{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q92499","secondaryAccessions":["B4DME8","B4DPN6"],"uniProtkbId":"DDX1_HUMAN","entryAudit":{"firstPublicDate":"2000-05-30","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1998-08-01","entryVersion":223,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"21589879"}],"value":"ATP-dependent RNA helicase DDX1"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21589879"}],"value":"3.6.4.13"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:2734"}],"value":"DEAD box protein 1"}},{"fullName":{"value":"DEAD box protein retinoblastoma"},"shortNames":[{"value":"DBP-RB"}]}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:2734"}],"value":"DDX1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q91VR5"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12183465"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15567440"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18335541"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18710941"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20573827"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24870230"}],"value":"Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. 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Cooperates with ZBTB8OS (also known as archease) for the guanylylation of RTCB, a key intermediate step in activation of the tRNA ligase (PubMed:24870230). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1. Specifically binds (via helicase ATP-binding domain) on both short and long poly(I:C) dsRNA (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15567440"}],"value":"(Microbial infection) Required for HIV-1 Rev function as well as for HIV-1 and coronavirus IBV replication. 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