{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P05198","uniProtkbId":"IF2A_HUMAN","entryAudit":{"firstPublicDate":"1987-08-13","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2007-01-23","entryVersion":240,"sequenceVersion":3},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Eukaryotic translation initiation factor 2 subunit 1"}},"alternativeNames":[{"fullName":{"value":"Eukaryotic translation initiation factor 2 subunit alpha"},"shortNames":[{"value":"eIF-2-alpha"},{"value":"eIF-2A"},{"value":"eIF-2alpha"},{"value":"eIF2-alpha"}]}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:3265"}],"value":"EIF2S1"},"synonyms":[{"value":"EIF2A"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16289705"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19131336"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33384352"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38340717"}],"value":"Member of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (PubMed:16289705, PubMed:38340717). This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex (43S PIC) (PubMed:16289705). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex (PubMed:16289705). In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B (PubMed:16289705). EIF2S1/eIF2-alpha is a key component of the integrated stress response (ISR), required for adaptation to various stress: phosphorylation by metabolic-stress sensing protein kinases (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2) in response to stress converts EIF2S1/eIF2-alpha in a global protein synthesis inhibitor, leading to an attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activators ATF4 and QRICH1, and hence allowing ATF4- and QRICH1-mediated reprogramming (PubMed:19131336, PubMed:33384352, PubMed:38340717). EIF2S1/eIF2-alpha also acts as an activator of mitophagy in response to mitochondrial damage: phosphorylation by EIF2AK1/HRI promotes relocalization to the mitochondrial surface, thereby triggering PRKN-independent mitophagy (PubMed:38340717)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15207627"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18032499"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19131336"}],"value":"Activity is regulated by phosphorylation at Ser-49 and Ser-52, which stabilizes the eIF2/GDP/eIF2B complex and prevents the eIF2B-mediated exchange of GDP for GTP, thereby preventing the formation of the 43S pre-initiation complex (43S PIC) (PubMed:15207627, PubMed:18032499). This results in the global attenuation of 5' cap-dependent protein synthesis and concomitant translation of ISR-specific mRNAs that contain a short upstream open reading frame (uORF) in their 5' UTR, such as ATF4, ATF5, DDIT3/CHOP and PPP1R15A/GADD34 (PubMed:19131336)"}],"commentType":"ACTIVITY REGULATION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P68101"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6ZWX6"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17894550"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18596238"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23063529"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31048492"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31836389"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35031321"}],"value":"Eukaryotic translation initiation factor 2 eIF2 is a heterotrimeric complex composed of an alpha (EIF2S1), a beta (EIF2S2) and a gamma (EIF2S3) chain (PubMed:23063529, PubMed:31048492, PubMed:31836389, PubMed:35031321). eIF2 is member of the 43S pre-initiation complex (43S PIC). eIF2 forms a complex with at least CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5 (By similarity). Interaction with METAP2 protects EIF2S1 from inhibitory phosphorylation (By similarity). Interacts with ABCF1 isoform 2 (PubMed:17894550). Associates with ribosomes (PubMed:17894550). Interacts with DDX3X in an RNA-independent manner (PubMed:18596238). Interacts with CDC123 (PubMed:31836389, PubMed:35031321)"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30258011"}],"value":"(Microbial infection) Interacts with rotavirus A non-structural protein 2; this interaction probably plays a role in the sequestration of IF2A in viral factories (PubMed:30258011). Interacts with rotavirus A non-structural protein 5; this interaction probably plays a role in its sequestration in viral factories (PubMed:30258011)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P05198","intActId":"EBI-1056162"},"interactantTwo":{"uniProtKBAccession":"P12814","geneName":"ACTN1","intActId":"EBI-351710"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P05198","intActId":"EBI-1056162"},"interactantTwo":{"uniProtKBAccession":"O00571","geneName":"DDX3X","intActId":"EBI-353779"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P05198","intActId":"EBI-1056162"},"interactantTwo":{"uniProtKBAccession":"P19525","geneName":"EIF2AK2","intActId":"EBI-640775"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P05198","intActId":"EBI-1056162"},"interactantTwo":{"uniProtKBAccession":"P20042","geneName":"EIF2S2","intActId":"EBI-711977"},"numberOfExperiments":9,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P05198","intActId":"EBI-1056162"},"interactantTwo":{"uniProtKBAccession":"P41091","geneName":"EIF2S3","intActId":"EBI-1054228"},"numberOfExperiments":9,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P05198","intActId":"EBI-1056162"},"interactantTwo":{"uniProtKBAccession":"P62136","geneName":"PPP1CA","intActId":"EBI-357253"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P05198","intActId":"EBI-1056162"},"interactantTwo":{"uniProtKBAccession":"Q9NVM4","geneName":"PRMT7","intActId":"EBI-3215577"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P05198","intActId":"EBI-1056162"},"interactantTwo":{"uniProtKBAccession":"Q08AM6","geneName":"VAC14","intActId":"EBI-2107455"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P05198","intActId":"EBI-1056162"},"interactantTwo":{"uniProtKBAccession":"Q9Z2B5","geneName":"Eif2ak3","intActId":"EBI-1226344"},"numberOfExperiments":4,"organismDiffer":true}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6ZWX6"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38340717"}],"value":"Colocalizes with NANOS3 in the stress granules (By similarity). Relocalizes to the surface of mitochondria in response to mitochondrial damage and phosphorylation by EIF2AK1/HRI (PubMed:38340717)"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6ZWX6"}],"value":"Cytoplasm, Stress granule","id":"SL-0496"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P56286"}],"value":"Cytoplasm, cytosol","id":"SL-0091"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38340717"}],"value":"Mitochondrion","id":"SL-0173"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33384352"}],"value":"Up-regulated upon endoplasmic reticulum stress"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6ZWX6"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10026192"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15207627"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18032499"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19131336"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31048492"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38340717"}],"value":"Phosphorylation at Ser-49 and Ser-52 stabilizes the eIF-2/GDP/eIF2B complex and prevents GDP/GTP exchange reaction, thus impairing the recycling of eIF-2 between successive rounds of initiation and leading to global inhibition of translation, while concomitantly initiating the preferential translation of integrated stress response (ISR)-specific mRNAs (PubMed:10026192, PubMed:15207627, PubMed:18032499, PubMed:19131336, PubMed:31048492). Substrate for at least 4 kinases: EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2 (PubMed:15489334, PubMed:38340717). Phosphorylation on Ser-52 by the EIF2AK4/GCN2 protein kinase occurs in response to amino acid starvation and UV irradiation (By similarity). Phosphorylation at Ser-52 by the EIF2AK3/PERK protein kinase occurs in response to the unfolded protein response (PubMed:10026192). Phosphorylation at Ser-52 by EIF2AK1/HRI in response to mitochondrial damage promotes relocalization to the mitochondrial surface (PubMed:38340717)"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15207627"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18032499"}],"value":"(Microbial infection) Phosphorylation by vaccinia virus protein E3 and rotavirus A stabilizes the eIF-2/GDP/eIF2B complex and prevents GDP/GTP exchange reaction, thus impairing the recycling of eIF-2 between successive rounds of initiation and leading to global inhibition of translation"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the eIF-2-alpha family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"This gene should not be confused with EIF2A, with which it shares the alias EIF2A. Although both of these proteins function in binding initiator tRNA to the 40S ribosomal subunit, the eIF2 complex requires GTP, whereas the EIF2A protein does so in a codon-dependent manner"}],"commentType":"CAUTION"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":315,"modifier":"EXACT"}},"description":"Eukaryotic translation initiation factor 2 subunit 1","featureId":"PRO_0000137382"},{"type":"Domain","location":{"start":{"value":17,"modifier":"EXACT"},"end":{"value":88,"modifier":"EXACT"}},"description":"S1 motif","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00180"}]},{"type":"Region","location":{"start":{"value":293,"modifier":"EXACT"},"end":{"value":315,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":299,"modifier":"EXACT"},"end":{"value":308,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":49,"modifier":"EXACT"},"end":{"value":49,"modifier":"EXACT"}},"description":"Phosphoserine; by HRI","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P83268"}]},{"type":"Modified residue","location":{"start":{"value":52,"modifier":"EXACT"},"end":{"value":52,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38340717"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19690332"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Modified residue","location":{"start":{"value":141,"modifier":"EXACT"},"end":{"value":141,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19608861"}]},{"type":"Modified residue","location":{"start":{"value":158,"modifier":"EXACT"},"end":{"value":158,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":279,"modifier":"EXACT"},"end":{"value":279,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":281,"modifier":"EXACT"},"end":{"value":281,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Mutagenesis","location":{"start":{"value":52,"modifier":"EXACT"},"end":{"value":52,"modifier":"EXACT"}},"description":"Abolished phosphorylation by EIF2AK1/HRI in response to stress. Abolished relocalization to the mitochondrial surface in response to mitochondrial damage.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38340717"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":52,"modifier":"EXACT"},"end":{"value":52,"modifier":"EXACT"}},"description":"Mimics phosphorylation; promotes relocalization to the mitochondrial surface in response to mitochondrial damage.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38340717"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["D"]}},{"type":"Helix","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":4,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8OZ0"}]},{"type":"Beta strand","location":{"start":{"value":8,"modifier":"EXACT"},"end":{"value":13,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1KL9"}]},{"type":"Beta strand","location":{"start":{"value":19,"modifier":"EXACT"},"end":{"value":27,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1KL9"}]},{"type":"Beta strand","location":{"start":{"value":29,"modifier":"EXACT"},"end":{"value":36,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1KL9"}]},{"type":"Turn","location":{"start":{"value":37,"modifier":"EXACT"},"end":{"value":41,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1KL9"}]},{"type":"Beta strand","location":{"start":{"value":42,"modifier":"EXACT"},"end":{"value":47,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1KL9"}]},{"type":"Helix","location":{"start":{"value":48,"modifier":"EXACT"},"end":{"value":50,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1KL9"}]},{"type":"Turn","location":{"start":{"value":55,"modifier":"EXACT"},"end":{"value":57,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6O9Z"}]},{"type":"Helix","location":{"start":{"value":59,"modifier":"EXACT"},"end":{"value":62,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8PPL"}]},{"type":"Beta strand","location":{"start":{"value":64,"modifier":"EXACT"},"end":{"value":66,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1Q8K"}]},{"type":"Beta strand","location":{"start":{"value":68,"modifier":"EXACT"},"end":{"value":77,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1KL9"}]},{"type":"Turn","location":{"start":{"value":78,"modifier":"EXACT"},"end":{"value":81,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1KL9"}]},{"type":"Beta strand","location":{"start":{"value":82,"modifier":"EXACT"},"end":{"value":87,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1KL9"}]},{"type":"Helix","location":{"start":{"value":92,"modifier":"EXACT"},"end":{"value":118,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1KL9"}]},{"type":"Helix","location":{"start":{"value":124,"modifier":"EXACT"},"end":{"value":133,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1KL9"}]},{"type":"Helix","location":{"start":{"value":135,"modifier":"EXACT"},"end":{"value":142,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1KL9"}]},{"type":"Beta strand","location":{"start":{"value":144,"modifier":"EXACT"},"end":{"value":146,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8PPL"}]},{"type":"Helix","location":{"start":{"value":147,"modifier":"EXACT"},"end":{"value":158,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1KL9"}]},{"type":"Helix","location":{"start":{"value":160,"modifier":"EXACT"},"end":{"value":163,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1KL9"}]},{"type":"Helix","location":{"start":{"value":170,"modifier":"EXACT"},"end":{"value":182,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1KL9"}]},{"type":"Beta strand","location":{"start":{"value":191,"modifier":"EXACT"},"end":{"value":196,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8PPL"}]},{"type":"Beta strand","location":{"start":{"value":198,"modifier":"EXACT"},"end":{"value":204,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8PPL"}]},{"type":"Helix","location":{"start":{"value":205,"modifier":"EXACT"},"end":{"value":217,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8PPL"}]},{"type":"Beta strand","location":{"start":{"value":218,"modifier":"EXACT"},"end":{"value":220,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1Q8K"}]},{"type":"Beta strand","location":{"start":{"value":221,"modifier":"EXACT"},"end":{"value":223,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8PPL"}]},{"type":"Beta strand","location":{"start":{"value":225,"modifier":"EXACT"},"end":{"value":228,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8PPL"}]},{"type":"Beta strand","location":{"start":{"value":230,"modifier":"EXACT"},"end":{"value":239,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8PPL"}]},{"type":"Helix","location":{"start":{"value":244,"modifier":"EXACT"},"end":{"value":261,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8PPL"}]},{"type":"Helix","location":{"start":{"value":262,"modifier":"EXACT"},"end":{"value":264,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8PPL"}]},{"type":"Beta strand","location":{"start":{"value":265,"modifier":"EXACT"},"end":{"value":268,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8PPL"}]},{"type":"Beta strand","location":{"start":{"value":269,"modifier":"EXACT"},"end":{"value":273,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8PJ4"}]},{"type":"Beta strand","location":{"start":{"value":276,"modifier":"EXACT"},"end":{"value":279,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8PPL"}]},{"type":"Helix","location":{"start":{"value":282,"modifier":"EXACT"},"end":{"value":295,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8PPL"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0007","category":"PTM","name":"Acetylation"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0396","category":"Molecular function","name":"Initiation factor"},{"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-0648","category":"Biological process","name":"Protein biosynthesis"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0694","category":"Molecular function","name":"RNA-binding"},{"id":"KW-0810","category":"Biological process","name":"Translation regulation"}],"references":[{"referenceNumber":1,"citation":{"id":"2948954","citationType":"journal article","authors":["Ernst H.","Duncan R.F.","Hershey J.W.B."],"citationCrossReferences":[{"database":"PubMed","id":"2948954"},{"database":"DOI","id":"10.1016/s0021-9258(19)75772-x"}],"title":"Cloning and sequencing of complementary DNAs encoding the alpha-subunit of translational initiation factor eIF-2. Characterization of the protein and its messenger RNA.","publicationDate":"1987","journal":"J. Biol. Chem.","firstPage":"1206","lastPage":"1212","volume":"262"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"],"referenceComments":[{"value":"Fibroblast","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Placenta","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"10026192","citationType":"journal article","authors":["Shi Y.","An J.","Liang J.","Hayes S.E.","Sandusky G.E.","Stramm L.E.","Yang N.N."],"citationCrossReferences":[{"database":"PubMed","id":"10026192"},{"database":"DOI","id":"10.1074/jbc.274.9.5723"}],"title":"Characterization of a mutant pancreatic eIF-2alpha kinase, PEK, and co-localization with somatostatin in islet delta cells.","publicationDate":"1999","journal":"J. Biol. Chem.","firstPage":"5723","lastPage":"5730","volume":"274"},"referencePositions":["PHOSPHORYLATION"]},{"referenceNumber":4,"citation":{"id":"15207627","citationType":"journal article","authors":["Langland J.O.","Jacobs B.L."],"citationCrossReferences":[{"database":"PubMed","id":"15207627"},{"database":"DOI","id":"10.1016/j.virol.2004.03.012"}],"title":"Inhibition of PKR by vaccinia virus: role of the N- and C-terminal domains of E3L.","publicationDate":"2004","journal":"Virology","firstPage":"419","lastPage":"429","volume":"324"},"referencePositions":["PHOSPHORYLATION STATE REGULATION BY VACCINIA VIRUS PROTEIN E3","ACTIVITY REGULATION"]},{"referenceNumber":5,"citation":{"id":"16289705","citationType":"journal article","authors":["Mikami S.","Masutani M.","Sonenberg N.","Yokoyama S.","Imataka H."],"citationCrossReferences":[{"database":"PubMed","id":"16289705"},{"database":"DOI","id":"10.1016/j.pep.2005.09.021"}],"title":"An efficient mammalian cell-free translation system supplemented with translation factors.","publicationDate":"2006","journal":"Protein Expr. Purif.","firstPage":"348","lastPage":"357","volume":"46"},"referencePositions":["FUNCTION"]},{"referenceNumber":6,"citation":{"id":"17894550","citationType":"journal article","authors":["Paytubi S.","Morrice N.A.","Boudeau J.","Proud C.G."],"citationCrossReferences":[{"database":"PubMed","id":"17894550"},{"database":"DOI","id":"10.1042/bj20070811"}],"title":"The N-terminal region of ABC50 interacts with eukaryotic initiation factor eIF2 and is a target for regulatory phosphorylation by CK2.","publicationDate":"2008","journal":"Biochem. J.","firstPage":"223","lastPage":"231","volume":"409"},"referencePositions":["INTERACTION WITH ABCF1","ASSOCIATION WITH RIBOSOMES"]},{"referenceNumber":7,"citation":{"id":"18032499","citationType":"journal article","authors":["Montero H.","Rojas M.","Arias C.F.","Lopez S."],"citationCrossReferences":[{"database":"PubMed","id":"18032499"},{"database":"DOI","id":"10.1128/jvi.01779-07"}],"title":"Rotavirus infection induces the phosphorylation of eIF2alpha but prevents the formation of stress granules.","publicationDate":"2008","journal":"J. Virol.","firstPage":"1496","lastPage":"1504","volume":"82"},"referencePositions":["PHOSPHORYLATION STATE REGULATION BY ROTAVIRUS A","ACTIVITY REGULATION"]},{"referenceNumber":8,"citation":{"id":"18596238","citationType":"journal article","authors":["Lai M.C.","Lee Y.H.","Tarn W.Y."],"citationCrossReferences":[{"database":"PubMed","id":"18596238"},{"database":"DOI","id":"10.1091/mbc.e07-12-1264"}],"title":"The DEAD-box RNA helicase DDX3 associates with export messenger ribonucleoproteins as well as tip-associated protein and participates in translational control.","publicationDate":"2008","journal":"Mol. Biol. Cell","firstPage":"3847","lastPage":"3858","volume":"19"},"referencePositions":["INTERACTION WITH DDX3X"]},{"referenceNumber":9,"citation":{"id":"19131336","citationType":"journal article","authors":["Lee Y.Y.","Cevallos R.C.","Jan E."],"citationCrossReferences":[{"database":"PubMed","id":"19131336"},{"database":"DOI","id":"10.1074/jbc.m806735200"}],"title":"An upstream open reading frame regulates translation of GADD34 during cellular stresses that induce eIF2alpha phosphorylation.","publicationDate":"2009","journal":"J. Biol. Chem.","firstPage":"6661","lastPage":"6673","volume":"284"},"referencePositions":["PHOSPHORYLATION","ACTIVITY REGULATION","FUNCTION"]},{"referenceNumber":10,"citation":{"id":"19690332","citationType":"journal article","authors":["Mayya V.","Lundgren D.H.","Hwang S.-I.","Rezaul K.","Wu L.","Eng J.K.","Rodionov V.","Han D.K."],"citationCrossReferences":[{"database":"PubMed","id":"19690332"},{"database":"DOI","id":"10.1126/scisignal.2000007"}],"title":"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.","publicationDate":"2009","journal":"Sci. Signal.","firstPage":"RA46","lastPage":"RA46","volume":"2"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-52","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Leukemic T-cell","type":"TISSUE"}]},{"referenceNumber":11,"citation":{"id":"19608861","citationType":"journal article","authors":["Choudhary C.","Kumar C.","Gnad F.","Nielsen M.L.","Rehman M.","Walther T.C.","Olsen J.V.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"19608861"},{"database":"DOI","id":"10.1126/science.1175371"}],"title":"Lysine acetylation targets protein complexes and co-regulates major cellular functions.","publicationDate":"2009","journal":"Science","firstPage":"834","lastPage":"840","volume":"325"},"referencePositions":["ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-141","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":12,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Buerckstuemmer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":13,"citation":{"id":"23063529","citationType":"journal article","authors":["Borck G.","Shin B.S.","Stiller B.","Mimouni-Bloch A.","Thiele H.","Kim J.R.","Thakur M.","Skinner C.","Aschenbach L.","Smirin-Yosef P.","Har-Zahav A.","Nuernberg G.","Altmueller J.","Frommolt P.","Hofmann K.","Konen O.","Nuernberg P.","Munnich A.","Schwartz C.E.","Gothelf D.","Colleaux L.","Dever T.E.","Kubisch C.","Basel-Vanagaite L."],"citationCrossReferences":[{"database":"PubMed","id":"23063529"},{"database":"DOI","id":"10.1016/j.molcel.2012.09.005"}],"title":"eIF2gamma mutation that disrupts eIF2 complex integrity links intellectual disability to impaired translation initiation.","publicationDate":"2012","journal":"Mol. Cell","firstPage":"641","lastPage":"646","volume":"48"},"referencePositions":["SUBUNIT"]},{"referenceNumber":14,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"},{"database":"DOI","id":"10.1021/pr300630k"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-158; THR-279 AND THR-281","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"},{"value":"Erythroleukemia","type":"TISSUE"}]},{"referenceNumber":15,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-52","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":16,"citation":{"id":"25944712","citationType":"journal article","authors":["Vaca Jacome A.S.","Rabilloud T.","Schaeffer-Reiss C.","Rompais M.","Ayoub D.","Lane L.","Bairoch A.","Van Dorsselaer A.","Carapito C."],"citationCrossReferences":[{"database":"PubMed","id":"25944712"},{"database":"DOI","id":"10.1002/pmic.201400617"}],"title":"N-terminome analysis of the human mitochondrial proteome.","publicationDate":"2015","journal":"Proteomics","firstPage":"2519","lastPage":"2524","volume":"15"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":17,"citation":{"id":"30258011","citationType":"journal article","authors":["Dhillon P.","Rao C.D."],"citationCrossReferences":[{"database":"PubMed","id":"30258011"},{"database":"DOI","id":"10.1128/jvi.01363-18"}],"title":"Rotavirus Induces Formation of Remodeled Stress Granules and P Bodies and Their Sequestration in Viroplasms To Promote Progeny Virus Production.","publicationDate":"2018","journal":"J. Virol.","firstPage":"0","lastPage":"0","volume":"92"},"referencePositions":["INTERACTION WITH ROTAVIRUS A NON-STRUCTURAL PROTEIN 2 (MICROBIAL INFECTION)","INTERACTION WITH ROTAVIRUS A NON-STRUCTURAL PROTEIN 5 (MICROBIAL INFECTION)"]},{"referenceNumber":18,"citation":{"id":"31836389","citationType":"journal article","authors":["Young-Baird S.K.","Lourenco M.B.","Elder M.K.","Klann E.","Liebau S.","Dever T.E."],"citationCrossReferences":[{"database":"PubMed","id":"31836389"},{"database":"DOI","id":"10.1016/j.molcel.2019.11.008"}],"title":"Suppression of MEHMO Syndrome Mutation in eIF2 by Small Molecule ISRIB.","publicationDate":"2020","journal":"Mol. Cell","firstPage":"875","lastPage":"886","volume":"77"},"referencePositions":["IDENTIFICATION IN THE EIF2 COMPLEX","INTERACTION WITH CDC123"]},{"referenceNumber":19,"citation":{"id":"33384352","citationType":"journal article","authors":["You K.","Wang L.","Chou C.H.","Liu K.","Nakata T.","Jaiswal A.","Yao J.","Lefkovith A.","Omar A.","Perrigoue J.G.","Towne J.E.","Regev A.","Graham D.B.","Xavier R.J."],"citationCrossReferences":[{"database":"PubMed","id":"33384352"},{"database":"DOI","id":"10.1126/science.abb6896"}],"title":"QRICH1 dictates the outcome of ER stress through transcriptional control of proteostasis.","publicationDate":"2021","journal":"Science","firstPage":"0","lastPage":"0","volume":"371"},"referencePositions":["FUNCTION","INDUCTION BY ER STRESS"]},{"referenceNumber":20,"citation":{"id":"35031321","citationType":"journal article","authors":["Vanselow S.","Neumann-Arnold L.","Wojciech-Moock F.","Seufert W."],"citationCrossReferences":[{"database":"PubMed","id":"35031321"},{"database":"DOI","id":"10.1016/j.jbc.2022.101583"}],"title":"Stepwise assembly of the eukaryotic translation initiation factor 2 complex.","publicationDate":"2022","journal":"J. Biol. Chem.","firstPage":"101583","lastPage":"101583","volume":"298"},"referencePositions":["IDENTIFICATION IN THE EIF2 COMPLEX","INTERACTION WITH CDC123"]},{"referenceNumber":21,"citation":{"id":"38340717","citationType":"journal article","authors":["Chakrabarty Y.","Yang Z.","Chen H.","Chan D.C."],"citationCrossReferences":[{"database":"PubMed","id":"38340717"},{"database":"DOI","id":"10.1016/j.molcel.2024.01.016"}],"title":"The HRI branch of the integrated stress response selectively triggers mitophagy.","publicationDate":"2024","journal":"Mol. Cell","firstPage":"1090","lastPage":"1100","volume":"84"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION","PHOSPHORYLATION AT SER-52","MUTAGENESIS OF SER-52"]},{"referenceNumber":22,"citation":{"id":"11859078","citationType":"journal article","authors":["Nonato M.C.","Widom J.","Clardy J."],"citationCrossReferences":[{"database":"PubMed","id":"11859078"},{"database":"DOI","id":"10.1074/jbc.m111804200"}],"title":"Crystal structure of the N-terminal segment of human eukaryotic translation initiation factor 2alpha.","publicationDate":"2002","journal":"J. Biol. Chem.","firstPage":"17057","lastPage":"17061","volume":"277"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 1-183"]},{"referenceNumber":23,"citation":{"id":"15341733","citationType":"journal article","authors":["Ito T.","Marintchev A.","Wagner G."],"citationCrossReferences":[{"database":"PubMed","id":"15341733"},{"database":"DOI","id":"10.1016/j.str.2004.07.010"}],"title":"Solution structure of human initiation factor eIF2alpha reveals homology to the elongation factor eEF1B.","publicationDate":"2004","journal":"Structure","firstPage":"1693","lastPage":"1704","volume":"12"},"referencePositions":["STRUCTURE BY NMR OF 5-303"]},{"referenceNumber":24,"citation":{"id":"31048492","citationType":"journal article","authors":["Kashiwagi K.","Yokoyama T.","Nishimoto M.","Takahashi M.","Sakamoto A.","Yonemochi M.","Shirouzu M.","Ito T."],"citationCrossReferences":[{"database":"PubMed","id":"31048492"},{"database":"DOI","id":"10.1126/science.aaw4104"}],"title":"Structural basis for eIF2B inhibition in integrated stress response.","publicationDate":"2019","journal":"Science","firstPage":"495","lastPage":"499","volume":"364"},"referencePositions":["STRUCTURE BY ELECTRON MICROSCOPY (4.30 ANGSTROMS) IN COMPLEX WITH THE EIF2B COMPLEX","IDENTIFICATION IN THE EIF2 COMPLEX","PHOSPHORYLATION"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"6K71"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6K72"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"J02645","properties":[{"key":"ProteinId","value":"AAA52373.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC002513","properties":[{"key":"ProteinId","value":"AAH02513.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS9781.1","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_004085.1","properties":[{"key":"NucleotideSequenceId","value":"NM_004094.5"}]},{"database":"PDB","id":"1KL9","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A=2-183"}]},{"database":"PDB","id":"1Q8K","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=5-303"}]},{"database":"PDB","id":"6K71","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.30 A"},{"key":"Chains","value":"K=1-315"}]},{"database":"PDB","id":"6K72","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.60 A"},{"key":"Chains","value":"K/L=1-315"}]},{"database":"PDB","id":"6O81","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.21 A"},{"key":"Chains","value":"L/M=1-315"}]},{"database":"PDB","id":"6O85","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.03 A"},{"key":"Chains","value":"L=2-315"}]},{"database":"PDB","id":"6O9Z","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.03 A"},{"key":"Chains","value":"L/M=2-315"}]},{"database":"PDB","id":"6YBV","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.80 A"},{"key":"Chains","value":"r=1-315"}]},{"database":"PDB","id":"6ZMW","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.70 A"},{"key":"Chains","value":"r=1-315"}]},{"database":"PDB","id":"6ZP4","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.90 A"},{"key":"Chains","value":"O=1-315"}]},{"database":"PDB","id":"7A09","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.50 A"},{"key":"Chains","value":"O=1-315"}]},{"database":"PDB","id":"7D43","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.30 A"},{"key":"Chains","value":"K/L=1-315"}]},{"database":"PDB","id":"7D44","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.00 A"},{"key":"Chains","value":"K/L=1-315"}]},{"database":"PDB","id":"7D45","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.80 A"},{"key":"Chains","value":"K=1-315"}]},{"database":"PDB","id":"7F66","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.76 A"},{"key":"Chains","value":"N=1-315"}]},{"database":"PDB","id":"7F67","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.59 A"},{"key":"Chains","value":"N/Q=1-315"}]},{"database":"PDB","id":"7NZM","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.96 A"},{"key":"Chains","value":"E=2-187"}]},{"database":"PDB","id":"7QP6","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.70 A"},{"key":"Chains","value":"r=1-315"}]},{"database":"PDB","id":"7QP7","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.70 A"},{"key":"Chains","value":"r=1-315"}]},{"database":"PDB","id":"7SYR","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.60 A"},{"key":"Chains","value":"j=1-315"}]},{"database":"PDB","id":"7SYS","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.50 A"},{"key":"Chains","value":"j=1-315"}]},{"database":"PDB","id":"8OZ0","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.50 A"},{"key":"Chains","value":"D=1-315"}]},{"database":"PDB","id":"8PJ1","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.40 A"},{"key":"Chains","value":"r=1-315"}]},{"database":"PDB","id":"8PJ2","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.40 A"},{"key":"Chains","value":"r=1-315"}]},{"database":"PDB","id":"8PJ3","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.70 A"},{"key":"Chains","value":"r=1-315"}]},{"database":"PDB","id":"8PJ4","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.20 A"},{"key":"Chains","value":"r=1-315"}]},{"database":"PDB","id":"8PPL","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.65 A"},{"key":"Chains","value":"Ir=1-315"}]},{"database":"PDB","id":"8QZZ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.35 A"},{"key":"Chains","value":"B=1-315"}]},{"database":"PDB","id":"9HVD","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.04 A"},{"key":"Chains","value":"K/L=1-315"}]},{"database":"PDB","id":"9HVE","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.70 A"},{"key":"Chains","value":"K/L=1-315"}]},{"database":"PDB","id":"9HVF","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.80 A"},{"key":"Chains","value":"B=1-315"}]},{"database":"PDB","id":"9NB9","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.03 A"},{"key":"Chains","value":"A=2-187"}]},{"database":"PDBsum","id":"1KL9","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1Q8K","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6K71","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6K72","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6O81","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6O85","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6O9Z","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6YBV","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6ZMW","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6ZP4","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7A09","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7D43","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7D44","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7D45","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7F66","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7F67","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7NZM","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7QP6","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7QP7","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7SYR","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7SYS","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8OZ0","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8PJ1","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8PJ2","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8PJ3","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8PJ4","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8PPL","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8QZZ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9HVD","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9HVE","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9HVF","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9NB9","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"P05198","properties":[{"key":"Description","value":"-"}]},{"database":"BMRB","id":"P05198","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-0649","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-0651","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-0664","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-10774","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-11302","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-11335","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-11602","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-12665","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-14113","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-14114","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-17297","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-17696","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-17697","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-17698","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-17699","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-17805","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-25538","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-25539","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-30568","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-30569","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-30570","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-31474","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-31475","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-49223","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-52432","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-52433","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-52434","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-9840","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-9841","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-9842","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P05198","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"108285","properties":[{"key":"Interactions","value":"308"}]},{"database":"ComplexPortal","id":"CPX-2716","properties":[{"key":"EntryName","value":"Eukaryotic translation initiation factor 2 complex"}]},{"database":"CORUM","id":"P05198","properties":[{"key":"Description","value":"-"}]},{"database":"DIP","id":"DIP-39418N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P05198","properties":[{"key":"Number of interactors","value":"2896"}]},{"database":"IntAct","id":"P05198","properties":[{"key":"Interactions","value":"127"}]},{"database":"MINT","id":"P05198","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-EIF2S1","properties":[{"key":"Evidences","value":"14 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000256383","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"P05198","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL1255131","properties":[{"key":"Description","value":"-"}]},{"database":"GlyCosmos","id":"P05198","properties":[{"key":"glycosylation","value":"4 sites, 1 glycan"}]},{"database":"GlyGen","id":"P05198","properties":[{"key":"glycosylation","value":"5 sites, 1 O-linked glycan (4 sites)"}]},{"database":"iPTMnet","id":"P05198","properties":[{"key":"Description","value":"-"}]},{"database":"MetOSite","id":"P05198","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"P05198","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"P05198","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"EIF2S1","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"124200","properties":[{"key":"Description","value":"-"}]},{"database":"OGP","id":"P05198","properties":[{"key":"Description","value":"-"}]},{"database":"REPRODUCTION-2DPAGE","id":"IPI00219678","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"P05198","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"P05198","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000256383","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P05198","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"51824","properties":[{"key":"Description","value":"-"}]},{"database":"Pumba","id":"P05198","properties":[{"key":"Description","value":"-"}]},{"database":"TopDownProteomics","id":"P05198","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"3181","properties":[{"key":"antibodies","value":"953 antibodies from 42 providers"}]},{"database":"DNASU","id":"1965","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000256383.11","properties":[{"key":"ProteinId","value":"ENSP00000256383.4"},{"key":"GeneId","value":"ENSG00000134001.16"}]},{"database":"Ensembl","id":"ENST00000466499.6","properties":[{"key":"ProteinId","value":"ENSP00000425299.1"},{"key":"GeneId","value":"ENSG00000134001.16"}]},{"database":"Ensembl","id":"ENST00000858843.1","properties":[{"key":"ProteinId","value":"ENSP00000528902.1"},{"key":"GeneId","value":"ENSG00000134001.16"}]},{"database":"Ensembl","id":"ENST00000916140.1","properties":[{"key":"ProteinId","value":"ENSP00000586199.1"},{"key":"GeneId","value":"ENSG00000134001.16"}]},{"database":"Ensembl","id":"ENST00000916141.1","properties":[{"key":"ProteinId","value":"ENSP00000586200.1"},{"key":"GeneId","value":"ENSG00000134001.16"}]},{"database":"GeneID","id":"1965","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:1965","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000256383.11","properties":[{"key":"ProteinId","value":"ENSP00000256383.4"},{"key":"RefSeqNucleotideId","value":"NM_004094.5"},{"key":"RefSeqProteinId","value":"NP_004085.1"}]},{"database":"AGR","id":"HGNC:3265","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA27695","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"1965","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"1965","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"EIF2S1","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:3265","properties":[{"key":"GeneName","value":"EIF2S1"}]},{"database":"HPA","id":"ENSG00000134001","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MIM","id":"603907","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000134001","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000134001","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG2916","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000007015","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P05198","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"DVNEHQR","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"1685042at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"P05198","properties":[{"key":"Number of GO annotations","value":"5 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"P05198","properties":[{"key":"Description","value":"-"}]},{"database":"BRENDA","id":"3.6.5.3","properties":[{"key":"OrganismId","value":"2681"}]},{"database":"PathwayCommons","id":"P05198","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-156827","properties":[{"key":"PathwayName","value":"L13a-mediated translational silencing of Ceruloplasmin expression"}]},{"database":"Reactome","id":"R-HSA-381042","properties":[{"key":"PathwayName","value":"PERK regulates gene expression"}]},{"database":"Reactome","id":"R-HSA-382556","properties":[{"key":"PathwayName","value":"ABC-family protein mediated transport"}]},{"database":"Reactome","id":"R-HSA-72649","properties":[{"key":"PathwayName","value":"Translation initiation complex formation"}]},{"database":"Reactome","id":"R-HSA-72695","properties":[{"key":"PathwayName","value":"Formation of the ternary complex, and subsequently, the 43S complex"}]},{"database":"Reactome","id":"R-HSA-72702","properties":[{"key":"PathwayName","value":"Ribosomal scanning and start codon recognition"}]},{"database":"Reactome","id":"R-HSA-72706","properties":[{"key":"PathwayName","value":"GTP hydrolysis and joining of the 60S ribosomal subunit"}]},{"database":"Reactome","id":"R-HSA-72731","properties":[{"key":"PathwayName","value":"Recycling of eIF2:GDP"}]},{"database":"Reactome","id":"R-HSA-9633012","properties":[{"key":"PathwayName","value":"Response of EIF2AK4 (GCN2) to amino acid deficiency"}]},{"database":"Reactome","id":"R-HSA-9648895","properties":[{"key":"PathwayName","value":"Response of EIF2AK1 (HRI) to heme deficiency"}]},{"database":"Reactome","id":"R-HSA-9833482","properties":[{"key":"PathwayName","value":"PKR-mediated signaling"}]},{"database":"Reactome","id":"R-HSA-9840373","properties":[{"key":"PathwayName","value":"Cellular response to mitochondrial stress"}]},{"database":"SignaLink","id":"P05198","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"P05198","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000134001","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"1965","properties":[{"key":"hits","value":"826 hits in 1137 CRISPR screens"}]},{"database":"CD-CODE","id":"91857CE7","properties":[{"key":"EntryName","value":"Nucleolus"}]},{"database":"CD-CODE","id":"DEE660B4","properties":[{"key":"EntryName","value":"Stress granule"}]},{"database":"CD-CODE","id":"FB4E32DD","properties":[{"key":"EntryName","value":"Presynaptic clusters and postsynaptic densities"}]},{"database":"EvolutionaryTrace","id":"P05198","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"EIF2S1","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"1965","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"P05198","properties":[{"key":"DevelopmentLevel","value":"Tchem"}]},{"database":"PRO","id":"PR:P05198","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 14"}]},{"database":"RNAct","id":"P05198","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000134001","properties":[{"key":"ExpressionPatterns","value":"Expressed in islet of Langerhans and 214 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"P05198","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"ISS:UniProt"}]},{"database":"GO","id":"GO:0010494","properties":[{"key":"GoTerm","value":"C:cytoplasmic stress granule"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0033290","properties":[{"key":"GoTerm","value":"C:eukaryotic 48S preinitiation complex"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0005850","properties":[{"key":"GoTerm","value":"C:eukaryotic translation initiation factor 2 complex"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"23063529"}]},{"database":"GO","id":"GO:0070062","properties":[{"key":"GoTerm","value":"C:extracellular exosome"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"20458337"}]},{"database":"GO","id":"GO:0097451","properties":[{"key":"GoTerm","value":"C:glial limiting end-foot"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"19946888"}]},{"database":"GO","id":"GO:0005739","properties":[{"key":"GoTerm","value":"C:mitochondrion"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"38340717"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0045202","properties":[{"key":"GoTerm","value":"C:synapse"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0044207","properties":[{"key":"GoTerm","value":"C:translation initiation ternary complex"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0160296","properties":[{"key":"GoTerm","value":"F:cap-dependent translation initiation factor activity"},{"key":"GoEvidenceType","value":"IDA:UniProt"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16289705"}]},{"database":"GO","id":"GO:0160297","properties":[{"key":"GoTerm","value":"F:IRES-mediated translation initiation factor activity"},{"key":"GoEvidenceType","value":"IDA:UniProt"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16289705"}]},{"database":"GO","id":"GO:0043022","properties":[{"key":"GoTerm","value":"F:ribosome binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17894550"}]},{"database":"GO","id":"GO:0003723","properties":[{"key":"GoTerm","value":"F:RNA binding"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"22658674"},{"evidenceCode":"ECO:0007005","source":"PubMed","id":"22681889"}]},{"database":"GO","id":"GO:0003743","properties":[{"key":"GoTerm","value":"F:translation initiation factor activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16289705"}]},{"database":"GO","id":"GO:0034198","properties":[{"key":"GoTerm","value":"P:cellular response to amino acid starvation"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0034605","properties":[{"key":"GoTerm","value":"P:cellular response to heat"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0034599","properties":[{"key":"GoTerm","value":"P:cellular response to oxidative stress"},{"key":"GoEvidenceType","value":"ISS:ARUK-UCL"}]},{"database":"GO","id":"GO:0034644","properties":[{"key":"GoTerm","value":"P:cellular response to UV"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0140468","properties":[{"key":"GoTerm","value":"P:HRI-mediated signaling"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"38340717"}]},{"database":"GO","id":"GO:0000423","properties":[{"key":"GoTerm","value":"P:mitophagy"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"38340717"}]},{"database":"GO","id":"GO:0032057","properties":[{"key":"GoTerm","value":"P:negative regulation of translational initiation in response to stress"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0036499","properties":[{"key":"GoTerm","value":"P:PERK-mediated unfolded protein response"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"33384352"}]},{"database":"GO","id":"GO:2000676","properties":[{"key":"GoTerm","value":"P:positive regulation of type B pancreatic cell apoptotic process"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0036490","properties":[{"key":"GoTerm","value":"P:regulation of translation in response to endoplasmic reticulum stress"},{"key":"GoEvidenceType","value":"IMP:ParkinsonsUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"18508033"}]},{"database":"GO","id":"GO:0006446","properties":[{"key":"GoTerm","value":"P:regulation of translational initiation"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"18639529"}]},{"database":"GO","id":"GO:0034976","properties":[{"key":"GoTerm","value":"P:response to endoplasmic reticulum stress"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"33384352"}]},{"database":"GO","id":"GO:1904373","properties":[{"key":"GoTerm","value":"P:response to kainic acid"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:1990737","properties":[{"key":"GoTerm","value":"P:response to manganese-induced endoplasmic reticulum stress"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0034063","properties":[{"key":"GoTerm","value":"P:stress granule assembly"},{"key":"GoEvidenceType","value":"ISS:ARUK-UCL"}]},{"database":"GO","id":"GO:0006413","properties":[{"key":"GoTerm","value":"P:translational initiation"},{"key":"GoEvidenceType","value":"IDA:UniProt"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16289705"}]},{"database":"CDD","id":"cd04452","properties":[{"key":"EntryName","value":"S1_IF2_alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.150.190:FF:000001","properties":[{"key":"EntryName","value":"Eukaryotic translation initiation factor 2 subunit 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.40.50.140:FF:000795","properties":[{"key":"EntryName","value":"Eukaryotic translation initiation factor 2 subunit 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.70.1130:FF:000001","properties":[{"key":"EntryName","value":"Eukaryotic translation initiation factor 2 subunit 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.70.1130","properties":[{"key":"EntryName","value":"EIF_2_alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.40.50.140","properties":[{"key":"EntryName","value":"Nucleic acid-binding proteins"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.150.190","properties":[{"key":"EntryName","value":"Translation initiation factor 2, subunit 1, domain 2"},{"key":"MatchStatus","value":"1"}]},{"database":"IDEAL","id":"IID00508","properties":[{"key":"Description","value":"-"}]},{"database":"InterPro","id":"IPR012340","properties":[{"key":"EntryName","value":"NA-bd_OB-fold"}]},{"database":"InterPro","id":"IPR003029","properties":[{"key":"EntryName","value":"S1_domain"}]},{"database":"InterPro","id":"IPR044126","properties":[{"key":"EntryName","value":"S1_IF2_alpha"}]},{"database":"InterPro","id":"IPR024055","properties":[{"key":"EntryName","value":"TIF2_asu_C"}]},{"database":"InterPro","id":"IPR024054","properties":[{"key":"EntryName","value":"TIF2_asu_middle_sf"}]},{"database":"InterPro","id":"IPR011488","properties":[{"key":"EntryName","value":"TIF_2_asu"}]},{"database":"PANTHER","id":"PTHR10602","properties":[{"key":"EntryName","value":"EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10602:SF0","properties":[{"key":"EntryName","value":"EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07541","properties":[{"key":"EntryName","value":"EIF_2_alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00575","properties":[{"key":"EntryName","value":"S1"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00316","properties":[{"key":"EntryName","value":"S1"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF110993","properties":[{"key":"EntryName","value":"eIF-2-alpha, C-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF116742","properties":[{"key":"EntryName","value":"eIF2alpha middle domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF50249","properties":[{"key":"EntryName","value":"Nucleic acid-binding proteins"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50126","properties":[{"key":"EntryName","value":"S1"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MPGLSCRFYQHKFPEVEDVVMVNVRSIAEMGAYVSLLEYNNIEGMILLSELSRRRIRSINKLIRIGRNECVVVIRVDKEKGYIDLSKRRVSPEEAIKCEDKFTKSKTVYSILRHVAEVLEYTKDEQLESLFQRTAWVFDDKYKRPGYGAYDAFKHAVSDPSILDSLDLNEDEREVLINNINRRLTPQAVKIRADIEVACYGYEGIDAVKEALRAGLNCSTENMPIKINLIAPPRYVMTTTTLERTEGLSVLSQAMAVIKEKIEEKRGVFNVQMEPKVVTDTDETELARQMERLERENAEVDGDDDAEEMEAKAED","length":315,"molWeight":36112,"crc64":"FF3E75E3816E6B1E","md5":"65D2039EBD4CA3143486668431506408"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"ACTIVITY REGULATION":1,"SUBUNIT":2,"INTERACTION":9,"SUBCELLULAR LOCATION":1,"INDUCTION":1,"PTM":2,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Chain":1,"Domain":1,"Region":1,"Compositional bias":1,"Modified residue":6,"Mutagenesis":2,"Helix":13,"Beta strand":17,"Turn":3},"uniParcId":"UPI000000CC43"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q53XC0","uniProtkbId":"Q53XC0_HUMAN","entryAudit":{"firstPublicDate":"2005-05-24","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2005-05-24","entryVersion":164,"sequenceVersion":1},"annotationScore":4.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAD61953.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00020950"}],"value":"Eukaryotic translation initiation factor 2 subunit 1"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00033370"}],"value":"Eukaryotic translation initiation factor 2 subunit alpha"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"EAW80933.1"}],"value":"EIF2S1"},"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"EAW80933.1"}],"value":"hCG_21909"}]}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004210"}],"value":"Cytoplasm, Stress granule","id":"SL-0496"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004514"}],"value":"Cytoplasm, cytosol","id":"SL-0091"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007223"}],"value":"Belongs to the eIF-2-alpha family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":17,"modifier":"EXACT"},"end":{"value":88,"modifier":"EXACT"}},"description":"S1 motif","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50126"}]},{"type":"Region","location":{"start":{"value":293,"modifier":"EXACT"},"end":{"value":315,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":299,"modifier":"EXACT"},"end":{"value":308,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022540"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAG35351.1"}],"id":"KW-0396","category":"Molecular function","name":"Initiation factor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022917"}],"id":"KW-0648","category":"Biological process","name":"Protein biosynthesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022884"}],"id":"KW-0694","category":"Molecular function","name":"RNA-binding"}],"references":[{"referenceNumber":1,"citation":{"id":"11181995","citationType":"journal article","authors":["Venter J.C.","Adams M.D.","Myers E.W.","Li P.W.","Mural R.J.","Sutton G.G.","Smith H.O.","Yandell M.","Evans C.A.","Holt R.A.","Gocayne J.D.","Amanatides P.","Ballew R.M.","Huson D.H.","Wortman J.R.","Zhang Q.","Kodira C.D.","Zheng X.H.","Chen L.","Skupski M.","Subramanian G.","Thomas P.D.","Zhang J.","Gabor Miklos G.L.","Nelson C.","Broder S.","Clark A.G.","Nadeau J.","McKusick V.A.","Zinder N.","Levine A.J.","Roberts R.J.","Simon M.","Slayman C.","Hunkapiller M.","Bolanos R.","Delcher A.","Dew I.","Fasulo D.","Flanigan M.","Florea L.","Halpern A.","Hannenhalli S.","Kravitz S.","Levy S.","Mobarry C.","Reinert K.","Remington K.","Abu-Threideh J.","Beasley E.","Biddick K.","Bonazzi V.","Brandon R.","Cargill M.","Chandramouliswaran I.","Charlab R.","Chaturvedi K.","Deng Z.","Di Francesco V.","Dunn P.","Eilbeck K.","Evangelista C.","Gabrielian A.E.","Gan W.","Ge W.","Gong F.","Gu Z.","Guan P.","Heiman T.J.","Higgins M.E.","Ji R.R.","Ke Z.","Ketchum K.A.","Lai Z.","Lei Y.","Li Z.","Li J.","Liang Y.","Lin X.","Lu F.","Merkulov G.V.","Milshina N.","Moore H.M.","Naik A.K.","Narayan V.A.","Neelam B.","Nusskern D.","Rusch D.B.","Salzberg S.","Shao W.","Shue B.","Sun J.","Wang Z.","Wang A.","Wang X.","Wang J.","Wei M.","Wides R.","Xiao C.","Yan C.","Yao A.","Ye J.","Zhan M.","Zhang W.","Zhang H.","Zhao Q.","Zheng L.","Zhong F.","Zhong W.","Zhu S.","Zhao S.","Gilbert D.","Baumhueter S.","Spier G.","Carter C.","Cravchik A.","Woodage T.","Ali F.","An H.","Awe A.","Baldwin D.","Baden H.","Barnstead M.","Barrow I.","Beeson K.","Busam D.","Carver A.","Center A.","Cheng M.L.","Curry L.","Danaher S.","Davenport L.","Desilets R.","Dietz S.","Dodson K.","Doup L.","Ferriera S.","Garg N.","Gluecksmann A.","Hart B.","Haynes J.","Haynes C.","Heiner C.","Hladun S.","Hostin D.","Houck J.","Howland T.","Ibegwam C.","Johnson J.","Kalush F.","Kline L.","Koduru S.","Love A.","Mann F.","May D.","McCawley S.","McIntosh T.","McMullen I.","Moy M.","Moy L.","Murphy B.","Nelson K.","Pfannkoch C.","Pratts E.","Puri V.","Qureshi H.","Reardon M.","Rodriguez R.","Rogers Y.H.","Romblad D.","Ruhfel B.","Scott R.","Sitter C.","Smallwood M.","Stewart E.","Strong R.","Suh E.","Thomas R.","Tint N.N.","Tse S.","Vech C.","Wang G.","Wetter J.","Williams S.","Williams M.","Windsor S.","Winn-Deen E.","Wolfe K.","Zaveri J.","Zaveri K.","Abril J.F.","Guigo R.","Campbell M.J.","Sjolander K.V.","Karlak B.","Kejariwal A.","Mi H.","Lazareva B.","Hatton T.","Narechania A.","Diemer K.","Muruganujan A.","Guo N.","Sato S.","Bafna V.","Istrail S.","Lippert R.","Schwartz R.","Walenz B.","Yooseph S.","Allen D.","Basu A.","Baxendale J.","Blick L.","Caminha M.","Carnes-Stine J.","Caulk P.","Chiang Y.H.","Coyne M.","Dahlke C.","Mays A.","Dombroski M.","Donnelly M.","Ely D.","Esparham S.","Fosler C.","Gire H.","Glanowski S.","Glasser K.","Glodek A.","Gorokhov M.","Graham K.","Gropman B.","Harris M.","Heil J.","Henderson S.","Hoover J.","Jennings D.","Jordan C.","Jordan J.","Kasha J.","Kagan L.","Kraft C.","Levitsky A.","Lewis M.","Liu X.","Lopez J.","Ma D.","Majoros W.","McDaniel J.","Murphy S.","Newman M.","Nguyen T.","Nguyen N.","Nodell M.","Pan S.","Peck J.","Peterson M.","Rowe W.","Sanders R.","Scott J.","Simpson M.","Smith T.","Sprague A.","Stockwell T.","Turner R.","Venter E.","Wang M.","Wen M.","Wu D.","Wu M.","Xia A.","Zandieh A.","Zhu X."],"citationCrossReferences":[{"database":"PubMed","id":"11181995"},{"database":"DOI","id":"10.1126/science.1058040"}],"title":"The sequence of the human genome.","publicationDate":"2001","journal":"Science","firstPage":"1304","lastPage":"1351","volume":"291"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"EAW80933.1"}]},{"referenceNumber":2,"citation":{"id":"CI-8O6MSMFBRPP76","citationType":"submission","authors":["Li W.B.","Gruber C.","Jessee J.","Polayes D."],"title":"Full-length cDNA libraries and normalization.","publicationDate":"JAN-2003","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAD61953.1"}],"value":"B cells","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAD61953.1"}]},{"referenceNumber":3,"citation":{"id":"CI-FIRU2ECFSA74","citationType":"submission","authors":["Genoscope"],"publicationDate":"JAN-2003","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAD61953.1"}],"value":"B cells","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAD61953.1"}]},{"referenceNumber":4,"citation":{"id":"CI-56FT96O07V0QG","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"JUL-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"EAW80933.1"}]},{"referenceNumber":5,"citation":{"id":"CI-6MEA4GF1I55C2","citationType":"submission","authors":["Wakamatsu A.","Yamamoto J.","Kimura K.","Kaida T.","Tsuchiya K.","Iida Y.","Takayama Y.","Murakawa K.","Kanehori K.","Andoh T.","Kagawa N.","Sato R.","Kawamura Y.","Tanaka S.","Kisu Y.","Sugano S.","Goshima N.","Nomura N.","Isogai T."],"title":"NEDO functional analysis of protein and research application project.","publicationDate":"JAN-2008","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAG35351.1"}],"value":"Brain","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAG35351.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AK312442","properties":[{"key":"ProteinId","value":"BAG35351.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BX161521","properties":[{"key":"ProteinId","value":"CAD61953.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"CH471061","properties":[{"key":"ProteinId","value":"EAW80933.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"NP_004085.1","properties":[{"key":"NucleotideSequenceId","value":"NM_004094.5"}]},{"database":"AlphaFoldDB","id":"Q53XC0","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q53XC0","properties":[{"key":"Description","value":"-"}]},{"database":"IntAct","id":"Q53XC0","properties":[{"key":"Interactions","value":"1"}]},{"database":"SwissPalm","id":"Q53XC0","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"3181","properties":[{"key":"antibodies","value":"953 antibodies from 42 providers"}]},{"database":"DNASU","id":"1965","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"1965","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:1965","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc001xjg.4","properties":[{"key":"OrganismName","value":"human"}]},{"database":"ClinPGx","id":"PA27695","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"1965","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"1965","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000134001","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"DVNEHQR","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"1685042at2759","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"1965","properties":[{"key":"hits","value":"826 hits in 1137 CRISPR screens"}]},{"database":"ExpressionAtlas","id":"Q53XC0","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"ISS:AgBase"}]},{"database":"GO","id":"GO:0010494","properties":[{"key":"GoTerm","value":"C:cytoplasmic stress granule"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005850","properties":[{"key":"GoTerm","value":"C:eukaryotic translation initiation factor 2 complex"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0097451","properties":[{"key":"GoTerm","value":"C:glial limiting end-foot"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0045202","properties":[{"key":"GoTerm","value":"C:synapse"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0044207","properties":[{"key":"GoTerm","value":"C:translation initiation ternary complex"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0003723","properties":[{"key":"GoTerm","value":"F:RNA binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0003743","properties":[{"key":"GoTerm","value":"F:translation initiation factor activity"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0034198","properties":[{"key":"GoTerm","value":"P:cellular response to amino acid starvation"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0034605","properties":[{"key":"GoTerm","value":"P:cellular response to heat"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0034599","properties":[{"key":"GoTerm","value":"P:cellular response to oxidative stress"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0034644","properties":[{"key":"GoTerm","value":"P:cellular response to UV"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0032057","properties":[{"key":"GoTerm","value":"P:negative regulation of translational initiation in response to stress"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:2000676","properties":[{"key":"GoTerm","value":"P:positive regulation of type B pancreatic cell apoptotic process"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:1904373","properties":[{"key":"GoTerm","value":"P:response to kainic acid"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:1990737","properties":[{"key":"GoTerm","value":"P:response to manganese-induced endoplasmic reticulum stress"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0034063","properties":[{"key":"GoTerm","value":"P:stress granule assembly"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"CDD","id":"cd04452","properties":[{"key":"EntryName","value":"S1_IF2_alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.150.190:FF:000001","properties":[{"key":"EntryName","value":"Eukaryotic translation initiation factor 2 subunit 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.40.50.140:FF:000795","properties":[{"key":"EntryName","value":"Eukaryotic translation initiation factor 2 subunit 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.70.1130:FF:000001","properties":[{"key":"EntryName","value":"Eukaryotic translation initiation factor 2 subunit 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.70.1130","properties":[{"key":"EntryName","value":"EIF_2_alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.40.50.140","properties":[{"key":"EntryName","value":"Nucleic acid-binding proteins"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.150.190","properties":[{"key":"EntryName","value":"Translation initiation factor 2, subunit 1, domain 2"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR012340","properties":[{"key":"EntryName","value":"NA-bd_OB-fold"}]},{"database":"InterPro","id":"IPR003029","properties":[{"key":"EntryName","value":"S1_domain"}]},{"database":"InterPro","id":"IPR044126","properties":[{"key":"EntryName","value":"S1_IF2_alpha"}]},{"database":"InterPro","id":"IPR024055","properties":[{"key":"EntryName","value":"TIF2_asu_C"}]},{"database":"InterPro","id":"IPR024054","properties":[{"key":"EntryName","value":"TIF2_asu_middle_sf"}]},{"database":"InterPro","id":"IPR011488","properties":[{"key":"EntryName","value":"TIF_2_asu"}]},{"database":"PANTHER","id":"PTHR10602","properties":[{"key":"EntryName","value":"EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10602:SF0","properties":[{"key":"EntryName","value":"EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07541","properties":[{"key":"EntryName","value":"EIF_2_alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00575","properties":[{"key":"EntryName","value":"S1"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00316","properties":[{"key":"EntryName","value":"S1"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF110993","properties":[{"key":"EntryName","value":"eIF-2-alpha, C-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF116742","properties":[{"key":"EntryName","value":"eIF2alpha middle domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF50249","properties":[{"key":"EntryName","value":"Nucleic acid-binding proteins"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50126","properties":[{"key":"EntryName","value":"S1"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MPGLSCRFYQHKFPEVEDVVMVNVRSIAEMGAYVSLLEYNNIEGMILLSELSRRRIRSINKLIRIGRNECVVVIRVDKEKGYIDLSKRRVSPEEAIKCEDKFTKSKTVYSILRHVAEVLEYTKDEQLESLFQRTAWVFDDKYKRPGYGAYDAFKHAVSDPSILDSLDLNEDEREVLINNINRRLTPQAVKIRADIEVACYGYEGIDAVKEALRAGLNCSTENMPIKINLIAPPRYVMTTTTLERTEGLSVLSQAMAVIKEKIEEKRGVFNVQMEPKVVTDTDETELARQMERLERENAEVDGDDDAEEMEAKAED","length":315,"molWeight":36112,"crc64":"FF3E75E3816E6B1E","md5":"65D2039EBD4CA3143486668431506408"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Domain":1,"Region":1,"Compositional bias":1},"uniParcId":"UPI000000CC43"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8QAE4","uniProtkbId":"A0ACI8QAE4_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000528904.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00020950"}],"value":"Eukaryotic translation initiation factor 2 subunit 1"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00033370"}],"value":"Eukaryotic translation initiation factor 2 subunit alpha"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000528904.1"}],"value":"EIF2S1"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004210"}],"value":"Cytoplasm, Stress granule","id":"SL-0496"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004514"}],"value":"Cytoplasm, cytosol","id":"SL-0091"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007223"}],"value":"Belongs to the eIF-2-alpha family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":17,"modifier":"EXACT"},"end":{"value":88,"modifier":"EXACT"}},"description":"S1 motif","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50126"}]},{"type":"Region","location":{"start":{"value":330,"modifier":"EXACT"},"end":{"value":352,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":336,"modifier":"EXACT"},"end":{"value":345,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022540"}],"id":"KW-0396","category":"Molecular function","name":"Initiation factor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022917"}],"id":"KW-0648","category":"Biological process","name":"Protein biosynthesis"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8QAE4"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8QAE4"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022884"}],"id":"KW-0694","category":"Molecular function","name":"RNA-binding"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000528904.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"12508121","citationType":"journal article","authors":["Heilig R.","Eckenberg R.","Petit J.L.","Fonknechten N.","Da Silva C.","Cattolico L.","Levy M.","Barbe V.","de Berardinis V.","Ureta-Vidal A.","Pelletier E.","Vico V.","Anthouard V.","Rowen L.","Madan A.","Qin S.","Sun H.","Du H.","Pepin K.","Artiguenave F.","Robert C.","Cruaud C.","Bruls T.","Jaillon O.","Friedlander L.","Samson G.","Brottier P.","Cure S.","Segurens B.","Aniere F.","Samain S.","Crespeau H.","Abbasi N.","Aiach N.","Boscus D.","Dickhoff R.","Dors M.","Dubois I.","Friedman C.","Gouyvenoux M.","James R.","Madan A.","Mairey-Estrada B.","Mangenot S.","Martins N.","Menard M.","Oztas S.","Ratcliffe A.","Shaffer T.","Trask B.","Vacherie B.","Bellemere C.","Belser C.","Besnard-Gonnet M.","Bartol-Mavel D.","Boutard M.","Briez-Silla S.","Combette S.","Dufosse-Laurent V.","Ferron C.","Lechaplais C.","Louesse C.","Muselet D.","Magdelenat G.","Pateau E.","Petit E.","Sirvain-Trukniewicz P.","Trybou A.","Vega-Czarny N.","Bataille E.","Bluet E.","Bordelais I.","Dubois M.","Dumont C.","Guerin T.","Haffray S.","Hammadi R.","Muanga J.","Pellouin V.","Robert D.","Wunderle E.","Gauguet G.","Roy A.","Sainte-Marthe L.","Verdier J.","Verdier-Discala C.","Hillier L.","Fulton L.","McPherson J.","Matsuda F.","Wilson R.","Scarpelli C.","Gyapay G.","Wincker P.","Saurin W.","Quetier F.","Waterston R.","Hood L.","Weissenbach J."],"citationCrossReferences":[{"database":"PubMed","id":"12508121"},{"database":"DOI","id":"10.1038/nature01348"}],"title":"The DNA sequence and analysis of human chromosome 14.","publicationDate":"2003","journal":"Nature","firstPage":"601","lastPage":"607","volume":"421"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000528904.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000528904.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000528904.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL139785","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000858845.1","properties":[{"key":"ProteinId","value":"ENSP00000528904.1"},{"key":"GeneId","value":"ENSG00000134001.16"}]},{"database":"HGNC","id":"HGNC:3265","properties":[{"key":"GeneName","value":"EIF2S1"}]},{"database":"OpenTargets","id":"ENSG00000134001","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00390000007015","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 14"}]},{"database":"CDD","id":"cd04452","properties":[{"key":"EntryName","value":"S1_IF2_alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.150.190:FF:000001","properties":[{"key":"EntryName","value":"Eukaryotic translation initiation factor 2 subunit 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.40.50.140:FF:000795","properties":[{"key":"EntryName","value":"Eukaryotic translation initiation factor 2 subunit 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.70.1130:FF:000001","properties":[{"key":"EntryName","value":"Eukaryotic translation initiation factor 2 subunit 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.70.1130","properties":[{"key":"EntryName","value":"EIF_2_alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.40.50.140","properties":[{"key":"EntryName","value":"Nucleic acid-binding proteins"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.150.190","properties":[{"key":"EntryName","value":"Translation initiation factor 2, subunit 1, domain 2"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR012340","properties":[{"key":"EntryName","value":"NA-bd_OB-fold"}]},{"database":"InterPro","id":"IPR003029","properties":[{"key":"EntryName","value":"S1_domain"}]},{"database":"InterPro","id":"IPR044126","properties":[{"key":"EntryName","value":"S1_IF2_alpha"}]},{"database":"InterPro","id":"IPR024055","properties":[{"key":"EntryName","value":"TIF2_asu_C"}]},{"database":"InterPro","id":"IPR024054","properties":[{"key":"EntryName","value":"TIF2_asu_middle_sf"}]},{"database":"InterPro","id":"IPR011488","properties":[{"key":"EntryName","value":"TIF_2_asu"}]},{"database":"PANTHER","id":"PTHR10602","properties":[{"key":"EntryName","value":"EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10602:SF0","properties":[{"key":"EntryName","value":"EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07541","properties":[{"key":"EntryName","value":"EIF_2_alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00575","properties":[{"key":"EntryName","value":"S1"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00316","properties":[{"key":"EntryName","value":"S1"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF110993","properties":[{"key":"EntryName","value":"eIF-2-alpha, C-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF116742","properties":[{"key":"EntryName","value":"eIF2alpha middle domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF50249","properties":[{"key":"EntryName","value":"Nucleic acid-binding proteins"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50126","properties":[{"key":"EntryName","value":"S1"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MPGLSCRFYQHKFPEVEDVVMVNVRSIAEMGAYVSLLEYNNIEGMILLSELSRRRIRSINKLIRIGRNECVVVIRVDKEKGYIDLSKRRVSPEEAIKCEDKFTKSKTSFPDWSVVAQSQLTATTSSWAQAILSPLPPGMFEITGVYSILRHVAEVLEYTKDEQLESLFQRTAWVFDDKYKRPGYGAYDAFKHAVSDPSILDSLDLNEDEREVLINNINRRLTPQAVKIRADIEVACYGYEGIDAVKEALRAGLNCSTENMPIKINLIAPPRYVMTTTTLERTEGLSVLSQAMAVIKEKIEEKRGVFNVQMEPKVVTDTDETELARQMERLERENAEVDGDDDAEEMEAKAED","length":352,"molWeight":40017,"crc64":"ACCA7DE47A6C2B84","md5":"A37967F1A393C8A60E2DE15CDA96E111"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Domain":1,"Region":1,"Compositional bias":1},"uniParcId":"UPI0040318460"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8R1D3","uniProtkbId":"A0ACI8R1D3_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000528905.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00020950"}],"value":"Eukaryotic translation initiation factor 2 subunit 1"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00033370"}],"value":"Eukaryotic translation initiation factor 2 subunit alpha"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000528905.1"}],"value":"EIF2S1"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004210"}],"value":"Cytoplasm, Stress granule","id":"SL-0496"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007223"}],"value":"Belongs to the eIF-2-alpha family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":17,"modifier":"EXACT"},"end":{"value":88,"modifier":"EXACT"}},"description":"S1 motif","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50126"}]},{"type":"Region","location":{"start":{"value":276,"modifier":"EXACT"},"end":{"value":298,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":282,"modifier":"EXACT"},"end":{"value":291,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022540"}],"id":"KW-0396","category":"Molecular function","name":"Initiation factor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022917"}],"id":"KW-0648","category":"Biological process","name":"Protein biosynthesis"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8R1D3"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8R1D3"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000528905.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"12508121","citationType":"journal article","authors":["Heilig R.","Eckenberg R.","Petit J.L.","Fonknechten N.","Da Silva C.","Cattolico L.","Levy M.","Barbe V.","de Berardinis V.","Ureta-Vidal A.","Pelletier E.","Vico V.","Anthouard V.","Rowen L.","Madan A.","Qin S.","Sun H.","Du H.","Pepin K.","Artiguenave F.","Robert C.","Cruaud C.","Bruls T.","Jaillon O.","Friedlander L.","Samson G.","Brottier P.","Cure S.","Segurens B.","Aniere F.","Samain S.","Crespeau H.","Abbasi N.","Aiach N.","Boscus D.","Dickhoff R.","Dors M.","Dubois I.","Friedman C.","Gouyvenoux M.","James R.","Madan A.","Mairey-Estrada B.","Mangenot S.","Martins N.","Menard M.","Oztas S.","Ratcliffe A.","Shaffer T.","Trask B.","Vacherie B.","Bellemere C.","Belser C.","Besnard-Gonnet M.","Bartol-Mavel D.","Boutard M.","Briez-Silla S.","Combette S.","Dufosse-Laurent V.","Ferron C.","Lechaplais C.","Louesse C.","Muselet D.","Magdelenat G.","Pateau E.","Petit E.","Sirvain-Trukniewicz P.","Trybou A.","Vega-Czarny N.","Bataille E.","Bluet E.","Bordelais I.","Dubois M.","Dumont C.","Guerin T.","Haffray S.","Hammadi R.","Muanga J.","Pellouin V.","Robert D.","Wunderle E.","Gauguet G.","Roy A.","Sainte-Marthe L.","Verdier J.","Verdier-Discala C.","Hillier L.","Fulton L.","McPherson J.","Matsuda F.","Wilson R.","Scarpelli C.","Gyapay G.","Wincker P.","Saurin W.","Quetier F.","Waterston R.","Hood L.","Weissenbach J."],"citationCrossReferences":[{"database":"PubMed","id":"12508121"},{"database":"DOI","id":"10.1038/nature01348"}],"title":"The DNA sequence and analysis of human chromosome 14.","publicationDate":"2003","journal":"Nature","firstPage":"601","lastPage":"607","volume":"421"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000528905.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000528905.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000528905.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL139785","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000858846.1","properties":[{"key":"ProteinId","value":"ENSP00000528905.1"},{"key":"GeneId","value":"ENSG00000134001.16"}]},{"database":"HGNC","id":"HGNC:3265","properties":[{"key":"GeneName","value":"EIF2S1"}]},{"database":"OpenTargets","id":"ENSG00000134001","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00390000007015","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 14"}]},{"database":"CDD","id":"cd04452","properties":[{"key":"EntryName","value":"S1_IF2_alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.40.50.140:FF:000795","properties":[{"key":"EntryName","value":"Eukaryotic translation initiation factor 2 subunit 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.70.1130:FF:000001","properties":[{"key":"EntryName","value":"Eukaryotic translation initiation factor 2 subunit 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.70.1130","properties":[{"key":"EntryName","value":"EIF_2_alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.40.50.140","properties":[{"key":"EntryName","value":"Nucleic acid-binding proteins"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.150.190","properties":[{"key":"EntryName","value":"Translation initiation factor 2, subunit 1, domain 2"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR012340","properties":[{"key":"EntryName","value":"NA-bd_OB-fold"}]},{"database":"InterPro","id":"IPR003029","properties":[{"key":"EntryName","value":"S1_domain"}]},{"database":"InterPro","id":"IPR044126","properties":[{"key":"EntryName","value":"S1_IF2_alpha"}]},{"database":"InterPro","id":"IPR024055","properties":[{"key":"EntryName","value":"TIF2_asu_C"}]},{"database":"InterPro","id":"IPR024054","properties":[{"key":"EntryName","value":"TIF2_asu_middle_sf"}]},{"database":"InterPro","id":"IPR011488","properties":[{"key":"EntryName","value":"TIF_2_asu"}]},{"database":"PANTHER","id":"PTHR10602","properties":[{"key":"EntryName","value":"EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10602:SF0","properties":[{"key":"EntryName","value":"EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07541","properties":[{"key":"EntryName","value":"EIF_2_alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00575","properties":[{"key":"EntryName","value":"S1"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00316","properties":[{"key":"EntryName","value":"S1"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF110993","properties":[{"key":"EntryName","value":"eIF-2-alpha, C-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF116742","properties":[{"key":"EntryName","value":"eIF2alpha middle domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF50249","properties":[{"key":"EntryName","value":"Nucleic acid-binding proteins"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50126","properties":[{"key":"EntryName","value":"S1"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MPGLSCRFYQHKFPEVEDVVMVNVRSIAEMGAYVSLLEYNNIEGMILLSELSRRRIRSINKLIRIGRNECVVVIRVDKEKGYIDLSKRRVSPEEAIKCEDKFTKSKTVYSILRHVAEVLEYTKDEQLESLFQRTAWVFDDKDPSILDSLDLNEDEREVLINNINRRLTPQAVKIRADIEVACYGYEGIDAVKEALRAGLNCSTENMPIKINLIAPPRYVMTTTTLERTEGLSVLSQAMAVIKEKIEEKRGVFNVQMEPKVVTDTDETELARQMERLERENAEVDGDDDAEEMEAKAED","length":298,"molWeight":34200,"crc64":"97D4EC5B945D5889","md5":"E4CBE105825C3658579AB75958DF6611"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Domain":1,"Region":1,"Compositional bias":1},"uniParcId":"UPI0040326417"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8UKV9","uniProtkbId":"A0ACI8UKV9_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000620643.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00020950"}],"value":"Eukaryotic translation initiation factor 2 subunit 1"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00033370"}],"value":"Eukaryotic translation initiation factor 2 subunit alpha"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000620643.1"}],"value":"EIF2S1"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004210"}],"value":"Cytoplasm, Stress granule","id":"SL-0496"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004514"}],"value":"Cytoplasm, cytosol","id":"SL-0091"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007223"}],"value":"Belongs to the eIF-2-alpha family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":17,"modifier":"EXACT"},"end":{"value":88,"modifier":"EXACT"}},"description":"S1 motif","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50126"}]},{"type":"Region","location":{"start":{"value":306,"modifier":"EXACT"},"end":{"value":329,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":313,"modifier":"EXACT"},"end":{"value":322,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022540"}],"id":"KW-0396","category":"Molecular function","name":"Initiation factor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022917"}],"id":"KW-0648","category":"Biological process","name":"Protein biosynthesis"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8UKV9"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8UKV9"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022884"}],"id":"KW-0694","category":"Molecular function","name":"RNA-binding"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000620643.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"12508121","citationType":"journal article","authors":["Heilig R.","Eckenberg R.","Petit J.L.","Fonknechten N.","Da Silva C.","Cattolico L.","Levy M.","Barbe V.","de Berardinis V.","Ureta-Vidal A.","Pelletier E.","Vico V.","Anthouard V.","Rowen L.","Madan A.","Qin S.","Sun H.","Du H.","Pepin K.","Artiguenave F.","Robert C.","Cruaud C.","Bruls T.","Jaillon O.","Friedlander L.","Samson G.","Brottier P.","Cure S.","Segurens B.","Aniere F.","Samain S.","Crespeau H.","Abbasi N.","Aiach N.","Boscus D.","Dickhoff R.","Dors M.","Dubois I.","Friedman C.","Gouyvenoux M.","James R.","Madan A.","Mairey-Estrada B.","Mangenot S.","Martins N.","Menard M.","Oztas S.","Ratcliffe A.","Shaffer T.","Trask B.","Vacherie B.","Bellemere C.","Belser C.","Besnard-Gonnet M.","Bartol-Mavel D.","Boutard M.","Briez-Silla S.","Combette S.","Dufosse-Laurent V.","Ferron C.","Lechaplais C.","Louesse C.","Muselet D.","Magdelenat G.","Pateau E.","Petit E.","Sirvain-Trukniewicz P.","Trybou A.","Vega-Czarny N.","Bataille E.","Bluet E.","Bordelais I.","Dubois M.","Dumont C.","Guerin T.","Haffray S.","Hammadi R.","Muanga J.","Pellouin V.","Robert D.","Wunderle E.","Gauguet G.","Roy A.","Sainte-Marthe L.","Verdier J.","Verdier-Discala C.","Hillier L.","Fulton L.","McPherson J.","Matsuda F.","Wilson R.","Scarpelli C.","Gyapay G.","Wincker P.","Saurin W.","Quetier F.","Waterston R.","Hood L.","Weissenbach J."],"citationCrossReferences":[{"database":"PubMed","id":"12508121"},{"database":"DOI","id":"10.1038/nature01348"}],"title":"The DNA sequence and analysis of human chromosome 14.","publicationDate":"2003","journal":"Nature","firstPage":"601","lastPage":"607","volume":"421"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000620643.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000620643.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000620643.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL139785","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000950584.1","properties":[{"key":"ProteinId","value":"ENSP00000620643.1"},{"key":"GeneId","value":"ENSG00000134001.16"}]},{"database":"HGNC","id":"HGNC:3265","properties":[{"key":"GeneName","value":"EIF2S1"}]},{"database":"OpenTargets","id":"ENSG00000134001","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00390000007015","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 14"}]},{"database":"CDD","id":"cd04452","properties":[{"key":"EntryName","value":"S1_IF2_alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.150.190:FF:000001","properties":[{"key":"EntryName","value":"Eukaryotic translation initiation factor 2 subunit 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.40.50.140:FF:000795","properties":[{"key":"EntryName","value":"Eukaryotic translation initiation factor 2 subunit 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.70.1130:FF:000001","properties":[{"key":"EntryName","value":"Eukaryotic translation initiation factor 2 subunit 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.70.1130","properties":[{"key":"EntryName","value":"EIF_2_alpha"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"2.40.50.140","properties":[{"key":"EntryName","value":"Nucleic acid-binding proteins"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.150.190","properties":[{"key":"EntryName","value":"Translation initiation factor 2, subunit 1, domain 2"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR012340","properties":[{"key":"EntryName","value":"NA-bd_OB-fold"}]},{"database":"InterPro","id":"IPR003029","properties":[{"key":"EntryName","value":"S1_domain"}]},{"database":"InterPro","id":"IPR044126","properties":[{"key":"EntryName","value":"S1_IF2_alpha"}]},{"database":"InterPro","id":"IPR024055","properties":[{"key":"EntryName","value":"TIF2_asu_C"}]},{"database":"InterPro","id":"IPR024054","properties":[{"key":"EntryName","value":"TIF2_asu_middle_sf"}]},{"database":"InterPro","id":"IPR011488","properties":[{"key":"EntryName","value":"TIF_2_asu"}]},{"database":"PANTHER","id":"PTHR10602","properties":[{"key":"EntryName","value":"EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10602:SF0","properties":[{"key":"EntryName","value":"EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07541","properties":[{"key":"EntryName","value":"EIF_2_alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00575","properties":[{"key":"EntryName","value":"S1"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00316","properties":[{"key":"EntryName","value":"S1"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF110993","properties":[{"key":"EntryName","value":"eIF-2-alpha, C-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF116742","properties":[{"key":"EntryName","value":"eIF2alpha middle domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF50249","properties":[{"key":"EntryName","value":"Nucleic acid-binding proteins"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50126","properties":[{"key":"EntryName","value":"S1"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MPGLSCRFYQHKFPEVEDVVMVNVRSIAEMGAYVSLLEYNNIEGMILLSELSRRRIRSINKLIRIGRNECVVVIRVDKEKGYIDLSKRRVSPEEAIKCEDKFTKSKTVYSILRHVAEVLEYTKDEQLESLFQRTAWVFDDKYKRPGYGAYDAFKHAVSDPSILDSLDLNEDEREVLINNINRRLTPQAVKIRADIEVACYGYEGIDAVKEALRAGLNCSTENMPIKINLIAPPRYVMTTTTLERTEGLSVLSQAMAVIKEKIEEKRGVFNVQMEYLLLQFEIIPLLPQPKVVTDTDETELARQMERLERENAEVDGDDDAEEMEAKAED","length":329,"molWeight":37794,"crc64":"8C1C9ACA665FC5AF","md5":"865008973F7B6ACF656EE280C9D6599C"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Domain":1,"Region":1,"Compositional bias":1},"uniParcId":"UPI0040318F8D"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8PLZ8","uniProtkbId":"A0ACI8PLZ8_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000528903.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00020950"}],"value":"Eukaryotic translation initiation factor 2 subunit 1"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00033370"}],"value":"Eukaryotic translation initiation factor 2 subunit alpha"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000528903.1"}],"value":"EIF2S1"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004210"}],"value":"Cytoplasm, Stress granule","id":"SL-0496"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004514"}],"value":"Cytoplasm, cytosol","id":"SL-0091"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007223"}],"value":"Belongs to the eIF-2-alpha family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":17,"modifier":"EXACT"},"end":{"value":98,"modifier":"EXACT"}},"description":"S1 motif","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50126"}]},{"type":"Region","location":{"start":{"value":303,"modifier":"EXACT"},"end":{"value":325,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":309,"modifier":"EXACT"},"end":{"value":318,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022540"}],"id":"KW-0396","category":"Molecular function","name":"Initiation factor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022917"}],"id":"KW-0648","category":"Biological process","name":"Protein biosynthesis"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8PLZ8"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8PLZ8"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022884"}],"id":"KW-0694","category":"Molecular function","name":"RNA-binding"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000528903.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"12508121","citationType":"journal article","authors":["Heilig R.","Eckenberg R.","Petit J.L.","Fonknechten N.","Da Silva C.","Cattolico L.","Levy M.","Barbe V.","de Berardinis V.","Ureta-Vidal A.","Pelletier E.","Vico V.","Anthouard V.","Rowen L.","Madan A.","Qin S.","Sun H.","Du H.","Pepin K.","Artiguenave F.","Robert C.","Cruaud C.","Bruls T.","Jaillon O.","Friedlander L.","Samson G.","Brottier P.","Cure S.","Segurens B.","Aniere F.","Samain S.","Crespeau H.","Abbasi N.","Aiach N.","Boscus D.","Dickhoff R.","Dors M.","Dubois I.","Friedman C.","Gouyvenoux M.","James R.","Madan A.","Mairey-Estrada B.","Mangenot S.","Martins N.","Menard M.","Oztas S.","Ratcliffe A.","Shaffer T.","Trask B.","Vacherie B.","Bellemere C.","Belser C.","Besnard-Gonnet M.","Bartol-Mavel D.","Boutard M.","Briez-Silla S.","Combette S.","Dufosse-Laurent V.","Ferron C.","Lechaplais C.","Louesse C.","Muselet D.","Magdelenat G.","Pateau E.","Petit E.","Sirvain-Trukniewicz P.","Trybou A.","Vega-Czarny N.","Bataille E.","Bluet E.","Bordelais I.","Dubois M.","Dumont C.","Guerin T.","Haffray S.","Hammadi R.","Muanga J.","Pellouin V.","Robert D.","Wunderle E.","Gauguet G.","Roy A.","Sainte-Marthe L.","Verdier J.","Verdier-Discala C.","Hillier L.","Fulton L.","McPherson J.","Matsuda F.","Wilson R.","Scarpelli C.","Gyapay G.","Wincker P.","Saurin W.","Quetier F.","Waterston R.","Hood L.","Weissenbach J."],"citationCrossReferences":[{"database":"PubMed","id":"12508121"},{"database":"DOI","id":"10.1038/nature01348"}],"title":"The DNA sequence and analysis of human chromosome 14.","publicationDate":"2003","journal":"Nature","firstPage":"601","lastPage":"607","volume":"421"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000528903.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000528903.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000528903.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL139785","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000858844.1","properties":[{"key":"ProteinId","value":"ENSP00000528903.1"},{"key":"GeneId","value":"ENSG00000134001.16"}]},{"database":"HGNC","id":"HGNC:3265","properties":[{"key":"GeneName","value":"EIF2S1"}]},{"database":"OpenTargets","id":"ENSG00000134001","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00390000007015","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 14"}]},{"database":"CDD","id":"cd04452","properties":[{"key":"EntryName","value":"S1_IF2_alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.150.190:FF:000001","properties":[{"key":"EntryName","value":"Eukaryotic translation initiation factor 2 subunit 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.40.50.140:FF:000795","properties":[{"key":"EntryName","value":"Eukaryotic translation initiation factor 2 subunit 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.70.1130:FF:000001","properties":[{"key":"EntryName","value":"Eukaryotic translation initiation factor 2 subunit 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.70.1130","properties":[{"key":"EntryName","value":"EIF_2_alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.40.50.140","properties":[{"key":"EntryName","value":"Nucleic acid-binding proteins"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.150.190","properties":[{"key":"EntryName","value":"Translation initiation factor 2, subunit 1, domain 2"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR012340","properties":[{"key":"EntryName","value":"NA-bd_OB-fold"}]},{"database":"InterPro","id":"IPR003029","properties":[{"key":"EntryName","value":"S1_domain"}]},{"database":"InterPro","id":"IPR044126","properties":[{"key":"EntryName","value":"S1_IF2_alpha"}]},{"database":"InterPro","id":"IPR024055","properties":[{"key":"EntryName","value":"TIF2_asu_C"}]},{"database":"InterPro","id":"IPR024054","properties":[{"key":"EntryName","value":"TIF2_asu_middle_sf"}]},{"database":"InterPro","id":"IPR011488","properties":[{"key":"EntryName","value":"TIF_2_asu"}]},{"database":"PANTHER","id":"PTHR10602","properties":[{"key":"EntryName","value":"EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10602:SF0","properties":[{"key":"EntryName","value":"EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07541","properties":[{"key":"EntryName","value":"EIF_2_alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00575","properties":[{"key":"EntryName","value":"S1"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00316","properties":[{"key":"EntryName","value":"S1"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF110993","properties":[{"key":"EntryName","value":"eIF-2-alpha, C-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF116742","properties":[{"key":"EntryName","value":"eIF2alpha middle domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF50249","properties":[{"key":"EntryName","value":"Nucleic acid-binding proteins"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50126","properties":[{"key":"EntryName","value":"S1"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MPGLSCRFYQHKFPEVEDVVMVNVRSIAEMGAYVSLLEYNNIEGMILLSELSRRRIRSINKLIRIGRNECVVVIRVDKEKEMIFSQFFCTGYIDLSKRRVSPEEAIKCEDKFTKSKTVYSILRHVAEVLEYTKDEQLESLFQRTAWVFDDKYKRPGYGAYDAFKHAVSDPSILDSLDLNEDEREVLINNINRRLTPQAVKIRADIEVACYGYEGIDAVKEALRAGLNCSTENMPIKINLIAPPRYVMTTTTLERTEGLSVLSQAMAVIKEKIEEKRGVFNVQMEPKVVTDTDETELARQMERLERENAEVDGDDDAEEMEAKAED","length":325,"molWeight":37347,"crc64":"6B83F9B380B10846","md5":"749034099CF2047D0FF06AB4F8581B10"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Domain":1,"Region":1,"Compositional bias":1},"uniParcId":"UPI0040316195"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8QVR9","uniProtkbId":"A0ACI8QVR9_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000528901.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00020950"}],"value":"Eukaryotic translation initiation factor 2 subunit 1"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00033370"}],"value":"Eukaryotic translation initiation factor 2 subunit alpha"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000528901.1"}],"value":"EIF2S1"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004210"}],"value":"Cytoplasm, Stress granule","id":"SL-0496"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004514"}],"value":"Cytoplasm, cytosol","id":"SL-0091"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007223"}],"value":"Belongs to the eIF-2-alpha family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":17,"modifier":"EXACT"},"end":{"value":88,"modifier":"EXACT"}},"description":"S1 motif","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50126"}]},{"type":"Region","location":{"start":{"value":286,"modifier":"EXACT"},"end":{"value":308,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":292,"modifier":"EXACT"},"end":{"value":301,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022540"}],"id":"KW-0396","category":"Molecular function","name":"Initiation factor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022917"}],"id":"KW-0648","category":"Biological process","name":"Protein biosynthesis"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8QVR9"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8QVR9"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022884"}],"id":"KW-0694","category":"Molecular function","name":"RNA-binding"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000528901.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"12508121","citationType":"journal article","authors":["Heilig R.","Eckenberg R.","Petit J.L.","Fonknechten N.","Da Silva C.","Cattolico L.","Levy M.","Barbe V.","de Berardinis V.","Ureta-Vidal A.","Pelletier E.","Vico V.","Anthouard V.","Rowen L.","Madan A.","Qin S.","Sun H.","Du H.","Pepin K.","Artiguenave F.","Robert C.","Cruaud C.","Bruls T.","Jaillon O.","Friedlander L.","Samson G.","Brottier P.","Cure S.","Segurens B.","Aniere F.","Samain S.","Crespeau H.","Abbasi N.","Aiach N.","Boscus D.","Dickhoff R.","Dors M.","Dubois I.","Friedman C.","Gouyvenoux M.","James R.","Madan A.","Mairey-Estrada B.","Mangenot S.","Martins N.","Menard M.","Oztas S.","Ratcliffe A.","Shaffer T.","Trask B.","Vacherie B.","Bellemere C.","Belser C.","Besnard-Gonnet M.","Bartol-Mavel D.","Boutard M.","Briez-Silla S.","Combette S.","Dufosse-Laurent V.","Ferron C.","Lechaplais C.","Louesse C.","Muselet D.","Magdelenat G.","Pateau E.","Petit E.","Sirvain-Trukniewicz P.","Trybou A.","Vega-Czarny N.","Bataille E.","Bluet E.","Bordelais I.","Dubois M.","Dumont C.","Guerin T.","Haffray S.","Hammadi R.","Muanga J.","Pellouin V.","Robert D.","Wunderle E.","Gauguet G.","Roy A.","Sainte-Marthe L.","Verdier J.","Verdier-Discala C.","Hillier L.","Fulton L.","McPherson J.","Matsuda F.","Wilson R.","Scarpelli C.","Gyapay G.","Wincker P.","Saurin W.","Quetier F.","Waterston R.","Hood L.","Weissenbach J."],"citationCrossReferences":[{"database":"PubMed","id":"12508121"},{"database":"DOI","id":"10.1038/nature01348"}],"title":"The DNA sequence and analysis of human chromosome 14.","publicationDate":"2003","journal":"Nature","firstPage":"601","lastPage":"607","volume":"421"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000528901.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000528901.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000528901.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL139785","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000858842.1","properties":[{"key":"ProteinId","value":"ENSP00000528901.1"},{"key":"GeneId","value":"ENSG00000134001.16"}]},{"database":"HGNC","id":"HGNC:3265","properties":[{"key":"GeneName","value":"EIF2S1"}]},{"database":"OpenTargets","id":"ENSG00000134001","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00390000007015","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 14"}]},{"database":"CDD","id":"cd04452","properties":[{"key":"EntryName","value":"S1_IF2_alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.150.190:FF:000001","properties":[{"key":"EntryName","value":"Eukaryotic translation initiation factor 2 subunit 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.40.50.140:FF:000795","properties":[{"key":"EntryName","value":"Eukaryotic translation initiation factor 2 subunit 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.70.1130:FF:000001","properties":[{"key":"EntryName","value":"Eukaryotic translation initiation factor 2 subunit 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.70.1130","properties":[{"key":"EntryName","value":"EIF_2_alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.40.50.140","properties":[{"key":"EntryName","value":"Nucleic acid-binding proteins"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.150.190","properties":[{"key":"EntryName","value":"Translation initiation factor 2, subunit 1, domain 2"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR012340","properties":[{"key":"EntryName","value":"NA-bd_OB-fold"}]},{"database":"InterPro","id":"IPR003029","properties":[{"key":"EntryName","value":"S1_domain"}]},{"database":"InterPro","id":"IPR044126","properties":[{"key":"EntryName","value":"S1_IF2_alpha"}]},{"database":"InterPro","id":"IPR024055","properties":[{"key":"EntryName","value":"TIF2_asu_C"}]},{"database":"InterPro","id":"IPR024054","properties":[{"key":"EntryName","value":"TIF2_asu_middle_sf"}]},{"database":"InterPro","id":"IPR011488","properties":[{"key":"EntryName","value":"TIF_2_asu"}]},{"database":"PANTHER","id":"PTHR10602","properties":[{"key":"EntryName","value":"EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10602:SF0","properties":[{"key":"EntryName","value":"EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07541","properties":[{"key":"EntryName","value":"EIF_2_alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00575","properties":[{"key":"EntryName","value":"S1"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00316","properties":[{"key":"EntryName","value":"S1"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF110993","properties":[{"key":"EntryName","value":"eIF-2-alpha, C-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF116742","properties":[{"key":"EntryName","value":"eIF2alpha middle domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF50249","properties":[{"key":"EntryName","value":"Nucleic acid-binding proteins"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50126","properties":[{"key":"EntryName","value":"S1"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MPGLSCRFYQHKFPEVEDVVMVNVRSIAEMGAYVSLLEYNNIEGMILLSELSRRRIRSINKLIRIGRNECVVVIRVDKEKGYIDLSKRRVSPEEAIKCEDKFTKSKTVYSILRHVAEVLEYTKDEQLESLFQRTAWVFDDKYKRPGYGAYDAFKHAVSLDLNEDEREVLINNINRRLTPQAVKIRADIEVACYGYEGIDAVKEALRAGLNCSTENMPIKINLIAPPRYVMTTTTLERTEGLSVLSQAMAVIKEKIEEKRGVFNVQMEPKVVTDTDETELARQMERLERENAEVDGDDDAEEMEAKAED","length":308,"molWeight":35384,"crc64":"79EF358D52831501","md5":"1D47BD4ED39DA69B5159A57DD8B967E0"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Domain":1,"Region":1,"Compositional bias":1},"uniParcId":"UPI00403221E9"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"G3V4T5","uniProtkbId":"G3V4T5_HUMAN","entryAudit":{"firstPublicDate":"2011-11-16","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-11-16","entryVersion":94,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000451975.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00020950"}],"value":"Eukaryotic translation initiation factor 2 subunit 1"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00033370"}],"value":"Eukaryotic translation initiation factor 2 subunit alpha"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000451975.1"}],"value":"EIF2S1"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004210"}],"value":"Cytoplasm, Stress granule","id":"SL-0496"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007223"}],"value":"Belongs to the eIF-2-alpha family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":17,"modifier":"EXACT"},"end":{"value":88,"modifier":"EXACT"}},"description":"S1 motif","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50126"}]},{"type":"Non-terminal residue","location":{"start":{"value":273,"modifier":"EXACT"},"end":{"value":273,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000451975.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022540"}],"id":"KW-0396","category":"Molecular function","name":"Initiation factor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022917"}],"id":"KW-0648","category":"Biological process","name":"Protein biosynthesis"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"G3V4T5"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"G3V4T5"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000451975.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"12508121","citationType":"journal article","authors":["Heilig R.","Eckenberg R.","Petit J.L.","Fonknechten N.","Da Silva C.","Cattolico L.","Levy M.","Barbe V.","de Berardinis V.","Ureta-Vidal A.","Pelletier E.","Vico V.","Anthouard V.","Rowen L.","Madan A.","Qin S.","Sun H.","Du H.","Pepin K.","Artiguenave F.","Robert C.","Cruaud C.","Bruls T.","Jaillon O.","Friedlander L.","Samson G.","Brottier P.","Cure S.","Segurens B.","Aniere F.","Samain S.","Crespeau H.","Abbasi N.","Aiach N.","Boscus D.","Dickhoff R.","Dors M.","Dubois I.","Friedman C.","Gouyvenoux M.","James R.","Madan A.","Mairey-Estrada B.","Mangenot S.","Martins N.","Menard M.","Oztas S.","Ratcliffe A.","Shaffer T.","Trask B.","Vacherie B.","Bellemere C.","Belser C.","Besnard-Gonnet M.","Bartol-Mavel D.","Boutard M.","Briez-Silla S.","Combette S.","Dufosse-Laurent V.","Ferron C.","Lechaplais C.","Louesse C.","Muselet D.","Magdelenat G.","Pateau E.","Petit E.","Sirvain-Trukniewicz P.","Trybou A.","Vega-Czarny N.","Bataille E.","Bluet E.","Bordelais I.","Dubois M.","Dumont C.","Guerin T.","Haffray S.","Hammadi R.","Muanga J.","Pellouin V.","Robert D.","Wunderle E.","Gauguet G.","Roy A.","Sainte-Marthe L.","Verdier J.","Verdier-Discala C.","Hillier L.","Fulton L.","McPherson J.","Matsuda F.","Wilson R.","Scarpelli C.","Gyapay G.","Wincker P.","Saurin W.","Quetier F.","Waterston R.","Hood L.","Weissenbach J."],"citationCrossReferences":[{"database":"PubMed","id":"12508121"},{"database":"DOI","id":"10.1038/nature01348"}],"title":"The DNA sequence and analysis of human chromosome 14.","publicationDate":"2003","journal":"Nature","firstPage":"601","lastPage":"607","volume":"421"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000451975.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000451975.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"19690332","citationType":"journal article","authors":["Mayya V.","Lundgren D.H.","Hwang S.I.","Rezaul K.","Wu L.","Eng J.K.","Rodionov V.","Han D.K."],"citationCrossReferences":[{"database":"PubMed","id":"19690332"},{"database":"DOI","id":"10.1126/scisignal.2000007"}],"title":"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.","publicationDate":"2009","journal":"Sci. Signal.","firstPage":"RA46","lastPage":"RA46","volume":"2"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"19690332"}]},{"referenceNumber":5,"citation":{"id":"19608861","citationType":"journal article","authors":["Choudhary C.","Kumar C.","Gnad F.","Nielsen M.L.","Rehman M.","Walther T.C.","Olsen J.V.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"19608861"},{"database":"DOI","id":"10.1126/science.1175371"}],"title":"Lysine acetylation targets protein complexes and co-regulates major cellular functions.","publicationDate":"2009","journal":"Science","firstPage":"834","lastPage":"840","volume":"325"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"19608861"}]},{"referenceNumber":6,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Burckstummer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"21269460"}]},{"referenceNumber":7,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"23186163"}]},{"referenceNumber":8,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"24275569"}]},{"referenceNumber":9,"citation":{"id":"25944712","citationType":"journal article","authors":["Vaca Jacome A.S.","Rabilloud T.","Schaeffer-Reiss C.","Rompais M.","Ayoub D.","Lane L.","Bairoch A.","Van Dorsselaer A.","Carapito C."],"citationCrossReferences":[{"database":"PubMed","id":"25944712"}],"title":"N-terminome analysis of the human mitochondrial proteome.","publicationDate":"2015","journal":"Proteomics","firstPage":"2519","lastPage":"2524","volume":"15"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"25944712"}]},{"referenceNumber":10,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000451975.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL139785","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"G3V4T5","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"G3V4T5","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"G3V4T5","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"33324","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"3181","properties":[{"key":"antibodies","value":"953 antibodies from 42 providers"}]},{"database":"Ensembl","id":"ENST00000557310.5","properties":[{"key":"ProteinId","value":"ENSP00000451975.1"},{"key":"GeneId","value":"ENSG00000134001.16"}]},{"database":"UCSC","id":"uc059cpc.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:3265","properties":[{"key":"GeneName","value":"EIF2S1"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000134001","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00390000007015","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_033458_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"DVNEHQR","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"1685042at2759","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 14"}]},{"database":"Bgee","id":"ENSG00000134001","properties":[{"key":"ExpressionPatterns","value":"Expressed in islet of Langerhans and 214 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"G3V4T5","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0010494","properties":[{"key":"GoTerm","value":"C:cytoplasmic stress granule"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0003723","properties":[{"key":"GoTerm","value":"F:RNA binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0003743","properties":[{"key":"GoTerm","value":"F:translation initiation factor activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0034976","properties":[{"key":"GoTerm","value":"P:response to endoplasmic reticulum stress"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd04452","properties":[{"key":"EntryName","value":"S1_IF2_alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.150.190:FF:000001","properties":[{"key":"EntryName","value":"Eukaryotic translation initiation factor 2 subunit 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.40.50.140:FF:000795","properties":[{"key":"EntryName","value":"Eukaryotic translation initiation factor 2 subunit 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.70.1130","properties":[{"key":"EntryName","value":"EIF_2_alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.40.50.140","properties":[{"key":"EntryName","value":"Nucleic acid-binding proteins"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.150.190","properties":[{"key":"EntryName","value":"Translation initiation factor 2, subunit 1, domain 2"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR012340","properties":[{"key":"EntryName","value":"NA-bd_OB-fold"}]},{"database":"InterPro","id":"IPR003029","properties":[{"key":"EntryName","value":"S1_domain"}]},{"database":"InterPro","id":"IPR044126","properties":[{"key":"EntryName","value":"S1_IF2_alpha"}]},{"database":"InterPro","id":"IPR024055","properties":[{"key":"EntryName","value":"TIF2_asu_C"}]},{"database":"InterPro","id":"IPR024054","properties":[{"key":"EntryName","value":"TIF2_asu_middle_sf"}]},{"database":"InterPro","id":"IPR011488","properties":[{"key":"EntryName","value":"TIF_2_asu"}]},{"database":"PANTHER","id":"PTHR10602","properties":[{"key":"EntryName","value":"EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10602:SF0","properties":[{"key":"EntryName","value":"EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07541","properties":[{"key":"EntryName","value":"EIF_2_alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00575","properties":[{"key":"EntryName","value":"S1"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00316","properties":[{"key":"EntryName","value":"S1"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF110993","properties":[{"key":"EntryName","value":"eIF-2-alpha, C-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF116742","properties":[{"key":"EntryName","value":"eIF2alpha middle domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF50249","properties":[{"key":"EntryName","value":"Nucleic acid-binding proteins"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50126","properties":[{"key":"EntryName","value":"S1"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MPGLSCRFYQHKFPEVEDVVMVNVRSIAEMGAYVSLLEYNNIEGMILLSELSRRRIRSINKLIRIGRNECVVVIRVDKEKGYIDLSKRRVSPEEAIKCEDKFTKSKTVYSILRHVAEVLEYTKDEQLESLFQRTAWVFDDKYKRPGYGAYDAFKHAVSDPSILDSLDLNEDEREVLINNINRRLTPQAVKIRADIEVACYGYEGIDAVKEALRAGLNCSTENMPIKINLIAPPRYVMTTTTLERTEGLSVLSQAMAVIKEKIEEKRGVFNVQM","length":273,"molWeight":31320,"crc64":"DF07C41602C60D08","md5":"802394C0BA4B2DBA678354458062769D"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Domain":1,"Non-terminal residue":1},"uniParcId":"UPI00021CF2C3"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8UL10","uniProtkbId":"A0ACI8UL10_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000620642.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00020950"}],"value":"Eukaryotic translation initiation factor 2 subunit 1"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00033370"}],"value":"Eukaryotic translation initiation factor 2 subunit alpha"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000620642.1"}],"value":"EIF2S1"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004210"}],"value":"Cytoplasm, Stress granule","id":"SL-0496"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004514"}],"value":"Cytoplasm, cytosol","id":"SL-0091"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007223"}],"value":"Belongs to the eIF-2-alpha family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":17,"modifier":"EXACT"},"end":{"value":88,"modifier":"EXACT"}},"description":"S1 motif","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50126"}]},{"type":"Region","location":{"start":{"value":269,"modifier":"EXACT"},"end":{"value":291,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":275,"modifier":"EXACT"},"end":{"value":284,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022540"}],"id":"KW-0396","category":"Molecular function","name":"Initiation factor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022917"}],"id":"KW-0648","category":"Biological process","name":"Protein biosynthesis"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8UL10"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8UL10"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022884"}],"id":"KW-0694","category":"Molecular function","name":"RNA-binding"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000620642.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"12508121","citationType":"journal article","authors":["Heilig R.","Eckenberg R.","Petit J.L.","Fonknechten N.","Da Silva C.","Cattolico L.","Levy M.","Barbe V.","de Berardinis V.","Ureta-Vidal A.","Pelletier E.","Vico V.","Anthouard V.","Rowen L.","Madan A.","Qin S.","Sun H.","Du H.","Pepin K.","Artiguenave F.","Robert C.","Cruaud C.","Bruls T.","Jaillon O.","Friedlander L.","Samson G.","Brottier P.","Cure S.","Segurens B.","Aniere F.","Samain S.","Crespeau H.","Abbasi N.","Aiach N.","Boscus D.","Dickhoff R.","Dors M.","Dubois I.","Friedman C.","Gouyvenoux M.","James R.","Madan A.","Mairey-Estrada B.","Mangenot S.","Martins N.","Menard M.","Oztas S.","Ratcliffe A.","Shaffer T.","Trask B.","Vacherie B.","Bellemere C.","Belser C.","Besnard-Gonnet M.","Bartol-Mavel D.","Boutard M.","Briez-Silla S.","Combette S.","Dufosse-Laurent V.","Ferron C.","Lechaplais C.","Louesse C.","Muselet D.","Magdelenat G.","Pateau E.","Petit E.","Sirvain-Trukniewicz P.","Trybou A.","Vega-Czarny N.","Bataille E.","Bluet E.","Bordelais I.","Dubois M.","Dumont C.","Guerin T.","Haffray S.","Hammadi R.","Muanga J.","Pellouin V.","Robert D.","Wunderle E.","Gauguet G.","Roy A.","Sainte-Marthe L.","Verdier J.","Verdier-Discala C.","Hillier L.","Fulton L.","McPherson J.","Matsuda F.","Wilson R.","Scarpelli C.","Gyapay G.","Wincker P.","Saurin W.","Quetier F.","Waterston R.","Hood L.","Weissenbach J."],"citationCrossReferences":[{"database":"PubMed","id":"12508121"},{"database":"DOI","id":"10.1038/nature01348"}],"title":"The DNA sequence and analysis of human chromosome 14.","publicationDate":"2003","journal":"Nature","firstPage":"601","lastPage":"607","volume":"421"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000620642.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000620642.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000620642.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL139785","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000950583.1","properties":[{"key":"ProteinId","value":"ENSP00000620642.1"},{"key":"GeneId","value":"ENSG00000134001.16"}]},{"database":"HGNC","id":"HGNC:3265","properties":[{"key":"GeneName","value":"EIF2S1"}]},{"database":"OpenTargets","id":"ENSG00000134001","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00390000007015","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 14"}]},{"database":"CDD","id":"cd04452","properties":[{"key":"EntryName","value":"S1_IF2_alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.150.190:FF:000001","properties":[{"key":"EntryName","value":"Eukaryotic translation initiation factor 2 subunit 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.40.50.140:FF:000795","properties":[{"key":"EntryName","value":"Eukaryotic translation initiation factor 2 subunit 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.70.1130:FF:000001","properties":[{"key":"EntryName","value":"Eukaryotic translation initiation factor 2 subunit 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.70.1130","properties":[{"key":"EntryName","value":"EIF_2_alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.40.50.140","properties":[{"key":"EntryName","value":"Nucleic acid-binding proteins"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.150.190","properties":[{"key":"EntryName","value":"Translation initiation factor 2, subunit 1, domain 2"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR012340","properties":[{"key":"EntryName","value":"NA-bd_OB-fold"}]},{"database":"InterPro","id":"IPR003029","properties":[{"key":"EntryName","value":"S1_domain"}]},{"database":"InterPro","id":"IPR044126","properties":[{"key":"EntryName","value":"S1_IF2_alpha"}]},{"database":"InterPro","id":"IPR024055","properties":[{"key":"EntryName","value":"TIF2_asu_C"}]},{"database":"InterPro","id":"IPR024054","properties":[{"key":"EntryName","value":"TIF2_asu_middle_sf"}]},{"database":"InterPro","id":"IPR011488","properties":[{"key":"EntryName","value":"TIF_2_asu"}]},{"database":"PANTHER","id":"PTHR10602","properties":[{"key":"EntryName","value":"EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10602:SF0","properties":[{"key":"EntryName","value":"EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07541","properties":[{"key":"EntryName","value":"EIF_2_alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00575","properties":[{"key":"EntryName","value":"S1"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00316","properties":[{"key":"EntryName","value":"S1"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF110993","properties":[{"key":"EntryName","value":"eIF-2-alpha, C-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF116742","properties":[{"key":"EntryName","value":"eIF2alpha middle domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF50249","properties":[{"key":"EntryName","value":"Nucleic acid-binding proteins"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50126","properties":[{"key":"EntryName","value":"S1"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MPGLSCRFYQHKFPEVEDVVMVNVRSIAEMGAYVSLLEYNNIEGMILLSELSRRRIRSINKLIRIGRNECVVVIRVDKEKGYIDLSKRRVSPEEAIKCEDKFTKSKTVYSILRHVAEVLEYTKDEQLESLFQRTAWVFDDKYKRPGYGAYDAFKHAVSRLTPQAVKIRADIEVACYGYEGIDAVKEALRAGLNCSTENMPIKINLIAPPRYVMTTTTLERTEGLSVLSQAMAVIKEKIEEKRGVFNVQMEPKVVTDTDETELARQMERLERENAEVDGDDDAEEMEAKAED","length":291,"molWeight":33333,"crc64":"D6B6828F2AEB0EA4","md5":"B145C494658D78FA7717C1AF5701B670"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Domain":1,"Region":1,"Compositional bias":1},"uniParcId":"UPI0040319297"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"H0YJS4","uniProtkbId":"H0YJS4_HUMAN","entryAudit":{"firstPublicDate":"2012-02-22","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2012-02-22","entryVersion":80,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000452034.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00020950"}],"value":"Eukaryotic translation initiation factor 2 subunit 1"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00033370"}],"value":"Eukaryotic translation initiation factor 2 subunit alpha"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000452034.1"}],"value":"EIF2S1"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004210"}],"value":"Cytoplasm, Stress granule","id":"SL-0496"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007223"}],"value":"Belongs to the eIF-2-alpha family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":45,"modifier":"EXACT"}},"description":"S1 motif","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50126"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000452034.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022540"}],"id":"KW-0396","category":"Molecular function","name":"Initiation factor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022917"}],"id":"KW-0648","category":"Biological process","name":"Protein biosynthesis"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"H0YJS4"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"H0YJS4"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000452034.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"12508121","citationType":"journal article","authors":["Heilig R.","Eckenberg R.","Petit J.L.","Fonknechten N.","Da Silva C.","Cattolico L.","Levy M.","Barbe V.","de Berardinis V.","Ureta-Vidal A.","Pelletier E.","Vico V.","Anthouard V.","Rowen L.","Madan A.","Qin S.","Sun H.","Du H.","Pepin K.","Artiguenave F.","Robert C.","Cruaud C.","Bruls T.","Jaillon O.","Friedlander L.","Samson G.","Brottier P.","Cure S.","Segurens B.","Aniere F.","Samain S.","Crespeau H.","Abbasi N.","Aiach N.","Boscus D.","Dickhoff R.","Dors M.","Dubois I.","Friedman C.","Gouyvenoux M.","James R.","Madan A.","Mairey-Estrada B.","Mangenot S.","Martins N.","Menard M.","Oztas S.","Ratcliffe A.","Shaffer T.","Trask B.","Vacherie B.","Bellemere C.","Belser C.","Besnard-Gonnet M.","Bartol-Mavel D.","Boutard M.","Briez-Silla S.","Combette S.","Dufosse-Laurent V.","Ferron C.","Lechaplais C.","Louesse C.","Muselet D.","Magdelenat G.","Pateau E.","Petit E.","Sirvain-Trukniewicz P.","Trybou A.","Vega-Czarny N.","Bataille E.","Bluet E.","Bordelais I.","Dubois M.","Dumont C.","Guerin T.","Haffray S.","Hammadi R.","Muanga J.","Pellouin V.","Robert D.","Wunderle E.","Gauguet G.","Roy A.","Sainte-Marthe L.","Verdier J.","Verdier-Discala C.","Hillier L.","Fulton L.","McPherson J.","Matsuda F.","Wilson R.","Scarpelli C.","Gyapay G.","Wincker P.","Saurin W.","Quetier F.","Waterston R.","Hood L.","Weissenbach J."],"citationCrossReferences":[{"database":"PubMed","id":"12508121"},{"database":"DOI","id":"10.1038/nature01348"}],"title":"The DNA sequence and analysis of human chromosome 14.","publicationDate":"2003","journal":"Nature","firstPage":"601","lastPage":"607","volume":"421"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000452034.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000452034.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"19608861","citationType":"journal article","authors":["Choudhary C.","Kumar C.","Gnad F.","Nielsen M.L.","Rehman M.","Walther T.C.","Olsen J.V.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"19608861"},{"database":"DOI","id":"10.1126/science.1175371"}],"title":"Lysine acetylation targets protein complexes and co-regulates major cellular functions.","publicationDate":"2009","journal":"Science","firstPage":"834","lastPage":"840","volume":"325"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"19608861"}]},{"referenceNumber":5,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Burckstummer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"21269460"}]},{"referenceNumber":6,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"23186163"}]},{"referenceNumber":7,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"24275569"}]},{"referenceNumber":8,"citation":{"id":"25944712","citationType":"journal article","authors":["Vaca Jacome A.S.","Rabilloud T.","Schaeffer-Reiss C.","Rompais M.","Ayoub D.","Lane L.","Bairoch A.","Van Dorsselaer A.","Carapito C."],"citationCrossReferences":[{"database":"PubMed","id":"25944712"}],"title":"N-terminome analysis of the human mitochondrial proteome.","publicationDate":"2015","journal":"Proteomics","firstPage":"2519","lastPage":"2524","volume":"15"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"25944712"}]},{"referenceNumber":9,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000452034.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL139785","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"MassIVE","id":"H0YJS4","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"39431","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"3181","properties":[{"key":"antibodies","value":"953 antibodies from 42 providers"}]},{"database":"Ensembl","id":"ENST00000555876.1","properties":[{"key":"ProteinId","value":"ENSP00000452034.1"},{"key":"GeneId","value":"ENSG00000134001.16"}]},{"database":"UCSC","id":"uc059cpe.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:3265","properties":[{"key":"GeneName","value":"EIF2S1"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000134001","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00390000007015","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"1685042at2759","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 14"}]},{"database":"Bgee","id":"ENSG00000134001","properties":[{"key":"ExpressionPatterns","value":"Expressed in islet of Langerhans and 214 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"H0YJS4","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0010494","properties":[{"key":"GoTerm","value":"C:cytoplasmic stress granule"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0003723","properties":[{"key":"GoTerm","value":"F:RNA binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0003743","properties":[{"key":"GoTerm","value":"F:translation initiation factor activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"FunFam","id":"1.10.150.190:FF:000001","properties":[{"key":"EntryName","value":"Eukaryotic translation initiation factor 2 subunit 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.70.1130","properties":[{"key":"EntryName","value":"EIF_2_alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.40.50.140","properties":[{"key":"EntryName","value":"Nucleic acid-binding proteins"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.150.190","properties":[{"key":"EntryName","value":"Translation initiation factor 2, subunit 1, domain 2"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR012340","properties":[{"key":"EntryName","value":"NA-bd_OB-fold"}]},{"database":"InterPro","id":"IPR003029","properties":[{"key":"EntryName","value":"S1_domain"}]},{"database":"InterPro","id":"IPR024055","properties":[{"key":"EntryName","value":"TIF2_asu_C"}]},{"database":"InterPro","id":"IPR024054","properties":[{"key":"EntryName","value":"TIF2_asu_middle_sf"}]},{"database":"InterPro","id":"IPR011488","properties":[{"key":"EntryName","value":"TIF_2_asu"}]},{"database":"PANTHER","id":"PTHR10602","properties":[{"key":"EntryName","value":"EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10602:SF0","properties":[{"key":"EntryName","value":"EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07541","properties":[{"key":"EntryName","value":"EIF_2_alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00575","properties":[{"key":"EntryName","value":"S1"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF110993","properties":[{"key":"EntryName","value":"eIF-2-alpha, C-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF116742","properties":[{"key":"EntryName","value":"eIF2alpha middle domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF50249","properties":[{"key":"EntryName","value":"Nucleic acid-binding proteins"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50126","properties":[{"key":"EntryName","value":"S1"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"XMILLSELSRRRIRSINKLIRIGRNECVVVIRVDKEKGYIDLSKRRVSPEEAIKCEDKFTKSKTVYSILRHVAEVLEYTKDEQLESLFQRTAWVFDDKYKRPGYGAYDAFKHAVSDPSILDSLDLNEDEREVLINNINRRLTPQAVKIRADIEVACYGYEGIDAVKEALRAGLNCSTENMPIKINLIAPPRYVMTTTTLERTEGLSVLSQAMAVIKEKIEEKRGVFNVQMEVRSIDSFLIMTQEVPKRSSCR","length":252,"molWeight":28977,"crc64":"68A208399C45F2CE","md5":"9956B962D5A3AE9E396B91B4992355AD"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Domain":1,"Non-terminal residue":1},"uniParcId":"UPI00021CF2C4"}}]}