{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q00610","secondaryAccessions":["D3DU00","Q6N0A0","Q86TF2"],"uniProtkbId":"CLH1_HUMAN","entryAudit":{"firstPublicDate":"1992-12-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2007-01-23","entryVersion":239,"sequenceVersion":5},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"26822784"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"29100083"}],"value":"Clathrin heavy chain 1"}},"alternativeNames":[{"fullName":{"value":"Clathrin heavy chain on chromosome 17"},"shortNames":[{"value":"CLH-17"}]}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"26822784"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"29100083"},{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:2092"}],"value":"CLTC"},"synonyms":[{"value":"CLH17"},{"value":"CLTCL2"},{"value":"KIAA0034"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P49951"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15858577"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16968737"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20639872"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21297582"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23532825"}],"value":"Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:16968737, PubMed:21297582). The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Plays a role in early autophagosome formation (PubMed:20639872). Interaction with DNAJC6 mediates the recruitment of HSPA8 to the clathrin lattice and creates local destabilization of the lattice promoting uncoating (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P49951"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q68FD5"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11532990"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16314522"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16968737"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18529014"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20639872"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21266579"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21297582"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25066864"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26756164"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27022195"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29735704"}],"value":"Clathrin triskelions, composed of 3 heavy chains and 3 light chains, are the basic subunits of the clathrin coat (PubMed:16968737). In the presence of light chains, hub assembly is influenced by both the pH and the concentration of calcium. Interacts with HIP1 (PubMed:11532990). Interacts with DENND1A, DENND1B and DENND1C (By similarity). May interact with OCRL (By similarity). Interacts with ERBB2 (PubMed:16314522). Interacts with FKBP6 (PubMed:18529014). Interacts with CKAP5 and TACC3 forming the TACC3/ch-TOG/clathrin complex located at spindle inter-microtubules bridges; the complex implicates clathrin triskelions; TACC3 and CLTC are proposed to form a composite microtubule interaction surface (PubMed:21297582). Interacts with ATG16L1 (via N-terminus) (PubMed:20639872). Interacts with RFTN1; the interaction occurs in response to pathogens (PubMed:21266579, PubMed:27022195). Interacts with USP2 isoform 4 (PubMed:26756164). Interacts with TMEM106B (via N-terminus) (PubMed:25066864). Interacts with DNAJC6; this interaction produces a local change in heavy-chain contacts, creating a detectable global distortion of the clathrin coat and leads to the recruitment of HSPA8 (PubMed:29735704)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q00610","intActId":"EBI-354967"},"interactantTwo":{"uniProtKBAccession":"P32121","geneName":"ARRB2","intActId":"EBI-714559"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q00610","intActId":"EBI-354967"},"interactantTwo":{"uniProtKBAccession":"P09496","geneName":"CLTA","intActId":"EBI-1171169"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q00610","intActId":"EBI-354967"},"interactantTwo":{"uniProtKBAccession":"Q15398","geneName":"DLGAP5","intActId":"EBI-748280"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q00610","intActId":"EBI-354967"},"interactantTwo":{"uniProtKBAccession":"P10242","geneName":"MYB","intActId":"EBI-298355"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q00610","intActId":"EBI-354967"},"interactantTwo":{"uniProtKBAccession":"Q01968","geneName":"OCRL","intActId":"EBI-6148898"},"numberOfExperiments":10,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q00610","intActId":"EBI-354967"},"interactantTwo":{"uniProtKBAccession":"Q9H8K7","geneName":"PAAT","intActId":"EBI-714785"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q00610","intActId":"EBI-354967"},"interactantTwo":{"uniProtKBAccession":"Q07912","geneName":"TNK2","intActId":"EBI-603457"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q00610","intActId":"EBI-354967"},"interactantTwo":{"uniProtKBAccession":"O75674","geneName":"TOM1L1","intActId":"EBI-712991"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q00610","intActId":"EBI-354967"},"interactantTwo":{"uniProtKBAccession":"Q306W6","intActId":"EBI-38815211"},"numberOfExperiments":4,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"Q00610","intActId":"EBI-354967"},"interactantTwo":{"uniProtKBAccession":"Q306W8","intActId":"EBI-38259300"},"numberOfExperiments":2,"organismDiffer":true}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25596274"}],"value":"Cytoplasmic face of coated pits and vesicles. 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