{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"O43927","uniProtkbId":"CXL13_HUMAN","entryAudit":{"firstPublicDate":"2000-05-30","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1998-06-01","entryVersion":198,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"C-X-C motif chemokine 13"}},"alternativeNames":[{"fullName":{"value":"Angie"}},{"fullName":{"value":"B cell-attracting chemokine 1"},"shortNames":[{"value":"BCA-1"}]},{"fullName":{"value":"B lymphocyte chemoattractant"}},{"fullName":{"value":"CXC chemokine BLC"}},{"fullName":{"value":"Small-inducible cytokine B13"}}],"flag":"Precursor"},"genes":[{"geneName":{"value":"CXCL13"},"synonyms":[{"value":"BCA1"},{"value":"BLC"},{"value":"SCYB13"}]}],"comments":[{"texts":[{"value":"Chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils. Does not induce calcium release in B-lymphocytes. Binds to BLR1/CXCR5"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"value":"Highest levels in liver, followed by spleen, lymph node, appendix and stomach. Low levels in salivary gland, mammary gland and fetal spleen"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the intercrine alpha (chemokine CxC) family"}],"commentType":"SIMILARITY"},{"commentType":"WEB RESOURCE","resourceName":"Wikipedia","resourceUrl":"https://en.wikipedia.org/wiki/CXCL13","ftp":false,"note":"CXCL13 entry"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Chain","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":109,"modifier":"EXACT"}},"description":"C-X-C motif chemokine 13","featureId":"PRO_0000005113"},{"type":"Disulfide bond","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":60,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Disulfide bond","location":{"start":{"value":35,"modifier":"EXACT"},"end":{"value":76,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Beta strand","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":26,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7JNY"}]},{"type":"Helix","location":{"start":{"value":31,"modifier":"EXACT"},"end":{"value":33,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7JNY"}]},{"type":"Beta strand","location":{"start":{"value":35,"modifier":"EXACT"},"end":{"value":37,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5CBE"}]},{"type":"Helix","location":{"start":{"value":45,"modifier":"EXACT"},"end":{"value":47,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7JNY"}]},{"type":"Beta strand","location":{"start":{"value":48,"modifier":"EXACT"},"end":{"value":54,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7JNY"}]},{"type":"Beta strand","location":{"start":{"value":56,"modifier":"EXACT"},"end":{"value":58,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6VGJ"}]},{"type":"Beta strand","location":{"start":{"value":60,"modifier":"EXACT"},"end":{"value":62,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5CBE"}]},{"type":"Beta strand","location":{"start":{"value":64,"modifier":"EXACT"},"end":{"value":69,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7JNY"}]},{"type":"Beta strand","location":{"start":{"value":74,"modifier":"EXACT"},"end":{"value":77,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7JNY"}]},{"type":"Helix","location":{"start":{"value":82,"modifier":"EXACT"},"end":{"value":93,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7JNY"}]},{"type":"Turn","location":{"start":{"value":95,"modifier":"EXACT"},"end":{"value":97,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6VGJ"}]},{"type":"Helix","location":{"start":{"value":100,"modifier":"EXACT"},"end":{"value":102,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6VGJ"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0145","category":"Biological process","name":"Chemotaxis"},{"id":"KW-0202","category":"Molecular function","name":"Cytokine"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0395","category":"Biological process","name":"Inflammatory response"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"9486651","citationType":"journal article","authors":["Gunn M.D.","Ngo V.N.","Ansel K.M.","Ekland E.H.","Cyster J.G.","Williams L.T."],"citationCrossReferences":[{"database":"PubMed","id":"9486651"},{"database":"DOI","id":"10.1038/35876"}],"title":"A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1.","publicationDate":"1998","journal":"Nature","firstPage":"799","lastPage":"803","volume":"391"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"]},{"referenceNumber":2,"citation":{"id":"9463416","citationType":"journal article","authors":["Legler D.F.","Loetscher M.","Stuber Roos R.","Clark-Lewis I.","Baggiolini M.","Moser B."],"citationCrossReferences":[{"database":"PubMed","id":"9463416"},{"database":"DOI","id":"10.1084/jem.187.4.655"}],"title":"B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5.","publicationDate":"1998","journal":"J. Exp. Med.","firstPage":"655","lastPage":"660","volume":"187"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"],"referenceComments":[{"value":"Peripheral blood leukocyte","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"CI-3SFGA8E9OJ9LO","citationType":"submission","authors":["Napolitano M.","Spinetti G.","Gaetano C.","Capogrossi C.M."],"publicationDate":"OCT-1997","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"],"referenceComments":[{"value":"Peripheral blood","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Skeletal muscle","type":"TISSUE"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AF044197","properties":[{"key":"ProteinId","value":"AAC14402.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AJ002211","properties":[{"key":"ProteinId","value":"CAA05250.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF029894","properties":[{"key":"ProteinId","value":"AAC17980.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC012589","properties":[{"key":"ProteinId","value":"AAH12589.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS3582.1","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_001358487.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001371558.1"}]},{"database":"RefSeq","id":"NP_006410.1","properties":[{"key":"NucleotideSequenceId","value":"NM_006419.3"}]},{"database":"PDB","id":"5CBA","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"E/F=23-109"}]},{"database":"PDB","id":"5CBE","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.40 A"},{"key":"Chains","value":"E/F=23-109"}]},{"database":"PDB","id":"6VGJ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.52 A"},{"key":"Chains","value":"A/B/C/D/E/F/G=24-109"}]},{"database":"PDB","id":"7JNY","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.88 A"},{"key":"Chains","value":"A=23-109"}]},{"database":"PDBsum","id":"5CBA","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5CBE","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6VGJ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7JNY","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"O43927","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"O43927","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"115814","properties":[{"key":"Interactions","value":"13"}]},{"database":"DIP","id":"DIP-5914N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"O43927","properties":[{"key":"Number of interactors","value":"737"}]},{"database":"IntAct","id":"O43927","properties":[{"key":"Interactions","value":"10"}]},{"database":"MINT","id":"O43927","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-CXCL13","properties":[{"key":"Evidences","value":"10 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000286758","properties":[{"key":"Description","value":"-"}]},{"database":"iPTMnet","id":"O43927","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"O43927","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"CXCL13","properties":[{"key":"Description","value":"-"}]},{"database":"CPTAC","id":"CPTAC-5936","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"O43927","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000286758","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"O43927","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"49240","properties":[{"key":"Description","value":"-"}]},{"database":"ABCD","id":"O43927","properties":[{"key":"antibodies","value":"4 sequenced antibodies"}]},{"database":"Antibodypedia","id":"13544","properties":[{"key":"antibodies","value":"605 antibodies from 42 providers"}]},{"database":"CPTC","id":"O43927","properties":[{"key":"antibodies","value":"1 antibody"}]},{"database":"DNASU","id":"10563","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000286758.4","properties":[{"key":"ProteinId","value":"ENSP00000286758.4"},{"key":"GeneId","value":"ENSG00000156234.8"}]},{"database":"Ensembl","id":"ENST00000682537.1","properties":[{"key":"ProteinId","value":"ENSP00000507688.1"},{"key":"GeneId","value":"ENSG00000156234.8"}]},{"database":"GeneID","id":"10563","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:10563","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000682537.1","properties":[{"key":"ProteinId","value":"ENSP00000507688.1"},{"key":"RefSeqNucleotideId","value":"NM_001371558.1"},{"key":"RefSeqProteinId","value":"NP_001358487.1"}]},{"database":"AGR","id":"HGNC:10639","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA35570","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"10563","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"10563","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"CXCL13","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:10639","properties":[{"key":"GeneName","value":"CXCL13"}]},{"database":"HPA","id":"ENSG00000156234","properties":[{"key":"ExpressionPatterns","value":"Tissue enriched (lymphoid)"}]},{"database":"MIM","id":"605149","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000156234","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000156234","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502SEXJ","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00530000064292","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_143902_2_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"O43927","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"NCRCVKT","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9937393at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"O43927","properties":[{"key":"Number of GO annotations","value":"7 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"O43927","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"O43927","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-380108","properties":[{"key":"PathwayName","value":"Chemokine receptors bind chemokines"}]},{"database":"Reactome","id":"R-HSA-418594","properties":[{"key":"PathwayName","value":"G alpha (i) signalling events"}]},{"database":"SignaLink","id":"O43927","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000156234","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"10563","properties":[{"key":"hits","value":"11 hits in 1131 CRISPR screens"}]},{"database":"ChiTaRS","id":"CXCL13","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"O43927","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"CXCL13","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"10563","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"O43927","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:O43927","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 4"}]},{"database":"RNAct","id":"O43927","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000156234","properties":[{"key":"ExpressionPatterns","value":"Expressed in spleen and 133 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"O43927","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17562761"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17652619"}]},{"database":"GO","id":"GO:0031735","properties":[{"key":"GoTerm","value":"F:CCR10 chemokine receptor binding"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10706668"}]},{"database":"GO","id":"GO:0008009","properties":[{"key":"GoTerm","value":"F:chemokine activity"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11554781"}]},{"database":"GO","id":"GO:0045236","properties":[{"key":"GoTerm","value":"F:CXCR chemokine receptor binding"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0048248","properties":[{"key":"GoTerm","value":"F:CXCR3 chemokine receptor binding"},{"key":"GoEvidenceType","value":"IPI:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"11554781"}]},{"database":"GO","id":"GO:0031724","properties":[{"key":"GoTerm","value":"F:CXCR5 chemokine receptor binding"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"9463416"}]},{"database":"GO","id":"GO:0017134","properties":[{"key":"GoTerm","value":"F:fibroblast growth factor binding"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11708770"}]},{"database":"GO","id":"GO:0008201","properties":[{"key":"GoTerm","value":"F:heparin binding"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11708770"}]},{"database":"GO","id":"GO:0048018","properties":[{"key":"GoTerm","value":"F:receptor ligand activity"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11554781"}]},{"database":"GO","id":"GO:0061844","properties":[{"key":"GoTerm","value":"P:antimicrobial humoral immune response mediated by antimicrobial peptide"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0035754","properties":[{"key":"GoTerm","value":"P:B cell chemotaxis"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"9463416"}]},{"database":"GO","id":"GO:0007166","properties":[{"key":"GoTerm","value":"P:cell surface receptor signaling pathway"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11554781"}]},{"database":"GO","id":"GO:0007267","properties":[{"key":"GoTerm","value":"P:cell-cell signaling"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11554781"}]},{"database":"GO","id":"GO:0071222","properties":[{"key":"GoTerm","value":"P:cellular response to lipopolysaccharide"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0070098","properties":[{"key":"GoTerm","value":"P:chemokine-mediated signaling pathway"},{"key":"GoEvidenceType","value":"ISS:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"PubMed","id":"15972452"}]},{"database":"GO","id":"GO:0002544","properties":[{"key":"GoTerm","value":"P:chronic inflammatory response"},{"key":"GoEvidenceType","value":"NAS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15284119"}]},{"database":"GO","id":"GO:0042742","properties":[{"key":"GoTerm","value":"P:defense response to bacterium"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17562761"}]},{"database":"GO","id":"GO:0035768","properties":[{"key":"GoTerm","value":"P:endothelial cell chemotaxis to fibroblast growth factor"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11708770"}]},{"database":"GO","id":"GO:0002467","properties":[{"key":"GoTerm","value":"P:germinal center formation"},{"key":"GoEvidenceType","value":"NAS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16543475"}]},{"database":"GO","id":"GO:0006955","properties":[{"key":"GoTerm","value":"P:immune response"},{"key":"GoEvidenceType","value":"IC:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"11554781"}]},{"database":"GO","id":"GO:0006954","properties":[{"key":"GoTerm","value":"P:inflammatory response"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0002518","properties":[{"key":"GoTerm","value":"P:lymphocyte chemotaxis across high endothelial venule"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:2000545","properties":[{"key":"GoTerm","value":"P:negative regulation of endothelial cell chemotaxis to fibroblast growth factor"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11708770"}]},{"database":"GO","id":"GO:0030593","properties":[{"key":"GoTerm","value":"P:neutrophil chemotaxis"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0033634","properties":[{"key":"GoTerm","value":"P:positive regulation of cell-cell adhesion mediated by integrin"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0007204","properties":[{"key":"GoTerm","value":"P:positive regulation of cytosolic calcium ion concentration"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11554781"}]},{"database":"GO","id":"GO:0033625","properties":[{"key":"GoTerm","value":"P:positive regulation of integrin activation"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0010820","properties":[{"key":"GoTerm","value":"P:positive regulation of T cell chemotaxis"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11554781"}]},{"database":"GO","id":"GO:0045765","properties":[{"key":"GoTerm","value":"P:regulation of angiogenesis"},{"key":"GoEvidenceType","value":"NAS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11708770"}]},{"database":"GO","id":"GO:0002920","properties":[{"key":"GoTerm","value":"P:regulation of humoral immune response"},{"key":"GoEvidenceType","value":"NAS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16531331"}]},{"database":"GO","id":"GO:0032487","properties":[{"key":"GoTerm","value":"P:regulation of Rap protein signal transduction"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"CDD","id":"cd00273","properties":[{"key":"EntryName","value":"Chemokine_CXC"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.40.50.40:FF:000004","properties":[{"key":"EntryName","value":"C-X-C motif chemokine"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.40.50.40","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR039809","properties":[{"key":"EntryName","value":"Chemokine_b/g/d"}]},{"database":"InterPro","id":"IPR001089","properties":[{"key":"EntryName","value":"Chemokine_CXC"}]},{"database":"InterPro","id":"IPR018048","properties":[{"key":"EntryName","value":"Chemokine_CXC_CS"}]},{"database":"InterPro","id":"IPR001811","properties":[{"key":"EntryName","value":"Chemokine_IL8-like_dom"}]},{"database":"InterPro","id":"IPR033899","properties":[{"key":"EntryName","value":"CXC_Chemokine_domain"}]},{"database":"InterPro","id":"IPR036048","properties":[{"key":"EntryName","value":"Interleukin_8-like_sf"}]},{"database":"PANTHER","id":"PTHR12015:SF204","properties":[{"key":"EntryName","value":"C-X-C MOTIF CHEMOKINE 13"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR12015","properties":[{"key":"EntryName","value":"SMALL INDUCIBLE CYTOKINE A"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00048","properties":[{"key":"EntryName","value":"IL8"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00436","properties":[{"key":"EntryName","value":"INTERLEUKIN8"}]},{"database":"PRINTS","id":"PR00437","properties":[{"key":"EntryName","value":"SMALLCYTKCXC"}]},{"database":"SMART","id":"SM00199","properties":[{"key":"EntryName","value":"SCY"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54117","properties":[{"key":"EntryName","value":"Interleukin 8-like chemokines"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00471","properties":[{"key":"EntryName","value":"SMALL_CYTOKINES_CXC"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MKFISTSLLLMLLVSSLSPVQGVLEVYYTSLRCRCVQESSVFIPRRFIDRIQILPRGNGCPRKEIIVWKKNKSIVCVDPQAEWIQRMMEVLRKRSSSTLPVPVFKRKIP","length":109,"molWeight":12664,"crc64":"4057FCA8EFF658A8","md5":"D2AABE8688462D7B851DD05AFCCAD514"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1,"SIMILARITY":1,"WEB RESOURCE":1},"countByFeatureType":{"Signal":1,"Chain":1,"Disulfide bond":2,"Beta strand":7,"Helix":4,"Turn":1},"uniParcId":"UPI0000000CC9"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q53X90","secondaryAccessions":["A0A024RDB7"],"uniProtkbId":"Q53X90_HUMAN","entryAudit":{"firstPublicDate":"2005-05-24","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2005-05-24","entryVersion":166,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAG28552.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361149"}],"value":"C-X-C motif chemokine"}},"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAG28552.1"}],"value":"CXCL13"},"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"EAX05816.1"}],"value":"hCG_22991"}]}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004613"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361149"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00010665"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361149"}],"value":"Belongs to the intercrine alpha (chemokine CxC) family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361149"}]},{"type":"Chain","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":109,"modifier":"EXACT"}},"description":"C-X-C motif chemokine","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361149"}],"featureId":"PRO_5014205859"},{"type":"Domain","location":{"start":{"value":30,"modifier":"EXACT"},"end":{"value":91,"modifier":"EXACT"}},"description":"Chemokine interleukin-8-like","evidences":[{"evidenceCode":"ECO:0000259","source":"SMART","id":"SM00199"}]},{"type":"Non-terminal residue","location":{"start":{"value":109,"modifier":"EXACT"},"end":{"value":109,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAG28552.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361149"}],"id":"KW-0145","category":"Biological process","name":"Chemotaxis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022514"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361149"}],"id":"KW-0202","category":"Molecular function","name":"Cytokine"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361149"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361149"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"11181995","citationType":"journal article","authors":["Venter J.C.","Adams M.D.","Myers E.W.","Li P.W.","Mural R.J.","Sutton G.G.","Smith H.O.","Yandell M.","Evans C.A.","Holt R.A.","Gocayne J.D.","Amanatides P.","Ballew R.M.","Huson D.H.","Wortman J.R.","Zhang Q.","Kodira C.D.","Zheng X.H.","Chen L.","Skupski M.","Subramanian G.","Thomas P.D.","Zhang J.","Gabor Miklos G.L.","Nelson C.","Broder S.","Clark A.G.","Nadeau J.","McKusick V.A.","Zinder N.","Levine A.J.","Roberts R.J.","Simon M.","Slayman C.","Hunkapiller M.","Bolanos R.","Delcher A.","Dew I.","Fasulo D.","Flanigan M.","Florea L.","Halpern A.","Hannenhalli S.","Kravitz S.","Levy S.","Mobarry C.","Reinert K.","Remington K.","Abu-Threideh J.","Beasley E.","Biddick K.","Bonazzi V.","Brandon R.","Cargill M.","Chandramouliswaran I.","Charlab R.","Chaturvedi K.","Deng Z.","Di Francesco V.","Dunn P.","Eilbeck K.","Evangelista C.","Gabrielian A.E.","Gan W.","Ge W.","Gong F.","Gu Z.","Guan P.","Heiman T.J.","Higgins M.E.","Ji R.R.","Ke Z.","Ketchum K.A.","Lai Z.","Lei Y.","Li Z.","Li J.","Liang Y.","Lin X.","Lu F.","Merkulov G.V.","Milshina N.","Moore H.M.","Naik A.K.","Narayan V.A.","Neelam B.","Nusskern D.","Rusch D.B.","Salzberg S.","Shao W.","Shue B.","Sun J.","Wang Z.","Wang A.","Wang X.","Wang J.","Wei M.","Wides R.","Xiao C.","Yan C.","Yao A.","Ye J.","Zhan M.","Zhang W.","Zhang H.","Zhao Q.","Zheng L.","Zhong F.","Zhong W.","Zhu S.","Zhao S.","Gilbert D.","Baumhueter S.","Spier G.","Carter C.","Cravchik A.","Woodage T.","Ali F.","An H.","Awe A.","Baldwin D.","Baden H.","Barnstead M.","Barrow I.","Beeson K.","Busam D.","Carver A.","Center A.","Cheng M.L.","Curry L.","Danaher S.","Davenport L.","Desilets R.","Dietz S.","Dodson K.","Doup L.","Ferriera S.","Garg N.","Gluecksmann A.","Hart B.","Haynes J.","Haynes C.","Heiner C.","Hladun S.","Hostin D.","Houck J.","Howland T.","Ibegwam C.","Johnson J.","Kalush F.","Kline L.","Koduru S.","Love A.","Mann F.","May D.","McCawley S.","McIntosh T.","McMullen I.","Moy M.","Moy L.","Murphy B.","Nelson K.","Pfannkoch C.","Pratts E.","Puri V.","Qureshi H.","Reardon M.","Rodriguez R.","Rogers Y.H.","Romblad D.","Ruhfel B.","Scott R.","Sitter C.","Smallwood M.","Stewart E.","Strong R.","Suh E.","Thomas R.","Tint N.N.","Tse S.","Vech C.","Wang G.","Wetter J.","Williams S.","Williams M.","Windsor S.","Winn-Deen E.","Wolfe K.","Zaveri J.","Zaveri K.","Abril J.F.","Guigo R.","Campbell M.J.","Sjolander K.V.","Karlak B.","Kejariwal A.","Mi H.","Lazareva B.","Hatton T.","Narechania A.","Diemer K.","Muruganujan A.","Guo N.","Sato S.","Bafna V.","Istrail S.","Lippert R.","Schwartz R.","Walenz B.","Yooseph S.","Allen D.","Basu A.","Baxendale J.","Blick L.","Caminha M.","Carnes-Stine J.","Caulk P.","Chiang Y.H.","Coyne M.","Dahlke C.","Mays A.","Dombroski M.","Donnelly M.","Ely D.","Esparham S.","Fosler C.","Gire H.","Glanowski S.","Glasser K.","Glodek A.","Gorokhov M.","Graham K.","Gropman B.","Harris M.","Heil J.","Henderson S.","Hoover J.","Jennings D.","Jordan C.","Jordan J.","Kasha J.","Kagan L.","Kraft C.","Levitsky A.","Lewis M.","Liu X.","Lopez J.","Ma D.","Majoros W.","McDaniel J.","Murphy S.","Newman M.","Nguyen T.","Nguyen N.","Nodell M.","Pan S.","Peck J.","Peterson M.","Rowe W.","Sanders R.","Scott J.","Simpson M.","Smith T.","Sprague A.","Stockwell T.","Turner R.","Venter E.","Wang M.","Wen M.","Wu D.","Wu M.","Xia A.","Zandieh A.","Zhu X."],"citationCrossReferences":[{"database":"PubMed","id":"11181995"},{"database":"DOI","id":"10.1126/science.1058040"}],"title":"The sequence of the human genome.","publicationDate":"2001","journal":"Science","firstPage":"1304","lastPage":"1351","volume":"291"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"EAX05816.1"}]},{"referenceNumber":2,"citation":{"id":"CI-D49PLCHMKUIEL","citationType":"submission","authors":["Ebert L.","Schick M.","Neubert P.","Schatten R.","Henze S.","Korn B."],"title":"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201).","publicationDate":"MAY-2004","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAG28552.1"}]},{"referenceNumber":3,"citation":{"id":"CI-56FT96O07V0QG","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"JUL-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"EAX05816.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"CR407624","properties":[{"key":"ProteinId","value":"CAG28552.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"CH471057","properties":[{"key":"ProteinId","value":"EAX05816.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"NP_001358487.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001371558.1"}]},{"database":"RefSeq","id":"NP_006410.1","properties":[{"key":"NucleotideSequenceId","value":"NM_006419.3"}]},{"database":"AlphaFoldDB","id":"Q53X90","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q53X90","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"13544","properties":[{"key":"antibodies","value":"605 antibodies from 42 providers"}]},{"database":"DNASU","id":"10563","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"10563","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:10563","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc003hkr.5","properties":[{"key":"OrganismName","value":"human"}]},{"database":"ClinPGx","id":"PA35570","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"10563","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"10563","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000156234","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_143902_2_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"NCRCVKT","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9937393at2759","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"10563","properties":[{"key":"hits","value":"11 hits in 1131 CRISPR screens"}]},{"database":"ChiTaRS","id":"CXCL13","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0008009","properties":[{"key":"GoTerm","value":"F:chemokine activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006952","properties":[{"key":"GoTerm","value":"P:defense response"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006955","properties":[{"key":"GoTerm","value":"P:immune response"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd00273","properties":[{"key":"EntryName","value":"Chemokine_CXC"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.40.50.40:FF:000004","properties":[{"key":"EntryName","value":"C-X-C motif chemokine"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.40.50.40","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR039809","properties":[{"key":"EntryName","value":"Chemokine_b/g/d"}]},{"database":"InterPro","id":"IPR001089","properties":[{"key":"EntryName","value":"Chemokine_CXC"}]},{"database":"InterPro","id":"IPR018048","properties":[{"key":"EntryName","value":"Chemokine_CXC_CS"}]},{"database":"InterPro","id":"IPR001811","properties":[{"key":"EntryName","value":"Chemokine_IL8-like_dom"}]},{"database":"InterPro","id":"IPR033899","properties":[{"key":"EntryName","value":"CXC_Chemokine_domain"}]},{"database":"InterPro","id":"IPR036048","properties":[{"key":"EntryName","value":"Interleukin_8-like_sf"}]},{"database":"PANTHER","id":"PTHR12015:SF204","properties":[{"key":"EntryName","value":"C-X-C MOTIF CHEMOKINE 13"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR12015","properties":[{"key":"EntryName","value":"SMALL INDUCIBLE CYTOKINE A"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00048","properties":[{"key":"EntryName","value":"IL8"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00436","properties":[{"key":"EntryName","value":"INTERLEUKIN8"}]},{"database":"PRINTS","id":"PR00437","properties":[{"key":"EntryName","value":"SMALLCYTKCXC"}]},{"database":"SMART","id":"SM00199","properties":[{"key":"EntryName","value":"SCY"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54117","properties":[{"key":"EntryName","value":"Interleukin 8-like chemokines"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00471","properties":[{"key":"EntryName","value":"SMALL_CYTOKINES_CXC"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MKFISTSLLLMLLVSSLSPVQGVLEVYYTSLRCRCVQESSVFIPRRFIDRIQILPRGNGCPRKEIIVWKKNKSIVCVDPQAEWIQRMMEVLRKRSSSTLPVPVFKRKIP","length":109,"molWeight":12664,"crc64":"4057FCA8EFF658A8","md5":"D2AABE8688462D7B851DD05AFCCAD514"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":1,"Non-terminal residue":1},"uniParcId":"UPI0000000CC9"}}]}