{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"O15528","secondaryAccessions":["B2RC61","Q548T3"],"uniProtkbId":"CP27B_HUMAN","entryAudit":{"firstPublicDate":"1998-07-15","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1998-01-01","entryVersion":215,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10518789"}],"value":"1.14.15.18"}]},"alternativeNames":[{"fullName":{"value":"25-OHD-1 alpha-hydroxylase"}},{"fullName":{"value":"25-hydroxyvitamin D(3) 1-alpha-hydroxylase"},"shortNames":[{"value":"VD3 1A hydroxylase"}]},{"fullName":{"value":"Calcidiol 1-monooxygenase"}},{"fullName":{"value":"Cytochrome P450 subfamily XXVIIB polypeptide 1"}},{"fullName":{"value":"Cytochrome P450C1 alpha"}},{"fullName":{"value":"Cytochrome P450VD1-alpha"}},{"fullName":{"value":"Cytochrome p450 27B1"}}],"flag":"Precursor"},"genes":[{"geneName":{"value":"CYP27B1"},"synonyms":[{"value":"CYP1ALPHA"},{"value":"CYP27B"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10518789"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10566658"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12050193"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22862690"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9486994"}],"value":"A cytochrome P450 monooxygenase involved in vitamin D metabolism and in calcium and phosphorus homeostasis. 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