{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P32926","secondaryAccessions":["A8K2V2"],"uniProtkbId":"DSG3_HUMAN","entryAudit":{"firstPublicDate":"1993-10-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2009-06-16","entryVersion":201,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Desmoglein-3"}},"alternativeNames":[{"fullName":{"value":"130 kDa pemphigus vulgaris antigen"},"shortNames":[{"value":"PVA"}]},{"fullName":{"value":"Cadherin family member 6"}}],"flag":"Precursor"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:3050"}],"value":"DSG3"},"synonyms":[{"value":"CDHF6"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O35902"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22294297"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22796473"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26763450"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31835537"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9701552"}],"value":"A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:31835537). Required for adherens and desmosome junction assembly in response to mechanical force in keratinocytes (PubMed:31835537). Required for desmosome-mediated cell-cell adhesion of cells surrounding the telogen hair club and the basal layer of the outer root sheath epithelium, consequently is essential for the anchoring of telogen hairs in the hair follicle (PubMed:9701552). Required for the maintenance of the epithelial barrier via promoting desmosome-mediated intercellular attachment of suprabasal epithelium to basal cells (By similarity). May play a role in the protein stability of the desmosome plaque components DSP, JUP, PKP1, PKP2 and PKP3 (PubMed:22294297). Required for YAP1 localization at the plasma membrane in keratinocytes in response to mechanical strain, via the formation of an interaction complex composed of DSG3, PKP1 and YWHAG (PubMed:31835537). May also be involved in the positive regulation of YAP1 target gene transcription and as a result cell proliferation (PubMed:31835537). Positively regulates cellular contractility and cell junction formation via organization of cortical F-actin bundles and anchoring of actin to tight junctions, in conjunction with RAC1 (PubMed:22796473). The cytoplasmic pool of DSG3 is required for the localization of CDH1 and CTNNB1 at developing adherens junctions, potentially via modulation of SRC activity (PubMed:22294297). Inhibits keratinocyte migration via suppression of p38MAPK signaling, may therefore play a role in moderating wound healing (PubMed:26763450)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O35902"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11790773"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18343367"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19717567"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22294297"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22796473"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31835537"}],"value":"Homodimer (PubMed:19717567). Part of a complex that contains DSG3, PKP1, YAP1 and YWHAG; the complex is required for localization of DSG3 and YAP1 to the cell membrane in keratinocytes (PubMed:31835537). Interacts with PKP2 (PubMed:11790773). Interacts with CTNND1; the interaction facilitates DSG3 localization and retention at cell-cell junctions (PubMed:18343367). Interacts with CDH1; the interaction is required for CDH1 localization to developing adherens junctions (PubMed:22294297). Interacts with RAC1; the interaction is required for DSG3 translocation to cell-cell junctions, organization of cortical F-actin bundles and actin anchoring at cell-cell junctions (PubMed:22796473). Interacts with DSC3; the interaction may limit the interaction of DSC3 with p38MAPK family members and therefore repress p38MAPK signaling activation (By similarity)"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19717567"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30949721"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31835537"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000255"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O35902"}],"value":"Cell junction, desmosome","id":"SL-0092"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22796473"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31835537"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22796473"}],"value":"Cell junction, tight junction","id":"SL-0265"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18343367"}],"value":"Cell junction","id":"SL-0038"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16740002"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19717567"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22294297"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24220297"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30528827"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9701552"}],"value":"Expressed throughout the basal and spinous layer of the epidermis with weak expression in the granular layer (at protein level) (PubMed:19717567). Expressed in skin and mucosa (at protein level) (PubMed:22294297, PubMed:30528827). Expressed throughout the esophageal mucosa (at protein level) (PubMed:24220297). Expressed in the basal layer of the outer root sheath of the telogen hair club, specifically at the cell membrane between the apex of the cells and the surrounding hair club (at protein level) (PubMed:9701552). Expression is less abundant between the lateral margins of the outer root sheath basal cells (at protein level) (PubMed:9701552). Also expressed in the tongue, tonsil and esophagus (PubMed:16740002)"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31835537"}],"value":"Induced in the hours following cyclic mechanical strain in keratinocytes"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain"}],"commentType":"DOMAIN"},{"commentType":"DISEASE","disease":{"diseaseId":"Blistering, acantholytic, of oral and laryngeal mucosa","diseaseAccession":"DI-06040","acronym":"ABOLM","description":"An autosomal recessive disorder characterized by recurrent, suprabasal acantholytic blisters in the oral and laryngeal mucosa. Skin, conjunctival and genital mucosa, nail folds, and nails are unaffected. Normal structure is observed in the scalp epidermis and hair follicle.","diseaseCrossReference":{"database":"MIM","id":"619226"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30528827"}]},"note":{"texts":[{"value":"The disease may be caused by variants affecting the gene represented in this entry"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1720352"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22294297"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9701552"}],"value":"Pemphigus vulgaris (PV) is a potentially lethal skin disease in which epidermal blisters occur as the result of the loss of cell-cell adhesion caused by the action of autoantibodies against desmoglein 3 (PubMed:1720352). Loss of expression at points of cell-cell contact between the basal and suprabasal layers in blisters and immediately adjacent to blisters in PV (PubMed:22294297). In a PV patient acantholysis extends from the epidermis of the scalp down the entire outer root sheath of mostly empty dilated hair follicles that contain only small residual unanchored hair shafts and necrotic detached cells (PubMed:9701552). Although hair loss is not a major phenotype in PV due to the lower number of hair follicles in telogen phase in humans, this would suggest DSG3 disruption results in hair follicle abnormalities (PubMed:9701552)"}],"commentType":"MISCELLANEOUS"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":23,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Propeptide","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":49,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":"PRO_0000003851"},{"type":"Chain","location":{"start":{"value":50,"modifier":"EXACT"},"end":{"value":999,"modifier":"EXACT"}},"description":"Desmoglein-3","featureId":"PRO_0000003852"},{"type":"Topological domain","location":{"start":{"value":50,"modifier":"EXACT"},"end":{"value":615,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":616,"modifier":"EXACT"},"end":{"value":640,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":641,"modifier":"EXACT"},"end":{"value":999,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Domain","location":{"start":{"value":50,"modifier":"EXACT"},"end":{"value":158,"modifier":"EXACT"}},"description":"Cadherin 1","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00043"}]},{"type":"Domain","location":{"start":{"value":159,"modifier":"EXACT"},"end":{"value":268,"modifier":"EXACT"}},"description":"Cadherin 2","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00043"}]},{"type":"Domain","location":{"start":{"value":269,"modifier":"EXACT"},"end":{"value":383,"modifier":"EXACT"}},"description":"Cadherin 3","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00043"}]},{"type":"Domain","location":{"start":{"value":386,"modifier":"EXACT"},"end":{"value":499,"modifier":"EXACT"}},"description":"Cadherin 4","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00043"}]},{"type":"Repeat","location":{"start":{"value":910,"modifier":"EXACT"},"end":{"value":935,"modifier":"EXACT"}},"description":"Desmoglein repeat 1"},{"type":"Repeat","location":{"start":{"value":936,"modifier":"EXACT"},"end":{"value":966,"modifier":"EXACT"}},"description":"Desmoglein repeat 2"},{"type":"Region","location":{"start":{"value":642,"modifier":"EXACT"},"end":{"value":714,"modifier":"EXACT"}},"description":"Required for interaction with CTNND1 and localization at cell-cell junctions","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O35902"}]},{"type":"Glycosylation","location":{"start":{"value":110,"modifier":"EXACT"},"end":{"value":110,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":180,"modifier":"EXACT"},"end":{"value":180,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":459,"modifier":"EXACT"},"end":{"value":459,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16740002"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":545,"modifier":"EXACT"},"end":{"value":545,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16740002"}],"featureId":""},{"type":"Natural variant","location":{"start":{"value":287,"modifier":"EXACT"},"end":{"value":999,"modifier":"EXACT"}},"description":"in ABOLM; uncertain significance; loss of expression in skin and mucosa","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30528827"}],"featureId":"VAR_085271","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":509,"modifier":"EXACT"},"end":{"value":509,"modifier":"EXACT"}},"description":"in dbSNP:rs16961975","featureCrossReferences":[{"database":"dbSNP","id":"rs16961975"}],"featureId":"VAR_055578","alternativeSequence":{"originalSequence":"V","alternativeSequences":["M"]}},{"type":"Natural variant","location":{"start":{"value":912,"modifier":"EXACT"},"end":{"value":912,"modifier":"EXACT"}},"description":"in dbSNP:rs1380866","featureCrossReferences":[{"database":"dbSNP","id":"rs1380866"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14702039"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1720352"}],"featureId":"VAR_059178","alternativeSequence":{"originalSequence":"T","alternativeSequences":["A"]}},{"type":"Sequence conflict","location":{"start":{"value":110,"modifier":"EXACT"},"end":{"value":110,"modifier":"EXACT"}},"description":"in Ref. 2; BAF83056","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"N","alternativeSequences":["D"]}},{"type":"Sequence conflict","location":{"start":{"value":298,"modifier":"EXACT"},"end":{"value":298,"modifier":"EXACT"}},"description":"in Ref. 2; BAF83056","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"T","alternativeSequences":["A"]}},{"type":"Turn","location":{"start":{"value":65,"modifier":"EXACT"},"end":{"value":67,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5EQX"}]},{"type":"Beta strand","location":{"start":{"value":70,"modifier":"EXACT"},"end":{"value":72,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5EQX"}]},{"type":"Helix","location":{"start":{"value":76,"modifier":"EXACT"},"end":{"value":78,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5EQX"}]},{"type":"Beta strand","location":{"start":{"value":84,"modifier":"EXACT"},"end":{"value":90,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5EQX"}]},{"type":"Turn","location":{"start":{"value":91,"modifier":"EXACT"},"end":{"value":93,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5EQX"}]},{"type":"Beta strand","location":{"start":{"value":94,"modifier":"EXACT"},"end":{"value":96,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5EQX"}]},{"type":"Beta strand","location":{"start":{"value":98,"modifier":"EXACT"},"end":{"value":102,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5EQX"}]},{"type":"Turn","location":{"start":{"value":104,"modifier":"EXACT"},"end":{"value":106,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5EQX"}]},{"type":"Beta strand","location":{"start":{"value":108,"modifier":"EXACT"},"end":{"value":111,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5EQX"}]},{"type":"Turn","location":{"start":{"value":117,"modifier":"EXACT"},"end":{"value":119,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5EQX"}]},{"type":"Beta strand","location":{"start":{"value":121,"modifier":"EXACT"},"end":{"value":130,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5EQX"}]},{"type":"Beta strand","location":{"start":{"value":141,"modifier":"EXACT"},"end":{"value":148,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5EQX"}]},{"type":"Beta strand","location":{"start":{"value":156,"modifier":"EXACT"},"end":{"value":158,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5EQX"}]},{"type":"Beta strand","location":{"start":{"value":160,"modifier":"EXACT"},"end":{"value":166,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5EQX"}]},{"type":"Beta strand","location":{"start":{"value":175,"modifier":"EXACT"},"end":{"value":178,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5EQX"}]},{"type":"Beta strand","location":{"start":{"value":187,"modifier":"EXACT"},"end":{"value":189,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5EQX"}]},{"type":"Turn","location":{"start":{"value":190,"modifier":"EXACT"},"end":{"value":192,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5EQX"}]},{"type":"Beta strand","location":{"start":{"value":198,"modifier":"EXACT"},"end":{"value":201,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5EQX"}]},{"type":"Beta strand","location":{"start":{"value":209,"modifier":"EXACT"},"end":{"value":211,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5EQX"}]},{"type":"Turn","location":{"start":{"value":213,"modifier":"EXACT"},"end":{"value":215,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5EQX"}]},{"type":"Beta strand","location":{"start":{"value":217,"modifier":"EXACT"},"end":{"value":220,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5EQX"}]},{"type":"Turn","location":{"start":{"value":227,"modifier":"EXACT"},"end":{"value":229,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5EQX"}]},{"type":"Beta strand","location":{"start":{"value":231,"modifier":"EXACT"},"end":{"value":241,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5EQX"}]},{"type":"Helix","location":{"start":{"value":242,"modifier":"EXACT"},"end":{"value":244,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5EQX"}]},{"type":"Beta strand","location":{"start":{"value":248,"modifier":"EXACT"},"end":{"value":257,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5EQX"}]},{"type":"Beta strand","location":{"start":{"value":266,"modifier":"EXACT"},"end":{"value":270,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5EQX"}]},{"type":"Beta strand","location":{"start":{"value":272,"modifier":"EXACT"},"end":{"value":277,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5EQX"}]},{"type":"Beta strand","location":{"start":{"value":282,"modifier":"EXACT"},"end":{"value":288,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5EQX"}]},{"type":"Turn","location":{"start":{"value":299,"modifier":"EXACT"},"end":{"value":301,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5EQX"}]},{"type":"Beta strand","location":{"start":{"value":303,"modifier":"EXACT"},"end":{"value":310,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5EQX"}]},{"type":"Beta strand","location":{"start":{"value":316,"modifier":"EXACT"},"end":{"value":320,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5EQX"}]},{"type":"Turn","location":{"start":{"value":322,"modifier":"EXACT"},"end":{"value":324,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5EQX"}]},{"type":"Beta strand","location":{"start":{"value":327,"modifier":"EXACT"},"end":{"value":331,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5EQX"}]},{"type":"Turn","location":{"start":{"value":337,"modifier":"EXACT"},"end":{"value":339,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5EQX"}]},{"type":"Beta strand","location":{"start":{"value":341,"modifier":"EXACT"},"end":{"value":353,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5EQX"}]},{"type":"Helix","location":{"start":{"value":354,"modifier":"EXACT"},"end":{"value":356,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5EQX"}]},{"type":"Turn","location":{"start":{"value":357,"modifier":"EXACT"},"end":{"value":359,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5EQX"}]},{"type":"Helix","location":{"start":{"value":360,"modifier":"EXACT"},"end":{"value":362,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5EQX"}]},{"type":"Beta strand","location":{"start":{"value":368,"modifier":"EXACT"},"end":{"value":375,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5EQX"}]},{"type":"Beta strand","location":{"start":{"value":384,"modifier":"EXACT"},"end":{"value":391,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5EQX"}]},{"type":"Beta strand","location":{"start":{"value":394,"modifier":"EXACT"},"end":{"value":396,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5EQX"}]},{"type":"Beta strand","location":{"start":{"value":412,"modifier":"EXACT"},"end":{"value":419,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5EQX"}]},{"type":"Beta strand","location":{"start":{"value":422,"modifier":"EXACT"},"end":{"value":429,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5EQX"}]},{"type":"Helix","location":{"start":{"value":431,"modifier":"EXACT"},"end":{"value":433,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5EQX"}]},{"type":"Beta strand","location":{"start":{"value":435,"modifier":"EXACT"},"end":{"value":437,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5EQX"}]},{"type":"Turn","location":{"start":{"value":439,"modifier":"EXACT"},"end":{"value":441,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5EQX"}]},{"type":"Beta strand","location":{"start":{"value":443,"modifier":"EXACT"},"end":{"value":446,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5EQX"}]},{"type":"Turn","location":{"start":{"value":453,"modifier":"EXACT"},"end":{"value":456,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5EQX"}]},{"type":"Beta strand","location":{"start":{"value":459,"modifier":"EXACT"},"end":{"value":470,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5EQX"}]},{"type":"Turn","location":{"start":{"value":471,"modifier":"EXACT"},"end":{"value":473,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5EQX"}]},{"type":"Beta strand","location":{"start":{"value":477,"modifier":"EXACT"},"end":{"value":484,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5EQX"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0106","category":"Ligand","name":"Calcium"},{"id":"KW-0130","category":"Biological process","name":"Cell adhesion"},{"id":"KW-0965","category":"Cellular component","name":"Cell junction"},{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-0165","category":"PTM","name":"Cleavage on pair of basic residues"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0677","category":"Domain","name":"Repeat"},{"id":"KW-0732","category":"Domain","name":"Signal"},{"id":"KW-0796","category":"Cellular component","name":"Tight junction"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"1720352","citationType":"journal article","authors":["Amagai M.","Klaus-Kovtun V.","Stanley J.R."],"citationCrossReferences":[{"database":"PubMed","id":"1720352"},{"database":"DOI","id":"10.1016/0092-8674(91)90360-b"}],"title":"Autoantibodies against a novel epithelial cadherin in pemphigus vulgaris, a disease of cell adhesion.","publicationDate":"1991","journal":"Cell","firstPage":"869","lastPage":"877","volume":"67"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]","INVOLVEMENT IN PEMPHIGUS VULGARIS","VARIANT ALA-912"]},{"referenceNumber":2,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]","VARIANT ALA-912"],"referenceComments":[{"value":"Tongue","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"16177791","citationType":"journal article","authors":["Nusbaum C.","Zody M.C.","Borowsky M.L.","Kamal M.","Kodira C.D.","Taylor T.D.","Whittaker C.A.","Chang J.L.","Cuomo C.A.","Dewar K.","FitzGerald M.G.","Yang X.","Abouelleil A.","Allen N.R.","Anderson S.","Bloom T.","Bugalter B.","Butler J.","Cook A.","DeCaprio D.","Engels R.","Garber M.","Gnirke A.","Hafez N.","Hall J.L.","Norman C.H.","Itoh T.","Jaffe D.B.","Kuroki Y.","Lehoczky J.","Lui A.","Macdonald P.","Mauceli E.","Mikkelsen T.S.","Naylor J.W.","Nicol R.","Nguyen C.","Noguchi H.","O'Leary S.B.","Piqani B.","Smith C.L.","Talamas J.A.","Topham K.","Totoki Y.","Toyoda A.","Wain H.M.","Young S.K.","Zeng Q.","Zimmer A.R.","Fujiyama A.","Hattori M.","Birren B.W.","Sakaki Y.","Lander E.S."],"citationCrossReferences":[{"database":"PubMed","id":"16177791"},{"database":"DOI","id":"10.1038/nature03983"}],"title":"DNA sequence and analysis of human chromosome 18.","publicationDate":"2005","journal":"Nature","firstPage":"551","lastPage":"555","volume":"437"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":4,"citation":{"id":"9701552","citationType":"journal article","authors":["Koch P.J.","Mahoney M.G.","Cotsarelis G.","Rothenberger K.","Lavker R.M.","Stanley J.R."],"citationCrossReferences":[{"database":"PubMed","id":"9701552"},{"database":"DOI","id":"10.1242/jcs.111.17.2529"}],"title":"Desmoglein 3 anchors telogen hair in the follicle.","publicationDate":"1998","journal":"J. Cell Sci.","firstPage":"2529","lastPage":"2537","volume":"111"},"referencePositions":["FUNCTION","TISSUE SPECIFICITY"]},{"referenceNumber":5,"citation":{"id":"11790773","citationType":"journal article","authors":["Chen X.","Bonne S.","Hatzfeld M.","van Roy F.","Green K.J."],"citationCrossReferences":[{"database":"PubMed","id":"11790773"},{"database":"DOI","id":"10.1074/jbc.m108765200"}],"title":"Protein binding and functional characterization of plakophilin 2. Evidence for its diverse roles in desmosomes and beta -catenin signaling.","publicationDate":"2002","journal":"J. Biol. Chem.","firstPage":"10512","lastPage":"10522","volume":"277"},"referencePositions":["INTERACTION WITH PKP2"]},{"referenceNumber":6,"citation":{"id":"16740002","citationType":"journal article","authors":["Ramachandran P.","Boontheung P.","Xie Y.","Sondej M.","Wong D.T.","Loo J.A."],"citationCrossReferences":[{"database":"PubMed","id":"16740002"},{"database":"DOI","id":"10.1021/pr050492k"}],"title":"Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry.","publicationDate":"2006","journal":"J. Proteome Res.","firstPage":"1493","lastPage":"1503","volume":"5"},"referencePositions":["GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-459 AND ASN-545","TISSUE SPECIFICITY"],"referenceComments":[{"value":"Saliva","type":"TISSUE"}]},{"referenceNumber":7,"citation":{"id":"18343367","citationType":"journal article","authors":["Kanno M.","Isa Y.","Aoyama Y.","Yamamoto Y.","Nagai M.","Ozawa M.","Kitajima Y."],"citationCrossReferences":[{"database":"PubMed","id":"18343367"},{"database":"DOI","id":"10.1016/j.yexcr.2008.01.031"}],"title":"P120-catenin is a novel desmoglein 3 interacting partner: identification of the p120-catenin association site of desmoglein 3.","publicationDate":"2008","journal":"Exp. Cell Res.","firstPage":"1683","lastPage":"1692","volume":"314"},"referencePositions":["INTERACTION WITH CTNND1","SUBCELLULAR LOCATION"]},{"referenceNumber":8,"citation":{"id":"19717567","citationType":"journal article","authors":["Spindler V.","Heupel W.M.","Efthymiadis A.","Schmidt E.","Eming R.","Rankl C.","Hinterdorfer P.","Mueller T.","Drenckhahn D.","Waschke J."],"citationCrossReferences":[{"database":"PubMed","id":"19717567"},{"database":"DOI","id":"10.1074/jbc.m109.024810"}],"title":"Desmocollin 3-mediated binding is crucial for keratinocyte cohesion and is impaired in pemphigus.","publicationDate":"2009","journal":"J. Biol. Chem.","firstPage":"30556","lastPage":"30564","volume":"284"},"referencePositions":["SUBUNIT","SUBCELLULAR LOCATION","TISSUE SPECIFICITY"]},{"referenceNumber":9,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Buerckstuemmer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":10,"citation":{"id":"22796473","citationType":"journal article","authors":["Tsang S.M.","Brown L.","Gadmor H.","Gammon L.","Fortune F.","Wheeler A.","Wan H."],"citationCrossReferences":[{"database":"PubMed","id":"22796473"},{"database":"DOI","id":"10.1016/j.yexcr.2012.07.002"}],"title":"Desmoglein 3 acting as an upstream regulator of Rho GTPases, Rac-1/Cdc42 in the regulation of actin organisation and dynamics.","publicationDate":"2012","journal":"Exp. Cell Res.","firstPage":"2269","lastPage":"2283","volume":"318"},"referencePositions":["FUNCTION","INTERACTION WITH RAC1","SUBCELLULAR LOCATION"]},{"referenceNumber":11,"citation":{"id":"22294297","citationType":"journal article","authors":["Tsang S.M.","Brown L.","Lin K.","Liu L.","Piper K.","O'Toole E.A.","Grose R.","Hart I.R.","Garrod D.R.","Fortune F.","Wan H."],"citationCrossReferences":[{"database":"PubMed","id":"22294297"},{"database":"DOI","id":"10.1002/path.3982"}],"title":"Non-junctional human desmoglein 3 acts as an upstream regulator of Src in E-cadherin adhesion, a pathway possibly involved in the pathogenesis of pemphigus vulgaris.","publicationDate":"2012","journal":"J. Pathol.","firstPage":"81","lastPage":"93","volume":"227"},"referencePositions":["FUNCTION","INTERACTION WITH CDH1","TISSUE SPECIFICITY"]},{"referenceNumber":12,"citation":{"id":"24220297","citationType":"journal article","authors":["Sherrill J.D.","Kc K.","Wu D.","Djukic Z.","Caldwell J.M.","Stucke E.M.","Kemme K.A.","Costello M.S.","Mingler M.K.","Blanchard C.","Collins M.H.","Abonia J.P.","Putnam P.E.","Dellon E.S.","Orlando R.C.","Hogan S.P.","Rothenberg M.E."],"citationCrossReferences":[{"database":"PubMed","id":"24220297"},{"database":"DOI","id":"10.1038/mi.2013.90"}],"title":"Desmoglein-1 regulates esophageal epithelial barrier function and immune responses in eosinophilic esophagitis.","publicationDate":"2014","journal":"Mucosal Immunol.","firstPage":"718","lastPage":"729","volume":"7"},"referencePositions":["TISSUE SPECIFICITY"]},{"referenceNumber":13,"citation":{"id":"26763450","citationType":"journal article","authors":["Roetzer V.","Hartlieb E.","Winkler J.","Walter E.","Schlipp A.","Sardy M.","Spindler V.","Waschke J."],"citationCrossReferences":[{"database":"PubMed","id":"26763450"},{"database":"DOI","id":"10.1038/jid.2015.380"}],"title":"Desmoglein 3-Dependent Signaling Regulates Keratinocyte Migration and Wound Healing.","publicationDate":"2016","journal":"J. Invest. Dermatol.","firstPage":"301","lastPage":"310","volume":"136"},"referencePositions":["FUNCTION"]},{"referenceNumber":14,"citation":{"id":"30949721","citationType":"journal article","authors":["Fuchs M.","Foresti M.","Radeva M.Y.","Kugelmann D.","Keil R.","Hatzfeld M.","Spindler V.","Waschke J.","Vielmuth F."],"citationCrossReferences":[{"database":"PubMed","id":"30949721"},{"database":"DOI","id":"10.1007/s00018-019-03083-8"}],"title":"Plakophilin 1 but not plakophilin 3 regulates desmoglein clustering.","publicationDate":"2019","journal":"Cell. Mol. Life Sci.","firstPage":"3465","lastPage":"3476","volume":"76"},"referencePositions":["SUBCELLULAR LOCATION"]},{"referenceNumber":15,"citation":{"id":"31835537","citationType":"journal article","authors":["Uttagomol J.","Ahmad U.S.","Rehman A.","Huang Y.","Laly A.C.","Kang A.","Soetaert J.","Chance R.","Teh M.T.","Connelly J.T.","Wan H."],"citationCrossReferences":[{"database":"PubMed","id":"31835537"},{"database":"DOI","id":"10.3390/ijms20246221"}],"title":"Evidence for the Desmosomal Cadherin Desmoglein-3 in Regulating YAP and Phospho-YAP in Keratinocyte Responses to Mechanical Forces.","publicationDate":"2019","journal":"Int. J. Mol. Sci.","firstPage":"0","lastPage":"0","volume":"20"},"referencePositions":["FUNCTION","IDENTIFICATION IN A COMPLEX WITH PKP1; YAP1 AND YWHAG","INTERACTION WITH PKP1; YAP1 AND YWHAG","SUBCELLULAR LOCATION","INDUCTION"]},{"referenceNumber":16,"citation":{"id":"30528827","citationType":"journal article","authors":["Kim J.H.","Kim S.E.","Park H.S.","Lee S.H.","Lee S.E.","Kim S.C."],"citationCrossReferences":[{"database":"PubMed","id":"30528827"},{"database":"DOI","id":"10.1016/j.jid.2018.09.038"}],"title":"A Homozygous Nonsense Mutation in the DSG3 Gene Causes Acantholytic Blisters in the Oral and Laryngeal Mucosa.","publicationDate":"2019","journal":"J. Invest. Dermatol.","firstPage":"1187","lastPage":"1190","volume":"139"},"referencePositions":["VARIANT ABOLM 287-ARG--ILE-999 DEL","CHARACTERIZATION OF VARIANT ABOLM 287-ARG--ILE-999 DEL","TISSUE SPECIFICITY"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"M76482","properties":[{"key":"ProteinId","value":"AAA60230.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK290367","properties":[{"key":"ProteinId","value":"BAF83056.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AC021549","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS11898.1","properties":[{"key":"Description","value":"-"}]},{"database":"PIR","id":"A41088","properties":[{"key":"EntryName","value":"IJHUG3"}]},{"database":"RefSeq","id":"NP_001935.2","properties":[{"key":"NucleotideSequenceId","value":"NM_001944.3"}]},{"database":"PDB","id":"5EQX","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.05 A"},{"key":"Chains","value":"A=50-598"}]},{"database":"PDBsum","id":"5EQX","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"P32926","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P32926","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"108164","properties":[{"key":"Interactions","value":"48"}]},{"database":"ELM","id":"P32926","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P32926","properties":[{"key":"Number of interactors","value":"72"}]},{"database":"IntAct","id":"P32926","properties":[{"key":"Interactions","value":"30"}]},{"database":"STRING","id":"9606.ENSP00000257189","properties":[{"key":"Description","value":"-"}]},{"database":"Allergome","id":"8248","properties":[{"key":"AllergenName","value":"Hom s DSG3"}]},{"database":"TCDB","id":"8.A.204.1.7","properties":[{"key":"FamilyName","value":"the cadhesin (cdh) family"}]},{"database":"GlyCosmos","id":"P32926","properties":[{"key":"glycosylation","value":"4 sites, No reported glycans"}]},{"database":"GlyGen","id":"P32926","properties":[{"key":"glycosylation","value":"12 sites, 2 O-linked glycans (5 sites)"}]},{"database":"iPTMnet","id":"P32926","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"P32926","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"P32926","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"DSG3","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"239938621","properties":[{"key":"Description","value":"-"}]},{"database":"CPTAC","id":"CPTAC-62","properties":[{"key":"Description","value":"-"}]},{"database":"CPTAC","id":"CPTAC-63","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"P32926","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"P32926","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000257189","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P32926","properties":[{"key":"Description","value":"-"}]},{"database":"PRIDE","id":"P32926","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"54887","properties":[{"key":"Description","value":"-"}]},{"database":"ABCD","id":"P32926","properties":[{"key":"antibodies","value":"49 sequenced antibodies"}]},{"database":"Antibodypedia","id":"3464","properties":[{"key":"antibodies","value":"829 antibodies from 39 providers"}]},{"database":"DNASU","id":"1830","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000257189.5","properties":[{"key":"ProteinId","value":"ENSP00000257189.4"},{"key":"GeneId","value":"ENSG00000134757.6"}]},{"database":"GeneID","id":"1830","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:1830","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000257189.5","properties":[{"key":"ProteinId","value":"ENSP00000257189.4"},{"key":"RefSeqNucleotideId","value":"NM_001944.3"},{"key":"RefSeqProteinId","value":"NP_001935.2"}]},{"database":"UCSC","id":"uc002kws.4","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:3050","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA27503","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"1830","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"1830","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"DSG3","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:3050","properties":[{"key":"GeneName","value":"DSG3"}]},{"database":"HPA","id":"ENSG00000134757","properties":[{"key":"ExpressionPatterns","value":"Tissue enhanced (cervix, esophagus, vagina)"}]},{"database":"MalaCards","id":"DSG3","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"169615","properties":[{"key":"Type","value":"gene"}]},{"database":"MIM","id":"619226","properties":[{"key":"Type","value":"phenotype"}]},{"database":"OpenTargets","id":"ENSG00000134757","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000134757","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG3594","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT01030000234624","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_005284_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P32926","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"CQCDNRD","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"8961010at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"P32926","properties":[{"key":"Number of GO annotations","value":"3 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"P32926","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"P32926","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-351906","properties":[{"key":"PathwayName","value":"Apoptotic cleavage of cell adhesion proteins"}]},{"database":"Reactome","id":"R-HSA-6805567","properties":[{"key":"PathwayName","value":"Keratinization"}]},{"database":"Reactome","id":"R-HSA-6809371","properties":[{"key":"PathwayName","value":"Formation of the cornified envelope"}]},{"database":"SignaLink","id":"P32926","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000134757","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"1830","properties":[{"key":"hits","value":"10 hits in 1141 CRISPR screens"}]},{"database":"ChiTaRS","id":"DSG3","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GeneWiki","id":"Desmoglein_3","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"1830","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"P32926","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:P32926","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 18"}]},{"database":"RNAct","id":"P32926","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000134757","properties":[{"key":"ExpressionPatterns","value":"Expressed in gingiva and 102 other cell types or tissues"}]},{"database":"GO","id":"GO:0070161","properties":[{"key":"GoTerm","value":"C:anchoring junction"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18343367"}]},{"database":"GO","id":"GO:0005923","properties":[{"key":"GoTerm","value":"C:bicellular tight junction"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0030054","properties":[{"key":"GoTerm","value":"C:cell junction"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22796473"}]},{"database":"GO","id":"GO:0005911","properties":[{"key":"GoTerm","value":"C:cell-cell junction"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18343367"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19717567"}]},{"database":"GO","id":"GO:0001533","properties":[{"key":"GoTerm","value":"C:cornified envelope"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22796473"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"31835537"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0030057","properties":[{"key":"GoTerm","value":"C:desmosome"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0070062","properties":[{"key":"GoTerm","value":"C:extracellular exosome"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"19056867"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"30949721"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"31835537"}]},{"database":"GO","id":"GO:0070160","properties":[{"key":"GoTerm","value":"C:tight junction"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0005509","properties":[{"key":"GoTerm","value":"F:calcium ion binding"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0046983","properties":[{"key":"GoTerm","value":"F:protein dimerization activity"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0007015","properties":[{"key":"GoTerm","value":"P:actin filament organization"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0034333","properties":[{"key":"GoTerm","value":"P:adherens junction assembly"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"31835537"}]},{"database":"GO","id":"GO:0098609","properties":[{"key":"GoTerm","value":"P:cell-cell adhesion"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0002159","properties":[{"key":"GoTerm","value":"P:desmosome assembly"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"9701552"}]},{"database":"GO","id":"GO:0007156","properties":[{"key":"GoTerm","value":"P:homophilic cell-cell adhesion"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0030336","properties":[{"key":"GoTerm","value":"P:negative regulation of cell migration"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"26763450"}]},{"database":"GO","id":"GO:1903753","properties":[{"key":"GoTerm","value":"P:negative regulation of p38MAPK cascade"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"26763450"}]},{"database":"GO","id":"GO:1903348","properties":[{"key":"GoTerm","value":"P:positive regulation of bicellular tight junction assembly"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:1904704","properties":[{"key":"GoTerm","value":"P:positive regulation of protein localization to adherens junction"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"22294297"}]},{"database":"GO","id":"GO:1905477","properties":[{"key":"GoTerm","value":"P:positive regulation of protein localization to membrane"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"31835537"}]},{"database":"GO","id":"GO:0031647","properties":[{"key":"GoTerm","value":"P:regulation of protein stability"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"22294297"}]},{"database":"GO","id":"GO:0120192","properties":[{"key":"GoTerm","value":"P:tight junction assembly"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"31835537"}]},{"database":"CDD","id":"cd11304","properties":[{"key":"EntryName","value":"Cadherin_repeat"},{"key":"MatchStatus","value":"4"}]},{"database":"FunFam","id":"2.60.40.60:FF:000011","properties":[{"key":"EntryName","value":"Cadherin 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.60:FF:000031","properties":[{"key":"EntryName","value":"Cadherin 3"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.60:FF:000068","properties":[{"key":"EntryName","value":"Desmoglein 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.60:FF:000083","properties":[{"key":"EntryName","value":"Desmoglein 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"4.10.900.10:FF:000003","properties":[{"key":"EntryName","value":"Desmoglein 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.60:FF:000074","properties":[{"key":"EntryName","value":"Desmoglein 4"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.60","properties":[{"key":"EntryName","value":"Cadherins"},{"key":"MatchStatus","value":"5"}]},{"database":"Gene3D","id":"4.10.900.10","properties":[{"key":"EntryName","value":"TCF3-CBD (Catenin binding domain)"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR050971","properties":[{"key":"EntryName","value":"Cadherin-domain_protein"}]},{"database":"InterPro","id":"IPR002126","properties":[{"key":"EntryName","value":"Cadherin-like_dom"}]},{"database":"InterPro","id":"IPR015919","properties":[{"key":"EntryName","value":"Cadherin-like_sf"}]},{"database":"InterPro","id":"IPR020894","properties":[{"key":"EntryName","value":"Cadherin_CS"}]},{"database":"InterPro","id":"IPR027397","properties":[{"key":"EntryName","value":"Catenin-bd_sf"}]},{"database":"InterPro","id":"IPR009122","properties":[{"key":"EntryName","value":"Desmosomal_cadherin"}]},{"database":"PANTHER","id":"PTHR24025","properties":[{"key":"EntryName","value":"DESMOGLEIN FAMILY MEMBER"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR24025:SF3","properties":[{"key":"EntryName","value":"DESMOGLEIN-3"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00028","properties":[{"key":"EntryName","value":"Cadherin"},{"key":"MatchStatus","value":"3"}]},{"database":"PRINTS","id":"PR00205","properties":[{"key":"EntryName","value":"CADHERIN"}]},{"database":"PRINTS","id":"PR01818","properties":[{"key":"EntryName","value":"DESMOCADHERN"}]},{"database":"PRINTS","id":"PR01819","properties":[{"key":"EntryName","value":"DESMOGLEIN"}]},{"database":"SMART","id":"SM00112","properties":[{"key":"EntryName","value":"CA"},{"key":"MatchStatus","value":"4"}]},{"database":"SUPFAM","id":"SSF49313","properties":[{"key":"EntryName","value":"Cadherin-like"},{"key":"MatchStatus","value":"4"}]},{"database":"PROSITE","id":"PS00232","properties":[{"key":"EntryName","value":"CADHERIN_1"},{"key":"MatchStatus","value":"3"}]},{"database":"PROSITE","id":"PS50268","properties":[{"key":"EntryName","value":"CADHERIN_2"},{"key":"MatchStatus","value":"4"}]}],"sequence":{"value":"MMGLFPRTTGALAIFVVVILVHGELRIETKGQYDEEEMTMQQAKRRQKREWVKFAKPCREGEDNSKRNPIAKITSDYQATQKITYRISGVGIDQPPFGIFVVDKNTGDINITAIVDREETPSFLITCRALNAQGLDVEKPLILTVKILDINDNPPVFSQQIFMGEIEENSASNSLVMILNATDADEPNHLNSKIAFKIVSQEPAGTPMFLLSRNTGEVRTLTNSLDREQASSYRLVVSGADKDGEGLSTQCECNIKVKDVNDNFPMFRDSQYSARIEENILSSELLRFQVTDLDEEYTDNWLAVYFFTSGNEGNWFEIQTDPRTNEGILKVVKALDYEQLQSVKLSIAVKNKAEFHQSVISRYRVQSTPVTIQVINVREGIAFRPASKTFTVQKGISSKKLVDYILGTYQAIDEDTNKAASNVKYVMGRNDGGYLMIDSKTAEIKFVKNMNRDSTFIVNKTITAEVLAIDEYTGKTSTGTVYVRVPDFNDNCPTAVLEKDAVCSSSPSVVVSARTLNNRYTGPYTFALEDQPVKLPAVWSITTLNATSALLRAQEQIPPGVYHISLVLTDSQNNRCEMPRSLTLEVCQCDNRGICGTSYPTTSPGTRYGRPHSGRLGPAAIGLLLLGLLLLLLAPLLLLTCDCGAGSTGGVTGGFIPVPDGSEGTIHQWGIEGAHPEDKEITNICVPPVTANGADFMESSEVCTNTYARGTAVEGTSGMEMTTKLGAATESGGAAGFATGTVSGAASGFGAATGVGICSSGQSGTMRTRHSTGGTNKDYADGAISMNFLDSYFSQKAFACAEEDDGQEANDCLLIYDNEGADATGSPVGSVGCCSFIADDLDDSFLDSLGPKFKKLAEISLGVDGEGKEVQPPSKDSGYGIESCGHPIEVQQTGFVKCQTLSGSQGASALSTSGSVQPAVSIPDPLQHGNYLVTETYSASGSLVQPSTAGFDPLLTQNVIVTERVICPISSVPGNLAGPTQLRGSHTMLCTEDPCSRLI","length":999,"molWeight":107533,"crc64":"7553CC917E8719BA","md5":"E608061D1317CECAAF37610D969D18F5"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1,"INDUCTION":1,"DOMAIN":1,"DISEASE":1,"MISCELLANEOUS":1},"countByFeatureType":{"Signal":1,"Propeptide":1,"Chain":1,"Topological domain":2,"Transmembrane":1,"Domain":4,"Repeat":2,"Region":1,"Glycosylation":4,"Natural variant":3,"Sequence conflict":2,"Turn":14,"Beta strand":32,"Helix":5},"uniParcId":"UPI000013CF4B"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8Q9D5","uniProtkbId":"A0ACI8Q9D5_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000521391.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000521391.1"}],"value":"Desmoglein 3"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000521391.1"}],"value":"DSG3"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004568"}],"value":"Cell junction, desmosome","id":"SL-0092"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]}],"features":[{"type":"Domain","location":{"start":{"value":13,"modifier":"EXACT"},"end":{"value":132,"modifier":"EXACT"}},"description":"Cadherin","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50268"}]},{"type":"Domain","location":{"start":{"value":129,"modifier":"EXACT"},"end":{"value":240,"modifier":"EXACT"}},"description":"Cadherin","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50268"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022837"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00043"}],"id":"KW-0106","category":"Ligand","name":"Calcium"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022889"}],"id":"KW-0130","category":"Biological process","name":"Cell adhesion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022949"}],"id":"KW-0965","category":"Cellular component","name":"Cell junction"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8Q9D5"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8Q9D5"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000521391.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000521391.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16177791","citationType":"journal article","authors":["Nusbaum C.","Zody M.C.","Borowsky M.L.","Kamal M.","Kodira C.D.","Taylor T.D.","Whittaker C.A.","Chang J.L.","Cuomo C.A.","Dewar K.","FitzGerald M.G.","Yang X.","Abouelleil A.","Allen N.R.","Anderson S.","Bloom T.","Bugalter B.","Butler J.","Cook A.","DeCaprio D.","Engels R.","Garber M.","Gnirke A.","Hafez N.","Hall J.L.","Norman C.H.","Itoh T.","Jaffe D.B.","Kuroki Y.","Lehoczky J.","Lui A.","Macdonald P.","Mauceli E.","Mikkelsen T.S.","Naylor J.W.","Nicol R.","Nguyen C.","Noguchi H.","O'Leary S.B.","O'Neill K.","Piqani B.","Smith C.L.","Talamas J.A.","Topham K.","Totoki Y.","Toyoda A.","Wain H.M.","Young S.K.","Zeng Q.","Zimmer A.R.","Fujiyama A.","Hattori M.","Birren B.W.","Sakaki Y.","Lander E.S."],"citationCrossReferences":[{"database":"PubMed","id":"16177791"},{"database":"DOI","id":"10.1038/nature03983"}],"title":"DNA sequence and analysis of human chromosome 18.","publicationDate":"2005","journal":"Nature","firstPage":"551","lastPage":"555","volume":"437"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000521391.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000521391.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC021549","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000851332.1","properties":[{"key":"ProteinId","value":"ENSP00000521391.1"},{"key":"GeneId","value":"ENSG00000134757.6"}]},{"database":"HGNC","id":"HGNC:3050","properties":[{"key":"GeneName","value":"DSG3"}]},{"database":"OpenTargets","id":"ENSG00000134757","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT01030000234624","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 18"}]},{"database":"CDD","id":"cd11304","properties":[{"key":"EntryName","value":"Cadherin_repeat"},{"key":"MatchStatus","value":"2"}]},{"database":"FunFam","id":"2.60.40.60:FF:000031","properties":[{"key":"EntryName","value":"Cadherin 3"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.60:FF:000083","properties":[{"key":"EntryName","value":"Desmoglein 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"4.10.900.10:FF:000003","properties":[{"key":"EntryName","value":"Desmoglein 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.60:FF:000074","properties":[{"key":"EntryName","value":"Desmoglein 4"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.60","properties":[{"key":"EntryName","value":"Cadherins"},{"key":"MatchStatus","value":"3"}]},{"database":"Gene3D","id":"4.10.900.10","properties":[{"key":"EntryName","value":"TCF3-CBD (Catenin binding domain)"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR050971","properties":[{"key":"EntryName","value":"Cadherin-domain_protein"}]},{"database":"InterPro","id":"IPR002126","properties":[{"key":"EntryName","value":"Cadherin-like_dom"}]},{"database":"InterPro","id":"IPR015919","properties":[{"key":"EntryName","value":"Cadherin-like_sf"}]},{"database":"InterPro","id":"IPR020894","properties":[{"key":"EntryName","value":"Cadherin_CS"}]},{"database":"InterPro","id":"IPR027397","properties":[{"key":"EntryName","value":"Catenin-bd_sf"}]},{"database":"InterPro","id":"IPR009122","properties":[{"key":"EntryName","value":"Desmosomal_cadherin"}]},{"database":"PANTHER","id":"PTHR24025","properties":[{"key":"EntryName","value":"DESMOGLEIN FAMILY MEMBER"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR24025:SF3","properties":[{"key":"EntryName","value":"DESMOGLEIN-3"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00028","properties":[{"key":"EntryName","value":"Cadherin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00205","properties":[{"key":"EntryName","value":"CADHERIN"}]},{"database":"PRINTS","id":"PR01818","properties":[{"key":"EntryName","value":"DESMOCADHERN"}]},{"database":"PRINTS","id":"PR01819","properties":[{"key":"EntryName","value":"DESMOGLEIN"}]},{"database":"SMART","id":"SM00112","properties":[{"key":"EntryName","value":"CA"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF49313","properties":[{"key":"EntryName","value":"Cadherin-like"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS00232","properties":[{"key":"EntryName","value":"CADHERIN_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50268","properties":[{"key":"EntryName","value":"CADHERIN_2"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MMGLFPRTTGALAIFVYSARIEENILSSELLRFQVTDLDEEYTDNWLAVYFFTSGNEGNWFEIQTDPRTNEGILKVVKALDYEQLQSVKLSIAVKNKAEFHQSVISRYRVQSTPVTIQVINVREGIAFRPASKTFTVQKGISSKKLVDYILGTYQAIDEDTNKAASNVKYVMGRNDGGYLMIDSKTAEIKFVKNMNRDSTFIVNKTITAEVLAIDEYTGKTSTGTVYVRVPDFNDNCPTAVLEKDAVCSSSPSVVVSARTLNNRYTGPYTFALEDQPVKLPAVWSITTLNATSALLRAQEQIPPGVYHISLVLTDSQNNRCEMPRSLTLEVCQCDNRGICGTSYPTTSPGTRYGRPHSGRLGPAAIGLLLLGLLLLLLAPLLLLTCDCGAGSTGGVTGGFIPVPDGSEGTIHQWGIEGAHPEDKEITNICVPPVTANGADFMESSEVCTNTYARGTAVEGTSGMEMTTKLGAATESGGAAGFATGTVSGAASGFGAATGVGICSSGQSGTMRTRHSTGGTNKDYADGAISMNFLDSYFSQKAFACAEEDDGQEANDCLLIYDNEGADATGSPVGSVGCCSFIADDLDDSFLDSLGPKFKKLAEISLGVDGEGKEVQPPSKDSGYGIESCGHPIEVQQTGFVKCQTLSGSQGASALSTSGSVQPAVSIPDPLQHGNYLVTETYSASGSLVQPSTAGFDPLLTQNVIVTERVICPISSVPGNLAGPTQLRGSHTMLCTEDPCSRLI","length":744,"molWeight":78982,"crc64":"5672B8AB2A07283E","md5":"9E8415537F1A2C72923D01A3E5262E7C"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Domain":2},"uniParcId":"UPI0040317E50"}}]}