{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P46108","secondaryAccessions":["A8MWE8","B0LPE8","D3DTH6","Q96GA9","Q96HJ0"],"uniProtkbId":"CRK_HUMAN","entryAudit":{"firstPublicDate":"1995-11-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2007-07-24","entryVersion":241,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Adapter molecule crk"}},"alternativeNames":[{"fullName":{"value":"Proto-oncogene c-Crk"}},{"fullName":{"value":"p38"}}]},"genes":[{"geneName":{"value":"CRK"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12432078"}],"value":"Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q64010"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11870224"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1630456"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17515907"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19004829"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31311869"}],"value":"Regulates cell adhesion, spreading and migration (PubMed:31311869). Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4 (PubMed:19004829). May regulate the EFNA5-EPHA3 signaling (By similarity)"}],"commentType":"FUNCTION","molecule":"Isoform Crk-II"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10362357"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10964504"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12384576"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12432078"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12628187"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12878163"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16076871"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17038317"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18024423"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19381274"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19807924"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20534451"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8657152"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8662907"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9614078"}],"value":"Component of a complex comprised of SH2D3C, BCAR1/CAS, and CRK (PubMed:12432078). Within the complex, interacts with SH2D3C (via C-terminus), and BCAR1/CAS (PubMed:12432078). Found in a complex with ABL1, ABL2, CRK and UNC119; leading to the inhibition of CRK phosphorylation by ABL kinases (PubMed:19381274). Interacts with ABL1, C3G, DOCK3, DOCK5, MAP4K1, MAPK8 and SOS via its first SH3 domain. Interacts (via SH2 domain) with BCAR1, CBL, CBLB, PXN, IRS4 and GAB1 upon stimulus-induced tyrosine phosphorylation. Interacts (via SH2 domain) with several tyrosine-phosphorylated growth factor receptors such as EGFR and INSR. Interacts with FLT1 (tyrosine-phosphorylated). Interacts with DOCK1 and DOCK4. Interacts with SHB. Interacts with PEAK1. Interacts with FASLG. Part of a collagen stimulated complex involved in cell migration composed of CDC42, CRK, TNK2 and p130cas/BCAR1. Interacts (via SH2 domain) with the 'Tyr-9' phosphorylated form of PDPK1. Interacts with CBLC"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10733900"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11870224"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12878163"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31311869"}],"value":"Interacts (via SH2 domain) with PDGFRA (tyrosine phosphorylated) and PDGFRB (tyrosine phosphorylated) (PubMed:10733900). Interacts with EPHA3 (phosphorylated); upon activation of EPHA3 by the ligand EFNA5 and EPHA3 tyrosine kinase activity-dependent and mediates EFNA5-EPHA3 signaling through RHOA GTPase activation (PubMed:11870224). Interacts with KIT (PubMed:12878163). Interacts with PEAK3; the interaction requires PEAK3 homodimerization (PubMed:31311869)"}],"commentType":"SUBUNIT","molecule":"Isoform Crk-II"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P46108","intActId":"EBI-886"},"interactantTwo":{"uniProtKBAccession":"P00519","geneName":"ABL1","intActId":"EBI-375543"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P46108","intActId":"EBI-886"},"interactantTwo":{"uniProtKBAccession":"P42684","geneName":"ABL2","intActId":"EBI-1102694"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P46108","intActId":"EBI-886"},"interactantTwo":{"uniProtKBAccession":"A7KAX9","geneName":"ARHGAP32","intActId":"EBI-308663"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P46108","intActId":"EBI-886"},"interactantTwo":{"uniProtKBAccession":"O15085","geneName":"ARHGEF11","intActId":"EBI-311099"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P46108","intActId":"EBI-886"},"interactantTwo":{"uniProtKBAccession":"Q9ULH1","geneName":"ASAP1","intActId":"EBI-346622"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P46108","intActId":"EBI-886"},"interactantTwo":{"uniProtKBAccession":"Q8TDY4","geneName":"ASAP3","intActId":"EBI-2609717"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P46108","intActId":"EBI-886"},"interactantTwo":{"uniProtKBAccession":"Q96DX5","geneName":"ASB9","intActId":"EBI-745641"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P46108","intActId":"EBI-886"},"interactantTwo":{"uniProtKBAccession":"P54253","geneName":"ATXN1","intActId":"EBI-930964"},"numberOfExperiments":9,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P46108","intActId":"EBI-886"},"interactantTwo":{"uniProtKBAccession":"P56945","geneName":"BCAR1","intActId":"EBI-702093"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P46108","intActId":"EBI-886"},"interactantTwo":{"uniProtKBAccession":"Q9NZM4","geneName":"BICRA","intActId":"EBI-1754943"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P46108","intActId":"EBI-886"},"interactantTwo":{"uniProtKBAccession":"O43683","geneName":"BUB1","intActId":"EBI-748936"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P46108","intActId":"EBI-886"},"interactantTwo":{"uniProtKBAccession":"Q6P1W5","geneName":"C1orf94","intActId":"EBI-946029"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P46108","intActId":"EBI-886"},"interactantTwo":{"uniProtKBAccession":"P22681","geneName":"CBL","intActId":"EBI-518228"},"numberOfExperiments":11,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P46108","intActId":"EBI-886"},"interactantTwo":{"uniProtKBAccession":"Q13191","geneName":"CBLB","intActId":"EBI-744027"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P46108","intActId":"EBI-886"},"interactantTwo":{"uniProtKBAccession":"Q14185","geneName":"DOCK1","intActId":"EBI-446740"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P46108","intActId":"EBI-886"},"interactantTwo":{"uniProtKBAccession":"Q9H7D0","geneName":"DOCK5","intActId":"EBI-1773858"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P46108","intActId":"EBI-886"},"interactantTwo":{"uniProtKBAccession":"Q7L190","geneName":"DPPA4","intActId":"EBI-710457"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P46108","intActId":"EBI-886"},"interactantTwo":{"uniProtKBAccession":"P00533","geneName":"EGFR","intActId":"EBI-297353"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P46108","intActId":"EBI-886"},"interactantTwo":{"uniProtKBAccession":"P41970","geneName":"ELK3","intActId":"EBI-1758534"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P46108","intActId":"EBI-886"},"interactantTwo":{"uniProtKBAccession":"P21860","geneName":"ERBB3","intActId":"EBI-720706"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P46108","intActId":"EBI-886"},"interactantTwo":{"uniProtKBAccession":"Q96Q35-2","geneName":"FLACC1","intActId":"EBI-11533409"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P46108","intActId":"EBI-886"},"interactantTwo":{"uniProtKBAccession":"P21333","geneName":"FLNA","intActId":"EBI-350432"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P46108","intActId":"EBI-886"},"interactantTwo":{"uniProtKBAccession":"Q14315","geneName":"FLNC","intActId":"EBI-489954"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P46108","intActId":"EBI-886"},"interactantTw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phosphorylated proteins. 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