{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q92813","secondaryAccessions":["B9EGK0","G3V315","Q6B0A3","Q9HCP7","Q9HCP8","Q9P1W4","Q9UDZ1"],"uniProtkbId":"IOD2_HUMAN","entryAudit":{"firstPublicDate":"1997-11-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2008-02-26","entryVersion":203,"sequenceVersion":4},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Type II iodothyronine deiodinase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10403186"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11108274"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12586771"}],"value":"1.21.99.4"}]},"alternativeNames":[{"fullName":{"value":"5DII"}},{"fullName":{"value":"DIOII"}},{"fullName":{"value":"Type 2 DI"}},{"fullName":{"value":"Type-II 5'-deiodinase"}}]},"genes":[{"geneName":{"value":"DIO2"},"synonyms":[{"value":"ITDI2"},{"value":"TXDI2"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10403186"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11108274"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12586771"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18339710"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18821722"}],"value":"Plays a crucial role in the metabolism of thyroid hormones (TH) and has specific roles in TH activation and inactivation by deiodination (PubMed:12586771, PubMed:11108274, PubMed:10403186, PubMed:18821722). 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