{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q12959","secondaryAccessions":["A5YKK7","B4DGU1","B4DGZ8","B7ZMM0","B9EIQ5","D3DXB8","D3DXB9","E7EWL7","E9PG21","Q12958"],"uniProtkbId":"DLG1_HUMAN","entryAudit":{"firstPublicDate":"1997-11-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2009-02-10","entryVersion":257,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Disks large homolog 1"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"12445884"}],"value":"Synapse-associated protein 97"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"12445884"}],"value":"SAP-97"},{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"9192623"}],"value":"SAP97"}]},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"9192623"}],"value":"hDlg"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:2900"}],"value":"DLG1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A0A8C0TYJ0"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q811D0"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10656683"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12445884"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14699157"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15263016"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19213956"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20605917"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23676497"}],"value":"Essential multidomain scaffolding protein required for normal development (By similarity). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). May also play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel. During long-term depression in hippocampal neurons, it recruits ADAM10 to the plasma membrane (PubMed:23676497)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q62696"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q811D0"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10656683"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10779557"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10859302"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11602598"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12445884"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14699157"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15021905"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16519681"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16630835"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17237226"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17332497"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17980554"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19118189"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19213956"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20605917"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20702775"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23676497"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24503895"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25558062"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7477295"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7937897"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8638125"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8922391"},{"evidenceCode":"ECO:0000305"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"8757139"}],"value":"Homotetramer (Probable). Interacts (via guanylate kinase-like domain) with DLGAP1, DLGAP2, DLGAP3, DLGAP4 and MAP1A (By similarity). Interacts (via guanylate kinase-like domain) with KIF13B (PubMed:10859302). May interact with HTR2A (By similarity). Interacts (via PDZ domains) with GRIA1 (By similarity). Interacts (via PDZ domains) with GRIN2A (By similarity). Interacts (via PDZ domains) with KCND2 and KCND3 (PubMed:19213956). Interacts (via PDZ domains) with KCNA1, KCNA2, KCNA3 and KCNA4 (PubMed:7477295). Interacts (via PDZ domains) with ADGRA3 (PubMed:15021905). Interacts with KCNF1 (PubMed:12445884). Interacts with CAMK2 (By similarity). Interacts with cytoskeleton-associated protein EPB41 (PubMed:7937897, PubMed:8922391). Interacts with cytoskeleton-associated protein EZR (By similarity). Found in a complex with KCNA5 and CAV3 (By similarity). Found in a complex with APC and CTNNB1 (PubMed:10656683, PubMed:8638125). Interacts (via PDZ domains) with APC (PubMed:8638125). Interacts with CDH1 through binding to PIK3R1 (PubMed:14699157). Forms multiprotein complexes with CASK, LIN7A, LIN7B, LIN7C, APBA1, and KCNJ12 (By similarity). Interacts with TOPK (PubMed:10779557). Forms a tripartite complex composed of DLG1, MPP7 and LIN7 (LIN7A or LIN7C) (PubMed:17237226, PubMed:17332497, PubMed:20702775). May interact with TJAP1 (PubMed:11602598). Interacts with PTEN (By similarity). Interacts with FRMPD4 (via C-terminus) (PubMed:19118189). Interacts with LRFN1, LRFN2 and LRFN4 (PubMed:16630835). Interacts with SFPQ (PubMed:20605917). Interacts (via PDZ domains) with ADGRA2 (via PDZ-binding motif) (PubMed:15021905, PubMed:25558062). Interacts with ADAM10; this interaction recruits ADAM10 to the cell membrane during long-term depression in hippocampal neurons (PubMed:23676497). Interacts with DGKI (via PDZ-binding motif) (By similarity). Interacts (via PDZ domains) with MARCHF2 (via PDZ domain); the interaction leads to DLG1 ubiquitination and degradation (PubMed:17980554). Interacts (via N-terminus) with MPP3; this interaction connects CADM1 with DLG1 and links CADM1 with the regulatory subunit of phosphoinositide-3-kinase (PI3K) by forming a multiprotein complex and participates in cell spreading (PubMed:16519681, PubMed:24503895)"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10557085"}],"value":"(Microbial infection) Interacts with HTLV-1 protein Tax"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21849460"}],"value":"(Microbial infection) Interacts (via PDZ domains 1 and 2) with influenza A virus protein NS1; the interaction results in the translocation of DLG1 from the cell membrane to perinuclear puncta (PubMed:21849460). Acts as a scaffold protein to facilitate the interaction between LIN7C and influenza A virus protein NS1; the interaction facilitates translocation of LIN7C to cytoplasmic puncta (PubMed:21849460)"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9192623"}],"value":"(Microbial infection) Interacts with human papillomavirus 18/HPV-18 protein E6"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q12959","intActId":"EBI-357481"},"interactantTwo":{"uniProtKBAccession":"O95477","geneName":"ABCA1","intActId":"EBI-784112"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q12959","intActId":"EBI-357481"},"interactantTwo":{"uniProtKBAccession":"Q8IZY2","geneName":"ABCA7","intActId":"EBI-2838910"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q12959","intActId":"EBI-357481"},"interactantTwo":{"uniProtKBAccession":"O15439","geneName":"ABCC4","intActId":"EBI-4319622"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q12959","intActId":"EBI-357481"},"interactantTwo":{"uniProtKBAccession":"O95255","geneName":"ABCC6","intActId":"EBI-3925945"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q12959","intActId":"EBI-357481"},"interactantTwo":{"uniProtKBAccession":"Q9BYF1","geneName":"ACE2","intActId":"EBI-7730807"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q12959","intActId":"EBI-357481"},"interactantTwo":{"uniProtKBAccession":"Q3I5F7","geneName":"ACOT6","intActId":"EBI-21817245"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q12959","intActId":"EBI-357481"},"interactantTwo":{"uniProtKBAccession":"P35609","geneName":"ACTN2","intActId":"EBI-77797"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q12959","intActId":"EBI-357481"},"interactantTwo":{"uniProtKBAccession":"P27037","geneName":"ACVR2A","intActId":"EBI-296189"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q12959","intActId":"EBI-357481"},"interactantTwo":{"uniProtKBAccession":"P78536","geneName":"ADAM17","intActId":"EBI-78188"},"numberOfExperiments":9,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q12959","intActId":"EBI-357481"},"interactantTwo":{"uniProtKBAccession":"Q9P0K1","geneName":"ADAM22","intActId":"EBI-1567236"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q12959","intActId":"EBI-357481"},"interactantTwo":{"uniProtKBAccession":"Q86SQ6","geneName":"ADGRA1","intActId":"EBI-11794706"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q12959","intActId":"EBI-357481"},"interactantTwo":{"uniProtKBAccession":"Q96PE1","geneName":"ADGRA2","intActId":"EBI-10893263"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q12959","intActId":"EBI-357481"},"interactantTwo":{"uniProtKBAccession":"Q8IWK6","geneName":"ADGRA3","intActId":"EBI-10919800"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q12959","intActId":"EBI-357481"},"interactantTwo":{"uniProtKBAccession":"P48960","geneName":"ADGRE5","intActId":"EBI-1756009"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q12959","intActId":"EBI-357481"},"interactantTwo":{"uniProtKBAccession":"Q9Y653","geneName":"ADGRG1","intActId":"EBI-2833004"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q12959","intActId":"EBI-357481"},"interactantTwo":{"uniProtKBAccession":"P25100","geneName":"ADRA1D","intActId":"EBI-489993"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q12959","intActId":"EBI-357481"},"interactantTwo":{"uniProtKBAccession":"P08588","geneName":"ADRB1","intActId":"EBI-991009"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q12959","intActId":"EBI-357481"},"interactantTwo":{"uniProtKBAccession":"P07550","geneName":"ADRB2","intActId":"EBI-491169"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q12959","intActId":"EBI-357481"},"interactantTwo":{"uniProtKBAccession":"Q9BSE5","geneName":"AGMAT","intActId":"EBI-11910382"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q12959","intActId":"EBI-357481"},"interactantTwo":{"uniProtKBAccession":"O43572","geneName":"AKAP10","intActId":"EBI-752153"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q12959","intActId":"EBI-357481"},"interactantTwo":{"uniProtKBAccession":"Q9NQ31","geneName":"AKIP1","intActId":"EBI-517035"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q12959","intActId":"EBI-357481"},"interactantTwo":{"uniProtKBAccession":"Q8IY63","geneName":"AMOTL1","intActId":"EBI-1057112"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q12959","intActId":"EBI-357481"},"interactantTwo":{"uniProtKBAccession":"Q9NQ90","geneName":"ANO2","intActId":"EBI-20731422"},"numberOfExperiments":2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