{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9NQ30","secondaryAccessions":["B2R4G3","Q15330","Q3V4E3","Q96ES3"],"uniProtkbId":"ESM1_HUMAN","entryAudit":{"firstPublicDate":"2001-04-27","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2001-04-27","entryVersion":177,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Endothelial cell-specific molecule 1"},"shortNames":[{"value":"ESM-1"}]},"flag":"Precursor"},"genes":[{"geneName":{"value":"ESM1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20616313"}],"value":"Involved in angiogenesis; promotes angiogenic sprouting. May have potent implications in lung endothelial cell-leukocyte interactions"}],"commentType":"FUNCTION"},{"texts":[{"value":"Monomer"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q9NQ30","intActId":"EBI-12260294"},"interactantTwo":{"uniProtKBAccession":"O43184-4","geneName":"ADAM12","intActId":"EBI-12006944"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9NQ30","intActId":"EBI-12260294"},"interactantTwo":{"uniProtKBAccession":"Q49AR9","geneName":"ANKS1A","intActId":"EBI-11954519"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9NQ30","intActId":"EBI-12260294"},"interactantTwo":{"uniProtKBAccession":"P29972","geneName":"AQP1","intActId":"EBI-745213"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9NQ30","intActId":"EBI-12260294"},"interactantTwo":{"uniProtKBAccession":"Q8N9N5-2","geneName":"BANP","intActId":"EBI-11524452"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9NQ30","intActId":"EBI-12260294"},"interactantTwo":{"uniProtKBAccession":"Q9H5Z6-2","geneName":"FAM124B","intActId":"EBI-11986315"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9NQ30","intActId":"EBI-12260294"},"interactantTwo":{"uniProtKBAccession":"O43559","geneName":"FRS3","intActId":"EBI-725515"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9NQ30","intActId":"EBI-12260294"},"interactantTwo":{"uniProtKBAccession":"Q8WUI4-6","geneName":"HDAC7","intActId":"EBI-12094670"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9NQ30","intActId":"EBI-12260294"},"interactantTwo":{"uniProtKBAccession":"P49639","geneName":"HOXA1","intActId":"EBI-740785"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9NQ30","intActId":"EBI-12260294"},"interactantTwo":{"uniProtKBAccession":"O60333-2","geneName":"KIF1B","intActId":"EBI-10975473"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9NQ30","intActId":"EBI-12260294"},"interactantTwo":{"uniProtKBAccession":"Q6FHY5","geneName":"MEOX2","intActId":"EBI-16439278"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9NQ30","intActId":"EBI-12260294"},"interactantTwo":{"uniProtKBAccession":"Q16656-4","geneName":"NRF1","intActId":"EBI-11742836"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9NQ30","intActId":"EBI-12260294"},"interactantTwo":{"uniProtKBAccession":"Q7Z417","geneName":"NUFIP2","intActId":"EBI-1210753"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9NQ30","intActId":"EBI-12260294"},"interactantTwo":{"uniProtKBAccession":"O43741","geneName":"PRKAB2","intActId":"EBI-1053424"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9NQ30","intActId":"EBI-12260294"},"interactantTwo":{"uniProtKBAccession":"Q9Y3C5","geneName":"RNF11","intActId":"EBI-396669"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9NQ30","intActId":"EBI-12260294"},"interactantTwo":{"uniProtKBAccession":"A8MV65-2","geneName":"VGLL3","intActId":"EBI-11957216"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9NQ30","intActId":"EBI-12260294"},"interactantTwo":{"uniProtKBAccession":"O76024","geneName":"WFS1","intActId":"EBI-720609"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9NQ30","intActId":"EBI-12260294"},"interactantTwo":{"uniProtKBAccession":"P25490","geneName":"YY1","intActId":"EBI-765538"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"value":"Secreted","id":"SL-0243"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q9NQ30-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q9NQ30-2"],"sequenceIds":["VSP_042631"],"isoformSequenceStatus":"Described"}]},{"texts":[{"value":"Expressed in lung, on the vascular capillary network within alveolar walls, and also at lower level in kidney"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"value":"By TNF and IL1B/interleukin-1 beta, but not IL4/interleukin-4"}],"commentType":"INDUCTION"},{"texts":[{"value":"May contain intrachain disulfide bonds"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20581009"}],"value":"O-glycosylated; contains chondroitin sulfate and dermatan sulfate"}],"commentType":"PTM"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":19,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Chain","location":{"start":{"value":20,"modifier":"EXACT"},"end":{"value":184,"modifier":"EXACT"}},"description":"Endothelial cell-specific molecule 1","featureId":"PRO_0000014394"},{"type":"Domain","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":102,"modifier":"EXACT"}},"description":"IGFBP N-terminal","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00653"}]},{"type":"Glycosylation","location":{"start":{"value":156,"modifier":"EXACT"},"end":{"value":156,"modifier":"EXACT"}},"description":"O-linked (Xyl...) (chondroitin sulfate) serine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20581009"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32337544"}],"featureId":""},{"type":"Disulfide bond","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":51,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00653"}]},{"type":"Disulfide bond","location":{"start":{"value":32,"modifier":"EXACT"},"end":{"value":53,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00653"}]},{"type":"Disulfide bond","location":{"start":{"value":37,"modifier":"EXACT"},"end":{"value":54,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00653"}]},{"type":"Disulfide bond","location":{"start":{"value":43,"modifier":"EXACT"},"end":{"value":57,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00653"}]},{"type":"Disulfide bond","location":{"start":{"value":65,"modifier":"EXACT"},"end":{"value":83,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00653"}]},{"type":"Disulfide bond","location":{"start":{"value":77,"modifier":"EXACT"},"end":{"value":99,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00653"}]},{"type":"Alternative sequence","location":{"start":{"value":101,"modifier":"EXACT"},"end":{"value":150,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"},{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.3"}],"featureId":"VSP_042631","alternativeSequence":{}},{"type":"Sequence conflict","location":{"start":{"value":44,"modifier":"EXACT"},"end":{"value":44,"modifier":"EXACT"}},"description":"in Ref. 6; AAH11989","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["E"]}},{"type":"Sequence conflict","location":{"start":{"value":151,"modifier":"EXACT"},"end":{"value":151,"modifier":"EXACT"}},"description":"in Ref. 2; CAB94771","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{}}],"keywords":[{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0037","category":"Biological process","name":"Angiogenesis"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-0654","category":"PTM","name":"Proteoglycan"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"8702785","citationType":"journal article","authors":["Lassalle P.","Molet S.","Janin A.","Vander-Heyden J.E.","Tavernier J.","Fiers W.","Devos R.E.","Tonnel A.-B."],"citationCrossReferences":[{"database":"PubMed","id":"8702785"},{"database":"DOI","id":"10.1074/jbc.271.34.20458"}],"title":"ESM-1 is a novel human endothelial cell-specific molecule expressed in lung and regulated by cytokines.","publicationDate":"1996","journal":"J. Biol. Chem.","firstPage":"20458","lastPage":"20464","volume":"271"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"Umbilical vein endothelial cell","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"CI-AHHKPE7379CK1","citationType":"submission","authors":["Vedrenne C.","Kervoaze G.","Lassalle P."],"title":"Sequencing of the human ESM-1 gene and analysis of its 5' flanking region.","publicationDate":"JUN-2000","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"Leukocyte","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"CI-63AIN3KJ5398A","citationType":"submission","authors":["Depontieu F.","Grigoriu B.","Scherpereel A.","Adam E.","Lafitte J.J.","Ouatas T.","Delehedde M.","Lyon M.","Copin M.C.","Janin A.","Tonnel A.B.","Tsicopoulos A.","Lassalle P."],"title":"Exon 2 of the endocan gene contributes to tumorigenesis and its expression is increased in human lung tumor vascular cells.","publicationDate":"JUN-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)"]},{"referenceNumber":4,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)"],"referenceComments":[{"value":"Thalamus","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"15372022","citationType":"journal article","authors":["Schmutz J.","Martin J.","Terry A.","Couronne O.","Grimwood J.","Lowry S.","Gordon L.A.","Scott D.","Xie G.","Huang W.","Hellsten U.","Tran-Gyamfi M.","She X.","Prabhakar S.","Aerts A.","Altherr M.","Bajorek E.","Black S.","Branscomb E.","Caoile C.","Challacombe J.F.","Chan Y.M.","Denys M.","Detter J.C.","Escobar J.","Flowers D.","Fotopulos D.","Glavina T.","Gomez M.","Gonzales E.","Goodstein D.","Grigoriev I.","Groza M.","Hammon N.","Hawkins T.","Haydu L.","Israni S.","Jett J.","Kadner K.","Kimball H.","Kobayashi A.","Lopez F.","Lou Y.","Martinez D.","Medina C.","Morgan J.","Nandkeshwar R.","Noonan J.P.","Pitluck S.","Pollard M.","Predki P.","Priest J.","Ramirez L.","Retterer J.","Rodriguez A.","Rogers S.","Salamov A.","Salazar A.","Thayer N.","Tice H.","Tsai M.","Ustaszewska A.","Vo N.","Wheeler J.","Wu K.","Yang J.","Dickson M.","Cheng J.-F.","Eichler E.E.","Olsen A.","Pennacchio L.A.","Rokhsar D.S.","Richardson P.","Lucas S.M.","Myers R.M.","Rubin E.M."],"citationCrossReferences":[{"database":"PubMed","id":"15372022"},{"database":"DOI","id":"10.1038/nature02919"}],"title":"The DNA sequence and comparative analysis of human chromosome 5.","publicationDate":"2004","journal":"Nature","firstPage":"268","lastPage":"274","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":6,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"Lung","type":"TISSUE"}]},{"referenceNumber":7,"citation":{"id":"20616313","citationType":"journal article","authors":["Brutsch R.","Liebler S.S.","Wustehube J.","Bartol A.","Herberich S.E.","Adam M.G.","Telzerow A.","Augustin H.G.","Fischer A."],"citationCrossReferences":[{"database":"PubMed","id":"20616313"},{"database":"DOI","id":"10.1161/circresaha.110.217257"}],"title":"Integrin cytoplasmic domain-associated protein-1 attenuates sprouting angiogenesis.","publicationDate":"2010","journal":"Circ. Res.","firstPage":"592","lastPage":"601","volume":"107"},"referencePositions":["FUNCTION"]},{"referenceNumber":8,"citation":{"id":"20581009","citationType":"journal article","authors":["Sarrazin S.","Lyon M.","Deakin J.A.","Guerrini M.","Lassalle P.","Delehedde M.","Lortat-Jacob H."],"citationCrossReferences":[{"database":"PubMed","id":"20581009"},{"database":"DOI","id":"10.1093/glycob/cwq100"}],"title":"Characterization and binding activity of the chondroitin/dermatan sulfate chain from Endocan, a soluble endothelial proteoglycan.","publicationDate":"2010","journal":"Glycobiology","firstPage":"1380","lastPage":"1388","volume":"20"},"referencePositions":["GLYCOSYLATION AT SER-156"]},{"referenceNumber":9,"citation":{"id":"32337544","citationType":"journal article","authors":["Toledo A.G.","Pihl J.","Spliid C.B.","Persson A.","Nilsson J.","Pereira M.A.","Gustavsson T.","Choudhary S.","Oo H.Z.","Black P.C.","Daugaard M.","Esko J.D.","Larson G.","Salanti A.","Clausen T.M."],"citationCrossReferences":[{"database":"PubMed","id":"32337544"},{"database":"DOI","id":"10.1093/glycob/cwaa039"}],"title":"An affinity chromatography and glycoproteomics workflow to profile the chondroitin sulfate proteoglycans that interact with malarial VAR2CSA in the placenta and in cancer.","publicationDate":"2020","journal":"Glycobiology","firstPage":"989","lastPage":"1002","volume":"30"},"referencePositions":["GLYCOSYLATION AT SER-156"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"X89426","properties":[{"key":"ProteinId","value":"CAA61597.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AJ401091","properties":[{"key":"ProteinId","value":"CAB94771.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AJ401092","properties":[{"key":"ProteinId","value":"CAB94771.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AJ973643","properties":[{"key":"ProteinId","value":"CAJ13737.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK300634","properties":[{"key":"ProteinId","value":"BAG62324.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK311817","properties":[{"key":"ProteinId","value":"BAG34760.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AC010436","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC034238","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC011989","properties":[{"key":"ProteinId","value":"AAH11989.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS3963.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9NQ30-1"},{"database":"CCDS","id":"CCDS47206.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9NQ30-2"},{"database":"RefSeq","id":"NP_001129076.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001135604.2"}],"isoformId":"Q9NQ30-2"},{"database":"RefSeq","id":"NP_008967.1","properties":[{"key":"NucleotideSequenceId","value":"NM_007036.5"}],"isoformId":"Q9NQ30-1"},{"database":"AlphaFoldDB","id":"Q9NQ30","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"116265","properties":[{"key":"Interactions","value":"19"}]},{"database":"FunCoup","id":"Q9NQ30","properties":[{"key":"Number of interactors","value":"43"}]},{"database":"IntAct","id":"Q9NQ30","properties":[{"key":"Interactions","value":"18"}]},{"database":"NDEx","id":"IQUERY-CP-ESM1","properties":[{"key":"Evidences","value":"1 NDEx IQuery Curated Pathway"}]},{"database":"STRING","id":"9606.ENSP00000370812","properties":[{"key":"Description","value":"-"}]},{"database":"GlyCosmos","id":"Q9NQ30","properties":[{"key":"glycosylation","value":"1 site, No reported glycans"}]},{"database":"GlyGen","id":"Q9NQ30","properties":[{"key":"glycosylation","value":"1 site"}]},{"database":"iPTMnet","id":"Q9NQ30","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q9NQ30","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"ESM1","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"13431509","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q9NQ30","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000370812","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q9NQ30","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"82061","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9NQ30-1"},{"database":"ProteomicsDB","id":"82062","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9NQ30-2"},{"database":"Antibodypedia","id":"23370","properties":[{"key":"antibodies","value":"276 antibodies from 27 providers"}]},{"database":"DNASU","id":"11082","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000381403.4","properties":[{"key":"ProteinId","value":"ENSP00000370810.4"},{"key":"GeneId","value":"ENSG00000164283.13"}],"isoformId":"Q9NQ30-2"},{"database":"Ensembl","id":"ENST00000381405.5","properties":[{"key":"ProteinId","value":"ENSP00000370812.4"},{"key":"GeneId","value":"ENSG00000164283.13"}],"isoformId":"Q9NQ30-1"},{"database":"GeneID","id":"11082","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:11082","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000381405.5","properties":[{"key":"ProteinId","value":"ENSP00000370812.4"},{"key":"RefSeqNucleotideId","value":"NM_007036.5"},{"key":"RefSeqProteinId","value":"NP_008967.1"}]},{"database":"UCSC","id":"uc003jpk.4","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"Q9NQ30-1"},{"database":"AGR","id":"HGNC:3466","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA27883","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"11082","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"11082","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"ESM1","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:3466","properties":[{"key":"GeneName","value":"ESM1"}]},{"database":"HPA","id":"ENSG00000164283","properties":[{"key":"ExpressionPatterns","value":"Tissue enhanced (kidney, thyroid gland)"}]},{"database":"MIM","id":"601521","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000164283","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000164283","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG1218","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000018810","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_103395_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q9NQ30","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"TAWSAKY","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9868586at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q9NQ30","properties":[{"key":"Number of GO annotations","value":"4 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q9NQ30","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q9NQ30","properties":[{"key":"Description","value":"-"}]},{"database":"SignaLink","id":"Q9NQ30","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000164283","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"11082","properties":[{"key":"hits","value":"8 hits in 1139 CRISPR screens"}]},{"database":"GeneWiki","id":"ESM1","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"11082","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q9NQ30","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:Q9NQ30","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 5"}]},{"database":"RNAct","id":"Q9NQ30","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000164283","properties":[{"key":"ExpressionPatterns","value":"Expressed in islet of Langerhans and 111 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q9NQ30","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0031012","properties":[{"key":"GoTerm","value":"C:extracellular matrix"},{"key":"GoEvidenceType","value":"HDA:GO_Central"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"27068509"},{"evidenceCode":"ECO:0007005","source":"PubMed","id":"33266304"}]},{"database":"GO","id":"GO:0005201","properties":[{"key":"GoTerm","value":"F:extracellular matrix structural constituent"},{"key":"GoEvidenceType","value":"HDA:GO_Central"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"27068509"}]},{"database":"GO","id":"GO:0005171","properties":[{"key":"GoTerm","value":"F:hepatocyte growth factor receptor binding"},{"key":"GoEvidenceType","value":"IPI:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"11590178"}]},{"database":"GO","id":"GO:0005178","properties":[{"key":"GoTerm","value":"F:integrin binding"},{"key":"GoEvidenceType","value":"IPI:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"11544294"}]},{"database":"GO","id":"GO:0001525","properties":[{"key":"GoTerm","value":"P:angiogenesis"},{"key":"GoEvidenceType","value":"IEP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000270","source":"PubMed","id":"11866539"}]},{"database":"GO","id":"GO:0008284","properties":[{"key":"GoTerm","value":"P:positive regulation of cell population proliferation"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11590178"}]},{"database":"GO","id":"GO:1902204","properties":[{"key":"GoTerm","value":"P:positive regulation of hepatocyte growth factor receptor signaling pathway"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11590178"}]},{"database":"GO","id":"GO:0002040","properties":[{"key":"GoTerm","value":"P:sprouting angiogenesis"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"20616313"}]},{"database":"FunFam","id":"4.10.40.20:FF:000002","properties":[{"key":"EntryName","value":"Endothelial cell-specific molecule 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"4.10.40.20","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR038850","properties":[{"key":"EntryName","value":"ESM1"}]},{"database":"InterPro","id":"IPR009030","properties":[{"key":"EntryName","value":"Growth_fac_rcpt_cys_sf"}]},{"database":"InterPro","id":"IPR000867","properties":[{"key":"EntryName","value":"IGFBP-like"}]},{"database":"PANTHER","id":"PTHR15428:SF0","properties":[{"key":"EntryName","value":"ENDOTHELIAL CELL-SPECIFIC MOLECULE 1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR15428","properties":[{"key":"EntryName","value":"ENDOTHELIAL CELL-SPECIFIC MOLECULE 1 ESM-1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00219","properties":[{"key":"EntryName","value":"IGFBP"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00121","properties":[{"key":"EntryName","value":"IB"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57184","properties":[{"key":"EntryName","value":"Growth factor receptor domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51323","properties":[{"key":"EntryName","value":"IGFBP_N_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MKSVLLLTTLLVPAHLVAAWSNNYAVDCPQHCDSSECKSSPRCKRTVLDDCGCCRVCAAGRGETCYRTVSGMDGMKCGPGLRCQPSNGEDPFGEEFGICKDCPYGTFGMDCRETCNCQSGICDRGTGKCLKFPFFQYSVTKSSNRFVSLTEHDMASGDGNIVREEVVKENAAGSPVMRKWLNPR","length":184,"molWeight":20095,"crc64":"2AD15EDEC74BC8CE","md5":"BB291495C6A9EA9EC86744FC93C9D632"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"INTERACTION":17,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":2,"TISSUE SPECIFICITY":1,"INDUCTION":1,"PTM":2},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":1,"Glycosylation":1,"Disulfide bond":6,"Alternative sequence":1,"Sequence conflict":2},"uniParcId":"UPI000012A1BA"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"M0R154","uniProtkbId":"M0R154_HUMAN","entryAudit":{"firstPublicDate":"2013-04-03","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2013-04-03","entryVersion":71,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000471642.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000471642.1"}],"value":"Endothelial cell specific molecule 1"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000471642.1"}],"value":"ESM1"}}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":19,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":20,"modifier":"EXACT"},"end":{"value":89,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5004004104"},{"type":"Domain","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":89,"modifier":"EXACT"}},"description":"IGFBP N-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51323"}]},{"type":"Non-terminal residue","location":{"start":{"value":89,"modifier":"EXACT"},"end":{"value":89,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000471642.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"M0R154"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"M0R154"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000471642.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15372022","citationType":"journal article","authors":["Schmutz J.","Martin J.","Terry A.","Couronne O.","Grimwood J.","Lowry S.","Gordon L.A.","Scott D.","Xie G.","Huang W.","Hellsten U.","Tran-Gyamfi M.","She X.","Prabhakar S.","Aerts A.","Altherr M.","Bajorek E.","Black S.","Branscomb E.","Caoile C.","Challacombe J.F.","Chan Y.M.","Denys M.","Detter J.C.","Escobar J.","Flowers D.","Fotopulos D.","Glavina T.","Gomez M.","Gonzales E.","Goodstein D.","Grigoriev I.","Groza M.","Hammon N.","Hawkins T.","Haydu L.","Israni S.","Jett J.","Kadner K.","Kimball H.","Kobayashi A.","Lopez F.","Lou Y.","Martinez D.","Medina C.","Morgan J.","Nandkeshwar R.","Noonan J.P.","Pitluck S.","Pollard M.","Predki P.","Priest J.","Ramirez L.","Retterer J.","Rodriguez A.","Rogers S.","Salamov A.","Salazar A.","Thayer N.","Tice H.","Tsai M.","Ustaszewska A.","Vo N.","Wheeler J.","Wu K.","Yang J.","Dickson M.","Cheng J.F.","Eichler E.E.","Olsen A.","Pennacchio L.A.","Rokhsar D.S.","Richardson P.","Lucas S.M.","Myers R.M.","Rubin E.M."],"citationCrossReferences":[{"database":"PubMed","id":"15372022"},{"database":"DOI","id":"10.1038/nature02919"}],"title":"The DNA sequence and comparative analysis of human chromosome 5.","publicationDate":"2004","journal":"Nature","firstPage":"268","lastPage":"274","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000471642.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000471642.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000471642.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC010436","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC034238","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"M0R154","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"M0R154","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"M0R154","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"23370","properties":[{"key":"antibodies","value":"276 antibodies from 27 providers"}]},{"database":"Ensembl","id":"ENST00000601836.1","properties":[{"key":"ProteinId","value":"ENSP00000471642.1"},{"key":"GeneId","value":"ENSG00000164283.13"}]},{"database":"UCSC","id":"uc063dot.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:3466","properties":[{"key":"GeneName","value":"ESM1"}]},{"database":"OpenTargets","id":"ENSG00000164283","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000164283","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00390000018810","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_2460481_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"TAWSAKY","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9868586at2759","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 5"}]},{"database":"Bgee","id":"ENSG00000164283","properties":[{"key":"ExpressionPatterns","value":"Expressed in islet of Langerhans and 111 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"M0R154","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"4.10.40.20","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR038850","properties":[{"key":"EntryName","value":"ESM1"}]},{"database":"InterPro","id":"IPR009030","properties":[{"key":"EntryName","value":"Growth_fac_rcpt_cys_sf"}]},{"database":"InterPro","id":"IPR000867","properties":[{"key":"EntryName","value":"IGFBP-like"}]},{"database":"PANTHER","id":"PTHR15428:SF0","properties":[{"key":"EntryName","value":"ENDOTHELIAL CELL-SPECIFIC MOLECULE 1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR15428","properties":[{"key":"EntryName","value":"ENDOTHELIAL CELL-SPECIFIC MOLECULE 1 ESM-1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00219","properties":[{"key":"EntryName","value":"IGFBP"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00121","properties":[{"key":"EntryName","value":"IB"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57184","properties":[{"key":"EntryName","value":"Growth factor receptor domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51323","properties":[{"key":"EntryName","value":"IGFBP_N_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MKSVLLLTTLLVPAHLVAAWSNNYAVDCPQHCDSSECKSSPRCKRTVLDDCGCCRVCAAGRGETCYRTVSGMDGMKCGPGLRCQPSNGE","length":89,"molWeight":9514,"crc64":"D86F0334A163AB85","md5":"EFA8A635339A2E253893939CFB0CCDD4"},"extraAttributes":{"countByFeatureType":{"Signal":1,"Chain":1,"Domain":1,"Non-terminal residue":1},"uniParcId":"UPI0002A47737"}}]}