{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q6ZNG2","uniProtkbId":"DBX2_HUMAN","entryAudit":{"firstPublicDate":"2007-09-11","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2010-05-18","entryVersion":153,"sequenceVersion":2},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Homeobox protein DBX2"}},"alternativeNames":[{"fullName":{"value":"Developing brain homeobox protein 2"}}]},"genes":[{"geneName":{"value":"DBX2"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00108"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the H2.0 homeobox family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":339,"modifier":"EXACT"}},"description":"Homeobox protein DBX2","featureId":"PRO_0000302849"},{"type":"DNA binding","location":{"start":{"value":186,"modifier":"EXACT"},"end":{"value":245,"modifier":"EXACT"}},"description":"Homeobox","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00108"}]},{"type":"Region","location":{"start":{"value":282,"modifier":"EXACT"},"end":{"value":318,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":290,"modifier":"EXACT"},"end":{"value":303,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Natural variant","location":{"start":{"value":171,"modifier":"EXACT"},"end":{"value":171,"modifier":"EXACT"}},"description":"in dbSNP:rs2731038","featureCrossReferences":[{"database":"dbSNP","id":"rs2731038"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14702039"}],"featureId":"VAR_034969","alternativeSequence":{"originalSequence":"M","alternativeSequences":["V"]}}],"keywords":[{"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"id":"KW-0371","category":"Domain","name":"Homeobox"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]","VARIANT VAL-171"]},{"referenceNumber":2,"citation":{"id":"16541075","citationType":"journal article","authors":["Scherer S.E.","Muzny D.M.","Buhay C.J.","Chen R.","Cree A.","Ding Y.","Dugan-Rocha S.","Gill R.","Gunaratne P.","Harris R.A.","Hawes A.C.","Hernandez J.","Hodgson A.V.","Hume J.","Jackson A.","Khan Z.M.","Kovar-Smith C.","Lewis L.R.","Lozado R.J.","Metzker M.L.","Milosavljevic A.","Miner G.R.","Montgomery K.T.","Morgan M.B.","Nazareth L.V.","Scott G.","Sodergren E.","Song X.-Z.","Steffen D.","Lovering R.C.","Wheeler D.A.","Worley K.C.","Yuan Y.","Zhang Z.","Adams C.Q.","Ansari-Lari M.A.","Ayele M.","Brown M.J.","Chen G.","Chen Z.","Clerc-Blankenburg K.P.","Davis C.","Delgado O.","Dinh H.H.","Draper H.","Gonzalez-Garay M.L.","Havlak P.","Jackson L.R.","Jacob L.S.","Kelly S.H.","Li L.","Li Z.","Liu J.","Liu W.","Lu J.","Maheshwari M.","Nguyen B.-V.","Okwuonu G.O.","Pasternak S.","Perez L.M.","Plopper F.J.H.","Santibanez J.","Shen H.","Tabor P.E.","Verduzco D.","Waldron L.","Wang Q.","Williams G.A.","Zhang J.","Zhou J.","Allen C.C.","Amin A.G.","Anyalebechi V.","Bailey M.","Barbaria J.A.","Bimage K.E.","Bryant N.P.","Burch P.E.","Burkett C.E.","Burrell K.L.","Calderon E.","Cardenas V.","Carter K.","Casias K.","Cavazos I.","Cavazos S.R.","Ceasar H.","Chacko J.","Chan S.N.","Chavez D.","Christopoulos C.","Chu J.","Cockrell R.","Cox C.D.","Dang M.","Dathorne S.R.","David R.","Davis C.M.","Davy-Carroll L.","Deshazo D.R.","Donlin J.E.","D'Souza L.","Eaves K.A.","Egan A.","Emery-Cohen A.J.","Escotto M.","Flagg N.","Forbes L.D.","Gabisi A.M.","Garza M.","Hamilton C.","Henderson N.","Hernandez O.","Hines S.","Hogues M.E.","Huang M.","Idlebird D.G.","Johnson R.","Jolivet A.","Jones S.","Kagan R.","King L.M.","Leal B.","Lebow H.","Lee S.","LeVan J.M.","Lewis L.C.","London P.","Lorensuhewa L.M.","Loulseged H.","Lovett D.A.","Lucier A.","Lucier R.L.","Ma J.","Madu R.C.","Mapua P.","Martindale A.D.","Martinez E.","Massey E.","Mawhiney S.","Meador M.G.","Mendez S.","Mercado C.","Mercado I.C.","Merritt C.E.","Miner Z.L.","Minja E.","Mitchell T.","Mohabbat F.","Mohabbat K.","Montgomery B.","Moore N.","Morris S.","Munidasa M.","Ngo R.N.","Nguyen N.B.","Nickerson E.","Nwaokelemeh O.O.","Nwokenkwo S.","Obregon M.","Oguh M.","Oragunye N.","Oviedo R.J.","Parish B.J.","Parker D.N.","Parrish J.","Parks K.L.","Paul H.A.","Payton B.A.","Perez A.","Perrin W.","Pickens A.","Primus E.L.","Pu L.-L.","Puazo M.","Quiles M.M.","Quiroz J.B.","Rabata D.","Reeves K.","Ruiz S.J.","Shao H.","Sisson I.","Sonaike T.","Sorelle R.P.","Sutton A.E.","Svatek A.F.","Svetz L.A.","Tamerisa K.S.","Taylor T.R.","Teague B.","Thomas N.","Thorn R.D.","Trejos Z.Y.","Trevino B.K.","Ukegbu O.N.","Urban J.B.","Vasquez L.I.","Vera V.A.","Villasana D.M.","Wang L.","Ward-Moore S.","Warren J.T.","Wei X.","White F.","Williamson A.L.","Wleczyk R.","Wooden H.S.","Wooden S.H.","Yen J.","Yoon L.","Yoon V.","Zorrilla S.E.","Nelson D.","Kucherlapati R.","Weinstock G.","Gibbs R.A."],"citationCrossReferences":[{"database":"PubMed","id":"16541075"},{"database":"DOI","id":"10.1038/nature04569"}],"title":"The finished DNA sequence of human chromosome 12.","publicationDate":"2006","journal":"Nature","firstPage":"346","lastPage":"351","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AK131230","properties":[{"key":"ProteinId","value":"BAD18413.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AC008127","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC079033","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC089986","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"CCDS","id":"CCDS31781.1","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_001004329.2","properties":[{"key":"NucleotideSequenceId","value":"NM_001004329.3"}]},{"database":"AlphaFoldDB","id":"Q6ZNG2","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q6ZNG2","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"136293","properties":[{"key":"Interactions","value":"11"}]},{"database":"FunCoup","id":"Q6ZNG2","properties":[{"key":"Number of interactors","value":"338"}]},{"database":"IntAct","id":"Q6ZNG2","properties":[{"key":"Interactions","value":"5"}]},{"database":"STRING","id":"9606.ENSP00000331470","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"Q6ZNG2","properties":[{"key":"glycosylation","value":"1 site"}]},{"database":"iPTMnet","id":"Q6ZNG2","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q6ZNG2","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"DBX2","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"296434473","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q6ZNG2","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000331470","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q6ZNG2","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"25226","properties":[{"key":"antibodies","value":"144 antibodies from 24 providers"}]},{"database":"DNASU","id":"440097","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000332700.6","properties":[{"key":"ProteinId","value":"ENSP00000331470.6"},{"key":"GeneId","value":"ENSG00000185610.6"}]},{"database":"GeneID","id":"440097","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:440097","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000332700.6","properties":[{"key":"ProteinId","value":"ENSP00000331470.6"},{"key":"RefSeqNucleotideId","value":"NM_001004329.3"},{"key":"RefSeqProteinId","value":"NP_001004329.2"}]},{"database":"UCSC","id":"uc001rok.2","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:33186","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA162383249","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"440097","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"440097","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"DBX2","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:33186","properties":[{"key":"GeneName","value":"DBX2"}]},{"database":"HPA","id":"ENSG00000185610","properties":[{"key":"ExpressionPatterns","value":"Tissue enriched (brain)"}]},{"database":"MalaCards","id":"DBX2","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"620706","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000185610","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000185610","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG0488","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00950000183093","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_053401_2_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q6ZNG2","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"FPARWAF","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"6159439at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q6ZNG2","properties":[{"key":"Number of GO annotations","value":"1 GO annotation based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q6ZNG2","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q6ZNG2","properties":[{"key":"Description","value":"-"}]},{"database":"SignaLink","id":"Q6ZNG2","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000185610","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"440097","properties":[{"key":"hits","value":"9 hits in 1172 CRISPR screens"}]},{"database":"GeneWiki","id":"DBX2","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"440097","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q6ZNG2","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:Q6ZNG2","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 12"}]},{"database":"RNAct","id":"Q6ZNG2","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000185610","properties":[{"key":"ExpressionPatterns","value":"Expressed in male germ line stem cell (sensu Vertebrata) in testis and 42 other cell types or tissues"}]},{"database":"GO","id":"GO:0000785","properties":[{"key":"GoTerm","value":"C:chromatin"},{"key":"GoEvidenceType","value":"ISA:NTNU_SB"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0003677","properties":[{"key":"GoTerm","value":"F:DNA binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0000981","properties":[{"key":"GoTerm","value":"F:DNA-binding transcription factor activity, RNA polymerase II-specific"},{"key":"GoEvidenceType","value":"ISA:NTNU_SB"}]},{"database":"GO","id":"GO:0006357","properties":[{"key":"GoTerm","value":"P:regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"CDD","id":"cd00086","properties":[{"key":"EntryName","value":"homeodomain"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.10.60:FF:000187","properties":[{"key":"EntryName","value":"homeobox protein DBX2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.10.60","properties":[{"key":"EntryName","value":"Homeodomain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR051662","properties":[{"key":"EntryName","value":"H2.0_Homeobox_NeuralPatt"}]},{"database":"InterPro","id":"IPR001356","properties":[{"key":"EntryName","value":"HD"}]},{"database":"InterPro","id":"IPR020479","properties":[{"key":"EntryName","value":"HD_metazoa"}]},{"database":"InterPro","id":"IPR017970","properties":[{"key":"EntryName","value":"Homeobox_CS"}]},{"database":"InterPro","id":"IPR009057","properties":[{"key":"EntryName","value":"Homeodomain-like_sf"}]},{"database":"InterPro","id":"IPR000047","properties":[{"key":"EntryName","value":"HTH_motif"}]},{"database":"PANTHER","id":"PTHR24331","properties":[{"key":"EntryName","value":"DBX"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR24331:SF4","properties":[{"key":"EntryName","value":"HOMEOBOX PROTEIN DBX2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00046","properties":[{"key":"EntryName","value":"Homeodomain"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00024","properties":[{"key":"EntryName","value":"HOMEOBOX"}]},{"database":"PRINTS","id":"PR00031","properties":[{"key":"EntryName","value":"HTHREPRESSR"}]},{"database":"SMART","id":"SM00389","properties":[{"key":"EntryName","value":"HOX"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF46689","properties":[{"key":"EntryName","value":"Homeodomain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00027","properties":[{"key":"EntryName","value":"HOMEOBOX_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50071","properties":[{"key":"EntryName","value":"HOMEOBOX_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MLPSAVAAHAGAYWDVVASSALLNLPAAPGFGNLGKSFLIENLLRVGGAPTPRLQPPAPHDPATALATAGAQLRPLPASPVPLKLCPAAEQVSPAGAPYGTRWAFQVLSPSADSARLPGRAPGDRDCTFQPSAPAPSKPFLLSTPPFYSACCGGSCRRPASSTAFPREESMLPLLTQDSNSKARRGILRRAVFSEDQRKALEKMFQKQKYISKTDRKKLAINLGLKESQVKIWFQNRRMKWRNSKEKEVLSNRCIQEVGLQEDPLSRSALGFPSPCPSIWDVPQQHSSPRWRENSPEPSERLIQESSGAPPPEANSLQGALYLCSEEEAGSKGVLTGAV","length":339,"molWeight":36555,"crc64":"7E9CAD61C3DAEBEB","md5":"5009A22AEBB5373F6DC040356D8DE11F"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"DNA binding":1,"Region":1,"Compositional bias":1,"Natural variant":1},"uniParcId":"UPI000041A784"}}]}