{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P10632","secondaryAccessions":["A8K9N8","B0AZN2","B7Z1F6","Q5VX93","Q8WWB1","Q9UCZ9"],"uniProtkbId":"CP2C8_HUMAN","entryAudit":{"firstPublicDate":"1989-07-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1990-11-01","entryVersion":243,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"26427316"}],"value":"Cytochrome P450 2C8"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11093772"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14559847"}],"value":"1.14.14.1"}]},"alternativeNames":[{"fullName":{"value":"CYPIIC8"}},{"fullName":{"value":"Cytochrome P450 IIC2"}},{"fullName":{"value":"Cytochrome P450 MP-12"}},{"fullName":{"value":"Cytochrome P450 MP-20"}},{"fullName":{"value":"Cytochrome P450 form 1"}},{"fullName":{"value":"S-mephenytoin 4-hydroxylase"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"7574697"},{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:2622"}],"value":"CYP2C8"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11093772"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14559847"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15766564"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19965576"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26427316"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7574697"}],"value":"A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins (PubMed:11093772, PubMed:14559847, PubMed:15766564, PubMed:19965576, PubMed:7574697). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:11093772, PubMed:14559847, PubMed:15766564, PubMed:19965576, PubMed:7574697). Primarily catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA) with a preference for the last double bond (PubMed:15766564, PubMed:19965576, PubMed:7574697). Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes all trans-retinoic acid toward its 4-hydroxylated form (PubMed:11093772). Displays 16-alpha hydroxylase activity toward estrogen steroid hormones, 17beta-estradiol (E2) and estrone (E1) (PubMed:14559847). Plays a role in the oxidative metabolism of xenobiotics. 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CYP2C8 genetic variations are associated with altered drug metabolism and adverse drug effects including acute rhabdomyolysis after cerivastatin use [MIM:618018]"}],"commentType":"POLYMORPHISM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the cytochrome P450 family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Alternative splicing has been shown to occur but the shorter forms are believed to be non-functional"}],"commentType":"CAUTION"},{"commentType":"WEB RESOURCE","resourceName":"PharmVar Pharmacogen Variation Consortium","resourceUrl":"https://www.pharmvar.org/gene/CYP2C8","ftp":false,"note":"CYP2C8 alleles"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":490,"modifier":"EXACT"}},"description":"Cytochrome P450 2C8","featureId":"PRO_0000051699"},{"type":"Binding 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