{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q7L5A8","secondaryAccessions":["B7Z8T6","O75213","Q96DK1","Q9H1A5"],"uniProtkbId":"FA2H_HUMAN","entryAudit":{"firstPublicDate":"2007-12-04","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2004-11-23","entryVersion":178,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15337768"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15863841"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"17355976"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"22517924"}],"value":"Fatty acid 2-hydroxylase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15337768"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15863841"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17355976"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22517924"}],"value":"1.14.18.-"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15863841"}],"value":"Fatty acid alpha-hydroxylase"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:21197"}],"value":"Fatty acid hydroxylase domain-containing protein 1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15337768"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15863841"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"17355976"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"22517924"},{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:21197"}],"value":"FA2H"},"synonyms":[{"value":"FAAH"},{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:21197"}],"value":"FAXDC1"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q5MPP0"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15337768"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15863841"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17355976"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22517924"}],"value":"Catalyzes the hydroxylation of free fatty acids at the C-2 position to produce 2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis (PubMed:15337768, PubMed:15863841, PubMed:17355976, PubMed:22517924). 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