{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P02462","secondaryAccessions":["A7E2W4","B1AM70","F5H5K0","Q1P9S9","Q5VWF6","Q86X41","Q8NF88","Q9NYC5"],"uniProtkbId":"CO4A1_HUMAN","entryAudit":{"firstPublicDate":"1986-07-21","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2018-05-23","entryVersion":243,"sequenceVersion":4},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Collagen alpha-1(IV) chain"}},"contains":[{"recommendedName":{"fullName":{"value":"Arresten"}}}],"flag":"Precursor"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:2202"}],"value":"COL4A1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P02463"}],"value":"Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10811134"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18775695"}],"value":"Arresten, comprising the C-terminal NC1 domain, inhibits angiogenesis and tumor formation. 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