{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P34913","secondaryAccessions":["B2Z3B1","B3KTU8","B3KUA0","G3V134","J3KPH7","Q16764","Q9HBJ1","Q9HBJ2"],"uniProtkbId":"HYES_HUMAN","entryAudit":{"firstPublicDate":"1994-02-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2005-06-07","entryVersion":224,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Bifunctional epoxide hydrolase 2"}},"includes":[{"recommendedName":{"fullName":{"value":"Cytosolic epoxide hydrolase 2"},"shortNames":[{"value":"CEH"}],"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12574510"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12869654"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15196990"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22798687"}],"value":"3.3.2.10"}]},"alternativeNames":[{"fullName":{"value":"Epoxide hydratase"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"21217101"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"22217705"}],"value":"Soluble epoxide hydrolase"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"21217101"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"22217705"}],"value":"SEH"}]}]},{"recommendedName":{"fullName":{"value":"Lipid-phosphate phosphatase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12574508"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12574510"}],"value":"3.1.3.76"}]}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:3402"}],"value":"EPHX2"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P80299"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12574508"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12574510"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12869654"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21217101"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22798687"}],"value":"Bifunctional enzyme (PubMed:12574510). The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides (PubMed:12574510, PubMed:12869654, PubMed:22798687). Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides (By similarity). Also determines steady-state levels of physiological mediators (PubMed:12574510, PubMed:12869654, PubMed:21217101, PubMed:22798687)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12574510"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22217705"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22387545"}],"value":"Bifunctional enzyme (PubMed:12574510). The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid and 12-phosphonooxy-octadec-9E-enoic acid (PubMed:12574510). Has phosphatase activity toward lyso-glycerophospholipids with also some lower activity toward lysolipids of sphingolipid and isoprenoid phosphates (PubMed:22217705, PubMed:22387545)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"an epoxide + H2O = an ethanediol","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:19037"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:32955"},{"database":"ChEBI","id":"CHEBI:140594"}],"ecNumber":"3.3.2.10","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12574510"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12869654"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22798687"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(9S,10S)-10-hydroxy-9-(phosphooxy)octadecanoate + H2O = (9S,10S)-9,10-dihydroxyoctadecanoate + 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by 1-(1-acetylpiperidin-4-yl)-3-(4-(trifl uoromethoxy)phenyl)urea (TPAU), 1-cyclohexyl-3-dodecylurea (CDU), 12-(3-adamantan-1-yl-ureido)-dodecanoic acid (AUDA), 1-((3S, 5S, 7S)-adamantan-1-yl)-3-(5-(2-(2-ethoxyethoxy) ethoxy)pentyl)urea (AEPU), N-adamantyl-N[']-cyclohexyl urea (ACU), 4-(((1S, 4S)-4-(3-((3S, 5S, 7S)-adamantan-1-yl) ureido)cyclohexyl)oxy)benzoic acid (c-AUCB), 4-(((1R, 4R)-4-(3-((3S, 5S, 7S)-adamantan-1-yl)ureido)cyclohexyl)oxy)benzoic acid (t-AUCB), 4-(((1R, 4R)-4-(3-(4(trifluoromethoxy)phenyl)ureido)cyclohexyl)oxy)benzoic acid (t-TAUCB) and to a lesser extent by 8-(3-((3S, 5S, 7S)-adamantan-1-yl)ureido) octanoic acid (AUOA). 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