{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q03001","secondaryAccessions":["B7Z3H1","E7ERU0","O94833","Q12825","Q13266","Q13267","Q13775","Q5TBT0","Q5TBT2","Q5TF23","Q5TF24","Q8N1T8","Q8N8J3","Q8WXK8","Q8WXK9","Q96AK9","Q96DQ5","Q96J76","Q96QT5","Q9H555","Q9UGD7","Q9UGD8","Q9UN10"],"uniProtkbId":"DYST_HUMAN","entryAudit":{"firstPublicDate":"1996-10-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2010-04-20","entryVersion":249,"sequenceVersion":4},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Dystonin"}},"alternativeNames":[{"fullName":{"value":"230 kDa bullous pemphigoid antigen"}},{"fullName":{"value":"230/240 kDa bullous pemphigoid antigen"}},{"fullName":{"value":"Bullous pemphigoid antigen 1"},"shortNames":[{"value":"BPA"},{"value":"Bullous pemphigoid antigen"}]},{"fullName":{"value":"Dystonia musculorum protein"}},{"fullName":{"value":"Hemidesmosomal plaque protein"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:1090"}],"value":"DST"},"synonyms":[{"value":"BP230"},{"value":"BP240"},{"value":"BPAG1"},{"value":"DMH"},{"value":"DT"},{"value":"KIAA0728"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q91ZU6"}],"value":"Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Mediates docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport through its interaction with TMEM108 and DCTN1 (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"value":"Plays a structural role in the assembly of hemidesmosomes of epithelial cells; anchors keratin-containing intermediate filaments to the inner plaque of hemidesmosomes. Required for the regulation of keratinocyte polarity and motility; mediates integrin ITGB4 regulation of RAC1 activity"}],"commentType":"FUNCTION","molecule":"Isoform 3"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10428034"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12482924"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19403692"}],"value":"Required for bundling actin filaments around the nucleus"}],"commentType":"FUNCTION","molecule":"Isoform 6"},{"texts":[{"value":"Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport"}],"commentType":"FUNCTION","molecule":"Isoform 7"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q91ZU6"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10637308"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11375975"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12482924"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19632184"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19932097"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22419821"}],"value":"Homodimer. Isoform 1 interacts (via N-terminus) with PLEC (via N-terminus). Interacts with the neuronal intermediate filament protein, PRPH. Interacts with DES. Interacts with SYNE3 (By similarity). Isoform 1 and isoform 6 can homodimerize (via N-terminus). Isoform 1 interacts (via N-terminus) with ACTN2. Isoform 1 interacts (via N-terminus) with PLEC (via N-terminus). Isoform 3 interacts (via N-terminus) with COL17A1 (via cytoplasmic region). Isoform 3 interacts (via N-terminus) with ITGB4 isoform beta-4a (via cytoplasmic region). Isoform 3 interacts (via N-terminus) with ERBIN (via C-terminus). Isoform 3 associates (via C-terminal) with KRT5-KRT14 (via rod region) intermediate filaments of keratins. Interacts with MAPRE1; probably required for targeting to the growing microtubule plus ends. Interacts with TMIGD2. Isoform 9 interacts with TMEM108 (By similarity)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q03001","intActId":"EBI-310758"},"interactantTwo":{"uniProtKBAccession":"Q9UKG1","geneName":"APPL1","intActId":"EBI-741243"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q03001","intActId":"EBI-310758"},"interactantTwo":{"uniProtKBAccession":"Q9NRI5","geneName":"DISC1","intActId":"EBI-529989"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q03001","intActId":"EBI-310758"},"interactantTwo":{"uniProtKBAccession":"Q15691","geneName":"MAPRE1","intActId":"EBI-1004115"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q03001","intActId":"EBI-310758"},"interactantTwo":{"uniProtKBAccession":"Q61166","geneName":"Mapre1","intActId":"EBI-2027055"},"numberOfExperiments":4,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"Q03001","intActId":"EBI-310758"},"interactantTwo":{"uniProtKBAccession":"P29991","chainId":"PRO_0000037946","intActId":"EBI-8826488"},"numberOfExperiments":4,"organismDiffer":true}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q91ZU6"}],"value":"Associates with intermediate filaments, actin and microtubule cytoskeletons. Localizes to actin stress fibers and to actin-rich ruffling at the cortex of cells (By similarity). Associated at the growing distal tip of microtubules"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11751855"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19932097"}],"value":"Cytoplasm, cytoskeleton","id":"SL-0090"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q91ZU6"}],"value":"Cytoplasm, cytoskeleton, stress fiber","id":"SL-0501"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q91ZU6"}],"value":"Cell projection, axon","id":"SL-0279"}}]},{"commentType":"SUBCELLULAR LOCATION","molecule":"Isoform 1","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Localizes to microtubules and actin microfilaments throughout the cytoplasm and at focal contact attachments at the plasma membrane"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Cytoplasm, cytoskeleton","id":"SL-0090"}},{"location":{"value":"Cytoplasm, myofibril, sarcomere, Z line","id":"SL-0314"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Cytoplasm, myofibril, sarcomere, H zone","id":"SL-0477"}}]},{"commentType":"SUBCELLULAR LOCATION","molecule":"Isoform 2","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Colocalizes both cortical and cytoplasmic actin filaments"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Cytoplasm, cytoskeleton","id":"SL-0090"}}]},{"commentType":"SUBCELLULAR LOCATION","molecule":"Isoform 3","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Localizes to actin and intermediate filaments cytoskeletons (By similarity). Colocalizes with the epidermal KRT5-KRT14 intermediate filaments network of keratins. Colocalizes with ITGB4 at the leading edge of migrating keratinocytes"}]},"subcellularLocations":[{"location":{"value":"Cytoplasm, cytoskeleton","id":"SL-0090"}},{"location":{"value":"Cell junction, hemidesmosome","id":"SL-0137"}}]},{"commentType":"SUBCELLULAR LOCATION","molecule":"Isoform 6","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q91ZU6"}],"value":"Localizes to actin and intermediate filaments cytoskeletons. Localizes to central actin stress fibers around the nucleus and is excluded form focal contact sites in myoblast cells. Translocates to the nucleus (By similarity). Associates with actin cytoskeleton in sensory neurons"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q91ZU6"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10428034"}],"value":"Nucleus envelope","id":"SL-0178"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10428034"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10428034"}],"value":"Single-pass membrane protein","id":"SL-9904"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q91ZU6"}],"value":"Endoplasmic reticulum membrane","id":"SL-0097"},"topology":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q91ZU6"}],"value":"Single-pass membrane protein","id":"SL-9904"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10428034"}],"value":"Cytoplasm, cytoskeleton","id":"SL-0090"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q91ZU6"}],"value":"Cytoplasm, cytoskeleton, stress fiber","id":"SL-0501"}}]},{"commentType":"SUBCELLULAR LOCATION","molecule":"Isoform 7","note":{"texts":[{"value":"Associates with axonal microtubules and intermediate filaments, but not with actin cytoskeleton, in sensory neurons"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10428034"}],"value":"Cytoplasm, cytoskeleton","id":"SL-0090"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10428034"}],"value":"Cell projection, axon","id":"SL-0279"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10428034"}],"value":"Membrane","id":"SL-0162"}}]},{"commentType":"SUBCELLULAR LOCATION","molecule":"Isoform 8","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Cytoplasm, cytoskeleton","id":"SL-0090"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Cytoplasm, cell cortex","id":"SL-0138"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Lipid-anchor","id":"SL-9901"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative promoter usage","Alternative splicing"],"isoforms":[{"name":{"value":"1"},"synonyms":[{"value":"BPAG1-b"}],"isoformIds":["Q03001-7"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"synonyms":[{"value":"BPAG1eA"},{"value":"Dystonin-1"},{"value":"eA"}],"isoformIds":["Q03001-8"],"sequenceIds":["VSP_041525","VSP_041535","VSP_041539","VSP_041540"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"synonyms":[{"value":"BPAG1e"},{"value":"eBPAG1"}],"isoformIds":["Q03001-3"],"sequenceIds":["VSP_041525","VSP_041533","VSP_041534"],"isoformSequenceStatus":"Described"},{"name":{"value":"4"},"synonyms":[{"value":"BPAG1eA"},{"value":"eB"}],"isoformIds":["Q03001-9"],"sequenceIds":["VSP_041525","VSP_041536"],"isoformSequenceStatus":"Described"},{"name":{"value":"5"},"isoformIds":["Q03001-10"],"sequenceIds":["VSP_041524","VSP_041537","VSP_041538"],"isoformSequenceStatus":"Described"},{"name":{"value":"6"},"synonyms":[{"value":"BPAG1n1"},{"value":"BPAG1n2"},{"value":"Dystonin-2"}],"isoformIds":["Q03001-11"],"sequenceIds":["VSP_041528","VSP_041529"],"isoformSequenceStatus":"Described"},{"name":{"value":"7"},"synonyms":[{"value":"BPAG1n3"}],"isoformIds":["Q03001-12"],"sequenceIds":["VSP_041526","VSP_041530"],"isoformSequenceStatus":"Described"},{"name":{"value":"8"},"isoformIds":["Q03001-13"],"sequenceIds":["VSP_041527","VSP_041531","VSP_041532"],"isoformSequenceStatus":"Described"},{"name":{"value":"9"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14581450"}],"value":"BPAG1-a"},{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14581450"}],"value":"BAPG1n4"}],"isoformIds":["Q03001-14"],"sequenceIds":["VSP_058835","VSP_058836"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11751855"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19932097"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8752219"}],"value":"Isoform 1 is expressed in myoblasts (at protein level). Isoform 3 is expressed in the skin. Isoform 6 is expressed in the brain. Highly expressed in skeletal muscle and cultured keratinocytes"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"value":"Its association with epidermal and simple keratins is dependent on the tertiary structure induced by heterodimerization of these intermediate filaments proteins and most likely involves recognition sites located in the rod domain of these keratins"}],"commentType":"DOMAIN"},{"texts":[{"value":"The microtubule tip localization signal (MtLS) motif; mediates interaction with MAPRE1 and targeting to the growing microtubule plus ends"}],"commentType":"DOMAIN"},{"commentType":"DISEASE","disease":{"diseaseId":"Neuropathy, hereditary sensory and autonomic, 6","diseaseAccession":"DI-03461","acronym":"HSAN6","description":"A form of hereditary sensory and autonomic neuropathy, a genetically and clinically heterogeneous group of disorders characterized by degeneration of dorsal root and autonomic ganglion cells, and by sensory and/or autonomic abnormalities. HSAN6 is a severe autosomal recessive disorder characterized by neonatal hypotonia, respiratory and feeding difficulties, lack of psychomotor development, and autonomic abnormalities including labile cardiovascular function, lack of corneal reflexes leading to corneal scarring, areflexia, and absent axonal flare response after intradermal histamine injection.","diseaseCrossReference":{"database":"MIM","id":"614653"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28767192"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"Epidermolysis bullosa simplex 3, localized or generalized intermediate, with BP230 deficiency","diseaseAccession":"DI-03906","acronym":"EBS3","description":"A form of epidermolysis bullosa, a genodermatosis characterized by recurrent blistering, fragility of the skin and mucosal epithelia, and erosions caused by minor mechanical trauma. EBS3 is an autosomal recessive disorder characterized by skin blistering mainly occurring on the feet and ankles. Ultrastructural analysis of skin biopsy shows abnormal hemidesmosomes with poorly formed inner plaques.","diseaseCrossReference":{"database":"MIM","id":"615425"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20164846"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22113475"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35276021"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"Congenital myopathy 29 with contractures","diseaseAccession":"DI-07156","acronym":"CMYO29","description":"A form of congenital myopathy, a clinically and genetically heterogeneous group of muscle disorders characterized by hypotonia and muscle weakness typically noticed at birth or during the neonatal period, and specific pathological features on muscle biopsy. CMYO29 is an autosomal recessive form characterized by hypotonia, distal joint contractures, and early respiratory and feeding difficulties. Most patients develop dilated cardiomyopathy, which often leads to death in infancy or early childhood.","diseaseCrossReference":{"database":"MIM","id":"621510"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"40497796"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"Lethal congenital contracture syndrome 12","diseaseAccession":"DI-07157","acronym":"LCCS12","description":"A form of lethal congenital contracture syndrome, an autosomal recessive disorder characterized by degeneration of anterior horn neurons, extreme skeletal muscle atrophy and congenital non-progressive joint contractures. The contractures can involve the upper or lower limbs and/or the vertebral column, leading to various degrees of flexion or extension limitations evident at birth. LCCS12 is a severe form with onset in utero that results in death in utero or during the perinatal period, or in the first years of life.","diseaseCrossReference":{"database":"MIM","id":"621511"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22522446"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35276021"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"40497796"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Incomplete sequence"}],"commentType":"MISCELLANEOUS","molecule":"Isoform 4"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay"}],"commentType":"MISCELLANEOUS","molecule":"Isoform 5"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Incomplete sequence. Transmembrane protein (helical transmembrane domain from amino acid 18 to 38)"}],"commentType":"MISCELLANEOUS","molecule":"Isoform 6"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Incomplete sequence"}],"commentType":"MISCELLANEOUS","molecule":"Isoform 7"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Probably myristoylated on Gly-2. Probably S-palmitoylated on Cys-5 and Cys-7"}],"commentType":"MISCELLANEOUS","molecule":"Isoform 8"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Miscellaneous discrepancy","sequence":"AAA35538.1","note":"Contaminating sequence. Sequence of unknown origin in the C-terminal part.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous gene model prediction","sequence":"AAA57185.1","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"AAH16991.1","note":"Extended N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"BAB70870.1","note":"Truncated N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"BAC04449.1","note":"Truncated N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"BAC04848.1","note":"Truncated N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","molecule":"Isoform 6","sequenceCautionType":"Frameshift","sequence":"AAC50244.1","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":7570,"modifier":"EXACT"}},"description":"Dystonin","featureId":"PRO_0000078138"},{"type":"Domain","location":{"start":{"value":35,"modifier":"EXACT"},"end":{"value":138,"modifier":"EXACT"}},"description":"Calponin-homology (CH) 1","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00044"}]},{"type":"Domain","location":{"start":{"value":151,"modifier":"EXACT"},"end":{"value":255,"modifier":"EXACT"}},"description":"Calponin-homology (CH) 2","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00044"}]},{"type":"Repeat","location":{"start":{"value":602,"modifier":"EXACT"},"end":{"value":699,"modifier":"EXACT"}},"description":"Spectrin 1"},{"type":"Repeat","location":{"start":{"value":701,"modifier":"EXACT"},"end":{"value":802,"modifier":"EXACT"}},"description":"Spectrin 2"},{"type":"Domain","location":{"start":{"value":887,"modifier":"EXACT"},"end":{"value":944,"modifier":"EXACT"}},"description":"SH3","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00192"}]},{"type":"Repeat","location":{"start":{"value":1293,"modifier":"EXACT"},"end":{"value":1422,"modifier":"EXACT"}},"description":"Spectrin 3"},{"type":"Repeat","location":{"start":{"value":1440,"modifier":"EXACT"},"end":{"value":1540,"modifier":"EXACT"}},"description":"Spectrin 4"},{"type":"Repeat","location":{"start":{"value":1584,"modifier":"EXACT"},"end":{"value":1626,"modifier":"EXACT"}},"description":"Plectin 1"},{"type":"Repeat","location":{"start":{"value":1660,"modifier":"EXACT"},"end":{"value":1703,"modifier":"EXACT"}},"description":"Plectin 2"},{"type":"Repeat","location":{"start":{"value":1774,"modifier":"EXACT"},"end":{"value":1817,"modifier":"EXACT"}},"description":"Plectin 3"},{"type":"Repeat","location":{"start":{"value":1818,"modifier":"EXACT"},"end":{"value":1855,"modifier":"EXACT"}},"description":"Plectin 4"},{"type":"Repeat","location":{"start":{"value":1856,"modifier":"EXACT"},"end":{"value":1891,"modifier":"EXACT"}},"description":"Plectin 5"},{"type":"Repeat","location":{"start":{"value":3395,"modifier":"EXACT"},"end":{"value":3501,"modifier":"EXACT"}},"description":"Spectrin 5"},{"type":"Repeat","location":{"start":{"value":3643,"modifier":"EXACT"},"end":{"value":3752,"modifier":"EXACT"}},"description":"Spectrin 6"},{"type":"Repeat","location":{"start":{"value":3926,"modifier":"EXACT"},"end":{"value":4040,"modifier":"EXACT"}},"description":"Spectrin 7"},{"type":"Repeat","location":{"start":{"value":4047,"modifier":"EXACT"},"end":{"value":4153,"modifier":"EXACT"}},"description":"Spectrin 8"},{"type":"Repeat","location":{"start":{"value":4160,"modifier":"EXACT"},"end":{"value":4259,"modifier":"EXACT"}},"description":"Spectrin 9"},{"type":"Repeat","location":{"start":{"value":4269,"modifier":"EXACT"},"end":{"value":4368,"modifier":"EXACT"}},"description":"Spectrin 10"},{"type":"Repeat","location":{"start":{"value":4516,"modifier":"EXACT"},"end":{"value":4621,"modifier":"EXACT"}},"description":"Spectrin 11"},{"type":"Repeat","location":{"start":{"value":4628,"modifier":"EXACT"},"end":{"value":4732,"modifier":"EXACT"}},"description":"Spectrin 12"},{"type":"Repeat","location":{"start":{"value":4742,"modifier":"EXACT"},"end":{"value":4842,"modifier":"EXACT"}},"description":"Spectrin 13"},{"type":"Repeat","location":{"start":{"value":4849,"modifier":"EXACT"},"end":{"value":4951,"modifier":"EXACT"}},"description":"Spectrin 14"},{"type":"Repeat","location":{"start":{"value":4958,"modifier":"EXACT"},"end":{"value":5058,"modifier":"EXACT"}},"description":"Spectrin 15"},{"type":"Repeat","location":{"start":{"value":5068,"modifier":"EXACT"},"end":{"value":5167,"modifier":"EXACT"}},"description":"Spectrin 16"},{"type":"Repeat","location":{"start":{"value":5174,"modifier":"EXACT"},"end":{"value":5277,"modifier":"EXACT"}},"description":"Spectrin 17"},{"type":"Repeat","location":{"start":{"value":5284,"modifier":"EXACT"},"end":{"value":5388,"modifier":"EXACT"}},"description":"Spectrin 18"},{"type":"Repeat","location":{"start":{"value":5395,"modifier":"EXACT"},"end":{"value":5497,"modifier":"EXACT"}},"description":"Spectrin 19"},{"type":"Repeat","location":{"start":{"value":5504,"modifier":"EXACT"},"end":{"value":5715,"modifier":"EXACT"}},"description":"Spectrin 20"},{"type":"Repeat","location":{"start":{"value":5831,"modifier":"EXACT"},"end":{"value":5933,"modifier":"EXACT"}},"description":"Spectrin 21"},{"type":"Repeat","location":{"start":{"value":5941,"modifier":"EXACT"},"end":{"value":6041,"modifier":"EXACT"}},"description":"Spectrin 22"},{"type":"Repeat","location":{"start":{"value":6048,"modifier":"EXACT"},"end":{"value":6154,"modifier":"EXACT"}},"description":"Spectrin 23"},{"type":"Repeat","location":{"start":{"value":6161,"modifier":"EXACT"},"end":{"value":6263,"modifier":"EXACT"}},"description":"Spectrin 24"},{"type":"Repeat","location":{"start":{"value":6270,"modifier":"EXACT"},"end":{"value":6373,"modifier":"EXACT"}},"description":"Spectrin 25"},{"type":"Repeat","location":{"start":{"value":6380,"modifier":"EXACT"},"end":{"value":6482,"modifier":"EXACT"}},"description":"Spectrin 26"},{"type":"Repeat","location":{"start":{"value":6489,"modifier":"EXACT"},"end":{"value":6591,"modifier":"EXACT"}},"description":"Spectrin 27"},{"type":"Repeat","location":{"start":{"value":6598,"modifier":"EXACT"},"end":{"value":6700,"modifier":"EXACT"}},"description":"Spectrin 28"},{"type":"Repeat","location":{"start":{"value":6707,"modifier":"EXACT"},"end":{"value":6810,"modifier":"EXACT"}},"description":"Spectrin 29"},{"type":"Repeat","location":{"start":{"value":6817,"modifier":"EXACT"},"end":{"value":6918,"modifier":"EXACT"}},"description":"Spectrin 30"},{"type":"Repeat","location":{"start":{"value":6925,"modifier":"EXACT"},"end":{"value":7027,"modifier":"EXACT"}},"description":"Spectrin 31"},{"type":"Repeat","location":{"start":{"value":7037,"modifier":"EXACT"},"end":{"value":7167,"modifier":"EXACT"}},"description":"Spectrin 32"},{"type":"Domain","location":{"start":{"value":7197,"modifier":"EXACT"},"end":{"value":7232,"modifier":"EXACT"}},"description":"EF-hand 1","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00448"}]},{"type":"Domain","location":{"start":{"value":7233,"modifier":"EXACT"},"end":{"value":7268,"modifier":"EXACT"}},"description":"EF-hand 2","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00448"}]},{"type":"Domain","location":{"start":{"value":7273,"modifier":"EXACT"},"end":{"value":7351,"modifier":"EXACT"}},"description":"GAR","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00792"}]},{"type":"Region","location":{"start":{"value":35,"modifier":"EXACT"},"end":{"value":252,"modifier":"EXACT"}},"description":"Actin-binding"},{"type":"Region","location":{"start":{"value":2317,"modifier":"EXACT"},"end":{"value":2346,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":2383,"modifier":"EXACT"},"end":{"value":2441,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":2585,"modifier":"EXACT"},"end":{"value":2616,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":3190,"modifier":"EXACT"},"end":{"value":3221,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":7358,"modifier":"EXACT"},"end":{"value":7379,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":7395,"modifier":"EXACT"},"end":{"value":7452,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":7481,"modifier":"EXACT"},"end":{"value":7570,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Motif","location":{"start":{"value":1383,"modifier":"EXACT"},"end":{"value":1389,"modifier":"EXACT"}},"description":"Nuclear localization signal; in isoform 6","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Motif","location":{"start":{"value":7550,"modifier":"EXACT"},"end":{"value":7553,"modifier":"EXACT"}},"description":"Microtubule tip localization signal"},{"type":"Compositional bias","location":{"start":{"value":2336,"modifier":"EXACT"},"end":{"value":2345,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":2385,"modifier":"EXACT"},"end":{"value":2394,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":2395,"modifier":"EXACT"},"end":{"value":2412,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":2430,"modifier":"EXACT"},"end":{"value":2439,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":2591,"modifier":"EXACT"},"end":{"value":2605,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":3192,"modifier":"EXACT"},"end":{"value":3209,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":7362,"modifier":"EXACT"},"end":{"value":7374,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":7411,"modifier":"EXACT"},"end":{"value":7441,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":7490,"modifier":"EXACT"},"end":{"value":7504,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":7519,"modifier":"EXACT"},"end":{"value":7535,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Binding site","location":{"start":{"value":7210,"modifier":"EXACT"},"end":{"value":7210,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00448"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"1"}},{"type":"Binding site","location":{"start":{"value":7212,"modifier":"EXACT"},"end":{"value":7212,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00448"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"1"}},{"type":"Binding site","location":{"start":{"value":7214,"modifier":"EXACT"},"end":{"value":7214,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00448"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"1"}},{"type":"Binding site","location":{"start":{"value":7216,"modifier":"EXACT"},"end":{"value":7216,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00448"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"1"}},{"type":"Binding site","location":{"start":{"value":7221,"modifier":"EXACT"},"end":{"value":7221,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00448"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"1"}},{"type":"Binding site","location":{"start":{"value":7246,"modifier":"EXACT"},"end":{"value":7246,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00448"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"2"}},{"type":"Binding site","location":{"start":{"value":7248,"modifier":"EXACT"},"end":{"value":7248,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00448"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"2"}},{"type":"Binding site","location":{"start":{"value":7250,"modifier":"EXACT"},"end":{"value":7250,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00448"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"2"}},{"type":"Binding site","location":{"start":{"value":7252,"modifier":"EXACT"},"end":{"value":7252,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00448"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"2"}},{"type":"Binding site","location":{"start":{"value":7257,"modifier":"EXACT"},"end":{"value":7257,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00448"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"2"}},{"type":"Modified residue","location":{"start":{"value":236,"modifier":"EXACT"},"end":{"value":236,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q91ZU6"}]},{"type":"Modified residue","location":{"start":{"value":237,"modifier":"EXACT"},"end":{"value":237,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q91ZU6"}]},{"type":"Modified residue","location":{"start":{"value":1382,"modifier":"EXACT"},"end":{"value":1382,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q91ZU6"}]},{"type":"Modified residue","location":{"start":{"value":2229,"modifier":"EXACT"},"end":{"value":2229,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q91ZU6"}]},{"type":"Modified residue","location":{"start":{"value":2919,"modifier":"EXACT"},"end":{"value":2919,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"}]},{"type":"Modified residue","location":{"start":{"value":3968,"modifier":"EXACT"},"end":{"value":3968,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Modified residue","location":{"start":{"value":4749,"modifier":"EXACT"},"end":{"value":4749,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q91ZU6"}]},{"type":"Modified residue","location":{"start":{"value":7432,"modifier":"EXACT"},"end":{"value":7432,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"}]},{"type":"Modified residue","location":{"start":{"value":7510,"modifier":"EXACT"},"end":{"value":7510,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q91ZU6"}]},{"type":"Modified residue","location":{"start":{"value":7513,"modifier":"EXACT"},"end":{"value":7513,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q91ZU6"}]},{"type":"Modified residue","location":{"start":{"value":7525,"modifier":"EXACT"},"end":{"value":7525,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q91ZU6"}]},{"type":"Cross-link","location":{"start":{"value":5470,"modifier":"EXACT"},"end":{"value":5470,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)"},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":3896,"modifier":"EXACT"}},"description":"in isoform 5","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_041524","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":381,"modifier":"EXACT"}},"description":"in isoform 2, isoform 3 and isoform 4","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11751855"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"1712022"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"1717441"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"8345227"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"9872452"}],"featureId":"VSP_041525","alternativeSequence":{"originalSequence":"MAGYLSPAAYLYVEEQEYLQAYEDVLERYKDERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPREKGRMRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGESEDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLANLEHAFYVAEKIGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPEGGEGIGANDVEVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKETEIPPKETEKSKIKRLYKLLEIWIEFGRIKLLQGYHPNDIEKEWGKLIIAMLEREKALRPEVE","alternativeSequences":["MHSSSYSYRSSDSVFSNTTSTRTSLDSNENLLLVHCGPTLINSCISFGSESFDGH"]}},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":138,"modifier":"EXACT"}},"description":"in isoform 7","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"10428034"}],"featureId":"VSP_041526","alternativeSequence":{"originalSequence":"MAGYLSPAAYLYVEEQEYLQAYEDVLERYKDERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPREKGRMRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQ","alternativeSequences":["MQHSIFSLKKKRCHSLYTSMSSVSKDTDGNE"]}},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":138,"modifier":"EXACT"}},"description":"in isoform 8","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"}],"featureId":"VSP_041527","alternativeSequence":{"originalSequence":"MAGYLSPAAYLYVEEQEYLQAYEDVLERYKDERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPREKGRMRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQ","alternativeSequences":["MGNVCGCVRAEKEEQYVDPAKTPLNPEKYSPGRKYFRRKPIKKTGGDKESVGANNENEGKKKSSSQPSKEQPAPLSRGLVQQESVTLNSALGDGIQQKKTEVVADSVKQKLLPSAVSSWSDCVNTSPAKDSETEVKVSELDERISEKDSTPYCAKRKKHLDDVNTSEITFQEKTDVFSFRKAASLSSIPSGIERSLEKGGFPEDPPKSYSSIQEKQNTERFCPHATQHFQFKKKRCHSLYTSMSSVSKDTDGNE"]}},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":30,"modifier":"EXACT"}},"description":"in isoform 6","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"8575775"}],"featureId":"VSP_041528","alternativeSequence":{"originalSequence":"MAGYLSPAAYLYVEEQEYLQAYEDVLERYK","alternativeSequences":["MIAAAFLVLLRPYSIQCALFLLLLLLGTIATIVFFCCWHRKLQKGRHPMKSVFSGRSRSRDAVLRSHHFRSEGFRASPRHLRRRVAAAAAARLEEVKPVVEVHHQSEQETSVRKRRIKKSSRVQPEFYHSVQGASIRRPSSGNASYRCSMSSSADFSDEDDFSQKSGSASPAPGDTLPWNLPKHERSKRKIQGGSVLDPAERAVLRIA"]}},{"type":"Alternative sequence","location":{"start":{"value":47,"modifier":"EXACT"},"end":{"value":7570,"modifier":"EXACT"}},"description":"in isoform 6","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"8575775"}],"featureId":"VSP_041529","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":189,"modifier":"EXACT"},"end":{"value":7570,"modifier":"EXACT"}},"description":"in isoform 7","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"10428034"}],"featureId":"VSP_041530","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":778,"modifier":"EXACT"},"end":{"value":789,"modifier":"EXACT"}},"description":"in isoform 8","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"}],"featureId":"VSP_041531","alternativeSequence":{"originalSequence":"AYRAAMQTQWSW","alternativeSequences":["VKLESVMVLVEY"]}},{"type":"Alternative sequence","location":{"start":{"value":790,"modifier":"EXACT"},"end":{"value":7570,"modifier":"EXACT"}},"description":"in isoform 8","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"}],"featureId":"VSP_041532","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":1433,"modifier":"EXACT"},"end":{"value":1433,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"1712022"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"1717441"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"8345227"}],"featureId":"VSP_041533","alternativeSequence":{"originalSequence":"K","alternativeSequences":["IKRCKETSEHGAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQKSRVEEELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRDEKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNETKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKLMESKVITENDISGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQQYREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIKEHEHQLVLLQCEIQKKSTAKDCTFKPDFEMTVKECQHSGELSSRNTGHLHPTPRSPLLRWTQEPQPLEEKWQHRVVEQIPKEVQFQPPGAPLEKEKSQQCYSEYFSQTSTELQITFDETNPITRLSEIEKIRDQALNNSRPPVRYQDNACEMELVKVLTPLEIAKNKQYDMHTEVTTLKQEKNPVPSAEEWMLEGCRASGGLKKGDFLKKGLEPETFQNFDGDHACSVRDDEFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQKTLNKFLTKATSIAGLYLESTKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKGVVDPEFRIRLLEAEKAAVGYSYSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVIDPVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVESQCFLFPFGERNISNLNVKKTHRISVVDTKTGSELTVYEAFQRNLIEKSIYLELSGQQYQWKEAMFFESYGHSSHMLTDTKTGLHFNINEAIEQGTIDKALVKKYQEGLITLTELADSLLSRLVPKKDLHSPVAGYWLTASGERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEALQVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLLEVSEPLMTGISSLYYSS"]}},{"type":"Alternative sequence","location":{"start":{"value":1434,"modifier":"EXACT"},"end":{"value":7570,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"1712022"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"1717441"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"8345227"}],"featureId":"VSP_041534","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":1550,"modifier":"EXACT"},"end":{"value":3635,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11751855"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"9872452"}],"featureId":"VSP_041535","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":1551,"modifier":"EXACT"},"end":{"value":3636,"modifier":"EXACT"}},"description":"in isoform 9","featureId":"VSP_058835","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":3387,"modifier":"EXACT"},"end":{"value":7570,"modifier":"EXACT"}},"description":"in isoform 4","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11751855"}],"featureId":"VSP_041536","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":4184,"modifier":"EXACT"},"end":{"value":4200,"modifier":"EXACT"}},"description":"in isoform 5","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_041537","alternativeSequence":{"originalSequence":"GQVPLNSTALQDIISKN","alternativeSequences":["DVGTGYCRSSEQYKCHE"]}},{"type":"Alternative sequence","location":{"start":{"value":4201,"modifier":"EXACT"},"end":{"value":7570,"modifier":"EXACT"}},"description":"in isoform 5","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_041538","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":5546,"modifier":"EXACT"},"end":{"value":5654,"modifier":"EXACT"}},"description":"in isoform 9","featureId":"VSP_058836","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":7352,"modifier":"EXACT"},"end":{"value":7375,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11751855"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"9872452"}],"featureId":"VSP_041539","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":7442,"modifier":"EXACT"},"end":{"value":7442,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11751855"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"9872452"}],"featureId":"VSP_041540","alternativeSequence":{"originalSequence":"K","alternativeSequences":["KILHPLTRNYGKPWLTNSKMSTPCKAAECSDFPVPSAE"]}},{"type":"Natural variant","location":{"start":{"value":91,"modifier":"EXACT"},"end":{"value":91,"modifier":"EXACT"}},"description":"in HSAN6; likely pathogenic","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28767192"}],"featureId":"VAR_091644","alternativeSequence":{"originalSequence":"H","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":1091,"modifier":"EXACT"},"end":{"value":7570,"modifier":"EXACT"}},"description":"in LCCS12; likely pathogenic","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35276021"}],"featureId":"VAR_091645","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":1118,"modifier":"EXACT"},"end":{"value":7570,"modifier":"EXACT"}},"description":"in HSAN6 and LCCS12; likely pathogenic","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28767192"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"40497796"}],"featureId":"VAR_091646","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":1319,"modifier":"EXACT"},"end":{"value":1319,"modifier":"EXACT"}},"description":"in dbSNP:rs35014998","featureCrossReferences":[{"database":"dbSNP","id":"rs35014998"}],"featureId":"VAR_063045","alternativeSequence":{"originalSequence":"N","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":2332,"modifier":"EXACT"},"end":{"value":2332,"modifier":"EXACT"}},"description":"in dbSNP:rs16888053","featureCrossReferences":[{"database":"dbSNP","id":"rs16888053"}],"featureId":"VAR_063046","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":2402,"modifier":"EXACT"},"end":{"value":7570,"modifier":"EXACT"}},"description":"in CMYO29; likely pathogenic","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"40497796"}],"featureId":"VAR_091647","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":3115,"modifier":"EXACT"},"end":{"value":7570,"modifier":"EXACT"}},"description":"in CMYO29; likely pathogenic","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"40497796"}],"featureId":"VAR_091648","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":3376,"modifier":"EXACT"},"end":{"value":7570,"modifier":"EXACT"}},"description":"in CMYO29; likely pathogenic","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"40497796"}],"featureId":"VAR_091649","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":3720,"modifier":"EXACT"},"end":{"value":3720,"modifier":"EXACT"}},"description":"in dbSNP:rs4712138","featureCrossReferences":[{"database":"dbSNP","id":"rs4712138"}],"featureId":"VAR_063047","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":5138,"modifier":"EXACT"},"end":{"value":5138,"modifier":"EXACT"}},"description":"in dbSNP:rs4715631","featureCrossReferences":[{"database":"dbSNP","id":"rs4715631"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14702039"}],"featureId":"VAR_063048","alternativeSequence":{"originalSequence":"T","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":5741,"modifier":"EXACT"},"end":{"value":7570,"modifier":"EXACT"}},"description":"in LCCS12; likely pathogenic","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"40497796"}],"featureId":"VAR_091650","alternativeSequence":{}},{"type":"Mutagenesis","location":{"start":{"value":7548,"modifier":"EXACT"},"end":{"value":7548,"modifier":"EXACT"}},"description":"Loss of interaction with MAPRE1 and association with microtubule growing ends.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19632184"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["Q"]}},{"type":"Mutagenesis","location":{"start":{"value":7550,"modifier":"EXACT"},"end":{"value":7550,"modifier":"EXACT"}},"description":"Loss of association with microtubule growing ends.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19632184"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["A","N"]}},{"type":"Mutagenesis","location":{"start":{"value":7552,"modifier":"EXACT"},"end":{"value":7552,"modifier":"EXACT"}},"description":"Loss of interaction with MAPRE1 and association with the growing microtubule plus ends; when associated with N-7553.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19632184"}],"alternativeSequence":{"originalSequence":"I","alternativeSequences":["N"]}},{"type":"Mutagenesis","location":{"start":{"value":7553,"modifier":"EXACT"},"end":{"value":7553,"modifier":"EXACT"}},"description":"Loss of interaction with MAPRE1 and association with the growing microtubule plus ends; when associated with N-7552.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19632184"}],"alternativeSequence":{"originalSequence":"P","alternativeSequences":["N"]}},{"type":"Mutagenesis","location":{"start":{"value":7557,"modifier":"EXACT"},"end":{"value":7557,"modifier":"EXACT"}},"description":"Loss of interaction with MAPRE1 and association with the growing microtubule plus ends.","alternativeSequence":{"originalSequence":"R","alternativeSequences":["N"]}},{"type":"Mutagenesis","location":{"start":{"value":7558,"modifier":"EXACT"},"end":{"value":7558,"modifier":"EXACT"}},"description":"Loss of interaction with MAPRE1 and association with the growing microtubule plus ends.","alternativeSequence":{"originalSequence":"K","alternativeSequences":["N"]}},{"type":"Sequence conflict","location":{"start":{"value":573,"modifier":"EXACT"},"end":{"value":573,"modifier":"EXACT"}},"description":"in Ref. 4; BAH12207","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"P","alternativeSequences":["A"]}},{"type":"Sequence conflict","location":{"start":{"value":1177,"modifier":"EXACT"},"end":{"value":1177,"modifier":"EXACT"}},"description":"in Ref. 1; M69225 and 3; AAL62061/AAL62062","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"V","alternativeSequences":["G"]}},{"type":"Sequence conflict","location":{"start":{"value":1363,"modifier":"EXACT"},"end":{"value":1363,"modifier":"EXACT"}},"description":"in Ref. 3; AAL62061","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["E"]}},{"type":"Sequence conflict","location":{"start":{"value":4703,"modifier":"EXACT"},"end":{"value":4703,"modifier":"EXACT"}},"description":"in Ref. 4; BAC04449","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["H"]}},{"type":"Sequence conflict","location":{"start":{"value":4935,"modifier":"EXACT"},"end":{"value":4935,"modifier":"EXACT"}},"description":"in Ref. 4; BAC04449","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"N","alternativeSequences":["S"]}},{"type":"Sequence conflict","location":{"start":{"value":5030,"modifier":"EXACT"},"end":{"value":5030,"modifier":"EXACT"}},"description":"in Ref. 3; AAL62061","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["G"]}},{"type":"Sequence conflict","location":{"start":{"value":5177,"modifier":"EXACT"},"end":{"value":5177,"modifier":"EXACT"}},"description":"in Ref. 3; AAL62061","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"Q","alternativeSequences":["R"]}},{"type":"Sequence conflict","location":{"start":{"value":5225,"modifier":"EXACT"},"end":{"value":5225,"modifier":"EXACT"}},"description":"in Ref. 4; BAB70870","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"M","alternativeSequences":["I"]}},{"type":"Sequence conflict","location":{"start":{"value":5299,"modifier":"EXACT"},"end":{"value":5299,"modifier":"EXACT"}},"description":"in Ref. 3; AAL62061","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["R"]}},{"type":"Sequence conflict","location":{"start":{"value":5823,"modifier":"EXACT"},"end":{"value":5823,"modifier":"EXACT"}},"description":"in Ref. 3; AAL62061","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"I","alternativeSequences":["V"]}},{"type":"Sequence conflict","location":{"start":{"value":5882,"modifier":"EXACT"},"end":{"value":5882,"modifier":"EXACT"}},"description":"in Ref. 3; AAL62061","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["R"]}},{"type":"Sequence conflict","location":{"start":{"value":5986,"modifier":"EXACT"},"end":{"value":5986,"modifier":"EXACT"}},"description":"in Ref. 3; AAL62061","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"L","alternativeSequences":["S"]}},{"type":"Sequence conflict","location":{"start":{"value":6080,"modifier":"EXACT"},"end":{"value":6080,"modifier":"EXACT"}},"description":"in Ref. 4; BAC04848","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["E"]}},{"type":"Sequence conflict","location":{"start":{"value":6186,"modifier":"EXACT"},"end":{"value":6186,"modifier":"EXACT"}},"description":"in Ref. 3; AAL62061","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["G"]}},{"type":"Sequence conflict","location":{"start":{"value":6440,"modifier":"EXACT"},"end":{"value":6440,"modifier":"EXACT"}},"description":"in Ref. 3; AAL62061","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"A","alternativeSequences":["G"]}},{"type":"Modified residue","location":{"start":{"value":1565,"modifier":"EXACT"},"end":{"value":1565,"modifier":"EXACT"},"sequence":"Q03001-3"},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Natural variant","location":{"start":{"value":1124,"modifier":"EXACT"},"end":{"value":2649,"modifier":"EXACT"},"sequence":"Q03001-3"},"description":"in EBS3; likely pathogenic","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20164846"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35276021"}],"featureId":"VAR_091651","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":1249,"modifier":"EXACT"},"end":{"value":2649,"modifier":"EXACT"},"sequence":"Q03001-3"},"description":"in EBS3; likely pathogenic","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22113475"}],"featureId":"VAR_091652","alternativeSequence":{}},{"type":"Sequence conflict","location":{"start":{"value":1644,"modifier":"EXACT"},"end":{"value":1644,"modifier":"EXACT"},"sequence":"Q03001-3"},"description":"in Ref. 1; M69225","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["T"]}},{"type":"Sequence conflict","location":{"start":{"value":1943,"modifier":"EXACT"},"end":{"value":1943,"modifier":"EXACT"},"sequence":"Q03001-3"},"description":"in Ref. 13; CAA41528","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"G","alternativeSequences":["R"]}},{"type":"Sequence conflict","location":{"start":{"value":2364,"modifier":"EXACT"},"end":{"value":2364,"modifier":"EXACT"},"sequence":"Q03001-3"},"description":"in Ref. 1; M69225","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["T"]}},{"type":"Sequence conflict","location":{"start":{"value":2495,"modifier":"EXACT"},"end":{"value":2495,"modifier":"EXACT"},"sequence":"Q03001-3"},"description":"in Ref. 1; M69225","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"G","alternativeSequences":["V"]}},{"type":"Sequence conflict","location":{"start":{"value":2543,"modifier":"EXACT"},"end":{"value":2543,"modifier":"EXACT"},"sequence":"Q03001-3"},"description":"in Ref. 1; M69225","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"N","alternativeSequences":["K"]}},{"type":"Sequence conflict","location":{"start":{"value":2621,"modifier":"EXACT"},"end":{"value":2621,"modifier":"EXACT"},"sequence":"Q03001-3"},"description":"in Ref. 1; M69225","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"A","alternativeSequences":["P"]}},{"type":"Modified residue","location":{"start":{"value":135,"modifier":"EXACT"},"end":{"value":135,"modifier":"EXACT"},"sequence":"Q03001-11"},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Sequence conflict","location":{"start":{"value":48,"modifier":"EXACT"},"end":{"value":48,"modifier":"EXACT"},"sequence":"Q03001-11"},"description":"in Ref. 7; AAC50244","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"P","alternativeSequences":["L"]}},{"type":"Modified residue","location":{"start":{"value":184,"modifier":"EXACT"},"end":{"value":184,"modifier":"EXACT"},"sequence":"Q03001-13"},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0009","category":"Molecular function","name":"Actin-binding"},{"id":"KW-0877","category":"Coding sequence diversity","name":"Alternative promoter usage"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0106","category":"Ligand","name":"Calcium"},{"id":"KW-0130","category":"Biological process","name":"Cell adhesion"},{"id":"KW-0965","category":"Cellular component","name":"Cell junction"},{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0206","category":"Cellular component","name":"Cytoskeleton"},{"id":"KW-0225","category":"Disease","name":"Disease variant"},{"id":"KW-0256","category":"Cellular component","name":"Endoplasmic reticulum"},{"id":"KW-0263","category":"Disease","name":"Epidermolysis bullosa"},{"id":"KW-0403","category":"Cellular component","name":"Intermediate filament"},{"id":"KW-1017","category":"PTM","name":"Isopeptide bond"},{"id":"KW-0449","category":"PTM","name":"Lipoprotein"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"id":"KW-0493","category":"Cellular component","name":"Microtubule"},{"id":"KW-0514","category":"Molecular function","name":"Muscle protein"},{"id":"KW-0523","category":"Disease","name":"Neurodegeneration"},{"id":"KW-0622","category":"Disease","name":"Neuropathy"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0564","category":"PTM","name":"Palmitate"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0677","category":"Domain","name":"Repeat"},{"id":"KW-0728","category":"Domain","name":"SH3 domain"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-0832","category":"PTM","name":"Ubl conjugation"}],"references":[{"referenceNumber":1,"citation":{"id":"1717441","citationType":"journal article","authors":["Sawamura D.","Li K.","Chu M.-L.","Uitto J."],"citationCrossReferences":[{"database":"PubMed","id":"1717441"},{"database":"DOI","id":"10.1016/s0021-9258(18)55195-4"}],"title":"Human bullous pemphigoid antigen (BPAG1). Amino acid sequences deduced from cloned cDNAs predict biologically important peptide segments and protein domains.","publicationDate":"1991","journal":"J. Biol. Chem.","firstPage":"17784","lastPage":"17790","volume":"266"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)","DISEASE"],"referenceComments":[{"value":"Keratinocyte","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"8345227","citationType":"journal article","authors":["Elgart G.W.","Stanley J.R."],"citationCrossReferences":[{"database":"PubMed","id":"8345227"},{"database":"DOI","id":"10.1111/1523-1747.ep12365083"}],"title":"Cloning of the 5' mRNA for the 230-kD bullous pemphigoid antigen by rapid amplification of cDNA ends.","publicationDate":"1993","journal":"J. Invest. Dermatol.","firstPage":"244","lastPage":"246","volume":"101"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)"],"referenceComments":[{"value":"Keratinocyte","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"11751855","citationType":"journal article","authors":["Okumura M.","Yamakawa H.","Ohara O.","Owaribe K."],"citationCrossReferences":[{"database":"PubMed","id":"11751855"},{"database":"DOI","id":"10.1074/jbc.m109209200"}],"title":"Novel alternative splicings of BPAG1 (bullous pemphigoid antigen 1) including the domain structure closely related to MACF (microtubule actin cross-linking factor).","publicationDate":"2002","journal":"J. Biol. Chem.","firstPage":"6682","lastPage":"6687","volume":"277"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)","NUCLEOTIDE SEQUENCE [MRNA] OF 1-3386 (ISOFORM 4)","SUBCELLULAR LOCATION","TISSUE SPECIFICITY"],"referenceComments":[{"value":"Keratinocyte","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 8)","NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4114-6568 (ISOFORM 1)","VARIANT ALA-5138"],"referenceComments":[{"value":"Brain","type":"TISSUE"},{"value":"Hippocampus","type":"TISSUE"},{"value":"Placenta","type":"TISSUE"},{"value":"Tongue","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"14574404","citationType":"journal article","authors":["Mungall A.J.","Palmer S.A.","Sims S.K.","Edwards C.A.","Ashurst J.L.","Wilming L.","Jones M.C.","Horton R.","Hunt S.E.","Scott C.E.","Gilbert J.G.R.","Clamp M.E.","Bethel G.","Milne S.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Andrews T.D.","Ashwell R.I.S.","Babbage A.K.","Bagguley C.L.","Bailey J.","Banerjee R.","Barker D.J.","Barlow K.F.","Bates K.","Beare D.M.","Beasley H.","Beasley O.","Bird C.P.","Blakey S.E.","Bray-Allen S.","Brook J.","Brown A.J.","Brown J.Y.","Burford D.C.","Burrill W.","Burton J.","Carder C.","Carter N.P.","Chapman J.C.","Clark S.Y.","Clark G.","Clee C.M.","Clegg S.","Cobley V.","Collier R.E.","Collins J.E.","Colman L.K.","Corby N.R.","Coville G.J.","Culley K.M.","Dhami P.","Davies J.","Dunn M.","Earthrowl M.E.","Ellington A.E.","Evans K.A.","Faulkner L.","Francis M.D.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Ghori M.J.","Gilby L.M.","Gillson C.J.","Glithero R.J.","Grafham D.V.","Grant M.","Gribble S.","Griffiths C.","Griffiths M.N.D.","Hall R.","Halls K.S.","Hammond S.","Harley J.L.","Hart E.A.","Heath P.D.","Heathcott R.","Holmes S.J.","Howden P.J.","Howe K.L.","Howell G.R.","Huckle E.","Humphray S.J.","Humphries M.D.","Hunt A.R.","Johnson C.M.","Joy A.A.","Kay M.","Keenan S.J.","Kimberley A.M.","King A.","Laird G.K.","Langford C.","Lawlor S.","Leongamornlert D.A.","Leversha M.","Lloyd C.R.","Lloyd D.M.","Loveland J.E.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","Maslen G.L.","Matthews L.","McCann O.T.","McLaren S.J.","McLay K.","McMurray A.","Moore M.J.F.","Mullikin J.C.","Niblett D.","Nickerson T.","Novik K.L.","Oliver K.","Overton-Larty E.K.","Parker A.","Patel R.","Pearce A.V.","Peck A.I.","Phillimore B.J.C.T.","Phillips S.","Plumb R.W.","Porter K.M.","Ramsey Y.","Ranby S.A.","Rice C.M.","Ross M.T.","Searle S.M.","Sehra H.K.","Sheridan E.","Skuce C.D.","Smith S.","Smith M.","Spraggon L.","Squares S.L.","Steward C.A.","Sycamore N.","Tamlyn-Hall G.","Tester J.","Theaker A.J.","Thomas D.W.","Thorpe A.","Tracey A.","Tromans A.","Tubby B.","Wall M.","Wallis J.M.","West A.P.","White S.S.","Whitehead S.L.","Whittaker H.","Wild A.","Willey D.J.","Wilmer T.E.","Wood J.M.","Wray P.W.","Wyatt J.C.","Young L.","Younger R.M.","Bentley D.R.","Coulson A.","Durbin R.M.","Hubbard T.","Sulston J.E.","Dunham I.","Rogers J.","Beck S."],"citationCrossReferences":[{"database":"PubMed","id":"14574404"},{"database":"DOI","id":"10.1038/nature02055"}],"title":"The DNA sequence and analysis of human chromosome 6.","publicationDate":"2003","journal":"Nature","firstPage":"805","lastPage":"811","volume":"425"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":6,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5)"],"referenceComments":[{"value":"Duodenum","type":"TISSUE"}]},{"referenceNumber":7,"citation":{"id":"8575775","citationType":"journal article","authors":["Brown A.","Dalpe G.","Mathieu M.","Kothary R."],"citationCrossReferences":[{"database":"PubMed","id":"8575775"},{"database":"DOI","id":"10.1006/geno.1995.9936"}],"title":"Cloning and characterization of the neural isoforms of human dystonin.","publicationDate":"1995","journal":"Genomics","firstPage":"777","lastPage":"780","volume":"29"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF 1-461 (ISOFORM 1)","NUCLEOTIDE SEQUENCE [MRNA] OF 1-46 (ISOFORM 6)"],"referenceComments":[{"value":"Fetal brain","type":"TISSUE"},{"value":"Retina","type":"TISSUE"}]},{"referenceNumber":8,"citation":{"id":"10428034","citationType":"journal article","authors":["Yang Y.","Bauer C.","Strasser G.","Wollman R.","Julien J.P.","Fuchs E."],"citationCrossReferences":[{"database":"PubMed","id":"10428034"},{"database":"DOI","id":"10.1016/s0092-8674(00)81017-x"}],"title":"Integrators of the cytoskeleton that stabilize microtubules.","publicationDate":"1999","journal":"Cell","firstPage":"229","lastPage":"238","volume":"98"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF 1-188 (ISOFORM 7)","ALTERNATIVE SPLICING (ISOFORMS 6 AND 7)","FUNCTION OF ISOFORMS 6 AND 7","SUBCELLULAR LOCATION (ISOFORMS 6 AND 7)"],"referenceComments":[{"value":"Fetal brain","type":"TISSUE"}]},{"referenceNumber":9,"citation":{"id":"CI-1SAM5PK7DBM2M","citationType":"submission","authors":["Geerts D.","Sonnenberg A."],"publicationDate":"APR-2001","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF 208-308 (ISOFORM 1)"],"referenceComments":[{"value":"Pineal gland","type":"TISSUE"}]},{"referenceNumber":10,"citation":{"id":"1712022","citationType":"journal article","authors":["Tanaka T.","Parry D.A.D.","Klaus-Kovtun V.","Steinert P.M.","Stanley J.R."],"citationCrossReferences":[{"database":"PubMed","id":"1712022"},{"database":"DOI","id":"10.1016/s0021-9258(18)98934-9"}],"title":"Comparison of molecularly cloned bullous pemphigoid antigen to desmoplakin I confirms that they define a new family of cell adhesion junction plaque proteins.","publicationDate":"1991","journal":"J. Biol. Chem.","firstPage":"12555","lastPage":"12559","volume":"266"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF 881-7570 (ISOFORM 3)"],"referenceComments":[{"value":"Keratinocyte","type":"TISSUE"}]},{"referenceNumber":11,"citation":{"id":"9872452","citationType":"journal article","authors":["Nagase T.","Ishikawa K.","Suyama M.","Kikuno R.","Miyajima N.","Tanaka A.","Kotani H.","Nomura N.","Ohara O."],"citationCrossReferences":[{"database":"PubMed","id":"9872452"},{"database":"DOI","id":"10.1093/dnares/5.5.277"}],"title":"Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.","publicationDate":"1998","journal":"DNA Res.","firstPage":"277","lastPage":"286","volume":"5"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 5947-7570 (ISOFORM 2)"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":12,"citation":{"id":"12168954","citationType":"journal article","authors":["Nakajima D.","Okazaki N.","Yamakawa H.","Kikuno R.","Ohara O.","Nagase T."],"citationCrossReferences":[{"database":"PubMed","id":"12168954"},{"database":"DOI","id":"10.1093/dnares/9.3.99"}],"title":"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.","publicationDate":"2002","journal":"DNA Res.","firstPage":"99","lastPage":"106","volume":"9"},"referencePositions":["SEQUENCE REVISION"]},{"referenceNumber":13,"citation":{"id":"2461961","citationType":"journal article","authors":["Stanley J.R.","Tanaka T.","Mueller S.","Klaus-Kovtun V.","Roop D."],"citationCrossReferences":[{"database":"PubMed","id":"2461961"},{"database":"DOI","id":"10.1172/jci113803"}],"title":"Isolation of complementary DNA for bullous pemphigoid antigen by use of patients' autoantibodies.","publicationDate":"1988","journal":"J. Clin. Invest.","firstPage":"1864","lastPage":"1870","volume":"82"},"referencePositions":["PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)"],"referenceComments":[{"value":"Keratinocyte","type":"TISSUE"}]},{"referenceNumber":14,"citation":{"id":"2090522","citationType":"journal article","authors":["Owaribe K.","Kartenbeck J.","Stumpp S.","Magin T.M.","Krieg T.","Diaz L.A.","Franke W.W."],"citationCrossReferences":[{"database":"PubMed","id":"2090522"},{"database":"DOI","id":"10.1111/j.1432-0436.1990.tb00475.x"}],"title":"The hemidesmosomal plaque. I. Characterization of a major constituent protein as a differentiation marker for certain forms of epithelia.","publicationDate":"1990","journal":"Differentiation","firstPage":"207","lastPage":"220","volume":"45"},"referencePositions":["PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)"]},{"referenceNumber":15,"citation":{"id":"8010969","citationType":"journal article","authors":["Hopkinson S.B.","Jones J.C."],"citationCrossReferences":[{"database":"PubMed","id":"8010969"},{"database":"DOI","id":"10.1042/bj3000851"}],"title":"Identification of a second protein product of the gene encoding a human epidermal autoantigen.","publicationDate":"1994","journal":"Biochem. J.","firstPage":"851","lastPage":"857","volume":"300"},"referencePositions":["PARTIAL NUCLEOTIDE SEQUENCE [GENOMIC DNA]","ALTERNATIVE SPLICING (ISOFORM 3)"]},{"referenceNumber":16,"citation":{"id":"8752219","citationType":"journal article","authors":["Yang Y.","Dowling J.","Yu Q.C.","Kouklis P.","Cleveland D.W.","Fuchs E."],"citationCrossReferences":[{"database":"PubMed","id":"8752219"},{"database":"DOI","id":"10.1016/s0092-8674(00)80138-5"}],"title":"An essential cytoskeletal linker protein connecting actin microfilaments to intermediate filaments.","publicationDate":"1996","journal":"Cell","firstPage":"655","lastPage":"665","volume":"86"},"referencePositions":["ALTERNATIVE SPLICING (ISOFORMS 3 AND 6)","TISSUE SPECIFICITY"]},{"referenceNumber":17,"citation":{"id":"10637308","citationType":"journal article","authors":["Hopkinson S.B.","Jones J.C."],"citationCrossReferences":[{"database":"PubMed","id":"10637308"},{"database":"DOI","id":"10.1091/mbc.11.1.277"}],"title":"The N terminus of the transmembrane protein BP180 interacts with the N-terminal domain of BP230, thereby mediating keratin cytoskeleton anchorage to the cell surface at the site of the hemidesmosome.","publicationDate":"2000","journal":"Mol. Biol. Cell","firstPage":"277","lastPage":"286","volume":"11"},"referencePositions":["ALTERNATIVE SPLICING (ISOFORM 3)","INTERACTION WITH COL17A1 AND ITGB4"]},{"referenceNumber":18,"citation":{"id":"8621649","citationType":"journal article","authors":["Tang H.-Y.","Chaffotte A.-F.","Thacher S.M."],"citationCrossReferences":[{"database":"PubMed","id":"8621649"},{"database":"DOI","id":"10.1074/jbc.271.16.9716"}],"title":"Structural analysis of the predicted coiled-coil rod domain of the cytoplasmic bullous pemphigoid antigen (BPAG1). Empirical localization of the N-terminal globular domain-rod boundary.","publicationDate":"1996","journal":"J. Biol. Chem.","firstPage":"9716","lastPage":"9722","volume":"271"},"referencePositions":["DOMAINS"]},{"referenceNumber":19,"citation":{"id":"11375975","citationType":"journal article","authors":["Favre B.","Fontao L.","Koster J.","Shafaatian R.","Jaunin F.","Saurat J.-H.","Sonnenberg A.","Borradori L."],"citationCrossReferences":[{"database":"PubMed","id":"11375975"},{"database":"DOI","id":"10.1074/jbc.m011005200"}],"title":"The hemidesmosomal protein bullous pemphigoid antigen 1 and the integrin beta 4 subunit bind to ERBIN. Molecular cloning of multiple alternative splice variants of ERBIN and analysis of their tissue expression.","publicationDate":"2001","journal":"J. Biol. Chem.","firstPage":"32427","lastPage":"32436","volume":"276"},"referencePositions":["INTERACTION WITH ITGB4 AND ERBIN"]},{"referenceNumber":20,"citation":{"id":"14581450","citationType":"journal article","authors":["Liu J.J.","Ding J.","Kowal A.S.","Nardine T.","Allen E.","Delcroix J.D.","Wu C.","Mobley W.","Fuchs E.","Yang Y."],"citationCrossReferences":[{"database":"PubMed","id":"14581450"},{"database":"DOI","id":"10.1083/jcb.200306075"}],"title":"BPAG1n4 is essential for retrograde axonal transport in sensory neurons.","publicationDate":"2003","journal":"J. Cell Biol.","firstPage":"223","lastPage":"229","volume":"163"},"referencePositions":["ALTERNATIVE SPLICING (ISOFORM 9)"]},{"referenceNumber":21,"citation":{"id":"12482924","citationType":"journal article","authors":["Koster J.","Geerts D.","Favre B.","Borradori L.","Sonnenberg A."],"citationCrossReferences":[{"database":"PubMed","id":"12482924"},{"database":"DOI","id":"10.1242/jcs.00241"}],"title":"Analysis of the interactions between BP180, BP230, plectin and the integrin alpha6beta4 important for hemidesmosome assembly.","publicationDate":"2003","journal":"J. Cell Sci.","firstPage":"387","lastPage":"399","volume":"116"},"referencePositions":["ALTERNATIVE SPLICING (ISOFORM 3)","FUNCTION OF ISOFORM 3","INTERACTION WITH COL17A1 AND ITGB4","SUBCELLULAR LOCATION (ISOFORM 3)"]},{"referenceNumber":22,"citation":{"id":"12802069","citationType":"journal article","authors":["Fontao L.","Favre B.","Riou S.","Geerts D.","Jaunin F.","Saurat J.H.","Green K.J.","Sonnenberg A.","Borradori L."],"citationCrossReferences":[{"database":"PubMed","id":"12802069"},{"database":"DOI","id":"10.1091/mbc.e02-08-0548"}],"title":"Interaction of the bullous pemphigoid antigen 1 (BP230) and desmoplakin with intermediate filaments is mediated by distinct sequences within their COOH terminus.","publicationDate":"2003","journal":"Mol. Biol. Cell","firstPage":"1978","lastPage":"1992","volume":"14"},"referencePositions":["ALTERNATIVE SPLICING (ISOFORM 3)","ASSOCIATION WITH KERATIN FILAMENTS","SUBCELLULAR LOCATION (ISOFORM 3)"]},{"referenceNumber":23,"citation":{"id":"18669648","citationType":"journal article","authors":["Dephoure N.","Zhou C.","Villen J.","Beausoleil S.A.","Bakalarski C.E.","Elledge S.J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"18669648"},{"database":"DOI","id":"10.1073/pnas.0805139105"}],"title":"A quantitative atlas of mitotic phosphorylation.","publicationDate":"2008","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10762","lastPage":"10767","volume":"105"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-7432","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":24,"citation":{"id":"19403692","citationType":"journal article","authors":["Hamill K.J.","Hopkinson S.B.","DeBiase P.","Jones J.C."],"citationCrossReferences":[{"database":"PubMed","id":"19403692"},{"database":"DOI","id":"10.1091/mbc.e09-01-0051"}],"title":"BPAG1e maintains keratinocyte polarity through beta4 integrin-mediated modulation of Rac1 and cofilin activities.","publicationDate":"2009","journal":"Mol. Biol. Cell","firstPage":"2954","lastPage":"2962","volume":"20"},"referencePositions":["ALTERNATIVE SPLICING (ISOFORM 3)","FUNCTION OF ISOFORM 3","SUBCELLULAR LOCATION (ISOFORM 3)"]},{"referenceNumber":25,"citation":{"id":"19932097","citationType":"journal article","authors":["Steiner-Champliaud M.F.","Schneider Y.","Favre B.","Paulhe F.","Praetzel-Wunder S.","Faulkner G.","Konieczny P.","Raith M.","Wiche G.","Adebola A.","Liem R.K.","Langbein L.","Sonnenberg A.","Fontao L.","Borradori L."],"citationCrossReferences":[{"database":"PubMed","id":"19932097"},{"database":"DOI","id":"10.1016/j.yexcr.2009.11.010"}],"title":"BPAG1 isoform-b: complex distribution pattern in striated and heart muscle and association with plectin and alpha-actinin.","publicationDate":"2010","journal":"Exp. Cell Res.","firstPage":"297","lastPage":"313","volume":"316"},"referencePositions":["ALTERNATIVE SPLICING (ISOFORM 1)","HOMODIMERIZATION","INTERACTION WITH ACTN2 AND PLEC","SUBCELLULAR LOCATION","TISSUE SPECIFICITY"]},{"referenceNumber":26,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Buerckstuemmer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":27,"citation":{"id":"21406692","citationType":"journal article","authors":["Rigbolt K.T.","Prokhorova T.A.","Akimov V.","Henningsen J.","Johansen P.T.","Kratchmarova I.","Kassem M.","Mann M.","Olsen J.V.","Blagoev B."],"citationCrossReferences":[{"database":"PubMed","id":"21406692"},{"database":"DOI","id":"10.1126/scisignal.2001570"}],"title":"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.","publicationDate":"2011","journal":"Sci. Signal.","firstPage":"RS3","lastPage":"RS3","volume":"4"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2919","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":28,"citation":{"id":"22522446","citationType":"journal article","authors":["Edvardson S.","Cinnamon Y.","Jalas C.","Shaag A.","Maayan C.","Axelrod F.B.","Elpeleg O."],"citationCrossReferences":[{"database":"PubMed","id":"22522446"},{"database":"DOI","id":"10.1002/ana.23524"}],"title":"Hereditary sensory autonomic neuropathy caused by a mutation in dystonin.","publicationDate":"2012","journal":"Ann. Neurol.","firstPage":"569","lastPage":"572","volume":"71"},"referencePositions":["INVOLVEMENT IN LCCS12"]},{"referenceNumber":29,"citation":{"id":"22419821","citationType":"journal article","authors":["Rahimi N.","Rezazadeh K.","Mahoney J.E.","Hartsough E.","Meyer R.D."],"citationCrossReferences":[{"database":"PubMed","id":"22419821"},{"database":"DOI","id":"10.1091/mbc.e11-11-0934"}],"title":"Identification of IGPR-1 as a novel adhesion molecule involved in angiogenesis.","publicationDate":"2012","journal":"Mol. Biol. Cell","firstPage":"1646","lastPage":"1656","volume":"23"},"referencePositions":["INTERACTION WITH TMIGD2"]},{"referenceNumber":30,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"},{"database":"DOI","id":"10.1021/pr300630k"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3968","PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-135 (ISOFORM 6)","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"},{"value":"Erythroleukemia","type":"TISSUE"}]},{"referenceNumber":31,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3968","PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-184 (ISOFORM 8)","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":32,"citation":{"id":"19632184","citationType":"journal article","authors":["Honnappa S.","Gouveia S.M.","Weisbrich A.","Damberger F.F.","Bhavesh N.S.","Jawhari H.","Grigoriev I.","van Rijssel F.J.","Buey R.M.","Lawera A.","Jelesarov I.","Winkler F.K.","Wuthrich K.","Akhmanova A.","Steinmetz M.O."],"citationCrossReferences":[{"database":"PubMed","id":"19632184"},{"database":"DOI","id":"10.1016/j.cell.2009.04.065"}],"title":"An EB1-binding motif acts as a microtubule tip localization signal.","publicationDate":"2009","journal":"Cell","firstPage":"366","lastPage":"376","volume":"138"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 7541-7570 IN COMPLEX WITH MAPRE1","DOMAIN MICROTUBULE TIP LOCALIZATION SIGNAL","MUTAGENESIS OF LYS-7548; SER-7550; ILE-7552; PRO-7553 AND 7557-ARG-LYS-7558"]},{"referenceNumber":33,"citation":{"id":"20164846","citationType":"journal article","authors":["Groves R.W.","Liu L.","Dopping-Hepenstal P.J.","Markus H.S.","Lovell P.A.","Ozoemena L.","Lai-Cheong J.E.","Gawler J.","Owaribe K.","Hashimoto T.","Mellerio J.E.","Mee J.B.","McGrath J.A."],"citationCrossReferences":[{"database":"PubMed","id":"20164846"},{"database":"DOI","id":"10.1038/jid.2010.19"}],"title":"A homozygous nonsense mutation within the dystonin gene coding for the coiled-coil domain of the epithelial isoform of BPAG1 underlies a new subtype of autosomal recessive epidermolysis bullosa simplex.","publicationDate":"2010","journal":"J. Invest. Dermatol.","firstPage":"1551","lastPage":"1557","volume":"130"},"referencePositions":["VARIANT EBS3 1124-GLN--SER-2649 DEL (ISOFORM 3)","INVOLVEMENT IN EBS3"]},{"referenceNumber":34,"citation":{"id":"22113475","citationType":"journal article","authors":["Liu L.","Dopping-Hepenstal P.J.","Lovell P.A.","Michael M.","Horn H.","Fong K.","Lai-Cheong J.E.","Mellerio J.E.","Parsons M.","McGrath J.A."],"citationCrossReferences":[{"database":"PubMed","id":"22113475"},{"database":"DOI","id":"10.1038/jid.2011.379"}],"title":"Autosomal recessive epidermolysis bullosa simplex due to loss of BPAG1-e expression.","publicationDate":"2012","journal":"J. Invest. Dermatol.","firstPage":"742","lastPage":"744","volume":"132"},"referencePositions":["VARIANT EBS3 1249-ARG--SER-2649 DEL (ISOFORM 3)","INVOLVEMENT IN EBS3"]},{"referenceNumber":35,"citation":{"id":"28767192","citationType":"journal article","authoringGroup":["TUDP"],"authors":["Cappuccio G.","Pinelli M.","Torella A.","Alagia M.","Auricchio R.","Staiano A.","Nigro V.","Brunetti-Pierri N."],"citationCrossReferences":[{"database":"PubMed","id":"28767192"},{"database":"DOI","id":"10.1002/ajmg.a.38367"}],"title":"Expanding the phenotype of DST-related disorder: A case report suggesting a genotype/phenotype correlation.","publicationDate":"2017","journal":"Am. J. Med. Genet. A","firstPage":"2743","lastPage":"2746","volume":"173"},"referencePositions":["VARIANTS HSAN6 ARG-91 AND 1118-ARG--ARG-7570 DEL","INVOLVEMENT IN HSAN6"]},{"referenceNumber":36,"citation":{"id":"31633269","citationType":"journal article","authoringGroup":["TUDP"],"authors":["Cappuccio G.","Pinelli M.","Torella A.","Alagia M.","Auricchio R.","Staiano A.","Nigro V.","Brunetti-Pierri N."],"citationCrossReferences":[{"database":"PubMed","id":"31633269"},{"database":"DOI","id":"10.1002/ajmg.a.61386"}],"title":"Expanding the phenotype of DST-related disorder: A case report suggesting a genotype/phenotype correlation.","publicationDate":"2020","journal":"Am. J. Med. Genet. A","firstPage":"268","lastPage":"268","volume":"182"},"referencePositions":["ERRATUM OF PUBMED:28767192"]},{"referenceNumber":37,"citation":{"id":"35276021","citationType":"journal article","authors":["Khalesi R.","Harvey N.","Garshasbi M.","Kalamati E.","Youssefian L.","Vahidnezhad H.","Uitto J."],"citationCrossReferences":[{"database":"PubMed","id":"35276021"},{"database":"DOI","id":"10.1111/exd.14562"}],"title":"Pathogenic DST sequence variants result in either epidermolysis bullosa simplex (EBS) or hereditary sensory and autonomic neuropathy type 6 (HSAN-VI).","publicationDate":"2022","journal":"Exp. Dermatol.","firstPage":"949","lastPage":"955","volume":"31"},"referencePositions":["VARIANT LCCS12 1091-ARG--ARG-7570 DEL","VARIANT EBS3 1124-GLN--SER-2649 DEL (ISOFORM 3)","INVOLVEMENT IN LCCS12","INVOLVEMENT IN EBS3"]},{"referenceNumber":38,"citation":{"id":"40497796","citationType":"journal article","authors":["Jacob M.","Koelbel H.","Harrer P.","Kopajtich R.","Munot P.","Achleitner M.T.","Badmann S.","Brugger M.","Brunet T.","Bonne G.","Codina M.","Ebner L.","Eshraghi P.","Eyring K.","Farhat A.S.","Feichtinger R.G.","Graf E.","Marce-Grau A.","Hahn A.","Houlden H.","Karimiani E.G.","Manel V.","Mayerhanser K.","Nectoux J.","Nelson I.","Phadke R.","Prokisch H.","Sadeghian S.","Saparov A.","Schaenzer A.","Schara-Schmidt U.","Schmidt J.","Schuler R.","Sewry C.","Shariati G.","Slanz S.","Smirnov D.","Sukenik-Halevy R.","Tajsharghi H.","Toosi M.B.","Trujillano L.","Weis J.","Wilson L.C.","Yaou R.B.","Zamani M.","Zech M.","Zschuentzsch J.","Kornak U.","Gomez-Andres D.","Maroofian R.","Winkelmann J.","Roos A.","Distelmaier F.","Mayr J.A.","Wagner M."],"citationCrossReferences":[{"database":"PubMed","id":"40497796"},{"database":"DOI","id":"10.1093/brain/awaf227"}],"title":"Deciphering DST-associated disorders: biallelic variants affecting DST-b cause a congenital myopathy.","publicationDate":"2026","journal":"Brain","firstPage":"653","lastPage":"667","volume":"149"},"referencePositions":["VARIANTS CMYO29 2402-TYR--ARG-7570 DEL; 3115-GLN--ARG-7570 DEL AND 3376-GLU--ARG-7570 DEL","VARIANTS LCCS12 1118-ARG--ARG-7570 DEL AND 5741-GLU--ARG-7570 DEL","INVOLVEMENT IN CMYO29","INVOLVEMENT IN LCCS12"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"M69225","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"L11690","properties":[{"key":"ProteinId","value":"AAA52288.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF400226","properties":[{"key":"ProteinId","value":"AAL62061.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF400227","properties":[{"key":"ProteinId","value":"AAL62062.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK055189","properties":[{"key":"ProteinId","value":"BAB70870.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK094883","properties":[{"key":"ProteinId","value":"BAC04449.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK096713","properties":[{"key":"ProteinId","value":"BAC04848.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK295864","properties":[{"key":"ProteinId","value":"BAH12207.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AL049215","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL096710","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL590005","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL137008","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL512422","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL512448","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL590037","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"KF458172","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC016991","properties":[{"key":"ProteinId","value":"AAH16991.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"U31850","properties":[{"key":"ProteinId","value":"AAC50243.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"U31851","properties":[{"key":"ProteinId","value":"AAC50244.1"},{"key":"Status","value":"ALT_FRAME"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF165191","properties":[{"key":"ProteinId","value":"AAD49334.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AY032900","properties":[{"key":"ProteinId","value":"AAK63130.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AY032901","properties":[{"key":"ProteinId","value":"AAK63131.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"M63618","properties":[{"key":"ProteinId","value":"AAA35606.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AB018271","properties":[{"key":"ProteinId","value":"BAA34448.2"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"M22942","properties":[{"key":"ProteinId","value":"AAA35538.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"X58677","properties":[{"key":"ProteinId","value":"CAA41528.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"U04850","properties":[{"key":"ProteinId","value":"AAA57184.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"U04850","properties":[{"key":"ProteinId","value":"AAA57185.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"CCDS","id":"CCDS47443.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q03001-8"},{"database":"CCDS","id":"CCDS4959.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q03001-3"},{"database":"CCDS","id":"CCDS93934.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q03001-14"},{"database":"PIR","id":"I56317","properties":[{"key":"EntryName","value":"A40937"}]},{"database":"RefSeq","id":"NP_001138241.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001144769.5"}]},{"database":"RefSeq","id":"NP_001138242.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001144770.2"}]},{"database":"RefSeq","id":"NP_001361659.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001374730.1"}],"isoformId":"Q03001-14"},{"database":"RefSeq","id":"NP_001714.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001723.7"}],"isoformId":"Q03001-3"},{"database":"RefSeq","id":"NP_056363.2","properties":[{"key":"NucleotideSequenceId","value":"NM_015548.5"}],"isoformId":"Q03001-8"},{"database":"RefSeq","id":"NP_899236.1","properties":[{"key":"NucleotideSequenceId","value":"NM_183380.4"}]},{"database":"PDB","id":"3GJO","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"E/F/G/H=7541-7570"}]},{"database":"PDB","id":"7OLG","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"C/D=7548-7558"}]},{"database":"PDBsum","id":"3GJO","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7OLG","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"Q03001","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q03001","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"107135","properties":[{"key":"Interactions","value":"327"}]},{"database":"DIP","id":"DIP-33131N","properties":[{"key":"Description","value":"-"}]},{"database":"ELM","id":"Q03001","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q03001","properties":[{"key":"Number of interactors","value":"1276"}]},{"database":"IntAct","id":"Q03001","properties":[{"key":"Interactions","value":"144"}]},{"database":"MINT","id":"Q03001","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-DST","properties":[{"key":"Evidences","value":"1 NDEx IQuery Curated Pathway"}]},{"database":"STRING","id":"9606.ENSP00000307959","properties":[{"key":"Description","value":"-"}]},{"database":"GlyCosmos","id":"Q03001","properties":[{"key":"glycosylation","value":"6 sites, 1 glycan"}]},{"database":"GlyGen","id":"Q03001","properties":[{"key":"glycosylation","value":"21 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (18 sites)"}]},{"database":"iPTMnet","id":"Q03001","properties":[{"key":"Description","value":"-"}]},{"database":"MetOSite","id":"Q03001","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q03001","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"Q03001","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"DST","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"294862529","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q03001","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q03001","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000307959","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q03001","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"17852","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"58151","properties":[{"key":"Description","value":"-"}],"isoformId":"Q03001-7"},{"database":"ProteomicsDB","id":"58152","properties":[{"key":"Description","value":"-"}],"isoformId":"Q03001-10"},{"database":"ProteomicsDB","id":"58153","properties":[{"key":"Description","value":"-"}],"isoformId":"Q03001-11"},{"database":"ProteomicsDB","id":"58154","properties":[{"key":"Description","value":"-"}],"isoformId":"Q03001-12"},{"database":"ProteomicsDB","id":"58155","properties":[{"key":"Description","value":"-"}],"isoformId":"Q03001-13"},{"database":"ProteomicsDB","id":"58156","properties":[{"key":"Description","value":"-"}],"isoformId":"Q03001-3"},{"database":"ProteomicsDB","id":"58157","properties":[{"key":"Description","value":"-"}],"isoformId":"Q03001-8"},{"database":"ProteomicsDB","id":"58158","properties":[{"key":"Description","value":"-"}],"isoformId":"Q03001-9"},{"database":"Pumba","id":"Q03001","properties":[{"key":"Description","value":"-"}]},{"database":"ABCD","id":"Q03001","properties":[{"key":"antibodies","value":"3 sequenced antibodies"}]},{"database":"Antibodypedia","id":"31066","properties":[{"key":"antibodies","value":"185 antibodies from 24 providers"}]},{"database":"DNASU","id":"667","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000244364.10","properties":[{"key":"ProteinId","value":"ENSP00000244364.6"},{"key":"GeneId","value":"ENSG00000151914.22"}],"isoformId":"Q03001-8"},{"database":"Ensembl","id":"ENST00000370765.11","properties":[{"key":"ProteinId","value":"ENSP00000359801.6"},{"key":"GeneId","value":"ENSG00000151914.22"}],"isoformId":"Q03001-3"},{"database":"Ensembl","id":"ENST00000370788.6","properties":[{"key":"ProteinId","value":"ENSP00000359824.2"},{"key":"GeneId","value":"ENSG00000151914.22"}],"isoformId":"Q03001-14"},{"database":"Ensembl","id":"ENST00000439203.5","properties":[{"key":"ProteinId","value":"ENSP00000404924.1"},{"key":"GeneId","value":"ENSG00000151914.22"}],"isoformId":"Q03001-9"},{"database":"GeneID","id":"667","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:667","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc003pcy.5","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"Q03001-7"},{"database":"AGR","id":"HGNC:1090","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA25399","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"667","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"667","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"DST","properties":[{"key":"Description","value":"-"}]},{"database":"GeneReviews","id":"DST","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:1090","properties":[{"key":"GeneName","value":"DST"}]},{"database":"HPA","id":"ENSG00000151914","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MalaCards","id":"DST","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"113810","properties":[{"key":"Type","value":"gene"}]},{"database":"MIM","id":"614653","properties":[{"key":"Type","value":"phenotype"}]},{"database":"MIM","id":"615425","properties":[{"key":"Type","value":"phenotype"}]},{"database":"MIM","id":"621510","properties":[{"key":"Type","value":"phenotype"}]},{"database":"MIM","id":"621511","properties":[{"key":"Type","value":"phenotype"}]},{"database":"OpenTargets","id":"ENSG00000151914","properties":[{"key":"Description","value":"-"}]},{"database":"Orphanet","id":"412181","properties":[{"key":"Disease","value":"Epidermolysis bullosa simplex due to BP230 deficiency"}]},{"database":"Orphanet","id":"314381","properties":[{"key":"Disease","value":"Hereditary sensory and autonomic neuropathy type 6"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000151914","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG0516","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"eggNOG","id":"KOG0517","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000155008","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_000015_3_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q03001","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"9479997at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q03001","properties":[{"key":"Number of GO annotations","value":"9 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q03001","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q03001","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-2022090","properties":[{"key":"PathwayName","value":"Assembly of collagen fibrils and other multimeric structures"}],"isoformId":"Q03001-3"},{"database":"Reactome","id":"R-HSA-446107","properties":[{"key":"PathwayName","value":"Type I hemidesmosome assembly"}]},{"database":"Reactome","id":"R-HSA-9013420","properties":[{"key":"PathwayName","value":"RHOU GTPase cycle"}]},{"database":"Reactome","id":"R-HSA-9013424","properties":[{"key":"PathwayName","value":"RHOV GTPase cycle"}]},{"database":"Reactome","id":"R-HSA-9696264","properties":[{"key":"PathwayName","value":"RND3 GTPase cycle"}]},{"database":"Reactome","id":"R-HSA-9696270","properties":[{"key":"PathwayName","value":"RND2 GTPase cycle"}]},{"database":"Reactome","id":"R-HSA-9696273","properties":[{"key":"PathwayName","value":"RND1 GTPase cycle"}]},{"database":"SignaLink","id":"Q03001","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"Q03001","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000151914","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"667","properties":[{"key":"hits","value":"16 hits in 1162 CRISPR screens"}]},{"database":"CD-CODE","id":"DEE660B4","properties":[{"key":"EntryName","value":"Stress granule"}]},{"database":"CD-CODE","id":"FB4E32DD","properties":[{"key":"EntryName","value":"Presynaptic clusters and postsynaptic densities"}]},{"database":"ChiTaRS","id":"DST","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"Q03001","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"Dystonin","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"667","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q03001","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:Q03001","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 6"}]},{"database":"RNAct","id":"Q03001","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000151914","properties":[{"key":"ExpressionPatterns","value":"Expressed in corpus callosum and 207 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q03001","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0015629","properties":[{"key":"GoTerm","value":"C:actin cytoskeleton"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}]},{"database":"GO","id":"GO:0030424","properties":[{"key":"GoTerm","value":"C:axon"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}]},{"database":"GO","id":"GO:1904115","properties":[{"key":"GoTerm","value":"C:axon cytoplasm"},{"key":"GoEvidenceType","value":"IEA:GOC"}]},{"database":"GO","id":"GO:0009925","properties":[{"key":"GoTerm","value":"C:basal plasma membrane"},{"key":"GoEvidenceType","value":"NAS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11375975"}]},{"database":"GO","id":"GO:0005604","properties":[{"key":"GoTerm","value":"C:basement membrane"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"2461961"}]},{"database":"GO","id":"GO:0005938","properties":[{"key":"GoTerm","value":"C:cell cortex"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0031252","properties":[{"key":"GoTerm","value":"C:cell leading edge"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19403692"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11751855"}]},{"database":"GO","id":"GO:0031410","properties":[{"key":"GoTerm","value":"C:cytoplasmic vesicle"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"14581450"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0005789","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum membrane"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0005925","properties":[{"key":"GoTerm","value":"C:focal adhesion"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"21423176"}]},{"database":"GO","id":"GO:0031673","properties":[{"key":"GoTerm","value":"C:H zone"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0030056","properties":[{"key":"GoTerm","value":"C:hemidesmosome"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}]},{"database":"GO","id":"GO:0045111","properties":[{"key":"GoTerm","value":"C:intermediate filament cytoskeleton"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0015630","properties":[{"key":"GoTerm","value":"C:microtubule cytoskeleton"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}]},{"database":"GO","id":"GO:0035371","properties":[{"key":"GoTerm","value":"C:microtubule plus-end"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19632184"}]},{"database":"GO","id":"GO:0005635","properties":[{"key":"GoTerm","value":"C:nuclear envelope"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"21630459"}]},{"database":"GO","id":"GO:0001725","properties":[{"key":"GoTerm","value":"C:stress fiber"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0030018","properties":[{"key":"GoTerm","value":"C:Z disc"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}]},{"database":"GO","id":"GO:0005509","properties":[{"key":"GoTerm","value":"F:calcium ion binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0005178","properties":[{"key":"GoTerm","value":"F:integrin binding"},{"key":"GoEvidenceType","value":"IPI:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"11375975"}]},{"database":"GO","id":"GO:0008017","properties":[{"key":"GoTerm","value":"F:microtubule binding"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0051010","properties":[{"key":"GoTerm","value":"F:microtubule plus-end binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19632184"}]},{"database":"GO","id":"GO:0042803","properties":[{"key":"GoTerm","value":"F:protein homodimerization activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}]},{"database":"GO","id":"GO:0005198","properties":[{"key":"GoTerm","value":"F:structural molecule activity"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0048870","properties":[{"key":"GoTerm","value":"P:cell motility"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"19403692"}]},{"database":"GO","id":"GO:0007010","properties":[{"key":"GoTerm","value":"P:cytoskeleton organization"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"19403692"}]},{"database":"GO","id":"GO:0031581","properties":[{"key":"GoTerm","value":"P:hemidesmosome assembly"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}]},{"database":"GO","id":"GO:0007229","properties":[{"key":"GoTerm","value":"P:integrin-mediated signaling pathway"},{"key":"GoEvidenceType","value":"NAS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11375975"}]},{"database":"GO","id":"GO:0045104","properties":[{"key":"GoTerm","value":"P:intermediate filament cytoskeleton organization"},{"key":"GoEvidenceType","value":"IEP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000270","source":"PubMed","id":"11751855"}]},{"database":"GO","id":"GO:0030011","properties":[{"key":"GoTerm","value":"P:maintenance of cell polarity"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"19403692"}]},{"database":"GO","id":"GO:0000226","properties":[{"key":"GoTerm","value":"P:microtubule cytoskeleton organization"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}]},{"database":"GO","id":"GO:0009611","properties":[{"key":"GoTerm","value":"P:response to wounding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19403692"}]},{"database":"GO","id":"GO:0008090","properties":[{"key":"GoTerm","value":"P:retrograde axonal transport"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0042060","properties":[{"key":"GoTerm","value":"P:wound healing"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"CDD","id":"cd21236","properties":[{"key":"EntryName","value":"CH_DYST_rpt1"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd21239","properties":[{"key":"EntryName","value":"CH_DYST_rpt2"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd00051","properties":[{"key":"EntryName","value":"EFh"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd00176","properties":[{"key":"EntryName","value":"SPEC"},{"key":"MatchStatus","value":"17"}]},{"database":"FunFam","id":"1.20.58.60:FF:000144","properties":[{"key":"EntryName","value":"Dystonin"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000185","properties":[{"key":"EntryName","value":"Dystonin"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.1290.10:FF:000022","properties":[{"key":"EntryName","value":"Dystonin"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000009","properties":[{"key":"EntryName","value":"dystonin isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000074","properties":[{"key":"EntryName","value":"dystonin isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000077","properties":[{"key":"EntryName","value":"dystonin isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000093","properties":[{"key":"EntryName","value":"dystonin isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000111","properties":[{"key":"EntryName","value":"dystonin isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000114","properties":[{"key":"EntryName","value":"dystonin isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000121","properties":[{"key":"EntryName","value":"dystonin isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.920.20:FF:000002","properties":[{"key":"EntryName","value":"dystonin isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000052","properties":[{"key":"EntryName","value":"dystonin isoform X2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000060","properties":[{"key":"EntryName","value":"dystonin isoform X2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000069","properties":[{"key":"EntryName","value":"dystonin isoform X2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000085","properties":[{"key":"EntryName","value":"dystonin isoform X2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000094","properties":[{"key":"EntryName","value":"dystonin isoform X2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000098","properties":[{"key":"EntryName","value":"dystonin isoform X3"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.1290.10:FF:000013","properties":[{"key":"EntryName","value":"dystonin isoform X7"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.1290.10:FF:000015","properties":[{"key":"EntryName","value":"dystonin isoform X7"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.238.10:FF:000013","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.418.10:FF:000002","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.418.10:FF:000017","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000001","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"3"}]},{"database":"FunFam","id":"1.20.58.60:FF:000012","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000016","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000021","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000022","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000027","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000031","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.30.30.40:FF:000011","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000008","properties":[{"key":"EntryName","value":"microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"2"}]},{"database":"FunFam","id":"1.20.58.60:FF:000014","properties":[{"key":"EntryName","value":"microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000025","properties":[{"key":"EntryName","value":"microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000010","properties":[{"key":"EntryName","value":"plectin isoform X2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.58.1060","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.58.60","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"31"}]},{"database":"Gene3D","id":"1.10.418.10","properties":[{"key":"EntryName","value":"Calponin-like domain"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"1.10.238.10","properties":[{"key":"EntryName","value":"EF-hand"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.920.20","properties":[{"key":"EntryName","value":"Gas2-like domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.90.1290.10","properties":[{"key":"EntryName","value":"Plakin repeat"},{"key":"MatchStatus","value":"3"}]},{"database":"Gene3D","id":"2.30.30.40","properties":[{"key":"EntryName","value":"SH3 Domains"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001589","properties":[{"key":"EntryName","value":"Actinin_actin-bd_CS"}]},{"database":"InterPro","id":"IPR001715","properties":[{"key":"EntryName","value":"CH_dom"}]},{"database":"InterPro","id":"IPR036872","properties":[{"key":"EntryName","value":"CH_dom_sf"}]},{"database":"InterPro","id":"IPR041615","properties":[{"key":"EntryName","value":"Desmoplakin_SH3"}]},{"database":"InterPro","id":"IPR041573","properties":[{"key":"EntryName","value":"Desmoplakin_Spectrin-like"}]},{"database":"InterPro","id":"IPR011992","properties":[{"key":"EntryName","value":"EF-hand-dom_pair"}]},{"database":"InterPro","id":"IPR018247","properties":[{"key":"EntryName","value":"EF_Hand_1_Ca_BS"}]},{"database":"InterPro","id":"IPR002048","properties":[{"key":"EntryName","value":"EF_hand_dom"}]},{"database":"InterPro","id":"IPR003108","properties":[{"key":"EntryName","value":"GAR_dom"}]},{"database":"InterPro","id":"IPR036534","properties":[{"key":"EntryName","value":"GAR_dom_sf"}]},{"database":"InterPro","id":"IPR049538","properties":[{"key":"EntryName","value":"PCN-like_spectrin-like_rpt"}]},{"database":"InterPro","id":"IPR043197","properties":[{"key":"EntryName","value":"Plakin"}]},{"database":"InterPro","id":"IPR035915","properties":[{"key":"EntryName","value":"Plakin_repeat_sf"}]},{"database":"InterPro","id":"IPR001101","properties":[{"key":"EntryName","value":"Plectin_repeat"}]},{"database":"InterPro","id":"IPR001452","properties":[{"key":"EntryName","value":"SH3_domain"}]},{"database":"InterPro","id":"IPR018159","properties":[{"key":"EntryName","value":"Spectrin/alpha-actinin"}]},{"database":"InterPro","id":"IPR002017","properties":[{"key":"EntryName","value":"Spectrin_repeat"}]},{"database":"PANTHER","id":"PTHR23169:SF24","properties":[{"key":"EntryName","value":"DYSTONIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR23169","properties":[{"key":"EntryName","value":"ENVOPLAKIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00307","properties":[{"key":"EntryName","value":"CH"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF13499","properties":[{"key":"EntryName","value":"EF-hand_7"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02187","properties":[{"key":"EntryName","value":"GAS2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00681","properties":[{"key":"EntryName","value":"Plectin"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF17902","properties":[{"key":"EntryName","value":"SH3_10"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00435","properties":[{"key":"EntryName","value":"Spectrin"},{"key":"MatchStatus","value":"20"}]},{"database":"Pfam","id":"PF18373","properties":[{"key":"EntryName","value":"Spectrin_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF21019","properties":[{"key":"EntryName","value":"Spectrin_3"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF21020","properties":[{"key":"EntryName","value":"Spectrin_4"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF27015","properties":[{"key":"EntryName","value":"SR_desmoplakin_3"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF21097","properties":[{"key":"EntryName","value":"SR_plectin_7"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00033","properties":[{"key":"EntryName","value":"CH"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00054","properties":[{"key":"EntryName","value":"EFh"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00243","properties":[{"key":"EntryName","value":"GAS2"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00250","properties":[{"key":"EntryName","value":"PLEC"},{"key":"MatchStatus","value":"8"}]},{"database":"SMART","id":"SM00150","properties":[{"key":"EntryName","value":"SPEC"},{"key":"MatchStatus","value":"32"}]},{"database":"SUPFAM","id":"SSF47576","properties":[{"key":"EntryName","value":"Calponin-homology domain, CH-domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF47473","properties":[{"key":"EntryName","value":"EF-hand"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF143575","properties":[{"key":"EntryName","value":"GAS2 domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF75399","properties":[{"key":"EntryName","value":"Plakin repeat"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF46966","properties":[{"key":"EntryName","value":"Spectrin repeat"},{"key":"MatchStatus","value":"29"}]},{"database":"PROSITE","id":"PS00019","properties":[{"key":"EntryName","value":"ACTININ_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00020","properties":[{"key":"EntryName","value":"ACTININ_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50021","properties":[{"key":"EntryName","value":"CH"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS00018","properties":[{"key":"EntryName","value":"EF_HAND_1"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS50222","properties":[{"key":"EntryName","value":"EF_HAND_2"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS51460","properties":[{"key":"EntryName","value":"GAR"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50002","properties":[{"key":"EntryName","value":"SH3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAGYLSPAAYLYVEEQEYLQAYEDVLERYKDERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPREKGRMRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGESEDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLANLEHAFYVAEKIGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPEGGEGIGANDVEVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKETEIPPKETEKSKIKRLYKLLEIWIEFGRIKLLQGYHPNDIEKEWGKLIIAMLEREKALRPEVERLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISGITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPSGLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKLDKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLKDAKSHGLIDEQILCQLKELSKAKEIISAASPTTIPVLDALAQSMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLKCGRNISILRAAHEGLIDRETMFRLLSAQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSILTYQVQTGGIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELITNELAYKILNGRQKIAALYIPESSQVIGLDAAKQLGIIDNNTASILKNITLPDKMPDLGDLEACKNARRWLSFCKFQPSTVHDYRQEEDVFDGEEPVTTQTSEETKKLFLSYLMINSYMDANTGQRLLLYDGDLDEAVGMLLEGCHAEFDGNTAIKECLDVLSSSGVFLNNASGREKDECTATPSSFNKCHCGEPEHEETPENRKCAIDEEFNEMRNTVINSEFSQSGKLASTISIDPKVNSSPSVCVPSLISYLTQTELADISMLRSDSENILTNYENQSRVETNERANECSHSKNIQNFPSDLIENPIMKSKMSKFCGVNETENEDNTNRDSPIFDYSPRLSALLSHDKLMHSQGSFNDTHTPESNGNKCEAPALSFSDKTMLSGQRIGEKFQDQFLGIAAINISLPGEQYGQKSLNMISSNPQVQYHNDKYISNTSGEDEKTHPGFQQMPEDKEDESEIEEYSCAVTPGGDTDNAIVSLTCATPLLDETISASDYETSLLNDQQNNTGTDTDSDDDFYDTPLFEDDDHDSLLLDGDDRDCLHPEDYDTLQEENDETASPADVFYDVSKENENSMVPQGAPVGSLSVKNKAHCLQDFLMDVEKDELDSGEKIHLNPVGSDKVNGQSLETGSERECTNILEGDESDSLTDYDIVGGKESFTASLKFDDSGSWRGRKEEYVTGQEFHSDTDHLDSMQSEESYGDYIYDSNDQDDDDDDGIDEEGGGIRDENGKPRCQNVAEDMDIQLCASILNENSDENENINTMILLDKMHSCSSLEKQQRVNVVQLASPSENNLVTEKSNLPEYTTEIAGKSKENLLNHEMVLKDVLPPIIKDTESEKTFGPASISHDNNNISSTSELGTDLANTKVKLIQGSELPELTDSVKGKDEYFKNMTPKVDSSLDHIICTEPDLIGKPAEESHLSLIASVTDKDPQGNGSDLIKGRDGKSDILIEDETSIQKMYLGEGEVLVEGLVEEENRHLKLLPGKNTRDSFKLINSQFPFPQITNNEELNQKGSLKKATVTLKDEPNNLQIIVSKSPVQFENLEEIFDTSVSKEISDDITSDITSWEGNTHFEESFTDGPEKELDLFTYLKHCAKNIKAKDVAKPNEDVPSHVLITAPPMKEHLQLGVNNTKEKSTSTQKDSPLNDMIQSNDLCSKESISGGGTEISQFTPESIEATLSILSRKHVEDVGKNDFLQSERCANGLGNDNSSNTLNTDYSFLEINNKKERIEQQLPKEQALSPRSQEKEVQIPELSQVFVEDVKDILKSRLKEGHMNPQEVEEPSACADTKILIQNLIKRITTSQLVNEASTVPSDSQMSDSSGVSPMTNSSELKPESRDDPFCIGNLKSELLLNILKQDQHSQKITGVFELMRELTHMEYDLEKRGITSKVLPLQLENIFYKLLADGYSEKIEHVGDFNQKACSTSEMMEEKPHILGDIKSKEGNYYSPNLETVKEIGLESSTVWASTLPRDEKLKDLCNDFPSHLECTSGSKEMASGDSSTEQFSSELQQCLQHTEKMHEYLTLLQDMKPPLDNQESLDNNLEALKNQLRQLETFELGLAPIAVILRKDMKLAEEFLKSLPSDFPRGHVEELSISHQSLKTAFSSLSNVSSERTKQIMLAIDSEMSKLAVSHEEFLHKLKSFSDWVSEKSKSVKDIEIVNVQDSEYVKKRLEFLKNVLKDLGHTKMQLETTAFDVQFFISEYAQDLSPNQSKQLLRLLNTTQKCFLDVQESVTTQVERLETQLHLEQDLDDQKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAALHPNKDAYKPITDADKIEDEVTRQVAKCKCAKRFQVEQIGDNKYRFFLGNQFGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCRVHHHGSKMLRSESNSSITTTQPTIAKGRTNMELREKFILADGASQGMAAFRPRGRRSRPSSRGASPNRSTSVSSQAAQAASPQVPATTTPKGTPIQGSKLRLPGYLSGKGFHSGEDSGLITTAAARVRTQFADSKKTPSRPGSRAGSKAGSRASSRRGSDASDFDISEIQSVCSDVETVPQTHRPTPRAGSRPSTAKPSKIPTPQRKSPASKLDKSSKR","length":7570,"molWeight":860662,"crc64":"1EA992E53D1C243E","md5":"9E277C69776471344A04D286CF1903EC"},"extraAttributes":{"countByCommentType":{"FUNCTION":4,"SUBUNIT":1,"INTERACTION":5,"SUBCELLULAR LOCATION":7,"ALTERNATIVE PRODUCTS":9,"TISSUE SPECIFICITY":1,"DOMAIN":2,"DISEASE":4,"MISCELLANEOUS":5,"SEQUENCE CAUTION":7},"countByFeatureType":{"Chain":1,"Domain":6,"Repeat":37,"Region":8,"Motif":2,"Compositional bias":10,"Binding site":10,"Modified residue":14,"Cross-link":1,"Alternative sequence":19,"Natural variant":13,"Mutagenesis":6,"Sequence conflict":22},"uniParcId":"UPI0001CE9367"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"F8W9J4","uniProtkbId":"F8W9J4_HUMAN","entryAudit":{"firstPublicDate":"2011-09-21","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-09-21","entryVersion":106,"sequenceVersion":1},"annotationScore":4.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000354508.3"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00072808"}],"value":"Dystonin"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00077378"}],"value":"Bullous pemphigoid antigen 1"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00075126"}],"value":"Dystonia musculorum protein"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00077918"}],"value":"Hemidesmosomal plaque protein"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000354508.3"}],"value":"DST"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00054620"}],"value":"Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Mediates docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport through its interaction with TMEM108 and DCTN1"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00055817"}],"value":"Plays a structural role in the assembly of hemidesmosomes of epithelial cells; anchors keratin-containing intermediate filaments to the inner plaque of hemidesmosomes. Required for the regulation of keratinocyte polarity and motility; mediates integrin ITGB4 regulation of RAC1 activity"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00057123"}],"value":"Required for bundling actin filaments around the nucleus"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00060371"}],"value":"Cell junction, hemidesmosome","id":"SL-0137"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004193"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004193"}],"value":"Lipid-anchor","id":"SL-9901"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004489"}],"value":"Cell projection, axon","id":"SL-0279"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004544"}],"value":"Cytoplasm, cell cortex","id":"SL-0138"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004529"}],"value":"Cytoplasm, cytoskeleton, stress fiber","id":"SL-0501"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00060430"}],"value":"Cytoplasm, myofibril, sarcomere, H zone","id":"SL-0477"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004216"}],"value":"Cytoplasm, myofibril, sarcomere, Z line","id":"SL-0314"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004389"}],"value":"Endoplasmic reticulum membrane","id":"SL-0097"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004389"}],"value":"Single-pass membrane protein","id":"SL-9904"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004259"}],"value":"Nucleus envelope","id":"SL-0178"}}]}],"features":[{"type":"Domain","location":{"start":{"value":35,"modifier":"EXACT"},"end":{"value":138,"modifier":"EXACT"}},"description":"Calponin-homology (CH)","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50021"}]},{"type":"Domain","location":{"start":{"value":151,"modifier":"EXACT"},"end":{"value":255,"modifier":"EXACT"}},"description":"Calponin-homology (CH)","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50021"}]},{"type":"Domain","location":{"start":{"value":887,"modifier":"EXACT"},"end":{"value":944,"modifier":"EXACT"}},"description":"SH3","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50002"}]},{"type":"Domain","location":{"start":{"value":7088,"modifier":"EXACT"},"end":{"value":7123,"modifier":"EXACT"}},"description":"EF-hand","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50222"}]},{"type":"Domain","location":{"start":{"value":7124,"modifier":"EXACT"},"end":{"value":7159,"modifier":"EXACT"}},"description":"EF-hand","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50222"}]},{"type":"Domain","location":{"start":{"value":7164,"modifier":"EXACT"},"end":{"value":7242,"modifier":"EXACT"}},"description":"GAR","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51460"}]},{"type":"Region","location":{"start":{"value":2317,"modifier":"EXACT"},"end":{"value":2346,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":2383,"modifier":"EXACT"},"end":{"value":2422,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":2585,"modifier":"EXACT"},"end":{"value":2616,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":3190,"modifier":"EXACT"},"end":{"value":3221,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":7249,"modifier":"EXACT"},"end":{"value":7270,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":7286,"modifier":"EXACT"},"end":{"value":7343,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":7372,"modifier":"EXACT"},"end":{"value":7461,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":12,"modifier":"EXACT"},"end":{"value":39,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":734,"modifier":"EXACT"},"end":{"value":768,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":1208,"modifier":"EXACT"},"end":{"value":1242,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":1418,"modifier":"EXACT"},"end":{"value":1448,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":1504,"modifier":"EXACT"},"end":{"value":1531,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":3723,"modifier":"EXACT"},"end":{"value":3757,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":3939,"modifier":"EXACT"},"end":{"value":3966,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":4346,"modifier":"EXACT"},"end":{"value":4373,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":4558,"modifier":"EXACT"},"end":{"value":4585,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":4772,"modifier":"EXACT"},"end":{"value":4833,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":5057,"modifier":"EXACT"},"end":{"value":5131,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":5204,"modifier":"EXACT"},"end":{"value":5286,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":6085,"modifier":"EXACT"},"end":{"value":6112,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":6191,"modifier":"EXACT"},"end":{"value":6235,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":6337,"modifier":"EXACT"},"end":{"value":6375,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":6846,"modifier":"EXACT"},"end":{"value":6876,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Compositional bias","location":{"start":{"value":2336,"modifier":"EXACT"},"end":{"value":2345,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":2385,"modifier":"EXACT"},"end":{"value":2394,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":2395,"modifier":"EXACT"},"end":{"value":2412,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":2591,"modifier":"EXACT"},"end":{"value":2605,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":3192,"modifier":"EXACT"},"end":{"value":3209,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":7253,"modifier":"EXACT"},"end":{"value":7265,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":7302,"modifier":"EXACT"},"end":{"value":7332,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":7381,"modifier":"EXACT"},"end":{"value":7395,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":7410,"modifier":"EXACT"},"end":{"value":7426,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023203"}],"id":"KW-0009","category":"Molecular function","name":"Actin-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022837"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10142"}],"id":"KW-0106","category":"Ligand","name":"Calcium"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022889"}],"id":"KW-0130","category":"Biological process","name":"Cell adhesion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022949"}],"id":"KW-0965","category":"Cellular component","name":"Cell junction"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023273"}],"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023054"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00792"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023212"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00792"}],"id":"KW-0206","category":"Cellular component","name":"Cytoskeleton"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022824"}],"id":"KW-0256","category":"Cellular component","name":"Endoplasmic reticulum"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022754"}],"id":"KW-0403","category":"Cellular component","name":"Intermediate filament"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022499"}],"id":"KW-1017","category":"PTM","name":"Isopeptide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023288"}],"id":"KW-0449","category":"PTM","name":"Lipoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10142"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022701"}],"id":"KW-0493","category":"Cellular component","name":"Microtubule"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023179"}],"id":"KW-0514","category":"Molecular function","name":"Muscle protein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023139"}],"id":"KW-0564","category":"PTM","name":"Palmitate"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"F8W9J4"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"F8W9J4"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022443"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00192"}],"id":"KW-0728","category":"Domain","name":"SH3 domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022843"}],"id":"KW-0832","category":"PTM","name":"Ubl conjugation"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000354508.3"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"14574404","citationType":"journal article","authors":["Mungall A.J.","Palmer S.A.","Sims S.K.","Edwards C.A.","Ashurst J.L.","Wilming L.","Jones M.C.","Horton R.","Hunt S.E.","Scott C.E.","Gilbert J.G.","Clamp M.E.","Bethel G.","Milne S.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Andrews T.D.","Ashwell R.I.","Babbage A.K.","Bagguley C.L.","Bailey J.","Banerjee R.","Barker D.J.","Barlow K.F.","Bates K.","Beare D.M.","Beasley H.","Beasley O.","Bird C.P.","Blakey S.","Bray-Allen S.","Brook J.","Brown A.J.","Brown J.Y.","Burford D.C.","Burrill W.","Burton J.","Carder C.","Carter N.P.","Chapman J.C.","Clark S.Y.","Clark G.","Clee C.M.","Clegg S.","Cobley V.","Collier R.E.","Collins J.E.","Colman L.K.","Corby N.R.","Coville G.J.","Culley K.M.","Dhami P.","Davies J.","Dunn M.","Earthrowl M.E.","Ellington A.E.","Evans K.A.","Faulkner L.","Francis M.D.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Ghori M.J.","Gilby L.M.","Gillson C.J.","Glithero R.J.","Grafham D.V.","Grant M.","Gribble S.","Griffiths C.","Griffiths M.","Hall R.","Halls K.S.","Hammond S.","Harley J.L.","Hart E.A.","Heath P.D.","Heathcott R.","Holmes S.J.","Howden P.J.","Howe K.L.","Howell G.R.","Huckle E.","Humphray S.J.","Humphries M.D.","Hunt A.R.","Johnson C.M.","Joy A.A.","Kay M.","Keenan S.J.","Kimberley A.M.","King A.","Laird G.K.","Langford C.","Lawlor S.","Leongamornlert D.A.","Leversha M.","Lloyd C.R.","Lloyd D.M.","Loveland J.E.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","Maslen G.L.","Matthews L.","McCann O.T.","McLaren S.J.","McLay K.","McMurray A.","Moore M.J.","Mullikin J.C.","Niblett D.","Nickerson T.","Novik K.L.","Oliver K.","Overton-Larty E.K.","Parker A.","Patel R.","Pearce A.V.","Peck A.I.","Phillimore B.","Phillips S.","Plumb R.W.","Porter K.M.","Ramsey Y.","Ranby S.A.","Rice C.M.","Ross M.T.","Searle S.M.","Sehra H.K.","Sheridan E.","Skuce C.D.","Smith S.","Smith M.","Spraggon L.","Squares S.L.","Steward C.A.","Sycamore N.","Tamlyn-Hall G.","Tester J.","Theaker A.J.","Thomas D.W.","Thorpe A.","Tracey A.","Tromans A.","Tubby B.","Wall M.","Wallis J.M.","West A.P.","White S.S.","Whitehead S.L.","Whittaker H.","Wild A.","Willey D.J.","Wilmer T.E.","Wood J.M.","Wray P.W.","Wyatt J.C.","Young L.","Younger R.M.","Bentley D.R.","Coulson A.","Durbin R.","Hubbard T.","Sulston J.E.","Dunham I.","Rogers J.","Beck S."],"citationCrossReferences":[{"database":"PubMed","id":"14574404"},{"database":"DOI","id":"10.1038/nature02055"}],"title":"The DNA sequence and analysis of human chromosome 6.","publicationDate":"2003","journal":"Nature","firstPage":"805","lastPage":"811","volume":"425"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000354508.3"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000354508.3"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"18669648","citationType":"journal article","authors":["Dephoure N.","Zhou C.","Villen J.","Beausoleil S.A.","Bakalarski C.E.","Elledge S.J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"18669648"},{"database":"DOI","id":"10.1073/pnas.0805139105"}],"title":"A quantitative atlas of mitotic phosphorylation.","publicationDate":"2008","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10762","lastPage":"10767","volume":"105"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"18669648"}]},{"referenceNumber":5,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Burckstummer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"21269460"}]},{"referenceNumber":6,"citation":{"id":"21406692","citationType":"journal article","authors":["Rigbolt K.T.","Prokhorova T.A.","Akimov V.","Henningsen J.","Johansen P.T.","Kratchmarova I.","Kassem M.","Mann M.","Olsen J.V.","Blagoev B."],"citationCrossReferences":[{"database":"PubMed","id":"21406692"},{"database":"DOI","id":"10.1126/scisignal.2001570"}],"title":"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.","publicationDate":"2011","journal":"Sci. Signal.","firstPage":"RS3","lastPage":"RS3","volume":"4"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"21406692"}]},{"referenceNumber":7,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"23186163"}]},{"referenceNumber":8,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"24275569"}]},{"referenceNumber":9,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000354508.3"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL096710","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL137008","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL512422","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL512448","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL590005","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL590037","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"KF458172","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"NP_001361658.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001374729.1"}]},{"database":"SMR","id":"F8W9J4","properties":[{"key":"Description","value":"-"}]},{"database":"IntAct","id":"F8W9J4","properties":[{"key":"Interactions","value":"1"}]},{"database":"SwissPalm","id":"F8W9J4","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"F8W9J4","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"30335","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"31066","properties":[{"key":"antibodies","value":"185 antibodies from 24 providers"}]},{"database":"Ensembl","id":"ENST00000361203.7","properties":[{"key":"ProteinId","value":"ENSP00000354508.3"},{"key":"GeneId","value":"ENSG00000151914.22"}]},{"database":"GeneID","id":"667","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc063peq.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"CTD","id":"667","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:1090","properties":[{"key":"GeneName","value":"DST"}]},{"database":"OpenTargets","id":"ENSG00000151914","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000151914","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000155008","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_000015_0_1_1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"9479997at2759","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"667","properties":[{"key":"hits","value":"16 hits in 1162 CRISPR screens"}]},{"database":"ChiTaRS","id":"DST","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 6"}]},{"database":"Bgee","id":"ENSG00000151914","properties":[{"key":"ExpressionPatterns","value":"Expressed in corpus callosum and 207 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"F8W9J4","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0030424","properties":[{"key":"GoTerm","value":"C:axon"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005938","properties":[{"key":"GoTerm","value":"C:cell cortex"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0031252","properties":[{"key":"GoTerm","value":"C:cell leading edge"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0005789","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0031673","properties":[{"key":"GoTerm","value":"C:H zone"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0030056","properties":[{"key":"GoTerm","value":"C:hemidesmosome"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0045111","properties":[{"key":"GoTerm","value":"C:intermediate filament cytoskeleton"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0015630","properties":[{"key":"GoTerm","value":"C:microtubule cytoskeleton"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0005635","properties":[{"key":"GoTerm","value":"C:nuclear envelope"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0099513","properties":[{"key":"GoTerm","value":"C:polymeric cytoskeletal fiber"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0001725","properties":[{"key":"GoTerm","value":"C:stress fiber"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0030018","properties":[{"key":"GoTerm","value":"C:Z disc"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005509","properties":[{"key":"GoTerm","value":"F:calcium ion binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0008017","properties":[{"key":"GoTerm","value":"F:microtubule binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0042803","properties":[{"key":"GoTerm","value":"F:protein homodimerization activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0045104","properties":[{"key":"GoTerm","value":"P:intermediate filament cytoskeleton organization"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0000226","properties":[{"key":"GoTerm","value":"P:microtubule cytoskeleton organization"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd21236","properties":[{"key":"EntryName","value":"CH_DYST_rpt1"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd21239","properties":[{"key":"EntryName","value":"CH_DYST_rpt2"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd00051","properties":[{"key":"EntryName","value":"EFh"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd00176","properties":[{"key":"EntryName","value":"SPEC"},{"key":"MatchStatus","value":"16"}]},{"database":"FunFam","id":"1.20.58.60:FF:000144","properties":[{"key":"EntryName","value":"Dystonin"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000185","properties":[{"key":"EntryName","value":"Dystonin"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.1290.10:FF:000022","properties":[{"key":"EntryName","value":"Dystonin"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000009","properties":[{"key":"EntryName","value":"dystonin isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000074","properties":[{"key":"EntryName","value":"dystonin isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000077","properties":[{"key":"EntryName","value":"dystonin isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000093","properties":[{"key":"EntryName","value":"dystonin isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000111","properties":[{"key":"EntryName","value":"dystonin isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000114","properties":[{"key":"EntryName","value":"dystonin isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000121","properties":[{"key":"EntryName","value":"dystonin isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.920.20:FF:000002","properties":[{"key":"EntryName","value":"dystonin isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000052","properties":[{"key":"EntryName","value":"dystonin isoform X2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000060","properties":[{"key":"EntryName","value":"dystonin isoform X2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000069","properties":[{"key":"EntryName","value":"dystonin isoform X2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000085","properties":[{"key":"EntryName","value":"dystonin isoform X2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000094","properties":[{"key":"EntryName","value":"dystonin isoform X2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000098","properties":[{"key":"EntryName","value":"dystonin isoform X3"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.1290.10:FF:000013","properties":[{"key":"EntryName","value":"dystonin isoform X7"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.1290.10:FF:000015","properties":[{"key":"EntryName","value":"dystonin isoform X7"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.238.10:FF:000013","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.418.10:FF:000002","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.418.10:FF:000017","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000001","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"3"}]},{"database":"FunFam","id":"1.20.58.60:FF:000008","properties":[{"key":"EntryName","value":"microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000012","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000014","properties":[{"key":"EntryName","value":"microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000016","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000021","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000022","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000025","properties":[{"key":"EntryName","value":"microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000027","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000031","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.30.30.40:FF:000011","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000010","properties":[{"key":"EntryName","value":"plectin isoform X2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.58.1060","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.58.60","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"30"}]},{"database":"Gene3D","id":"1.10.418.10","properties":[{"key":"EntryName","value":"Calponin-like domain"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"1.10.238.10","properties":[{"key":"EntryName","value":"EF-hand"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.920.20","properties":[{"key":"EntryName","value":"Gas2-like domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.90.1290.10","properties":[{"key":"EntryName","value":"Plakin repeat"},{"key":"MatchStatus","value":"3"}]},{"database":"Gene3D","id":"2.30.30.40","properties":[{"key":"EntryName","value":"SH3 Domains"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001589","properties":[{"key":"EntryName","value":"Actinin_actin-bd_CS"}]},{"database":"InterPro","id":"IPR001715","properties":[{"key":"EntryName","value":"CH_dom"}]},{"database":"InterPro","id":"IPR036872","properties":[{"key":"EntryName","value":"CH_dom_sf"}]},{"database":"InterPro","id":"IPR041615","properties":[{"key":"EntryName","value":"Desmoplakin_SH3"}]},{"database":"InterPro","id":"IPR041573","properties":[{"key":"EntryName","value":"Desmoplakin_Spectrin-like"}]},{"database":"InterPro","id":"IPR011992","properties":[{"key":"EntryName","value":"EF-hand-dom_pair"}]},{"database":"InterPro","id":"IPR018247","properties":[{"key":"EntryName","value":"EF_Hand_1_Ca_BS"}]},{"database":"InterPro","id":"IPR002048","properties":[{"key":"EntryName","value":"EF_hand_dom"}]},{"database":"InterPro","id":"IPR003108","properties":[{"key":"EntryName","value":"GAR_dom"}]},{"database":"InterPro","id":"IPR036534","properties":[{"key":"EntryName","value":"GAR_dom_sf"}]},{"database":"InterPro","id":"IPR049538","properties":[{"key":"EntryName","value":"PCN-like_spectrin-like_rpt"}]},{"database":"InterPro","id":"IPR043197","properties":[{"key":"EntryName","value":"Plakin"}]},{"database":"InterPro","id":"IPR035915","properties":[{"key":"EntryName","value":"Plakin_repeat_sf"}]},{"database":"InterPro","id":"IPR001101","properties":[{"key":"EntryName","value":"Plectin_repeat"}]},{"database":"InterPro","id":"IPR001452","properties":[{"key":"EntryName","value":"SH3_domain"}]},{"database":"InterPro","id":"IPR018159","properties":[{"key":"EntryName","value":"Spectrin/alpha-actinin"}]},{"database":"InterPro","id":"IPR002017","properties":[{"key":"EntryName","value":"Spectrin_repeat"}]},{"database":"PANTHER","id":"PTHR23169:SF24","properties":[{"key":"EntryName","value":"DYSTONIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR23169","properties":[{"key":"EntryName","value":"ENVOPLAKIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00307","properties":[{"key":"EntryName","value":"CH"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF13499","properties":[{"key":"EntryName","value":"EF-hand_7"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02187","properties":[{"key":"EntryName","value":"GAS2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00681","properties":[{"key":"EntryName","value":"Plectin"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF17902","properties":[{"key":"EntryName","value":"SH3_10"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00435","properties":[{"key":"EntryName","value":"Spectrin"},{"key":"MatchStatus","value":"20"}]},{"database":"Pfam","id":"PF18373","properties":[{"key":"EntryName","value":"Spectrin_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF21019","properties":[{"key":"EntryName","value":"Spectrin_3"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF21020","properties":[{"key":"EntryName","value":"Spectrin_4"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF27015","properties":[{"key":"EntryName","value":"SR_desmoplakin_3"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF21097","properties":[{"key":"EntryName","value":"SR_plectin_7"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00033","properties":[{"key":"EntryName","value":"CH"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00054","properties":[{"key":"EntryName","value":"EFh"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00243","properties":[{"key":"EntryName","value":"GAS2"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00250","properties":[{"key":"EntryName","value":"PLEC"},{"key":"MatchStatus","value":"8"}]},{"database":"SMART","id":"SM00150","properties":[{"key":"EntryName","value":"SPEC"},{"key":"MatchStatus","value":"31"}]},{"database":"SUPFAM","id":"SSF47576","properties":[{"key":"EntryName","value":"Calponin-homology domain, CH-domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF47473","properties":[{"key":"EntryName","value":"EF-hand"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF143575","properties":[{"key":"EntryName","value":"GAS2 domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF75399","properties":[{"key":"EntryName","value":"Plakin repeat"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF46966","properties":[{"key":"EntryName","value":"Spectrin repeat"},{"key":"MatchStatus","value":"27"}]},{"database":"PROSITE","id":"PS00019","properties":[{"key":"EntryName","value":"ACTININ_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00020","properties":[{"key":"EntryName","value":"ACTININ_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50021","properties":[{"key":"EntryName","value":"CH"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS00018","properties":[{"key":"EntryName","value":"EF_HAND_1"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS50222","properties":[{"key":"EntryName","value":"EF_HAND_2"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS51460","properties":[{"key":"EntryName","value":"GAR"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50002","properties":[{"key":"EntryName","value":"SH3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAGYLSPAAYLYVEEQEYLQAYEDVLERYKDERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPREKGRMRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGESEDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLANLEHAFYVAEKIGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPEGGEGIGANDVEVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKETEIPPKETEKSKIKRLYKLLEIWIEFGRIKLLQGYHPNDIEKEWGKLIIAMLEREKALRPEVERLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISGITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPSGLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKLDKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLKDAKSHGLIDEQILCQLKELSKAKEIISAASPTTIPVLDALAQSMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLKCGRNISILRAAHEGLIDRETMFRLLSAQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSILTYQVQTGGIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELITNELAYKILNGRQKIAALYIPESSQVIGLDAAKQLGIIDNNTASILKNITLPDKMPDLGDLEACKNARRWLSFCKFQPSTVHDYRQEEDVFDGEEPVTTQTSEETKKLFLSYLMINSYMDANTGQRLLLYDGDLDEAVGMLLEGCHAEFDGNTAIKECLDVLSSSGVFLNNASGREKDECTATPSSFNKCHCGEPEHEETPENRKCAIDEEFNEMRNTVINSEFSQSGKLASTISIDPKVNSSPSVCVPSLISYLTQTELADISMLRSDSENILTNYENQSRVETNERANECSHSKNIQNFPSDLIENPIMKSKMSKFCGVNETENEDNTNRDSPIFDYSPRLSALLSHDKLMHSQGSFNDTHTPESNGNKCEAPALSFSDKTMLSGQRIGEKFQDQFLGIAAINISLPGEQYGQKSLNMISSNPQVQYHNDKYISNTSGEDEKTHPGFQQMPEDKEDESEIEEYSCAVTPGGDTDNAIVSLTCATPLLDETISASDYETSLLNDQQNNTGTDTDSDDDFYDTPLFEDDDHDSLLLDGDDRDCLHPEDYDTLQEENDETASPADVFYDVSKENENSMVPQGAPVGSLSVKNKAHCLQDFLMDVEKDELDSGEKIHLNPVGSDKVNGQSLETGSERECTNILEGDESDSLTDYDIVGGKESFTASLKFDDSGSWRGRKEEYVTGQEFHSDTDHLDSMQSEESYGDYIYDSNDQDDDDDDGIDEEGGGIRDENGKPRCQNVAEDMDIQLCASILNENSDENENINTMILLDKMHSCSSLEKQQRVNVVQLASPSENNLVTEKSNLPEYTTEIAGKSKENLLNHEMVLKDVLPPIIKDTESEKTFGPASISHDNNNISSTSELGTDLANTKVKLIQGSELPELTDSVKGKDEYFKNMTPKVDSSLDHIICTEPDLIGKPAEESHLSLIASVTDKDPQGNGSDLIKGRDGKSDILIEDETSIQKMYLGEGEVLVEGLVEEENRHLKLLPGKNTRDSFKLINSQFPFPQITNNEELNQKGSLKKATVTLKDEPNNLQIIVSKSPVQFENLEEIFDTSVSKEISDDITSDITSWEGNTHFEESFTDGPEKELDLFTYLKHCAKNIKAKDVAKPNEDVPSHVLITAPPMKEHLQLGVNNTKEKSTSTQKDSPLNDMIQSNDLCSKESISGGGTEISQFTPESIEATLSILSRKHVEDVGKNDFLQSERCANGLGNDNSSNTLNTDYSFLEINNKKERIEQQLPKEQALSPRSQEKEVQIPELSQVFVEDVKDILKSRLKEGHMNPQEVEEPSACADTKILIQNLIKRITTSQLVNEASTVPSDSQMSDSSGVSPMTNSSELKPESRDDPFCIGNLKSELLLNILKQDQHSQKITGVFELMRELTHMEYDLEKRGITSKVLPLQLENIFYKLLADGYSEKIEHVGDFNQKACSTSEMMEEKPHILGDIKSKEGNYYSPNLETVKEIGLESSTVWASTLPRDEKLKDLCNDFPSHLECTSGSKEMASGDSSTEQFSSELQQCLQHTEKMHEYLTLLQDMKPPLDNQESLDNNLEALKNQLRQLETFELGLAPIAVILRKDMKLAEEFLKSLPSDFPRGHVEELSISHQSLKTAFSSLSNVSSERTKQIMLAIDSEMSKLAVSHEEFLHKLKSFSDWVSEKSKSVKDIEIVNVQDSEYVKKRLEFLKNVLKDLGHTKMQLETTAFDVQFFISEYAQDLSPNQSKQLLRLLNTTQKCFLDVQESVTTQVERLETQLHLEQDLDDQKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAALHPNKDAYKPITDADKIEDEVTRQVAKCKCAKRFQVEQIGDNKYRFFLGNQFGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCRVHHHGSKMLRSESNSSITTTQPTIAKGRTNMELREKFILADGASQGMAAFRPRGRRSRPSSRGASPNRSTSVSSQAAQAASPQVPATTTPKGTPIQGSKLRLPGYLSGKGFHSGEDSGLITTAAARVRTQFADSKKTPSRPGSRAGSKAGSRASSRRGSDASDFDISEIQSVCSDVETVPQTHRPTPRAGSRPSTAKPSKIPTPQRKSPASKLDKSSKR","length":7461,"molWeight":847971,"crc64":"96DC92B65F844758","md5":"C2326A9A77F730766EC88CF2AB8BDFE0"},"extraAttributes":{"countByCommentType":{"FUNCTION":3,"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Domain":6,"Region":7,"Coiled coil":16,"Compositional bias":9},"uniParcId":"UPI0001E8F797"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"E9PHM6","uniProtkbId":"E9PHM6_HUMAN","entryAudit":{"firstPublicDate":"2011-04-05","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2014-10-29","entryVersion":104,"sequenceVersion":3},"annotationScore":4.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000400883.3"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00072808"}],"value":"Dystonin"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00077378"}],"value":"Bullous pemphigoid antigen 1"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00075126"}],"value":"Dystonia musculorum protein"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00077918"}],"value":"Hemidesmosomal plaque protein"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000400883.3"}],"value":"DST"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00054620"}],"value":"Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Mediates docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport through its interaction with TMEM108 and DCTN1"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00055817"}],"value":"Plays a structural role in the assembly of hemidesmosomes of epithelial cells; anchors keratin-containing intermediate filaments to the inner plaque of hemidesmosomes. Required for the regulation of keratinocyte polarity and motility; mediates integrin ITGB4 regulation of RAC1 activity"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00057123"}],"value":"Required for bundling actin filaments around the nucleus"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00060371"}],"value":"Cell junction, hemidesmosome","id":"SL-0137"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004193"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004193"}],"value":"Lipid-anchor","id":"SL-9901"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004489"}],"value":"Cell projection, axon","id":"SL-0279"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004544"}],"value":"Cytoplasm, cell cortex","id":"SL-0138"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004529"}],"value":"Cytoplasm, cytoskeleton, stress fiber","id":"SL-0501"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00060430"}],"value":"Cytoplasm, myofibril, sarcomere, H zone","id":"SL-0477"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004216"}],"value":"Cytoplasm, myofibril, sarcomere, Z line","id":"SL-0314"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004389"}],"value":"Endoplasmic reticulum membrane","id":"SL-0097"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004389"}],"value":"Single-pass membrane protein","id":"SL-9904"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004259"}],"value":"Nucleus envelope","id":"SL-0178"}}]}],"features":[{"type":"Domain","location":{"start":{"value":35,"modifier":"EXACT"},"end":{"value":138,"modifier":"EXACT"}},"description":"Calponin-homology (CH)","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50021"}]},{"type":"Domain","location":{"start":{"value":151,"modifier":"EXACT"},"end":{"value":255,"modifier":"EXACT"}},"description":"Calponin-homology (CH)","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50021"}]},{"type":"Domain","location":{"start":{"value":887,"modifier":"EXACT"},"end":{"value":944,"modifier":"EXACT"}},"description":"SH3","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50002"}]},{"type":"Domain","location":{"start":{"value":5111,"modifier":"EXACT"},"end":{"value":5146,"modifier":"EXACT"}},"description":"EF-hand","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50222"}]},{"type":"Domain","location":{"start":{"value":5147,"modifier":"EXACT"},"end":{"value":5182,"modifier":"EXACT"}},"description":"EF-hand","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50222"}]},{"type":"Domain","location":{"start":{"value":5187,"modifier":"EXACT"},"end":{"value":5265,"modifier":"EXACT"}},"description":"GAR","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51460"}]},{"type":"Region","location":{"start":{"value":5289,"modifier":"EXACT"},"end":{"value":5338,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":5408,"modifier":"EXACT"},"end":{"value":5497,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":12,"modifier":"EXACT"},"end":{"value":39,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":734,"modifier":"EXACT"},"end":{"value":768,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":1208,"modifier":"EXACT"},"end":{"value":1242,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":1418,"modifier":"EXACT"},"end":{"value":1448,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":1504,"modifier":"EXACT"},"end":{"value":1531,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":1637,"modifier":"EXACT"},"end":{"value":1671,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":1853,"modifier":"EXACT"},"end":{"value":1880,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":2260,"modifier":"EXACT"},"end":{"value":2287,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":2472,"modifier":"EXACT"},"end":{"value":2499,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":2686,"modifier":"EXACT"},"end":{"value":2747,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":2971,"modifier":"EXACT"},"end":{"value":3045,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":3118,"modifier":"EXACT"},"end":{"value":3200,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":4108,"modifier":"EXACT"},"end":{"value":4135,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":4214,"modifier":"EXACT"},"end":{"value":4258,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":4360,"modifier":"EXACT"},"end":{"value":4398,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":4869,"modifier":"EXACT"},"end":{"value":4899,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Compositional bias","location":{"start":{"value":5301,"modifier":"EXACT"},"end":{"value":5331,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":5417,"modifier":"EXACT"},"end":{"value":5431,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":5446,"modifier":"EXACT"},"end":{"value":5462,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023203"}],"id":"KW-0009","category":"Molecular function","name":"Actin-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022837"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10142"}],"id":"KW-0106","category":"Ligand","name":"Calcium"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022889"}],"id":"KW-0130","category":"Biological process","name":"Cell adhesion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022949"}],"id":"KW-0965","category":"Cellular component","name":"Cell junction"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023273"}],"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023054"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00792"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023212"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00792"}],"id":"KW-0206","category":"Cellular component","name":"Cytoskeleton"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022824"}],"id":"KW-0256","category":"Cellular component","name":"Endoplasmic reticulum"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022754"}],"id":"KW-0403","category":"Cellular component","name":"Intermediate filament"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022499"}],"id":"KW-1017","category":"PTM","name":"Isopeptide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023288"}],"id":"KW-0449","category":"PTM","name":"Lipoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10142"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022701"}],"id":"KW-0493","category":"Cellular component","name":"Microtubule"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023179"}],"id":"KW-0514","category":"Molecular function","name":"Muscle protein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023139"}],"id":"KW-0564","category":"PTM","name":"Palmitate"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"E9PHM6"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"E9PHM6"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022443"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00192"}],"id":"KW-0728","category":"Domain","name":"SH3 domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022843"}],"id":"KW-0832","category":"PTM","name":"Ubl conjugation"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000400883.3"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"14574404","citationType":"journal article","authors":["Mungall A.J.","Palmer S.A.","Sims S.K.","Edwards C.A.","Ashurst J.L.","Wilming L.","Jones M.C.","Horton R.","Hunt S.E.","Scott C.E.","Gilbert J.G.","Clamp M.E.","Bethel G.","Milne S.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Andrews T.D.","Ashwell R.I.","Babbage A.K.","Bagguley C.L.","Bailey J.","Banerjee R.","Barker D.J.","Barlow K.F.","Bates K.","Beare D.M.","Beasley H.","Beasley O.","Bird C.P.","Blakey S.","Bray-Allen S.","Brook J.","Brown A.J.","Brown J.Y.","Burford D.C.","Burrill W.","Burton J.","Carder C.","Carter N.P.","Chapman J.C.","Clark S.Y.","Clark G.","Clee C.M.","Clegg S.","Cobley V.","Collier R.E.","Collins J.E.","Colman L.K.","Corby N.R.","Coville G.J.","Culley K.M.","Dhami P.","Davies J.","Dunn M.","Earthrowl M.E.","Ellington A.E.","Evans K.A.","Faulkner L.","Francis M.D.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Ghori M.J.","Gilby L.M.","Gillson C.J.","Glithero R.J.","Grafham D.V.","Grant M.","Gribble S.","Griffiths C.","Griffiths M.","Hall R.","Halls K.S.","Hammond S.","Harley J.L.","Hart E.A.","Heath P.D.","Heathcott R.","Holmes S.J.","Howden P.J.","Howe K.L.","Howell G.R.","Huckle E.","Humphray S.J.","Humphries M.D.","Hunt A.R.","Johnson C.M.","Joy A.A.","Kay M.","Keenan S.J.","Kimberley A.M.","King A.","Laird G.K.","Langford C.","Lawlor S.","Leongamornlert D.A.","Leversha M.","Lloyd C.R.","Lloyd D.M.","Loveland J.E.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","Maslen G.L.","Matthews L.","McCann O.T.","McLaren S.J.","McLay K.","McMurray A.","Moore M.J.","Mullikin J.C.","Niblett D.","Nickerson T.","Novik K.L.","Oliver K.","Overton-Larty E.K.","Parker A.","Patel R.","Pearce A.V.","Peck A.I.","Phillimore B.","Phillips S.","Plumb R.W.","Porter K.M.","Ramsey Y.","Ranby S.A.","Rice C.M.","Ross M.T.","Searle S.M.","Sehra H.K.","Sheridan E.","Skuce C.D.","Smith S.","Smith M.","Spraggon L.","Squares S.L.","Steward C.A.","Sycamore N.","Tamlyn-Hall G.","Tester J.","Theaker A.J.","Thomas D.W.","Thorpe A.","Tracey A.","Tromans A.","Tubby B.","Wall M.","Wallis J.M.","West A.P.","White S.S.","Whitehead S.L.","Whittaker H.","Wild A.","Willey D.J.","Wilmer T.E.","Wood J.M.","Wray P.W.","Wyatt J.C.","Young L.","Younger R.M.","Bentley D.R.","Coulson A.","Durbin R.","Hubbard T.","Sulston J.E.","Dunham I.","Rogers J.","Beck S."],"citationCrossReferences":[{"database":"PubMed","id":"14574404"},{"database":"DOI","id":"10.1038/nature02055"}],"title":"The DNA sequence and analysis of human chromosome 6.","publicationDate":"2003","journal":"Nature","firstPage":"805","lastPage":"811","volume":"425"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000400883.3"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000400883.3"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"18669648","citationType":"journal article","authors":["Dephoure N.","Zhou C.","Villen J.","Beausoleil S.A.","Bakalarski C.E.","Elledge S.J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"18669648"},{"database":"DOI","id":"10.1073/pnas.0805139105"}],"title":"A quantitative atlas of mitotic phosphorylation.","publicationDate":"2008","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10762","lastPage":"10767","volume":"105"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"18669648"}]},{"referenceNumber":5,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Burckstummer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"21269460"}]},{"referenceNumber":6,"citation":{"id":"21406692","citationType":"journal article","authors":["Rigbolt K.T.","Prokhorova T.A.","Akimov V.","Henningsen J.","Johansen P.T.","Kratchmarova I.","Kassem M.","Mann M.","Olsen J.V.","Blagoev B."],"citationCrossReferences":[{"database":"PubMed","id":"21406692"},{"database":"DOI","id":"10.1126/scisignal.2001570"}],"title":"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.","publicationDate":"2011","journal":"Sci. Signal.","firstPage":"RS3","lastPage":"RS3","volume":"4"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"21406692"}]},{"referenceNumber":7,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"23186163"}]},{"referenceNumber":8,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"24275569"}]},{"referenceNumber":9,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000400883.3"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL096710","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL137008","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL512422","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL512448","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL590005","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL590037","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"KF458172","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"NP_899236.1","properties":[{"key":"NucleotideSequenceId","value":"NM_183380.4"}]},{"database":"SMR","id":"E9PHM6","properties":[{"key":"Description","value":"-"}]},{"database":"IntAct","id":"E9PHM6","properties":[{"key":"Interactions","value":"1"}]},{"database":"SwissPalm","id":"E9PHM6","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"E9PHM6","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"20567","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"31066","properties":[{"key":"antibodies","value":"185 antibodies from 24 providers"}]},{"database":"DNASU","id":"667","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000421834.7","properties":[{"key":"ProteinId","value":"ENSP00000400883.3"},{"key":"GeneId","value":"ENSG00000151914.22"}]},{"database":"GeneID","id":"667","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc021zaz.3","properties":[{"key":"OrganismName","value":"human"}]},{"database":"CTD","id":"667","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"667","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:1090","properties":[{"key":"GeneName","value":"DST"}]},{"database":"OpenTargets","id":"ENSG00000151914","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000151914","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000155008","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"9479997at2759","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"667","properties":[{"key":"hits","value":"16 hits in 1162 CRISPR screens"}]},{"database":"ChiTaRS","id":"DST","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 6"}]},{"database":"Bgee","id":"ENSG00000151914","properties":[{"key":"ExpressionPatterns","value":"Expressed in corpus callosum and 207 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"E9PHM6","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0030424","properties":[{"key":"GoTerm","value":"C:axon"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005938","properties":[{"key":"GoTerm","value":"C:cell cortex"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0031252","properties":[{"key":"GoTerm","value":"C:cell leading edge"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0005789","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0031673","properties":[{"key":"GoTerm","value":"C:H zone"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0030056","properties":[{"key":"GoTerm","value":"C:hemidesmosome"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0045111","properties":[{"key":"GoTerm","value":"C:intermediate filament cytoskeleton"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0015630","properties":[{"key":"GoTerm","value":"C:microtubule cytoskeleton"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0005635","properties":[{"key":"GoTerm","value":"C:nuclear envelope"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0099513","properties":[{"key":"GoTerm","value":"C:polymeric cytoskeletal fiber"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0001725","properties":[{"key":"GoTerm","value":"C:stress fiber"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0030018","properties":[{"key":"GoTerm","value":"C:Z disc"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005509","properties":[{"key":"GoTerm","value":"F:calcium ion binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0008017","properties":[{"key":"GoTerm","value":"F:microtubule binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0042803","properties":[{"key":"GoTerm","value":"F:protein homodimerization activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0045104","properties":[{"key":"GoTerm","value":"P:intermediate filament cytoskeleton organization"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0000226","properties":[{"key":"GoTerm","value":"P:microtubule cytoskeleton organization"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd21236","properties":[{"key":"EntryName","value":"CH_DYST_rpt1"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd21239","properties":[{"key":"EntryName","value":"CH_DYST_rpt2"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd00051","properties":[{"key":"EntryName","value":"EFh"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd00176","properties":[{"key":"EntryName","value":"SPEC"},{"key":"MatchStatus","value":"16"}]},{"database":"FunFam","id":"1.20.58.60:FF:000144","properties":[{"key":"EntryName","value":"Dystonin"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000185","properties":[{"key":"EntryName","value":"Dystonin"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000009","properties":[{"key":"EntryName","value":"dystonin isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000074","properties":[{"key":"EntryName","value":"dystonin isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000077","properties":[{"key":"EntryName","value":"dystonin isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000093","properties":[{"key":"EntryName","value":"dystonin isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000111","properties":[{"key":"EntryName","value":"dystonin isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000114","properties":[{"key":"EntryName","value":"dystonin isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000121","properties":[{"key":"EntryName","value":"dystonin isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000052","properties":[{"key":"EntryName","value":"dystonin isoform X2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000060","properties":[{"key":"EntryName","value":"dystonin isoform X2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000069","properties":[{"key":"EntryName","value":"dystonin isoform X2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000085","properties":[{"key":"EntryName","value":"dystonin isoform X2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000094","properties":[{"key":"EntryName","value":"dystonin isoform X2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000098","properties":[{"key":"EntryName","value":"dystonin isoform X3"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.238.10:FF:000013","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.418.10:FF:000002","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.418.10:FF:000017","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000001","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"3"}]},{"database":"FunFam","id":"1.20.58.60:FF:000008","properties":[{"key":"EntryName","value":"microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"2"}]},{"database":"FunFam","id":"1.20.58.60:FF:000012","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000014","properties":[{"key":"EntryName","value":"microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000016","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000021","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000022","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000025","properties":[{"key":"EntryName","value":"microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000027","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000031","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.30.30.40:FF:000011","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.920.20:FF:000001","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000010","properties":[{"key":"EntryName","value":"plectin isoform X2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.58.1060","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.58.60","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"30"}]},{"database":"Gene3D","id":"1.10.418.10","properties":[{"key":"EntryName","value":"Calponin-like domain"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"1.10.238.10","properties":[{"key":"EntryName","value":"EF-hand"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.920.20","properties":[{"key":"EntryName","value":"Gas2-like domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.30.30.40","properties":[{"key":"EntryName","value":"SH3 Domains"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001589","properties":[{"key":"EntryName","value":"Actinin_actin-bd_CS"}]},{"database":"InterPro","id":"IPR001715","properties":[{"key":"EntryName","value":"CH_dom"}]},{"database":"InterPro","id":"IPR036872","properties":[{"key":"EntryName","value":"CH_dom_sf"}]},{"database":"InterPro","id":"IPR041615","properties":[{"key":"EntryName","value":"Desmoplakin_SH3"}]},{"database":"InterPro","id":"IPR041573","properties":[{"key":"EntryName","value":"Desmoplakin_Spectrin-like"}]},{"database":"InterPro","id":"IPR011992","properties":[{"key":"EntryName","value":"EF-hand-dom_pair"}]},{"database":"InterPro","id":"IPR018247","properties":[{"key":"EntryName","value":"EF_Hand_1_Ca_BS"}]},{"database":"InterPro","id":"IPR002048","properties":[{"key":"EntryName","value":"EF_hand_dom"}]},{"database":"InterPro","id":"IPR003108","properties":[{"key":"EntryName","value":"GAR_dom"}]},{"database":"InterPro","id":"IPR036534","properties":[{"key":"EntryName","value":"GAR_dom_sf"}]},{"database":"InterPro","id":"IPR049538","properties":[{"key":"EntryName","value":"PCN-like_spectrin-like_rpt"}]},{"database":"InterPro","id":"IPR043197","properties":[{"key":"EntryName","value":"Plakin"}]},{"database":"InterPro","id":"IPR001452","properties":[{"key":"EntryName","value":"SH3_domain"}]},{"database":"InterPro","id":"IPR018159","properties":[{"key":"EntryName","value":"Spectrin/alpha-actinin"}]},{"database":"InterPro","id":"IPR002017","properties":[{"key":"EntryName","value":"Spectrin_repeat"}]},{"database":"PANTHER","id":"PTHR23169:SF24","properties":[{"key":"EntryName","value":"DYSTONIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR23169","properties":[{"key":"EntryName","value":"ENVOPLAKIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00307","properties":[{"key":"EntryName","value":"CH"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF13499","properties":[{"key":"EntryName","value":"EF-hand_7"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02187","properties":[{"key":"EntryName","value":"GAS2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF17902","properties":[{"key":"EntryName","value":"SH3_10"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00435","properties":[{"key":"EntryName","value":"Spectrin"},{"key":"MatchStatus","value":"21"}]},{"database":"Pfam","id":"PF18373","properties":[{"key":"EntryName","value":"Spectrin_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF21019","properties":[{"key":"EntryName","value":"Spectrin_3"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF21020","properties":[{"key":"EntryName","value":"Spectrin_4"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF27015","properties":[{"key":"EntryName","value":"SR_desmoplakin_3"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF21097","properties":[{"key":"EntryName","value":"SR_plectin_7"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00033","properties":[{"key":"EntryName","value":"CH"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00054","properties":[{"key":"EntryName","value":"EFh"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00243","properties":[{"key":"EntryName","value":"GAS2"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00150","properties":[{"key":"EntryName","value":"SPEC"},{"key":"MatchStatus","value":"30"}]},{"database":"SUPFAM","id":"SSF47576","properties":[{"key":"EntryName","value":"Calponin-homology domain, CH-domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF47473","properties":[{"key":"EntryName","value":"EF-hand"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF143575","properties":[{"key":"EntryName","value":"GAS2 domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF46966","properties":[{"key":"EntryName","value":"Spectrin repeat"},{"key":"MatchStatus","value":"28"}]},{"database":"PROSITE","id":"PS00019","properties":[{"key":"EntryName","value":"ACTININ_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00020","properties":[{"key":"EntryName","value":"ACTININ_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50021","properties":[{"key":"EntryName","value":"CH"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS00018","properties":[{"key":"EntryName","value":"EF_HAND_1"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS50222","properties":[{"key":"EntryName","value":"EF_HAND_2"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS51460","properties":[{"key":"EntryName","value":"GAR"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50002","properties":[{"key":"EntryName","value":"SH3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAGYLSPAAYLYVEEQEYLQAYEDVLERYKDERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPREKGRMRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGESEDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLANLEHAFYVAEKIGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPEGGEGIGANDVEVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKETEIPPKETEKSKIKRLYKLLEIWIEFGRIKLLQGYHPNDIEKEWGKLIIAMLEREKALRPEVERLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISGITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPSGLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAALHPNKDAYKPITDADKIEDEVTRQVAKCKCAKRFQVEQIGDNKYRFFLGNQFGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCRAKGRTNMELREKFILADGASQGMAAFRPRGRRSRPSSRGASPNRSTSVSSQAAQAASPQVPATTTPKILHPLTRNYGKPWLTNSKMSTPCKAAECSDFPVPSAEGTPIQGSKLRLPGYLSGKGFHSGEDSGLITTAAARVRTQFADSKKTPSRPGSRAGSKAGSRASSRRGSDASDFDISEIQSVCSDVETVPQTHRPTPRAGSRPSTAKPSKIPTPQRKSPASKLDKSSKR","length":5497,"molWeight":629787,"crc64":"EBB46088AF623DED","md5":"AD35BF29D8A1D44FB0158120A2BC99C3"},"extraAttributes":{"countByCommentType":{"FUNCTION":3,"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Domain":6,"Region":2,"Coiled coil":16,"Compositional bias":3},"uniParcId":"UPI00001C1576"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q5T0V7","uniProtkbId":"Q5T0V7_HUMAN","entryAudit":{"firstPublicDate":"2004-12-21","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2023-05-03","entryVersion":150,"sequenceVersion":2},"annotationScore":4.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000393082.3"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00072808"}],"value":"Dystonin"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00077378"}],"value":"Bullous pemphigoid antigen 1"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00075126"}],"value":"Dystonia musculorum protein"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00077918"}],"value":"Hemidesmosomal plaque protein"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000393082.3"}],"value":"DST"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00054620"}],"value":"Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Mediates docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport through its interaction with TMEM108 and DCTN1"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00055817"}],"value":"Plays a structural role in the assembly of hemidesmosomes of epithelial cells; anchors keratin-containing intermediate filaments to the inner plaque of hemidesmosomes. Required for the regulation of keratinocyte polarity and motility; mediates integrin ITGB4 regulation of RAC1 activity"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00057123"}],"value":"Required for bundling actin filaments around the nucleus"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00060371"}],"value":"Cell junction, hemidesmosome","id":"SL-0137"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004193"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004193"}],"value":"Lipid-anchor","id":"SL-9901"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004489"}],"value":"Cell projection, axon","id":"SL-0279"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004544"}],"value":"Cytoplasm, cell cortex","id":"SL-0138"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004529"}],"value":"Cytoplasm, cytoskeleton, stress fiber","id":"SL-0501"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00060430"}],"value":"Cytoplasm, myofibril, sarcomere, H zone","id":"SL-0477"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004216"}],"value":"Cytoplasm, myofibril, sarcomere, Z line","id":"SL-0314"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004389"}],"value":"Endoplasmic reticulum membrane","id":"SL-0097"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004389"}],"value":"Single-pass membrane protein","id":"SL-9904"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004259"}],"value":"Nucleus envelope","id":"SL-0178"}}]}],"features":[{"type":"Domain","location":{"start":{"value":213,"modifier":"EXACT"},"end":{"value":316,"modifier":"EXACT"}},"description":"Calponin-homology (CH)","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50021"}]},{"type":"Domain","location":{"start":{"value":329,"modifier":"EXACT"},"end":{"value":433,"modifier":"EXACT"}},"description":"Calponin-homology (CH)","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50021"}]},{"type":"Domain","location":{"start":{"value":1065,"modifier":"EXACT"},"end":{"value":1122,"modifier":"EXACT"}},"description":"SH3","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50002"}]},{"type":"Domain","location":{"start":{"value":5180,"modifier":"EXACT"},"end":{"value":5215,"modifier":"EXACT"}},"description":"EF-hand","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50222"}]},{"type":"Domain","location":{"start":{"value":5216,"modifier":"EXACT"},"end":{"value":5251,"modifier":"EXACT"}},"description":"EF-hand","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50222"}]},{"type":"Domain","location":{"start":{"value":5256,"modifier":"EXACT"},"end":{"value":5328,"modifier":"EXACT"}},"description":"GAR","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51460"}]},{"type":"Region","location":{"start":{"value":100,"modifier":"EXACT"},"end":{"value":119,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":128,"modifier":"EXACT"},"end":{"value":192,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":5352,"modifier":"EXACT"},"end":{"value":5401,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":5471,"modifier":"EXACT"},"end":{"value":5560,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":912,"modifier":"EXACT"},"end":{"value":946,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":1386,"modifier":"EXACT"},"end":{"value":1420,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":1596,"modifier":"EXACT"},"end":{"value":1626,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":1682,"modifier":"EXACT"},"end":{"value":1709,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":1815,"modifier":"EXACT"},"end":{"value":1849,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":2031,"modifier":"EXACT"},"end":{"value":2058,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":2438,"modifier":"EXACT"},"end":{"value":2465,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":2650,"modifier":"EXACT"},"end":{"value":2677,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":2864,"modifier":"EXACT"},"end":{"value":2925,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":3149,"modifier":"EXACT"},"end":{"value":3223,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":3296,"modifier":"EXACT"},"end":{"value":3378,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":4177,"modifier":"EXACT"},"end":{"value":4204,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":4283,"modifier":"EXACT"},"end":{"value":4327,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":4429,"modifier":"EXACT"},"end":{"value":4467,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":4938,"modifier":"EXACT"},"end":{"value":4968,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Compositional bias","location":{"start":{"value":100,"modifier":"EXACT"},"end":{"value":112,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":138,"modifier":"EXACT"},"end":{"value":148,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":5364,"modifier":"EXACT"},"end":{"value":5394,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":5480,"modifier":"EXACT"},"end":{"value":5494,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":5509,"modifier":"EXACT"},"end":{"value":5525,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023203"}],"id":"KW-0009","category":"Molecular function","name":"Actin-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022837"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10142"}],"id":"KW-0106","category":"Ligand","name":"Calcium"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022889"}],"id":"KW-0130","category":"Biological process","name":"Cell adhesion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022949"}],"id":"KW-0965","category":"Cellular component","name":"Cell junction"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023273"}],"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023054"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00792"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023212"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00792"}],"id":"KW-0206","category":"Cellular component","name":"Cytoskeleton"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022824"}],"id":"KW-0256","category":"Cellular component","name":"Endoplasmic reticulum"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022754"}],"id":"KW-0403","category":"Cellular component","name":"Intermediate filament"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022499"}],"id":"KW-1017","category":"PTM","name":"Isopeptide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023288"}],"id":"KW-0449","category":"PTM","name":"Lipoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10142"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022701"}],"id":"KW-0493","category":"Cellular component","name":"Microtubule"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023179"}],"id":"KW-0514","category":"Molecular function","name":"Muscle protein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023139"}],"id":"KW-0564","category":"PTM","name":"Palmitate"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"Q5T0V7"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"Q5T0V7"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022443"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00192"}],"id":"KW-0728","category":"Domain","name":"SH3 domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022843"}],"id":"KW-0832","category":"PTM","name":"Ubl conjugation"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000393082.3"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"14574404","citationType":"journal article","authors":["Mungall A.J.","Palmer S.A.","Sims S.K.","Edwards C.A.","Ashurst J.L.","Wilming L.","Jones M.C.","Horton R.","Hunt S.E.","Scott C.E.","Gilbert J.G.","Clamp M.E.","Bethel G.","Milne S.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Andrews T.D.","Ashwell R.I.","Babbage A.K.","Bagguley C.L.","Bailey J.","Banerjee R.","Barker D.J.","Barlow K.F.","Bates K.","Beare D.M.","Beasley H.","Beasley O.","Bird C.P.","Blakey S.","Bray-Allen S.","Brook J.","Brown A.J.","Brown J.Y.","Burford D.C.","Burrill W.","Burton J.","Carder C.","Carter N.P.","Chapman J.C.","Clark S.Y.","Clark G.","Clee C.M.","Clegg S.","Cobley V.","Collier R.E.","Collins J.E.","Colman L.K.","Corby N.R.","Coville G.J.","Culley K.M.","Dhami P.","Davies J.","Dunn M.","Earthrowl M.E.","Ellington A.E.","Evans K.A.","Faulkner L.","Francis M.D.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Ghori M.J.","Gilby L.M.","Gillson C.J.","Glithero R.J.","Grafham D.V.","Grant M.","Gribble S.","Griffiths C.","Griffiths M.","Hall R.","Halls K.S.","Hammond S.","Harley J.L.","Hart E.A.","Heath P.D.","Heathcott R.","Holmes S.J.","Howden P.J.","Howe K.L.","Howell G.R.","Huckle E.","Humphray S.J.","Humphries M.D.","Hunt A.R.","Johnson C.M.","Joy A.A.","Kay M.","Keenan S.J.","Kimberley A.M.","King A.","Laird G.K.","Langford C.","Lawlor S.","Leongamornlert D.A.","Leversha M.","Lloyd C.R.","Lloyd D.M.","Loveland J.E.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","Maslen G.L.","Matthews L.","McCann O.T.","McLaren S.J.","McLay K.","McMurray A.","Moore M.J.","Mullikin J.C.","Niblett D.","Nickerson T.","Novik K.L.","Oliver K.","Overton-Larty E.K.","Parker A.","Patel R.","Pearce A.V.","Peck A.I.","Phillimore B.","Phillips S.","Plumb R.W.","Porter K.M.","Ramsey Y.","Ranby S.A.","Rice C.M.","Ross M.T.","Searle S.M.","Sehra H.K.","Sheridan E.","Skuce C.D.","Smith S.","Smith M.","Spraggon L.","Squares S.L.","Steward C.A.","Sycamore N.","Tamlyn-Hall G.","Tester J.","Theaker A.J.","Thomas D.W.","Thorpe A.","Tracey A.","Tromans A.","Tubby B.","Wall M.","Wallis J.M.","West A.P.","White S.S.","Whitehead S.L.","Whittaker H.","Wild A.","Willey D.J.","Wilmer T.E.","Wood J.M.","Wray P.W.","Wyatt J.C.","Young L.","Younger R.M.","Bentley D.R.","Coulson A.","Durbin R.","Hubbard T.","Sulston J.E.","Dunham I.","Rogers J.","Beck S."],"citationCrossReferences":[{"database":"PubMed","id":"14574404"},{"database":"DOI","id":"10.1038/nature02055"}],"title":"The DNA sequence and analysis of human chromosome 6.","publicationDate":"2003","journal":"Nature","firstPage":"805","lastPage":"811","volume":"425"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000393082.3"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000393082.3"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Burckstummer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"21269460"}]},{"referenceNumber":5,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"23186163"}]},{"referenceNumber":6,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"24275569"}]},{"referenceNumber":7,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000393082.3"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL096710","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL137008","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL512422","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL512448","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL590005","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL590037","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"KF458172","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"Q5T0V7","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q5T0V7","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q5T0V7","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"64208","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"31066","properties":[{"key":"antibodies","value":"185 antibodies from 24 providers"}]},{"database":"Ensembl","id":"ENST00000449297.7","properties":[{"key":"ProteinId","value":"ENSP00000393082.3"},{"key":"GeneId","value":"ENSG00000151914.22"}]},{"database":"UCSC","id":"uc063pff.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:1090","properties":[{"key":"GeneName","value":"DST"}]},{"database":"OpenTargets","id":"ENSG00000151914","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000151914","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000155008","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_399871_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"9479997at2759","properties":[{"key":"Description","value":"-"}]},{"database":"CD-CODE","id":"DEE660B4","properties":[{"key":"EntryName","value":"Stress granule"}]},{"database":"ChiTaRS","id":"DST","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 6"}]},{"database":"Bgee","id":"ENSG00000151914","properties":[{"key":"ExpressionPatterns","value":"Expressed in corpus callosum and 207 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q5T0V7","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0030424","properties":[{"key":"GoTerm","value":"C:axon"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005938","properties":[{"key":"GoTerm","value":"C:cell cortex"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0031252","properties":[{"key":"GoTerm","value":"C:cell leading edge"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0005789","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0031673","properties":[{"key":"GoTerm","value":"C:H zone"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0030056","properties":[{"key":"GoTerm","value":"C:hemidesmosome"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0045111","properties":[{"key":"GoTerm","value":"C:intermediate filament cytoskeleton"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0015630","properties":[{"key":"GoTerm","value":"C:microtubule cytoskeleton"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0005635","properties":[{"key":"GoTerm","value":"C:nuclear envelope"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0099513","properties":[{"key":"GoTerm","value":"C:polymeric cytoskeletal fiber"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0001725","properties":[{"key":"GoTerm","value":"C:stress fiber"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0030018","properties":[{"key":"GoTerm","value":"C:Z disc"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005509","properties":[{"key":"GoTerm","value":"F:calcium ion binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0008017","properties":[{"key":"GoTerm","value":"F:microtubule binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0042803","properties":[{"key":"GoTerm","value":"F:protein homodimerization activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0045104","properties":[{"key":"GoTerm","value":"P:intermediate filament cytoskeleton organization"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0000226","properties":[{"key":"GoTerm","value":"P:microtubule cytoskeleton organization"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd21236","properties":[{"key":"EntryName","value":"CH_DYST_rpt1"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd21239","properties":[{"key":"EntryName","value":"CH_DYST_rpt2"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd00051","properties":[{"key":"EntryName","value":"EFh"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd00176","properties":[{"key":"EntryName","value":"SPEC"},{"key":"MatchStatus","value":"15"}]},{"database":"FunFam","id":"1.20.58.60:FF:000144","properties":[{"key":"EntryName","value":"Dystonin"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000185","properties":[{"key":"EntryName","value":"Dystonin"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000009","properties":[{"key":"EntryName","value":"dystonin isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000074","properties":[{"key":"EntryName","value":"dystonin isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000077","properties":[{"key":"EntryName","value":"dystonin isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000093","properties":[{"key":"EntryName","value":"dystonin isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000111","properties":[{"key":"EntryName","value":"dystonin isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000114","properties":[{"key":"EntryName","value":"dystonin isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000121","properties":[{"key":"EntryName","value":"dystonin isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000052","properties":[{"key":"EntryName","value":"dystonin isoform X2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000060","properties":[{"key":"EntryName","value":"dystonin isoform X2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000069","properties":[{"key":"EntryName","value":"dystonin isoform X2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000085","properties":[{"key":"EntryName","value":"dystonin isoform X2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000094","properties":[{"key":"EntryName","value":"dystonin isoform X2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000098","properties":[{"key":"EntryName","value":"dystonin isoform X3"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.238.10:FF:000013","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.418.10:FF:000002","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.418.10:FF:000017","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000001","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"3"}]},{"database":"FunFam","id":"1.20.58.60:FF:000008","properties":[{"key":"EntryName","value":"microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000012","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000014","properties":[{"key":"EntryName","value":"microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000016","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000021","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000022","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000025","properties":[{"key":"EntryName","value":"microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000027","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000031","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.30.30.40:FF:000011","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.920.20:FF:000001","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000010","properties":[{"key":"EntryName","value":"plectin isoform X2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.58.1060","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.58.60","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"29"}]},{"database":"Gene3D","id":"1.10.418.10","properties":[{"key":"EntryName","value":"Calponin-like domain"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"1.10.238.10","properties":[{"key":"EntryName","value":"EF-hand"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.920.20","properties":[{"key":"EntryName","value":"Gas2-like domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.30.30.40","properties":[{"key":"EntryName","value":"SH3 Domains"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001589","properties":[{"key":"EntryName","value":"Actinin_actin-bd_CS"}]},{"database":"InterPro","id":"IPR001715","properties":[{"key":"EntryName","value":"CH_dom"}]},{"database":"InterPro","id":"IPR036872","properties":[{"key":"EntryName","value":"CH_dom_sf"}]},{"database":"InterPro","id":"IPR041615","properties":[{"key":"EntryName","value":"Desmoplakin_SH3"}]},{"database":"InterPro","id":"IPR041573","properties":[{"key":"EntryName","value":"Desmoplakin_Spectrin-like"}]},{"database":"InterPro","id":"IPR011992","properties":[{"key":"EntryName","value":"EF-hand-dom_pair"}]},{"database":"InterPro","id":"IPR018247","properties":[{"key":"EntryName","value":"EF_Hand_1_Ca_BS"}]},{"database":"InterPro","id":"IPR002048","properties":[{"key":"EntryName","value":"EF_hand_dom"}]},{"database":"InterPro","id":"IPR003108","properties":[{"key":"EntryName","value":"GAR_dom"}]},{"database":"InterPro","id":"IPR036534","properties":[{"key":"EntryName","value":"GAR_dom_sf"}]},{"database":"InterPro","id":"IPR049538","properties":[{"key":"EntryName","value":"PCN-like_spectrin-like_rpt"}]},{"database":"InterPro","id":"IPR043197","properties":[{"key":"EntryName","value":"Plakin"}]},{"database":"InterPro","id":"IPR001452","properties":[{"key":"EntryName","value":"SH3_domain"}]},{"database":"InterPro","id":"IPR018159","properties":[{"key":"EntryName","value":"Spectrin/alpha-actinin"}]},{"database":"InterPro","id":"IPR002017","properties":[{"key":"EntryName","value":"Spectrin_repeat"}]},{"database":"PANTHER","id":"PTHR23169:SF24","properties":[{"key":"EntryName","value":"DYSTONIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR23169","properties":[{"key":"EntryName","value":"ENVOPLAKIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00307","properties":[{"key":"EntryName","value":"CH"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF13499","properties":[{"key":"EntryName","value":"EF-hand_7"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02187","properties":[{"key":"EntryName","value":"GAS2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF17902","properties":[{"key":"EntryName","value":"SH3_10"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00435","properties":[{"key":"EntryName","value":"Spectrin"},{"key":"MatchStatus","value":"21"}]},{"database":"Pfam","id":"PF18373","properties":[{"key":"EntryName","value":"Spectrin_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF21019","properties":[{"key":"EntryName","value":"Spectrin_3"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF21020","properties":[{"key":"EntryName","value":"Spectrin_4"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF27015","properties":[{"key":"EntryName","value":"SR_desmoplakin_3"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF21097","properties":[{"key":"EntryName","value":"SR_plectin_7"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00033","properties":[{"key":"EntryName","value":"CH"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00054","properties":[{"key":"EntryName","value":"EFh"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00243","properties":[{"key":"EntryName","value":"GAS2"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00150","properties":[{"key":"EntryName","value":"SPEC"},{"key":"MatchStatus","value":"29"}]},{"database":"SUPFAM","id":"SSF47576","properties":[{"key":"EntryName","value":"Calponin-homology domain, CH-domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF47473","properties":[{"key":"EntryName","value":"EF-hand"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF143575","properties":[{"key":"EntryName","value":"GAS2 domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF46966","properties":[{"key":"EntryName","value":"Spectrin repeat"},{"key":"MatchStatus","value":"27"}]},{"database":"PROSITE","id":"PS00019","properties":[{"key":"EntryName","value":"ACTININ_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00020","properties":[{"key":"EntryName","value":"ACTININ_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50021","properties":[{"key":"EntryName","value":"CH"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS00018","properties":[{"key":"EntryName","value":"EF_HAND_1"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS50222","properties":[{"key":"EntryName","value":"EF_HAND_2"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS51460","properties":[{"key":"EntryName","value":"GAR"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50002","properties":[{"key":"EntryName","value":"SH3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MIAAAFLVLLRPYSIQCALFLLLLLLGTIATIVFFCCWHRKLQKGRHPMKSVFSGRSRSRDAVLRSHHFRSEGFRASPRHLRRRVAAAAAARLEEVKPVVEVHHQSEQETSVRKRRIKKSSRVQPEFYHSVQGASIRRPSSGNASYRCSMSSSADFSDEDDFSQKSGSASPAPGDTLPWNLPKHERSKRKIQGGSVLDPAERAVLRIADERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPREKGRMRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGESEDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLANLEHAFYVAEKIGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPEGGEGIGANDVEVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKETEIPPKETEKSKIKRLYKLLEIWIEFGRIKLLQGYHPNDIEKEWGKLIIAMLEREKALRPEVERLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISGITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPSGLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAALHPNKDAYKPITDADKIEDEVTRQVAKCKCAKRFQVEQIGDNKYRFGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCRAKGRTNMELREKFILADGASQGMAAFRPRGRRSRPSSRGASPNRSTSVSSQAAQAASPQVPATTTPKILHPLTRNYGKPWLTNSKMSTPCKAAECSDFPVPSAEGTPIQGSKLRLPGYLSGKGFHSGEDSGLITTAAARVRTQFADSKKTPSRPGSRAGSKAGSRASSRRGSDASDFDISEIQSVCSDVETVPQTHRPTPRAGSRPSTAKPSKIPTPQRKSPASKLDKSSKR","length":5560,"molWeight":636144,"crc64":"CF9B061A6C53233B","md5":"304C5E6D8A536FA969D7DA90DA7F4EBB"},"extraAttributes":{"countByCommentType":{"FUNCTION":3,"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Domain":6,"Region":4,"Coiled coil":15,"Compositional bias":5},"uniParcId":"UPI0021ECD4AC"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A7P0T890","uniProtkbId":"A0A7P0T890_HUMAN","entryAudit":{"firstPublicDate":"2021-06-02","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2021-06-02","entryVersion":24,"sequenceVersion":1},"annotationScore":4.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000505098.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00072808"}],"value":"Dystonin"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00077378"}],"value":"Bullous pemphigoid antigen 1"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00075126"}],"value":"Dystonia musculorum protein"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00077918"}],"value":"Hemidesmosomal plaque protein"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000505098.1"}],"value":"DST"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00054620"}],"value":"Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Mediates docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport through its interaction with TMEM108 and DCTN1"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00055817"}],"value":"Plays a structural role in the assembly of hemidesmosomes of epithelial cells; anchors keratin-containing intermediate filaments to the inner plaque of hemidesmosomes. Required for the regulation of keratinocyte polarity and motility; mediates integrin ITGB4 regulation of RAC1 activity"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00057123"}],"value":"Required for bundling actin filaments around the nucleus"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004193"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004193"}],"value":"Lipid-anchor","id":"SL-9901"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004489"}],"value":"Cell projection, axon","id":"SL-0279"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004544"}],"value":"Cytoplasm, cell cortex","id":"SL-0138"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004529"}],"value":"Cytoplasm, cytoskeleton, stress fiber","id":"SL-0501"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00060430"}],"value":"Cytoplasm, myofibril, sarcomere, H zone","id":"SL-0477"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004216"}],"value":"Cytoplasm, myofibril, sarcomere, Z line","id":"SL-0314"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004389"}],"value":"Endoplasmic reticulum membrane","id":"SL-0097"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004389"}],"value":"Single-pass membrane protein","id":"SL-9904"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004259"}],"value":"Nucleus envelope","id":"SL-0178"}}]}],"features":[{"type":"Domain","location":{"start":{"value":213,"modifier":"EXACT"},"end":{"value":349,"modifier":"EXACT"}},"description":"Calponin-homology (CH)","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50021"}]},{"type":"Domain","location":{"start":{"value":362,"modifier":"EXACT"},"end":{"value":466,"modifier":"EXACT"}},"description":"Calponin-homology (CH)","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50021"}]},{"type":"Domain","location":{"start":{"value":1098,"modifier":"EXACT"},"end":{"value":1155,"modifier":"EXACT"}},"description":"SH3","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50002"}]},{"type":"Domain","location":{"start":{"value":7408,"modifier":"EXACT"},"end":{"value":7443,"modifier":"EXACT"}},"description":"EF-hand","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50222"}]},{"type":"Domain","location":{"start":{"value":7444,"modifier":"EXACT"},"end":{"value":7479,"modifier":"EXACT"}},"description":"EF-hand","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50222"}]},{"type":"Domain","location":{"start":{"value":7484,"modifier":"EXACT"},"end":{"value":7562,"modifier":"EXACT"}},"description":"GAR","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51460"}]},{"type":"Region","location":{"start":{"value":100,"modifier":"EXACT"},"end":{"value":119,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":128,"modifier":"EXACT"},"end":{"value":192,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":2528,"modifier":"EXACT"},"end":{"value":2557,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":2594,"modifier":"EXACT"},"end":{"value":2652,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":2796,"modifier":"EXACT"},"end":{"value":2827,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":3401,"modifier":"EXACT"},"end":{"value":3432,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":7570,"modifier":"EXACT"},"end":{"value":7590,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":7610,"modifier":"EXACT"},"end":{"value":7659,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":7729,"modifier":"EXACT"},"end":{"value":7818,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":945,"modifier":"EXACT"},"end":{"value":979,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":1419,"modifier":"EXACT"},"end":{"value":1453,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":1629,"modifier":"EXACT"},"end":{"value":1659,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":1715,"modifier":"EXACT"},"end":{"value":1742,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":3934,"modifier":"EXACT"},"end":{"value":3968,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":4150,"modifier":"EXACT"},"end":{"value":4177,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":4557,"modifier":"EXACT"},"end":{"value":4584,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":4769,"modifier":"EXACT"},"end":{"value":4796,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":4983,"modifier":"EXACT"},"end":{"value":5044,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":5268,"modifier":"EXACT"},"end":{"value":5342,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":5415,"modifier":"EXACT"},"end":{"value":5497,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":6405,"modifier":"EXACT"},"end":{"value":6432,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":6511,"modifier":"EXACT"},"end":{"value":6555,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":6657,"modifier":"EXACT"},"end":{"value":6695,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":7166,"modifier":"EXACT"},"end":{"value":7196,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Compositional bias","location":{"start":{"value":100,"modifier":"EXACT"},"end":{"value":112,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":138,"modifier":"EXACT"},"end":{"value":148,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":2547,"modifier":"EXACT"},"end":{"value":2556,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":2596,"modifier":"EXACT"},"end":{"value":2605,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":2606,"modifier":"EXACT"},"end":{"value":2623,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":2641,"modifier":"EXACT"},"end":{"value":2650,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":2802,"modifier":"EXACT"},"end":{"value":2816,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":3403,"modifier":"EXACT"},"end":{"value":3420,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":7573,"modifier":"EXACT"},"end":{"value":7585,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":7622,"modifier":"EXACT"},"end":{"value":7652,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":7738,"modifier":"EXACT"},"end":{"value":7752,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":7767,"modifier":"EXACT"},"end":{"value":7783,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023203"}],"id":"KW-0009","category":"Molecular function","name":"Actin-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022837"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10142"}],"id":"KW-0106","category":"Ligand","name":"Calcium"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022889"}],"id":"KW-0130","category":"Biological process","name":"Cell adhesion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023273"}],"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00792"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023212"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00792"}],"id":"KW-0206","category":"Cellular component","name":"Cytoskeleton"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022824"}],"id":"KW-0256","category":"Cellular component","name":"Endoplasmic reticulum"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022754"}],"id":"KW-0403","category":"Cellular component","name":"Intermediate filament"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022499"}],"id":"KW-1017","category":"PTM","name":"Isopeptide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023288"}],"id":"KW-0449","category":"PTM","name":"Lipoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10142"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022701"}],"id":"KW-0493","category":"Cellular component","name":"Microtubule"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023179"}],"id":"KW-0514","category":"Molecular function","name":"Muscle protein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023139"}],"id":"KW-0564","category":"PTM","name":"Palmitate"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0A7P0T890"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0A7P0T890"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022443"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00192"}],"id":"KW-0728","category":"Domain","name":"SH3 domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022843"}],"id":"KW-0832","category":"PTM","name":"Ubl conjugation"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000505098.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"14574404","citationType":"journal article","authors":["Mungall A.J.","Palmer S.A.","Sims S.K.","Edwards C.A.","Ashurst J.L.","Wilming L.","Jones M.C.","Horton R.","Hunt S.E.","Scott C.E.","Gilbert J.G.","Clamp M.E.","Bethel G.","Milne S.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Andrews T.D.","Ashwell R.I.","Babbage A.K.","Bagguley C.L.","Bailey J.","Banerjee R.","Barker D.J.","Barlow K.F.","Bates K.","Beare D.M.","Beasley H.","Beasley O.","Bird C.P.","Blakey S.","Bray-Allen S.","Brook J.","Brown A.J.","Brown J.Y.","Burford D.C.","Burrill W.","Burton J.","Carder C.","Carter N.P.","Chapman J.C.","Clark S.Y.","Clark G.","Clee C.M.","Clegg S.","Cobley V.","Collier R.E.","Collins J.E.","Colman L.K.","Corby N.R.","Coville G.J.","Culley K.M.","Dhami P.","Davies J.","Dunn M.","Earthrowl M.E.","Ellington A.E.","Evans K.A.","Faulkner L.","Francis M.D.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Ghori M.J.","Gilby L.M.","Gillson C.J.","Glithero R.J.","Grafham D.V.","Grant M.","Gribble S.","Griffiths C.","Griffiths M.","Hall R.","Halls K.S.","Hammond S.","Harley J.L.","Hart E.A.","Heath P.D.","Heathcott R.","Holmes S.J.","Howden P.J.","Howe K.L.","Howell G.R.","Huckle E.","Humphray S.J.","Humphries M.D.","Hunt A.R.","Johnson C.M.","Joy A.A.","Kay M.","Keenan S.J.","Kimberley A.M.","King A.","Laird G.K.","Langford C.","Lawlor S.","Leongamornlert D.A.","Leversha M.","Lloyd C.R.","Lloyd D.M.","Loveland J.E.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","Maslen G.L.","Matthews L.","McCann O.T.","McLaren S.J.","McLay K.","McMurray A.","Moore M.J.","Mullikin J.C.","Niblett D.","Nickerson T.","Novik K.L.","Oliver K.","Overton-Larty E.K.","Parker A.","Patel R.","Pearce A.V.","Peck A.I.","Phillimore B.","Phillips S.","Plumb R.W.","Porter K.M.","Ramsey Y.","Ranby S.A.","Rice C.M.","Ross M.T.","Searle S.M.","Sehra H.K.","Sheridan E.","Skuce C.D.","Smith S.","Smith M.","Spraggon L.","Squares S.L.","Steward C.A.","Sycamore N.","Tamlyn-Hall G.","Tester J.","Theaker A.J.","Thomas D.W.","Thorpe A.","Tracey A.","Tromans A.","Tubby B.","Wall M.","Wallis J.M.","West A.P.","White S.S.","Whitehead S.L.","Whittaker H.","Wild A.","Willey D.J.","Wilmer T.E.","Wood J.M.","Wray P.W.","Wyatt J.C.","Young L.","Younger R.M.","Bentley D.R.","Coulson A.","Durbin R.","Hubbard T.","Sulston J.E.","Dunham I.","Rogers J.","Beck S."],"citationCrossReferences":[{"database":"PubMed","id":"14574404"},{"database":"DOI","id":"10.1038/nature02055"}],"title":"The DNA sequence and analysis of human chromosome 6.","publicationDate":"2003","journal":"Nature","firstPage":"805","lastPage":"811","volume":"425"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000505098.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000505098.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000505098.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL096710","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL137008","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL512422","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL512448","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL590005","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL590037","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"KF458172","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"NP_001361665.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001374736.1"}]},{"database":"SMR","id":"A0A7P0T890","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000680361.1","properties":[{"key":"ProteinId","value":"ENSP00000505098.1"},{"key":"GeneId","value":"ENSG00000151914.22"}]},{"database":"GeneID","id":"667","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000680361.1","properties":[{"key":"ProteinId","value":"ENSP00000505098.1"},{"key":"RefSeqNucleotideId","value":"NM_001374736.1"},{"key":"RefSeqProteinId","value":"NP_001361665.1"}]},{"database":"CTD","id":"667","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:1090","properties":[{"key":"GeneName","value":"DST"}]},{"database":"OpenTargets","id":"ENSG00000151914","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000155008","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"9479997at2759","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 6"}]},{"database":"Bgee","id":"ENSG00000151914","properties":[{"key":"ExpressionPatterns","value":"Expressed in corpus callosum and 207 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"A0A7P0T890","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0030424","properties":[{"key":"GoTerm","value":"C:axon"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005938","properties":[{"key":"GoTerm","value":"C:cell cortex"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0031252","properties":[{"key":"GoTerm","value":"C:cell leading edge"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0005789","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0031673","properties":[{"key":"GoTerm","value":"C:H zone"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0030056","properties":[{"key":"GoTerm","value":"C:hemidesmosome"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0045111","properties":[{"key":"GoTerm","value":"C:intermediate filament cytoskeleton"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0015630","properties":[{"key":"GoTerm","value":"C:microtubule cytoskeleton"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0005635","properties":[{"key":"GoTerm","value":"C:nuclear envelope"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0099513","properties":[{"key":"GoTerm","value":"C:polymeric cytoskeletal fiber"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0001725","properties":[{"key":"GoTerm","value":"C:stress fiber"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0030018","properties":[{"key":"GoTerm","value":"C:Z disc"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005509","properties":[{"key":"GoTerm","value":"F:calcium ion binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0008017","properties":[{"key":"GoTerm","value":"F:microtubule binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0042803","properties":[{"key":"GoTerm","value":"F:protein homodimerization activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0045104","properties":[{"key":"GoTerm","value":"P:intermediate filament cytoskeleton organization"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0000226","properties":[{"key":"GoTerm","value":"P:microtubule cytoskeleton organization"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd21239","properties":[{"key":"EntryName","value":"CH_DYST_rpt2"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd00051","properties":[{"key":"EntryName","value":"EFh"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd00176","properties":[{"key":"EntryName","value":"SPEC"},{"key":"MatchStatus","value":"17"}]},{"database":"FunFam","id":"1.20.58.60:FF:000144","properties":[{"key":"EntryName","value":"Dystonin"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000185","properties":[{"key":"EntryName","value":"Dystonin"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.1290.10:FF:000022","properties":[{"key":"EntryName","value":"Dystonin"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000009","properties":[{"key":"EntryName","value":"dystonin isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000074","properties":[{"key":"EntryName","value":"dystonin isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000077","properties":[{"key":"EntryName","value":"dystonin isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000093","properties":[{"key":"EntryName","value":"dystonin isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000111","properties":[{"key":"EntryName","value":"dystonin isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000114","properties":[{"key":"EntryName","value":"dystonin isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000121","properties":[{"key":"EntryName","value":"dystonin isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.920.20:FF:000002","properties":[{"key":"EntryName","value":"dystonin isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000052","properties":[{"key":"EntryName","value":"dystonin isoform X2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000060","properties":[{"key":"EntryName","value":"dystonin isoform X2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000069","properties":[{"key":"EntryName","value":"dystonin isoform X2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000085","properties":[{"key":"EntryName","value":"dystonin isoform X2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000094","properties":[{"key":"EntryName","value":"dystonin isoform X2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000098","properties":[{"key":"EntryName","value":"dystonin isoform X3"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.1290.10:FF:000013","properties":[{"key":"EntryName","value":"dystonin isoform X7"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.1290.10:FF:000015","properties":[{"key":"EntryName","value":"dystonin isoform X7"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.238.10:FF:000013","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.418.10:FF:000002","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000001","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"3"}]},{"database":"FunFam","id":"1.20.58.60:FF:000008","properties":[{"key":"EntryName","value":"microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"2"}]},{"database":"FunFam","id":"1.20.58.60:FF:000012","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000014","properties":[{"key":"EntryName","value":"microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000016","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000021","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000022","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000025","properties":[{"key":"EntryName","value":"microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000027","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000031","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.30.30.40:FF:000011","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000010","properties":[{"key":"EntryName","value":"plectin isoform X2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.58.1060","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.58.60","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"31"}]},{"database":"Gene3D","id":"1.10.418.10","properties":[{"key":"EntryName","value":"Calponin-like domain"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"1.10.238.10","properties":[{"key":"EntryName","value":"EF-hand"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.920.20","properties":[{"key":"EntryName","value":"Gas2-like domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.90.1290.10","properties":[{"key":"EntryName","value":"Plakin repeat"},{"key":"MatchStatus","value":"3"}]},{"database":"Gene3D","id":"2.30.30.40","properties":[{"key":"EntryName","value":"SH3 Domains"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001589","properties":[{"key":"EntryName","value":"Actinin_actin-bd_CS"}]},{"database":"InterPro","id":"IPR001715","properties":[{"key":"EntryName","value":"CH_dom"}]},{"database":"InterPro","id":"IPR036872","properties":[{"key":"EntryName","value":"CH_dom_sf"}]},{"database":"InterPro","id":"IPR041615","properties":[{"key":"EntryName","value":"Desmoplakin_SH3"}]},{"database":"InterPro","id":"IPR041573","properties":[{"key":"EntryName","value":"Desmoplakin_Spectrin-like"}]},{"database":"InterPro","id":"IPR011992","properties":[{"key":"EntryName","value":"EF-hand-dom_pair"}]},{"database":"InterPro","id":"IPR018247","properties":[{"key":"EntryName","value":"EF_Hand_1_Ca_BS"}]},{"database":"InterPro","id":"IPR002048","properties":[{"key":"EntryName","value":"EF_hand_dom"}]},{"database":"InterPro","id":"IPR003108","properties":[{"key":"EntryName","value":"GAR_dom"}]},{"database":"InterPro","id":"IPR036534","properties":[{"key":"EntryName","value":"GAR_dom_sf"}]},{"database":"InterPro","id":"IPR049538","properties":[{"key":"EntryName","value":"PCN-like_spectrin-like_rpt"}]},{"database":"InterPro","id":"IPR043197","properties":[{"key":"EntryName","value":"Plakin"}]},{"database":"InterPro","id":"IPR035915","properties":[{"key":"EntryName","value":"Plakin_repeat_sf"}]},{"database":"InterPro","id":"IPR001101","properties":[{"key":"EntryName","value":"Plectin_repeat"}]},{"database":"InterPro","id":"IPR001452","properties":[{"key":"EntryName","value":"SH3_domain"}]},{"database":"InterPro","id":"IPR018159","properties":[{"key":"EntryName","value":"Spectrin/alpha-actinin"}]},{"database":"InterPro","id":"IPR002017","properties":[{"key":"EntryName","value":"Spectrin_repeat"}]},{"database":"PANTHER","id":"PTHR23169:SF24","properties":[{"key":"EntryName","value":"DYSTONIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR23169","properties":[{"key":"EntryName","value":"ENVOPLAKIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00307","properties":[{"key":"EntryName","value":"CH"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF13499","properties":[{"key":"EntryName","value":"EF-hand_7"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02187","properties":[{"key":"EntryName","value":"GAS2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00681","properties":[{"key":"EntryName","value":"Plectin"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF17902","properties":[{"key":"EntryName","value":"SH3_10"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00435","properties":[{"key":"EntryName","value":"Spectrin"},{"key":"MatchStatus","value":"20"}]},{"database":"Pfam","id":"PF18373","properties":[{"key":"EntryName","value":"Spectrin_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF21019","properties":[{"key":"EntryName","value":"Spectrin_3"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF21020","properties":[{"key":"EntryName","value":"Spectrin_4"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF27015","properties":[{"key":"EntryName","value":"SR_desmoplakin_3"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF21097","properties":[{"key":"EntryName","value":"SR_plectin_7"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00033","properties":[{"key":"EntryName","value":"CH"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00054","properties":[{"key":"EntryName","value":"EFh"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00243","properties":[{"key":"EntryName","value":"GAS2"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00250","properties":[{"key":"EntryName","value":"PLEC"},{"key":"MatchStatus","value":"8"}]},{"database":"SMART","id":"SM00150","properties":[{"key":"EntryName","value":"SPEC"},{"key":"MatchStatus","value":"32"}]},{"database":"SUPFAM","id":"SSF47576","properties":[{"key":"EntryName","value":"Calponin-homology domain, CH-domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF47473","properties":[{"key":"EntryName","value":"EF-hand"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF143575","properties":[{"key":"EntryName","value":"GAS2 domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF75399","properties":[{"key":"EntryName","value":"Plakin repeat"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF46966","properties":[{"key":"EntryName","value":"Spectrin repeat"},{"key":"MatchStatus","value":"29"}]},{"database":"PROSITE","id":"PS00019","properties":[{"key":"EntryName","value":"ACTININ_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00020","properties":[{"key":"EntryName","value":"ACTININ_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50021","properties":[{"key":"EntryName","value":"CH"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS00018","properties":[{"key":"EntryName","value":"EF_HAND_1"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS50222","properties":[{"key":"EntryName","value":"EF_HAND_2"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS51460","properties":[{"key":"EntryName","value":"GAR"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50002","properties":[{"key":"EntryName","value":"SH3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MIAAAFLVLLRPYSIQCALFLLLLLLGTIATIVFFCCWHRKLQKGRHPMKSVFSGRSRSRDAVLRSHHFRSEGFRASPRHLRRRVAAAAAARLEEVKPVVEVHHQSEQETSVRKRRIKKSSRVQPEFYHSVQGASIRRPSSGNASYRCSMSSSADFSDEDDFSQKSGSASPAPGDTLPWNLPKHERSKRKIQGGSVLDPAERAVLRIADERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPRERDFLKTLRLVSATEACEYEQHEDVEDEDKGPREKGRMRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGESEDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLANLEHAFYVAEKIGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPEGGEGIGANDVEVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKETEIPPKETEKSKIKRLYKLLEIWIEFGRIKLLQGYHPNDIEKEWGKLIIAMLEREKALRPEVERLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISGITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPSGLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKLDKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLKDAKSHGLIDEQILCQLKELSKAKEIISAASPTTIPVLDALAQSMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLKCGRNISILRAAHEGLIDRETMFRLLSAQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSILTYQVQTGGIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELITNELAYKILNGRQKIAALYIPESSQVIGLDAAKQLGIIDNNTASILKNITLPDKMPDLGDLEACKNARRWLSFCKFQPSTVHDYRQEEDVFDGEEPVTTQTSEETKKLFLSYLMINSYMDANTGQRLLLYDGDLDEAVGMLLEGCHAEFDGNTAIKECLDVLSSSGVFLNNASGREKDECTATPSSFNKCHCGEPEHEETPENRKCAIDEEFNEMRNTVINSEFSQSGKLASTISIDPKVNSSPSVCVPSLISYLTQTELADISMLRSDSENILTNYENQSRVETNERANECSHSKNIQNFPSDLIENPIMKSKMSKFCGVNETENEDNTNRDSPIFDYSPRLSALLSHDKLMHSQGSFNDTHTPESNGNKCEAPALSFSDKTMLSGQRIGEKFQDQFLGIAAINISLPGEQYGQKSLNMISSNPQVQYHNDKYISNTSGEDEKTHPGFQQMPEDKEDESEIEEYSCAVTPGGDTDNAIVSLTCATPLLDETISASDYETSLLNDQQNNTGTDTDSDDDFYDTPLFEDDDHDSLLLDGDDRDCLHPEDYDTLQEENDETASPADVFYDVSKENENSMVPQGAPVGSLSVKNKAHCLQDFLMDVEKDELDSGEKIHLNPVGSDKVNGQSLETGSERECTNILEGDESDSLTDYDIVGGKESFTASLKFDDSGSWRGRKEEYVTGQEFHSDTDHLDSMQSEESYGDYIYDSNDQDDDDDDGIDEEGGGIRDENGKPRCQNVAEDMDIQLCASILNENSDENENINTMILLDKMHSCSSLEKQQRVNVVQLASPSENNLVTEKSNLPEYTTEIAGKSKENLLNHEMVLKDVLPPIIKDTESEKTFGPASISHDNNNISSTSELGTDLANTKVKLIQGSELPELTDSVKGKDEYFKNMTPKVDSSLDHIICTEPDLIGKPAEESHLSLIASVTDKDPQGNGSDLIKGRDGKSDILIEDETSIQKMYLGEGEVLVEGLVEEENRHLKLLPGKNTRDSFKLINSQFPFPQITNNEELNQKGSLKKATVTLKDEPNNLQIIVSKSPVQFENLEEIFDTSVSKEISDDITSDITSWEGNTHFEESFTDGPEKELDLFTYLKHCAKNIKAKDVAKPNEDVPSHVLITAPPMKEHLQLGVNNTKEKSTSTQKDSPLNDMIQSNDLCSKESISGGGTEISQFTPESIEATLSILSRKHVEDVGKNDFLQSERCANGLGNDNSSNTLNTDYSFLEINNKKERIEQQLPKEQALSPRSQEKEVQIPELSQVFVEDVKDILKSRLKEGHMNPQEVEEPSACADTKILIQNLIKRITTSQLVNEASTVPSDSQMSDSSGVSPMTNSSELKPESRDDPFCIGNLKSELLLNILKQDQHSQKITGVFELMRELTHMEYDLEKRGITSKVLPLQLENIFYKLLADGYSEKIEHVGDFNQKACSTSEMMEEKPHILGDIKSKEGNYYSPNLETVKEIGLESSTVWASTLPRDEKLKDLCNDFPSHLECTSGSKEMASGDSSTEQFSSELQQCLQHTEKMHEYLTLLQDMKPPLDNQESLDNNLEALKNQLRQLETFELGLAPIAVILRKDMKLAEEFLKSLPSDFPRGHVEELSISHQSLKTAFSSLSNVSSERTKQIMLAIDSEMSKLAVSHEEFLHKLKSFSDWVSEKSKSVKDIEIVNVQDSEYVKKRLEFLKNVLKDLGHTKMQLETTAFDVQFFISEYAQDLSPNQSKQLLRLLNTTQKCFLDVQESVTTQVERLETQLHLEQDLDDQKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAALHPNKDAYKPITDADKIEDEVTRQVAKCKCAKRFQVEQIGDNKYRFFLGNQFGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCRVHHHGSKMLRSESNSSITTTQPTIAKGRTNMELREKFILADGASQGMAAFRPRGRRSRPSSRGASPNRSTSVSSQAAQAASPQVPATTTPKILHPLTRNYGKPWLTNSKMSTPCKAAECSDFPVPSAEGTPIQGSKLRLPGYLSGKGFHSGEDSGLITTAAARVRTQFADSKKTPSRPGSRAGSKAGSRASSRRGSDASDFDISEIQSVCSDVETVPQTHRPTPRAGSRPSTAKPSKIPTPQRKSPASKLDKSSKR","length":7818,"molWeight":888381,"crc64":"83808C0B91F7FA4F","md5":"366209AB0C4059C9B710EA87DEE7DDC4"},"extraAttributes":{"countByCommentType":{"FUNCTION":3,"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Domain":6,"Region":9,"Coiled coil":15,"Compositional bias":12},"uniParcId":"UPI000387B240"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"E7ETB9","uniProtkbId":"E7ETB9_HUMAN","entryAudit":{"firstPublicDate":"2011-03-08","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2022-05-25","entryVersion":98,"sequenceVersion":2},"annotationScore":4.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000431030.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00072808"}],"value":"Dystonin"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00077378"}],"value":"Bullous pemphigoid antigen 1"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00075126"}],"value":"Dystonia musculorum protein"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00077918"}],"value":"Hemidesmosomal plaque protein"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000431030.2"}],"value":"DST"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00054620"}],"value":"Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Mediates docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport through its interaction with TMEM108 and DCTN1"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00055817"}],"value":"Plays a structural role in the assembly of hemidesmosomes of epithelial cells; anchors keratin-containing intermediate filaments to the inner plaque of hemidesmosomes. Required for the regulation of keratinocyte polarity and motility; mediates integrin ITGB4 regulation of RAC1 activity"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00057123"}],"value":"Required for bundling actin filaments around the nucleus"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00060371"}],"value":"Cell junction, hemidesmosome","id":"SL-0137"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004193"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004193"}],"value":"Lipid-anchor","id":"SL-9901"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004489"}],"value":"Cell projection, axon","id":"SL-0279"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004544"}],"value":"Cytoplasm, cell cortex","id":"SL-0138"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004529"}],"value":"Cytoplasm, cytoskeleton, stress fiber","id":"SL-0501"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00060430"}],"value":"Cytoplasm, myofibril, sarcomere, H zone","id":"SL-0477"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004216"}],"value":"Cytoplasm, myofibril, sarcomere, Z line","id":"SL-0314"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004389"}],"value":"Endoplasmic reticulum membrane","id":"SL-0097"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004389"}],"value":"Single-pass membrane protein","id":"SL-9904"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004259"}],"value":"Nucleus envelope","id":"SL-0178"}}]}],"features":[{"type":"Domain","location":{"start":{"value":75,"modifier":"EXACT"},"end":{"value":178,"modifier":"EXACT"}},"description":"Calponin-homology (CH)","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50021"}]},{"type":"Domain","location":{"start":{"value":191,"modifier":"EXACT"},"end":{"value":295,"modifier":"EXACT"}},"description":"Calponin-homology (CH)","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50021"}]},{"type":"Domain","location":{"start":{"value":927,"modifier":"EXACT"},"end":{"value":984,"modifier":"EXACT"}},"description":"SH3","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50002"}]},{"type":"Domain","location":{"start":{"value":5042,"modifier":"EXACT"},"end":{"value":5077,"modifier":"EXACT"}},"description":"EF-hand","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50222"}]},{"type":"Domain","location":{"start":{"value":5078,"modifier":"EXACT"},"end":{"value":5113,"modifier":"EXACT"}},"description":"EF-hand","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50222"}]},{"type":"Domain","location":{"start":{"value":5118,"modifier":"EXACT"},"end":{"value":5190,"modifier":"EXACT"}},"description":"GAR","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51460"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":57,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":5214,"modifier":"EXACT"},"end":{"value":5263,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":5333,"modifier":"EXACT"},"end":{"value":5422,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":774,"modifier":"EXACT"},"end":{"value":808,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":1248,"modifier":"EXACT"},"end":{"value":1282,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":1458,"modifier":"EXACT"},"end":{"value":1488,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":1544,"modifier":"EXACT"},"end":{"value":1571,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":1677,"modifier":"EXACT"},"end":{"value":1711,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":1893,"modifier":"EXACT"},"end":{"value":1920,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":2300,"modifier":"EXACT"},"end":{"value":2327,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":2512,"modifier":"EXACT"},"end":{"value":2539,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":2726,"modifier":"EXACT"},"end":{"value":2787,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":3011,"modifier":"EXACT"},"end":{"value":3085,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":3158,"modifier":"EXACT"},"end":{"value":3240,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":4039,"modifier":"EXACT"},"end":{"value":4066,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":4145,"modifier":"EXACT"},"end":{"value":4189,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":4291,"modifier":"EXACT"},"end":{"value":4329,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":4800,"modifier":"EXACT"},"end":{"value":4830,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Compositional bias","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":10,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":5226,"modifier":"EXACT"},"end":{"value":5256,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":5342,"modifier":"EXACT"},"end":{"value":5356,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":5371,"modifier":"EXACT"},"end":{"value":5387,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023203"}],"id":"KW-0009","category":"Molecular function","name":"Actin-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022837"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10142"}],"id":"KW-0106","category":"Ligand","name":"Calcium"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022889"}],"id":"KW-0130","category":"Biological process","name":"Cell adhesion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022949"}],"id":"KW-0965","category":"Cellular component","name":"Cell junction"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023273"}],"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023054"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00792"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023212"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00792"}],"id":"KW-0206","category":"Cellular component","name":"Cytoskeleton"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022824"}],"id":"KW-0256","category":"Cellular component","name":"Endoplasmic reticulum"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022754"}],"id":"KW-0403","category":"Cellular component","name":"Intermediate filament"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022499"}],"id":"KW-1017","category":"PTM","name":"Isopeptide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023288"}],"id":"KW-0449","category":"PTM","name":"Lipoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10142"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022701"}],"id":"KW-0493","category":"Cellular component","name":"Microtubule"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023179"}],"id":"KW-0514","category":"Molecular function","name":"Muscle protein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023139"}],"id":"KW-0564","category":"PTM","name":"Palmitate"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"E7ETB9"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"E7ETB9"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022443"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00192"}],"id":"KW-0728","category":"Domain","name":"SH3 domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022843"}],"id":"KW-0832","category":"PTM","name":"Ubl conjugation"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000431030.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"14574404","citationType":"journal article","authors":["Mungall A.J.","Palmer S.A.","Sims S.K.","Edwards C.A.","Ashurst J.L.","Wilming L.","Jones M.C.","Horton R.","Hunt S.E.","Scott C.E.","Gilbert J.G.","Clamp M.E.","Bethel G.","Milne S.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Andrews T.D.","Ashwell R.I.","Babbage A.K.","Bagguley C.L.","Bailey J.","Banerjee R.","Barker D.J.","Barlow K.F.","Bates K.","Beare D.M.","Beasley H.","Beasley O.","Bird C.P.","Blakey S.","Bray-Allen S.","Brook J.","Brown A.J.","Brown J.Y.","Burford D.C.","Burrill W.","Burton J.","Carder C.","Carter N.P.","Chapman J.C.","Clark S.Y.","Clark G.","Clee C.M.","Clegg S.","Cobley V.","Collier R.E.","Collins J.E.","Colman L.K.","Corby N.R.","Coville G.J.","Culley K.M.","Dhami P.","Davies J.","Dunn M.","Earthrowl M.E.","Ellington A.E.","Evans K.A.","Faulkner L.","Francis M.D.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Ghori M.J.","Gilby L.M.","Gillson C.J.","Glithero R.J.","Grafham D.V.","Grant M.","Gribble S.","Griffiths C.","Griffiths M.","Hall R.","Halls K.S.","Hammond S.","Harley J.L.","Hart E.A.","Heath P.D.","Heathcott R.","Holmes S.J.","Howden P.J.","Howe K.L.","Howell G.R.","Huckle E.","Humphray S.J.","Humphries M.D.","Hunt A.R.","Johnson C.M.","Joy A.A.","Kay M.","Keenan S.J.","Kimberley A.M.","King A.","Laird G.K.","Langford C.","Lawlor S.","Leongamornlert D.A.","Leversha M.","Lloyd C.R.","Lloyd D.M.","Loveland J.E.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","Maslen G.L.","Matthews L.","McCann O.T.","McLaren S.J.","McLay K.","McMurray A.","Moore M.J.","Mullikin J.C.","Niblett D.","Nickerson T.","Novik K.L.","Oliver K.","Overton-Larty E.K.","Parker A.","Patel R.","Pearce A.V.","Peck A.I.","Phillimore B.","Phillips S.","Plumb R.W.","Porter K.M.","Ramsey Y.","Ranby S.A.","Rice C.M.","Ross M.T.","Searle S.M.","Sehra H.K.","Sheridan E.","Skuce C.D.","Smith S.","Smith M.","Spraggon L.","Squares S.L.","Steward C.A.","Sycamore N.","Tamlyn-Hall G.","Tester J.","Theaker A.J.","Thomas D.W.","Thorpe A.","Tracey A.","Tromans A.","Tubby B.","Wall M.","Wallis J.M.","West A.P.","White S.S.","Whitehead S.L.","Whittaker H.","Wild A.","Willey D.J.","Wilmer T.E.","Wood J.M.","Wray P.W.","Wyatt J.C.","Young L.","Younger R.M.","Bentley D.R.","Coulson A.","Durbin R.","Hubbard T.","Sulston J.E.","Dunham I.","Rogers J.","Beck S."],"citationCrossReferences":[{"database":"PubMed","id":"14574404"},{"database":"DOI","id":"10.1038/nature02055"}],"title":"The DNA sequence and analysis of human chromosome 6.","publicationDate":"2003","journal":"Nature","firstPage":"805","lastPage":"811","volume":"425"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000431030.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000431030.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Burckstummer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"21269460"}]},{"referenceNumber":5,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"24275569"}]},{"referenceNumber":6,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000431030.2"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL096710","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL137008","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL512422","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL512448","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL590005","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL590037","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"KF458172","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"SMR","id":"E7ETB9","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"E7ETB9","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"E7ETB9","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"18173","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"31066","properties":[{"key":"antibodies","value":"185 antibodies from 24 providers"}]},{"database":"Ensembl","id":"ENST00000520645.6","properties":[{"key":"ProteinId","value":"ENSP00000431030.2"},{"key":"GeneId","value":"ENSG00000151914.22"}]},{"database":"UCSC","id":"uc063pfc.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:1090","properties":[{"key":"GeneName","value":"DST"}]},{"database":"OpenTargets","id":"ENSG00000151914","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000151914","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000155008","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_004168_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"9479997at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"DST","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 6"}]},{"database":"Bgee","id":"ENSG00000151914","properties":[{"key":"ExpressionPatterns","value":"Expressed in corpus callosum and 207 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"E7ETB9","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0030424","properties":[{"key":"GoTerm","value":"C:axon"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005938","properties":[{"key":"GoTerm","value":"C:cell cortex"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0031252","properties":[{"key":"GoTerm","value":"C:cell leading edge"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0005789","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0031673","properties":[{"key":"GoTerm","value":"C:H zone"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0030056","properties":[{"key":"GoTerm","value":"C:hemidesmosome"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0045111","properties":[{"key":"GoTerm","value":"C:intermediate filament cytoskeleton"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0015630","properties":[{"key":"GoTerm","value":"C:microtubule cytoskeleton"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0005635","properties":[{"key":"GoTerm","value":"C:nuclear envelope"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0099513","properties":[{"key":"GoTerm","value":"C:polymeric cytoskeletal fiber"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0001725","properties":[{"key":"GoTerm","value":"C:stress fiber"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0030018","properties":[{"key":"GoTerm","value":"C:Z disc"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005509","properties":[{"key":"GoTerm","value":"F:calcium ion binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0008017","properties":[{"key":"GoTerm","value":"F:microtubule binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0042803","properties":[{"key":"GoTerm","value":"F:protein homodimerization activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0045104","properties":[{"key":"GoTerm","value":"P:intermediate filament cytoskeleton organization"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0000226","properties":[{"key":"GoTerm","value":"P:microtubule cytoskeleton organization"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd21236","properties":[{"key":"EntryName","value":"CH_DYST_rpt1"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd21239","properties":[{"key":"EntryName","value":"CH_DYST_rpt2"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd00051","properties":[{"key":"EntryName","value":"EFh"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd00176","properties":[{"key":"EntryName","value":"SPEC"},{"key":"MatchStatus","value":"15"}]},{"database":"FunFam","id":"1.20.58.60:FF:000144","properties":[{"key":"EntryName","value":"Dystonin"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000185","properties":[{"key":"EntryName","value":"Dystonin"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000009","properties":[{"key":"EntryName","value":"dystonin isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000074","properties":[{"key":"EntryName","value":"dystonin isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000077","properties":[{"key":"EntryName","value":"dystonin isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000093","properties":[{"key":"EntryName","value":"dystonin isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000111","properties":[{"key":"EntryName","value":"dystonin isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000114","properties":[{"key":"EntryName","value":"dystonin isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000121","properties":[{"key":"EntryName","value":"dystonin isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000052","properties":[{"key":"EntryName","value":"dystonin isoform X2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000060","properties":[{"key":"EntryName","value":"dystonin isoform X2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000069","properties":[{"key":"EntryName","value":"dystonin isoform X2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000085","properties":[{"key":"EntryName","value":"dystonin isoform X2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000094","properties":[{"key":"EntryName","value":"dystonin isoform X2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000098","properties":[{"key":"EntryName","value":"dystonin isoform X3"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.238.10:FF:000013","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.418.10:FF:000002","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.418.10:FF:000017","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000001","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"3"}]},{"database":"FunFam","id":"1.20.58.60:FF:000008","properties":[{"key":"EntryName","value":"microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000012","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000014","properties":[{"key":"EntryName","value":"microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000016","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000021","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000022","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000025","properties":[{"key":"EntryName","value":"microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000027","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000031","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.30.30.40:FF:000011","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.920.20:FF:000001","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000010","properties":[{"key":"EntryName","value":"plectin isoform X2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.58.1060","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.58.60","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"29"}]},{"database":"Gene3D","id":"1.10.418.10","properties":[{"key":"EntryName","value":"Calponin-like domain"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"1.10.238.10","properties":[{"key":"EntryName","value":"EF-hand"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.920.20","properties":[{"key":"EntryName","value":"Gas2-like domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.30.30.40","properties":[{"key":"EntryName","value":"SH3 Domains"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001589","properties":[{"key":"EntryName","value":"Actinin_actin-bd_CS"}]},{"database":"InterPro","id":"IPR001715","properties":[{"key":"EntryName","value":"CH_dom"}]},{"database":"InterPro","id":"IPR036872","properties":[{"key":"EntryName","value":"CH_dom_sf"}]},{"database":"InterPro","id":"IPR041615","properties":[{"key":"EntryName","value":"Desmoplakin_SH3"}]},{"database":"InterPro","id":"IPR041573","properties":[{"key":"EntryName","value":"Desmoplakin_Spectrin-like"}]},{"database":"InterPro","id":"IPR011992","properties":[{"key":"EntryName","value":"EF-hand-dom_pair"}]},{"database":"InterPro","id":"IPR018247","properties":[{"key":"EntryName","value":"EF_Hand_1_Ca_BS"}]},{"database":"InterPro","id":"IPR002048","properties":[{"key":"EntryName","value":"EF_hand_dom"}]},{"database":"InterPro","id":"IPR003108","properties":[{"key":"EntryName","value":"GAR_dom"}]},{"database":"InterPro","id":"IPR036534","properties":[{"key":"EntryName","value":"GAR_dom_sf"}]},{"database":"InterPro","id":"IPR049538","properties":[{"key":"EntryName","value":"PCN-like_spectrin-like_rpt"}]},{"database":"InterPro","id":"IPR043197","properties":[{"key":"EntryName","value":"Plakin"}]},{"database":"InterPro","id":"IPR001452","properties":[{"key":"EntryName","value":"SH3_domain"}]},{"database":"InterPro","id":"IPR018159","properties":[{"key":"EntryName","value":"Spectrin/alpha-actinin"}]},{"database":"InterPro","id":"IPR002017","properties":[{"key":"EntryName","value":"Spectrin_repeat"}]},{"database":"PANTHER","id":"PTHR23169:SF24","properties":[{"key":"EntryName","value":"DYSTONIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR23169","properties":[{"key":"EntryName","value":"ENVOPLAKIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00307","properties":[{"key":"EntryName","value":"CH"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF13499","properties":[{"key":"EntryName","value":"EF-hand_7"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02187","properties":[{"key":"EntryName","value":"GAS2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF17902","properties":[{"key":"EntryName","value":"SH3_10"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00435","properties":[{"key":"EntryName","value":"Spectrin"},{"key":"MatchStatus","value":"21"}]},{"database":"Pfam","id":"PF18373","properties":[{"key":"EntryName","value":"Spectrin_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF21019","properties":[{"key":"EntryName","value":"Spectrin_3"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF21020","properties":[{"key":"EntryName","value":"Spectrin_4"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF27015","properties":[{"key":"EntryName","value":"SR_desmoplakin_3"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF21097","properties":[{"key":"EntryName","value":"SR_plectin_7"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00033","properties":[{"key":"EntryName","value":"CH"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00054","properties":[{"key":"EntryName","value":"EFh"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00243","properties":[{"key":"EntryName","value":"GAS2"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00150","properties":[{"key":"EntryName","value":"SPEC"},{"key":"MatchStatus","value":"29"}]},{"database":"SUPFAM","id":"SSF47576","properties":[{"key":"EntryName","value":"Calponin-homology domain, CH-domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF47473","properties":[{"key":"EntryName","value":"EF-hand"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF143575","properties":[{"key":"EntryName","value":"GAS2 domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF46966","properties":[{"key":"EntryName","value":"Spectrin repeat"},{"key":"MatchStatus","value":"28"}]},{"database":"PROSITE","id":"PS00019","properties":[{"key":"EntryName","value":"ACTININ_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00020","properties":[{"key":"EntryName","value":"ACTININ_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50021","properties":[{"key":"EntryName","value":"CH"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS00018","properties":[{"key":"EntryName","value":"EF_HAND_1"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS50222","properties":[{"key":"EntryName","value":"EF_HAND_2"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS51460","properties":[{"key":"EntryName","value":"GAR"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50002","properties":[{"key":"EntryName","value":"SH3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSSGNASYRCSMSSSADFSDEDDFSQKSGSASPAPGDTLPWNLPKHERSKRKIQGGSVLDPAERAVLRIADERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPREKGRMRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGESEDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLANLEHAFYVAEKIGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPEGGEGIGANDVEVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKETEIPPKETEKSKIKRLYKLLEIWIEFGRIKLLQGYHPNDIEKEWGKLIIAMLEREKALRPEVERLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISGITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPSGLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAALHPNKDAYKPITDADKIEDEVTRQVAKCKCAKRFQVEQIGDNKYRFGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCRAKGRTNMELREKFILADGASQGMAAFRPRGRRSRPSSRGASPNRSTSVSSQAAQAASPQVPATTTPKILHPLTRNYGKPWLTNSKMSTPCKAAECSDFPVPSAEGTPIQGSKLRLPGYLSGKGFHSGEDSGLITTAAARVRTQFADSKKTPSRPGSRAGSKAGSRASSRRGSDASDFDISEIQSVCSDVETVPQTHRPTPRAGSRPSTAKPSKIPTPQRKSPASKLDKSSKR","length":5422,"molWeight":620269,"crc64":"828C64C643052E0C","md5":"4A1EEF1B5C79B82B6BC8A5B7977D4791"},"extraAttributes":{"countByCommentType":{"FUNCTION":3,"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Domain":6,"Region":3,"Coiled coil":15,"Compositional bias":4},"uniParcId":"UPI001E252471"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"F6QMI7","uniProtkbId":"F6QMI7_HUMAN","entryAudit":{"firstPublicDate":"2011-07-27","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2014-10-29","entryVersion":104,"sequenceVersion":2},"annotationScore":4.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000307959.7"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00072808"}],"value":"Dystonin"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00077378"}],"value":"Bullous pemphigoid antigen 1"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00075126"}],"value":"Dystonia musculorum protein"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00077918"}],"value":"Hemidesmosomal plaque protein"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000307959.7"}],"value":"DST"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00054620"}],"value":"Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Mediates docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport through its interaction with TMEM108 and DCTN1"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00055817"}],"value":"Plays a structural role in the assembly of hemidesmosomes of epithelial cells; anchors keratin-containing intermediate filaments to the inner plaque of hemidesmosomes. Required for the regulation of keratinocyte polarity and motility; mediates integrin ITGB4 regulation of RAC1 activity"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00057123"}],"value":"Required for bundling actin filaments around the nucleus"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00060371"}],"value":"Cell junction, hemidesmosome","id":"SL-0137"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004193"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004193"}],"value":"Lipid-anchor","id":"SL-9901"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004489"}],"value":"Cell projection, axon","id":"SL-0279"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004544"}],"value":"Cytoplasm, cell cortex","id":"SL-0138"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004529"}],"value":"Cytoplasm, cytoskeleton, stress fiber","id":"SL-0501"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00060430"}],"value":"Cytoplasm, myofibril, sarcomere, H zone","id":"SL-0477"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004216"}],"value":"Cytoplasm, myofibril, sarcomere, Z line","id":"SL-0314"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004389"}],"value":"Endoplasmic reticulum membrane","id":"SL-0097"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004389"}],"value":"Single-pass membrane protein","id":"SL-9904"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004259"}],"value":"Nucleus envelope","id":"SL-0178"}}]}],"features":[{"type":"Domain","location":{"start":{"value":75,"modifier":"EXACT"},"end":{"value":178,"modifier":"EXACT"}},"description":"Calponin-homology (CH)","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50021"}]},{"type":"Domain","location":{"start":{"value":191,"modifier":"EXACT"},"end":{"value":295,"modifier":"EXACT"}},"description":"Calponin-homology (CH)","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50021"}]},{"type":"Domain","location":{"start":{"value":927,"modifier":"EXACT"},"end":{"value":984,"modifier":"EXACT"}},"description":"SH3","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50002"}]},{"type":"Domain","location":{"start":{"value":5151,"modifier":"EXACT"},"end":{"value":5186,"modifier":"EXACT"}},"description":"EF-hand","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50222"}]},{"type":"Domain","location":{"start":{"value":5187,"modifier":"EXACT"},"end":{"value":5222,"modifier":"EXACT"}},"description":"EF-hand","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50222"}]},{"type":"Domain","location":{"start":{"value":5227,"modifier":"EXACT"},"end":{"value":5305,"modifier":"EXACT"}},"description":"GAR","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51460"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":57,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":5329,"modifier":"EXACT"},"end":{"value":5378,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":5448,"modifier":"EXACT"},"end":{"value":5537,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":774,"modifier":"EXACT"},"end":{"value":808,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":1248,"modifier":"EXACT"},"end":{"value":1282,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":1458,"modifier":"EXACT"},"end":{"value":1488,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":1544,"modifier":"EXACT"},"end":{"value":1571,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":1677,"modifier":"EXACT"},"end":{"value":1711,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":1893,"modifier":"EXACT"},"end":{"value":1920,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":2300,"modifier":"EXACT"},"end":{"value":2327,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":2512,"modifier":"EXACT"},"end":{"value":2539,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":2726,"modifier":"EXACT"},"end":{"value":2787,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":3011,"modifier":"EXACT"},"end":{"value":3085,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":3158,"modifier":"EXACT"},"end":{"value":3240,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":4148,"modifier":"EXACT"},"end":{"value":4175,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":4254,"modifier":"EXACT"},"end":{"value":4298,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":4400,"modifier":"EXACT"},"end":{"value":4438,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":4909,"modifier":"EXACT"},"end":{"value":4939,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Compositional bias","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":10,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":5341,"modifier":"EXACT"},"end":{"value":5371,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":5457,"modifier":"EXACT"},"end":{"value":5471,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":5486,"modifier":"EXACT"},"end":{"value":5502,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023203"}],"id":"KW-0009","category":"Molecular function","name":"Actin-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022837"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10142"}],"id":"KW-0106","category":"Ligand","name":"Calcium"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022889"}],"id":"KW-0130","category":"Biological process","name":"Cell adhesion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022949"}],"id":"KW-0965","category":"Cellular component","name":"Cell junction"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023273"}],"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023054"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00792"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023212"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00792"}],"id":"KW-0206","category":"Cellular component","name":"Cytoskeleton"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022824"}],"id":"KW-0256","category":"Cellular component","name":"Endoplasmic reticulum"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022754"}],"id":"KW-0403","category":"Cellular component","name":"Intermediate filament"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022499"}],"id":"KW-1017","category":"PTM","name":"Isopeptide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023288"}],"id":"KW-0449","category":"PTM","name":"Lipoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10142"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022701"}],"id":"KW-0493","category":"Cellular component","name":"Microtubule"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023179"}],"id":"KW-0514","category":"Molecular function","name":"Muscle protein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023139"}],"id":"KW-0564","category":"PTM","name":"Palmitate"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"F6QMI7"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"F6QMI7"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022443"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00192"}],"id":"KW-0728","category":"Domain","name":"SH3 domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022843"}],"id":"KW-0832","category":"PTM","name":"Ubl conjugation"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000307959.7"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"14574404","citationType":"journal article","authors":["Mungall A.J.","Palmer S.A.","Sims S.K.","Edwards C.A.","Ashurst J.L.","Wilming L.","Jones M.C.","Horton R.","Hunt S.E.","Scott C.E.","Gilbert J.G.","Clamp M.E.","Bethel G.","Milne S.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Andrews T.D.","Ashwell R.I.","Babbage A.K.","Bagguley C.L.","Bailey J.","Banerjee R.","Barker D.J.","Barlow K.F.","Bates K.","Beare D.M.","Beasley H.","Beasley O.","Bird C.P.","Blakey S.","Bray-Allen S.","Brook J.","Brown A.J.","Brown J.Y.","Burford D.C.","Burrill W.","Burton J.","Carder C.","Carter N.P.","Chapman J.C.","Clark S.Y.","Clark G.","Clee C.M.","Clegg S.","Cobley V.","Collier R.E.","Collins J.E.","Colman L.K.","Corby N.R.","Coville G.J.","Culley K.M.","Dhami P.","Davies J.","Dunn M.","Earthrowl M.E.","Ellington A.E.","Evans K.A.","Faulkner L.","Francis M.D.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Ghori M.J.","Gilby L.M.","Gillson C.J.","Glithero R.J.","Grafham D.V.","Grant M.","Gribble S.","Griffiths C.","Griffiths M.","Hall R.","Halls K.S.","Hammond S.","Harley J.L.","Hart E.A.","Heath P.D.","Heathcott R.","Holmes S.J.","Howden P.J.","Howe K.L.","Howell G.R.","Huckle E.","Humphray S.J.","Humphries M.D.","Hunt A.R.","Johnson C.M.","Joy A.A.","Kay M.","Keenan S.J.","Kimberley A.M.","King A.","Laird G.K.","Langford C.","Lawlor S.","Leongamornlert D.A.","Leversha M.","Lloyd C.R.","Lloyd D.M.","Loveland J.E.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","Maslen G.L.","Matthews L.","McCann O.T.","McLaren S.J.","McLay K.","McMurray A.","Moore M.J.","Mullikin J.C.","Niblett D.","Nickerson T.","Novik K.L.","Oliver K.","Overton-Larty E.K.","Parker A.","Patel R.","Pearce A.V.","Peck A.I.","Phillimore B.","Phillips S.","Plumb R.W.","Porter K.M.","Ramsey Y.","Ranby S.A.","Rice C.M.","Ross M.T.","Searle S.M.","Sehra H.K.","Sheridan E.","Skuce C.D.","Smith S.","Smith M.","Spraggon L.","Squares S.L.","Steward C.A.","Sycamore N.","Tamlyn-Hall G.","Tester J.","Theaker A.J.","Thomas D.W.","Thorpe A.","Tracey A.","Tromans A.","Tubby B.","Wall M.","Wallis J.M.","West A.P.","White S.S.","Whitehead S.L.","Whittaker H.","Wild A.","Willey D.J.","Wilmer T.E.","Wood J.M.","Wray P.W.","Wyatt J.C.","Young L.","Younger R.M.","Bentley D.R.","Coulson A.","Durbin R.","Hubbard T.","Sulston J.E.","Dunham I.","Rogers J.","Beck S."],"citationCrossReferences":[{"database":"PubMed","id":"14574404"},{"database":"DOI","id":"10.1038/nature02055"}],"title":"The DNA sequence and analysis of human chromosome 6.","publicationDate":"2003","journal":"Nature","firstPage":"805","lastPage":"811","volume":"425"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000307959.7"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000307959.7"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"18669648","citationType":"journal article","authors":["Dephoure N.","Zhou C.","Villen J.","Beausoleil S.A.","Bakalarski C.E.","Elledge S.J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"18669648"},{"database":"DOI","id":"10.1073/pnas.0805139105"}],"title":"A quantitative atlas of mitotic phosphorylation.","publicationDate":"2008","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10762","lastPage":"10767","volume":"105"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"18669648"}]},{"referenceNumber":5,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Burckstummer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"21269460"}]},{"referenceNumber":6,"citation":{"id":"21406692","citationType":"journal article","authors":["Rigbolt K.T.","Prokhorova T.A.","Akimov V.","Henningsen J.","Johansen P.T.","Kratchmarova I.","Kassem M.","Mann M.","Olsen J.V.","Blagoev B."],"citationCrossReferences":[{"database":"PubMed","id":"21406692"},{"database":"DOI","id":"10.1126/scisignal.2001570"}],"title":"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.","publicationDate":"2011","journal":"Sci. Signal.","firstPage":"RS3","lastPage":"RS3","volume":"4"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"21406692"}]},{"referenceNumber":7,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"23186163"}]},{"referenceNumber":8,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"24275569"}]},{"referenceNumber":9,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000307959.7"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL096710","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL137008","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL512422","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL512448","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL590005","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL590037","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"KF458172","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"NP_001138242.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001144770.2"}]},{"database":"SMR","id":"F6QMI7","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"F6QMI7","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"F6QMI7","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"27849","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"31066","properties":[{"key":"antibodies","value":"185 antibodies from 24 providers"}]},{"database":"DNASU","id":"667","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000312431.10","properties":[{"key":"ProteinId","value":"ENSP00000307959.7"},{"key":"GeneId","value":"ENSG00000151914.22"}]},{"database":"GeneID","id":"667","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc021zay.3","properties":[{"key":"OrganismName","value":"human"}]},{"database":"CTD","id":"667","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"667","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:1090","properties":[{"key":"GeneName","value":"DST"}]},{"database":"OpenTargets","id":"ENSG00000151914","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000151914","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000155008","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"9479997at2759","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"667","properties":[{"key":"hits","value":"16 hits in 1162 CRISPR screens"}]},{"database":"ChiTaRS","id":"DST","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 6"}]},{"database":"Bgee","id":"ENSG00000151914","properties":[{"key":"ExpressionPatterns","value":"Expressed in corpus callosum and 207 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"F6QMI7","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0030424","properties":[{"key":"GoTerm","value":"C:axon"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005938","properties":[{"key":"GoTerm","value":"C:cell cortex"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0031252","properties":[{"key":"GoTerm","value":"C:cell leading edge"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0005789","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0031673","properties":[{"key":"GoTerm","value":"C:H zone"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0030056","properties":[{"key":"GoTerm","value":"C:hemidesmosome"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0045111","properties":[{"key":"GoTerm","value":"C:intermediate filament cytoskeleton"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0015630","properties":[{"key":"GoTerm","value":"C:microtubule cytoskeleton"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0005635","properties":[{"key":"GoTerm","value":"C:nuclear envelope"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0099513","properties":[{"key":"GoTerm","value":"C:polymeric cytoskeletal fiber"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0001725","properties":[{"key":"GoTerm","value":"C:stress fiber"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0030018","properties":[{"key":"GoTerm","value":"C:Z disc"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005509","properties":[{"key":"GoTerm","value":"F:calcium ion binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0008017","properties":[{"key":"GoTerm","value":"F:microtubule binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0042803","properties":[{"key":"GoTerm","value":"F:protein homodimerization activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0045104","properties":[{"key":"GoTerm","value":"P:intermediate filament cytoskeleton organization"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0000226","properties":[{"key":"GoTerm","value":"P:microtubule cytoskeleton organization"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd21236","properties":[{"key":"EntryName","value":"CH_DYST_rpt1"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd21239","properties":[{"key":"EntryName","value":"CH_DYST_rpt2"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd00051","properties":[{"key":"EntryName","value":"EFh"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd00176","properties":[{"key":"EntryName","value":"SPEC"},{"key":"MatchStatus","value":"16"}]},{"database":"FunFam","id":"1.20.58.60:FF:000144","properties":[{"key":"EntryName","value":"Dystonin"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000185","properties":[{"key":"EntryName","value":"Dystonin"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000009","properties":[{"key":"EntryName","value":"dystonin isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000074","properties":[{"key":"EntryName","value":"dystonin isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000077","properties":[{"key":"EntryName","value":"dystonin isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000093","properties":[{"key":"EntryName","value":"dystonin isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000111","properties":[{"key":"EntryName","value":"dystonin isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000114","properties":[{"key":"EntryName","value":"dystonin isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000121","properties":[{"key":"EntryName","value":"dystonin isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000052","properties":[{"key":"EntryName","value":"dystonin isoform X2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000060","properties":[{"key":"EntryName","value":"dystonin isoform X2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000069","properties":[{"key":"EntryName","value":"dystonin isoform X2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000085","properties":[{"key":"EntryName","value":"dystonin isoform X2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000094","properties":[{"key":"EntryName","value":"dystonin isoform X2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000098","properties":[{"key":"EntryName","value":"dystonin isoform X3"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.238.10:FF:000013","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.418.10:FF:000002","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.418.10:FF:000017","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000001","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"3"}]},{"database":"FunFam","id":"1.20.58.60:FF:000008","properties":[{"key":"EntryName","value":"microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"2"}]},{"database":"FunFam","id":"1.20.58.60:FF:000012","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000014","properties":[{"key":"EntryName","value":"microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000016","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000021","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000022","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000025","properties":[{"key":"EntryName","value":"microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000027","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000031","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.30.30.40:FF:000011","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.920.20:FF:000001","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000010","properties":[{"key":"EntryName","value":"plectin isoform X2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.58.1060","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.58.60","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"30"}]},{"database":"Gene3D","id":"1.10.418.10","properties":[{"key":"EntryName","value":"Calponin-like domain"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"1.10.238.10","properties":[{"key":"EntryName","value":"EF-hand"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.920.20","properties":[{"key":"EntryName","value":"Gas2-like domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.30.30.40","properties":[{"key":"EntryName","value":"SH3 Domains"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001589","properties":[{"key":"EntryName","value":"Actinin_actin-bd_CS"}]},{"database":"InterPro","id":"IPR001715","properties":[{"key":"EntryName","value":"CH_dom"}]},{"database":"InterPro","id":"IPR036872","properties":[{"key":"EntryName","value":"CH_dom_sf"}]},{"database":"InterPro","id":"IPR041615","properties":[{"key":"EntryName","value":"Desmoplakin_SH3"}]},{"database":"InterPro","id":"IPR041573","properties":[{"key":"EntryName","value":"Desmoplakin_Spectrin-like"}]},{"database":"InterPro","id":"IPR011992","properties":[{"key":"EntryName","value":"EF-hand-dom_pair"}]},{"database":"InterPro","id":"IPR018247","properties":[{"key":"EntryName","value":"EF_Hand_1_Ca_BS"}]},{"database":"InterPro","id":"IPR002048","properties":[{"key":"EntryName","value":"EF_hand_dom"}]},{"database":"InterPro","id":"IPR003108","properties":[{"key":"EntryName","value":"GAR_dom"}]},{"database":"InterPro","id":"IPR036534","properties":[{"key":"EntryName","value":"GAR_dom_sf"}]},{"database":"InterPro","id":"IPR049538","properties":[{"key":"EntryName","value":"PCN-like_spectrin-like_rpt"}]},{"database":"InterPro","id":"IPR043197","properties":[{"key":"EntryName","value":"Plakin"}]},{"database":"InterPro","id":"IPR001452","properties":[{"key":"EntryName","value":"SH3_domain"}]},{"database":"InterPro","id":"IPR018159","properties":[{"key":"EntryName","value":"Spectrin/alpha-actinin"}]},{"database":"InterPro","id":"IPR002017","properties":[{"key":"EntryName","value":"Spectrin_repeat"}]},{"database":"PANTHER","id":"PTHR23169:SF24","properties":[{"key":"EntryName","value":"DYSTONIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR23169","properties":[{"key":"EntryName","value":"ENVOPLAKIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00307","properties":[{"key":"EntryName","value":"CH"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF13499","properties":[{"key":"EntryName","value":"EF-hand_7"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02187","properties":[{"key":"EntryName","value":"GAS2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF17902","properties":[{"key":"EntryName","value":"SH3_10"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00435","properties":[{"key":"EntryName","value":"Spectrin"},{"key":"MatchStatus","value":"21"}]},{"database":"Pfam","id":"PF18373","properties":[{"key":"EntryName","value":"Spectrin_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF21019","properties":[{"key":"EntryName","value":"Spectrin_3"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF21020","properties":[{"key":"EntryName","value":"Spectrin_4"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF27015","properties":[{"key":"EntryName","value":"SR_desmoplakin_3"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF21097","properties":[{"key":"EntryName","value":"SR_plectin_7"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00033","properties":[{"key":"EntryName","value":"CH"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00054","properties":[{"key":"EntryName","value":"EFh"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00243","properties":[{"key":"EntryName","value":"GAS2"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00150","properties":[{"key":"EntryName","value":"SPEC"},{"key":"MatchStatus","value":"30"}]},{"database":"SUPFAM","id":"SSF47576","properties":[{"key":"EntryName","value":"Calponin-homology domain, CH-domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF47473","properties":[{"key":"EntryName","value":"EF-hand"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF143575","properties":[{"key":"EntryName","value":"GAS2 domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF46966","properties":[{"key":"EntryName","value":"Spectrin repeat"},{"key":"MatchStatus","value":"27"}]},{"database":"PROSITE","id":"PS00019","properties":[{"key":"EntryName","value":"ACTININ_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00020","properties":[{"key":"EntryName","value":"ACTININ_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50021","properties":[{"key":"EntryName","value":"CH"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS00018","properties":[{"key":"EntryName","value":"EF_HAND_1"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS50222","properties":[{"key":"EntryName","value":"EF_HAND_2"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS51460","properties":[{"key":"EntryName","value":"GAR"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50002","properties":[{"key":"EntryName","value":"SH3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSSGNASYRCSMSSSADFSDEDDFSQKSGSASPAPGDTLPWNLPKHERSKRKIQGGSVLDPAERAVLRIADERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPREKGRMRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGESEDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLANLEHAFYVAEKIGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPEGGEGIGANDVEVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKETEIPPKETEKSKIKRLYKLLEIWIEFGRIKLLQGYHPNDIEKEWGKLIIAMLEREKALRPEVERLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISGITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPSGLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAALHPNKDAYKPITDADKIEDEVTRQVAKCKCAKRFQVEQIGDNKYRFFLGNQFGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCRAKGRTNMELREKFILADGASQGMAAFRPRGRRSRPSSRGASPNRSTSVSSQAAQAASPQVPATTTPKILHPLTRNYGKPWLTNSKMSTPCKAAECSDFPVPSAEGTPIQGSKLRLPGYLSGKGFHSGEDSGLITTAAARVRTQFADSKKTPSRPGSRAGSKAGSRASSRRGSDASDFDISEIQSVCSDVETVPQTHRPTPRAGSRPSTAKPSKIPTPQRKSPASKLDKSSKR","length":5537,"molWeight":633667,"crc64":"AEDAFBD744EB31A8","md5":"84D19351B2FD5F009EFC667A20140369"},"extraAttributes":{"countByCommentType":{"FUNCTION":3,"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Domain":6,"Region":3,"Coiled coil":15,"Compositional bias":4},"uniParcId":"UPI0001929509"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A494C073","uniProtkbId":"A0A494C073_HUMAN","entryAudit":{"firstPublicDate":"2019-06-05","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2019-06-05","entryVersion":39,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000498389.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000498389.1"}],"value":"Dystonin"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000498389.1"}],"value":"DST"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004245"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00792"}],"value":"Cytoplasm, cytoskeleton","id":"SL-0090"}}]}],"features":[{"type":"Domain","location":{"start":{"value":980,"modifier":"EXACT"},"end":{"value":1015,"modifier":"EXACT"}},"description":"EF-hand","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50222"}]},{"type":"Domain","location":{"start":{"value":1016,"modifier":"EXACT"},"end":{"value":1051,"modifier":"EXACT"}},"description":"EF-hand","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50222"}]},{"type":"Domain","location":{"start":{"value":1056,"modifier":"EXACT"},"end":{"value":1128,"modifier":"EXACT"}},"description":"GAR","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51460"}]},{"type":"Region","location":{"start":{"value":1136,"modifier":"EXACT"},"end":{"value":1158,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1172,"modifier":"EXACT"},"end":{"value":1229,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1258,"modifier":"EXACT"},"end":{"value":1347,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":83,"modifier":"EXACT"},"end":{"value":127,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":229,"modifier":"EXACT"},"end":{"value":267,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":738,"modifier":"EXACT"},"end":{"value":768,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Compositional bias","location":{"start":{"value":1139,"modifier":"EXACT"},"end":{"value":1151,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1188,"modifier":"EXACT"},"end":{"value":1218,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1267,"modifier":"EXACT"},"end":{"value":1281,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1296,"modifier":"EXACT"},"end":{"value":1312,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000498389.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022837"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10142"}],"id":"KW-0106","category":"Ligand","name":"Calcium"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00792"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023212"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00792"}],"id":"KW-0206","category":"Cellular component","name":"Cytoskeleton"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10142"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0A494C073"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0A494C073"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000498389.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"14574404","citationType":"journal article","authors":["Mungall A.J.","Palmer S.A.","Sims S.K.","Edwards C.A.","Ashurst J.L.","Wilming L.","Jones M.C.","Horton R.","Hunt S.E.","Scott C.E.","Gilbert J.G.","Clamp M.E.","Bethel G.","Milne S.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Andrews T.D.","Ashwell R.I.","Babbage A.K.","Bagguley C.L.","Bailey J.","Banerjee R.","Barker D.J.","Barlow K.F.","Bates K.","Beare D.M.","Beasley H.","Beasley O.","Bird C.P.","Blakey S.","Bray-Allen S.","Brook J.","Brown A.J.","Brown J.Y.","Burford D.C.","Burrill W.","Burton J.","Carder C.","Carter N.P.","Chapman J.C.","Clark S.Y.","Clark G.","Clee C.M.","Clegg S.","Cobley V.","Collier R.E.","Collins J.E.","Colman L.K.","Corby N.R.","Coville G.J.","Culley K.M.","Dhami P.","Davies J.","Dunn M.","Earthrowl M.E.","Ellington A.E.","Evans K.A.","Faulkner L.","Francis M.D.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Ghori M.J.","Gilby L.M.","Gillson C.J.","Glithero R.J.","Grafham D.V.","Grant M.","Gribble S.","Griffiths C.","Griffiths M.","Hall R.","Halls K.S.","Hammond S.","Harley J.L.","Hart E.A.","Heath P.D.","Heathcott R.","Holmes S.J.","Howden P.J.","Howe K.L.","Howell G.R.","Huckle E.","Humphray S.J.","Humphries M.D.","Hunt A.R.","Johnson C.M.","Joy A.A.","Kay M.","Keenan S.J.","Kimberley A.M.","King A.","Laird G.K.","Langford C.","Lawlor S.","Leongamornlert D.A.","Leversha M.","Lloyd C.R.","Lloyd D.M.","Loveland J.E.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","Maslen G.L.","Matthews L.","McCann O.T.","McLaren S.J.","McLay K.","McMurray A.","Moore M.J.","Mullikin J.C.","Niblett D.","Nickerson T.","Novik K.L.","Oliver K.","Overton-Larty E.K.","Parker A.","Patel R.","Pearce A.V.","Peck A.I.","Phillimore B.","Phillips S.","Plumb R.W.","Porter K.M.","Ramsey Y.","Ranby S.A.","Rice C.M.","Ross M.T.","Searle S.M.","Sehra H.K.","Sheridan E.","Skuce C.D.","Smith S.","Smith M.","Spraggon L.","Squares S.L.","Steward C.A.","Sycamore N.","Tamlyn-Hall G.","Tester J.","Theaker A.J.","Thomas D.W.","Thorpe A.","Tracey A.","Tromans A.","Tubby B.","Wall M.","Wallis J.M.","West A.P.","White S.S.","Whitehead S.L.","Whittaker H.","Wild A.","Willey D.J.","Wilmer T.E.","Wood J.M.","Wray P.W.","Wyatt J.C.","Young L.","Younger R.M.","Bentley D.R.","Coulson A.","Durbin R.","Hubbard T.","Sulston J.E.","Dunham I.","Rogers J.","Beck S."],"citationCrossReferences":[{"database":"PubMed","id":"14574404"},{"database":"DOI","id":"10.1038/nature02055"}],"title":"The DNA sequence and analysis of human chromosome 6.","publicationDate":"2003","journal":"Nature","firstPage":"805","lastPage":"811","volume":"425"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000498389.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000498389.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000498389.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL096710","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL137008","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL512422","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL512448","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL590005","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL590037","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"KF458172","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"MassIVE","id":"A0A494C073","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"31066","properties":[{"key":"antibodies","value":"185 antibodies from 24 providers"}]},{"database":"Ensembl","id":"ENST00000651790.1","properties":[{"key":"ProteinId","value":"ENSP00000498389.1"},{"key":"GeneId","value":"ENSG00000151914.22"}]},{"database":"HGNC","id":"HGNC:1090","properties":[{"key":"GeneName","value":"DST"}]},{"database":"OpenTargets","id":"ENSG00000151914","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000151914","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000155008","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"9479997at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"DST","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 6"}]},{"database":"Bgee","id":"ENSG00000151914","properties":[{"key":"ExpressionPatterns","value":"Expressed in corpus callosum and 207 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"A0A494C073","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005856","properties":[{"key":"GoTerm","value":"C:cytoskeleton"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005509","properties":[{"key":"GoTerm","value":"F:calcium ion binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0008017","properties":[{"key":"GoTerm","value":"F:microtubule binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0045104","properties":[{"key":"GoTerm","value":"P:intermediate filament cytoskeleton organization"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd00051","properties":[{"key":"EntryName","value":"EFh"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd00176","properties":[{"key":"EntryName","value":"SPEC"},{"key":"MatchStatus","value":"5"}]},{"database":"FunFam","id":"1.20.58.60:FF:000077","properties":[{"key":"EntryName","value":"dystonin isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.920.20:FF:000002","properties":[{"key":"EntryName","value":"dystonin isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.238.10:FF:000013","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000001","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"3"}]},{"database":"FunFam","id":"1.20.58.60:FF:000012","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000014","properties":[{"key":"EntryName","value":"microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000016","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000025","properties":[{"key":"EntryName","value":"microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.58.60","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"8"}]},{"database":"Gene3D","id":"1.10.238.10","properties":[{"key":"EntryName","value":"EF-hand"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.920.20","properties":[{"key":"EntryName","value":"Gas2-like domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR011992","properties":[{"key":"EntryName","value":"EF-hand-dom_pair"}]},{"database":"InterPro","id":"IPR018247","properties":[{"key":"EntryName","value":"EF_Hand_1_Ca_BS"}]},{"database":"InterPro","id":"IPR002048","properties":[{"key":"EntryName","value":"EF_hand_dom"}]},{"database":"InterPro","id":"IPR003108","properties":[{"key":"EntryName","value":"GAR_dom"}]},{"database":"InterPro","id":"IPR036534","properties":[{"key":"EntryName","value":"GAR_dom_sf"}]},{"database":"InterPro","id":"IPR043197","properties":[{"key":"EntryName","value":"Plakin"}]},{"database":"InterPro","id":"IPR018159","properties":[{"key":"EntryName","value":"Spectrin/alpha-actinin"}]},{"database":"InterPro","id":"IPR002017","properties":[{"key":"EntryName","value":"Spectrin_repeat"}]},{"database":"PANTHER","id":"PTHR23169:SF24","properties":[{"key":"EntryName","value":"DYSTONIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR23169","properties":[{"key":"EntryName","value":"ENVOPLAKIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF13499","properties":[{"key":"EntryName","value":"EF-hand_7"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02187","properties":[{"key":"EntryName","value":"GAS2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00435","properties":[{"key":"EntryName","value":"Spectrin"},{"key":"MatchStatus","value":"7"}]},{"database":"SMART","id":"SM00054","properties":[{"key":"EntryName","value":"EFh"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00243","properties":[{"key":"EntryName","value":"GAS2"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00150","properties":[{"key":"EntryName","value":"SPEC"},{"key":"MatchStatus","value":"8"}]},{"database":"SUPFAM","id":"SSF47473","properties":[{"key":"EntryName","value":"EF-hand"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF143575","properties":[{"key":"EntryName","value":"GAS2 domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF46966","properties":[{"key":"EntryName","value":"Spectrin repeat"},{"key":"MatchStatus","value":"6"}]},{"database":"PROSITE","id":"PS00018","properties":[{"key":"EntryName","value":"EF_HAND_1"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS50222","properties":[{"key":"EntryName","value":"EF_HAND_2"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS51460","properties":[{"key":"EntryName","value":"GAR"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"XINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAALHPNKDAYKPITDADKIEDEVTRQVAKCKCAKRFQVEQIGDNKYRFGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCRVHHHGSKMLRSESNSSITTTQPTIAKGRTNMELREKFILADGASQGMAAFRPRGRRSRPSSRGASPNRSTSVSSQAAQAASPQVPATTTPKGTPIQGSKLRLPGYLSGKGFHSGEDSGLITTAAARVRTQFADSKKTPSRPGSRAGSKAGSRASSRRGSDASDFDISEIQSVCSDVETVPQTHRPTPRAGSRPSTAKPSKIPTPQRKSPASKLDKSSKR","length":1347,"molWeight":153045,"crc64":"D3117CCE84E99E32","md5":"B07D0E0E5B57E5C7386D3443AB95AA92"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Domain":3,"Region":3,"Coiled coil":3,"Compositional bias":4,"Non-terminal residue":1},"uniParcId":"UPI00108F6123"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A494C1U5","uniProtkbId":"A0A494C1U5_HUMAN","entryAudit":{"firstPublicDate":"2019-06-05","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2019-06-05","entryVersion":39,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000499198.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000499198.1"}],"value":"Dystonin"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000499198.1"}],"value":"DST"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004245"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00792"}],"value":"Cytoplasm, cytoskeleton","id":"SL-0090"}}]}],"features":[{"type":"Domain","location":{"start":{"value":245,"modifier":"EXACT"},"end":{"value":280,"modifier":"EXACT"}},"description":"EF-hand","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50222"}]},{"type":"Domain","location":{"start":{"value":281,"modifier":"EXACT"},"end":{"value":316,"modifier":"EXACT"}},"description":"EF-hand","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50222"}]},{"type":"Domain","location":{"start":{"value":321,"modifier":"EXACT"},"end":{"value":393,"modifier":"EXACT"}},"description":"GAR","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51460"}]},{"type":"Region","location":{"start":{"value":417,"modifier":"EXACT"},"end":{"value":466,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":536,"modifier":"EXACT"},"end":{"value":625,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":3,"modifier":"EXACT"},"end":{"value":33,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Compositional bias","location":{"start":{"value":429,"modifier":"EXACT"},"end":{"value":459,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":545,"modifier":"EXACT"},"end":{"value":559,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":574,"modifier":"EXACT"},"end":{"value":590,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000499198.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022837"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10142"}],"id":"KW-0106","category":"Ligand","name":"Calcium"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00792"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023212"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00792"}],"id":"KW-0206","category":"Cellular component","name":"Cytoskeleton"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10142"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0A494C1U5"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0A494C1U5"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000499198.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"14574404","citationType":"journal article","authors":["Mungall A.J.","Palmer S.A.","Sims S.K.","Edwards C.A.","Ashurst J.L.","Wilming L.","Jones M.C.","Horton R.","Hunt S.E.","Scott C.E.","Gilbert J.G.","Clamp M.E.","Bethel G.","Milne S.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Andrews T.D.","Ashwell R.I.","Babbage A.K.","Bagguley C.L.","Bailey J.","Banerjee R.","Barker D.J.","Barlow K.F.","Bates K.","Beare D.M.","Beasley H.","Beasley O.","Bird C.P.","Blakey S.","Bray-Allen S.","Brook J.","Brown A.J.","Brown J.Y.","Burford D.C.","Burrill W.","Burton J.","Carder C.","Carter N.P.","Chapman J.C.","Clark S.Y.","Clark G.","Clee C.M.","Clegg S.","Cobley V.","Collier R.E.","Collins J.E.","Colman L.K.","Corby N.R.","Coville G.J.","Culley K.M.","Dhami P.","Davies J.","Dunn M.","Earthrowl M.E.","Ellington A.E.","Evans K.A.","Faulkner L.","Francis M.D.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Ghori M.J.","Gilby L.M.","Gillson C.J.","Glithero R.J.","Grafham D.V.","Grant M.","Gribble S.","Griffiths C.","Griffiths M.","Hall R.","Halls K.S.","Hammond S.","Harley J.L.","Hart E.A.","Heath P.D.","Heathcott R.","Holmes S.J.","Howden P.J.","Howe K.L.","Howell G.R.","Huckle E.","Humphray S.J.","Humphries M.D.","Hunt A.R.","Johnson C.M.","Joy A.A.","Kay M.","Keenan S.J.","Kimberley A.M.","King A.","Laird G.K.","Langford C.","Lawlor S.","Leongamornlert D.A.","Leversha M.","Lloyd C.R.","Lloyd D.M.","Loveland J.E.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","Maslen G.L.","Matthews L.","McCann O.T.","McLaren S.J.","McLay K.","McMurray A.","Moore M.J.","Mullikin J.C.","Niblett D.","Nickerson T.","Novik K.L.","Oliver K.","Overton-Larty E.K.","Parker A.","Patel R.","Pearce A.V.","Peck A.I.","Phillimore B.","Phillips S.","Plumb R.W.","Porter K.M.","Ramsey Y.","Ranby S.A.","Rice C.M.","Ross M.T.","Searle S.M.","Sehra H.K.","Sheridan E.","Skuce C.D.","Smith S.","Smith M.","Spraggon L.","Squares S.L.","Steward C.A.","Sycamore N.","Tamlyn-Hall G.","Tester J.","Theaker A.J.","Thomas D.W.","Thorpe A.","Tracey A.","Tromans A.","Tubby B.","Wall M.","Wallis J.M.","West A.P.","White S.S.","Whitehead S.L.","Whittaker H.","Wild A.","Willey D.J.","Wilmer T.E.","Wood J.M.","Wray P.W.","Wyatt J.C.","Young L.","Younger R.M.","Bentley D.R.","Coulson A.","Durbin R.","Hubbard T.","Sulston J.E.","Dunham I.","Rogers J.","Beck S."],"citationCrossReferences":[{"database":"PubMed","id":"14574404"},{"database":"DOI","id":"10.1038/nature02055"}],"title":"The DNA sequence and analysis of human chromosome 6.","publicationDate":"2003","journal":"Nature","firstPage":"805","lastPage":"811","volume":"425"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000499198.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000499198.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000499198.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL096710","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL137008","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL512422","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL512448","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL590005","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL590037","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"KF458172","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"MassIVE","id":"A0A494C1U5","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"31066","properties":[{"key":"antibodies","value":"185 antibodies from 24 providers"}]},{"database":"Ensembl","id":"ENST00000651289.1","properties":[{"key":"ProteinId","value":"ENSP00000499198.1"},{"key":"GeneId","value":"ENSG00000151914.22"}]},{"database":"HGNC","id":"HGNC:1090","properties":[{"key":"GeneName","value":"DST"}]},{"database":"OpenTargets","id":"ENSG00000151914","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000151914","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000155008","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"9479997at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"DST","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 6"}]},{"database":"Bgee","id":"ENSG00000151914","properties":[{"key":"ExpressionPatterns","value":"Expressed in corpus callosum and 207 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"A0A494C1U5","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005856","properties":[{"key":"GoTerm","value":"C:cytoskeleton"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005509","properties":[{"key":"GoTerm","value":"F:calcium ion binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0008017","properties":[{"key":"GoTerm","value":"F:microtubule binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0045104","properties":[{"key":"GoTerm","value":"P:intermediate filament cytoskeleton organization"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd00051","properties":[{"key":"EntryName","value":"EFh"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd00176","properties":[{"key":"EntryName","value":"SPEC"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.238.10:FF:000013","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000025","properties":[{"key":"EntryName","value":"microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.920.20:FF:000001","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.58.60","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"1.10.238.10","properties":[{"key":"EntryName","value":"EF-hand"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.920.20","properties":[{"key":"EntryName","value":"Gas2-like domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR011992","properties":[{"key":"EntryName","value":"EF-hand-dom_pair"}]},{"database":"InterPro","id":"IPR018247","properties":[{"key":"EntryName","value":"EF_Hand_1_Ca_BS"}]},{"database":"InterPro","id":"IPR002048","properties":[{"key":"EntryName","value":"EF_hand_dom"}]},{"database":"InterPro","id":"IPR003108","properties":[{"key":"EntryName","value":"GAR_dom"}]},{"database":"InterPro","id":"IPR036534","properties":[{"key":"EntryName","value":"GAR_dom_sf"}]},{"database":"InterPro","id":"IPR043197","properties":[{"key":"EntryName","value":"Plakin"}]},{"database":"InterPro","id":"IPR018159","properties":[{"key":"EntryName","value":"Spectrin/alpha-actinin"}]},{"database":"InterPro","id":"IPR002017","properties":[{"key":"EntryName","value":"Spectrin_repeat"}]},{"database":"PANTHER","id":"PTHR23169:SF24","properties":[{"key":"EntryName","value":"DYSTONIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR23169","properties":[{"key":"EntryName","value":"ENVOPLAKIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF13499","properties":[{"key":"EntryName","value":"EF-hand_7"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02187","properties":[{"key":"EntryName","value":"GAS2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00435","properties":[{"key":"EntryName","value":"Spectrin"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00054","properties":[{"key":"EntryName","value":"EFh"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00243","properties":[{"key":"EntryName","value":"GAS2"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00150","properties":[{"key":"EntryName","value":"SPEC"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF47473","properties":[{"key":"EntryName","value":"EF-hand"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF143575","properties":[{"key":"EntryName","value":"GAS2 domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF46966","properties":[{"key":"EntryName","value":"Spectrin repeat"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00018","properties":[{"key":"EntryName","value":"EF_HAND_1"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS50222","properties":[{"key":"EntryName","value":"EF_HAND_2"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS51460","properties":[{"key":"EntryName","value":"GAR"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"XDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAALHPNKDAYKPITDADKIEDEVTRQVAKCKCAKRFQVEQIGDNKYRFGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCRAKGRTNMELREKFILADGASQGMAAFRPRGRRSRPSSRGASPNRSTSVSSQAAQAASPQVPATTTPKILHPLTRNYGKPWLTNSKMSTPCKAAECSDFPVPSAEGTPIQGSKLRLPGYLSGKGFHSGEDSGLITTAAARVRTQFADSKKTPSRPGSRAGSKAGSRASSRRGSDASDFDISEIQSVCSDVETVPQTHRPTPRAGSRPSTAKPSKIPTPQRKSPASKLDKSSKR","length":625,"molWeight":70428,"crc64":"AD9D86AC0D310863","md5":"15F1119159811CCCC61EE446EFBE3F8E"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Domain":3,"Region":2,"Coiled coil":1,"Compositional bias":3,"Non-terminal residue":1},"uniParcId":"UPI0010894D80"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A0U1RQJ2","uniProtkbId":"A0A0U1RQJ2_HUMAN","entryAudit":{"firstPublicDate":"2016-02-17","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2019-06-05","entryVersion":56,"sequenceVersion":2},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000489032.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000489032.2"}],"value":"Dystonin"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000489032.2"}],"value":"DST"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004245"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00792"}],"value":"Cytoplasm, cytoskeleton","id":"SL-0090"}}]}],"features":[{"type":"Domain","location":{"start":{"value":2303,"modifier":"EXACT"},"end":{"value":2338,"modifier":"EXACT"}},"description":"EF-hand","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50222"}]},{"type":"Domain","location":{"start":{"value":2339,"modifier":"EXACT"},"end":{"value":2374,"modifier":"EXACT"}},"description":"EF-hand","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50222"}]},{"type":"Domain","location":{"start":{"value":2379,"modifier":"EXACT"},"end":{"value":2457,"modifier":"EXACT"}},"description":"GAR","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51460"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":177,"modifier":"EXACT"},"end":{"value":201,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":2464,"modifier":"EXACT"},"end":{"value":2485,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":2501,"modifier":"EXACT"},"end":{"value":2558,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":2587,"modifier":"EXACT"},"end":{"value":2676,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":1300,"modifier":"EXACT"},"end":{"value":1327,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":1406,"modifier":"EXACT"},"end":{"value":1450,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":1552,"modifier":"EXACT"},"end":{"value":1590,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":2061,"modifier":"EXACT"},"end":{"value":2091,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Compositional bias","location":{"start":{"value":2468,"modifier":"EXACT"},"end":{"value":2480,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":2517,"modifier":"EXACT"},"end":{"value":2547,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":2596,"modifier":"EXACT"},"end":{"value":2610,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":2625,"modifier":"EXACT"},"end":{"value":2641,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022837"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10142"}],"id":"KW-0106","category":"Ligand","name":"Calcium"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00792"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023212"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00792"}],"id":"KW-0206","category":"Cellular component","name":"Cytoskeleton"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10142"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0A0U1RQJ2"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0A0U1RQJ2"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000489032.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"14574404","citationType":"journal article","authors":["Mungall A.J.","Palmer S.A.","Sims S.K.","Edwards C.A.","Ashurst J.L.","Wilming L.","Jones M.C.","Horton R.","Hunt S.E.","Scott C.E.","Gilbert J.G.","Clamp M.E.","Bethel G.","Milne S.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Andrews T.D.","Ashwell R.I.","Babbage A.K.","Bagguley C.L.","Bailey J.","Banerjee R.","Barker D.J.","Barlow K.F.","Bates K.","Beare D.M.","Beasley H.","Beasley O.","Bird C.P.","Blakey S.","Bray-Allen S.","Brook J.","Brown A.J.","Brown J.Y.","Burford D.C.","Burrill W.","Burton J.","Carder C.","Carter N.P.","Chapman J.C.","Clark S.Y.","Clark G.","Clee C.M.","Clegg S.","Cobley V.","Collier R.E.","Collins J.E.","Colman L.K.","Corby N.R.","Coville G.J.","Culley K.M.","Dhami P.","Davies J.","Dunn M.","Earthrowl M.E.","Ellington A.E.","Evans K.A.","Faulkner L.","Francis M.D.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Ghori M.J.","Gilby L.M.","Gillson C.J.","Glithero R.J.","Grafham D.V.","Grant M.","Gribble S.","Griffiths C.","Griffiths M.","Hall R.","Halls K.S.","Hammond S.","Harley J.L.","Hart E.A.","Heath P.D.","Heathcott R.","Holmes S.J.","Howden P.J.","Howe K.L.","Howell G.R.","Huckle E.","Humphray S.J.","Humphries M.D.","Hunt A.R.","Johnson C.M.","Joy A.A.","Kay M.","Keenan S.J.","Kimberley A.M.","King A.","Laird G.K.","Langford C.","Lawlor S.","Leongamornlert D.A.","Leversha M.","Lloyd C.R.","Lloyd D.M.","Loveland J.E.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","Maslen G.L.","Matthews L.","McCann O.T.","McLaren S.J.","McLay K.","McMurray A.","Moore M.J.","Mullikin J.C.","Niblett D.","Nickerson T.","Novik K.L.","Oliver K.","Overton-Larty E.K.","Parker A.","Patel R.","Pearce A.V.","Peck A.I.","Phillimore B.","Phillips S.","Plumb R.W.","Porter K.M.","Ramsey Y.","Ranby S.A.","Rice C.M.","Ross M.T.","Searle S.M.","Sehra H.K.","Sheridan E.","Skuce C.D.","Smith S.","Smith M.","Spraggon L.","Squares S.L.","Steward C.A.","Sycamore N.","Tamlyn-Hall G.","Tester J.","Theaker A.J.","Thomas D.W.","Thorpe A.","Tracey A.","Tromans A.","Tubby B.","Wall M.","Wallis J.M.","West A.P.","White S.S.","Whitehead S.L.","Whittaker H.","Wild A.","Willey D.J.","Wilmer T.E.","Wood J.M.","Wray P.W.","Wyatt J.C.","Young L.","Younger R.M.","Bentley D.R.","Coulson A.","Durbin R.","Hubbard T.","Sulston J.E.","Dunham I.","Rogers J.","Beck S."],"citationCrossReferences":[{"database":"PubMed","id":"14574404"},{"database":"DOI","id":"10.1038/nature02055"}],"title":"The DNA sequence and analysis of human chromosome 6.","publicationDate":"2003","journal":"Nature","firstPage":"805","lastPage":"811","volume":"425"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000489032.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000489032.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Burckstummer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"21269460"}]},{"referenceNumber":5,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000489032.2"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL096710","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL137008","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL512422","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL512448","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL590005","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL590037","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"KF458172","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"SMR","id":"A0A0U1RQJ2","properties":[{"key":"Description","value":"-"}]},{"database":"IntAct","id":"A0A0U1RQJ2","properties":[{"key":"Interactions","value":"2"}]},{"database":"MassIVE","id":"A0A0U1RQJ2","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"31066","properties":[{"key":"antibodies","value":"185 antibodies from 24 providers"}]},{"database":"Ensembl","id":"ENST00000340834.10","properties":[{"key":"ProteinId","value":"ENSP00000489032.2"},{"key":"GeneId","value":"ENSG00000151914.22"}]},{"database":"HGNC","id":"HGNC:1090","properties":[{"key":"GeneName","value":"DST"}]},{"database":"OpenTargets","id":"ENSG00000151914","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000151914","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000155008","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"PDENFKM","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9479997at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"DST","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 6"}]},{"database":"Bgee","id":"ENSG00000151914","properties":[{"key":"ExpressionPatterns","value":"Expressed in corpus callosum and 207 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"A0A0U1RQJ2","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005856","properties":[{"key":"GoTerm","value":"C:cytoskeleton"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005509","properties":[{"key":"GoTerm","value":"F:calcium ion binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0008017","properties":[{"key":"GoTerm","value":"F:microtubule binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0045104","properties":[{"key":"GoTerm","value":"P:intermediate filament cytoskeleton organization"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd00051","properties":[{"key":"EntryName","value":"EFh"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd00176","properties":[{"key":"EntryName","value":"SPEC"},{"key":"MatchStatus","value":"11"}]},{"database":"FunFam","id":"1.20.58.60:FF:000144","properties":[{"key":"EntryName","value":"Dystonin"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000074","properties":[{"key":"EntryName","value":"dystonin isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000077","properties":[{"key":"EntryName","value":"dystonin isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.920.20:FF:000002","properties":[{"key":"EntryName","value":"dystonin isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000069","properties":[{"key":"EntryName","value":"dystonin isoform X2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.238.10:FF:000013","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000001","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"3"}]},{"database":"FunFam","id":"1.20.58.60:FF:000008","properties":[{"key":"EntryName","value":"microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"2"}]},{"database":"FunFam","id":"1.20.58.60:FF:000012","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000014","properties":[{"key":"EntryName","value":"microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000016","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000021","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000022","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000025","properties":[{"key":"EntryName","value":"microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.58.60","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"16"}]},{"database":"Gene3D","id":"1.10.238.10","properties":[{"key":"EntryName","value":"EF-hand"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.920.20","properties":[{"key":"EntryName","value":"Gas2-like domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR011992","properties":[{"key":"EntryName","value":"EF-hand-dom_pair"}]},{"database":"InterPro","id":"IPR018247","properties":[{"key":"EntryName","value":"EF_Hand_1_Ca_BS"}]},{"database":"InterPro","id":"IPR002048","properties":[{"key":"EntryName","value":"EF_hand_dom"}]},{"database":"InterPro","id":"IPR003108","properties":[{"key":"EntryName","value":"GAR_dom"}]},{"database":"InterPro","id":"IPR036534","properties":[{"key":"EntryName","value":"GAR_dom_sf"}]},{"database":"InterPro","id":"IPR043197","properties":[{"key":"EntryName","value":"Plakin"}]},{"database":"InterPro","id":"IPR018159","properties":[{"key":"EntryName","value":"Spectrin/alpha-actinin"}]},{"database":"InterPro","id":"IPR002017","properties":[{"key":"EntryName","value":"Spectrin_repeat"}]},{"database":"PANTHER","id":"PTHR23169:SF24","properties":[{"key":"EntryName","value":"DYSTONIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR23169","properties":[{"key":"EntryName","value":"ENVOPLAKIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF13499","properties":[{"key":"EntryName","value":"EF-hand_7"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02187","properties":[{"key":"EntryName","value":"GAS2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00435","properties":[{"key":"EntryName","value":"Spectrin"},{"key":"MatchStatus","value":"13"}]},{"database":"SMART","id":"SM00054","properties":[{"key":"EntryName","value":"EFh"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00243","properties":[{"key":"EntryName","value":"GAS2"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00150","properties":[{"key":"EntryName","value":"SPEC"},{"key":"MatchStatus","value":"17"}]},{"database":"SUPFAM","id":"SSF47473","properties":[{"key":"EntryName","value":"EF-hand"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF143575","properties":[{"key":"EntryName","value":"GAS2 domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF46966","properties":[{"key":"EntryName","value":"Spectrin repeat"},{"key":"MatchStatus","value":"12"}]},{"database":"PROSITE","id":"PS00018","properties":[{"key":"EntryName","value":"EF_HAND_1"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS50222","properties":[{"key":"EntryName","value":"EF_HAND_2"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS51460","properties":[{"key":"EntryName","value":"GAR"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGKPLSRPDCLRQNPPCVGKGEEEEDLNIEDCYVPQRSIYDTVRLNEQIDSGSKGSLSSRHFTDRTLPYSHRTLDVSSLCSNGALTSSSVFELRGREANKLDEKMIFDALKLNSDIIRTTGLPKAKSHAEKKEHRRSWRMFVPANFMDYANKSESSFVEPADMSDAVTKASKCRWGTNSLTSEEDDSGLCSPPAEREEKQGILTGDQSRIKSLSSTEDILVTDQYRPFFSVNSISEQKIPLLSCQSAHPDENFKMILHDVSPLEEAKHVNGQREIHDENCCLQNNLKESPVKCDPLIMPRNRENEHIFNLGEEDETYGPGESQITAQSRELLKDSPQDLDLSHTDLGESDVDCGSTSLVENVTLLTQYDSGECNIASKEEVEAPLSAQESEMLYKKFSLKFVSARKKAAPRKTGAQAGILDTVCNGFQLVQVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAALHPNKDAYKPITDADKIEDEVTRQVAKCKCAKRFQVEQIGDNKYRFFLGNQFGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCRVHHHGSKMLRSESNSSITTTQPTIAKGRTNMELREKFILADGASQGMAAFRPRGRRSRPSSRGASPNRSTSVSSQAAQAASPQVPATTTPKGTPIQGSKLRLPGYLSGKGFHSGEDSGLITTAAARVRTQFADSKKTPSRPGSRAGSKAGSRASSRRGSDASDFDISEIQSVCSDVETVPQTHRPTPRAGSRPSTAKPSKIPTPQRKSPASKLDKSSKR","length":2676,"molWeight":304562,"crc64":"C2EF8336D5822174","md5":"8B6677C15498C4E66050705F3CA859A9"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Domain":3,"Region":5,"Coiled coil":4,"Compositional bias":4},"uniParcId":"UPI00108FF2BD"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A494C1D7","uniProtkbId":"A0A494C1D7_HUMAN","entryAudit":{"firstPublicDate":"2019-06-05","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2019-06-05","entryVersion":38,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000498983.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000498983.1"}],"value":"Dystonin"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000498983.1"}],"value":"DST"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004316"}],"value":"Cell projection","id":"SL-0280"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004245"}],"value":"Cytoplasm, cytoskeleton","id":"SL-0090"}}]}],"features":[{"type":"Domain","location":{"start":{"value":267,"modifier":"EXACT"},"end":{"value":371,"modifier":"EXACT"}},"description":"Calponin-homology (CH)","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50021"}]},{"type":"Domain","location":{"start":{"value":1003,"modifier":"EXACT"},"end":{"value":1060,"modifier":"EXACT"}},"description":"SH3","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50002"}]},{"type":"Region","location":{"start":{"value":11,"modifier":"EXACT"},"end":{"value":85,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":116,"modifier":"EXACT"},"end":{"value":143,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":194,"modifier":"EXACT"},"end":{"value":215,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":850,"modifier":"EXACT"},"end":{"value":884,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":1324,"modifier":"EXACT"},"end":{"value":1358,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":1534,"modifier":"EXACT"},"end":{"value":1564,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":1620,"modifier":"EXACT"},"end":{"value":1647,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":1753,"modifier":"EXACT"},"end":{"value":1787,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":1969,"modifier":"EXACT"},"end":{"value":1996,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Compositional bias","location":{"start":{"value":116,"modifier":"EXACT"},"end":{"value":128,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":129,"modifier":"EXACT"},"end":{"value":143,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":194,"modifier":"EXACT"},"end":{"value":206,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":2383,"modifier":"EXACT"},"end":{"value":2383,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000498983.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023203"}],"id":"KW-0009","category":"Molecular function","name":"Actin-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023273"}],"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023212"}],"id":"KW-0206","category":"Cellular component","name":"Cytoskeleton"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0A494C1D7"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0A494C1D7"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022443"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00192"}],"id":"KW-0728","category":"Domain","name":"SH3 domain"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000498983.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"14574404","citationType":"journal article","authors":["Mungall A.J.","Palmer S.A.","Sims S.K.","Edwards C.A.","Ashurst J.L.","Wilming L.","Jones M.C.","Horton R.","Hunt S.E.","Scott C.E.","Gilbert J.G.","Clamp M.E.","Bethel G.","Milne S.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Andrews T.D.","Ashwell R.I.","Babbage A.K.","Bagguley C.L.","Bailey J.","Banerjee R.","Barker D.J.","Barlow K.F.","Bates K.","Beare D.M.","Beasley H.","Beasley O.","Bird C.P.","Blakey S.","Bray-Allen S.","Brook J.","Brown A.J.","Brown J.Y.","Burford D.C.","Burrill W.","Burton J.","Carder C.","Carter N.P.","Chapman J.C.","Clark S.Y.","Clark G.","Clee C.M.","Clegg S.","Cobley V.","Collier R.E.","Collins J.E.","Colman L.K.","Corby N.R.","Coville G.J.","Culley K.M.","Dhami P.","Davies J.","Dunn M.","Earthrowl M.E.","Ellington A.E.","Evans K.A.","Faulkner L.","Francis M.D.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Ghori M.J.","Gilby L.M.","Gillson C.J.","Glithero R.J.","Grafham D.V.","Grant M.","Gribble S.","Griffiths C.","Griffiths M.","Hall R.","Halls K.S.","Hammond S.","Harley J.L.","Hart E.A.","Heath P.D.","Heathcott R.","Holmes S.J.","Howden P.J.","Howe K.L.","Howell G.R.","Huckle E.","Humphray S.J.","Humphries M.D.","Hunt A.R.","Johnson C.M.","Joy A.A.","Kay M.","Keenan S.J.","Kimberley A.M.","King A.","Laird G.K.","Langford C.","Lawlor S.","Leongamornlert D.A.","Leversha M.","Lloyd C.R.","Lloyd D.M.","Loveland J.E.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","Maslen G.L.","Matthews L.","McCann O.T.","McLaren S.J.","McLay K.","McMurray A.","Moore M.J.","Mullikin J.C.","Niblett D.","Nickerson T.","Novik K.L.","Oliver K.","Overton-Larty E.K.","Parker A.","Patel R.","Pearce A.V.","Peck A.I.","Phillimore B.","Phillips S.","Plumb R.W.","Porter K.M.","Ramsey Y.","Ranby S.A.","Rice C.M.","Ross M.T.","Searle S.M.","Sehra H.K.","Sheridan E.","Skuce C.D.","Smith S.","Smith M.","Spraggon L.","Squares S.L.","Steward C.A.","Sycamore N.","Tamlyn-Hall G.","Tester J.","Theaker A.J.","Thomas D.W.","Thorpe A.","Tracey A.","Tromans A.","Tubby B.","Wall M.","Wallis J.M.","West A.P.","White S.S.","Whitehead S.L.","Whittaker H.","Wild A.","Willey D.J.","Wilmer T.E.","Wood J.M.","Wray P.W.","Wyatt J.C.","Young L.","Younger R.M.","Bentley D.R.","Coulson A.","Durbin R.","Hubbard T.","Sulston J.E.","Dunham I.","Rogers J.","Beck S."],"citationCrossReferences":[{"database":"PubMed","id":"14574404"},{"database":"DOI","id":"10.1038/nature02055"}],"title":"The DNA sequence and analysis of human chromosome 6.","publicationDate":"2003","journal":"Nature","firstPage":"805","lastPage":"811","volume":"425"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000498983.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000498983.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000498983.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL096710","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL137008","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL512422","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL512448","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL590005","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL590037","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"KF458172","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"SMR","id":"A0A494C1D7","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"A0A494C1D7","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"31066","properties":[{"key":"antibodies","value":"185 antibodies from 24 providers"}]},{"database":"Ensembl","id":"ENST00000652573.1","properties":[{"key":"ProteinId","value":"ENSP00000498983.1"},{"key":"GeneId","value":"ENSG00000151914.22"}]},{"database":"HGNC","id":"HGNC:1090","properties":[{"key":"GeneName","value":"DST"}]},{"database":"OpenTargets","id":"ENSG00000151914","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000151914","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000155008","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"9479997at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"DST","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 6"}]},{"database":"Bgee","id":"ENSG00000151914","properties":[{"key":"ExpressionPatterns","value":"Expressed in corpus callosum and 207 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"A0A494C1D7","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005856","properties":[{"key":"GoTerm","value":"C:cytoskeleton"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0045104","properties":[{"key":"GoTerm","value":"P:intermediate filament cytoskeleton organization"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd21239","properties":[{"key":"EntryName","value":"CH_DYST_rpt2"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd00176","properties":[{"key":"EntryName","value":"SPEC"},{"key":"MatchStatus","value":"3"}]},{"database":"FunFam","id":"1.20.58.60:FF:000009","properties":[{"key":"EntryName","value":"dystonin isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000111","properties":[{"key":"EntryName","value":"dystonin isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000052","properties":[{"key":"EntryName","value":"dystonin isoform X2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000060","properties":[{"key":"EntryName","value":"dystonin isoform X2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000085","properties":[{"key":"EntryName","value":"dystonin isoform X2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000098","properties":[{"key":"EntryName","value":"dystonin isoform X3"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.418.10:FF:000002","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000027","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.30.30.40:FF:000011","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000010","properties":[{"key":"EntryName","value":"plectin isoform X2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.58.1060","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.58.60","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"9"}]},{"database":"Gene3D","id":"1.10.418.10","properties":[{"key":"EntryName","value":"Calponin-like domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.30.30.40","properties":[{"key":"EntryName","value":"SH3 Domains"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001715","properties":[{"key":"EntryName","value":"CH_dom"}]},{"database":"InterPro","id":"IPR036872","properties":[{"key":"EntryName","value":"CH_dom_sf"}]},{"database":"InterPro","id":"IPR041615","properties":[{"key":"EntryName","value":"Desmoplakin_SH3"}]},{"database":"InterPro","id":"IPR041573","properties":[{"key":"EntryName","value":"Desmoplakin_Spectrin-like"}]},{"database":"InterPro","id":"IPR049538","properties":[{"key":"EntryName","value":"PCN-like_spectrin-like_rpt"}]},{"database":"InterPro","id":"IPR043197","properties":[{"key":"EntryName","value":"Plakin"}]},{"database":"InterPro","id":"IPR001452","properties":[{"key":"EntryName","value":"SH3_domain"}]},{"database":"InterPro","id":"IPR018159","properties":[{"key":"EntryName","value":"Spectrin/alpha-actinin"}]},{"database":"InterPro","id":"IPR002017","properties":[{"key":"EntryName","value":"Spectrin_repeat"}]},{"database":"PANTHER","id":"PTHR23169:SF24","properties":[{"key":"EntryName","value":"DYSTONIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR23169","properties":[{"key":"EntryName","value":"ENVOPLAKIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00307","properties":[{"key":"EntryName","value":"CH"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF17902","properties":[{"key":"EntryName","value":"SH3_10"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00435","properties":[{"key":"EntryName","value":"Spectrin"},{"key":"MatchStatus","value":"4"}]},{"database":"Pfam","id":"PF18373","properties":[{"key":"EntryName","value":"Spectrin_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF21019","properties":[{"key":"EntryName","value":"Spectrin_3"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF21020","properties":[{"key":"EntryName","value":"Spectrin_4"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF27015","properties":[{"key":"EntryName","value":"SR_desmoplakin_3"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF21097","properties":[{"key":"EntryName","value":"SR_plectin_7"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00033","properties":[{"key":"EntryName","value":"CH"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00150","properties":[{"key":"EntryName","value":"SPEC"},{"key":"MatchStatus","value":"7"}]},{"database":"SUPFAM","id":"SSF47576","properties":[{"key":"EntryName","value":"Calponin-homology domain, CH-domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF46966","properties":[{"key":"EntryName","value":"Spectrin repeat"},{"key":"MatchStatus","value":"9"}]},{"database":"PROSITE","id":"PS50021","properties":[{"key":"EntryName","value":"CH"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50002","properties":[{"key":"EntryName","value":"SH3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGNVCGCVRAEKEEQYVDPAKTPLNPEKYSPGRKYFRRKPIKKTGGDKESVGANNENEGKKKSSSQPSKEQPAPLSRGLVQQESVTLNSALGDGIQQKKTEVVADSVKQKLLPSAVSSWSDCVNTSPAKDSETEVKVSELDERISEKDSTPYCAKRKKHLDDVNTSEITFQEKTDVFSFRKAASLSSIPSGIERSLEKSGFPEDPPKSYSSIQEKQNTERFCPHATQHFQFKKKRCHSLYTSMSSVSKDTDGNEISDIHVTGESEDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLANLEHAFYVAEKIGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPEGGEGIGANDVEVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKETEIPPKETEKSKIKRLYKLLEIWIEFGRIKLLQGYHPNDIEKEWGKLIIAMLEREKALRPEVERLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISGITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPSGLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKF","length":2383,"molWeight":273039,"crc64":"F470423A58B40530","md5":"688100296832AE9CCB09B3151D6EF262"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Domain":2,"Region":3,"Coiled coil":6,"Compositional bias":3,"Non-terminal residue":1},"uniParcId":"UPI00108D1893"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"E7ERX3","uniProtkbId":"E7ERX3_HUMAN","entryAudit":{"firstPublicDate":"2011-03-08","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-03-08","entryVersion":86,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000429221.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000429221.1"}],"value":"Dystonin"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000429221.1"}],"value":"DST"}}],"features":[{"type":"Domain","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":131,"modifier":"EXACT"}},"description":"Calponin-homology (CH)","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50021"}]},{"type":"Non-terminal residue","location":{"start":{"value":154,"modifier":"EXACT"},"end":{"value":154,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000429221.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023203"}],"id":"KW-0009","category":"Molecular function","name":"Actin-binding"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"E7ERX3"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"E7ERX3"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000429221.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"14574404","citationType":"journal article","authors":["Mungall A.J.","Palmer S.A.","Sims S.K.","Edwards C.A.","Ashurst J.L.","Wilming L.","Jones M.C.","Horton R.","Hunt S.E.","Scott C.E.","Gilbert J.G.","Clamp M.E.","Bethel G.","Milne S.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Andrews T.D.","Ashwell R.I.","Babbage A.K.","Bagguley C.L.","Bailey J.","Banerjee R.","Barker D.J.","Barlow K.F.","Bates K.","Beare D.M.","Beasley H.","Beasley O.","Bird C.P.","Blakey S.","Bray-Allen S.","Brook J.","Brown A.J.","Brown J.Y.","Burford D.C.","Burrill W.","Burton J.","Carder C.","Carter N.P.","Chapman J.C.","Clark S.Y.","Clark G.","Clee C.M.","Clegg S.","Cobley V.","Collier R.E.","Collins J.E.","Colman L.K.","Corby N.R.","Coville G.J.","Culley K.M.","Dhami P.","Davies J.","Dunn M.","Earthrowl M.E.","Ellington A.E.","Evans K.A.","Faulkner L.","Francis M.D.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Ghori M.J.","Gilby L.M.","Gillson C.J.","Glithero R.J.","Grafham D.V.","Grant M.","Gribble S.","Griffiths C.","Griffiths M.","Hall R.","Halls K.S.","Hammond S.","Harley J.L.","Hart E.A.","Heath P.D.","Heathcott R.","Holmes S.J.","Howden P.J.","Howe K.L.","Howell G.R.","Huckle E.","Humphray S.J.","Humphries M.D.","Hunt A.R.","Johnson C.M.","Joy A.A.","Kay M.","Keenan S.J.","Kimberley A.M.","King A.","Laird G.K.","Langford C.","Lawlor S.","Leongamornlert D.A.","Leversha M.","Lloyd C.R.","Lloyd D.M.","Loveland J.E.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","Maslen G.L.","Matthews L.","McCann O.T.","McLaren S.J.","McLay K.","McMurray A.","Moore M.J.","Mullikin J.C.","Niblett D.","Nickerson T.","Novik K.L.","Oliver K.","Overton-Larty E.K.","Parker A.","Patel R.","Pearce A.V.","Peck A.I.","Phillimore B.","Phillips S.","Plumb R.W.","Porter K.M.","Ramsey Y.","Ranby S.A.","Rice C.M.","Ross M.T.","Searle S.M.","Sehra H.K.","Sheridan E.","Skuce C.D.","Smith S.","Smith M.","Spraggon L.","Squares S.L.","Steward C.A.","Sycamore N.","Tamlyn-Hall G.","Tester J.","Theaker A.J.","Thomas D.W.","Thorpe A.","Tracey A.","Tromans A.","Tubby B.","Wall M.","Wallis J.M.","West A.P.","White S.S.","Whitehead S.L.","Whittaker H.","Wild A.","Willey D.J.","Wilmer T.E.","Wood J.M.","Wray P.W.","Wyatt J.C.","Young L.","Younger R.M.","Bentley D.R.","Coulson A.","Durbin R.","Hubbard T.","Sulston J.E.","Dunham I.","Rogers J.","Beck S."],"citationCrossReferences":[{"database":"PubMed","id":"14574404"},{"database":"DOI","id":"10.1038/nature02055"}],"title":"The DNA sequence and analysis of human chromosome 6.","publicationDate":"2003","journal":"Nature","firstPage":"805","lastPage":"811","volume":"425"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000429221.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000429221.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000429221.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL096710","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL137008","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL512422","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL512448","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL590005","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL590037","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"KF458172","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"E7ERX3","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"E7ERX3","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"E7ERX3","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"17872","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"31066","properties":[{"key":"antibodies","value":"185 antibodies from 24 providers"}]},{"database":"Ensembl","id":"ENST00000523817.1","properties":[{"key":"ProteinId","value":"ENSP00000429221.1"},{"key":"GeneId","value":"ENSG00000151914.22"}]},{"database":"UCSC","id":"uc063pfj.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:1090","properties":[{"key":"GeneName","value":"DST"}]},{"database":"OpenTargets","id":"ENSG00000151914","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000151914","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000155008","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_005217_2_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"9479997at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"DST","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 6"}]},{"database":"Bgee","id":"ENSG00000151914","properties":[{"key":"ExpressionPatterns","value":"Expressed in corpus callosum and 207 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"E7ERX3","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"FunFam","id":"1.10.418.10:FF:000017","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.418.10","properties":[{"key":"EntryName","value":"Calponin-like domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001589","properties":[{"key":"EntryName","value":"Actinin_actin-bd_CS"}]},{"database":"InterPro","id":"IPR001715","properties":[{"key":"EntryName","value":"CH_dom"}]},{"database":"InterPro","id":"IPR036872","properties":[{"key":"EntryName","value":"CH_dom_sf"}]},{"database":"PANTHER","id":"PTHR11915","properties":[{"key":"EntryName","value":"SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00307","properties":[{"key":"EntryName","value":"CH"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00033","properties":[{"key":"EntryName","value":"CH"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF47576","properties":[{"key":"EntryName","value":"Calponin-homology domain, CH-domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00019","properties":[{"key":"EntryName","value":"ACTININ_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00020","properties":[{"key":"EntryName","value":"ACTININ_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50021","properties":[{"key":"EntryName","value":"CH"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MMGQLMKNDQDWNAKLVGLMCCMDERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPREKGRMRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGESEDMSAKERLLLWT","length":154,"molWeight":18182,"crc64":"07CD0F6608C4805F","md5":"1C5202A486F7A907E84D43E8F26AB785"},"extraAttributes":{"countByFeatureType":{"Domain":1,"Non-terminal residue":1},"uniParcId":"UPI0001E8F3D2"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q9BSP9","uniProtkbId":"Q9BSP9_HUMAN","entryAudit":{"firstPublicDate":"2001-06-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2004-03-01","entryVersion":97,"sequenceVersion":2},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAH04912.2"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAH04912.2"}],"value":"DST protein"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAH04912.2"}],"value":"DST"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004245"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00792"}],"value":"Cytoplasm, cytoskeleton","id":"SL-0090"}}]}],"features":[{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":63,"modifier":"EXACT"}},"description":"GAR","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51460"}]},{"type":"Region","location":{"start":{"value":83,"modifier":"EXACT"},"end":{"value":140,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":169,"modifier":"EXACT"},"end":{"value":258,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":99,"modifier":"EXACT"},"end":{"value":129,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":178,"modifier":"EXACT"},"end":{"value":192,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":207,"modifier":"EXACT"},"end":{"value":223,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAH04912.2"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00792"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023212"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00792"}],"id":"KW-0206","category":"Cellular component","name":"Cytoskeleton"}],"references":[{"referenceNumber":1,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"authors":["Gerhard D.S.","Wagner L.","Feingold E.A.","Shenmen C.M.","Grouse L.H.","Schuler G.","Klein S.L.","Old S.","Rasooly R.","Good P.","Guyer M.","Peck A.M.","Derge J.G.","Lipman D.","Collins F.S.","Jang W.","Sherry S.","Feolo M.","Misquitta L.","Lee E.","Rotmistrovsky K.","Greenhut S.F.","Schaefer C.F.","Buetow K.","Bonner T.I.","Haussler D.","Kent J.","Kiekhaus M.","Furey T.","Brent M.","Prange C.","Schreiber K.","Shapiro N.","Bhat N.K.","Hopkins R.F.","Hsie F.","Driscoll T.","Soares M.B.","Casavant T.L.","Scheetz T.E.","Brown-stein M.J.","Usdin T.B.","Toshiyuki S.","Carninci P.","Piao Y.","Dudekula D.B.","Ko M.S.","Kawakami K.","Suzuki Y.","Sugano S.","Gruber C.E.","Smith M.R.","Simmons B.","Moore T.","Waterman R.","Johnson S.L.","Ruan Y.","Wei C.L.","Mathavan S.","Gunaratne P.H.","Wu J.","Garcia A.M.","Hulyk S.W.","Fuh E.","Yuan Y.","Sneed A.","Kowis C.","Hodgson A.","Muzny D.M.","McPherson J.","Gibbs R.A.","Fahey J.","Helton E.","Ketteman M.","Madan A.","Rodrigues S.","Sanchez A.","Whiting M.","Madari A.","Young A.C.","Wetherby K.D.","Granite S.J.","Kwong P.N.","Brinkley C.P.","Pearson R.L.","Bouffard G.G.","Blakesly R.W.","Green E.D.","Dickson M.C.","Rodriguez A.C.","Grimwood J.","Schmutz J.","Myers R.M.","Butterfield Y.S.","Griffith M.","Griffith O.L.","Krzywinski M.I.","Liao N.","Morin R.","Morrin R.","Palmquist D.","Petrescu A.S.","Skalska U.","Smailus D.E.","Stott J.M.","Schnerch A.","Schein J.E.","Jones S.J.","Holt R.A.","Baross A.","Marra M.A.","Clifton S.","Makowski K.A.","Bosak S.","Malek J."],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAH04912.2"}],"value":"Lung","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAH04912.2"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"BC004912","properties":[{"key":"ProteinId","value":"AAH04912.2"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"Q9BSP9","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"9479997at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"DST","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GO","id":"GO:0005856","properties":[{"key":"GoTerm","value":"C:cytoskeleton"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0008017","properties":[{"key":"GoTerm","value":"F:microtubule binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"FunFam","id":"3.30.920.20:FF:000001","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.920.20","properties":[{"key":"EntryName","value":"Gas2-like domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR003108","properties":[{"key":"EntryName","value":"GAR_dom"}]},{"database":"InterPro","id":"IPR036534","properties":[{"key":"EntryName","value":"GAR_dom_sf"}]},{"database":"PANTHER","id":"PTHR46756:SF18","properties":[{"key":"EntryName","value":"GAS2-LIKE PROTEIN PICKLED EGGS"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46756","properties":[{"key":"EntryName","value":"TRANSGELIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02187","properties":[{"key":"EntryName","value":"GAS2"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00243","properties":[{"key":"EntryName","value":"GAS2"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF143575","properties":[{"key":"EntryName","value":"GAS2 domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51460","properties":[{"key":"EntryName","value":"GAR"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"TRQVAKCKCAKRFQVEQIGDNKYRFGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCRAKGRTNMELREKFILADGASQGMAAFRPRGRRSRPSSRGASPNRSTSVSSQAAQAASPQVPATTTPKGTPIQGSKLRLPGYLSGKGFHSGEDSGLITTAAARVRTQFADSKKTPSRPGSRAGSKAGSRASSRRGSDASDFDISEIQSVCSDVETVPQTHRPTPRAGSRPSTAKPSKIPTPQRKSPASKLDKSSKR","length":258,"molWeight":27771,"crc64":"AA3A5AFFC78EF1C2","md5":"0BAF4380E45B76CF3F4335E698B80710"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Domain":1,"Region":2,"Compositional bias":3,"Non-terminal residue":1},"uniParcId":"UPI0000213ECB"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"H0YBX0","uniProtkbId":"H0YBX0_HUMAN","entryAudit":{"firstPublicDate":"2012-02-22","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2012-02-22","entryVersion":74,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000430472.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000430472.1"}],"value":"Dystonin"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000430472.1"}],"value":"DST"}}],"features":[{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":28,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":13,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000430472.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"H0YBX0"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"H0YBX0"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000430472.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"14574404","citationType":"journal article","authors":["Mungall A.J.","Palmer S.A.","Sims S.K.","Edwards C.A.","Ashurst J.L.","Wilming L.","Jones M.C.","Horton R.","Hunt S.E.","Scott C.E.","Gilbert J.G.","Clamp M.E.","Bethel G.","Milne S.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Andrews T.D.","Ashwell R.I.","Babbage A.K.","Bagguley C.L.","Bailey J.","Banerjee R.","Barker D.J.","Barlow K.F.","Bates K.","Beare D.M.","Beasley H.","Beasley O.","Bird C.P.","Blakey S.","Bray-Allen S.","Brook J.","Brown A.J.","Brown J.Y.","Burford D.C.","Burrill W.","Burton J.","Carder C.","Carter N.P.","Chapman J.C.","Clark S.Y.","Clark G.","Clee C.M.","Clegg S.","Cobley V.","Collier R.E.","Collins J.E.","Colman L.K.","Corby N.R.","Coville G.J.","Culley K.M.","Dhami P.","Davies J.","Dunn M.","Earthrowl M.E.","Ellington A.E.","Evans K.A.","Faulkner L.","Francis M.D.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Ghori M.J.","Gilby L.M.","Gillson C.J.","Glithero R.J.","Grafham D.V.","Grant M.","Gribble S.","Griffiths C.","Griffiths M.","Hall R.","Halls K.S.","Hammond S.","Harley J.L.","Hart E.A.","Heath P.D.","Heathcott R.","Holmes S.J.","Howden P.J.","Howe K.L.","Howell G.R.","Huckle E.","Humphray S.J.","Humphries M.D.","Hunt A.R.","Johnson C.M.","Joy A.A.","Kay M.","Keenan S.J.","Kimberley A.M.","King A.","Laird G.K.","Langford C.","Lawlor S.","Leongamornlert D.A.","Leversha M.","Lloyd C.R.","Lloyd D.M.","Loveland J.E.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","Maslen G.L.","Matthews L.","McCann O.T.","McLaren S.J.","McLay K.","McMurray A.","Moore M.J.","Mullikin J.C.","Niblett D.","Nickerson T.","Novik K.L.","Oliver K.","Overton-Larty E.K.","Parker A.","Patel R.","Pearce A.V.","Peck A.I.","Phillimore B.","Phillips S.","Plumb R.W.","Porter K.M.","Ramsey Y.","Ranby S.A.","Rice C.M.","Ross M.T.","Searle S.M.","Sehra H.K.","Sheridan E.","Skuce C.D.","Smith S.","Smith M.","Spraggon L.","Squares S.L.","Steward C.A.","Sycamore N.","Tamlyn-Hall G.","Tester J.","Theaker A.J.","Thomas D.W.","Thorpe A.","Tracey A.","Tromans A.","Tubby B.","Wall M.","Wallis J.M.","West A.P.","White S.S.","Whitehead S.L.","Whittaker H.","Wild A.","Willey D.J.","Wilmer T.E.","Wood J.M.","Wray P.W.","Wyatt J.C.","Young L.","Younger R.M.","Bentley D.R.","Coulson A.","Durbin R.","Hubbard T.","Sulston J.E.","Dunham I.","Rogers J.","Beck S."],"citationCrossReferences":[{"database":"PubMed","id":"14574404"},{"database":"DOI","id":"10.1038/nature02055"}],"title":"The DNA sequence and analysis of human chromosome 6.","publicationDate":"2003","journal":"Nature","firstPage":"805","lastPage":"811","volume":"425"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000430472.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000430472.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000430472.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL096710","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL137008","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL512422","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL512448","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL590005","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL590037","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"KF458172","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"H0YBX0","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"H0YBX0","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"H0YBX0","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"36866","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"31066","properties":[{"key":"antibodies","value":"185 antibodies from 24 providers"}]},{"database":"Ensembl","id":"ENST00000523943.1","properties":[{"key":"ProteinId","value":"ENSP00000430472.1"},{"key":"GeneId","value":"ENSG00000151914.22"}]},{"database":"UCSC","id":"uc063pet.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:1090","properties":[{"key":"GeneName","value":"DST"}]},{"database":"OpenTargets","id":"ENSG00000151914","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000151914","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000155008","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_2020474_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"9479997at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"DST","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 6"}]},{"database":"Bgee","id":"ENSG00000151914","properties":[{"key":"ExpressionPatterns","value":"Expressed in corpus callosum and 207 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"H0YBX0","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"Gene3D","id":"1.20.58.60","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"EMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEEVWKFIPSTPHCHLPSFLITHCHCQNLGIF","length":123,"molWeight":14258,"crc64":"35DFB00E62BDA841","md5":"B6EE97EBDD3D370989C363101FF21CB7"},"extraAttributes":{"countByFeatureType":{"Region":1,"Compositional bias":1,"Non-terminal residue":1},"uniParcId":"UPI0001E8F3CE"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"H0YC65","uniProtkbId":"H0YC65_HUMAN","entryAudit":{"firstPublicDate":"2012-02-22","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":83,"sequenceVersion":3},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000431020.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000431020.1"}],"value":"Dystonin"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000431020.1"}],"value":"DST"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004245"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00792"}],"value":"Cytoplasm, cytoskeleton","id":"SL-0090"}}]}],"features":[{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":64,"modifier":"EXACT"}},"description":"GAR","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51460"}]},{"type":"Region","location":{"start":{"value":84,"modifier":"EXACT"},"end":{"value":141,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":170,"modifier":"EXACT"},"end":{"value":259,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":100,"modifier":"EXACT"},"end":{"value":130,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":179,"modifier":"EXACT"},"end":{"value":193,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":208,"modifier":"EXACT"},"end":{"value":224,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000431020.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00792"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023212"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00792"}],"id":"KW-0206","category":"Cellular component","name":"Cytoskeleton"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"H0YC65"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"H0YC65"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000431020.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"14574404","citationType":"journal article","authors":["Mungall A.J.","Palmer S.A.","Sims S.K.","Edwards C.A.","Ashurst J.L.","Wilming L.","Jones M.C.","Horton R.","Hunt S.E.","Scott C.E.","Gilbert J.G.","Clamp M.E.","Bethel G.","Milne S.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Andrews T.D.","Ashwell R.I.","Babbage A.K.","Bagguley C.L.","Bailey J.","Banerjee R.","Barker D.J.","Barlow K.F.","Bates K.","Beare D.M.","Beasley H.","Beasley O.","Bird C.P.","Blakey S.","Bray-Allen S.","Brook J.","Brown A.J.","Brown J.Y.","Burford D.C.","Burrill W.","Burton J.","Carder C.","Carter N.P.","Chapman J.C.","Clark S.Y.","Clark G.","Clee C.M.","Clegg S.","Cobley V.","Collier R.E.","Collins J.E.","Colman L.K.","Corby N.R.","Coville G.J.","Culley K.M.","Dhami P.","Davies J.","Dunn M.","Earthrowl M.E.","Ellington A.E.","Evans K.A.","Faulkner L.","Francis M.D.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Ghori M.J.","Gilby L.M.","Gillson C.J.","Glithero R.J.","Grafham D.V.","Grant M.","Gribble S.","Griffiths C.","Griffiths M.","Hall R.","Halls K.S.","Hammond S.","Harley J.L.","Hart E.A.","Heath P.D.","Heathcott R.","Holmes S.J.","Howden P.J.","Howe K.L.","Howell G.R.","Huckle E.","Humphray S.J.","Humphries M.D.","Hunt A.R.","Johnson C.M.","Joy A.A.","Kay M.","Keenan S.J.","Kimberley A.M.","King A.","Laird G.K.","Langford C.","Lawlor S.","Leongamornlert D.A.","Leversha M.","Lloyd C.R.","Lloyd D.M.","Loveland J.E.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","Maslen G.L.","Matthews L.","McCann O.T.","McLaren S.J.","McLay K.","McMurray A.","Moore M.J.","Mullikin J.C.","Niblett D.","Nickerson T.","Novik K.L.","Oliver K.","Overton-Larty E.K.","Parker A.","Patel R.","Pearce A.V.","Peck A.I.","Phillimore B.","Phillips S.","Plumb R.W.","Porter K.M.","Ramsey Y.","Ranby S.A.","Rice C.M.","Ross M.T.","Searle S.M.","Sehra H.K.","Sheridan E.","Skuce C.D.","Smith S.","Smith M.","Spraggon L.","Squares S.L.","Steward C.A.","Sycamore N.","Tamlyn-Hall G.","Tester J.","Theaker A.J.","Thomas D.W.","Thorpe A.","Tracey A.","Tromans A.","Tubby B.","Wall M.","Wallis J.M.","West A.P.","White S.S.","Whitehead S.L.","Whittaker H.","Wild A.","Willey D.J.","Wilmer T.E.","Wood J.M.","Wray P.W.","Wyatt J.C.","Young L.","Younger R.M.","Bentley D.R.","Coulson A.","Durbin R.","Hubbard T.","Sulston J.E.","Dunham I.","Rogers J.","Beck S."],"citationCrossReferences":[{"database":"PubMed","id":"14574404"},{"database":"DOI","id":"10.1038/nature02055"}],"title":"The DNA sequence and analysis of human chromosome 6.","publicationDate":"2003","journal":"Nature","firstPage":"805","lastPage":"811","volume":"425"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000431020.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000431020.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"18669648","citationType":"journal article","authors":["Dephoure N.","Zhou C.","Villen J.","Beausoleil S.A.","Bakalarski C.E.","Elledge S.J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"18669648"},{"database":"DOI","id":"10.1073/pnas.0805139105"}],"title":"A quantitative atlas of mitotic phosphorylation.","publicationDate":"2008","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10762","lastPage":"10767","volume":"105"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"18669648"}]},{"referenceNumber":5,"citation":{"id":"21406692","citationType":"journal article","authors":["Rigbolt K.T.","Prokhorova T.A.","Akimov V.","Henningsen J.","Johansen P.T.","Kratchmarova I.","Kassem M.","Mann M.","Olsen J.V.","Blagoev B."],"citationCrossReferences":[{"database":"PubMed","id":"21406692"},{"database":"DOI","id":"10.1126/scisignal.2001570"}],"title":"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.","publicationDate":"2011","journal":"Sci. Signal.","firstPage":"RS3","lastPage":"RS3","volume":"4"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"21406692"}]},{"referenceNumber":6,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000431020.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL096710","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL137008","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL512422","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL512448","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL590005","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL590037","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"KF458172","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"SMR","id":"H0YC65","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"H0YC65","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"36960","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"31066","properties":[{"key":"antibodies","value":"185 antibodies from 24 providers"}]},{"database":"Ensembl","id":"ENST00000523292.5","properties":[{"key":"ProteinId","value":"ENSP00000431020.1"},{"key":"GeneId","value":"ENSG00000151914.22"}]},{"database":"UCSC","id":"uc063pem.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:1090","properties":[{"key":"GeneName","value":"DST"}]},{"database":"OpenTargets","id":"ENSG00000151914","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000151914","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000155008","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_061491_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"9479997at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"DST","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 6"}]},{"database":"Bgee","id":"ENSG00000151914","properties":[{"key":"ExpressionPatterns","value":"Expressed in corpus callosum and 207 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"H0YC65","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005856","properties":[{"key":"GoTerm","value":"C:cytoskeleton"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0008017","properties":[{"key":"GoTerm","value":"F:microtubule binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"FunFam","id":"3.30.920.20:FF:000001","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.920.20","properties":[{"key":"EntryName","value":"Gas2-like domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR003108","properties":[{"key":"EntryName","value":"GAR_dom"}]},{"database":"InterPro","id":"IPR036534","properties":[{"key":"EntryName","value":"GAR_dom_sf"}]},{"database":"PANTHER","id":"PTHR46756:SF18","properties":[{"key":"EntryName","value":"GAS2-LIKE PROTEIN PICKLED EGGS"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46756","properties":[{"key":"EntryName","value":"TRANSGELIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02187","properties":[{"key":"EntryName","value":"GAS2"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00243","properties":[{"key":"EntryName","value":"GAS2"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF143575","properties":[{"key":"EntryName","value":"GAS2 domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51460","properties":[{"key":"EntryName","value":"GAR"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"XTRQVAKCKCAKRFQVEQIGDNKYRFGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCRAKGRTNMELREKFILADGASQGMAAFRPRGRRSRPSSRGASPNRSTSVSSQAAQAASPQVPATTTPKGTPIQGSKLRLPGYLSGKGFHSGEDSGLITTAAARVRTQFADSKKTPSRPGSRAGSKAGSRASSRRGSDASDFDISEIQSVCSDVETVPQTHRPTPRAGSRPSTAKPSKIPTPQRKSPASKLDKSSKR","length":259,"molWeight":27883,"crc64":"AA3A45CF478EC47A","md5":"5E309580A88E87D1A2DDCBEA6331C2A4"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Domain":1,"Region":2,"Compositional bias":3,"Non-terminal residue":1},"uniParcId":"UPI0001E8F3D0"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q86T18","uniProtkbId":"Q86T18_HUMAN","entryAudit":{"firstPublicDate":"2003-06-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2003-06-01","entryVersion":107,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAH51772.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAH51772.1"}],"value":"DST protein"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAH51772.1"}],"value":"DST"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004245"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00792"}],"value":"Cytoplasm, cytoskeleton","id":"SL-0090"}}]}],"features":[{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":26,"modifier":"EXACT"}},"description":"GAR","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51460"}]},{"type":"Region","location":{"start":{"value":46,"modifier":"EXACT"},"end":{"value":99,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":169,"modifier":"EXACT"},"end":{"value":258,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":62,"modifier":"EXACT"},"end":{"value":92,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":178,"modifier":"EXACT"},"end":{"value":192,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":207,"modifier":"EXACT"},"end":{"value":223,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAH51772.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00792"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023212"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00792"}],"id":"KW-0206","category":"Cellular component","name":"Cytoskeleton"}],"references":[{"referenceNumber":1,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"authors":["Gerhard D.S.","Wagner L.","Feingold E.A.","Shenmen C.M.","Grouse L.H.","Schuler G.","Klein S.L.","Old S.","Rasooly R.","Good P.","Guyer M.","Peck A.M.","Derge J.G.","Lipman D.","Collins F.S.","Jang W.","Sherry S.","Feolo M.","Misquitta L.","Lee E.","Rotmistrovsky K.","Greenhut S.F.","Schaefer C.F.","Buetow K.","Bonner T.I.","Haussler D.","Kent J.","Kiekhaus M.","Furey T.","Brent M.","Prange C.","Schreiber K.","Shapiro N.","Bhat N.K.","Hopkins R.F.","Hsie F.","Driscoll T.","Soares M.B.","Casavant T.L.","Scheetz T.E.","Brown-stein M.J.","Usdin T.B.","Toshiyuki S.","Carninci P.","Piao Y.","Dudekula D.B.","Ko M.S.","Kawakami K.","Suzuki Y.","Sugano S.","Gruber C.E.","Smith M.R.","Simmons B.","Moore T.","Waterman R.","Johnson S.L.","Ruan Y.","Wei C.L.","Mathavan S.","Gunaratne P.H.","Wu J.","Garcia A.M.","Hulyk S.W.","Fuh E.","Yuan Y.","Sneed A.","Kowis C.","Hodgson A.","Muzny D.M.","McPherson J.","Gibbs R.A.","Fahey J.","Helton E.","Ketteman M.","Madan A.","Rodrigues S.","Sanchez A.","Whiting M.","Madari A.","Young A.C.","Wetherby K.D.","Granite S.J.","Kwong P.N.","Brinkley C.P.","Pearson R.L.","Bouffard G.G.","Blakesly R.W.","Green E.D.","Dickson M.C.","Rodriguez A.C.","Grimwood J.","Schmutz J.","Myers R.M.","Butterfield Y.S.","Griffith M.","Griffith O.L.","Krzywinski M.I.","Liao N.","Morin R.","Morrin R.","Palmquist D.","Petrescu A.S.","Skalska U.","Smailus D.E.","Stott J.M.","Schnerch A.","Schein J.E.","Jones S.J.","Holt R.A.","Baross A.","Marra M.A.","Clifton S.","Makowski K.A.","Bosak S.","Malek J."],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAH51772.1"}],"value":"Peripheral Nervous System","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAH51772.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"BC051772","properties":[{"key":"ProteinId","value":"AAH51772.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"Q86T18","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q86T18","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"9479997at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"DST","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GO","id":"GO:0005856","properties":[{"key":"GoTerm","value":"C:cytoskeleton"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0008017","properties":[{"key":"GoTerm","value":"F:microtubule binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"3.30.920.20","properties":[{"key":"EntryName","value":"Gas2-like domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR003108","properties":[{"key":"EntryName","value":"GAR_dom"}]},{"database":"InterPro","id":"IPR036534","properties":[{"key":"EntryName","value":"GAR_dom_sf"}]},{"database":"PANTHER","id":"PTHR46756:SF18","properties":[{"key":"EntryName","value":"GAS2-LIKE PROTEIN PICKLED EGGS"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46756","properties":[{"key":"EntryName","value":"TRANSGELIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02187","properties":[{"key":"EntryName","value":"GAS2"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00243","properties":[{"key":"EntryName","value":"GAS2"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF143575","properties":[{"key":"EntryName","value":"GAS2 domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51460","properties":[{"key":"EntryName","value":"GAR"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"RSTVMVRVGGGWMALDEFLVKNDPCRAKGRTNMELREKFILADGASQGMAAFRPRGRRSRPSSRGASPNRSTSVSSQAAQAASPQVPATTTPKILHPLTRNYGKPWLTNSKMSTPCKAAECSDFPVPSAEGTPIQGSKLRLPGYLSGKGFHSGEDSGLITTAAARVRTQFADSKKTPSRPGSRAGSKAGSRASSRRGSDASDFDISEIQSVCSDVETVPQTHRPTPRAGSRPSTAKPSKIPTPQRKSPASKLDKSSKR","length":258,"molWeight":27465,"crc64":"7433E1AF263E4EAA","md5":"D35915DA8FF9FCE2C8F1C2CCE19875C6"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Domain":1,"Region":2,"Compositional bias":3,"Non-terminal residue":1},"uniParcId":"UPI000019A3BD"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q6P0N6","uniProtkbId":"Q6P0N6_HUMAN","entryAudit":{"firstPublicDate":"2004-07-05","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2004-07-05","entryVersion":164,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAH65536.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAH65536.1"}],"value":"DST protein"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAH65536.1"}],"value":"DST"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004316"}],"value":"Cell projection","id":"SL-0280"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004245"}],"value":"Cytoplasm, cytoskeleton","id":"SL-0090"}}]}],"features":[{"type":"Domain","location":{"start":{"value":561,"modifier":"EXACT"},"end":{"value":618,"modifier":"EXACT"}},"description":"SH3","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50002"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":23,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":408,"modifier":"EXACT"},"end":{"value":442,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":882,"modifier":"EXACT"},"end":{"value":916,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Compositional bias","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":16,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023273"}],"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023212"}],"id":"KW-0206","category":"Cellular component","name":"Cytoskeleton"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022443"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00192"}],"id":"KW-0728","category":"Domain","name":"SH3 domain"}],"references":[{"referenceNumber":1,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"authors":["Gerhard D.S.","Wagner L.","Feingold E.A.","Shenmen C.M.","Grouse L.H.","Schuler G.","Klein S.L.","Old S.","Rasooly R.","Good P.","Guyer M.","Peck A.M.","Derge J.G.","Lipman D.","Collins F.S.","Jang W.","Sherry S.","Feolo M.","Misquitta L.","Lee E.","Rotmistrovsky K.","Greenhut S.F.","Schaefer C.F.","Buetow K.","Bonner T.I.","Haussler D.","Kent J.","Kiekhaus M.","Furey T.","Brent M.","Prange C.","Schreiber K.","Shapiro N.","Bhat N.K.","Hopkins R.F.","Hsie F.","Driscoll T.","Soares M.B.","Casavant T.L.","Scheetz T.E.","Brown-stein M.J.","Usdin T.B.","Toshiyuki S.","Carninci P.","Piao Y.","Dudekula D.B.","Ko M.S.","Kawakami K.","Suzuki Y.","Sugano S.","Gruber C.E.","Smith M.R.","Simmons B.","Moore T.","Waterman R.","Johnson S.L.","Ruan Y.","Wei C.L.","Mathavan S.","Gunaratne P.H.","Wu J.","Garcia A.M.","Hulyk S.W.","Fuh E.","Yuan Y.","Sneed A.","Kowis C.","Hodgson A.","Muzny D.M.","McPherson J.","Gibbs R.A.","Fahey J.","Helton E.","Ketteman M.","Madan A.","Rodrigues S.","Sanchez A.","Whiting M.","Madari A.","Young A.C.","Wetherby K.D.","Granite S.J.","Kwong P.N.","Brinkley C.P.","Pearson R.L.","Bouffard G.G.","Blakesly R.W.","Green E.D.","Dickson M.C.","Rodriguez A.C.","Grimwood J.","Schmutz J.","Myers R.M.","Butterfield Y.S.","Griffith M.","Griffith O.L.","Krzywinski M.I.","Liao N.","Morin R.","Morrin R.","Palmquist D.","Petrescu A.S.","Skalska U.","Smailus D.E.","Stott J.M.","Schnerch A.","Schein J.E.","Jones S.J.","Holt R.A.","Baross A.","Marra M.A.","Clifton S.","Makowski K.A.","Bosak S.","Malek J."],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAH65536.1"}],"value":"Lung","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAH65536.1"}]},{"referenceNumber":2,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Burckstummer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"21269460"}]},{"referenceNumber":3,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"24275569"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"BC065536","properties":[{"key":"ProteinId","value":"AAH65536.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"RefSeq","id":"NP_001138241.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001144769.5"}]},{"database":"RefSeq","id":"NP_001138242.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001144770.2"}]},{"database":"RefSeq","id":"NP_899236.1","properties":[{"key":"NucleotideSequenceId","value":"NM_183380.4"}]},{"database":"AlphaFoldDB","id":"Q6P0N6","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q6P0N6","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"66815","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"31066","properties":[{"key":"antibodies","value":"185 antibodies from 24 providers"}]},{"database":"DNASU","id":"667","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"667","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc003pdd.6","properties":[{"key":"OrganismName","value":"human"}]},{"database":"CTD","id":"667","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"667","properties":[{"key":"Description","value":"-"}]},{"database":"OpenTargets","id":"ENSG00000151914","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000151914","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000155008","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"9479997at2759","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"667","properties":[{"key":"hits","value":"16 hits in 1162 CRISPR screens"}]},{"database":"ChiTaRS","id":"DST","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Bgee","id":"ENSG00000151914","properties":[{"key":"ExpressionPatterns","value":"Expressed in corpus callosum and 207 other cell types or tissues"}]},{"database":"GO","id":"GO:0005856","properties":[{"key":"GoTerm","value":"C:cytoskeleton"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0045104","properties":[{"key":"GoTerm","value":"P:intermediate filament cytoskeleton organization"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd00176","properties":[{"key":"EntryName","value":"SPEC"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000009","properties":[{"key":"EntryName","value":"dystonin isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000052","properties":[{"key":"EntryName","value":"dystonin isoform X2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000060","properties":[{"key":"EntryName","value":"dystonin isoform X2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.30.30.40:FF:000011","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000010","properties":[{"key":"EntryName","value":"plectin isoform X2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.58.1060","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.58.60","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"4"}]},{"database":"Gene3D","id":"2.30.30.40","properties":[{"key":"EntryName","value":"SH3 Domains"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR041615","properties":[{"key":"EntryName","value":"Desmoplakin_SH3"}]},{"database":"InterPro","id":"IPR041573","properties":[{"key":"EntryName","value":"Desmoplakin_Spectrin-like"}]},{"database":"InterPro","id":"IPR049538","properties":[{"key":"EntryName","value":"PCN-like_spectrin-like_rpt"}]},{"database":"InterPro","id":"IPR043197","properties":[{"key":"EntryName","value":"Plakin"}]},{"database":"InterPro","id":"IPR001452","properties":[{"key":"EntryName","value":"SH3_domain"}]},{"database":"InterPro","id":"IPR018159","properties":[{"key":"EntryName","value":"Spectrin/alpha-actinin"}]},{"database":"InterPro","id":"IPR002017","properties":[{"key":"EntryName","value":"Spectrin_repeat"}]},{"database":"PANTHER","id":"PTHR23169:SF24","properties":[{"key":"EntryName","value":"DYSTONIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR23169","properties":[{"key":"EntryName","value":"ENVOPLAKIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF17902","properties":[{"key":"EntryName","value":"SH3_10"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00435","properties":[{"key":"EntryName","value":"Spectrin"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF18373","properties":[{"key":"EntryName","value":"Spectrin_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF21019","properties":[{"key":"EntryName","value":"Spectrin_3"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF21020","properties":[{"key":"EntryName","value":"Spectrin_4"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF27015","properties":[{"key":"EntryName","value":"SR_desmoplakin_3"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF21097","properties":[{"key":"EntryName","value":"SR_plectin_7"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00150","properties":[{"key":"EntryName","value":"SPEC"},{"key":"MatchStatus","value":"3"}]},{"database":"SUPFAM","id":"SSF46966","properties":[{"key":"EntryName","value":"Spectrin repeat"},{"key":"MatchStatus","value":"4"}]},{"database":"PROSITE","id":"PS50002","properties":[{"key":"EntryName","value":"SH3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MHSSSYSYRSSDSVFSNTTSTRTSLDSNENLLLVHCGPTLINSCISFGSESFDGHRLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISGITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPSGLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEVIINSEHPVNIKELEMSSNYSVVWESKTCFMINLCGR","length":1143,"molWeight":132290,"crc64":"F4A7E9590A05067A","md5":"889004E7828F535686C2CC22107F7B8C"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Domain":1,"Region":1,"Coiled coil":2,"Compositional bias":1},"uniParcId":"UPI0000237C88"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"H0YC82","uniProtkbId":"H0YC82_HUMAN","entryAudit":{"firstPublicDate":"2012-02-22","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2012-02-22","entryVersion":71,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000431121.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000431121.1"}],"value":"Dystonin"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000431121.1"}],"value":"DST"}}],"features":[{"type":"Coiled coil","location":{"start":{"value":187,"modifier":"EXACT"},"end":{"value":214,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000431121.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023203"}],"id":"KW-0009","category":"Molecular function","name":"Actin-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"H0YC82"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"H0YC82"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000431121.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"14574404","citationType":"journal article","authors":["Mungall A.J.","Palmer S.A.","Sims S.K.","Edwards C.A.","Ashurst J.L.","Wilming L.","Jones M.C.","Horton R.","Hunt S.E.","Scott C.E.","Gilbert J.G.","Clamp M.E.","Bethel G.","Milne S.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Andrews T.D.","Ashwell R.I.","Babbage A.K.","Bagguley C.L.","Bailey J.","Banerjee R.","Barker D.J.","Barlow K.F.","Bates K.","Beare D.M.","Beasley H.","Beasley O.","Bird C.P.","Blakey S.","Bray-Allen S.","Brook J.","Brown A.J.","Brown J.Y.","Burford D.C.","Burrill W.","Burton J.","Carder C.","Carter N.P.","Chapman J.C.","Clark S.Y.","Clark G.","Clee C.M.","Clegg S.","Cobley V.","Collier R.E.","Collins J.E.","Colman L.K.","Corby N.R.","Coville G.J.","Culley K.M.","Dhami P.","Davies J.","Dunn M.","Earthrowl M.E.","Ellington A.E.","Evans K.A.","Faulkner L.","Francis M.D.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Ghori M.J.","Gilby L.M.","Gillson C.J.","Glithero R.J.","Grafham D.V.","Grant M.","Gribble S.","Griffiths C.","Griffiths M.","Hall R.","Halls K.S.","Hammond S.","Harley J.L.","Hart E.A.","Heath P.D.","Heathcott R.","Holmes S.J.","Howden P.J.","Howe K.L.","Howell G.R.","Huckle E.","Humphray S.J.","Humphries M.D.","Hunt A.R.","Johnson C.M.","Joy A.A.","Kay M.","Keenan S.J.","Kimberley A.M.","King A.","Laird G.K.","Langford C.","Lawlor S.","Leongamornlert D.A.","Leversha M.","Lloyd C.R.","Lloyd D.M.","Loveland J.E.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","Maslen G.L.","Matthews L.","McCann O.T.","McLaren S.J.","McLay K.","McMurray A.","Moore M.J.","Mullikin J.C.","Niblett D.","Nickerson T.","Novik K.L.","Oliver K.","Overton-Larty E.K.","Parker A.","Patel R.","Pearce A.V.","Peck A.I.","Phillimore B.","Phillips S.","Plumb R.W.","Porter K.M.","Ramsey Y.","Ranby S.A.","Rice C.M.","Ross M.T.","Searle S.M.","Sehra H.K.","Sheridan E.","Skuce C.D.","Smith S.","Smith M.","Spraggon L.","Squares S.L.","Steward C.A.","Sycamore N.","Tamlyn-Hall G.","Tester J.","Theaker A.J.","Thomas D.W.","Thorpe A.","Tracey A.","Tromans A.","Tubby B.","Wall M.","Wallis J.M.","West A.P.","White S.S.","Whitehead S.L.","Whittaker H.","Wild A.","Willey D.J.","Wilmer T.E.","Wood J.M.","Wray P.W.","Wyatt J.C.","Young L.","Younger R.M.","Bentley D.R.","Coulson A.","Durbin R.","Hubbard T.","Sulston J.E.","Dunham I.","Rogers J.","Beck S."],"citationCrossReferences":[{"database":"PubMed","id":"14574404"},{"database":"DOI","id":"10.1038/nature02055"}],"title":"The DNA sequence and analysis of human chromosome 6.","publicationDate":"2003","journal":"Nature","firstPage":"805","lastPage":"811","volume":"425"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000431121.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000431121.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Burckstummer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"21269460"}]},{"referenceNumber":5,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"23186163"}]},{"referenceNumber":6,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"24275569"}]},{"referenceNumber":7,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000431121.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL096710","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL137008","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL512422","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL512448","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL590005","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL590037","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"KF458172","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"MassIVE","id":"H0YC82","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"36976","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000518398.2","properties":[{"key":"ProteinId","value":"ENSP00000431121.1"},{"key":"GeneId","value":"ENSG00000151914.22"}]},{"database":"UCSC","id":"uc063pfb.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:1090","properties":[{"key":"GeneName","value":"DST"}]},{"database":"OpenTargets","id":"ENSG00000151914","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000151914","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000155008","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_613322_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"9479997at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"DST","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 6"}]},{"database":"Bgee","id":"ENSG00000151914","properties":[{"key":"ExpressionPatterns","value":"Expressed in corpus callosum and 207 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"H0YC82","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0043226","properties":[{"key":"GoTerm","value":"C:organelle"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd00176","properties":[{"key":"EntryName","value":"SPEC"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000350","properties":[{"key":"EntryName","value":"Dystonin"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000085","properties":[{"key":"EntryName","value":"dystonin isoform X2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.58.60","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR018159","properties":[{"key":"EntryName","value":"Spectrin/alpha-actinin"}]},{"database":"InterPro","id":"IPR002017","properties":[{"key":"EntryName","value":"Spectrin_repeat"}]},{"database":"PANTHER","id":"PTHR11915","properties":[{"key":"EntryName","value":"SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00435","properties":[{"key":"EntryName","value":"Spectrin"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00150","properties":[{"key":"EntryName","value":"SPEC"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF46966","properties":[{"key":"EntryName","value":"Spectrin repeat"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"XVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQDVGTGYCRSSEQYKCHE","length":448,"molWeight":50485,"crc64":"C1577D2250EE4C2C","md5":"9485E90A0BFC48D4FC5E09A38098C2A3"},"extraAttributes":{"countByFeatureType":{"Coiled coil":1,"Non-terminal residue":1},"uniParcId":"UPI0001E8F3CC"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"F6XPT2","uniProtkbId":"F6XPT2_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000431003.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000431003.1"}],"value":"Dystonin"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000431003.1"}],"value":"DST"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004316"}],"value":"Cell projection","id":"SL-0280"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004245"}],"value":"Cytoplasm, cytoskeleton","id":"SL-0090"}}]}],"features":[{"type":"Domain","location":{"start":{"value":561,"modifier":"EXACT"},"end":{"value":618,"modifier":"EXACT"}},"description":"SH3","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50002"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":23,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":408,"modifier":"EXACT"},"end":{"value":442,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":882,"modifier":"EXACT"},"end":{"value":916,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Compositional bias","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":16,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023273"}],"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023212"}],"id":"KW-0206","category":"Cellular component","name":"Cytoskeleton"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"F6XPT2"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"F6XPT2"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022443"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00192"}],"id":"KW-0728","category":"Domain","name":"SH3 domain"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000431003.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"14574404","citationType":"journal article","authors":["Mungall A.J.","Palmer S.A.","Sims S.K.","Edwards C.A.","Ashurst J.L.","Wilming L.","Jones M.C.","Horton R.","Hunt S.E.","Scott C.E.","Gilbert J.G.","Clamp M.E.","Bethel G.","Milne S.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Andrews T.D.","Ashwell R.I.","Babbage A.K.","Bagguley C.L.","Bailey J.","Banerjee R.","Barker D.J.","Barlow K.F.","Bates K.","Beare D.M.","Beasley H.","Beasley O.","Bird C.P.","Blakey S.","Bray-Allen S.","Brook J.","Brown A.J.","Brown J.Y.","Burford D.C.","Burrill W.","Burton J.","Carder C.","Carter N.P.","Chapman J.C.","Clark S.Y.","Clark G.","Clee C.M.","Clegg S.","Cobley V.","Collier R.E.","Collins J.E.","Colman L.K.","Corby N.R.","Coville G.J.","Culley K.M.","Dhami P.","Davies J.","Dunn M.","Earthrowl M.E.","Ellington A.E.","Evans K.A.","Faulkner L.","Francis M.D.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Ghori M.J.","Gilby L.M.","Gillson C.J.","Glithero R.J.","Grafham D.V.","Grant M.","Gribble S.","Griffiths C.","Griffiths M.","Hall R.","Halls K.S.","Hammond S.","Harley J.L.","Hart E.A.","Heath P.D.","Heathcott R.","Holmes S.J.","Howden P.J.","Howe K.L.","Howell G.R.","Huckle E.","Humphray S.J.","Humphries M.D.","Hunt A.R.","Johnson C.M.","Joy A.A.","Kay M.","Keenan S.J.","Kimberley A.M.","King A.","Laird G.K.","Langford C.","Lawlor S.","Leongamornlert D.A.","Leversha M.","Lloyd C.R.","Lloyd D.M.","Loveland J.E.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","Maslen G.L.","Matthews L.","McCann O.T.","McLaren S.J.","McLay K.","McMurray A.","Moore M.J.","Mullikin J.C.","Niblett D.","Nickerson T.","Novik K.L.","Oliver K.","Overton-Larty E.K.","Parker A.","Patel R.","Pearce A.V.","Peck A.I.","Phillimore B.","Phillips S.","Plumb R.W.","Porter K.M.","Ramsey Y.","Ranby S.A.","Rice C.M.","Ross M.T.","Searle S.M.","Sehra H.K.","Sheridan E.","Skuce C.D.","Smith S.","Smith M.","Spraggon L.","Squares S.L.","Steward C.A.","Sycamore N.","Tamlyn-Hall G.","Tester J.","Theaker A.J.","Thomas D.W.","Thorpe A.","Tracey A.","Tromans A.","Tubby B.","Wall M.","Wallis J.M.","West A.P.","White S.S.","Whitehead S.L.","Whittaker H.","Wild A.","Willey D.J.","Wilmer T.E.","Wood J.M.","Wray P.W.","Wyatt J.C.","Young L.","Younger R.M.","Bentley D.R.","Coulson A.","Durbin R.","Hubbard T.","Sulston J.E.","Dunham I.","Rogers J.","Beck S."],"citationCrossReferences":[{"database":"PubMed","id":"14574404"},{"database":"DOI","id":"10.1038/nature02055"}],"title":"The DNA sequence and analysis of human chromosome 6.","publicationDate":"2003","journal":"Nature","firstPage":"805","lastPage":"811","volume":"425"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000431003.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000431003.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Burckstummer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"21269460"}]},{"referenceNumber":5,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"24275569"}]},{"referenceNumber":6,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000431003.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL096710","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL137008","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL512422","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL512448","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL590005","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL590037","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"KF458172","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"DNASU","id":"667","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000518935.5","properties":[{"key":"ProteinId","value":"ENSP00000431003.1"},{"key":"GeneId","value":"ENSG00000151914.22"}]},{"database":"DisGeNET","id":"667","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:1090","properties":[{"key":"GeneName","value":"DST"}]},{"database":"OpenTargets","id":"ENSG00000151914","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000151914","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000155008","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"9479997at2759","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"667","properties":[{"key":"hits","value":"16 hits in 1162 CRISPR screens"}]},{"database":"ChiTaRS","id":"DST","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 6"}]},{"database":"Bgee","id":"ENSG00000151914","properties":[{"key":"ExpressionPatterns","value":"Expressed in corpus callosum and 207 other cell types or tissues"}]},{"database":"CDD","id":"cd00176","properties":[{"key":"EntryName","value":"SPEC"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000009","properties":[{"key":"EntryName","value":"dystonin isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000052","properties":[{"key":"EntryName","value":"dystonin isoform X2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000060","properties":[{"key":"EntryName","value":"dystonin isoform X2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.30.30.40:FF:000011","properties":[{"key":"EntryName","value":"Microtubule-actin cross-linking factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.60:FF:000010","properties":[{"key":"EntryName","value":"plectin isoform X2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.58.1060","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.58.60","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"4"}]},{"database":"Gene3D","id":"2.30.30.40","properties":[{"key":"EntryName","value":"SH3 Domains"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR041615","properties":[{"key":"EntryName","value":"Desmoplakin_SH3"}]},{"database":"InterPro","id":"IPR041573","properties":[{"key":"EntryName","value":"Desmoplakin_Spectrin-like"}]},{"database":"InterPro","id":"IPR049538","properties":[{"key":"EntryName","value":"PCN-like_spectrin-like_rpt"}]},{"database":"InterPro","id":"IPR043197","properties":[{"key":"EntryName","value":"Plakin"}]},{"database":"InterPro","id":"IPR001452","properties":[{"key":"EntryName","value":"SH3_domain"}]},{"database":"InterPro","id":"IPR018159","properties":[{"key":"EntryName","value":"Spectrin/alpha-actinin"}]},{"database":"InterPro","id":"IPR002017","properties":[{"key":"EntryName","value":"Spectrin_repeat"}]},{"database":"PANTHER","id":"PTHR23169:SF24","properties":[{"key":"EntryName","value":"DYSTONIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR23169","properties":[{"key":"EntryName","value":"ENVOPLAKIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF17902","properties":[{"key":"EntryName","value":"SH3_10"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00435","properties":[{"key":"EntryName","value":"Spectrin"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF18373","properties":[{"key":"EntryName","value":"Spectrin_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF21019","properties":[{"key":"EntryName","value":"Spectrin_3"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF21020","properties":[{"key":"EntryName","value":"Spectrin_4"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF27015","properties":[{"key":"EntryName","value":"SR_desmoplakin_3"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF21097","properties":[{"key":"EntryName","value":"SR_plectin_7"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00150","properties":[{"key":"EntryName","value":"SPEC"},{"key":"MatchStatus","value":"3"}]},{"database":"SUPFAM","id":"SSF46966","properties":[{"key":"EntryName","value":"Spectrin repeat"},{"key":"MatchStatus","value":"4"}]},{"database":"PROSITE","id":"PS50002","properties":[{"key":"EntryName","value":"SH3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MHSSSYSYRSSDSVFSNTTSTRTSLDSNENLLLVHCGPTLINSCISFGSESFDGHRLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISGITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPSGLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEVIINSEHPVNIKELEMSSNYSVVWESKTCFMINLCGR","length":1143,"molWeight":132290,"crc64":"F4A7E9590A05067A","md5":"889004E7828F535686C2CC22107F7B8C"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Domain":1,"Region":1,"Coiled coil":2,"Compositional bias":1},"uniParcId":"UPI0000237C88"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"H0YAT7","uniProtkbId":"H0YAT7_HUMAN","entryAudit":{"firstPublicDate":"2012-02-22","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2012-02-22","entryVersion":72,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000428068.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000428068.1"}],"value":"Dystonin"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000428068.1"}],"value":"DST"}}],"features":[{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000428068.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":177,"modifier":"EXACT"},"end":{"value":177,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000428068.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"H0YAT7"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"H0YAT7"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022443"}],"id":"KW-0728","category":"Domain","name":"SH3 domain"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000428068.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"14574404","citationType":"journal article","authors":["Mungall A.J.","Palmer S.A.","Sims S.K.","Edwards C.A.","Ashurst J.L.","Wilming L.","Jones M.C.","Horton R.","Hunt S.E.","Scott C.E.","Gilbert J.G.","Clamp M.E.","Bethel G.","Milne S.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Andrews T.D.","Ashwell R.I.","Babbage A.K.","Bagguley C.L.","Bailey J.","Banerjee R.","Barker D.J.","Barlow K.F.","Bates K.","Beare D.M.","Beasley H.","Beasley O.","Bird C.P.","Blakey S.","Bray-Allen S.","Brook J.","Brown A.J.","Brown J.Y.","Burford D.C.","Burrill W.","Burton J.","Carder C.","Carter N.P.","Chapman J.C.","Clark S.Y.","Clark G.","Clee C.M.","Clegg S.","Cobley V.","Collier R.E.","Collins J.E.","Colman L.K.","Corby N.R.","Coville G.J.","Culley K.M.","Dhami P.","Davies J.","Dunn M.","Earthrowl M.E.","Ellington A.E.","Evans K.A.","Faulkner L.","Francis M.D.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Ghori M.J.","Gilby L.M.","Gillson C.J.","Glithero R.J.","Grafham D.V.","Grant M.","Gribble S.","Griffiths C.","Griffiths M.","Hall R.","Halls K.S.","Hammond S.","Harley J.L.","Hart E.A.","Heath P.D.","Heathcott R.","Holmes S.J.","Howden P.J.","Howe K.L.","Howell G.R.","Huckle E.","Humphray S.J.","Humphries M.D.","Hunt A.R.","Johnson C.M.","Joy A.A.","Kay M.","Keenan S.J.","Kimberley A.M.","King A.","Laird G.K.","Langford C.","Lawlor S.","Leongamornlert D.A.","Leversha M.","Lloyd C.R.","Lloyd D.M.","Loveland J.E.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","Maslen G.L.","Matthews L.","McCann O.T.","McLaren S.J.","McLay K.","McMurray A.","Moore M.J.","Mullikin J.C.","Niblett D.","Nickerson T.","Novik K.L.","Oliver K.","Overton-Larty E.K.","Parker A.","Patel R.","Pearce A.V.","Peck A.I.","Phillimore B.","Phillips S.","Plumb R.W.","Porter K.M.","Ramsey Y.","Ranby S.A.","Rice C.M.","Ross M.T.","Searle S.M.","Sehra H.K.","Sheridan E.","Skuce C.D.","Smith S.","Smith M.","Spraggon L.","Squares S.L.","Steward C.A.","Sycamore N.","Tamlyn-Hall G.","Tester J.","Theaker A.J.","Thomas D.W.","Thorpe A.","Tracey A.","Tromans A.","Tubby B.","Wall M.","Wallis J.M.","West A.P.","White S.S.","Whitehead S.L.","Whittaker H.","Wild A.","Willey D.J.","Wilmer T.E.","Wood J.M.","Wray P.W.","Wyatt J.C.","Young L.","Younger R.M.","Bentley D.R.","Coulson A.","Durbin R.","Hubbard T.","Sulston J.E.","Dunham I.","Rogers J.","Beck S."],"citationCrossReferences":[{"database":"PubMed","id":"14574404"},{"database":"DOI","id":"10.1038/nature02055"}],"title":"The DNA sequence and analysis of human chromosome 6.","publicationDate":"2003","journal":"Nature","firstPage":"805","lastPage":"811","volume":"425"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000428068.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000428068.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"24275569"}]},{"referenceNumber":5,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000428068.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL096710","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL137008","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL512422","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL512448","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL590005","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL590037","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"KF458172","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"MassIVE","id":"H0YAT7","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"36488","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"31066","properties":[{"key":"antibodies","value":"185 antibodies from 24 providers"}]},{"database":"Ensembl","id":"ENST00000522360.5","properties":[{"key":"ProteinId","value":"ENSP00000428068.1"},{"key":"GeneId","value":"ENSG00000151914.22"}]},{"database":"UCSC","id":"uc063pfd.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:1090","properties":[{"key":"GeneName","value":"DST"}]},{"database":"OpenTargets","id":"ENSG00000151914","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000151914","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000155008","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_1528597_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"9479997at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"DST","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 6"}]},{"database":"Bgee","id":"ENSG00000151914","properties":[{"key":"ExpressionPatterns","value":"Expressed in corpus callosum and 207 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"H0YAT7","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0045104","properties":[{"key":"GoTerm","value":"P:intermediate filament cytoskeleton organization"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"FunFam","id":"1.20.58.60:FF:000010","properties":[{"key":"EntryName","value":"plectin isoform X2"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR043197","properties":[{"key":"EntryName","value":"Plakin"}]},{"database":"PANTHER","id":"PTHR23169:SF24","properties":[{"key":"EntryName","value":"DYSTONIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR23169","properties":[{"key":"EntryName","value":"ENVOPLAKIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF27015","properties":[{"key":"EntryName","value":"SR_desmoplakin_3"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF46966","properties":[{"key":"EntryName","value":"Spectrin repeat"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"XQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIAKNKQYDMHTEVTTLKQEKNPVPSAEEWMLEGCRASGGLKKGDFLKKGLEPETFQNFDGDHACSVRDDEFKF","length":177,"molWeight":20692,"crc64":"77C830E644BD7EF4","md5":"563787C4E07531AA152B8219FF4E0372"},"extraAttributes":{"countByFeatureType":{"Non-terminal residue":2},"uniParcId":"UPI0001E8F3D1"}}]}