key":"EntryName","value":"FARP1/FARP2/FRMD7_FERM_C"}]},{"database":"InterPro","id":"IPR014352","properties":[{"key":"EntryName","value":"FERM/acyl-CoA-bd_prot_sf"}]},{"database":"InterPro","id":"IPR035963","properties":[{"key":"EntryName","value":"FERM_2"}]},{"database":"InterPro","id":"IPR019748","properties":[{"key":"EntryName","value":"FERM_central"}]},{"database":"InterPro","id":"IPR019747","properties":[{"key":"EntryName","value":"FERM_CS"}]},{"database":"InterPro","id":"IPR000299","properties":[{"key":"EntryName","value":"FERM_domain"}]},{"database":"InterPro","id":"IPR018979","properties":[{"key":"EntryName","value":"FERM_N"}]},{"database":"InterPro","id":"IPR018980","properties":[{"key":"EntryName","value":"FERM_PH-like_C"}]},{"database":"InterPro","id":"IPR011993","properties":[{"key":"EntryName","value":"PH-like_dom_sf"}]},{"database":"InterPro","id":"IPR001849","properties":[{"key":"EntryName","value":"PH_domain"}]},{"database":"InterPro","id":"IPR051835","properties":[{"key":"EntryName","value":"RAC1-GEF"}]},{"database":"InterPro","id":"IPR029071","properties":[{"key":"EntryName","value":"Ubiquitin-like_domsf"}]},{"database":"PANTHER","id":"PTHR45858","properties":[{"key":"EntryName","value":"FERM DOMAIN CONTAINING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR45858:SF2","properties":[{"key":"EntryName","value":"FERM, ARHGEF AND PLECKSTRIN DOMAIN-CONTAINING PROTEIN 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08736","properties":[{"key":"EntryName","value":"FA"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF09380","properties":[{"key":"EntryName","value":"FERM_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00373","properties":[{"key":"EntryName","value":"FERM_M"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF09379","properties":[{"key":"EntryName","value":"FERM_N"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00169","properties":[{"key":"EntryName","value":"PH"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF00621","properties":[{"key":"EntryName","value":"RhoGEF"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00935","properties":[{"key":"EntryName","value":"BAND41"}]},{"database":"PRINTS","id":"PR00661","properties":[{"key":"EntryName","value":"ERMFAMILY"}]},{"database":"SMART","id":"SM00295","properties":[{"key":"EntryName","value":"B41"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM01195","properties":[{"key":"EntryName","value":"FA"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM01196","properties":[{"key":"EntryName","value":"FERM_C"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00233","properties":[{"key":"EntryName","value":"PH"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00325","properties":[{"key":"EntryName","value":"RhoGEF"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48065","properties":[{"key":"EntryName","value":"DBL homology domain (DH-domain)"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF50729","properties":[{"key":"EntryName","value":"PH domain-like"},{"key":"MatchStatus","value":"3"}]},{"database":"SUPFAM","id":"SSF47031","properties":[{"key":"EntryName","value":"Second domain of FERM"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54236","properties":[{"key":"EntryName","value":"Ubiquitin-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50010","properties":[{"key":"EntryName","value":"DH_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00660","properties":[{"key":"EntryName","value":"FERM_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50057","properties":[{"key":"EntryName","value":"FERM_3"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50003","properties":[{"key":"EntryName","value":"PH_DOMAIN"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPQRAPGKVLLDAVCNHLNLVEGDYFGLEFPDHKKITVWLDLLKPIVKQIRRPKHVVVKFVVKFFPPDHTQLQEELTRYLFALQVKQDLAQGRLTCNDTSAALLISHIVQSEIGDFDEALDREHLAKNKYIPQQDALEDKIVEFHHNHIGQTPAESDFQLLEIARRLEMYGIRLHPAKDREGTKINLAVANTGILVFQGFTKINAFNWAKVRKLSFKRKRFLIKLRPDANSAYQDTLEFLMASRDFCKSFWKICVEHHAFFRLFEEPKPKPKPVLFSRGSSFRFSGRTQKQVLDYVKEGGHKKVQFERKHSKIHSIRSLASQPTELNSEVLEQSQQSTSLTFGEGAESPGGQSCRRGKEPKVSAGEPGSHPSPAPRRSPAGTGSKKHTYITLNNLRYQEEDHTANMGSLTGSPHLSELSVNSQGGVAPANVTLSPNLSPDTKQASPLISPLLNDQACPRTDDEDEGRRKRFPTDKAYFIAKEVSTTERTYLKDLEVITSWFQSTVSKEDAMPEALKSLIFPNFEPLHKFHTNFLKEIEQRLALWEGRSNAQIRDYQRIGDVMLKNIQGMKHLAAHLWKHSEALEALENGIKSSRRLENFCRDFELQKVCYLPLNTFLLRPLHRLMHYKQVLERLCKHHPPSHADFRDCRAALAEITEMVAQLHGTMIKMENFQKLHELKKDLIGIDNLVVPGREFIRLGSLSKLSGKGLQQRMFFLFNDVLLYTSRGLTASNQFKVHGQLPLYGMTIEESEDEWGVPHCLTLRGQRQSIIVAASSRSEMEKWVEDIQMAIDLAEKSSSPAPEFLASSPPDNKSPDEATAADQESEDDLSASRTSLERQAPHRGNTMVHVCWHRNTSVSMVDFSIAVENQLSGNLLRKFKNSNGWQKLWVVFTNFCLFFYKSHQDNHPLASLPLLGYSLTIPSESENIQKDYVFKLHFKSHVYYFRAESEYTFERWMEVIRSATSSASRPHVLSHKESLVY","length":1035,"molWeight":117819,"crc64":"7336395CDF1A9DC6","md5":"53D6BB9E0DADD01503572D0824F291EF"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Domain":4,"Region":3,"Compositional bias":1},"uniParcId":"UPI004031E858"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"H0Y783","uniProtkbId":"H0Y783_HUMAN","entryAudit":{"firstPublicDate":"2012-02-22","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2013-04-03","entryVersion":88,"sequenceVersion":2},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000410930.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000410930.2"}],"value":"FERM, ARH/RhoGEF and pleckstrin domain protein 1"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000410930.2"}],"value":"FARP1"}}],"features":[{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":95,"modifier":"EXACT"}},"description":"DH","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50010"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000410930.2"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"H0Y783"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"H0Y783"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000410930.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15057823","citationType":"journal article","authors":["Dunham A.","Matthews L.H.","Burton J.","Ashurst J.L.","Howe K.L.","Ashcroft K.J.","Beare D.M.","Burford D.C.","Hunt S.E.","Griffiths-Jones S.","Jones M.C.","Keenan S.J.","Oliver K.","Scott C.E.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Andrews D.T.","Ashwell R.I.","Babbage A.K.","Bagguley C.L.","Bailey J.","Bannerjee R.","Barlow K.F.","Bates K.","Beasley H.","Bird C.P.","Bray-Allen S.","Brown A.J.","Brown J.Y.","Burrill W.","Carder C.","Carter N.P.","Chapman J.C.","Clamp M.E.","Clark S.Y.","Clarke G.","Clee C.M.","Clegg S.C.","Cobley V.","Collins J.E.","Corby N.","Coville G.J.","Deloukas P.","Dhami P.","Dunham I.","Dunn M.","Earthrowl M.E.","Ellington A.G.","Faulkner L.","Frankish A.G.","Frankland J.","French L.","Garner P.","Garnett J.","Gilbert J.G.","Gilson C.J.","Ghori J.","Grafham D.V.","Gribble S.M.","Griffiths C.","Hall R.E.","Hammond S.","Harley J.L.","Hart E.A.","Heath P.D.","Howden P.J.","Huckle E.J.","Hunt P.J.","Hunt A.R.","Johnson C.","Johnson D.","Kay M.","Kimberley A.M.","King A.","Laird G.K.","Langford C.J.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Lloyd C.","Loveland J.E.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","McLaren S.J.","McMurray A.","Milne S.","Moore M.J.","Nickerson T.","Palmer S.A.","Pearce A.V.","Peck A.I.","Pelan S.","Phillimore B.","Porter K.M.","Rice C.M.","Searle S.","Sehra H.K.","Shownkeen R.","Skuce C.D.","Smith M.","Steward C.A.","Sycamore N.","Tester J.","Thomas D.W.","Tracey A.","Tromans A.","Tubby B.","Wall M.","Wallis J.M.","West A.P.","Whitehead S.L.","Willey D.L.","Wilming L.","Wray P.W.","Wright M.W.","Young L.","Coulson A.","Durbin R.","Hubbard T.","Sulston J.E.","Beck S.","Bentley D.R.","Rogers J.","Ross M.T."],"citationCrossReferences":[{"database":"PubMed","id":"15057823"},{"database":"DOI","id":"10.1038/nature02379"}],"title":"The DNA sequence and analysis of human chromosome 13.","publicationDate":"2004","journal":"Nature","firstPage":"522","lastPage":"528","volume":"428"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000410930.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000410930.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Burckstummer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"21269460"}]},{"referenceNumber":5,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000410930.2"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL136300","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL137249","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL161896","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL445223","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"KF455815","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"H0Y783","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"H0Y783","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"H0Y783","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"35379","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"619","properties":[{"key":"antibodies","value":"214 antibodies from 21 providers"}]},{"database":"Ensembl","id":"ENST00000423063.2","properties":[{"key":"ProteinId","value":"ENSP00000410930.2"},{"key":"GeneId","value":"ENSG00000152767.18"}]},{"database":"UCSC","id":"uc058xxs.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:3591","properties":[{"key":"GeneName","value":"FARP1"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000152767","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000155318","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_1285899_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"9990815at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"FARP1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 13"}]},{"database":"Bgee","id":"ENSG00000152767","properties":[{"key":"ExpressionPatterns","value":"Expressed in renal medulla and 204 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"H0Y783","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005085","properties":[{"key":"GoTerm","value":"F:guanyl-nucleotide exchange factor activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"1.20.900.10","properties":[{"key":"EntryName","value":"Dbl homology (DH) domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR035899","properties":[{"key":"EntryName","value":"DBL_dom_sf"}]},{"database":"InterPro","id":"IPR000219","properties":[{"key":"EntryName","value":"DH_dom"}]},{"database":"InterPro","id":"IPR051835","properties":[{"key":"EntryName","value":"RAC1-GEF"}]},{"database":"PANTHER","id":"PTHR45858","properties":[{"key":"EntryName","value":"FERM DOMAIN CONTAINING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR45858:SF2","properties":[{"key":"EntryName","value":"FERM, ARHGEF AND PLECKSTRIN DOMAIN-CONTAINING PROTEIN 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00621","properties":[{"key":"EntryName","value":"RhoGEF"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48065","properties":[{"key":"EntryName","value":"DBL homology domain (DH-domain)"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50010","properties":[{"key":"EntryName","value":"DH_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"HLAAHLWKHSEALEALENGIKSSRRLENFCRDFELQKVCYLPLNTFLLRPLHRLMHYKQVLERLCKHHPPSHADFRDCRAALAEITEMVAQLHGTMIKMENFQKLHELKKDLIGIDNLVVPGRVSSSGLTMHCAGSRKEASEGLTFEPFEERPLQSKMSSFHPPGRQLEKHNSVVSSESLCSEEIKQSSDLIFCFFSLRGDSLLYLFPYHIPQKI","length":215,"molWeight":24750,"crc64":"C20FA0E3288348F0","md5":"3E5CAFD194CC87FBC704CDF370711313"},"extraAttributes":{"countByFeatureType":{"Domain":1,"Non-terminal residue":1},"uniParcId":"UPI0002A471DD"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"M0QYB0","uniProtkbId":"M0QYB0_HUMAN","entryAudit":{"firstPublicDate":"2013-04-03","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2013-04-03","entryVersion":86,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000469712.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000469712.1"}],"value":"FERM, ARH/RhoGEF and pleckstrin domain protein 1"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000469712.1"}],"value":"FARP1"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004552"}],"value":"Cell projection, dendritic spine","id":"SL-0284"}}]}],"features":[{"type":"Domain","location":{"start":{"value":40,"modifier":"EXACT"},"end":{"value":203,"modifier":"EXACT"}},"description":"FERM","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50057"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":37,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":203,"modifier":"EXACT"},"end":{"value":203,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000469712.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"M0QYB0"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"M0QYB0"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023018"}],"id":"KW-0770","category":"Cellular component","name":"Synapse"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000469712.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15057823","citationType":"journal article","authors":["Dunham A.","Matthews L.H.","Burton J.","Ashurst J.L.","Howe K.L.","Ashcroft K.J.","Beare D.M.","Burford D.C.","Hunt S.E.","Griffiths-Jones S.","Jones M.C.","Keenan S.J.","Oliver K.","Scott C.E.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Andrews D.T.","Ashwell R.I.","Babbage A.K.","Bagguley C.L.","Bailey J.","Bannerjee R.","Barlow K.F.","Bates K.","Beasley H.","Bird C.P.","Bray-Allen S.","Brown A.J.","Brown J.Y.","Burrill W.","Carder C.","Carter N.P.","Chapman J.C.","Clamp M.E.","Clark S.Y.","Clarke G.","Clee C.M.","Clegg S.C.","Cobley V.","Collins J.E.","Corby N.","Coville G.J.","Deloukas P.","Dhami P.","Dunham I.","Dunn M.","Earthrowl M.E.","Ellington A.G.","Faulkner L.","Frankish A.G.","Frankland J.","French L.","Garner P.","Garnett J.","Gilbert J.G.","Gilson C.J.","Ghori J.","Grafham D.V.","Gribble S.M.","Griffiths C.","Hall R.E.","Hammond S.","Harley J.L.","Hart E.A.","Heath P.D.","Howden P.J.","Huckle E.J.","Hunt P.J.","Hunt A.R.","Johnson C.","Johnson D.","Kay M.","Kimberley A.M.","King A.","Laird G.K.","Langford C.J.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Lloyd C.","Loveland J.E.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","McLaren S.J.","McMurray A.","Milne S.","Moore M.J.","Nickerson T.","Palmer S.A.","Pearce A.V.","Peck A.I.","Pelan S.","Phillimore B.","Porter K.M.","Rice C.M.","Searle S.","Sehra H.K.","Shownkeen R.","Skuce C.D.","Smith M.","Steward C.A.","Sycamore N.","Tester J.","Thomas D.W.","Tracey A.","Tromans A.","Tubby B.","Wall M.","Wallis J.M.","West A.P.","Whitehead S.L.","Willey D.L.","Wilming L.","Wray P.W.","Wright M.W.","Young L.","Coulson A.","Durbin R.","Hubbard T.","Sulston J.E.","Beck S.","Bentley D.R.","Rogers J.","Ross M.T."],"citationCrossReferences":[{"database":"PubMed","id":"15057823"},{"database":"DOI","id":"10.1038/nature02379"}],"title":"The DNA sequence and analysis of human chromosome 13.","publicationDate":"2004","journal":"Nature","firstPage":"522","lastPage":"528","volume":"428"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000469712.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000469712.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"17081983","citationType":"journal article","authors":["Olsen J.V.","Blagoev B.","Gnad F.","Macek B.","Kumar C.","Mortensen P.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"17081983"},{"database":"DOI","id":"10.1016/j.cell.2006.09.026"}],"title":"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.","publicationDate":"2006","journal":"Cell","firstPage":"635","lastPage":"648","volume":"127"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"17081983"}]},{"referenceNumber":5,"citation":{"id":"18669648","citationType":"journal article","authors":["Dephoure N.","Zhou C.","Villen J.","Beausoleil S.A.","Bakalarski C.E.","Elledge S.J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"18669648"},{"database":"DOI","id":"10.1073/pnas.0805139105"}],"title":"A quantitative atlas of mitotic phosphorylation.","publicationDate":"2008","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10762","lastPage":"10767","volume":"105"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"18669648"}]},{"referenceNumber":6,"citation":{"id":"19413330","citationType":"journal article","authors":["Gauci S.","Helbig A.O.","Slijper M.","Krijgsveld J.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"19413330"},{"database":"DOI","id":"10.1021/ac9004309"}],"title":"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.","publicationDate":"2009","journal":"Anal. Chem.","firstPage":"4493","lastPage":"4501","volume":"81"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"19413330"}]},{"referenceNumber":7,"citation":{"id":"20068231","citationType":"journal article","authors":["Olsen J.V.","Vermeulen M.","Santamaria A.","Kumar C.","Miller M.L.","Jensen L.J.","Gnad F.","Cox J.","Jensen T.S.","Nigg E.A.","Brunak S.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"20068231"},{"database":"DOI","id":"10.1126/scisignal.2000475"}],"title":"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.","publicationDate":"2010","journal":"Sci. Signal.","firstPage":"RA3","lastPage":"RA3","volume":"3"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"20068231"}]},{"referenceNumber":8,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Burckstummer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"21269460"}]},{"referenceNumber":9,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"23186163"}]},{"referenceNumber":10,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"24275569"}]},{"referenceNumber":11,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000469712.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL136300","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL137249","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL161896","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL445223","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"KF455815","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"M0QYB0","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"M0QYB0","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"M0QYB0","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"619","properties":[{"key":"antibodies","value":"214 antibodies from 21 providers"}]},{"database":"Ensembl","id":"ENST00000598389.5","properties":[{"key":"ProteinId","value":"ENSP00000469712.1"},{"key":"GeneId","value":"ENSG00000152767.18"}]},{"database":"UCSC","id":"uc058xwl.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:3591","properties":[{"key":"GeneName","value":"FARP1"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000152767","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000155318","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_003623_1_6_1","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"PHCLTLC","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9990815at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"FARP1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 13"}]},{"database":"Bgee","id":"ENSG00000152767","properties":[{"key":"ExpressionPatterns","value":"Expressed in renal medulla and 204 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"M0QYB0","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0043197","properties":[{"key":"GoTerm","value":"C:dendritic spine"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0008092","properties":[{"key":"GoTerm","value":"F:cytoskeletal protein binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd14473","properties":[{"key":"EntryName","value":"FERM_B-lobe"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.10.20.90:FF:000040","properties":[{"key":"EntryName","value":"FERM, RhoGEF and pleckstrin domain-containing protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.80.10:FF:000005","properties":[{"key":"EntryName","value":"FERM, RhoGEF and pleckstrin domain-containing protein 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.80.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.10.20.90","properties":[{"key":"EntryName","value":"Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR019749","properties":[{"key":"EntryName","value":"Band_41_domain"}]},{"database":"InterPro","id":"IPR000798","properties":[{"key":"EntryName","value":"Ez/rad/moesin-like"}]},{"database":"InterPro","id":"IPR014352","properties":[{"key":"EntryName","value":"FERM/acyl-CoA-bd_prot_sf"}]},{"database":"InterPro","id":"IPR035963","properties":[{"key":"EntryName","value":"FERM_2"}]},{"database":"InterPro","id":"IPR019748","properties":[{"key":"EntryName","value":"FERM_central"}]},{"database":"InterPro","id":"IPR019747","properties":[{"key":"EntryName","value":"FERM_CS"}]},{"database":"InterPro","id":"IPR000299","properties":[{"key":"EntryName","value":"FERM_domain"}]},{"database":"InterPro","id":"IPR018979","properties":[{"key":"EntryName","value":"FERM_N"}]},{"database":"InterPro","id":"IPR051835","properties":[{"key":"EntryName","value":"RAC1-GEF"}]},{"database":"InterPro","id":"IPR029071","properties":[{"key":"EntryName","value":"Ubiquitin-like_domsf"}]},{"database":"PANTHER","id":"PTHR45858","properties":[{"key":"EntryName","value":"FERM DOMAIN CONTAINING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR45858:SF2","properties":[{"key":"EntryName","value":"FERM, ARHGEF AND PLECKSTRIN DOMAIN-CONTAINING PROTEIN 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00373","properties":[{"key":"EntryName","value":"FERM_M"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF09379","properties":[{"key":"EntryName","value":"FERM_N"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00935","properties":[{"key":"EntryName","value":"BAND41"}]},{"database":"PRINTS","id":"PR00661","properties":[{"key":"EntryName","value":"ERMFAMILY"}]},{"database":"SMART","id":"SM00295","properties":[{"key":"EntryName","value":"B41"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF47031","properties":[{"key":"EntryName","value":"Second domain of FERM"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54236","properties":[{"key":"EntryName","value":"Ubiquitin-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00660","properties":[{"key":"EntryName","value":"FERM_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50057","properties":[{"key":"EntryName","value":"FERM_3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPQRAPGKVLLDAVCNHLNLVEGDYFGLEFPDHKKITVWLDLLKPIVKQIRRPKHVVVKFVVKFFPPDHTQLQEELTRYLFALQVKQDLAQGRLTCNDTSAALLISHIVQSEIGDFDEALDREHLAKNKYIPQQDALEDKIVEFHHNH","length":203,"molWeight":22996,"crc64":"5BB94031278F6085","md5":"DA7B2BF8257EA7CB3BBFAFD7CB5C395D"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Domain":1,"Region":1,"Non-terminal residue":1},"uniParcId":"UPI0002A476DF"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"M0R262","uniProtkbId":"M0R262_HUMAN","entryAudit":{"firstPublicDate":"2013-04-03","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":77,"sequenceVersion":3},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000472346.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000472346.1"}],"value":"FERM, ARH/RhoGEF and pleckstrin domain protein 1"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000472346.1"}],"value":"FARP1"}}],"features":[{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":171,"modifier":"EXACT"}},"description":"FERM","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50057"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000472346.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"M0R262"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"M0R262"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000472346.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15057823","citationType":"journal article","authors":["Dunham A.","Matthews L.H.","Burton J.","Ashurst J.L.","Howe K.L.","Ashcroft K.J.","Beare D.M.","Burford D.C.","Hunt S.E.","Griffiths-Jones S.","Jones M.C.","Keenan S.J.","Oliver K.","Scott C.E.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Andrews D.T.","Ashwell R.I.","Babbage A.K.","Bagguley C.L.","Bailey J.","Bannerjee R.","Barlow K.F.","Bates K.","Beasley H.","Bird C.P.","Bray-Allen S.","Brown A.J.","Brown J.Y.","Burrill W.","Carder C.","Carter N.P.","Chapman J.C.","Clamp M.E.","Clark S.Y.","Clarke G.","Clee C.M.","Clegg S.C.","Cobley V.","Collins J.E.","Corby N.","Coville G.J.","Deloukas P.","Dhami P.","Dunham I.","Dunn M.","Earthrowl M.E.","Ellington A.G.","Faulkner L.","Frankish A.G.","Frankland J.","French L.","Garner P.","Garnett J.","Gilbert J.G.","Gilson C.J.","Ghori J.","Grafham D.V.","Gribble S.M.","Griffiths C.","Hall R.E.","Hammond S.","Harley J.L.","Hart E.A.","Heath P.D.","Howden P.J.","Huckle E.J.","Hunt P.J.","Hunt A.R.","Johnson C.","Johnson D.","Kay M.","Kimberley A.M.","King A.","Laird G.K.","Langford C.J.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Lloyd C.","Loveland J.E.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","McLaren S.J.","McMurray A.","Milne S.","Moore M.J.","Nickerson T.","Palmer S.A.","Pearce A.V.","Peck A.I.","Pelan S.","Phillimore B.","Porter K.M.","Rice C.M.","Searle S.","Sehra H.K.","Shownkeen R.","Skuce C.D.","Smith M.","Steward C.A.","Sycamore N.","Tester J.","Thomas D.W.","Tracey A.","Tromans A.","Tubby B.","Wall M.","Wallis J.M.","West A.P.","Whitehead S.L.","Willey D.L.","Wilming L.","Wray P.W.","Wright M.W.","Young L.","Coulson A.","Durbin R.","Hubbard T.","Sulston J.E.","Beck S.","Bentley D.R.","Rogers J.","Ross M.T."],"citationCrossReferences":[{"database":"PubMed","id":"15057823"},{"database":"DOI","id":"10.1038/nature02379"}],"title":"The DNA sequence and analysis of human chromosome 13.","publicationDate":"2004","journal":"Nature","firstPage":"522","lastPage":"528","volume":"428"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000472346.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000472346.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Burckstummer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"21269460"}]},{"referenceNumber":5,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"24275569"}]},{"referenceNumber":6,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000472346.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL136300","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL137249","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL161896","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL445223","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"KF455815","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"SMR","id":"M0R262","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"M0R262","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"M0R262","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"619","properties":[{"key":"antibodies","value":"214 antibodies from 21 providers"}]},{"database":"Ensembl","id":"ENST00000601009.1","properties":[{"key":"ProteinId","value":"ENSP00000472346.1"},{"key":"GeneId","value":"ENSG00000152767.18"}]},{"database":"UCSC","id":"uc058xxn.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:3591","properties":[{"key":"GeneName","value":"FARP1"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000152767","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000155318","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_003623_1_5_1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"9990815at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"FARP1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 13"}]},{"database":"Bgee","id":"ENSG00000152767","properties":[{"key":"ExpressionPatterns","value":"Expressed in renal medulla and 204 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"M0R262","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"CDD","id":"cd14473","properties":[{"key":"EntryName","value":"FERM_B-lobe"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.80.10:FF:000005","properties":[{"key":"EntryName","value":"FERM, RhoGEF and pleckstrin domain-containing protein 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.80.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.30.29.30","properties":[{"key":"EntryName","value":"Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR019749","properties":[{"key":"EntryName","value":"Band_41_domain"}]},{"database":"InterPro","id":"IPR014352","properties":[{"key":"EntryName","value":"FERM/acyl-CoA-bd_prot_sf"}]},{"database":"InterPro","id":"IPR035963","properties":[{"key":"EntryName","value":"FERM_2"}]},{"database":"InterPro","id":"IPR019748","properties":[{"key":"EntryName","value":"FERM_central"}]},{"database":"InterPro","id":"IPR000299","properties":[{"key":"EntryName","value":"FERM_domain"}]},{"database":"InterPro","id":"IPR018980","properties":[{"key":"EntryName","value":"FERM_PH-like_C"}]},{"database":"InterPro","id":"IPR011993","properties":[{"key":"EntryName","value":"PH-like_dom_sf"}]},{"database":"InterPro","id":"IPR051835","properties":[{"key":"EntryName","value":"RAC1-GEF"}]},{"database":"PANTHER","id":"PTHR45858","properties":[{"key":"EntryName","value":"FERM DOMAIN CONTAINING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR45858:SF2","properties":[{"key":"EntryName","value":"FERM, ARHGEF AND PLECKSTRIN DOMAIN-CONTAINING PROTEIN 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF09380","properties":[{"key":"EntryName","value":"FERM_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00373","properties":[{"key":"EntryName","value":"FERM_M"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00935","properties":[{"key":"EntryName","value":"BAND41"}]},{"database":"SMART","id":"SM01196","properties":[{"key":"EntryName","value":"FERM_C"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF50729","properties":[{"key":"EntryName","value":"PH domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF47031","properties":[{"key":"EntryName","value":"Second domain of FERM"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50057","properties":[{"key":"EntryName","value":"FERM_3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"XYLFALQVKQDLAQGRLTCNDTSAALLISHIVQSEIGDFDEALDREHLAKNKYIPQQDALEDKIVEFHHNHIGQTPAESDFQLLEIARRLEMYGIRLHPAKDREGTKINLAVANTGILVFQGFTKINAFNWAKVRKLSFKRKRFLIKLRPDANFLGWPGARSRGRLHRETT","length":171,"molWeight":19631,"crc64":"B456A4B064DBA1F0","md5":"859DCFB6E70DA67588D92C38750667D7"},"extraAttributes":{"countByFeatureType":{"Domain":1,"Non-terminal residue":1},"uniParcId":"UPI0002A473D1"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"M0QXT1","uniProtkbId":"M0QXT1_HUMAN","entryAudit":{"firstPublicDate":"2013-04-03","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":82,"sequenceVersion":3},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000469365.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000469365.1"}],"value":"FERM, ARH/RhoGEF and pleckstrin domain protein 1"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000469365.1"}],"value":"FARP1"}}],"features":[{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":83,"modifier":"EXACT"}},"description":"DH","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50010"}]},{"type":"Domain","location":{"start":{"value":77,"modifier":"EXACT"},"end":{"value":186,"modifier":"EXACT"}},"description":"PH","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50003"}]},{"type":"Region","location":{"start":{"value":192,"modifier":"EXACT"},"end":{"value":248,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000469365.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":248,"modifier":"EXACT"},"end":{"value":248,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000469365.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"M0QXT1"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"M0QXT1"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000469365.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15057823","citationType":"journal article","authors":["Dunham A.","Matthews L.H.","Burton J.","Ashurst J.L.","Howe K.L.","Ashcroft K.J.","Beare D.M.","Burford D.C.","Hunt S.E.","Griffiths-Jones S.","Jones M.C.","Keenan S.J.","Oliver K.","Scott C.E.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Andrews D.T.","Ashwell R.I.","Babbage A.K.","Bagguley C.L.","Bailey J.","Bannerjee R.","Barlow K.F.","Bates K.","Beasley H.","Bird C.P.","Bray-Allen S.","Brown A.J.","Brown J.Y.","Burrill W.","Carder C.","Carter N.P.","Chapman J.C.","Clamp M.E.","Clark S.Y.","Clarke G.","Clee C.M.","Clegg S.C.","Cobley V.","Collins J.E.","Corby N.","Coville G.J.","Deloukas P.","Dhami P.","Dunham I.","Dunn M.","Earthrowl M.E.","Ellington A.G.","Faulkner L.","Frankish A.G.","Frankland J.","French L.","Garner P.","Garnett J.","Gilbert J.G.","Gilson C.J.","Ghori J.","Grafham D.V.","Gribble S.M.","Griffiths C.","Hall R.E.","Hammond S.","Harley J.L.","Hart E.A.","Heath P.D.","Howden P.J.","Huckle E.J.","Hunt P.J.","Hunt A.R.","Johnson C.","Johnson D.","Kay M.","Kimberley A.M.","King A.","Laird G.K.","Langford C.J.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Lloyd C.","Loveland J.E.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","McLaren S.J.","McMurray A.","Milne S.","Moore M.J.","Nickerson T.","Palmer S.A.","Pearce A.V.","Peck A.I.","Pelan S.","Phillimore B.","Porter K.M.","Rice C.M.","Searle S.","Sehra H.K.","Shownkeen R.","Skuce C.D.","Smith M.","Steward C.A.","Sycamore N.","Tester J.","Thomas D.W.","Tracey A.","Tromans A.","Tubby B.","Wall M.","Wallis J.M.","West A.P.","Whitehead S.L.","Willey D.L.","Wilming L.","Wray P.W.","Wright M.W.","Young L.","Coulson A.","Durbin R.","Hubbard T.","Sulston J.E.","Beck S.","Bentley D.R.","Rogers J.","Ross M.T."],"citationCrossReferences":[{"database":"PubMed","id":"15057823"},{"database":"DOI","id":"10.1038/nature02379"}],"title":"The DNA sequence and analysis of human chromosome 13.","publicationDate":"2004","journal":"Nature","firstPage":"522","lastPage":"528","volume":"428"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000469365.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000469365.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"18669648","citationType":"journal article","authors":["Dephoure N.","Zhou C.","Villen J.","Beausoleil S.A.","Bakalarski C.E.","Elledge S.J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"18669648"},{"database":"DOI","id":"10.1073/pnas.0805139105"}],"title":"A quantitative atlas of mitotic phosphorylation.","publicationDate":"2008","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10762","lastPage":"10767","volume":"105"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"18669648"}]},{"referenceNumber":5,"citation":{"id":"18318008","citationType":"journal article","authors":["Han G.","Ye M.","Zhou H.","Jiang X.","Feng S.","Jiang X.","Tian R.","Wan D.","Zou H.","Gu J."],"citationCrossReferences":[{"database":"PubMed","id":"18318008"},{"database":"DOI","id":"10.1002/pmic.200700884"}],"title":"Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.","publicationDate":"2008","journal":"Proteomics","firstPage":"1346","lastPage":"1361","volume":"8"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"18318008"}]},{"referenceNumber":6,"citation":{"id":"19413330","citationType":"journal article","authors":["Gauci S.","Helbig A.O.","Slijper M.","Krijgsveld J.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"19413330"},{"database":"DOI","id":"10.1021/ac9004309"}],"title":"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.","publicationDate":"2009","journal":"Anal. Chem.","firstPage":"4493","lastPage":"4501","volume":"81"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"19413330"}]},{"referenceNumber":7,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Burckstummer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"21269460"}]},{"referenceNumber":8,"citation":{"id":"21406692","citationType":"journal article","authors":["Rigbolt K.T.","Prokhorova T.A.","Akimov V.","Henningsen J.","Johansen P.T.","Kratchmarova I.","Kassem M.","Mann M.","Olsen J.V.","Blagoev B."],"citationCrossReferences":[{"database":"PubMed","id":"21406692"},{"database":"DOI","id":"10.1126/scisignal.2001570"}],"title":"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.","publicationDate":"2011","journal":"Sci. Signal.","firstPage":"RS3","lastPage":"RS3","volume":"4"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"21406692"}]},{"referenceNumber":9,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"24275569"}]},{"referenceNumber":10,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000469365.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL136300","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL137249","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL161896","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL445223","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"KF455815","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"SMR","id":"M0QXT1","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"M0QXT1","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"M0QXT1","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"619","properties":[{"key":"antibodies","value":"214 antibodies from 21 providers"}]},{"database":"Ensembl","id":"ENST00000596256.1","properties":[{"key":"ProteinId","value":"ENSP00000469365.1"},{"key":"GeneId","value":"ENSG00000152767.18"}]},{"database":"UCSC","id":"uc058xxt.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:3591","properties":[{"key":"GeneName","value":"FARP1"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000152767","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000155318","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_028839_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"9990815at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"FARP1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 13"}]},{"database":"Bgee","id":"ENSG00000152767","properties":[{"key":"ExpressionPatterns","value":"Expressed in renal medulla and 204 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"M0QXT1","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005085","properties":[{"key":"GoTerm","value":"F:guanyl-nucleotide exchange factor activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"1.20.900.10","properties":[{"key":"EntryName","value":"Dbl homology (DH) domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.30.29.30","properties":[{"key":"EntryName","value":"Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR035899","properties":[{"key":"EntryName","value":"DBL_dom_sf"}]},{"database":"InterPro","id":"IPR000219","properties":[{"key":"EntryName","value":"DH_dom"}]},{"database":"InterPro","id":"IPR011993","properties":[{"key":"EntryName","value":"PH-like_dom_sf"}]},{"database":"InterPro","id":"IPR001849","properties":[{"key":"EntryName","value":"PH_domain"}]},{"database":"InterPro","id":"IPR051835","properties":[{"key":"EntryName","value":"RAC1-GEF"}]},{"database":"PANTHER","id":"PTHR45858","properties":[{"key":"EntryName","value":"FERM DOMAIN CONTAINING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR45858:SF2","properties":[{"key":"EntryName","value":"FERM, ARHGEF AND PLECKSTRIN DOMAIN-CONTAINING PROTEIN 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00169","properties":[{"key":"EntryName","value":"PH"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00621","properties":[{"key":"EntryName","value":"RhoGEF"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00233","properties":[{"key":"EntryName","value":"PH"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48065","properties":[{"key":"EntryName","value":"DBL homology domain (DH-domain)"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF50729","properties":[{"key":"EntryName","value":"PH domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50010","properties":[{"key":"EntryName","value":"DH_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50003","properties":[{"key":"EntryName","value":"PH_DOMAIN"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"XEALENGIKSSRRLENFCRDFELQKVCYLPLNTFLLRPLHRLMHYKQVLERLCKHHPPSHADFRDCRAALAEITEMVAQLHGTMIKMENFQKLHELKKDLIGIDNLVVPGRFNDVLLYTSRGLTASNQFKVHGQLPLYGMTIEESEDEWGVPHCLTLRGQRQSIIVAASSRSEMEKWVEDIQMAIDLAEKSSSPAPEFLASSPPDNKSPDEATAADQESEDDLSASRTSLERQAPHRGNTMVHVCWHR","length":248,"molWeight":28268,"crc64":"0EDAD442F271CDCD","md5":"FF21A341BBA790BD96917A919E9852AD"},"extraAttributes":{"countByFeatureType":{"Domain":2,"Region":1,"Non-terminal residue":2},"uniParcId":"UPI0002A47773"}}]}