{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P25686","secondaryAccessions":["A8K9P6","Q53QD7","Q8IUK1","Q8IUK2","Q96F52"],"uniProtkbId":"DNJB2_HUMAN","entryAudit":{"firstPublicDate":"1992-05-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2007-09-11","entryVersion":217,"sequenceVersion":3},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"DnaJ homolog subfamily B member 2"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"MIM","id":"604139"}],"value":"Heat shock 40 kDa protein 3"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"1599432"}],"value":"Heat shock protein J1"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"1599432"}],"value":"HSJ-1"}]}],"flag":"Precursor"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:5228"}],"value":"DNAJB2"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"1599432"}],"value":"HSJ1"},{"evidences":[{"evidenceCode":"ECO:0000312","source":"MIM","id":"604139"}],"value":"HSPF3"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12754272"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15936278"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20889486"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21625540"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21719532"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22219199"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22396390"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24023695"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7957263"}],"value":"Functions as a co-chaperone, regulating the substrate binding and activating the ATPase activity of chaperones of the HSP70/heat shock protein 70 family (PubMed:22219199, PubMed:7957263). In parallel, also contributes to the ubiquitin-dependent proteasomal degradation of misfolded proteins (PubMed:15936278, PubMed:21625540). Thereby, may regulate the aggregation and promote the functional recovery of misfolded proteins like HTT, MC4R, PRKN, RHO and SOD1 and be crucial for many biological processes (PubMed:12754272, PubMed:20889486, PubMed:21719532, PubMed:22396390, PubMed:24023695). Isoform 1 which is localized to the endoplasmic reticulum membranes may specifically function in ER-associated protein degradation of misfolded proteins (PubMed:15936278)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15936278"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21625540"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22219199"}],"value":"Interacts with HSP70 (HSPA1A or HSPA1B) (PubMed:21625540, PubMed:22219199). Interacts with HSPA8/Hsc70 (PubMed:15936278). Interacts with PSMA3 and most probably with the whole proteasomal complex (PubMed:15936278)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P25686","intActId":"EBI-6166532"},"interactantTwo":{"uniProtKBAccession":"P58340","geneName":"MLF1","intActId":"EBI-721328"},"numberOfExperiments":2,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","molecule":"Isoform 2","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12754272"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21625540"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12754272"}],"value":"Nucleus","id":"SL-0191"}}]},{"commentType":"SUBCELLULAR LOCATION","molecule":"Isoform 1","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12754272"}],"value":"Endoplasmic reticulum membrane","id":"SL-0097"},"topology":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12754272"}],"value":"Lipid-anchor","id":"SL-9901"},"orientation":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12754272"}],"value":"Cytoplasmic side","id":"SL-9910"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"1599432"}],"value":"HSJ1b"}],"isoformIds":["P25686-3"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"1599432"}],"value":"HSJ1a"},{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"20889486"}],"value":"DNAJB2a"}],"isoformIds":["P25686-2"],"sequenceIds":["VSP_001286","VSP_001287"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12754272"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1599432"}],"value":"More abundantly expressed in neocortex, cerebellum, spinal cord and retina where it is expressed by neuronal cells (at protein level) (PubMed:12754272, PubMed:1599432). Detected at much lower level in non-neuronal tissues including kidney, lung, heart, skeletal muscle, spleen and testis (at protein level) (PubMed:12754272, PubMed:1599432). Isoform 1 is more abundant in neocortex and cerebellum compared to isoform 2 (at protein level) (PubMed:12754272)"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20889486"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21625540"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22219199"}],"value":"The J domain is sufficient to interact with HSP70 (HSPA1A or HSPA1B) and activate its ATPase activity (PubMed:22219199). The J domain is also required for the HSP70-mediated and ubiquitin-dependent proteasomal degradation of proteins like ATXN3 (PubMed:21625540). The J domain is required to reduce PRKN cytoplasmic aggregation (PubMed:20889486)"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15936278"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20889486"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21625540"}],"value":"The UIM domains mediate interaction with ubiquitinated chaperone clients and with the proteasome (PubMed:15936278). The UIM domains may have an opposite activity to the J domain, binding ubiquitinated proteins and protecting them from HSP70-mediated proteasomal degradation (PubMed:21625540). The UIM domains are not required to reduce PRKN cytoplasmic aggregation (PubMed:20889486)"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15936278"}],"value":"Ubiquitinated by STUB1; does not lead to proteasomal degradation"}],"commentType":"PTM"},{"commentType":"DISEASE","disease":{"diseaseId":"Neuronopathy, distal hereditary motor, autosomal recessive 5","diseaseAccession":"DI-03602","acronym":"HMNR5","description":"A form of distal hereditary motor neuronopathy, a heterogeneous group of neuromuscular disorders caused by selective degeneration of motor neurons in the anterior horn of the spinal cord, without sensory deficit in the posterior horn. The overall clinical picture consists of a classical distal muscular atrophy syndrome in the legs without clinical sensory loss. The disease starts with weakness and wasting of distal muscles of the anterior tibial and peroneal compartments of the legs. Later on, weakness and atrophy may expand to the proximal muscles of the lower limbs and/or to the distal upper limbs. HMNR5 is characterized by young adult onset of slowly progressive distal muscle weakness and atrophy resulting in gait impairment and loss of reflexes.","diseaseCrossReference":{"database":"MIM","id":"614881"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22522442"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24627108"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25274842"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Frameshift","sequence":"AAA09035.1","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Initiator methionine","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"Removed","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9QYI5"}]},{"type":"Chain","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":321,"modifier":"EXACT"}},"description":"DnaJ homolog subfamily B member 2","featureId":"PRO_0000071018"},{"type":"Propeptide","location":{"start":{"value":322,"modifier":"EXACT"},"end":{"value":324,"modifier":"EXACT"}},"description":"Removed in mature form","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"12754272"}],"featureId":"PRO_0000438687"},{"type":"Domain","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":71,"modifier":"EXACT"}},"description":"J","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00286"}]},{"type":"Domain","location":{"start":{"value":210,"modifier":"EXACT"},"end":{"value":226,"modifier":"EXACT"}},"description":"UIM 1","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00213"}]},{"type":"Domain","location":{"start":{"value":250,"modifier":"EXACT"},"end":{"value":269,"modifier":"EXACT"}},"description":"UIM 2","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00213"}]},{"type":"Region","location":{"start":{"value":70,"modifier":"EXACT"},"end":{"value":90,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":218,"modifier":"EXACT"},"end":{"value":324,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Motif","location":{"start":{"value":321,"modifier":"EXACT"},"end":{"value":324,"modifier":"EXACT"}},"description":"CAAX motif","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12754272"}]},{"type":"Compositional bias","location":{"start":{"value":224,"modifier":"EXACT"},"end":{"value":241,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":280,"modifier":"EXACT"},"end":{"value":289,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":303,"modifier":"EXACT"},"end":{"value":324,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":2,"modifier":"EXACT"}},"description":"N-acetylalanine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9QYI5"}]},{"type":"Modified residue","location":{"start":{"value":311,"modifier":"EXACT"},"end":{"value":311,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9QYI5"}]},{"type":"Modified residue","location":{"start":{"value":321,"modifier":"EXACT"},"end":{"value":321,"modifier":"EXACT"}},"description":"Cysteine methyl ester","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"12754272"}]},{"type":"Lipidation","location":{"start":{"value":321,"modifier":"EXACT"},"end":{"value":321,"modifier":"EXACT"}},"description":"S-geranylgeranyl cysteine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12754272"}]},{"type":"Alternative sequence","location":{"start":{"value":275,"modifier":"EXACT"},"end":{"value":277,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_001286","alternativeSequence":{"originalSequence":"GGR","alternativeSequences":["DVF"]}},{"type":"Alternative sequence","location":{"start":{"value":278,"modifier":"EXACT"},"end":{"value":324,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_001287","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":5,"modifier":"EXACT"},"end":{"value":5,"modifier":"EXACT"}},"description":"in HMNR5; dbSNP:rs730882140","featureCrossReferences":[{"database":"dbSNP","id":"rs730882140"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24627108"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25274842"}],"featureId":"VAR_073286","alternativeSequence":{"originalSequence":"Y","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":270,"modifier":"EXACT"},"end":{"value":270,"modifier":"EXACT"}},"description":"in dbSNP:rs34127289","featureCrossReferences":[{"database":"dbSNP","id":"rs34127289"}],"featureId":"VAR_048910","alternativeSequence":{"originalSequence":"G","alternativeSequences":["R"]}},{"type":"Mutagenesis","location":{"start":{"value":31,"modifier":"EXACT"},"end":{"value":33,"modifier":"EXACT"}},"description":"Loss of interaction with HSP70 and loss of the ability to promote ATXN3 proteasomal degradation.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21625540"}],"alternativeSequence":{"originalSequence":"HPD","alternativeSequences":["QPN"]}},{"type":"Mutagenesis","location":{"start":{"value":31,"modifier":"EXACT"},"end":{"value":31,"modifier":"EXACT"}},"description":"Probable loss of interaction with HSP70 and loss of the ability to reduce PRKN aggregation.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12754272"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20889486"}],"alternativeSequence":{"originalSequence":"H","alternativeSequences":["Q"]}},{"type":"Mutagenesis","location":{"start":{"value":219,"modifier":"EXACT"},"end":{"value":219,"modifier":"EXACT"}},"description":"Loss of interaction with polyubiquitin chains, loss of interaction with PSMA3, and loss of the ability to protect ATXN3 from proteasomal degradation; when associated with A-222; A-262 and A-265.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15936278"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21625540"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":222,"modifier":"EXACT"},"end":{"value":222,"modifier":"EXACT"}},"description":"Loss of interaction with polyubiquitin chains, loss of interaction with PSMA3, and loss of the ability to protect ATXN3 from proteasomal degradation; when associated with A-219; A-262 and A-265.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15936278"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21625540"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":262,"modifier":"EXACT"},"end":{"value":262,"modifier":"EXACT"}},"description":"Loss of interaction with polyubiquitin chains, loss of interaction with PSMA3, and loss of the ability to protect ATXN3 from proteasomal degradation; when associated with A-219; A-222 and A-265.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15936278"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21625540"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":265,"modifier":"EXACT"},"end":{"value":265,"modifier":"EXACT"}},"description":"Loss of interaction with polyubiquitin chains, loss of interaction with PSMA3, and loss of the ability to protect ATXN3 from proteasomal degradation; when associated with A-219; A-222 and A-262.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15936278"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21625540"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":321,"modifier":"EXACT"},"end":{"value":321,"modifier":"EXACT"}},"description":"Loss of localization to the endoplasmic reticulum and relocalization to cytoplasm and nucleus.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12754272"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["S"]}},{"type":"Mutagenesis","location":{"start":{"value":324,"modifier":"EXACT"},"end":{"value":324,"modifier":"EXACT"}},"description":"No effect on localization to the endoplasmic reticulum membrane.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12754272"}],"alternativeSequence":{"originalSequence":"L","alternativeSequences":["M"]}},{"type":"Sequence conflict","location":{"start":{"value":214,"modifier":"EXACT"},"end":{"value":214,"modifier":"EXACT"}},"description":"in Ref. 1; AAA09034/AAA09035","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"L","alternativeSequences":["R"]}},{"type":"Helix","location":{"start":{"value":4,"modifier":"EXACT"},"end":{"value":7,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2LGW"}]},{"type":"Beta strand","location":{"start":{"value":8,"modifier":"EXACT"},"end":{"value":10,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2LGW"}]},{"type":"Helix","location":{"start":{"value":16,"modifier":"EXACT"},"end":{"value":29,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2LGW"}]},{"type":"Turn","location":{"start":{"value":32,"modifier":"EXACT"},"end":{"value":34,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2LGW"}]},{"type":"Helix","location":{"start":{"value":40,"modifier":"EXACT"},"end":{"value":57,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2LGW"}]},{"type":"Helix","location":{"start":{"value":59,"modifier":"EXACT"},"end":{"value":70,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2LGW"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0007","category":"PTM","name":"Acetylation"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0143","category":"Molecular function","name":"Chaperone"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0256","category":"Cellular component","name":"Endoplasmic reticulum"},{"id":"KW-0449","category":"PTM","name":"Lipoprotein"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0488","category":"PTM","name":"Methylation"},{"id":"KW-0523","category":"Disease","name":"Neurodegeneration"},{"id":"KW-0622","category":"Disease","name":"Neuropathy"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-0636","category":"PTM","name":"Prenylation"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0677","category":"Domain","name":"Repeat"},{"id":"KW-0832","category":"PTM","name":"Ubl conjugation"}],"references":[{"referenceNumber":1,"citation":{"id":"1599432","citationType":"journal article","authors":["Cheetham M.E.","Brion J.-P.","Anderton B.H."],"citationCrossReferences":[{"database":"PubMed","id":"1599432"},{"database":"DOI","id":"10.1042/bj2840469"}],"title":"Human homologues of the bacterial heat-shock protein DnaJ are preferentially expressed in neurons.","publicationDate":"1992","journal":"Biochem. J.","firstPage":"469","lastPage":"476","volume":"284"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2)","TISSUE SPECIFICITY"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"CI-BI1V1L31OBJQH","citationType":"submission","authors":["Cheetham M.E."],"publicationDate":"JUL-1998","submissionDatabase":"UniProtKB"},"referencePositions":["SEQUENCE REVISION TO 214"]},{"referenceNumber":3,"citation":{"id":"CI-4IUTJLP3044AK","citationType":"submission","authors":["Kalnine N.","Chen X.","Rolfs A.","Halleck A.","Hines L.","Eisenstein S.","Koundinya M.","Raphael J.","Moreira D.","Kelley T.","LaBaer J.","Lin Y.","Phelan M.","Farmer A."],"title":"Cloning of human full-length CDSs in BD Creator(TM) system donor vector.","publicationDate":"MAY-2003","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"]},{"referenceNumber":4,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)"],"referenceComments":[{"value":"Brain","type":"TISSUE"},{"value":"Lung","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"15815621","citationType":"journal article","authors":["Hillier L.W.","Graves T.A.","Fulton R.S.","Fulton L.A.","Pepin K.H.","Minx P.","Wagner-McPherson C.","Layman D.","Wylie K.","Sekhon M.","Becker M.C.","Fewell G.A.","Delehaunty K.D.","Miner T.L.","Nash W.E.","Kremitzki C.","Oddy L.","Du H.","Sun H.","Bradshaw-Cordum H.","Ali J.","Carter J.","Cordes M.","Harris A.","Isak A.","van Brunt A.","Nguyen C.","Du F.","Courtney L.","Kalicki J.","Ozersky P.","Abbott S.","Armstrong J.","Belter E.A.","Caruso L.","Cedroni M.","Cotton M.","Davidson T.","Desai A.","Elliott G.","Erb T.","Fronick C.","Gaige T.","Haakenson W.","Haglund K.","Holmes A.","Harkins R.","Kim K.","Kruchowski S.S.","Strong C.M.","Grewal N.","Goyea E.","Hou S.","Levy A.","Martinka S.","Mead K.","McLellan M.D.","Meyer R.","Randall-Maher J.","Tomlinson C.","Dauphin-Kohlberg S.","Kozlowicz-Reilly A.","Shah N.","Swearengen-Shahid S.","Snider J.","Strong J.T.","Thompson J.","Yoakum M.","Leonard S.","Pearman C.","Trani L.","Radionenko M.","Waligorski J.E.","Wang C.","Rock S.M.","Tin-Wollam A.-M.","Maupin R.","Latreille P.","Wendl M.C.","Yang S.-P.","Pohl C.","Wallis J.W.","Spieth J.","Bieri T.A.","Berkowicz N.","Nelson J.O.","Osborne J.","Ding L.","Meyer R.","Sabo A.","Shotland Y.","Sinha P.","Wohldmann P.E.","Cook L.L.","Hickenbotham M.T.","Eldred J.","Williams D.","Jones T.A.","She X.","Ciccarelli F.D.","Izaurralde E.","Taylor J.","Schmutz J.","Myers R.M.","Cox D.R.","Huang X.","McPherson J.D.","Mardis E.R.","Clifton S.W.","Warren W.C.","Chinwalla A.T.","Eddy S.R.","Marra M.A.","Ovcharenko I.","Furey T.S.","Miller W.","Eichler E.E.","Bork P.","Suyama M.","Torrents D.","Waterston R.H.","Wilson R.K."],"citationCrossReferences":[{"database":"PubMed","id":"15815621"},{"database":"DOI","id":"10.1038/nature03466"}],"title":"Generation and annotation of the DNA sequences of human chromosomes 2 and 4.","publicationDate":"2005","journal":"Nature","firstPage":"724","lastPage":"731","volume":"434"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":6,"citation":{"id":"CI-5GBDQ6B103N1E","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"JUL-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":7,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)"],"referenceComments":[{"value":"Colon","type":"TISSUE"},{"value":"Lymph","type":"TISSUE"}]},{"referenceNumber":8,"citation":{"id":"7957263","citationType":"journal article","authors":["Cheetham M.E.","Jackson A.P.","Anderton B.H."],"citationCrossReferences":[{"database":"PubMed","id":"7957263"},{"database":"DOI","id":"10.1111/j.1432-1033.1994.tb20030.x"}],"title":"Regulation of 70-kDa heat-shock-protein ATPase activity and substrate binding by human DnaJ-like proteins, HSJ1a and HSJ1b.","publicationDate":"1994","journal":"Eur. J. Biochem.","firstPage":"99","lastPage":"107","volume":"226"},"referencePositions":["FUNCTION"]},{"referenceNumber":9,"citation":{"id":"12754272","citationType":"journal article","authors":["Chapple J.P.","Cheetham M.E."],"citationCrossReferences":[{"database":"PubMed","id":"12754272"},{"database":"DOI","id":"10.1074/jbc.m212349200"}],"title":"The chaperone environment at the cytoplasmic face of the endoplasmic reticulum can modulate rhodopsin processing and inclusion formation.","publicationDate":"2003","journal":"J. Biol. Chem.","firstPage":"19087","lastPage":"19094","volume":"278"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION (ISOFORMS 1 AND 2)","TOPOLOGY (ISOFORM 1)","TISSUE SPECIFICITY (ISOFORMS 1 AND 2)","MUTAGENESIS OF HIS-31; CYS-321 AND LEU-324","ISOPRENYLATION AT CYS-321","METHYLATION AT CYS-321","MOTIF"]},{"referenceNumber":10,"citation":{"id":"15936278","citationType":"journal article","authors":["Westhoff B.","Chapple J.P.","van der Spuy J.","Hoehfeld J.","Cheetham M.E."],"citationCrossReferences":[{"database":"PubMed","id":"15936278"},{"database":"DOI","id":"10.1016/j.cub.2005.04.058"}],"title":"HSJ1 is a neuronal shuttling factor for the sorting of chaperone clients to the proteasome.","publicationDate":"2005","journal":"Curr. Biol.","firstPage":"1058","lastPage":"1064","volume":"15"},"referencePositions":["FUNCTION","INTERACTION WITH HSPA8 AND PSMA3","UBIQUITINATION BY STUB1","DOMAIN","MUTAGENESIS OF 31-HIS--ASP-33; SER-219; GLU-222; SER-262 AND GLU-265"]},{"referenceNumber":11,"citation":{"id":"20889486","citationType":"journal article","authors":["Rose J.M.","Novoselov S.S.","Robinson P.A.","Cheetham M.E."],"citationCrossReferences":[{"database":"PubMed","id":"20889486"},{"database":"DOI","id":"10.1093/hmg/ddq428"}],"title":"Molecular chaperone-mediated rescue of mitophagy by a Parkin RING1 domain mutant.","publicationDate":"2011","journal":"Hum. Mol. Genet.","firstPage":"16","lastPage":"27","volume":"20"},"referencePositions":["FUNCTION","DOMAIN","MUTAGENESIS OF HIS-31"]},{"referenceNumber":12,"citation":{"id":"21719532","citationType":"journal article","authors":["Meimaridou E.","Gooljar S.B.","Ramnarace N.","Anthonypillai L.","Clark A.J.","Chapple J.P."],"citationCrossReferences":[{"database":"PubMed","id":"21719532"},{"database":"DOI","id":"10.1210/me.2011-1020"}],"title":"The cytosolic chaperone Hsc70 promotes traffic to the cell surface of intracellular retained melanocortin-4 receptor mutants.","publicationDate":"2011","journal":"Mol. Endocrinol.","firstPage":"1650","lastPage":"1660","volume":"25"},"referencePositions":["FUNCTION"]},{"referenceNumber":13,"citation":{"id":"21625540","citationType":"journal article","authors":["Gao X.C.","Zhou C.J.","Zhou Z.R.","Zhang Y.H.","Zheng X.M.","Song A.X.","Hu H.Y."],"citationCrossReferences":[{"database":"PubMed","id":"21625540"},{"database":"DOI","id":"10.1371/journal.pone.0019763"}],"title":"Co-chaperone HSJ1a dually regulates the proteasomal degradation of ataxin-3.","publicationDate":"2011","journal":"PLoS ONE","firstPage":"E19763","lastPage":"E19763","volume":"6"},"referencePositions":["FUNCTION","INTERACTION WITH HSP70","SUBCELLULAR LOCATION","DOMAIN","MUTAGENESIS OF 31-HIS--ASP-33; SER-219; GLU-222; SER-262 AND GLU-265"]},{"referenceNumber":14,"citation":{"id":"22522442","citationType":"journal article","authors":["Blumen S.C.","Astord S.","Robin V.","Vignaud L.","Toumi N.","Cieslik A.","Achiron A.","Carasso R.L.","Gurevich M.","Braverman I.","Blumen N.","Munich A.","Barkats M.","Viollet L."],"citationCrossReferences":[{"database":"PubMed","id":"22522442"},{"database":"DOI","id":"10.1002/ana.22684"}],"title":"A rare recessive distal hereditary motor neuropathy with HSJ1 chaperone mutation.","publicationDate":"2012","journal":"Ann. Neurol.","firstPage":"509","lastPage":"519","volume":"71"},"referencePositions":["INVOLVEMENT IN HMNR5"]},{"referenceNumber":15,"citation":{"id":"22396390","citationType":"journal article","authors":["Labbadia J.","Novoselov S.S.","Bett J.S.","Weiss A.","Paganetti P.","Bates G.P.","Cheetham M.E."],"citationCrossReferences":[{"database":"PubMed","id":"22396390"},{"database":"DOI","id":"10.1093/brain/aws022"}],"title":"Suppression of protein aggregation by chaperone modification of high molecular weight complexes.","publicationDate":"2012","journal":"Brain","firstPage":"1180","lastPage":"1196","volume":"135"},"referencePositions":["FUNCTION"]},{"referenceNumber":16,"citation":{"id":"24023695","citationType":"journal article","authors":["Novoselov S.S.","Mustill W.J.","Gray A.L.","Dick J.R.","Kanuga N.","Kalmar B.","Greensmith L.","Cheetham M.E."],"citationCrossReferences":[{"database":"PubMed","id":"24023695"},{"database":"DOI","id":"10.1371/journal.pone.0073944"}],"title":"Molecular chaperone mediated late-stage neuroprotection in the SOD1(G93A) mouse model of amyotrophic lateral sclerosis.","publicationDate":"2013","journal":"PLoS ONE","firstPage":"E73944","lastPage":"E73944","volume":"8"},"referencePositions":["FUNCTION"]},{"referenceNumber":17,"citation":{"id":"24627108","citationType":"journal article","authors":["Schabhuettl M.","Wieland T.","Senderek J.","Baets J.","Timmerman V.","De Jonghe P.","Reilly M.M.","Stieglbauer K.","Laich E.","Windhager R.","Erwa W.","Trajanoski S.","Strom T.M.","Auer-Grumbach M."],"citationCrossReferences":[{"database":"PubMed","id":"24627108"},{"database":"DOI","id":"10.1007/s00415-014-7289-8"}],"title":"Whole-exome sequencing in patients with inherited neuropathies: outcome and challenges.","publicationDate":"2014","journal":"J. Neurol.","firstPage":"970","lastPage":"982","volume":"261"},"referencePositions":["INVOLVEMENT IN HMNR5","VARIANT HMNR5 CYS-5"]},{"referenceNumber":18,"citation":{"id":"25274842","citationType":"journal article","authors":["Gess B.","Auer-Grumbach M.","Schirmacher A.","Strom T.","Zitzelsberger M.","Rudnik-Schoneborn S.","Rohr D.","Halfter H.","Young P.","Senderek J."],"citationCrossReferences":[{"database":"PubMed","id":"25274842"},{"database":"DOI","id":"10.1212/wnl.0000000000000966"}],"title":"HSJ1-related hereditary neuropathies: novel mutations and extended clinical spectrum.","publicationDate":"2014","journal":"Neurology","firstPage":"1726","lastPage":"1732","volume":"83"},"referencePositions":["INVOLVEMENT IN HMNR5","VARIANT HMNR5 CYS-5"]},{"referenceNumber":19,"citation":{"id":"22219199","citationType":"journal article","authors":["Gao X.C.","Zhou C.J.","Zhou Z.R.","Wu M.","Cao C.Y.","Hu H.Y."],"citationCrossReferences":[{"database":"PubMed","id":"22219199"},{"database":"DOI","id":"10.1074/jbc.m111.294728"}],"title":"The C-terminal helices of heat shock protein 70 are essential for J-domain binding and ATPase activation.","publicationDate":"2012","journal":"J. Biol. Chem.","firstPage":"6044","lastPage":"6052","volume":"287"},"referencePositions":["STRUCTURE BY NMR OF 1-71","FUNCTION","INTERACTION WITH HSP70","DOMAIN"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"S37375","properties":[{"key":"ProteinId","value":"AAA09034.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"S37374","properties":[{"key":"ProteinId","value":"AAA09035.1"},{"key":"Status","value":"ALT_FRAME"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"X63368","properties":[{"key":"ProteinId","value":"CAA44968.2"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"X63368","properties":[{"key":"ProteinId","value":"CAA44969.2"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BT007088","properties":[{"key":"ProteinId","value":"AAP35751.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK292761","properties":[{"key":"ProteinId","value":"BAF85450.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK312723","properties":[{"key":"ProteinId","value":"BAG35597.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AC114803","properties":[{"key":"ProteinId","value":"AAY24037.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471063","properties":[{"key":"ProteinId","value":"EAW70722.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC011609","properties":[{"key":"ProteinId","value":"AAH11609.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC047056","properties":[{"key":"ProteinId","value":"AAH47056.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS2439.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P25686-3"},{"database":"CCDS","id":"CCDS46519.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P25686-2"},{"database":"PIR","id":"S23508","properties":[{"key":"EntryName","value":"S23508"}]},{"database":"RefSeq","id":"NP_001034639.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001039550.2"}],"isoformId":"P25686-2"},{"database":"RefSeq","id":"NP_006727.2","properties":[{"key":"NucleotideSequenceId","value":"NM_006736.6"}],"isoformId":"P25686-3"},{"database":"PDB","id":"2LGW","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=1-91"}]},{"database":"PDBsum","id":"2LGW","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"P25686","properties":[{"key":"Description","value":"-"}]},{"database":"BMRB","id":"P25686","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P25686","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"109533","properties":[{"key":"Interactions","value":"132"}]},{"database":"CORUM","id":"P25686","properties":[{"key":"Description","value":"-"}]},{"database":"DIP","id":"DIP-29051N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P25686","properties":[{"key":"Number of interactors","value":"1988"}]},{"database":"IntAct","id":"P25686","properties":[{"key":"Interactions","value":"110"}]},{"database":"MINT","id":"P25686","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"MUSIC2-C5188-DNAJB2","properties":[{"key":"Evidences","value":"Osteosarcoma (U2OS) cell map - Nuclear envelope and nucleocytoplasmic transport (49 proteins)"}]},{"database":"STRING","id":"9606.ENSP00000338019","properties":[{"key":"Description","value":"-"}]},{"database":"GlyCosmos","id":"P25686","properties":[{"key":"glycosylation","value":"1 site, 1 glycan"}]},{"database":"GlyGen","id":"P25686","properties":[{"key":"glycosylation","value":"1 site, 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"P25686","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"P25686","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"DNAJB2","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"158518384","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"P25686","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"P25686","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000338019","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P25686","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"54281","properties":[{"key":"Description","value":"-"}],"isoformId":"P25686-3"},{"database":"ProteomicsDB","id":"54282","properties":[{"key":"Description","value":"-"}],"isoformId":"P25686-2"},{"database":"Pumba","id":"P25686","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"34321","properties":[{"key":"antibodies","value":"365 antibodies from 33 providers"}]},{"database":"DNASU","id":"3300","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000336576.10","properties":[{"key":"ProteinId","value":"ENSP00000338019.5"},{"key":"GeneId","value":"ENSG00000135924.18"}],"isoformId":"P25686-3"},{"database":"Ensembl","id":"ENST00000392086.8","properties":[{"key":"ProteinId","value":"ENSP00000375936.4"},{"key":"GeneId","value":"ENSG00000135924.18"}],"isoformId":"P25686-2"},{"database":"Ensembl","id":"ENST00000933785.1","properties":[{"key":"ProteinId","value":"ENSP00000603844.1"},{"key":"GeneId","value":"ENSG00000135924.18"}],"isoformId":"P25686-3"},{"database":"GeneID","id":"3300","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:3300","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000336576.10","properties":[{"key":"ProteinId","value":"ENSP00000338019.5"},{"key":"RefSeqNucleotideId","value":"NM_006736.6"},{"key":"RefSeqProteinId","value":"NP_006727.2"}]},{"database":"UCSC","id":"uc002vkw.2","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"P25686-3"},{"database":"UCSC","id":"uc002vkx.2","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:5228","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA27415","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"3300","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"3300","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"DNAJB2","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:5228","properties":[{"key":"GeneName","value":"DNAJB2"}]},{"database":"HPA","id":"ENSG00000135924","properties":[{"key":"ExpressionPatterns","value":"Tissue enhanced (brain)"}]},{"database":"MalaCards","id":"DNAJB2","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"604139","properties":[{"key":"Type","value":"gene"}]},{"database":"MIM","id":"614881","properties":[{"key":"Type","value":"phenotype"}]},{"database":"OpenTargets","id":"ENSG00000135924","properties":[{"key":"Description","value":"-"}]},{"database":"Orphanet","id":"443950","properties":[{"key":"Disease","value":"DNAJB2-related Charcot-Marie-Tooth disease type 2"}]},{"database":"Orphanet","id":"314485","properties":[{"key":"Disease","value":"Young adult-onset distal hereditary motor neuropathy"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000135924","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG0714","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000160220","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P25686","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"HHRAGVF","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"10250354at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"P25686","properties":[{"key":"Number of GO annotations","value":"5 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"P25686","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"P25686","properties":[{"key":"Description","value":"-"}]},{"database":"SignaLink","id":"P25686","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000135924","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"3300","properties":[{"key":"hits","value":"24 hits in 1158 CRISPR screens"}]},{"database":"CD-CODE","id":"FB4E32DD","properties":[{"key":"EntryName","value":"Presynaptic clusters and postsynaptic densities"}]},{"database":"ChiTaRS","id":"DNAJB2","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"P25686","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"DNAJB2","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"3300","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"P25686","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:P25686","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 2"}]},{"database":"RNAct","id":"P25686","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000135924","properties":[{"key":"ExpressionPatterns","value":"Expressed in C1 segment of cervical spinal cord and 201 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"P25686","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12754272"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21625540"}]},{"database":"GO","id":"GO:0098554","properties":[{"key":"GoTerm","value":"C:cytoplasmic side of endoplasmic reticulum membrane"},{"key":"GoEvidenceType","value":"TAS:ARUK-UCL"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"21231916"}]},{"database":"GO","id":"GO:0005789","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum membrane"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12754272"}]},{"database":"GO","id":"GO:0016234","properties":[{"key":"GoTerm","value":"C:inclusion body"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}]},{"database":"GO","id":"GO:0031965","properties":[{"key":"GoTerm","value":"C:nuclear membrane"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"21231916"}]},{"database":"GO","id":"GO:0048471","properties":[{"key":"GoTerm","value":"C:perinuclear region of cytoplasm"},{"key":"GoEvidenceType","value":"IDA:ARUK-UCL"}]},{"database":"GO","id":"GO:0000502","properties":[{"key":"GoTerm","value":"C:proteasome complex"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}]},{"database":"GO","id":"GO:0001671","properties":[{"key":"GoTerm","value":"F:ATPase activator activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22219199"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"7957263"}]},{"database":"GO","id":"GO:0030544","properties":[{"key":"GoTerm","value":"F:Hsp70 protein binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"22219199"}]},{"database":"GO","id":"GO:0031593","properties":[{"key":"GoTerm","value":"F:polyubiquitin modification-dependent protein binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}]},{"database":"GO","id":"GO:0070628","properties":[{"key":"GoTerm","value":"F:proteasome binding"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}]},{"database":"GO","id":"GO:0120283","properties":[{"key":"GoTerm","value":"F:protein serine/threonine kinase binding"},{"key":"GoEvidenceType","value":"IPI:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"28031292"}]},{"database":"GO","id":"GO:0051087","properties":[{"key":"GoTerm","value":"F:protein-folding chaperone binding"},{"key":"GoEvidenceType","value":"IPI:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"21231916"}]},{"database":"GO","id":"GO:0043130","properties":[{"key":"GoTerm","value":"F:ubiquitin binding"},{"key":"GoEvidenceType","value":"IDA:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"28031292"}]},{"database":"GO","id":"GO:0031625","properties":[{"key":"GoTerm","value":"F:ubiquitin protein ligase binding"},{"key":"GoEvidenceType","value":"IPI:ParkinsonsUK-UCL"}]},{"database":"GO","id":"GO:0140036","properties":[{"key":"GoTerm","value":"F:ubiquitin-modified protein reader activity"},{"key":"GoEvidenceType","value":"IDA:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"28031292"}]},{"database":"GO","id":"GO:0036503","properties":[{"key":"GoTerm","value":"P:ERAD pathway"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}]},{"database":"GO","id":"GO:0030308","properties":[{"key":"GoTerm","value":"P:negative regulation of cell growth"},{"key":"GoEvidenceType","value":"IGI:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"9553041"}]},{"database":"GO","id":"GO:0008285","properties":[{"key":"GoTerm","value":"P:negative regulation of cell population proliferation"},{"key":"GoEvidenceType","value":"IGI:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"9553041"}]},{"database":"GO","id":"GO:0090084","properties":[{"key":"GoTerm","value":"P:negative regulation of inclusion body assembly"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"21231916"}]},{"database":"GO","id":"GO:0032091","properties":[{"key":"GoTerm","value":"P:negative regulation of protein binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"7957263"}]},{"database":"GO","id":"GO:0090086","properties":[{"key":"GoTerm","value":"P:negative regulation of protein deubiquitination"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}]},{"database":"GO","id":"GO:0070050","properties":[{"key":"GoTerm","value":"P:neuron cellular homeostasis"},{"key":"GoEvidenceType","value":"TAS:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"28031292"}]},{"database":"GO","id":"GO:0032781","properties":[{"key":"GoTerm","value":"P:positive regulation of ATP-dependent activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22219199"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"7957263"}]},{"database":"GO","id":"GO:0032436","properties":[{"key":"GoTerm","value":"P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"28031292"}]},{"database":"GO","id":"GO:0031398","properties":[{"key":"GoTerm","value":"P:positive regulation of protein ubiquitination"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}]},{"database":"GO","id":"GO:0043161","properties":[{"key":"GoTerm","value":"P:proteasome-mediated ubiquitin-dependent protein catabolic process"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}]},{"database":"GO","id":"GO:0006457","properties":[{"key":"GoTerm","value":"P:protein folding"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"24023695"}]},{"database":"GO","id":"GO:0042026","properties":[{"key":"GoTerm","value":"P:protein refolding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"21231916"}]},{"database":"GO","id":"GO:1903332","properties":[{"key":"GoTerm","value":"P:regulation of protein folding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"7957263"}]},{"database":"GO","id":"GO:0032880","properties":[{"key":"GoTerm","value":"P:regulation of protein localization"},{"key":"GoEvidenceType","value":"IMP:ParkinsonsUK-UCL"}]},{"database":"GO","id":"GO:0031396","properties":[{"key":"GoTerm","value":"P:regulation of protein ubiquitination"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"24023695"}]},{"database":"GO","id":"GO:0006986","properties":[{"key":"GoTerm","value":"P:response to unfolded protein"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"1599432"}]},{"database":"CDD","id":"cd06257","properties":[{"key":"EntryName","value":"DnaJ"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.287.110:FF:000021","properties":[{"key":"EntryName","value":"DnaJ (Hsp40) homolog, subfamily B, member 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"6.10.140.100","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.287.110","properties":[{"key":"EntryName","value":"DnaJ domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001623","properties":[{"key":"EntryName","value":"DnaJ_domain"}]},{"database":"InterPro","id":"IPR018253","properties":[{"key":"EntryName","value":"DnaJ_domain_CS"}]},{"database":"InterPro","id":"IPR043183","properties":[{"key":"EntryName","value":"DNJB2/6-like"}]},{"database":"InterPro","id":"IPR036869","properties":[{"key":"EntryName","value":"J_dom_sf"}]},{"database":"InterPro","id":"IPR003903","properties":[{"key":"EntryName","value":"UIM_dom"}]},{"database":"PANTHER","id":"PTHR45168","properties":[{"key":"EntryName","value":"DNAJ HOMOLOG SUBFAMILY B MEMBER 2"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR45168:SF1","properties":[{"key":"EntryName","value":"DNAJ HOMOLOG SUBFAMILY B MEMBER 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00226","properties":[{"key":"EntryName","value":"DnaJ"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00625","properties":[{"key":"EntryName","value":"JDOMAIN"}]},{"database":"SMART","id":"SM00271","properties":[{"key":"EntryName","value":"DnaJ"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00726","properties":[{"key":"EntryName","value":"UIM"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF46565","properties":[{"key":"EntryName","value":"Chaperone J-domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00636","properties":[{"key":"EntryName","value":"DNAJ_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50076","properties":[{"key":"EntryName","value":"DNAJ_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50330","properties":[{"key":"EntryName","value":"UIM"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MASYYEILDVPRSASADDIKKAYRRKALQWHPDKNPDNKEFAEKKFKEVAEAYEVLSDKHKREIYDRYGREGLTGTGTGPSRAEAGSGGPGFTFTFRSPEEVFREFFGSGDPFAELFDDLGPFSELQNRGSRHSGPFFTFSSSFPGHSDFSSSSFSFSPGAGAFRSVSTSTTFVQGRRITTRRIMENGQERVEVEEDGQLKSVTINGVPDDLALGLELSRREQQPSVTSRSGGTQVQQTPASCPLDSDLSEDEDLQLAMAYSLSEMEAAGKKPAGGREAQHRRQGRPKAQHQDPGLGGTQEGARGEATKRSPSPEEKASRCLIL","length":324,"molWeight":35580,"crc64":"0154ED3E29F34B4A","md5":"FF04FFC8C82CF01E09F05A9FC0C91EAF"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"INTERACTION":1,"SUBCELLULAR LOCATION":2,"ALTERNATIVE PRODUCTS":2,"TISSUE SPECIFICITY":1,"DOMAIN":2,"PTM":1,"DISEASE":1,"SEQUENCE CAUTION":1},"countByFeatureType":{"Initiator methionine":1,"Chain":1,"Propeptide":1,"Domain":3,"Region":2,"Motif":1,"Compositional bias":3,"Modified residue":3,"Lipidation":1,"Alternative sequence":2,"Natural variant":2,"Mutagenesis":8,"Sequence conflict":1,"Helix":4,"Beta strand":1,"Turn":1},"uniParcId":"UPI000000DCD8"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"C9JXB9","uniProtkbId":"C9JXB9_HUMAN","entryAudit":{"firstPublicDate":"2009-11-03","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2009-11-03","entryVersion":92,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000375937.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000375937.2"}],"value":"DnaJ heat shock protein family (Hsp40) member B2"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000375937.2"}],"value":"DNAJB2"}}],"features":[{"type":"Domain","location":{"start":{"value":3,"modifier":"EXACT"},"end":{"value":69,"modifier":"EXACT"}},"description":"J","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50076"}]},{"type":"Region","location":{"start":{"value":70,"modifier":"EXACT"},"end":{"value":90,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":187,"modifier":"EXACT"},"end":{"value":220,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":193,"modifier":"EXACT"},"end":{"value":210,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":244,"modifier":"EXACT"},"end":{"value":244,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000375937.2"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023186"}],"id":"KW-0143","category":"Molecular function","name":"Chaperone"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"C9JXB9"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"C9JXB9"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000375937.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000375937.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15815621","citationType":"journal article","authors":["Hillier L.W.","Graves T.A.","Fulton R.S.","Fulton L.A.","Pepin K.H.","Minx P.","Wagner-McPherson C.","Layman D.","Wylie K.","Sekhon M.","Becker M.C.","Fewell G.A.","Delehaunty K.D.","Miner T.L.","Nash W.E.","Kremitzki C.","Oddy L.","Du H.","Sun H.","Bradshaw-Cordum H.","Ali J.","Carter J.","Cordes M.","Harris A.","Isak A.","van Brunt A.","Nguyen C.","Du F.","Courtney L.","Kalicki J.","Ozersky P.","Abbott S.","Armstrong J.","Belter E.A.","Caruso L.","Cedroni M.","Cotton M.","Davidson T.","Desai A.","Elliott G.","Erb T.","Fronick C.","Gaige T.","Haakenson W.","Haglund K.","Holmes A.","Harkins R.","Kim K.","Kruchowski S.S.","Strong C.M.","Grewal N.","Goyea E.","Hou S.","Levy A.","Martinka S.","Mead K.","McLellan M.D.","Meyer R.","Randall-Maher J.","Tomlinson C.","Dauphin-Kohlberg S.","Kozlowicz-Reilly A.","Shah N.","Swearengen-Shahid S.","Snider J.","Strong J.T.","Thompson J.","Yoakum M.","Leonard S.","Pearman C.","Trani L.","Radionenko M.","Waligorski J.E.","Wang C.","Rock S.M.","Tin-Wollam A.M.","Maupin R.","Latreille P.","Wendl M.C.","Yang S.P.","Pohl C.","Wallis J.W.","Spieth J.","Bieri T.A.","Berkowicz N.","Nelson J.O.","Osborne J.","Ding L.","Meyer R.","Sabo A.","Shotland Y.","Sinha P.","Wohldmann P.E.","Cook L.L.","Hickenbotham M.T.","Eldred J.","Williams D.","Jones T.A.","She X.","Ciccarelli F.D.","Izaurralde E.","Taylor J.","Schmutz J.","Myers R.M.","Cox D.R.","Huang X.","McPherson J.D.","Mardis E.R.","Clifton S.W.","Warren W.C.","Chinwalla A.T.","Eddy S.R.","Marra M.A.","Ovcharenko I.","Furey T.S.","Miller W.","Eichler E.E.","Bork P.","Suyama M.","Torrents D.","Waterston R.H.","Wilson R.K."],"citationCrossReferences":[{"database":"PubMed","id":"15815621"},{"database":"DOI","id":"10.1038/nature03466"}],"title":"Generation and annotation of the DNA sequences of human chromosomes 2 and 4.","publicationDate":"2005","journal":"Nature","firstPage":"724","lastPage":"731","volume":"434"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000375937.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000375937.2"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC114803","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"C9JXB9","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"C9JXB9","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"C9JXB9","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"12102","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"34321","properties":[{"key":"antibodies","value":"365 antibodies from 33 providers"}]},{"database":"Ensembl","id":"ENST00000392087.6","properties":[{"key":"ProteinId","value":"ENSP00000375937.2"},{"key":"GeneId","value":"ENSG00000135924.18"}]},{"database":"UCSC","id":"uc061svi.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:5228","properties":[{"key":"GeneName","value":"DNAJB2"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000135924","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000160220","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"10250354at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"DNAJB2","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 2"}]},{"database":"Bgee","id":"ENSG00000135924","properties":[{"key":"ExpressionPatterns","value":"Expressed in C1 segment of cervical spinal cord and 201 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"C9JXB9","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0031965","properties":[{"key":"GoTerm","value":"C:nuclear membrane"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0030544","properties":[{"key":"GoTerm","value":"F:Hsp70 protein binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0090084","properties":[{"key":"GoTerm","value":"P:negative regulation of inclusion body assembly"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd06257","properties":[{"key":"EntryName","value":"DnaJ"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.287.110:FF:000021","properties":[{"key":"EntryName","value":"DnaJ (Hsp40) homolog, subfamily B, member 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"6.10.140.100","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.287.110","properties":[{"key":"EntryName","value":"DnaJ domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001623","properties":[{"key":"EntryName","value":"DnaJ_domain"}]},{"database":"InterPro","id":"IPR018253","properties":[{"key":"EntryName","value":"DnaJ_domain_CS"}]},{"database":"InterPro","id":"IPR043183","properties":[{"key":"EntryName","value":"DNJB2/6-like"}]},{"database":"InterPro","id":"IPR036869","properties":[{"key":"EntryName","value":"J_dom_sf"}]},{"database":"InterPro","id":"IPR003903","properties":[{"key":"EntryName","value":"UIM_dom"}]},{"database":"PANTHER","id":"PTHR45168","properties":[{"key":"EntryName","value":"DNAJ HOMOLOG SUBFAMILY B MEMBER 2"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR45168:SF1","properties":[{"key":"EntryName","value":"DNAJ HOMOLOG SUBFAMILY B MEMBER 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00226","properties":[{"key":"EntryName","value":"DnaJ"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00625","properties":[{"key":"EntryName","value":"JDOMAIN"}]},{"database":"SMART","id":"SM00271","properties":[{"key":"EntryName","value":"DnaJ"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00726","properties":[{"key":"EntryName","value":"UIM"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF46565","properties":[{"key":"EntryName","value":"Chaperone J-domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00636","properties":[{"key":"EntryName","value":"DNAJ_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50076","properties":[{"key":"EntryName","value":"DNAJ_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50330","properties":[{"key":"EntryName","value":"UIM"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MASYYEILDVPRSASADDIKKAYRRKALQWHPDKNPDNKEFAEKKFKEVAEAYEVLSDKHKREIYDRYGREGLTGTGTGPSRAEAGSGGPGFTFTFRSPEEVFREFFGSGDPFAELFDFSSSSFSFSPGAGAFRSVSTSTTFVQGRRITTRRIMENGQERVEVEEDGQLKSVTINGVPDDLALGLELSRREQQPSVTSRSGGTQVQQTPASCPLDSDLSEDEDLQLAMAYSLSEMEAAGKKPAG","length":244,"molWeight":26884,"crc64":"2C5D4CAF666F586A","md5":"711F2FD6FA47A0E4587C18332BB36C88"},"extraAttributes":{"countByFeatureType":{"Domain":1,"Region":2,"Compositional bias":1,"Non-terminal residue":1},"uniParcId":"UPI00018819A6"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"C9J1G2","uniProtkbId":"C9J1G2_HUMAN","entryAudit":{"firstPublicDate":"2009-11-03","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2009-11-03","entryVersion":96,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000392790.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000392790.1"}],"value":"DnaJ heat shock protein family (Hsp40) member B2"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000392790.1"}],"value":"DNAJB2"}}],"features":[{"type":"Domain","location":{"start":{"value":3,"modifier":"EXACT"},"end":{"value":69,"modifier":"EXACT"}},"description":"J","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50076"}]},{"type":"Region","location":{"start":{"value":70,"modifier":"EXACT"},"end":{"value":91,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":122,"modifier":"EXACT"},"end":{"value":122,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000392790.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023186"}],"id":"KW-0143","category":"Molecular function","name":"Chaperone"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"C9J1G2"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"C9J1G2"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000392790.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000392790.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15815621","citationType":"journal article","authors":["Hillier L.W.","Graves T.A.","Fulton R.S.","Fulton L.A.","Pepin K.H.","Minx P.","Wagner-McPherson C.","Layman D.","Wylie K.","Sekhon M.","Becker M.C.","Fewell G.A.","Delehaunty K.D.","Miner T.L.","Nash W.E.","Kremitzki C.","Oddy L.","Du H.","Sun H.","Bradshaw-Cordum H.","Ali J.","Carter J.","Cordes M.","Harris A.","Isak A.","van Brunt A.","Nguyen C.","Du F.","Courtney L.","Kalicki J.","Ozersky P.","Abbott S.","Armstrong J.","Belter E.A.","Caruso L.","Cedroni M.","Cotton M.","Davidson T.","Desai A.","Elliott G.","Erb T.","Fronick C.","Gaige T.","Haakenson W.","Haglund K.","Holmes A.","Harkins R.","Kim K.","Kruchowski S.S.","Strong C.M.","Grewal N.","Goyea E.","Hou S.","Levy A.","Martinka S.","Mead K.","McLellan M.D.","Meyer R.","Randall-Maher J.","Tomlinson C.","Dauphin-Kohlberg S.","Kozlowicz-Reilly A.","Shah N.","Swearengen-Shahid S.","Snider J.","Strong J.T.","Thompson J.","Yoakum M.","Leonard S.","Pearman C.","Trani L.","Radionenko M.","Waligorski J.E.","Wang C.","Rock S.M.","Tin-Wollam A.M.","Maupin R.","Latreille P.","Wendl M.C.","Yang S.P.","Pohl C.","Wallis J.W.","Spieth J.","Bieri T.A.","Berkowicz N.","Nelson J.O.","Osborne J.","Ding L.","Meyer R.","Sabo A.","Shotland Y.","Sinha P.","Wohldmann P.E.","Cook L.L.","Hickenbotham M.T.","Eldred J.","Williams D.","Jones T.A.","She X.","Ciccarelli F.D.","Izaurralde E.","Taylor J.","Schmutz J.","Myers R.M.","Cox D.R.","Huang X.","McPherson J.D.","Mardis E.R.","Clifton S.W.","Warren W.C.","Chinwalla A.T.","Eddy S.R.","Marra M.A.","Ovcharenko I.","Furey T.S.","Miller W.","Eichler E.E.","Bork P.","Suyama M.","Torrents D.","Waterston R.H.","Wilson R.K."],"citationCrossReferences":[{"database":"PubMed","id":"15815621"},{"database":"DOI","id":"10.1038/nature03466"}],"title":"Generation and annotation of the DNA sequences of human chromosomes 2 and 4.","publicationDate":"2005","journal":"Nature","firstPage":"724","lastPage":"731","volume":"434"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000392790.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000392790.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC114803","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"C9J1G2","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"C9J1G2","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"C9J1G2","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"8082","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"34321","properties":[{"key":"antibodies","value":"365 antibodies from 33 providers"}]},{"database":"Ensembl","id":"ENST00000442681.5","properties":[{"key":"ProteinId","value":"ENSP00000392790.1"},{"key":"GeneId","value":"ENSG00000135924.18"}]},{"database":"UCSC","id":"uc061svj.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:5228","properties":[{"key":"GeneName","value":"DNAJB2"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000135924","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000160220","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_017633_12_3_1","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"HHRAGVF","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"10250354at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"DNAJB2","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 2"}]},{"database":"Bgee","id":"ENSG00000135924","properties":[{"key":"ExpressionPatterns","value":"Expressed in C1 segment of cervical spinal cord and 201 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"C9J1G2","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0031965","properties":[{"key":"GoTerm","value":"C:nuclear membrane"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0030544","properties":[{"key":"GoTerm","value":"F:Hsp70 protein binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0090084","properties":[{"key":"GoTerm","value":"P:negative regulation of inclusion body assembly"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd06257","properties":[{"key":"EntryName","value":"DnaJ"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.287.110:FF:000021","properties":[{"key":"EntryName","value":"DnaJ (Hsp40) homolog, subfamily B, member 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.287.110","properties":[{"key":"EntryName","value":"DnaJ domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001623","properties":[{"key":"EntryName","value":"DnaJ_domain"}]},{"database":"InterPro","id":"IPR018253","properties":[{"key":"EntryName","value":"DnaJ_domain_CS"}]},{"database":"InterPro","id":"IPR043183","properties":[{"key":"EntryName","value":"DNJB2/6-like"}]},{"database":"InterPro","id":"IPR036869","properties":[{"key":"EntryName","value":"J_dom_sf"}]},{"database":"PANTHER","id":"PTHR45168","properties":[{"key":"EntryName","value":"DNAJ HOMOLOG SUBFAMILY B MEMBER 2"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR45168:SF1","properties":[{"key":"EntryName","value":"DNAJ HOMOLOG SUBFAMILY B MEMBER 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00226","properties":[{"key":"EntryName","value":"DnaJ"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00625","properties":[{"key":"EntryName","value":"JDOMAIN"}]},{"database":"SMART","id":"SM00271","properties":[{"key":"EntryName","value":"DnaJ"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF46565","properties":[{"key":"EntryName","value":"Chaperone J-domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00636","properties":[{"key":"EntryName","value":"DNAJ_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50076","properties":[{"key":"EntryName","value":"DNAJ_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MASYYEILDVPRSASADDIKKAYRRKALQWHPDKNPDNKEFAEKKFKEVAEAYEVLSDKHKREIYDRYGREGLTGTGTGPSRAEAGSGGPGFTFTFRSPEEVFREFFGSGDPFAELFDDLGP","length":122,"molWeight":13794,"crc64":"6B1BD111172485FB","md5":"86E79533D4837ED5D174072D4B8DDC32"},"extraAttributes":{"countByFeatureType":{"Domain":1,"Region":1,"Non-terminal residue":1},"uniParcId":"UPI000198C759"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"C9JRD2","uniProtkbId":"C9JRD2_HUMAN","entryAudit":{"firstPublicDate":"2009-11-03","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2009-11-03","entryVersion":96,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000414796.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000414796.1"}],"value":"DnaJ heat shock protein family (Hsp40) member B2"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000414796.1"}],"value":"DNAJB2"}}],"features":[{"type":"Domain","location":{"start":{"value":3,"modifier":"EXACT"},"end":{"value":69,"modifier":"EXACT"}},"description":"J","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50076"}]},{"type":"Region","location":{"start":{"value":70,"modifier":"EXACT"},"end":{"value":90,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":228,"modifier":"EXACT"},"end":{"value":228,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000414796.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023186"}],"id":"KW-0143","category":"Molecular function","name":"Chaperone"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"C9JRD2"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"C9JRD2"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000414796.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000414796.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15815621","citationType":"journal article","authors":["Hillier L.W.","Graves T.A.","Fulton R.S.","Fulton L.A.","Pepin K.H.","Minx P.","Wagner-McPherson C.","Layman D.","Wylie K.","Sekhon M.","Becker M.C.","Fewell G.A.","Delehaunty K.D.","Miner T.L.","Nash W.E.","Kremitzki C.","Oddy L.","Du H.","Sun H.","Bradshaw-Cordum H.","Ali J.","Carter J.","Cordes M.","Harris A.","Isak A.","van Brunt A.","Nguyen C.","Du F.","Courtney L.","Kalicki J.","Ozersky P.","Abbott S.","Armstrong J.","Belter E.A.","Caruso L.","Cedroni M.","Cotton M.","Davidson T.","Desai A.","Elliott G.","Erb T.","Fronick C.","Gaige T.","Haakenson W.","Haglund K.","Holmes A.","Harkins R.","Kim K.","Kruchowski S.S.","Strong C.M.","Grewal N.","Goyea E.","Hou S.","Levy A.","Martinka S.","Mead K.","McLellan M.D.","Meyer R.","Randall-Maher J.","Tomlinson C.","Dauphin-Kohlberg S.","Kozlowicz-Reilly A.","Shah N.","Swearengen-Shahid S.","Snider J.","Strong J.T.","Thompson J.","Yoakum M.","Leonard S.","Pearman C.","Trani L.","Radionenko M.","Waligorski J.E.","Wang C.","Rock S.M.","Tin-Wollam A.M.","Maupin R.","Latreille P.","Wendl M.C.","Yang S.P.","Pohl C.","Wallis J.W.","Spieth J.","Bieri T.A.","Berkowicz N.","Nelson J.O.","Osborne J.","Ding L.","Meyer R.","Sabo A.","Shotland Y.","Sinha P.","Wohldmann P.E.","Cook L.L.","Hickenbotham M.T.","Eldred J.","Williams D.","Jones T.A.","She X.","Ciccarelli F.D.","Izaurralde E.","Taylor J.","Schmutz J.","Myers R.M.","Cox D.R.","Huang X.","McPherson J.D.","Mardis E.R.","Clifton S.W.","Warren W.C.","Chinwalla A.T.","Eddy S.R.","Marra M.A.","Ovcharenko I.","Furey T.S.","Miller W.","Eichler E.E.","Bork P.","Suyama M.","Torrents D.","Waterston R.H.","Wilson R.K."],"citationCrossReferences":[{"database":"PubMed","id":"15815621"},{"database":"DOI","id":"10.1038/nature03466"}],"title":"Generation and annotation of the DNA sequences of human chromosomes 2 and 4.","publicationDate":"2005","journal":"Nature","firstPage":"724","lastPage":"731","volume":"434"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000414796.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000414796.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC114803","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"C9JRD2","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"C9JRD2","properties":[{"key":"Description","value":"-"}]},{"database":"IntAct","id":"C9JRD2","properties":[{"key":"Interactions","value":"1"}]},{"database":"SwissPalm","id":"C9JRD2","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"C9JRD2","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"11354","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"34321","properties":[{"key":"antibodies","value":"365 antibodies from 33 providers"}]},{"database":"Ensembl","id":"ENST00000425450.5","properties":[{"key":"ProteinId","value":"ENSP00000414796.1"},{"key":"GeneId","value":"ENSG00000135924.18"}]},{"database":"UCSC","id":"uc061sve.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:5228","properties":[{"key":"GeneName","value":"DNAJB2"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000135924","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000160220","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_017633_12_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"HHRAGVF","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"10250354at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"DNAJB2","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 2"}]},{"database":"Bgee","id":"ENSG00000135924","properties":[{"key":"ExpressionPatterns","value":"Expressed in C1 segment of cervical spinal cord and 201 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"C9JRD2","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0031965","properties":[{"key":"GoTerm","value":"C:nuclear membrane"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0030544","properties":[{"key":"GoTerm","value":"F:Hsp70 protein binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0090084","properties":[{"key":"GoTerm","value":"P:negative regulation of inclusion body assembly"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd06257","properties":[{"key":"EntryName","value":"DnaJ"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.287.110:FF:000021","properties":[{"key":"EntryName","value":"DnaJ (Hsp40) homolog, subfamily B, member 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.287.110","properties":[{"key":"EntryName","value":"DnaJ domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001623","properties":[{"key":"EntryName","value":"DnaJ_domain"}]},{"database":"InterPro","id":"IPR018253","properties":[{"key":"EntryName","value":"DnaJ_domain_CS"}]},{"database":"InterPro","id":"IPR043183","properties":[{"key":"EntryName","value":"DNJB2/6-like"}]},{"database":"InterPro","id":"IPR036869","properties":[{"key":"EntryName","value":"J_dom_sf"}]},{"database":"PANTHER","id":"PTHR45168","properties":[{"key":"EntryName","value":"DNAJ HOMOLOG SUBFAMILY B MEMBER 2"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR45168:SF1","properties":[{"key":"EntryName","value":"DNAJ HOMOLOG SUBFAMILY B MEMBER 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00226","properties":[{"key":"EntryName","value":"DnaJ"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00625","properties":[{"key":"EntryName","value":"JDOMAIN"}]},{"database":"SMART","id":"SM00271","properties":[{"key":"EntryName","value":"DnaJ"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF46565","properties":[{"key":"EntryName","value":"Chaperone J-domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00636","properties":[{"key":"EntryName","value":"DNAJ_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50076","properties":[{"key":"EntryName","value":"DNAJ_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MASYYEILDVPRSASADDIKKAYRRKALQWHPDKNPDNKEFAEKKFKEVAEAYEVLSDKHKREIYDRYGREGLTGTGTGPSRAEAGSGGPGFTFTFRSPEEVFREFFGSGDPFAELFDDLGPFSELQNRGSRHSGPFFTFSSSFPGHSDFSSSSFSFSPGAGAFRSVSTSTTFVQGRRITTRRIMENGQERVEVEEDGQLKSVTINGVPDDLALGLELSRREQQPSVT","length":228,"molWeight":25411,"crc64":"8BAEF3C80CCF2CD8","md5":"EF3073955DD68AF4FE114EFE36BED736"},"extraAttributes":{"countByFeatureType":{"Domain":1,"Region":1,"Non-terminal residue":1},"uniParcId":"UPI00018819A3"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"C9JX00","uniProtkbId":"C9JX00_HUMAN","entryAudit":{"firstPublicDate":"2009-11-03","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2009-11-03","entryVersion":96,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000387951.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000387951.1"}],"value":"DnaJ heat shock protein family (Hsp40) member B2"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000387951.1"}],"value":"DNAJB2"}}],"features":[{"type":"Domain","location":{"start":{"value":3,"modifier":"EXACT"},"end":{"value":69,"modifier":"EXACT"}},"description":"J","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50076"}]},{"type":"Region","location":{"start":{"value":70,"modifier":"EXACT"},"end":{"value":91,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":148,"modifier":"EXACT"},"end":{"value":148,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000387951.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023186"}],"id":"KW-0143","category":"Molecular function","name":"Chaperone"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"C9JX00"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"C9JX00"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000387951.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000387951.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15815621","citationType":"journal article","authors":["Hillier L.W.","Graves T.A.","Fulton R.S.","Fulton L.A.","Pepin K.H.","Minx P.","Wagner-McPherson C.","Layman D.","Wylie K.","Sekhon M.","Becker M.C.","Fewell G.A.","Delehaunty K.D.","Miner T.L.","Nash W.E.","Kremitzki C.","Oddy L.","Du H.","Sun H.","Bradshaw-Cordum H.","Ali J.","Carter J.","Cordes M.","Harris A.","Isak A.","van Brunt A.","Nguyen C.","Du F.","Courtney L.","Kalicki J.","Ozersky P.","Abbott S.","Armstrong J.","Belter E.A.","Caruso L.","Cedroni M.","Cotton M.","Davidson T.","Desai A.","Elliott G.","Erb T.","Fronick C.","Gaige T.","Haakenson W.","Haglund K.","Holmes A.","Harkins R.","Kim K.","Kruchowski S.S.","Strong C.M.","Grewal N.","Goyea E.","Hou S.","Levy A.","Martinka S.","Mead K.","McLellan M.D.","Meyer R.","Randall-Maher J.","Tomlinson C.","Dauphin-Kohlberg S.","Kozlowicz-Reilly A.","Shah N.","Swearengen-Shahid S.","Snider J.","Strong J.T.","Thompson J.","Yoakum M.","Leonard S.","Pearman C.","Trani L.","Radionenko M.","Waligorski J.E.","Wang C.","Rock S.M.","Tin-Wollam A.M.","Maupin R.","Latreille P.","Wendl M.C.","Yang S.P.","Pohl C.","Wallis J.W.","Spieth J.","Bieri T.A.","Berkowicz N.","Nelson J.O.","Osborne J.","Ding L.","Meyer R.","Sabo A.","Shotland Y.","Sinha P.","Wohldmann P.E.","Cook L.L.","Hickenbotham M.T.","Eldred J.","Williams D.","Jones T.A.","She X.","Ciccarelli F.D.","Izaurralde E.","Taylor J.","Schmutz J.","Myers R.M.","Cox D.R.","Huang X.","McPherson J.D.","Mardis E.R.","Clifton S.W.","Warren W.C.","Chinwalla A.T.","Eddy S.R.","Marra M.A.","Ovcharenko I.","Furey T.S.","Miller W.","Eichler E.E.","Bork P.","Suyama M.","Torrents D.","Waterston R.H.","Wilson R.K."],"citationCrossReferences":[{"database":"PubMed","id":"15815621"},{"database":"DOI","id":"10.1038/nature03466"}],"title":"Generation and annotation of the DNA sequences of human chromosomes 2 and 4.","publicationDate":"2005","journal":"Nature","firstPage":"724","lastPage":"731","volume":"434"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000387951.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000387951.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC114803","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"C9JX00","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"C9JX00","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"C9JX00","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"12059","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"34321","properties":[{"key":"antibodies","value":"365 antibodies from 33 providers"}]},{"database":"Ensembl","id":"ENST00000439026.1","properties":[{"key":"ProteinId","value":"ENSP00000387951.1"},{"key":"GeneId","value":"ENSG00000135924.18"}]},{"database":"UCSC","id":"uc061svk.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:5228","properties":[{"key":"GeneName","value":"DNAJB2"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000135924","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000160220","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"HHRAGVF","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"10250354at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"DNAJB2","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 2"}]},{"database":"Bgee","id":"ENSG00000135924","properties":[{"key":"ExpressionPatterns","value":"Expressed in C1 segment of cervical spinal cord and 201 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"C9JX00","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0031965","properties":[{"key":"GoTerm","value":"C:nuclear membrane"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0030544","properties":[{"key":"GoTerm","value":"F:Hsp70 protein binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0090084","properties":[{"key":"GoTerm","value":"P:negative regulation of inclusion body assembly"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd06257","properties":[{"key":"EntryName","value":"DnaJ"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.287.110:FF:000021","properties":[{"key":"EntryName","value":"DnaJ (Hsp40) homolog, subfamily B, member 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.287.110","properties":[{"key":"EntryName","value":"DnaJ domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001623","properties":[{"key":"EntryName","value":"DnaJ_domain"}]},{"database":"InterPro","id":"IPR018253","properties":[{"key":"EntryName","value":"DnaJ_domain_CS"}]},{"database":"InterPro","id":"IPR043183","properties":[{"key":"EntryName","value":"DNJB2/6-like"}]},{"database":"InterPro","id":"IPR036869","properties":[{"key":"EntryName","value":"J_dom_sf"}]},{"database":"PANTHER","id":"PTHR45168","properties":[{"key":"EntryName","value":"DNAJ HOMOLOG SUBFAMILY B MEMBER 2"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR45168:SF1","properties":[{"key":"EntryName","value":"DNAJ HOMOLOG SUBFAMILY B MEMBER 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00226","properties":[{"key":"EntryName","value":"DnaJ"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00625","properties":[{"key":"EntryName","value":"JDOMAIN"}]},{"database":"SMART","id":"SM00271","properties":[{"key":"EntryName","value":"DnaJ"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF46565","properties":[{"key":"EntryName","value":"Chaperone J-domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00636","properties":[{"key":"EntryName","value":"DNAJ_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50076","properties":[{"key":"EntryName","value":"DNAJ_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MASYYEILDVPRSASADDIKKAYRRKALQWHPDKNPDNKEFAEKKFKEVAEAYEVLSDKHKREIYDRYGREGLTGTGTGPSRAEAGSGGPGFTFTFRSPEEVFREFFGSGDPFAELFDDLGPFSELQNRGSRHSGPFFTFSSSFPGHS","length":148,"molWeight":16677,"crc64":"25B103B395C013B0","md5":"C160262E8FC2932ACAA390533F07336E"},"extraAttributes":{"countByFeatureType":{"Domain":1,"Region":1,"Non-terminal residue":1},"uniParcId":"UPI00018819A5"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"E7ETU0","uniProtkbId":"E7ETU0_HUMAN","entryAudit":{"firstPublicDate":"2011-03-08","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-03-08","entryVersion":85,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000395173.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000395173.1"}],"value":"DnaJ heat shock protein family (Hsp40) member B2"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000395173.1"}],"value":"DNAJB2"}}],"features":[{"type":"Domain","location":{"start":{"value":3,"modifier":"EXACT"},"end":{"value":69,"modifier":"EXACT"}},"description":"J","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50076"}]},{"type":"Region","location":{"start":{"value":70,"modifier":"EXACT"},"end":{"value":90,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":132,"modifier":"EXACT"},"end":{"value":132,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000395173.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023186"}],"id":"KW-0143","category":"Molecular function","name":"Chaperone"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"E7ETU0"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"E7ETU0"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000395173.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000395173.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15815621","citationType":"journal article","authors":["Hillier L.W.","Graves T.A.","Fulton R.S.","Fulton L.A.","Pepin K.H.","Minx P.","Wagner-McPherson C.","Layman D.","Wylie K.","Sekhon M.","Becker M.C.","Fewell G.A.","Delehaunty K.D.","Miner T.L.","Nash W.E.","Kremitzki C.","Oddy L.","Du H.","Sun H.","Bradshaw-Cordum H.","Ali J.","Carter J.","Cordes M.","Harris A.","Isak A.","van Brunt A.","Nguyen C.","Du F.","Courtney L.","Kalicki J.","Ozersky P.","Abbott S.","Armstrong J.","Belter E.A.","Caruso L.","Cedroni M.","Cotton M.","Davidson T.","Desai A.","Elliott G.","Erb T.","Fronick C.","Gaige T.","Haakenson W.","Haglund K.","Holmes A.","Harkins R.","Kim K.","Kruchowski S.S.","Strong C.M.","Grewal N.","Goyea E.","Hou S.","Levy A.","Martinka S.","Mead K.","McLellan M.D.","Meyer R.","Randall-Maher J.","Tomlinson C.","Dauphin-Kohlberg S.","Kozlowicz-Reilly A.","Shah N.","Swearengen-Shahid S.","Snider J.","Strong J.T.","Thompson J.","Yoakum M.","Leonard S.","Pearman C.","Trani L.","Radionenko M.","Waligorski J.E.","Wang C.","Rock S.M.","Tin-Wollam A.M.","Maupin R.","Latreille P.","Wendl M.C.","Yang S.P.","Pohl C.","Wallis J.W.","Spieth J.","Bieri T.A.","Berkowicz N.","Nelson J.O.","Osborne J.","Ding L.","Meyer R.","Sabo A.","Shotland Y.","Sinha P.","Wohldmann P.E.","Cook L.L.","Hickenbotham M.T.","Eldred J.","Williams D.","Jones T.A.","She X.","Ciccarelli F.D.","Izaurralde E.","Taylor J.","Schmutz J.","Myers R.M.","Cox D.R.","Huang X.","McPherson J.D.","Mardis E.R.","Clifton S.W.","Warren W.C.","Chinwalla A.T.","Eddy S.R.","Marra M.A.","Ovcharenko I.","Furey T.S.","Miller W.","Eichler E.E.","Bork P.","Suyama M.","Torrents D.","Waterston R.H.","Wilson R.K."],"citationCrossReferences":[{"database":"PubMed","id":"15815621"},{"database":"DOI","id":"10.1038/nature03466"}],"title":"Generation and annotation of the DNA sequences of human chromosomes 2 and 4.","publicationDate":"2005","journal":"Nature","firstPage":"724","lastPage":"731","volume":"434"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000395173.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000395173.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC114803","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"E7ETU0","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"E7ETU0","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"E7ETU0","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"18289","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"34321","properties":[{"key":"antibodies","value":"365 antibodies from 33 providers"}]},{"database":"Ensembl","id":"ENST00000421532.5","properties":[{"key":"ProteinId","value":"ENSP00000395173.1"},{"key":"GeneId","value":"ENSG00000135924.18"}]},{"database":"UCSC","id":"uc061svf.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:5228","properties":[{"key":"GeneName","value":"DNAJB2"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000135924","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000160220","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"10250354at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"DNAJB2","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 2"}]},{"database":"Bgee","id":"ENSG00000135924","properties":[{"key":"ExpressionPatterns","value":"Expressed in C1 segment of cervical spinal cord and 201 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"E7ETU0","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0031965","properties":[{"key":"GoTerm","value":"C:nuclear membrane"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0030544","properties":[{"key":"GoTerm","value":"F:Hsp70 protein binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0090084","properties":[{"key":"GoTerm","value":"P:negative regulation of inclusion body assembly"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd06257","properties":[{"key":"EntryName","value":"DnaJ"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.287.110:FF:000021","properties":[{"key":"EntryName","value":"DnaJ (Hsp40) homolog, subfamily B, member 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.287.110","properties":[{"key":"EntryName","value":"DnaJ domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001623","properties":[{"key":"EntryName","value":"DnaJ_domain"}]},{"database":"InterPro","id":"IPR018253","properties":[{"key":"EntryName","value":"DnaJ_domain_CS"}]},{"database":"InterPro","id":"IPR043183","properties":[{"key":"EntryName","value":"DNJB2/6-like"}]},{"database":"InterPro","id":"IPR036869","properties":[{"key":"EntryName","value":"J_dom_sf"}]},{"database":"PANTHER","id":"PTHR45168","properties":[{"key":"EntryName","value":"DNAJ HOMOLOG SUBFAMILY B MEMBER 2"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR45168:SF1","properties":[{"key":"EntryName","value":"DNAJ HOMOLOG SUBFAMILY B MEMBER 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00226","properties":[{"key":"EntryName","value":"DnaJ"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00625","properties":[{"key":"EntryName","value":"JDOMAIN"}]},{"database":"SMART","id":"SM00271","properties":[{"key":"EntryName","value":"DnaJ"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF46565","properties":[{"key":"EntryName","value":"Chaperone J-domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00636","properties":[{"key":"EntryName","value":"DNAJ_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50076","properties":[{"key":"EntryName","value":"DNAJ_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MASYYEILDVPRSASADDIKKAYRRKALQWHPDKNPDNKEFAEKKFKEVAEAYEVLSDKHKREIYDRYGREGLTGTGTGPSRAEAGSGGPGFTFTFRSPEEVFREFFGSGDPFAELFGEWTLEASEWLNFPL","length":132,"molWeight":15071,"crc64":"8A70E1FB3B2F92EA","md5":"CDDEEE4A3168334FDC883875CF9E0387"},"extraAttributes":{"countByFeatureType":{"Domain":1,"Region":1,"Non-terminal residue":1},"uniParcId":"UPI00018819A4"}}]}