{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q10586","secondaryAccessions":["A2I2P4"],"uniProtkbId":"DBP_HUMAN","entryAudit":{"firstPublicDate":"1996-10-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1996-10-01","entryVersion":192,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"D site-binding protein"}},"alternativeNames":[{"fullName":{"value":"Albumin D box-binding protein"}},{"fullName":{"value":"Albumin D-element-binding protein"}},{"fullName":{"value":"Tax-responsive enhancer element-binding protein 302"},"shortNames":[{"value":"TaxREB302"}]}]},"genes":[{"geneName":{"value":"DBP"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10073576"}],"value":"This transcriptional activator recognizes and binds to the sequence 5'-RTTAYGTAAY-3' found in the promoter of genes such as albumin, CYP2A4 and CYP2A5. It is not essential for circadian rhythm generation, but modulates important clock output genes. May be a direct target for regulation by the circadian pacemaker component clock. May affect circadian period and sleep regulation. Activates transcription of coagulation factors F8 and F9; transactivation activity is enhanced by formation of a heterodimer with HLF (PubMed:10073576)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10073576"}],"value":"Binds DNA as a homodimer or a heterodimer. Can form a heterodimer with TEF. Forms heterodimers with PAR protein HLF; this enhances transactivation activity towards coagulation factors F8 and F9 (PubMed:10073576)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q10586","intActId":"EBI-3908088"},"interactantTwo":{"uniProtKBAccession":"Q16520","geneName":"BATF","intActId":"EBI-749503"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q10586","intActId":"EBI-3908088"},"interactantTwo":{"uniProtKBAccession":"Q9NR55","geneName":"BATF3","intActId":"EBI-10312707"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q10586","intActId":"EBI-3908088"},"interactantTwo":{"uniProtKBAccession":"P35638","geneName":"DDIT3","intActId":"EBI-742651"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q10586","intActId":"EBI-3908088"},"interactantTwo":{"uniProtKBAccession":"Q16534","geneName":"HLF","intActId":"EBI-2798854"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"value":"Ubiquitously expressed. Expressed in the suprachiasmatic nuclei (SCN) and in most peripheral tissues, with a strong circadian rhythmicity"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the bZIP family. PAR subfamily"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":325,"modifier":"EXACT"}},"description":"D site-binding protein","featureId":"PRO_0000076507"},{"type":"Domain","location":{"start":{"value":255,"modifier":"EXACT"},"end":{"value":318,"modifier":"EXACT"}},"description":"bZIP","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00978"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":99,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":127,"modifier":"EXACT"},"end":{"value":200,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":229,"modifier":"EXACT"},"end":{"value":255,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":257,"modifier":"EXACT"},"end":{"value":279,"modifier":"EXACT"}},"description":"Basic motif","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00978"}]},{"type":"Region","location":{"start":{"value":283,"modifier":"EXACT"},"end":{"value":297,"modifier":"EXACT"}},"description":"Leucine-zipper","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00978"}]},{"type":"Compositional bias","location":{"start":{"value":17,"modifier":"EXACT"},"end":{"value":28,"modifier":"EXACT"}},"description":"Gly residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":29,"modifier":"EXACT"},"end":{"value":38,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":57,"modifier":"EXACT"},"end":{"value":80,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":129,"modifier":"EXACT"},"end":{"value":153,"modifier":"EXACT"}},"description":"Pro residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":157,"modifier":"EXACT"},"end":{"value":167,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":86,"modifier":"EXACT"},"end":{"value":86,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Sequence conflict","location":{"start":{"value":179,"modifier":"EXACT"},"end":{"value":179,"modifier":"EXACT"}},"description":"in Ref. 1; AAA81374","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["T"]}},{"type":"Sequence conflict","location":{"start":{"value":245,"modifier":"EXACT"},"end":{"value":245,"modifier":"EXACT"}},"description":"in Ref. 8; BAA05833","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["K"]}}],"keywords":[{"id":"KW-0010","category":"Molecular function","name":"Activator"},{"id":"KW-0090","category":"Biological process","name":"Biological rhythms"},{"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0804","category":"Biological process","name":"Transcription"},{"id":"KW-0805","category":"Biological process","name":"Transcription regulation"}],"references":[{"referenceNumber":1,"citation":{"id":"7835883","citationType":"journal article","authors":["Khatib Z.A.","Inaba T.","Valentine M.","Look A.T."],"citationCrossReferences":[{"database":"PubMed","id":"7835883"},{"database":"DOI","id":"10.1006/geno.1994.1510"}],"title":"Chromosomal localization and cDNA cloning of the human DBP and TEF genes.","publicationDate":"1994","journal":"Genomics","firstPage":"344","lastPage":"351","volume":"23"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"]},{"referenceNumber":2,"citation":{"id":"8786133","citationType":"journal article","authors":["Shutler G.","Glassco T.","Kang X.","Korneluk R.","Mueller C.R."],"citationCrossReferences":[{"database":"PubMed","id":"8786133"},{"database":"DOI","id":"10.1006/geno.1996.0295"}],"title":"Genomic structure of the human D-site binding protein (DBP) gene.","publicationDate":"1996","journal":"Genomics","firstPage":"334","lastPage":"339","volume":"34"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":3,"citation":{"id":"CI-7NVK8Q9658Q3","citationType":"submission","authoringGroup":["NHLBI resequencing and genotyping service (RS&G)"],"publicationDate":"SEP-2006","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":4,"citation":{"id":"9110174","citationType":"journal article","authors":["Yu W.","Andersson B.","Worley K.C.","Muzny D.M.","Ding Y.","Liu W.","Ricafrente J.Y.","Wentland M.A.","Lennon G.","Gibbs R.A."],"citationCrossReferences":[{"database":"PubMed","id":"9110174"},{"database":"DOI","id":"10.1101/gr.7.4.353"}],"title":"Large-scale concatenation cDNA sequencing.","publicationDate":"1997","journal":"Genome Res.","firstPage":"353","lastPage":"358","volume":"7"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"CI-4IUTJLP3044AK","citationType":"submission","authors":["Kalnine N.","Chen X.","Rolfs A.","Halleck A.","Hines L.","Eisenstein S.","Koundinya M.","Raphael J.","Moreira D.","Kelley T.","LaBaer J.","Lin Y.","Phelan M.","Farmer A."],"title":"Cloning of human full-length CDSs in BD Creator(TM) system donor vector.","publicationDate":"MAY-2003","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"]},{"referenceNumber":6,"citation":{"id":"CI-5GBDQ6B103N1E","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"JUL-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":7,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Ovary","type":"TISSUE"}]},{"referenceNumber":8,"citation":{"id":"8482542","citationType":"journal article","authors":["Nyunoya H.","Morita T.","Sato T.","Honma S.","Tsujimoto A.","Shimotohno K."],"citationCrossReferences":[{"database":"PubMed","id":"8482542"},{"database":"DOI","id":"10.1016/0378-1119(93)90375-d"}],"title":"Cloning of a cDNA encoding a DNA-binding protein TAXREB302 that is specific for the tax-responsive enhancer of HTLV-I.","publicationDate":"1993","journal":"Gene","firstPage":"251","lastPage":"255","volume":"126"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF 132-325"]},{"referenceNumber":9,"citation":{"id":"CI-822GPN60KEEQD","citationType":"submission","authors":["Nyunoya H."],"publicationDate":"MAR-1994","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["SEQUENCE REVISION"]},{"referenceNumber":10,"citation":{"id":"10508692","citationType":"journal article","authors":["Brown S.A.","Schibler U."],"citationCrossReferences":[{"database":"PubMed","id":"10508692"},{"database":"DOI","id":"10.1016/s0959-437x(99)00009-x"}],"title":"The ins and outs of circadian timekeeping.","publicationDate":"1999","journal":"Curr. Opin. Genet. Dev.","firstPage":"588","lastPage":"594","volume":"9"},"referencePositions":["REVIEW"]},{"referenceNumber":11,"citation":{"id":"10073576","citationType":"journal article","authors":["Begbie M.","Mueller C.","Lillicrap D."],"citationCrossReferences":[{"database":"PubMed","id":"10073576"},{"database":"DOI","id":"10.1089/104454999315556"}],"title":"Enhanced binding of HLF/DBP heterodimers represents one mechanism of PAR protein transactivation of the factor VIII and factor IX genes.","publicationDate":"1999","journal":"DNA Cell Biol.","firstPage":"165","lastPage":"173","volume":"18"},"referencePositions":["FUNCTION","SUBUNIT"]},{"referenceNumber":12,"citation":{"id":"20068231","citationType":"journal article","authors":["Olsen J.V.","Vermeulen M.","Santamaria A.","Kumar C.","Miller M.L.","Jensen L.J.","Gnad F.","Cox J.","Jensen T.S.","Nigg E.A.","Brunak S.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"20068231"},{"database":"DOI","id":"10.1126/scisignal.2000475"}],"title":"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.","publicationDate":"2010","journal":"Sci. Signal.","firstPage":"RA3","lastPage":"RA3","volume":"3"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-86","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":13,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-86","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"U06936","properties":[{"key":"ProteinId","value":"AAA81374.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"U48213","properties":[{"key":"ProteinId","value":"AAB18668.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"U48212","properties":[{"key":"ProteinId","value":"AAB18668.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"EF015902","properties":[{"key":"ProteinId","value":"ABM64213.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"U79283","properties":[{"key":"ProteinId","value":"AAB50219.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BT006836","properties":[{"key":"ProteinId","value":"AAP35482.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"CH471177","properties":[{"key":"ProteinId","value":"EAW52374.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC011965","properties":[{"key":"ProteinId","value":"AAH11965.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"D28468","properties":[{"key":"ProteinId","value":"BAA05833.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS12728.1","properties":[{"key":"Description","value":"-"}]},{"database":"PIR","id":"A55558","properties":[{"key":"EntryName","value":"A55558"}]},{"database":"RefSeq","id":"NP_001343.2","properties":[{"key":"NucleotideSequenceId","value":"NM_001352.5"}]},{"database":"AlphaFoldDB","id":"Q10586","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q10586","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"107996","properties":[{"key":"Interactions","value":"13"}]},{"database":"ComplexPortal","id":"CPX-7014","properties":[{"key":"EntryName","value":"bZIP transcription factor complex, BATF-DBP"}]},{"database":"ComplexPortal","id":"CPX-7068","properties":[{"key":"EntryName","value":"bZIP transcription factor complex, BATF2-DBP"}]},{"database":"ComplexPortal","id":"CPX-7108","properties":[{"key":"EntryName","value":"bZIP transcription factor complex, BATF3-DBP"}]},{"database":"FunCoup","id":"Q10586","properties":[{"key":"Number of interactors","value":"260"}]},{"database":"IntAct","id":"Q10586","properties":[{"key":"Interactions","value":"9"}]},{"database":"NDEx","id":"IQUERY-CP-DBP","properties":[{"key":"Evidences","value":"4 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000222122","properties":[{"key":"Description","value":"-"}]},{"database":"iPTMnet","id":"Q10586","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q10586","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"DBP","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"1706312","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q10586","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q10586","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000222122","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q10586","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"58862","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"18372","properties":[{"key":"antibodies","value":"126 antibodies from 24 providers"}]},{"database":"DNASU","id":"1628","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000222122.10","properties":[{"key":"ProteinId","value":"ENSP00000222122.4"},{"key":"GeneId","value":"ENSG00000105516.11"}]},{"database":"GeneID","id":"1628","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:1628","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000222122.10","properties":[{"key":"ProteinId","value":"ENSP00000222122.4"},{"key":"RefSeqNucleotideId","value":"NM_001352.5"},{"key":"RefSeqProteinId","value":"NP_001343.2"}]},{"database":"UCSC","id":"uc002pjx.5","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:2697","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA27165","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"1628","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"1628","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"DBP","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:2697","properties":[{"key":"GeneName","value":"DBP"}]},{"database":"HPA","id":"ENSG00000105516","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MIM","id":"124097","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000105516","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000105516","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG3119","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000162136","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_051922_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q10586","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"EYEHPSS","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"6022300at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q10586","properties":[{"key":"Number of GO annotations","value":"4 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q10586","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q10586","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-9931510","properties":[{"key":"PathwayName","value":"Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes"}]},{"database":"SignaLink","id":"Q10586","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"Q10586","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000105516","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"1628","properties":[{"key":"hits","value":"19 hits in 1189 CRISPR screens"}]},{"database":"ChiTaRS","id":"DBP","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GeneWiki","id":"DBP_(gene)","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"1628","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q10586","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:Q10586","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 19"}]},{"database":"RNAct","id":"Q10586","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000105516","properties":[{"key":"ExpressionPatterns","value":"Expressed in right hemisphere of cerebellum and 179 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q10586","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0000785","properties":[{"key":"GoTerm","value":"C:chromatin"},{"key":"GoEvidenceType","value":"ISA:NTNU_SB"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0090575","properties":[{"key":"GoTerm","value":"C:RNA polymerase II transcription regulator complex"},{"key":"GoEvidenceType","value":"IPI:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"23661758"}]},{"database":"GO","id":"GO:0001228","properties":[{"key":"GoTerm","value":"F:DNA-binding transcription activator activity, RNA polymerase II-specific"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10073576"}]},{"database":"GO","id":"GO:0000981","properties":[{"key":"GoTerm","value":"F:DNA-binding transcription factor activity, RNA polymerase II-specific"},{"key":"GoEvidenceType","value":"ISA:NTNU_SB"}]},{"database":"GO","id":"GO:0046982","properties":[{"key":"GoTerm","value":"F:protein heterodimerization activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10073576"}]},{"database":"GO","id":"GO:0000978","properties":[{"key":"GoTerm","value":"F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0000977","properties":[{"key":"GoTerm","value":"F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20093779"}]},{"database":"GO","id":"GO:1990837","properties":[{"key":"GoTerm","value":"F:sequence-specific double-stranded DNA binding"},{"key":"GoEvidenceType","value":"IDA:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"28473536"}]},{"database":"GO","id":"GO:0001889","properties":[{"key":"GoTerm","value":"P:liver development"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0045944","properties":[{"key":"GoTerm","value":"P:positive regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10073576"}]},{"database":"GO","id":"GO:0006357","properties":[{"key":"GoTerm","value":"P:regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"8786133"}]},{"database":"CDD","id":"cd14695","properties":[{"key":"EntryName","value":"bZIP_HLF"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.5.170:FF:000007","properties":[{"key":"EntryName","value":"hepatic leukemia factor isoform X2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.5.170","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR004827","properties":[{"key":"EntryName","value":"bZIP"}]},{"database":"InterPro","id":"IPR046347","properties":[{"key":"EntryName","value":"bZIP_sf"}]},{"database":"InterPro","id":"IPR040223","properties":[{"key":"EntryName","value":"PAR_bZIP"}]},{"database":"PANTHER","id":"PTHR11988:SF7","properties":[{"key":"EntryName","value":"D SITE-BINDING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11988","properties":[{"key":"EntryName","value":"THYROTROPH EMBRYONIC FACTOR RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07716","properties":[{"key":"EntryName","value":"bZIP_2"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00338","properties":[{"key":"EntryName","value":"BRLZ"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57959","properties":[{"key":"EntryName","value":"Leucine zipper domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50217","properties":[{"key":"EntryName","value":"BZIP"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MARPVSDRTPAPLLLGGPAGTPPGGGALLGLRSLLQGTSKPKEPASCLLKEKERKAALPAATTPGPGLETAGPADAPAGAVVGGGSPRGRPGPVPAPGLLAPLLWERTLPFGDVEYVDLDAFLLEHGLPPSPPPPGGPSPEPSPARTPAPSPGPGSCGSASPRSSPGHAPARAALGTASGHRAGLTSRDTPSPVDPDTVEVLMTFEPDPADLALSSIPGHETFDPRRHRFSEEELKPQPIMKKARKIQVPEEQKDEKYWSRRYKNNEAAKRSRDARRLKENQISVRAAFLEKENALLRQEVVAVRQELSHYRAVLSRYQAQHGAL","length":325,"molWeight":34349,"crc64":"A6933CE21399ECF3","md5":"F32DF146B0DFD7B6795C2EA040EE41E7"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"INTERACTION":4,"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Domain":1,"Region":5,"Compositional bias":5,"Modified residue":1,"Sequence conflict":2},"uniParcId":"UPI0000000CC1"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"M0QXP1","uniProtkbId":"M0QXP1_HUMAN","entryAudit":{"firstPublicDate":"2013-04-03","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2013-04-03","entryVersion":72,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000469291.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000469291.1"}],"value":"D-box binding PAR bZIP transcription factor"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000469291.1"}],"value":"DBP"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004123"}],"value":"Nucleus","id":"SL-0191"}}]}],"features":[{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":99,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":127,"modifier":"EXACT"},"end":{"value":262,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":17,"modifier":"EXACT"},"end":{"value":28,"modifier":"EXACT"}},"description":"Gly residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":29,"modifier":"EXACT"},"end":{"value":38,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":57,"modifier":"EXACT"},"end":{"value":80,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":129,"modifier":"EXACT"},"end":{"value":153,"modifier":"EXACT"}},"description":"Pro residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":157,"modifier":"EXACT"},"end":{"value":167,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":221,"modifier":"EXACT"},"end":{"value":236,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023125"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"M0QXP1"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"M0QXP1"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023163"}],"id":"KW-0804","category":"Biological process","name":"Transcription"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023015"}],"id":"KW-0805","category":"Biological process","name":"Transcription regulation"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000469291.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15057824","citationType":"journal article","authors":["Grimwood J.","Gordon L.A.","Olsen A.","Terry A.","Schmutz J.","Lamerdin J.","Hellsten U.","Goodstein D.","Couronne O.","Tran-Gyamfi M.","Aerts A.","Altherr M.","Ashworth L.","Bajorek E.","Black S.","Branscomb E.","Caenepeel S.","Carrano A.","Caoile C.","Chan Y.M.","Christensen M.","Cleland C.A.","Copeland A.","Dalin E.","Dehal P.","Denys M.","Detter J.C.","Escobar J.","Flowers D.","Fotopulos D.","Garcia C.","Georgescu A.M.","Glavina T.","Gomez M.","Gonzales E.","Groza M.","Hammon N.","Hawkins T.","Haydu L.","Ho I.","Huang W.","Israni S.","Jett J.","Kadner K.","Kimball H.","Kobayashi A.","Larionov V.","Leem S.H.","Lopez F.","Lou Y.","Lowry S.","Malfatti S.","Martinez D.","McCready P.","Medina C.","Morgan J.","Nelson K.","Nolan M.","Ovcharenko I.","Pitluck S.","Pollard M.","Popkie A.P.","Predki P.","Quan G.","Ramirez L.","Rash S.","Retterer J.","Rodriguez A.","Rogers S.","Salamov A.","Salazar A.","She X.","Smith D.","Slezak T.","Solovyev V.","Thayer N.","Tice H.","Tsai M.","Ustaszewska A.","Vo N.","Wagner M.","Wheeler J.","Wu K.","Xie G.","Yang J.","Dubchak I.","Furey T.S.","DeJong P.","Dickson M.","Gordon D.","Eichler E.E.","Pennacchio L.A.","Richardson P.","Stubbs L.","Rokhsar D.S.","Myers R.M.","Rubin E.M.","Lucas S.M."],"citationCrossReferences":[{"database":"PubMed","id":"15057824"},{"database":"DOI","id":"10.1038/nature02399"}],"title":"The DNA sequence and biology of human chromosome 19.","publicationDate":"2004","journal":"Nature","firstPage":"529","lastPage":"535","volume":"428"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000469291.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000469291.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"20068231","citationType":"journal article","authors":["Olsen J.V.","Vermeulen M.","Santamaria A.","Kumar C.","Miller M.L.","Jensen L.J.","Gnad F.","Cox J.","Jensen T.S.","Nigg E.A.","Brunak S.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"20068231"},{"database":"DOI","id":"10.1126/scisignal.2000475"}],"title":"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.","publicationDate":"2010","journal":"Sci. Signal.","firstPage":"RA3","lastPage":"RA3","volume":"3"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"20068231"}]},{"referenceNumber":5,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"24275569"}]},{"referenceNumber":6,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000469291.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC008888","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC022154","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"M0QXP1","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"M0QXP1","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"18372","properties":[{"key":"antibodies","value":"126 antibodies from 24 providers"}]},{"database":"Ensembl","id":"ENST00000601104.1","properties":[{"key":"ProteinId","value":"ENSP00000469291.1"},{"key":"GeneId","value":"ENSG00000105516.11"}]},{"database":"UCSC","id":"uc010elz.2","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:2697","properties":[{"key":"GeneName","value":"DBP"}]},{"database":"OpenTargets","id":"ENSG00000105516","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000105516","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000162136","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"6022300at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"DBP","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 19"}]},{"database":"Bgee","id":"ENSG00000105516","properties":[{"key":"ExpressionPatterns","value":"Expressed in right hemisphere of cerebellum and 179 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"M0QXP1","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0003700","properties":[{"key":"GoTerm","value":"F:DNA-binding transcription factor activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006357","properties":[{"key":"GoTerm","value":"P:regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"InterPro","id":"IPR040223","properties":[{"key":"EntryName","value":"PAR_bZIP"}]},{"database":"PANTHER","id":"PTHR11988:SF7","properties":[{"key":"EntryName","value":"D SITE-BINDING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11988","properties":[{"key":"EntryName","value":"THYROTROPH EMBRYONIC FACTOR RELATED"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MARPVSDRTPAPLLLGGPAGTPPGGGALLGLRSLLQGTSKPKEPASCLLKEKERKAALPAATTPGPGLETAGPADAPAGAVVGGGSPRGRPGPVPAPGLLAPLLWERTLPFGDVEYVDLDAFLLEHGLPPSPPPPGGPSPEPSPARTPAPSPGPGSCGSASPRSSPGHAPARAALGTASGHRAGLTSRDTPSPVDPDTVEVLMTFEPDPADLALSSIPGHETFDPRRHRFSEEELKPQPIMKKARKIQVPEEQKVSRAGCGR","length":262,"molWeight":26681,"crc64":"1EBF6FDFE90BA261","md5":"84537A78301D609A29C765812830F89F"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Region":2,"Compositional bias":6},"uniParcId":"UPI0002A473C4"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"M0QXW3","uniProtkbId":"M0QXW3_HUMAN","entryAudit":{"firstPublicDate":"2013-04-03","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2013-04-03","entryVersion":81,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000469426.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000469426.1"}],"value":"D-box binding PAR bZIP transcription factor"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000469426.1"}],"value":"DBP"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004123"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00978"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009208"}],"value":"Belongs to the bZIP family. PAR subfamily"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":53,"modifier":"EXACT"},"end":{"value":116,"modifier":"EXACT"}},"description":"BZIP","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50217"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":23,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023108"}],"id":"KW-0090","category":"Biological process","name":"Biological rhythms"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023125"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00978"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00978"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"M0QXW3"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"M0QXW3"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023163"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00978"}],"id":"KW-0804","category":"Biological process","name":"Transcription"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023015"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00978"}],"id":"KW-0805","category":"Biological process","name":"Transcription regulation"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000469426.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15057824","citationType":"journal article","authors":["Grimwood J.","Gordon L.A.","Olsen A.","Terry A.","Schmutz J.","Lamerdin J.","Hellsten U.","Goodstein D.","Couronne O.","Tran-Gyamfi M.","Aerts A.","Altherr M.","Ashworth L.","Bajorek E.","Black S.","Branscomb E.","Caenepeel S.","Carrano A.","Caoile C.","Chan Y.M.","Christensen M.","Cleland C.A.","Copeland A.","Dalin E.","Dehal P.","Denys M.","Detter J.C.","Escobar J.","Flowers D.","Fotopulos D.","Garcia C.","Georgescu A.M.","Glavina T.","Gomez M.","Gonzales E.","Groza M.","Hammon N.","Hawkins T.","Haydu L.","Ho I.","Huang W.","Israni S.","Jett J.","Kadner K.","Kimball H.","Kobayashi A.","Larionov V.","Leem S.H.","Lopez F.","Lou Y.","Lowry S.","Malfatti S.","Martinez D.","McCready P.","Medina C.","Morgan J.","Nelson K.","Nolan M.","Ovcharenko I.","Pitluck S.","Pollard M.","Popkie A.P.","Predki P.","Quan G.","Ramirez L.","Rash S.","Retterer J.","Rodriguez A.","Rogers S.","Salamov A.","Salazar A.","She X.","Smith D.","Slezak T.","Solovyev V.","Thayer N.","Tice H.","Tsai M.","Ustaszewska A.","Vo N.","Wagner M.","Wheeler J.","Wu K.","Xie G.","Yang J.","Dubchak I.","Furey T.S.","DeJong P.","Dickson M.","Gordon D.","Eichler E.E.","Pennacchio L.A.","Richardson P.","Stubbs L.","Rokhsar D.S.","Myers R.M.","Rubin E.M.","Lucas S.M."],"citationCrossReferences":[{"database":"PubMed","id":"15057824"},{"database":"DOI","id":"10.1038/nature02399"}],"title":"The DNA sequence and biology of human chromosome 19.","publicationDate":"2004","journal":"Nature","firstPage":"529","lastPage":"535","volume":"428"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000469426.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000469426.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000469426.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC008888","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC022154","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"M0QXW3","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"M0QXW3","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"18372","properties":[{"key":"antibodies","value":"126 antibodies from 24 providers"}]},{"database":"Ensembl","id":"ENST00000593500.1","properties":[{"key":"ProteinId","value":"ENSP00000471220.1"},{"key":"GeneId","value":"ENSG00000105516.11"}]},{"database":"Ensembl","id":"ENST00000599385.5","properties":[{"key":"ProteinId","value":"ENSP00000469426.1"},{"key":"GeneId","value":"ENSG00000105516.11"}]},{"database":"UCSC","id":"uc061ave.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:2697","properties":[{"key":"GeneName","value":"DBP"}]},{"database":"OpenTargets","id":"ENSG00000105516","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000105516","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000162136","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_147730_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"EYEHPSS","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"6022300at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"DBP","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 19"}]},{"database":"Bgee","id":"ENSG00000105516","properties":[{"key":"ExpressionPatterns","value":"Expressed in right hemisphere of cerebellum and 179 other cell types or tissues"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0003700","properties":[{"key":"GoTerm","value":"F:DNA-binding transcription factor activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006357","properties":[{"key":"GoTerm","value":"P:regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd14695","properties":[{"key":"EntryName","value":"bZIP_HLF"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.5.170:FF:000007","properties":[{"key":"EntryName","value":"hepatic leukemia factor isoform X2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.5.170","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR004827","properties":[{"key":"EntryName","value":"bZIP"}]},{"database":"InterPro","id":"IPR046347","properties":[{"key":"EntryName","value":"bZIP_sf"}]},{"database":"InterPro","id":"IPR040223","properties":[{"key":"EntryName","value":"PAR_bZIP"}]},{"database":"PANTHER","id":"PTHR11988:SF7","properties":[{"key":"EntryName","value":"D SITE-BINDING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11988","properties":[{"key":"EntryName","value":"THYROTROPH EMBRYONIC FACTOR RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07716","properties":[{"key":"EntryName","value":"bZIP_2"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00338","properties":[{"key":"EntryName","value":"BRLZ"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57959","properties":[{"key":"EntryName","value":"Leucine zipper domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50217","properties":[{"key":"EntryName","value":"BZIP"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MTFEPDPADLALSSIPGHETFDPRRHRFSEEELKPQPIMKKARKIQVPEEQKDEKYWSRRYKNNEAAKRSRDARRLKENQISVRAAFLEKENALLRQEVVAVRQELSHYRAVLSRYQAQHGAL","length":123,"molWeight":14541,"crc64":"96D061822B2496DF","md5":"6E3B8195830C7153699DCE79FDEB2A03"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Domain":1,"Region":1},"uniParcId":"UPI00005BEE28"}}]}