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Required for normal structure and integrity of adult vasculature (PubMed:7894484). Regulates the migration of vascular endothelial cells (PubMed:17540773). Required for normal extraembryonic angiogenesis and for embryonic heart development (By similarity). May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (By similarity). May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors (PubMed:1692830). Acts as a TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade that ultimately leads to the activation of SMAD transcription factors (PubMed:21737454, PubMed:22347366, PubMed:23300529, PubMed:8370410). Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGFB1 signaling through SMAD3 (PubMed:21737454, PubMed:22347366, PubMed:23300529)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1326540"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16982625"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17540773"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21737454"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22347366"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28564608"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8370410"}],"value":"Homodimer; disulfide-linked (PubMed:1326540, PubMed:21737454, PubMed:22347366, PubMed:28564608, PubMed:8370410). Forms a heteromeric complex with the signaling receptors for transforming growth factor-beta: TGFBR1 and/or TGFBR2 (PubMed:1326540). It is able to bind TGFB1 and TGFB2 with high affinity, but not TGFB3 (PubMed:1326540, PubMed:8370410). Interacts with GDF2, forming a heterotetramer with a 2:2 stoichiometry (PubMed:21737454, PubMed:22347366, PubMed:28564608). Interacts with ACVRL1 (PubMed:22347366, PubMed:28564608). Can form a heteromeric complex with GDF2 and ACVRL1 (PubMed:28564608). Interacts with BMP10 (PubMed:21737454). Interacts with DYNLT4 (PubMed:16982625). Interacts with ARRB2 (PubMed:17540773)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P17813","intActId":"EBI-2834630"},"interactantTwo":{"uniProtKBAccession":"P17813","geneName":"ENG","intActId":"EBI-2834630"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P17813","intActId":"EBI-2834630"},"interactantTwo":{"uniProtKBAccession":"Q9UK05","geneName":"GDF2","chainId":"PRO_0000033903","intActId":"EBI-16227344"},"numberOfExperiments":10,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P17813","intActId":"EBI-2834630"},"interactantTwo":{"uniProtKBAccession":"P08648","geneName":"ITGA5","intActId":"EBI-1382311"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P17813","intActId":"EBI-2834630"},"interactantTwo":{"uniProtKBAccession":"P05556","geneName":"ITGB1","intActId":"EBI-703066"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P17813","intActId":"EBI-2834630"},"interactantTwo":{"uniProtKBAccession":"P17931","geneName":"LGALS3","intActId":"EBI-1170392"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P17813","intActId":"EBI-2834630"},"interactantTwo":{"uniProtKBAccession":"P01137","geneName":"TGFB1","intActId":"EBI-779636"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P17813","intActId":"EBI-2834630"},"interactantTwo":{"uniProtKBAccession":"P19474","geneName":"TRIM21","intActId":"EBI-81290"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P17813-1","intActId":"EBI-16065304"},"interactantTwo":{"uniProtKBAccession":"P02750","geneName":"LRG1","intActId":"EBI-9083443"},"numberOfExperiments":4,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10545596"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1326540"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1692830"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17540773"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8370410"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"1692830"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"8370410"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"Long"},"isoformIds":["P17813-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"Short"},"isoformIds":["P17813-2"],"sequenceIds":["VSP_004233"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10625079"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1692830"}],"value":"Detected on umbilical veil endothelial cells (PubMed:10625079). Detected in placenta (at protein level) (PubMed:1692830). Detected on endothelial cells (PubMed:1692830)"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28564608"}],"value":"The ZP domain mediates dimerization"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28564608"}],"value":"The N-terminal OR region is composed of two intertwined domains (OR1 and OR2) with a common, novel fold. Each contains 12 beta-strands that form a parallel beta-helix-like structure, plus a single alpha-helix. The OR1 region mediates interaction with GDF2"}],"commentType":"DOMAIN"},{"commentType":"DISEASE","disease":{"diseaseId":"Telangiectasia, hereditary hemorrhagic, 1","diseaseAccession":"DI-01716","acronym":"HHT1","description":"A multisystemic vascular dysplasia leading to dilation of permanent blood vessels and arteriovenous malformations of skin, mucosa, and viscera. 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Visceral involvement includes arteriovenous malformations of the lung, liver, and brain.","diseaseCrossReference":{"database":"MIM","id":"187300"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10545596"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10625079"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10982033"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15024723"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15712270"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16525724"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16752392"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20414677"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7894484"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9157574"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9245986"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9554745"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"commentType":"WEB RESOURCE","resourceName":"Atlas of Genetics and Cytogenetics in Oncology and Haematology","resourceUrl":"https://atlasgeneticsoncology.org/gene/40452/ENG","ftp":false},{"commentType":"WEB RESOURCE","resourceName":"Hereditary Hemorrhagic Telangiectasia and ENG","resourceUrl":"http://arup.utah.edu/database/ENG/ENG_welcome.php","ftp":false}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":25,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1692830"}]},{"type":"Chain","location":{"start":{"value":26,"modifier":"EXACT"},"end":{"value":658,"modifier":"EXACT"}},"description":"Endoglin","featureId":"PRO_0000021156"},{"type":"Topological domain","location":{"start":{"value":26,"modifier":"EXACT"},"end":{"value":586,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":587,"modifier":"EXACT"},"end":{"value":611,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":612,"modifier":"EXACT"},"end":{"value":658,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Domain","location":{"start":{"value":363,"modifier":"EXACT"},"end":{"value":533,"modifier":"EXACT"}},"description":"ZP","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00375"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"28564608"}]},{"type":"Region","location":{"start":{"value":26,"modifier":"EXACT"},"end":{"value":337,"modifier":"EXACT"}},"description":"Required for interaction with GDF2","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21737454"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22347366"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28564608"}]},{"type":"Region","location":{"start":{"value":26,"modifier":"EXACT"},"end":{"value":46,"modifier":"EXACT"}},"description":"OR1, N-terminal part","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28564608"}]},{"type":"Region","location":{"start":{"value":47,"modifier":"EXACT"},"end":{"value":199,"modifier":"EXACT"}},"description":"OR2","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28564608"}]},{"type":"Region","location":{"start":{"value":200,"modifier":"EXACT"},"end":{"value":330,"modifier":"EXACT"}},"description":"OR1, C-terminal part","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28564608"}]},{"type":"Region","location":{"start":{"value":270,"modifier":"EXACT"},"end":{"value":282,"modifier":"EXACT"}},"description":"Essential for interaction with GDF2","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28564608"}]},{"type":"Region","location":{"start":{"value":626,"modifier":"EXACT"},"end":{"value":658,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Motif","location":{"start":{"value":399,"modifier":"EXACT"},"end":{"value":401,"modifier":"EXACT"}},"description":"Cell attachment site","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Compositional bias","location":{"start":{"value":626,"modifier":"EXACT"},"end":{"value":639,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":640,"modifier":"EXACT"},"end":{"value":658,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":646,"modifier":"EXACT"},"end":{"value":646,"modifier":"EXACT"}},"description":"Phosphoserine; 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