{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P17787","secondaryAccessions":["Q9UEH9"],"uniProtkbId":"ACHB2_HUMAN","entryAudit":{"firstPublicDate":"1990-08-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1990-08-01","entryVersion":235,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Neuronal acetylcholine receptor subunit beta-2"}},"flag":"Precursor"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:1962"}],"value":"CHRNB2"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P12390"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16835356"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20881005"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22361591"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27698419"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29720657"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33239400"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38161283"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38454578"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8663494"}],"value":"Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators (PubMed:22361591, PubMed:27698419, PubMed:29720657, PubMed:38454578). CHRNB2 forms heteropentameric neuronal acetylcholine receptors with CHRNA2, CHRNA3, CHRNA4 and CHRNA6, as well as CHRNA5 and CHRNB3 as accesory subunits (PubMed:16835356, PubMed:20881005, PubMed:22361591, PubMed:27698419, PubMed:29720657, PubMed:38454578, PubMed:8663494). Found in two major stoichiometric forms,(CHRNA4)3:(CHRNB2)2 and (CHRNA4)2:(CHRNB2)3, the two stoichiometric forms differ in their unitary conductance, calcium permeability, ACh sensitivity and potentiation by divalent cation (PubMed:27698419, PubMed:29720657, PubMed:38454578). Heteropentameric channels with CHRNA6 and CHRNA4 exhibit high sensitivity to ACh and nicotine and are predominantly expressed in only a few brain areas, including dopaminergic neurons, norepirephrine neurons and cells of the visual system. nAChrs containing CHRNA6 subunits mediate endogenous cholinergic modulation of dopamine and gamma-aminobutyric acid (GABA) release in response to nicotine at nerve terminals (By similarity). Also forms functional nAChRs with other subunits such as CHRNA7:CHRNB2, mainly expressed in basal forebrain cholinergic neurons (PubMed:33239400, PubMed:38161283)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"Ca(2+)(in) = Ca(2+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29671"},{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17132685"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20881005"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"K(+)(in) = K(+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29463"},{"database":"ChEBI","id":"CHEBI:29103"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P04758"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"Na(+)(in) = Na(+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:34963"},{"database":"ChEBI","id":"CHEBI:29101"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22361591"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38454578"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12527804"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15609996"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16835356"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17132685"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20881005"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27698419"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29720657"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33239400"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38161283"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38454578"}],"value":"Activated by a myriad of ligands such as acetylcholine, cytisine, nicotine, choline and epibatidine (PubMed:12527804, PubMed:16835356, PubMed:17132685, PubMed:20881005, PubMed:27698419, PubMed:29720657, PubMed:38454578). Channel potentiation by calcium is stoichiometry-selective, CHRNA4:CHRNB2 nACh receptor is achieved by calcium association with topographically distinct sites framed by anionic residues within the CHRNA4 subunit and between the CHRNA4 and CHRNB2 subunits (PubMed:38454578). Oligomeric amyloid-beta protein 42 activates specifially CHRNA7:CHRNB2 nAchRs (PubMed:33239400). nAChR activity is inhibited by the antagonist alpha-conotoxins BuIA, PnIA, PnIC, GID and MII, small disulfide-constrained peptides from cone snails (PubMed:15609996, PubMed:38161283)"}],"commentType":"ACTIVITY REGULATION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P12390"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12527804"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16120769"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16835356"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17132685"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22361591"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27344019"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27698419"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29720657"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33239400"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38161283"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38454578"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"27493220"}],"value":"Neuronal AChR is a heteropentamer composed of two different types of subunits: alpha and beta. CHRNB2/Beta-2 subunit can be combined to CHRNA2/alpha-2, CHRNA3/alpha-3 or CHRNA4/alpha-4, CHRNA5/alpha-5, CHRNA6/alpha-6 and CHRNB3/beta-3 to give rise to functional receptors. CHRNA2:CHRNB2 and CHRNA4:CHRNB2 nAChR complexes exist in two subtypes: LS (low agonist sensitivity) with a (CHRNA2/4)3:(CHRNB2)2 and HS (high agonist sensitivity) with a (CHRNA2/4)2:(CHRNB2)3 stoichiometry; the subtypes differ in their subunit binding interfaces which are involved in ligand binding (PubMed:12527804, PubMed:16835356, PubMed:17132685, PubMed:22361591, PubMed:27493220, PubMed:27698419, PubMed:29720657, PubMed:38454578). Cells produce predominantly an (CHRNA4)3:(CHRNB2)2 nAChR. The stoichiometric form (CHRNA4)2:(CHRNB2)3 expression is selectively up-regulated by nicotine and has lower single channel conductance and calcium permeability (PubMed:17132685). Also part of the stoichiometric forms: (CHRNA4:CHRNB2)2:CHRNB3 or (CHRNA6:CHRNB2)2:CHRNB3 (PubMed:16835356). Can form heteropentamers with CHRNA7, mainly found in basal forebrain cholinergic neurons (PubMed:33239400, PubMed:38161283). Interacts with RIC3; which is required for proper folding and assembly (PubMed:16120769). Interacts with LYPD6 (PubMed:27344019)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P17787","intActId":"EBI-9008612"},"interactantTwo":{"uniProtKBAccession":"P43681-1","geneName":"CHRNA4","intActId":"EBI-20716158"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P17787","intActId":"EBI-9008612"},"interactantTwo":{"uniProtKBAccession":"P30532","geneName":"CHRNA5","intActId":"EBI-6657490"},"numberOfExperiments":4,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P12390"}],"value":"Synaptic cell membrane","id":"SL-0531"},"topology":{"evidences":[{"evidenceCode":"ECO:0000255"}],"value":"Multi-pass membrane protein","id":"SL-9909"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000255"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"commentType":"DISEASE","disease":{"diseaseId":"Epilepsy, nocturnal frontal lobe, 3","diseaseAccession":"DI-00820","acronym":"ENFL3","description":"An autosomal dominant focal epilepsy characterized by nocturnal seizures with hyperkinetic automatisms and poorly organized stereotyped movements.","diseaseCrossReference":{"database":"MIM","id":"605375"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11062464"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11104662"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta-2/CHRNB2 sub-subfamily"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":25,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Chain","location":{"start":{"value":26,"modifier":"EXACT"},"end":{"value":502,"modifier":"EXACT"}},"description":"Neuronal acetylcholine receptor subunit beta-2","featureId":"PRO_0000000379"},{"type":"Topological domain","location":{"start":{"value":26,"modifier":"EXACT"},"end":{"value":238,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29720657"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6CNJ"}]},{"type":"Transmembrane","location":{"start":{"value":239,"modifier":"EXACT"},"end":{"value":260,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29720657"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6CNJ"}]},{"type":"Topological domain","location":{"start":{"value":261,"modifier":"EXACT"},"end":{"value":265,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29720657"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6CNJ"}]},{"type":"Transmembrane","location":{"start":{"value":266,"modifier":"EXACT"},"end":{"value":282,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29720657"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6CNJ"}]},{"type":"Topological domain","location":{"start":{"value":283,"modifier":"EXACT"},"end":{"value":296,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29720657"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6CNJ"}]},{"type":"Transmembrane","location":{"start":{"value":297,"modifier":"EXACT"},"end":{"value":321,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29720657"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6CNJ"}]},{"type":"Topological domain","location":{"start":{"value":322,"modifier":"EXACT"},"end":{"value":458,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29720657"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6CNJ"}]},{"type":"Transmembrane","location":{"start":{"value":459,"modifier":"EXACT"},"end":{"value":478,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Site","location":{"start":{"value":84,"modifier":"EXACT"},"end":{"value":84,"modifier":"EXACT"}},"description":"Key residue that may interfere with effective access of the conotoxin BuIA to the channel binding site","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P12390"}]},{"type":"Site","location":{"start":{"value":136,"modifier":"EXACT"},"end":{"value":136,"modifier":"EXACT"}},"description":"Key residue for a rapid dissociation (K(off)) from the conotoxin BuIA","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P12390"}]},{"type":"Site","location":{"start":{"value":144,"modifier":"EXACT"},"end":{"value":144,"modifier":"EXACT"}},"description":"Key residue for a rapid dissociation (K(off)) from the conotoxin BuIA","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P12390"}]},{"type":"Glycosylation","location":{"start":{"value":51,"modifier":"EXACT"},"end":{"value":51,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27698419"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5KXI"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":168,"modifier":"EXACT"},"end":{"value":168,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":485,"modifier":"EXACT"},"end":{"value":485,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Disulfide bond","location":{"start":{"value":155,"modifier":"EXACT"},"end":{"value":169,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27698419"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29720657"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38454578"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5KXI"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6CNJ"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6CNK"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8SSZ"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8ST0"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8ST1"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8ST2"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8ST3"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8ST4"}]},{"type":"Natural variant","location":{"start":{"value":287,"modifier":"EXACT"},"end":{"value":287,"modifier":"EXACT"}},"description":"in ENFL3; dbSNP:rs74315291","featureCrossReferences":[{"database":"dbSNP","id":"rs74315291"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11062464"}],"featureId":"VAR_012714","alternativeSequence":{"originalSequence":"V","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":287,"modifier":"EXACT"},"end":{"value":287,"modifier":"EXACT"}},"description":"in ENFL3; approximately 10-fold increase in acetylcholine sensitivity; dbSNP:rs74315291","featureCrossReferences":[{"database":"dbSNP","id":"rs74315291"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11104662"}],"featureId":"VAR_012715","alternativeSequence":{"originalSequence":"V","alternativeSequences":["M"]}},{"type":"Natural variant","location":{"start":{"value":397,"modifier":"EXACT"},"end":{"value":397,"modifier":"EXACT"}},"description":"in dbSNP:rs55685423","featureCrossReferences":[{"database":"dbSNP","id":"rs55685423"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11906688"}],"featureId":"VAR_021564","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["H"]}},{"type":"Mutagenesis","location":{"start":{"value":72,"modifier":"EXACT"},"end":{"value":72,"modifier":"EXACT"}},"description":"Reduces CHRNA4:CHRNB2 channel opening potentiation by divalent cations.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38454578"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":74,"modifier":"EXACT"},"end":{"value":74,"modifier":"EXACT"}},"description":"Reduces CHRNA4:CHRNB2 channel opening potentiation by divalent cations.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38454578"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":196,"modifier":"EXACT"},"end":{"value":196,"modifier":"EXACT"}},"description":"Loss of CHRNA4:CHRNB2 channel opening potentiation by divalent cations.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38454578"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":197,"modifier":"EXACT"},"end":{"value":197,"modifier":"EXACT"}},"description":"Increases ligand activation in LS and HS nAChR subtypes.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27493220"}],"alternativeSequence":{"originalSequence":"F","alternativeSequences":["Y"]}},{"type":"Mutagenesis","location":{"start":{"value":202,"modifier":"EXACT"},"end":{"value":202,"modifier":"EXACT"}},"description":"Reduces CHRNA4:CHRNB2 channel opening potentiation by divalent cations.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38454578"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":218,"modifier":"EXACT"},"end":{"value":218,"modifier":"EXACT"}},"description":"Reduces CHRNA4:CHRNB2 channel opening potentiation by divalent cations.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38454578"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":285,"modifier":"EXACT"},"end":{"value":285,"modifier":"EXACT"}},"description":"Increases Ca(2+) permeability.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17132685"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["E"]}},{"type":"Sequence conflict","location":{"start":{"value":26,"modifier":"EXACT"},"end":{"value":26,"modifier":"EXACT"}},"description":"in Ref. 4; CAA05108","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"T","alternativeSequences":["A"]}},{"type":"Sequence conflict","location":{"start":{"value":426,"modifier":"EXACT"},"end":{"value":426,"modifier":"EXACT"}},"description":"in Ref. 4; CAA05108","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["A"]}},{"type":"Sequence conflict","location":{"start":{"value":446,"modifier":"EXACT"},"end":{"value":446,"modifier":"EXACT"}},"description":"in Ref. 4; CAA05108","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["SVR"]}},{"type":"Helix","location":{"start":{"value":27,"modifier":"EXACT"},"end":{"value":37,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8ST4"}]},{"type":"Turn","location":{"start":{"value":39,"modifier":"EXACT"},"end":{"value":41,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8ST4"}]},{"type":"Beta strand","location":{"start":{"value":50,"modifier":"EXACT"},"end":{"value":53,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8ST4"}]},{"type":"Beta strand","location":{"start":{"value":56,"modifier":"EXACT"},"end":{"value":71,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8ST4"}]},{"type":"Turn","location":{"start":{"value":72,"modifier":"EXACT"},"end":{"value":75,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8ST4"}]},{"type":"Beta strand","location":{"start":{"value":76,"modifier":"EXACT"},"end":{"value":88,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8ST4"}]},{"type":"Helix","location":{"start":{"value":90,"modifier":"EXACT"},"end":{"value":92,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8ST4"}]},{"type":"Helix","location":{"start":{"value":96,"modifier":"EXACT"},"end":{"value":99,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8ST4"}]},{"type":"Beta strand","location":{"start":{"value":104,"modifier":"EXACT"},"end":{"value":108,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8ST4"}]},{"type":"Helix","location":{"start":{"value":109,"modifier":"EXACT"},"end":{"value":111,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8ST4"}]},{"type":"Beta strand","location":{"start":{"value":117,"modifier":"EXACT"},"end":{"value":119,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8ST4"}]},{"type":"Beta strand","location":{"start":{"value":122,"modifier":"EXACT"},"end":{"value":125,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8ST4"}]},{"type":"Beta strand","location":{"start":{"value":134,"modifier":"EXACT"},"end":{"value":138,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8ST4"}]},{"type":"Beta strand","location":{"start":{"value":141,"modifier":"EXACT"},"end":{"value":145,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8ST4"}]},{"type":"Beta strand","location":{"start":{"value":148,"modifier":"EXACT"},"end":{"value":154,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8ST4"}]},{"type":"Helix","location":{"start":{"value":156,"modifier":"EXACT"},"end":{"value":158,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8ST0"}]},{"type":"Turn","location":{"start":{"value":160,"modifier":"EXACT"},"end":{"value":163,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8ST4"}]},{"type":"Beta strand","location":{"start":{"value":166,"modifier":"EXACT"},"end":{"value":177,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8ST4"}]},{"type":"Turn","location":{"start":{"value":180,"modifier":"EXACT"},"end":{"value":182,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8ST4"}]},{"type":"Beta strand","location":{"start":{"value":183,"modifier":"EXACT"},"end":{"value":191,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8ST4"}]},{"type":"Beta strand","location":{"start":{"value":201,"modifier":"EXACT"},"end":{"value":207,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8ST4"}]},{"type":"Beta strand","location":{"start":{"value":209,"modifier":"EXACT"},"end":{"value":214,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8ST4"}]},{"type":"Turn","location":{"start":{"value":216,"modifier":"EXACT"},"end":{"value":218,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8ST4"}]},{"type":"Beta strand","location":{"start":{"value":222,"modifier":"EXACT"},"end":{"value":232,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8ST4"}]},{"type":"Beta strand","location":{"start":{"value":233,"modifier":"EXACT"},"end":{"value":236,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2K58"}]},{"type":"Helix","location":{"start":{"value":238,"modifier":"EXACT"},"end":{"value":242,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8ST4"}]},{"type":"Helix","location":{"start":{"value":243,"modifier":"EXACT"},"end":{"value":250,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8ST4"}]},{"type":"Helix","location":{"start":{"value":251,"modifier":"EXACT"},"end":{"value":256,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8ST4"}]},{"type":"Helix","location":{"start":{"value":260,"modifier":"EXACT"},"end":{"value":262,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8ST4"}]},{"type":"Helix","location":{"start":{"value":265,"modifier":"EXACT"},"end":{"value":286,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8ST4"}]},{"type":"Helix","location":{"start":{"value":289,"modifier":"EXACT"},"end":{"value":291,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2LM2"}]},{"type":"Helix","location":{"start":{"value":296,"modifier":"EXACT"},"end":{"value":322,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8ST4"}]},{"type":"Turn","location":{"start":{"value":326,"modifier":"EXACT"},"end":{"value":328,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8ST4"}]},{"type":"Helix","location":{"start":{"value":336,"modifier":"EXACT"},"end":{"value":342,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8ST4"}]},{"type":"Helix","location":{"start":{"value":343,"modifier":"EXACT"},"end":{"value":347,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8ST4"}]},{"type":"Helix","location":{"start":{"value":447,"modifier":"EXACT"},"end":{"value":472,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8ST4"}]},{"type":"Helix","location":{"start":{"value":475,"modifier":"EXACT"},"end":{"value":478,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8ST3"}]},{"type":"Turn","location":{"start":{"value":480,"modifier":"EXACT"},"end":{"value":482,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2KSR"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-0225","category":"Disease","name":"Disease variant"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0887","category":"Disease","name":"Epilepsy"},{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-0407","category":"Molecular function","name":"Ion channel"},{"id":"KW-0406","category":"Biological process","name":"Ion transport"},{"id":"KW-1071","category":"Molecular function","name":"Ligand-gated ion channel"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0732","category":"Domain","name":"Signal"},{"id":"KW-0770","category":"Cellular component","name":"Synapse"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"2377478","citationType":"journal article","authors":["Anand R.","Lindstrom J."],"citationCrossReferences":[{"database":"PubMed","id":"2377478"},{"database":"DOI","id":"10.1093/nar/18.14.4272"}],"title":"Nucleotide sequence of the human nicotinic acetylcholine receptor beta 2 subunit gene.","publicationDate":"1990","journal":"Nucleic Acids Res.","firstPage":"4272","lastPage":"4272","volume":"18"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"],"referenceComments":[{"value":"Fetal brain","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"8906617","citationType":"journal article","authors":["Elliott K.J.","Ellis S.B.","Berckhan K.J.","Urrutia A.","Chavez-Noriega L.E.","Johnson E.C.","Velicelebi G.","Harpold M.M."],"citationCrossReferences":[{"database":"PubMed","id":"8906617"},{"database":"DOI","id":"10.1007/bf02736842"}],"title":"Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits.","publicationDate":"1996","journal":"J. Mol. Neurosci.","firstPage":"217","lastPage":"228","volume":"7"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"9009220","citationType":"journal article","authors":["Groot Kormelink P.J.","Luyten W.H.M.L."],"citationCrossReferences":[{"database":"PubMed","id":"9009220"},{"database":"DOI","id":"10.1016/s0014-5793(96)01383-x"}],"title":"Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32.","publicationDate":"1997","journal":"FEBS Lett.","firstPage":"309","lastPage":"314","volume":"400"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"],"referenceComments":[{"value":"Frontal cortex","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"9921897","citationType":"journal article","authors":["Rempel N.","Heyers S.","Engels H.","Sleegers E.","Steinlein O.K."],"citationCrossReferences":[{"database":"PubMed","id":"9921897"},{"database":"DOI","id":"10.1007/s004390050885"}],"title":"The structures of the human neuronal nicotinic acetylcholine receptor beta2- and alpha3-subunit genes (CHRNB2 and CHRNA3).","publicationDate":"1998","journal":"Hum. Genet.","firstPage":"645","lastPage":"653","volume":"103"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":5,"citation":{"id":"10441742","citationType":"journal article","authors":["Lueders K.K.","Elliott R.W.","Marenholz I.","Mischke D.","DuPree M.","Hamer D."],"citationCrossReferences":[{"database":"PubMed","id":"10441742"},{"database":"DOI","id":"10.1007/s003359901111"}],"title":"Genomic organization and mapping of the human and mouse neuronal beta2-nicotinic acetylcholine receptor genes.","publicationDate":"1999","journal":"Mamm. Genome","firstPage":"900","lastPage":"905","volume":"10"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":6,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":7,"citation":{"id":"8663494","citationType":"journal article","authors":["Wang F.","Gerzanich V.","Wells G.B.","Anand R.","Peng X.","Keyser K.","Lindstrom J."],"citationCrossReferences":[{"database":"PubMed","id":"8663494"},{"database":"DOI","id":"10.1074/jbc.271.30.17656"}],"title":"Assembly of human neuronal nicotinic receptor alpha5 subunits with alpha3, beta2, and beta4 subunits.","publicationDate":"1996","journal":"J. Biol. Chem.","firstPage":"17656","lastPage":"17665","volume":"271"},"referencePositions":["FUNCTION","SUBUNIT"]},{"referenceNumber":8,"citation":{"id":"11118490","citationType":"journal article","authors":["Boorman J.P.","Groot-Kormelink P.J.","Sivilotti L.G."],"citationCrossReferences":[{"database":"PubMed","id":"11118490"},{"database":"DOI","id":"10.1111/j.1469-7793.2000.00565.x"}],"title":"Stoichiometry of human recombinant neuronal nicotinic receptors containing the b3 subunit expressed in Xenopus oocytes.","publicationDate":"2000","journal":"J. Physiol. (Lond.)","firstPage":"565","lastPage":"577","volume":"529"},"referencePositions":["FUNCTION","SUBUNIT","STOICHIOMETRY","ACTIVITY REGULATION"]},{"referenceNumber":9,"citation":{"id":"16835356","citationType":"journal article","authors":["Tumkosit P.","Kuryatov A.","Luo J.","Lindstrom J."],"citationCrossReferences":[{"database":"PubMed","id":"16835356"},{"database":"DOI","id":"10.1124/mol.106.027326"}],"title":"Beta3 subunits promote expression and nicotine-induced up-regulation of human nicotinic alpha6* nicotinic acetylcholine receptors expressed in transfected cell lines.","publicationDate":"2006","journal":"Mol. Pharmacol.","firstPage":"1358","lastPage":"1368","volume":"70"},"referencePositions":["FUNCTION","SUBUNIT","ACTIVITY REGULATION"]},{"referenceNumber":10,"citation":{"id":"12527804","citationType":"journal article","authors":["Nelson M.E.","Kuryatov A.","Choi C.H.","Zhou Y.","Lindstrom J."],"citationCrossReferences":[{"database":"PubMed","id":"12527804"},{"database":"DOI","id":"10.1124/mol.63.2.332"}],"title":"Alternate stoichiometries of alpha4beta2 nicotinic acetylcholine receptors.","publicationDate":"2003","journal":"Mol. Pharmacol.","firstPage":"332","lastPage":"341","volume":"63"},"referencePositions":["FUNCTION","SUBUNIT","ACTIVITY REGULATION","STOICHIOMETRY"]},{"referenceNumber":11,"citation":{"id":"15609996","citationType":"journal article","authors":["Ellison M.","Gao F.","Wang H.L.","Sine S.M.","McIntosh J.M.","Olivera B.M."],"citationCrossReferences":[{"database":"PubMed","id":"15609996"},{"database":"DOI","id":"10.1021/bi048918g"}],"title":"Alpha-conotoxins ImI and ImII target distinct regions of the human alpha7 nicotinic acetylcholine receptor and distinguish human nicotinic receptor subtypes.","publicationDate":"2004","journal":"Biochemistry","firstPage":"16019","lastPage":"16026","volume":"43"},"referencePositions":["FUNCTION","SYNTHESIS OF 5-16","3D-STRUCTURE MODELING","ACTIVITY REGULATION"]},{"referenceNumber":12,"citation":{"id":"16120769","citationType":"journal article","authors":["Lansdell S.J.","Gee V.J.","Harkness P.C.","Doward A.I.","Baker E.R.","Gibb A.J.","Millar N.S."],"citationCrossReferences":[{"database":"PubMed","id":"16120769"},{"database":"DOI","id":"10.1124/mol.105.017459"}],"title":"RIC-3 enhances functional expression of multiple nicotinic acetylcholine receptor subtypes in mammalian cells.","publicationDate":"2005","journal":"Mol. Pharmacol.","firstPage":"1431","lastPage":"1438","volume":"68"},"referencePositions":["INTERACTION WITH RIC3"]},{"referenceNumber":13,"citation":{"id":"17132685","citationType":"journal article","authors":["Tapia L.","Kuryatov A.","Lindstrom J."],"citationCrossReferences":[{"database":"PubMed","id":"17132685"},{"database":"DOI","id":"10.1124/mol.106.030445"}],"title":"Ca2+ permeability of the (alpha4)3(beta2)2 stoichiometry greatly exceeds that of (alpha4)2(beta2)3 human acetylcholine receptors.","publicationDate":"2007","journal":"Mol. Pharmacol.","firstPage":"769","lastPage":"776","volume":"71"},"referencePositions":["FUNCTION","SUBUNIT","ACTIVITY REGULATION","STOICHIOMETRY","CATALYTIC ACTIVITY","MUTAGENESIS OF LYS-285"]},{"referenceNumber":14,"citation":{"id":"20881005","citationType":"journal article","authors":["Kuryatov A.","Berrettini W.","Lindstrom J."],"citationCrossReferences":[{"database":"PubMed","id":"20881005"},{"database":"DOI","id":"10.1124/mol.110.066357"}],"title":"Acetylcholine receptor (AChR) alpha5 subunit variant associated with risk for nicotine dependence and lung cancer reduces (alpha4beta2)(2)alpha5 AChR function.","publicationDate":"2011","journal":"Mol. Pharmacol.","firstPage":"119","lastPage":"125","volume":"79"},"referencePositions":["FUNCTION","CATALYTIC ACTIVITY","SUBUNIT","ACTIVITY REGULATION"]},{"referenceNumber":15,"citation":{"id":"27344019","citationType":"journal article","authors":["Arvaniti M.","Jensen M.M.","Soni N.","Wang H.","Klein A.B.","Thiriet N.","Pinborg L.H.","Muldoon P.P.","Wienecke J.","Imad Damaj M.","Kohlmeier K.A.","Gondre-Lewis M.C.","Mikkelsen J.D.","Thomsen M.S."],"citationCrossReferences":[{"database":"PubMed","id":"27344019"},{"database":"DOI","id":"10.1111/jnc.13718"}],"title":"Functional interaction between Lypd6 and nicotinic acetylcholine receptors.","publicationDate":"2016","journal":"J. Neurochem.","firstPage":"806","lastPage":"820","volume":"138"},"referencePositions":["INTERACTION WITH LYPD6"]},{"referenceNumber":16,"citation":{"id":"27493220","citationType":"journal article","authors":["Kouvatsos N.","Giastas P.","Chroni-Tzartou D.","Poulopoulou C.","Tzartos S.J."],"citationCrossReferences":[{"database":"PubMed","id":"27493220"},{"database":"DOI","id":"10.1073/pnas.1602619113"}],"title":"Crystal structure of a human neuronal nAChR extracellular domain in pentameric assembly: Ligand-bound alpha2 homopentamer.","publicationDate":"2016","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"9635","lastPage":"9640","volume":"113"},"referencePositions":["MUTAGENESIS OF PHE-197","SUBUNIT"]},{"referenceNumber":17,"citation":{"id":"33239400","citationType":"journal article","authors":["George A.A.","Vieira J.M.","Xavier-Jackson C.","Gee M.T.","Cirrito J.R.","Bimonte-Nelson H.A.","Picciotto M.R.","Lukas R.J.","Whiteaker P."],"citationCrossReferences":[{"database":"PubMed","id":"33239400"},{"database":"DOI","id":"10.1523/jneurosci.0876-20.2020"}],"title":"Implications of Oligomeric Amyloid-Beta (oAbeta42) Signaling through alpha7beta2-Nicotinic Acetylcholine Receptors (nAChRs) on Basal Forebrain Cholinergic Neuronal Intrinsic Excitability and Cognitive Decline.","publicationDate":"2021","journal":"J. Neurosci.","firstPage":"555","lastPage":"575","volume":"41"},"referencePositions":["FUNCTION","ACTIVITY REGULATION","SUBUNIT"]},{"referenceNumber":18,"citation":{"id":"38161283","citationType":"journal article","authors":["George A.A.","John S.J.","Lucero L.M.","Eaton J.B.","Jaiswal E.","Christensen S.B.","Gajewiak J.","Watkins M.","Cao Y.","Olivera B.M.","Im W.","McIntosh J.M.","Whiteaker P."],"citationCrossReferences":[{"database":"PubMed","id":"38161283"},{"database":"DOI","id":"10.1096/fj.202302079"}],"title":"Analogs of alpha-conotoxin PnIC selectively inhibit alpha7beta2- over alpha7-only subtype nicotinic acetylcholine receptors via a novel allosteric mechanism.","publicationDate":"2024","journal":"FASEB J.","firstPage":"e23374","lastPage":"e23374","volume":"38"},"referencePositions":["FUNCTION","SUBUNIT","ACTIVITY REGULATION"]},{"referenceNumber":19,"citation":{"id":"20441771","citationType":"journal article","authors":["Bondarenko V.","Tillman T.","Xu Y.","Tang P."],"citationCrossReferences":[{"database":"PubMed","id":"20441771"},{"database":"DOI","id":"10.1016/j.bbamem.2010.04.014"}],"title":"NMR structure of the transmembrane domain of the n-acetylcholine receptor beta2 subunit.","publicationDate":"2010","journal":"Biochim. Biophys. Acta","firstPage":"1608","lastPage":"1614","volume":"1798"},"referencePositions":["STRUCTURE BY NMR OF 231-486"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"2KSR"}]},{"referenceNumber":20,"citation":{"id":"22361591","citationType":"journal article","authors":["Bondarenko V.","Mowrey D.","Tillman T.","Cui T.","Liu L.T.","Xu Y.","Tang P."],"citationCrossReferences":[{"database":"PubMed","id":"22361591"},{"database":"DOI","id":"10.1016/j.bbamem.2012.02.008"}],"title":"NMR structures of the transmembrane domains of the alpha4beta2 nAChR.","publicationDate":"2012","journal":"Biochim. Biophys. Acta","firstPage":"1261","lastPage":"1268","volume":"1818"},"referencePositions":["STRUCTURE BY NMR OF 234-484","SUBUNIT","FUNCTION","CATALYTIC ACTIVITY"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"2LM2"}]},{"referenceNumber":21,"citation":{"id":"27698419","citationType":"journal article","authors":["Morales-Perez C.L.","Noviello C.M.","Hibbs R.E."],"citationCrossReferences":[{"database":"PubMed","id":"27698419"},{"database":"DOI","id":"10.1038/nature19785"}],"title":"X-ray structure of the human alpha4beta2 nicotinic receptor.","publicationDate":"2016","journal":"Nature","firstPage":"411","lastPage":"415","volume":"538"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (3.94 ANGSTROMS) OF 26-355 AND 446-502","GLYCOSYLATION AT ASN-168 IN COMPLEX WITH CHRNA4","DISULFIDE BONDS","SUBUNIT"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"5KXI"}]},{"referenceNumber":22,"citation":{"id":"29720657","citationType":"journal article","authors":["Walsh R.M.","Roh S.H.","Gharpure A.","Morales-Perez C.L.","Teng J.","Hibbs R.E."],"citationCrossReferences":[{"database":"PubMed","id":"29720657"},{"database":"DOI","id":"10.1038/s41586-018-0081-7"}],"title":"Structural principles of distinct assemblies of the human alpha4beta2 nicotinic receptor.","publicationDate":"2018","journal":"Nature","firstPage":"261","lastPage":"265","volume":"557"},"referencePositions":["STRUCTURE BY ELECTRON MICROSCOPY (3.40 ANGSTROMS) OF 26-353 AND 446-502 IN COMPLEX WITH CHRNA4","DISULFIDE BONDS","SUBUNIT"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"6CNJ"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6CNK"}]},{"referenceNumber":23,"citation":{"id":"38454578","citationType":"journal article","authors":["Mazzaferro S.","Kang G.","Natarajan K.","Hibbs R.E.","Sine S.M."],"citationCrossReferences":[{"database":"PubMed","id":"38454578"},{"database":"DOI","id":"10.1111/bph.16321"}],"title":"Structural bases for stoichiometry-selective calcium potentiation of a neuronal nicotinic receptor.","publicationDate":"2024","journal":"Br. J. Pharmacol.","firstPage":"1973","lastPage":"1992","volume":"181"},"referencePositions":["STRUCTURE BY ELECTRON MICROSCOPY (2.35 ANGSTROMS) OF 26-502 IN COMPLEX WITH CALCIUM; ACETYLCHOLINE AND CHRNA4","DISULFIDE BONDS","SUBUNIT","CATALYTIC ACTIVITY","ACTIVITY REGULATION","FUNCTION","MUTAGENESIS OF GLU-72; GLU-74; ASP-196; GLU-202 AND ASP-218"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"8SSZ"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8ST0"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8ST1"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8ST2"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8ST3"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8ST4"}]},{"referenceNumber":24,"citation":{"id":"11062464","citationType":"journal article","authors":["De Fusco M.","Becchetti A.","Patrignani A.","Annesi G.","Gambardella A.","Quattrone A.","Ballabio A.","Wanke E.","Casari G."],"citationCrossReferences":[{"database":"PubMed","id":"11062464"},{"database":"DOI","id":"10.1038/81566"}],"title":"The nicotinic receptor beta-2 subunit is mutant in nocturnal frontal lobe epilepsy.","publicationDate":"2000","journal":"Nat. Genet.","firstPage":"275","lastPage":"276","volume":"26"},"referencePositions":["VARIANT ENFL3 LEU-287"]},{"referenceNumber":25,"citation":{"id":"11104662","citationType":"journal article","authors":["Phillips H.A.","Favre I.","Kirkpatrick M.","Zuberi S.M.","Goudie D.","Heron S.E.","Scheffer I.E.","Sutherland G.R.","Berkovic S.F.","Bertrand D.","Mulley J.C."],"citationCrossReferences":[{"database":"PubMed","id":"11104662"},{"database":"DOI","id":"10.1086/316946"}],"title":"CHRNB2 is the second acetylcholine receptor subunit associated with autosomal dominant nocturnal frontal lobe epilepsy.","publicationDate":"2001","journal":"Am. J. Hum. Genet.","firstPage":"225","lastPage":"231","volume":"68"},"referencePositions":["VARIANT ENFL3 MET-287"]},{"referenceNumber":26,"citation":{"id":"11906688","citationType":"journal article","authors":["Lueders K.K.","Hu S.","McHugh L.","Myakishev M.V.","Sirota L.A.","Hamer D.H."],"citationCrossReferences":[{"database":"PubMed","id":"11906688"},{"database":"DOI","id":"10.1080/14622200110098419"}],"title":"Genetic and functional analysis of single nucleotide polymorphisms in the beta2-neuronal nicotinic acetylcholine receptor gene (CHRNB2).","publicationDate":"2002","journal":"Nicotine Tob. Res.","firstPage":"115","lastPage":"125","volume":"4"},"referencePositions":["VARIANT HIS-397"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"X53179","properties":[{"key":"ProteinId","value":"CAA37320.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"U62437","properties":[{"key":"ProteinId","value":"AAB40115.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"Y08415","properties":[{"key":"ProteinId","value":"CAA69692.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AJ001935","properties":[{"key":"ProteinId","value":"CAA05108.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AJ001936","properties":[{"key":"ProteinId","value":"CAA05108.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AJ001937","properties":[{"key":"ProteinId","value":"CAA05108.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AJ001938","properties":[{"key":"ProteinId","value":"CAA05108.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AJ001939","properties":[{"key":"ProteinId","value":"CAA05108.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF077186","properties":[{"key":"ProteinId","value":"AAD45422.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC075040","properties":[{"key":"ProteinId","value":"AAH75040.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC075041","properties":[{"key":"ProteinId","value":"AAH75041.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS1070.1","properties":[{"key":"Description","value":"-"}]},{"database":"PIR","id":"S10505","properties":[{"key":"EntryName","value":"S10505"}]},{"database":"RefSeq","id":"NP_000739.1","properties":[{"key":"NucleotideSequenceId","value":"NM_000748.3"}]},{"database":"PDB","id":"2K58","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"B=231-265"}]},{"database":"PDB","id":"2K59","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"B=264-291"}]},{"database":"PDB","id":"2KSR","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=231-330, A=453-486"}]},{"database":"PDB","id":"2LM2","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=231-330, A=458-485"}]},{"database":"PDB","id":"5KXI","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.94 A"},{"key":"Chains","value":"B/C/E=26-355, B/C/E=446-502"}]},{"database":"PDB","id":"6CNJ","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.40 A"},{"key":"Chains","value":"B/C/E=26-353, B/C/E=446-502"}]},{"database":"PDB","id":"6CNK","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.70 A"},{"key":"Chains","value":"C/E=26-353, C/E=446-502"}]},{"database":"PDB","id":"6UR8","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.71 A"},{"key":"Chains","value":"B/C/E=26-502"}]},{"database":"PDB","id":"6USF","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.87 A"},{"key":"Chains","value":"B/C/E=26-502"}]},{"database":"PDB","id":"8SSZ","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.64 A"},{"key":"Chains","value":"B/C/E=26-502"}]},{"database":"PDB","id":"8ST0","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.40 A"},{"key":"Chains","value":"B/C/E=26-502"}]},{"database":"PDB","id":"8ST1","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.41 A"},{"key":"Chains","value":"C/E=26-502"}]},{"database":"PDB","id":"8ST2","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.94 A"},{"key":"Chains","value":"C/E=26-502"}]},{"database":"PDB","id":"8ST3","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.93 A"},{"key":"Chains","value":"B/C/E=26-502"}]},{"database":"PDB","id":"8ST4","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.35 A"},{"key":"Chains","value":"B/C/E=26-502"}]},{"database":"PDBsum","id":"2K58","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2K59","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2KSR","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2LM2","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5KXI","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6CNJ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6CNK","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6UR8","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6USF","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8SSZ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8ST0","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8ST1","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8ST2","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8ST3","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8ST4","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"P17787","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-20857","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-20863","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40752","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40753","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40754","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40755","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40756","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40757","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-7535","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-7536","properties":[{"key":"Description","value":"-"}]},{"database":"MDRepo","id":"P17787","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P17787","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"107563","properties":[{"key":"Interactions","value":"104"}]},{"database":"ComplexPortal","id":"CPX-168","properties":[{"key":"EntryName","value":"Neuronal nicotinic acetylcholine receptor complex, 3xalpha4-2xbeta2"}]},{"database":"ComplexPortal","id":"CPX-187","properties":[{"key":"EntryName","value":"Neuronal nicotinic acetylcholine receptor complex, alpha3-alpha5-beta2"}]},{"database":"ComplexPortal","id":"CPX-2170","properties":[{"key":"EntryName","value":"Neuronal nicotinic acetylcholine receptor complex, alpha2-beta2"}]},{"database":"ComplexPortal","id":"CPX-218","properties":[{"key":"EntryName","value":"Neuronal nicotinic acetylcholine receptor complex, alpha4-alpha5-beta2"}]},{"database":"ComplexPortal","id":"CPX-2180","properties":[{"key":"EntryName","value":"Neuronal nicotinic acetylcholine receptor complex, 2xalpha4-3xbeta2"}]},{"database":"ComplexPortal","id":"CPX-2192","properties":[{"key":"EntryName","value":"Neuronal nicotinic acetylcholine receptor complex, alpha3-alpha6-beta2-beta3"}]},{"database":"ComplexPortal","id":"CPX-2193","properties":[{"key":"EntryName","value":"Neuronal nicotinic acetylcholine receptor complex, alpha3-beta2"}]},{"database":"ComplexPortal","id":"CPX-240","properties":[{"key":"EntryName","value":"Neuronal nicotinic acetylcholine receptor complex, alpha7-beta2"}]},{"database":"CORUM","id":"P17787","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P17787","properties":[{"key":"Number of interactors","value":"542"}]},{"database":"IntAct","id":"P17787","properties":[{"key":"Interactions","value":"134"}]},{"database":"NDEx","id":"IQUERY-CP-CHRNB2","properties":[{"key":"Evidences","value":"3 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000357461","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"P17787","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL1883","properties":[{"key":"Description","value":"-"}]},{"database":"DrugBank","id":"DB21141","properties":[{"key":"GenericName","value":"Altinicline"}]},{"database":"DrugBank","id":"DB00572","properties":[{"key":"GenericName","value":"Atropine"}]},{"database":"DrugBank","id":"DB05712","properties":[{"key":"GenericName","value":"AZD-9684"}]},{"database":"DrugBank","id":"DB00237","properties":[{"key":"GenericName","value":"Butabarbital"}]},{"database":"DrugBank","id":"DB00565","properties":[{"key":"GenericName","value":"Cisatracurium"}]},{"database":"DrugBank","id":"DB12244","properties":[{"key":"GenericName","value":"CP-601927"}]},{"database":"DrugBank","id":"DB09028","properties":[{"key":"GenericName","value":"Cytisine"}]},{"database":"DrugBank","id":"DB01245","properties":[{"key":"GenericName","value":"Decamethonium"}]},{"database":"DrugBank","id":"DB11807","properties":[{"key":"GenericName","value":"Dexmecamylamine"}]},{"database":"DrugBank","id":"DB00514","properties":[{"key":"GenericName","value":"Dextromethorphan"}]},{"database":"DrugBank","id":"DB12125","properties":[{"key":"GenericName","value":"Dianicline"}]},{"database":"DrugBank","id":"DB07720","properties":[{"key":"GenericName","value":"Epibatidine"}]},{"database":"DrugBank","id":"DB00898","properties":[{"key":"GenericName","value":"Ethanol"}]},{"database":"DrugBank","id":"DB00753","properties":[{"key":"GenericName","value":"Isoflurane"}]},{"database":"DrugBank","id":"DB16205","properties":[{"key":"GenericName","value":"Ispronicline"}]},{"database":"DrugBank","id":"DB00657","properties":[{"key":"GenericName","value":"Mecamylamine"}]},{"database":"DrugBank","id":"DB00333","properties":[{"key":"GenericName","value":"Methadone"}]},{"database":"DrugBank","id":"DB00416","properties":[{"key":"GenericName","value":"Metocurine iodide"}]},{"database":"DrugBank","id":"DB00184","properties":[{"key":"GenericName","value":"Nicotine"}]},{"database":"DrugBank","id":"DB00981","properties":[{"key":"GenericName","value":"Physostigmine"}]},{"database":"DrugBank","id":"DB05458","properties":[{"key":"GenericName","value":"Pozanicline"}]},{"database":"DrugBank","id":"DB05855","properties":[{"key":"GenericName","value":"Rivanicline"}]},{"database":"DrugBank","id":"DB05740","properties":[{"key":"GenericName","value":"RPI-78M"}]},{"database":"DrugBank","id":"DB00747","properties":[{"key":"GenericName","value":"Scopolamine"}]},{"database":"DrugBank","id":"DB12527","properties":[{"key":"GenericName","value":"Sofinicline"}]},{"database":"DrugBank","id":"DB00202","properties":[{"key":"GenericName","value":"Succinylcholine"}]},{"database":"DrugBank","id":"DB06044","properties":[{"key":"GenericName","value":"TC-2216"}]},{"database":"DrugBank","id":"DB20434","properties":[{"key":"GenericName","value":"Tebanicline"}]},{"database":"DrugBank","id":"DB01273","properties":[{"key":"GenericName","value":"Varenicline"}]},{"database":"DrugCentral","id":"P17787","properties":[{"key":"Description","value":"-"}]},{"database":"TCDB","id":"1.A.9.1.6","properties":[{"key":"FamilyName","value":"the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family"}]},{"database":"GlyCosmos","id":"P17787","properties":[{"key":"glycosylation","value":"3 sites, No reported glycans"}]},{"database":"GlyGen","id":"P17787","properties":[{"key":"glycosylation","value":"3 sites, 1 N-linked glycan (1 site)"}]},{"database":"PhosphoSitePlus","id":"P17787","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"CHRNB2","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"113105","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"P17787","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000357461","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P17787","properties":[{"key":"Description","value":"-"}]},{"database":"ABCD","id":"P17787","properties":[{"key":"antibodies","value":"1 sequenced antibody"}]},{"database":"Antibodypedia","id":"20401","properties":[{"key":"antibodies","value":"268 antibodies from 35 providers"}]},{"database":"DNASU","id":"1141","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000368476.4","properties":[{"key":"ProteinId","value":"ENSP00000357461.3"},{"key":"GeneId","value":"ENSG00000160716.6"}]},{"database":"GeneID","id":"1141","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:1141","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000368476.4","properties":[{"key":"ProteinId","value":"ENSP00000357461.3"},{"key":"RefSeqNucleotideId","value":"NM_000748.3"},{"key":"RefSeqProteinId","value":"NP_000739.1"}]},{"database":"AGR","id":"HGNC:1962","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA115","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"1141","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"1141","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"CHRNB2","properties":[{"key":"Description","value":"-"}]},{"database":"GeneReviews","id":"CHRNB2","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:1962","properties":[{"key":"GeneName","value":"CHRNB2"}]},{"database":"HPA","id":"ENSG00000160716","properties":[{"key":"ExpressionPatterns","value":"Group enriched (brain, pituitary gland, retina)"}]},{"database":"MalaCards","id":"CHRNB2","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"118507","properties":[{"key":"Type","value":"gene"}]},{"database":"MIM","id":"605375","properties":[{"key":"Type","value":"phenotype"}]},{"database":"OpenTargets","id":"ENSG00000160716","properties":[{"key":"Description","value":"-"}]},{"database":"Orphanet","id":"98784","properties":[{"key":"Disease","value":"Sleep-related hypermotor epilepsy"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000160716","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG3645","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000158417","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_018074_1_3_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P17787","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"5975154at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"P17787","properties":[{"key":"Number of GO annotations","value":"10 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"P17787","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"P17787","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-629587","properties":[{"key":"PathwayName","value":"Highly sodium permeable postsynaptic acetylcholine nicotinic receptors"}]},{"database":"Reactome","id":"R-HSA-629594","properties":[{"key":"PathwayName","value":"Highly calcium permeable postsynaptic nicotinic acetylcholine receptors"}]},{"database":"Reactome","id":"R-HSA-629597","properties":[{"key":"PathwayName","value":"Highly calcium permeable nicotinic acetylcholine receptors"}]},{"database":"SignaLink","id":"P17787","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"P17787","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000160716","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"1141","properties":[{"key":"hits","value":"13 hits in 1158 CRISPR screens"}]},{"database":"ChiTaRS","id":"CHRNB2","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"P17787","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"CHRNB2","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"1141","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"P17787","properties":[{"key":"DevelopmentLevel","value":"Tclin"}]},{"database":"PRO","id":"PR:P17787","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"RNAct","id":"P17787","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000160716","properties":[{"key":"ExpressionPatterns","value":"Expressed in cervix squamous epithelium and 160 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"P17787","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005892","properties":[{"key":"GoTerm","value":"C:acetylcholine-gated channel complex"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17132685"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"27698419"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"29720657"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"38454578"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"8906617"}]},{"database":"GO","id":"GO:0009897","properties":[{"key":"GoTerm","value":"C:external side of plasma membrane"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"NAS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"8906617"}]},{"database":"GO","id":"GO:0043005","properties":[{"key":"GoTerm","value":"C:neuron projection"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0044853","properties":[{"key":"GoTerm","value":"C:plasma membrane raft"},{"key":"GoEvidenceType","value":"ISS:ARUK-UCL"}]},{"database":"GO","id":"GO:0045211","properties":[{"key":"GoTerm","value":"C:postsynaptic membrane"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0042734","properties":[{"key":"GoTerm","value":"C:presynaptic membrane"},{"key":"GoEvidenceType","value":"TAS:UniProt"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"20881005"}]},{"database":"GO","id":"GO:0045202","properties":[{"key":"GoTerm","value":"C:synapse"},{"key":"GoEvidenceType","value":"IDA:UniProt"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24467848"}]},{"database":"GO","id":"GO:0097060","properties":[{"key":"GoTerm","value":"C:synaptic membrane"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0042166","properties":[{"key":"GoTerm","value":"F:acetylcholine binding"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"15964197"}]},{"database":"GO","id":"GO:0015464","properties":[{"key":"GoTerm","value":"F:acetylcholine receptor activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"8906617"}]},{"database":"GO","id":"GO:0022848","properties":[{"key":"GoTerm","value":"F:acetylcholine-gated monoatomic cation-selective channel activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17132685"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18387948"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"27698419"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"29720657"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"38454578"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"8906617"}]},{"database":"GO","id":"GO:0015276","properties":[{"key":"GoTerm","value":"F:ligand-gated monoatomic ion channel activity"},{"key":"GoEvidenceType","value":"TAS:DFLAT"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"20438829"}]},{"database":"GO","id":"GO:0095500","properties":[{"key":"GoTerm","value":"P:acetylcholine receptor signaling pathway"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17132685"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"27698419"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"29720657"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"38454578"}]},{"database":"GO","id":"GO:0008306","properties":[{"key":"GoTerm","value":"P:associative learning"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0042113","properties":[{"key":"GoTerm","value":"P:B cell activation"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0035095","properties":[{"key":"GoTerm","value":"P:behavioral response to nicotine"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"17559419"}]},{"database":"GO","id":"GO:0006816","properties":[{"key":"GoTerm","value":"P:calcium ion transport"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0021952","properties":[{"key":"GoTerm","value":"P:central nervous system projection neuron axonogenesis"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0050890","properties":[{"key":"GoTerm","value":"P:cognition"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"17559419"}]},{"database":"GO","id":"GO:0021771","properties":[{"key":"GoTerm","value":"P:lateral geniculate nucleus development"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0007612","properties":[{"key":"GoTerm","value":"P:learning"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"15964197"}]},{"database":"GO","id":"GO:0007626","properties":[{"key":"GoTerm","value":"P:locomotory behavior"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0051899","properties":[{"key":"GoTerm","value":"P:membrane depolarization"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0007613","properties":[{"key":"GoTerm","value":"P:memory"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"15964197"}]},{"database":"GO","id":"GO:0034220","properties":[{"key":"GoTerm","value":"P:monoatomic ion transmembrane transport"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0006811","properties":[{"key":"GoTerm","value":"P:monoatomic ion transport"},{"key":"GoEvidenceType","value":"NAS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"8906617"}]},{"database":"GO","id":"GO:0045759","properties":[{"key":"GoTerm","value":"P:negative regulation of action potential"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0050877","properties":[{"key":"GoTerm","value":"P:nervous system process"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"17900292"}]},{"database":"GO","id":"GO:0021631","properties":[{"key":"GoTerm","value":"P:optic nerve morphogenesis"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0030890","properties":[{"key":"GoTerm","value":"P:positive regulation of B cell proliferation"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0033603","properties":[{"key":"GoTerm","value":"P:positive regulation of dopamine secretion"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0042320","properties":[{"key":"GoTerm","value":"P:regulation of circadian sleep/wake cycle, REM sleep"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0048814","properties":[{"key":"GoTerm","value":"P:regulation of dendrite morphogenesis"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0042053","properties":[{"key":"GoTerm","value":"P:regulation of dopamine metabolic process"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0014059","properties":[{"key":"GoTerm","value":"P:regulation of dopamine secretion"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0051963","properties":[{"key":"GoTerm","value":"P:regulation of synapse assembly"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0032225","properties":[{"key":"GoTerm","value":"P:regulation of synaptic transmission, dopaminergic"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:1905144","properties":[{"key":"GoTerm","value":"P:response to acetylcholine"},{"key":"GoEvidenceType","value":"ISS:ARUK-UCL"}]},{"database":"GO","id":"GO:0042220","properties":[{"key":"GoTerm","value":"P:response to cocaine"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0045471","properties":[{"key":"GoTerm","value":"P:response to ethanol"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0001666","properties":[{"key":"GoTerm","value":"P:response to hypoxia"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12189247"}]},{"database":"GO","id":"GO:0035094","properties":[{"key":"GoTerm","value":"P:response to nicotine"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12189247"}]},{"database":"GO","id":"GO:0019233","properties":[{"key":"GoTerm","value":"P:sensory perception of pain"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0007605","properties":[{"key":"GoTerm","value":"P:sensory perception of sound"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0007165","properties":[{"key":"GoTerm","value":"P:signal transduction"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"8906617"}]},{"database":"GO","id":"GO:0006939","properties":[{"key":"GoTerm","value":"P:smooth muscle contraction"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0035176","properties":[{"key":"GoTerm","value":"P:social behavior"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0060084","properties":[{"key":"GoTerm","value":"P:synaptic transmission involved in micturition"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0007271","properties":[{"key":"GoTerm","value":"P:synaptic transmission, cholinergic"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17132685"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"27698419"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"29720657"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"38454578"}]},{"database":"GO","id":"GO:0021562","properties":[{"key":"GoTerm","value":"P:vestibulocochlear nerve development"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0008542","properties":[{"key":"GoTerm","value":"P:visual learning"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"15964197"}]},{"database":"GO","id":"GO:0007601","properties":[{"key":"GoTerm","value":"P:visual perception"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"CDD","id":"cd19025","properties":[{"key":"EntryName","value":"LGIC_ECD_nAChR_B2"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd19064","properties":[{"key":"EntryName","value":"LGIC_TM_nAChR"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.390:FF:000028","properties":[{"key":"EntryName","value":"Cholinergic receptor nicotinic beta 2 subunit"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.70.170.10:FF:000006","properties":[{"key":"EntryName","value":"Cholinergic receptor nicotinic beta 2 subunit"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.390:FF:000008","properties":[{"key":"EntryName","value":"Cholinergic receptor nicotinic beta 4 subunit"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.70.170.10","properties":[{"key":"EntryName","value":"Neurotransmitter-gated ion-channel ligand-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.58.390","properties":[{"key":"EntryName","value":"Neurotransmitter-gated ion-channel transmembrane domain"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR006202","properties":[{"key":"EntryName","value":"Neur_chan_lig-bd"}]},{"database":"InterPro","id":"IPR036734","properties":[{"key":"EntryName","value":"Neur_chan_lig-bd_sf"}]},{"database":"InterPro","id":"IPR006201","properties":[{"key":"EntryName","value":"Neur_channel"}]},{"database":"InterPro","id":"IPR036719","properties":[{"key":"EntryName","value":"Neuro-gated_channel_TM_sf"}]},{"database":"InterPro","id":"IPR038050","properties":[{"key":"EntryName","value":"Neuro_actylchol_rec"}]},{"database":"InterPro","id":"IPR006029","properties":[{"key":"EntryName","value":"Neurotrans-gated_channel_TM"}]},{"database":"InterPro","id":"IPR018000","properties":[{"key":"EntryName","value":"Neurotransmitter_ion_chnl_CS"}]},{"database":"InterPro","id":"IPR002394","properties":[{"key":"EntryName","value":"Nicotinic_acetylcholine_rcpt"}]},{"database":"NCBIfam","id":"TIGR00860","properties":[{"key":"EntryName","value":"LIC"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR18945","properties":[{"key":"EntryName","value":"NEUROTRANSMITTER GATED ION CHANNEL"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02931","properties":[{"key":"EntryName","value":"Neur_chan_LBD"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02932","properties":[{"key":"EntryName","value":"Neur_chan_memb"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00254","properties":[{"key":"EntryName","value":"NICOTINICR"}]},{"database":"PRINTS","id":"PR00252","properties":[{"key":"EntryName","value":"NRIONCHANNEL"}]},{"database":"SUPFAM","id":"SSF90112","properties":[{"key":"EntryName","value":"Neurotransmitter-gated ion-channel transmembrane pore"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF63712","properties":[{"key":"EntryName","value":"Nicotinic receptor ligand binding domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00236","properties":[{"key":"EntryName","value":"NEUROTR_ION_CHANNEL"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MARRCGPVALLLGFGLLRLCSGVWGTDTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLAQLISVHEREQIMTTNVWLTQEWEDYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVLKSEVASLDDFTPSGEWDIVALPGRRNENPDDSTYVDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPALLFMQQPRHHCARQRLRLRRRQREREGAGALFFREAPGADSCTCFVNRASVQGLAGAFGAEPAPVAGPGRSGEPCGCGLREAVDGVRFIADHMRSEDDDQSVSEDWKYVAMVIDRLFLWIFVFVCVFGTIGMFLQPLFQNYTTTTFLHSDHSAPSSK","length":502,"molWeight":57019,"crc64":"7EEDEF6ADFDC9F23","md5":"9E05D4AE9454AA09D9DDC2062488C2EF"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":3,"ACTIVITY REGULATION":1,"SUBUNIT":1,"INTERACTION":2,"SUBCELLULAR LOCATION":1,"DISEASE":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1,"Topological domain":4,"Transmembrane":4,"Site":3,"Glycosylation":3,"Disulfide bond":1,"Natural variant":3,"Mutagenesis":7,"Sequence conflict":3,"Helix":16,"Turn":7,"Beta strand":15},"uniParcId":"UPI000012526E"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q5SXY3","uniProtkbId":"Q5SXY3_HUMAN","entryAudit":{"firstPublicDate":"2005-05-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2005-05-10","entryVersion":169,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAG36255.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00070359"}],"value":"Neuronal acetylcholine receptor subunit beta-2"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"EAW53192.1"}],"value":"CHRNB2"},"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"EAW53192.1"}],"value":"hCG_18732"}]}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"Ca(2+)(in) = Ca(2+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29671"},{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00036634"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"K(+)(in) = K(+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29463"},{"database":"ChEBI","id":"CHEBI:29103"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00034430"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"Na(+)(in) = Na(+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:34963"},{"database":"ChEBI","id":"CHEBI:29101"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00036239"}]}},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00034099"}],"value":"Synaptic cell membrane","id":"SL-0531"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00034099"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00061611"}],"value":"Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta-2/CHRNB2 sub-subfamily"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":25,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000687"}]},{"type":"Chain","location":{"start":{"value":26,"modifier":"EXACT"},"end":{"value":502,"modifier":"EXACT"}},"description":"Neuronal acetylcholine receptor subunit beta-2","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000687"}],"featureId":"PRO_5014309962"},{"type":"Transmembrane","location":{"start":{"value":235,"modifier":"EXACT"},"end":{"value":256,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000687"}]},{"type":"Transmembrane","location":{"start":{"value":268,"modifier":"EXACT"},"end":{"value":288,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000687"}]},{"type":"Transmembrane","location":{"start":{"value":300,"modifier":"EXACT"},"end":{"value":321,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000687"}]},{"type":"Transmembrane","location":{"start":{"value":461,"modifier":"EXACT"},"end":{"value":483,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000687"}]},{"type":"Domain","location":{"start":{"value":29,"modifier":"EXACT"},"end":{"value":234,"modifier":"EXACT"}},"description":"Neurotransmitter-gated ion-channel ligand-binding","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF02931"}]},{"type":"Domain","location":{"start":{"value":241,"modifier":"EXACT"},"end":{"value":478,"modifier":"EXACT"}},"description":"Neurotransmitter-gated ion-channel transmembrane","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF02932"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023303"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000687"}],"id":"KW-0407","category":"Molecular function","name":"Ion channel"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023065"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000687"}],"id":"KW-0406","category":"Biological process","name":"Ion transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023286"}],"id":"KW-1071","category":"Molecular function","name":"Ligand-gated ion channel"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000687"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023170"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAG36255.1"}],"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000687"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023018"}],"id":"KW-0770","category":"Cellular component","name":"Synapse"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000687"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000687"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000687"}],"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"11181995","citationType":"journal article","authors":["Venter J.C.","Adams M.D.","Myers E.W.","Li P.W.","Mural R.J.","Sutton G.G.","Smith H.O.","Yandell M.","Evans C.A.","Holt R.A.","Gocayne J.D.","Amanatides P.","Ballew R.M.","Huson D.H.","Wortman J.R.","Zhang Q.","Kodira C.D.","Zheng X.H.","Chen L.","Skupski M.","Subramanian G.","Thomas P.D.","Zhang J.","Gabor Miklos G.L.","Nelson C.","Broder S.","Clark A.G.","Nadeau J.","McKusick V.A.","Zinder N.","Levine A.J.","Roberts R.J.","Simon M.","Slayman C.","Hunkapiller M.","Bolanos R.","Delcher A.","Dew I.","Fasulo D.","Flanigan M.","Florea L.","Halpern A.","Hannenhalli S.","Kravitz S.","Levy S.","Mobarry C.","Reinert K.","Remington K.","Abu-Threideh J.","Beasley E.","Biddick K.","Bonazzi V.","Brandon R.","Cargill M.","Chandramouliswaran I.","Charlab R.","Chaturvedi K.","Deng Z.","Di Francesco V.","Dunn P.","Eilbeck K.","Evangelista C.","Gabrielian A.E.","Gan W.","Ge W.","Gong F.","Gu Z.","Guan P.","Heiman T.J.","Higgins M.E.","Ji R.R.","Ke Z.","Ketchum K.A.","Lai Z.","Lei Y.","Li Z.","Li J.","Liang Y.","Lin X.","Lu F.","Merkulov G.V.","Milshina N.","Moore H.M.","Naik A.K.","Narayan V.A.","Neelam B.","Nusskern D.","Rusch D.B.","Salzberg S.","Shao W.","Shue B.","Sun J.","Wang Z.","Wang A.","Wang X.","Wang J.","Wei M.","Wides R.","Xiao C.","Yan C.","Yao A.","Ye J.","Zhan M.","Zhang W.","Zhang H.","Zhao Q.","Zheng L.","Zhong F.","Zhong W.","Zhu S.","Zhao S.","Gilbert D.","Baumhueter S.","Spier G.","Carter C.","Cravchik A.","Woodage T.","Ali F.","An H.","Awe A.","Baldwin D.","Baden H.","Barnstead M.","Barrow I.","Beeson K.","Busam D.","Carver A.","Center A.","Cheng M.L.","Curry L.","Danaher S.","Davenport L.","Desilets R.","Dietz S.","Dodson K.","Doup L.","Ferriera S.","Garg N.","Gluecksmann A.","Hart B.","Haynes J.","Haynes C.","Heiner C.","Hladun S.","Hostin D.","Houck J.","Howland T.","Ibegwam C.","Johnson J.","Kalush F.","Kline L.","Koduru S.","Love A.","Mann F.","May D.","McCawley S.","McIntosh T.","McMullen I.","Moy M.","Moy L.","Murphy B.","Nelson K.","Pfannkoch C.","Pratts E.","Puri V.","Qureshi H.","Reardon M.","Rodriguez R.","Rogers Y.H.","Romblad D.","Ruhfel B.","Scott R.","Sitter C.","Smallwood M.","Stewart E.","Strong R.","Suh E.","Thomas R.","Tint N.N.","Tse S.","Vech C.","Wang G.","Wetter J.","Williams S.","Williams M.","Windsor S.","Winn-Deen E.","Wolfe K.","Zaveri J.","Zaveri K.","Abril J.F.","Guigo R.","Campbell M.J.","Sjolander K.V.","Karlak B.","Kejariwal A.","Mi H.","Lazareva B.","Hatton T.","Narechania A.","Diemer K.","Muruganujan A.","Guo N.","Sato S.","Bafna V.","Istrail S.","Lippert R.","Schwartz R.","Walenz B.","Yooseph S.","Allen D.","Basu A.","Baxendale J.","Blick L.","Caminha M.","Carnes-Stine J.","Caulk P.","Chiang Y.H.","Coyne M.","Dahlke C.","Mays A.","Dombroski M.","Donnelly M.","Ely D.","Esparham S.","Fosler C.","Gire H.","Glanowski S.","Glasser K.","Glodek A.","Gorokhov M.","Graham K.","Gropman B.","Harris M.","Heil J.","Henderson S.","Hoover J.","Jennings D.","Jordan C.","Jordan J.","Kasha J.","Kagan L.","Kraft C.","Levitsky A.","Lewis M.","Liu X.","Lopez J.","Ma D.","Majoros W.","McDaniel J.","Murphy S.","Newman M.","Nguyen T.","Nguyen N.","Nodell M.","Pan S.","Peck J.","Peterson M.","Rowe W.","Sanders R.","Scott J.","Simpson M.","Smith T.","Sprague A.","Stockwell T.","Turner R.","Venter E.","Wang M.","Wen M.","Wu D.","Wu M.","Xia A.","Zandieh A.","Zhu X."],"citationCrossReferences":[{"database":"PubMed","id":"11181995"},{"database":"DOI","id":"10.1126/science.1058040"}],"title":"The sequence of the human genome.","publicationDate":"2001","journal":"Science","firstPage":"1304","lastPage":"1351","volume":"291"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"EAW53192.1"}]},{"referenceNumber":2,"citation":{"id":"CI-56FTJV1JKRRTT","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"SEP-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"EAW53192.1"}]},{"referenceNumber":3,"citation":{"id":"CI-6MEA4GF1I55C2","citationType":"submission","authors":["Wakamatsu A.","Yamamoto J.","Kimura K.","Kaida T.","Tsuchiya K.","Iida Y.","Takayama Y.","Murakawa K.","Kanehori K.","Andoh T.","Kagawa N.","Sato R.","Kawamura Y.","Tanaka S.","Kisu Y.","Sugano S.","Goshima N.","Nomura N.","Isogai T."],"title":"NEDO functional analysis of protein and research application project.","publicationDate":"JAN-2008","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAG36255.1"}],"value":"Hippocampus","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAG36255.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AK313470","properties":[{"key":"ProteinId","value":"BAG36255.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"CH471121","properties":[{"key":"ProteinId","value":"EAW53192.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"NP_000739.1","properties":[{"key":"NucleotideSequenceId","value":"NM_000748.3"}]},{"database":"AlphaFoldDB","id":"Q5SXY3","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q5SXY3","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"Q5SXY3","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"20401","properties":[{"key":"antibodies","value":"268 antibodies from 35 providers"}]},{"database":"DNASU","id":"1141","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"1141","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:1141","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc001ffg.4","properties":[{"key":"OrganismName","value":"human"}]},{"database":"ClinPGx","id":"PA115","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"1141","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"1141","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000160716","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_018074_1_3_1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"5975154at2759","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"1141","properties":[{"key":"hits","value":"13 hits in 1158 CRISPR screens"}]},{"database":"ChiTaRS","id":"CHRNB2","properties":[{"key":"OrganismName","value":"human"}]},{"database":"ExpressionAtlas","id":"Q5SXY3","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005892","properties":[{"key":"GoTerm","value":"C:acetylcholine-gated channel complex"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0045211","properties":[{"key":"GoTerm","value":"C:postsynaptic membrane"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0015464","properties":[{"key":"GoTerm","value":"F:acetylcholine receptor activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0022848","properties":[{"key":"GoTerm","value":"F:acetylcholine-gated monoatomic cation-selective channel activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0095500","properties":[{"key":"GoTerm","value":"P:acetylcholine receptor signaling pathway"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0035094","properties":[{"key":"GoTerm","value":"P:response to nicotine"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd19025","properties":[{"key":"EntryName","value":"LGIC_ECD_nAChR_B2"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd19064","properties":[{"key":"EntryName","value":"LGIC_TM_nAChR"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.390:FF:000028","properties":[{"key":"EntryName","value":"Cholinergic receptor nicotinic beta 2 subunit"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.70.170.10:FF:000006","properties":[{"key":"EntryName","value":"Cholinergic receptor nicotinic beta 2 subunit"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.390:FF:000008","properties":[{"key":"EntryName","value":"Cholinergic receptor nicotinic beta 4 subunit"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.70.170.10","properties":[{"key":"EntryName","value":"Neurotransmitter-gated ion-channel ligand-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.58.390","properties":[{"key":"EntryName","value":"Neurotransmitter-gated ion-channel transmembrane domain"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR006202","properties":[{"key":"EntryName","value":"Neur_chan_lig-bd"}]},{"database":"InterPro","id":"IPR036734","properties":[{"key":"EntryName","value":"Neur_chan_lig-bd_sf"}]},{"database":"InterPro","id":"IPR006201","properties":[{"key":"EntryName","value":"Neur_channel"}]},{"database":"InterPro","id":"IPR036719","properties":[{"key":"EntryName","value":"Neuro-gated_channel_TM_sf"}]},{"database":"InterPro","id":"IPR038050","properties":[{"key":"EntryName","value":"Neuro_actylchol_rec"}]},{"database":"InterPro","id":"IPR006029","properties":[{"key":"EntryName","value":"Neurotrans-gated_channel_TM"}]},{"database":"InterPro","id":"IPR018000","properties":[{"key":"EntryName","value":"Neurotransmitter_ion_chnl_CS"}]},{"database":"InterPro","id":"IPR002394","properties":[{"key":"EntryName","value":"Nicotinic_acetylcholine_rcpt"}]},{"database":"NCBIfam","id":"TIGR00860","properties":[{"key":"EntryName","value":"LIC"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR18945","properties":[{"key":"EntryName","value":"NEUROTRANSMITTER GATED ION CHANNEL"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02931","properties":[{"key":"EntryName","value":"Neur_chan_LBD"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02932","properties":[{"key":"EntryName","value":"Neur_chan_memb"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00254","properties":[{"key":"EntryName","value":"NICOTINICR"}]},{"database":"PRINTS","id":"PR00252","properties":[{"key":"EntryName","value":"NRIONCHANNEL"}]},{"database":"SUPFAM","id":"SSF90112","properties":[{"key":"EntryName","value":"Neurotransmitter-gated ion-channel transmembrane pore"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF63712","properties":[{"key":"EntryName","value":"Nicotinic receptor ligand binding domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00236","properties":[{"key":"EntryName","value":"NEUROTR_ION_CHANNEL"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MARRCGPVALLLGFGLLRLCSGVWGTDTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLAQLISVHEREQIMTTNVWLTQEWEDYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVLKSEVASLDDFTPSGEWDIVALPGRRNENPDDSTYVDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPALLFMQQPRHHCARQRLRLRRRQREREGAGALFFREAPGADSCTCFVNRASVQGLAGAFGAEPAPVAGPGRSGEPCGCGLREAVDGVRFIADHMRSEDDDQSVSEDWKYVAMVIDRLFLWIFVFVCVFGTIGMFLQPLFQNYTTTTFLHSDHSAPSSK","length":502,"molWeight":57019,"crc64":"7EEDEF6ADFDC9F23","md5":"9E05D4AE9454AA09D9DDC2062488C2EF"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":3,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1,"Transmembrane":4,"Domain":2},"uniParcId":"UPI000012526E"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A1B0GTH5","uniProtkbId":"A0A1B0GTH5_HUMAN","entryAudit":{"firstPublicDate":"2016-10-05","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2016-10-05","entryVersion":46,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000489703.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00070359"}],"value":"Neuronal acetylcholine receptor subunit beta-2"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000489703.1"}],"value":"CHRNB2"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"Ca(2+)(in) = Ca(2+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29671"},{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00036634"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"K(+)(in) = K(+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29463"},{"database":"ChEBI","id":"CHEBI:29103"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00034430"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"Na(+)(in) = Na(+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:34963"},{"database":"ChEBI","id":"CHEBI:29101"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00036239"}]}},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00034099"}],"value":"Synaptic cell membrane","id":"SL-0531"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00034099"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00061611"}],"value":"Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta-2/CHRNB2 sub-subfamily"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":25,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000687"}]},{"type":"Chain","location":{"start":{"value":26,"modifier":"EXACT"},"end":{"value":518,"modifier":"EXACT"}},"description":"Neuronal acetylcholine receptor subunit beta-2","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000687"}],"featureId":"PRO_5022264483"},{"type":"Transmembrane","location":{"start":{"value":235,"modifier":"EXACT"},"end":{"value":256,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000687"}]},{"type":"Transmembrane","location":{"start":{"value":268,"modifier":"EXACT"},"end":{"value":288,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000687"}]},{"type":"Transmembrane","location":{"start":{"value":300,"modifier":"EXACT"},"end":{"value":321,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000687"}]},{"type":"Transmembrane","location":{"start":{"value":461,"modifier":"EXACT"},"end":{"value":483,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000687"}]},{"type":"Domain","location":{"start":{"value":29,"modifier":"EXACT"},"end":{"value":234,"modifier":"EXACT"}},"description":"Neurotransmitter-gated ion-channel ligand-binding","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF02931"}]},{"type":"Domain","location":{"start":{"value":241,"modifier":"EXACT"},"end":{"value":478,"modifier":"EXACT"}},"description":"Neurotransmitter-gated ion-channel transmembrane","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF02932"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023303"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000687"}],"id":"KW-0407","category":"Molecular function","name":"Ion channel"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023065"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000687"}],"id":"KW-0406","category":"Biological process","name":"Ion transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023286"}],"id":"KW-1071","category":"Molecular function","name":"Ligand-gated ion channel"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000687"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0A1B0GTH5"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023170"}],"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000687"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023018"}],"id":"KW-0770","category":"Cellular component","name":"Synapse"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000687"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000687"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000687"}],"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000489703.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000489703.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16710414","citationType":"journal article","authors":["Gregory S.G.","Barlow K.F.","McLay K.E.","Kaul R.","Swarbreck D.","Dunham A.","Scott C.E.","Howe K.L.","Woodfine K.","Spencer C.C.","Jones M.C.","Gillson C.","Searle S.","Zhou Y.","Kokocinski F.","McDonald L.","Evans R.","Phillips K.","Atkinson A.","Cooper R.","Jones C.","Hall R.E.","Andrews T.D.","Lloyd C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Anderson F.","Andrew R.W.","Ashwell R.I.","Aubin K.","Babbage A.K.","Bagguley C.L.","Bailey J.","Beasley H.","Bethel G.","Bird C.P.","Bray-Allen S.","Brown J.Y.","Brown A.J.","Buckley D.","Burton J.","Bye J.","Carder C.","Chapman J.C.","Clark S.Y.","Clarke G.","Clee C.","Cobley V.","Collier R.E.","Corby N.","Coville G.J.","Davies J.","Deadman R.","Dunn M.","Earthrowl M.","Ellington A.G.","Errington H.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Gay L.","Ghori M.R.","Gibson R.","Gilby L.M.","Gillett W.","Glithero R.J.","Grafham D.V.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Hammond S.","Harrison E.S.","Hart E.","Haugen E.","Heath P.D.","Holmes S.","Holt K.","Howden P.J.","Hunt A.R.","Hunt S.E.","Hunter G.","Isherwood J.","James R.","Johnson C.","Johnson D.","Joy A.","Kay M.","Kershaw J.K.","Kibukawa M.","Kimberley A.M.","King A.","Knights A.J.","Lad H.","Laird G.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Loveland J.","Lovell J.","Lush M.J.","Lyne R.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","Matthews N.S.","McLaren S.","Milne S.","Mistry S.","Moore M.J.","Nickerson T.","O'Dell C.N.","Oliver K.","Palmeiri A.","Palmer S.A.","Parker A.","Patel D.","Pearce A.V.","Peck A.I.","Pelan S.","Phelps K.","Phillimore B.J.","Plumb R.","Rajan J.","Raymond C.","Rouse G.","Saenphimmachak C.","Sehra H.K.","Sheridan E.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.","Steward C.","Subramanian S.","Sycamore N.","Tracey A.","Tromans A.","Van Helmond Z.","Wall M.","Wallis J.M.","White S.","Whitehead S.L.","Wilkinson J.E.","Willey D.L.","Williams H.","Wilming L.","Wray P.W.","Wu Z.","Coulson A.","Vaudin M.","Sulston J.E.","Durbin R.","Hubbard T.","Wooster R.","Dunham I.","Carter N.P.","McVean G.","Ross M.T.","Harrow J.","Olson M.V.","Beck S.","Rogers J.","Bentley D.R.","Banerjee R.","Bryant S.P.","Burford D.C.","Burrill W.D.","Clegg S.M.","Dhami P.","Dovey O.","Faulkner L.M.","Gribble S.M.","Langford C.F.","Pandian R.D.","Porter K.M.","Prigmore E."],"citationCrossReferences":[{"database":"PubMed","id":"16710414"},{"database":"DOI","id":"10.1038/nature04727"}],"title":"The DNA sequence and biological annotation of human chromosome 1.","publicationDate":"2006","journal":"Nature","firstPage":"315","lastPage":"321","volume":"441"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000489703.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000489703.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL592078","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A1B0GTH5","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0A1B0GTH5","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"A0A1B0GTH5","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000636034.1","properties":[{"key":"ProteinId","value":"ENSP00000489703.1"},{"key":"GeneId","value":"ENSG00000160716.6"}]},{"database":"HGNC","id":"HGNC:1962","properties":[{"key":"GeneName","value":"CHRNB2"}]},{"database":"OpenTargets","id":"ENSG00000160716","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000160716","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000158417","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"5975154at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"CHRNB2","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"Bgee","id":"ENSG00000160716","properties":[{"key":"ExpressionPatterns","value":"Expressed in cervix squamous epithelium and 160 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"A0A1B0GTH5","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005892","properties":[{"key":"GoTerm","value":"C:acetylcholine-gated channel complex"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0045211","properties":[{"key":"GoTerm","value":"C:postsynaptic membrane"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0015464","properties":[{"key":"GoTerm","value":"F:acetylcholine receptor activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0022848","properties":[{"key":"GoTerm","value":"F:acetylcholine-gated monoatomic cation-selective channel activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0095500","properties":[{"key":"GoTerm","value":"P:acetylcholine receptor signaling pathway"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0035094","properties":[{"key":"GoTerm","value":"P:response to nicotine"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd19025","properties":[{"key":"EntryName","value":"LGIC_ECD_nAChR_B2"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd19064","properties":[{"key":"EntryName","value":"LGIC_TM_nAChR"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.390:FF:000028","properties":[{"key":"EntryName","value":"Cholinergic receptor nicotinic beta 2 subunit"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.70.170.10:FF:000006","properties":[{"key":"EntryName","value":"Cholinergic receptor nicotinic beta 2 subunit"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.390:FF:000008","properties":[{"key":"EntryName","value":"Cholinergic receptor nicotinic beta 4 subunit"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.70.170.10","properties":[{"key":"EntryName","value":"Neurotransmitter-gated ion-channel ligand-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.58.390","properties":[{"key":"EntryName","value":"Neurotransmitter-gated ion-channel transmembrane domain"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR006202","properties":[{"key":"EntryName","value":"Neur_chan_lig-bd"}]},{"database":"InterPro","id":"IPR036734","properties":[{"key":"EntryName","value":"Neur_chan_lig-bd_sf"}]},{"database":"InterPro","id":"IPR006201","properties":[{"key":"EntryName","value":"Neur_channel"}]},{"database":"InterPro","id":"IPR036719","properties":[{"key":"EntryName","value":"Neuro-gated_channel_TM_sf"}]},{"database":"InterPro","id":"IPR038050","properties":[{"key":"EntryName","value":"Neuro_actylchol_rec"}]},{"database":"InterPro","id":"IPR006029","properties":[{"key":"EntryName","value":"Neurotrans-gated_channel_TM"}]},{"database":"InterPro","id":"IPR018000","properties":[{"key":"EntryName","value":"Neurotransmitter_ion_chnl_CS"}]},{"database":"InterPro","id":"IPR002394","properties":[{"key":"EntryName","value":"Nicotinic_acetylcholine_rcpt"}]},{"database":"NCBIfam","id":"TIGR00860","properties":[{"key":"EntryName","value":"LIC"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR18945","properties":[{"key":"EntryName","value":"NEUROTRANSMITTER GATED ION CHANNEL"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02931","properties":[{"key":"EntryName","value":"Neur_chan_LBD"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02932","properties":[{"key":"EntryName","value":"Neur_chan_memb"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00254","properties":[{"key":"EntryName","value":"NICOTINICR"}]},{"database":"PRINTS","id":"PR00252","properties":[{"key":"EntryName","value":"NRIONCHANNEL"}]},{"database":"SUPFAM","id":"SSF90112","properties":[{"key":"EntryName","value":"Neurotransmitter-gated ion-channel transmembrane pore"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF63712","properties":[{"key":"EntryName","value":"Nicotinic receptor ligand binding domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00236","properties":[{"key":"EntryName","value":"NEUROTR_ION_CHANNEL"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MARRCGPVALLLGFGLLRLCSGVWGTDTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLAQLISVHEREQIMTTNVWLTQEWEDYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVLKSEVASLDDFTPSGEWDIVALPGRRNENPDDSTYVDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPALLFMQQPRHHCARQRLRLRRRQREREGAGALFFREAPGADSCTCFVNRASVQGLAGAFGAEPAPVAGPGRSGEPCGCGLREAVDGVRFIADHMRSEDDDQSVSEDWKYVAMVIDRLFLWIFVFVCVFGTIGMFLQPLFQNYTTTTFLHSDHSAPSSKLKVWGARLSIRGASEF","length":518,"molWeight":58791,"crc64":"E1F3010DA966C0B4","md5":"7CCD27A717AD74ED049D0524B3EE75A1"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":3,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1,"Transmembrane":4,"Domain":2},"uniParcId":"UPI0007E52B8E"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A1B0GVD7","uniProtkbId":"A0A1B0GVD7_HUMAN","entryAudit":{"firstPublicDate":"2016-10-05","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2016-10-05","entryVersion":48,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000490474.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00070359"}],"value":"Neuronal acetylcholine receptor subunit beta-2"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000490474.1"}],"value":"CHRNB2"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"Ca(2+)(in) = Ca(2+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29671"},{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00036634"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"K(+)(in) = K(+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29463"},{"database":"ChEBI","id":"CHEBI:29103"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00034430"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"Na(+)(in) = Na(+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:34963"},{"database":"ChEBI","id":"CHEBI:29101"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00036239"}]}},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00034099"}],"value":"Synaptic cell membrane","id":"SL-0531"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00034099"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00061611"}],"value":"Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta-2/CHRNB2 sub-subfamily"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":25,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000687"}]},{"type":"Chain","location":{"start":{"value":26,"modifier":"EXACT"},"end":{"value":504,"modifier":"EXACT"}},"description":"Neuronal acetylcholine receptor subunit beta-2","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000687"}],"featureId":"PRO_5022261513"},{"type":"Transmembrane","location":{"start":{"value":237,"modifier":"EXACT"},"end":{"value":258,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000687"}]},{"type":"Transmembrane","location":{"start":{"value":270,"modifier":"EXACT"},"end":{"value":290,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000687"}]},{"type":"Transmembrane","location":{"start":{"value":302,"modifier":"EXACT"},"end":{"value":323,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000687"}]},{"type":"Transmembrane","location":{"start":{"value":463,"modifier":"EXACT"},"end":{"value":485,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000687"}]},{"type":"Domain","location":{"start":{"value":29,"modifier":"EXACT"},"end":{"value":236,"modifier":"EXACT"}},"description":"Neurotransmitter-gated ion-channel ligand-binding","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF02931"}]},{"type":"Domain","location":{"start":{"value":243,"modifier":"EXACT"},"end":{"value":480,"modifier":"EXACT"}},"description":"Neurotransmitter-gated ion-channel transmembrane","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF02932"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023303"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000687"}],"id":"KW-0407","category":"Molecular function","name":"Ion channel"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023065"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000687"}],"id":"KW-0406","category":"Biological process","name":"Ion transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023286"}],"id":"KW-1071","category":"Molecular function","name":"Ligand-gated ion channel"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000687"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0A1B0GVD7"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023170"}],"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000687"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023018"}],"id":"KW-0770","category":"Cellular component","name":"Synapse"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000687"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000687"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000687"}],"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000490474.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000490474.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16710414","citationType":"journal article","authors":["Gregory S.G.","Barlow K.F.","McLay K.E.","Kaul R.","Swarbreck D.","Dunham A.","Scott C.E.","Howe K.L.","Woodfine K.","Spencer C.C.","Jones M.C.","Gillson C.","Searle S.","Zhou Y.","Kokocinski F.","McDonald L.","Evans R.","Phillips K.","Atkinson A.","Cooper R.","Jones C.","Hall R.E.","Andrews T.D.","Lloyd C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Anderson F.","Andrew R.W.","Ashwell R.I.","Aubin K.","Babbage A.K.","Bagguley C.L.","Bailey J.","Beasley H.","Bethel G.","Bird C.P.","Bray-Allen S.","Brown J.Y.","Brown A.J.","Buckley D.","Burton J.","Bye J.","Carder C.","Chapman J.C.","Clark S.Y.","Clarke G.","Clee C.","Cobley V.","Collier R.E.","Corby N.","Coville G.J.","Davies J.","Deadman R.","Dunn M.","Earthrowl M.","Ellington A.G.","Errington H.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Gay L.","Ghori M.R.","Gibson R.","Gilby L.M.","Gillett W.","Glithero R.J.","Grafham D.V.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Hammond S.","Harrison E.S.","Hart E.","Haugen E.","Heath P.D.","Holmes S.","Holt K.","Howden P.J.","Hunt A.R.","Hunt S.E.","Hunter G.","Isherwood J.","James R.","Johnson C.","Johnson D.","Joy A.","Kay M.","Kershaw J.K.","Kibukawa M.","Kimberley A.M.","King A.","Knights A.J.","Lad H.","Laird G.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Loveland J.","Lovell J.","Lush M.J.","Lyne R.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","Matthews N.S.","McLaren S.","Milne S.","Mistry S.","Moore M.J.","Nickerson T.","O'Dell C.N.","Oliver K.","Palmeiri A.","Palmer S.A.","Parker A.","Patel D.","Pearce A.V.","Peck A.I.","Pelan S.","Phelps K.","Phillimore B.J.","Plumb R.","Rajan J.","Raymond C.","Rouse G.","Saenphimmachak C.","Sehra H.K.","Sheridan E.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.","Steward C.","Subramanian S.","Sycamore N.","Tracey A.","Tromans A.","Van Helmond Z.","Wall M.","Wallis J.M.","White S.","Whitehead S.L.","Wilkinson J.E.","Willey D.L.","Williams H.","Wilming L.","Wray P.W.","Wu Z.","Coulson A.","Vaudin M.","Sulston J.E.","Durbin R.","Hubbard T.","Wooster R.","Dunham I.","Carter N.P.","McVean G.","Ross M.T.","Harrow J.","Olson M.V.","Beck S.","Rogers J.","Bentley D.R.","Banerjee R.","Bryant S.P.","Burford D.C.","Burrill W.D.","Clegg S.M.","Dhami P.","Dovey O.","Faulkner L.M.","Gribble S.M.","Langford C.F.","Pandian R.D.","Porter K.M.","Prigmore E."],"citationCrossReferences":[{"database":"PubMed","id":"16710414"},{"database":"DOI","id":"10.1038/nature04727"}],"title":"The DNA sequence and biological annotation of human chromosome 1.","publicationDate":"2006","journal":"Nature","firstPage":"315","lastPage":"321","volume":"441"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000490474.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000490474.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL592078","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A1B0GVD7","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0A1B0GVD7","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"A0A1B0GVD7","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"20401","properties":[{"key":"antibodies","value":"268 antibodies from 35 providers"}]},{"database":"Ensembl","id":"ENST00000637900.1","properties":[{"key":"ProteinId","value":"ENSP00000490474.1"},{"key":"GeneId","value":"ENSG00000160716.6"}]},{"database":"HGNC","id":"HGNC:1962","properties":[{"key":"GeneName","value":"CHRNB2"}]},{"database":"OpenTargets","id":"ENSG00000160716","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000160716","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000158417","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"MAWRSGP","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"5975154at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"CHRNB2","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"Bgee","id":"ENSG00000160716","properties":[{"key":"ExpressionPatterns","value":"Expressed in cervix squamous epithelium and 160 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"A0A1B0GVD7","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005892","properties":[{"key":"GoTerm","value":"C:acetylcholine-gated channel complex"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0045211","properties":[{"key":"GoTerm","value":"C:postsynaptic membrane"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0015464","properties":[{"key":"GoTerm","value":"F:acetylcholine receptor activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0022848","properties":[{"key":"GoTerm","value":"F:acetylcholine-gated monoatomic cation-selective channel activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0095500","properties":[{"key":"GoTerm","value":"P:acetylcholine receptor signaling pathway"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0035094","properties":[{"key":"GoTerm","value":"P:response to nicotine"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd19025","properties":[{"key":"EntryName","value":"LGIC_ECD_nAChR_B2"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd19064","properties":[{"key":"EntryName","value":"LGIC_TM_nAChR"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.390:FF:000028","properties":[{"key":"EntryName","value":"Cholinergic receptor nicotinic beta 2 subunit"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.70.170.10:FF:000006","properties":[{"key":"EntryName","value":"Cholinergic receptor nicotinic beta 2 subunit"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.390:FF:000008","properties":[{"key":"EntryName","value":"Cholinergic receptor nicotinic beta 4 subunit"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.70.170.10","properties":[{"key":"EntryName","value":"Neurotransmitter-gated ion-channel ligand-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.58.390","properties":[{"key":"EntryName","value":"Neurotransmitter-gated ion-channel transmembrane domain"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR006202","properties":[{"key":"EntryName","value":"Neur_chan_lig-bd"}]},{"database":"InterPro","id":"IPR036734","properties":[{"key":"EntryName","value":"Neur_chan_lig-bd_sf"}]},{"database":"InterPro","id":"IPR006201","properties":[{"key":"EntryName","value":"Neur_channel"}]},{"database":"InterPro","id":"IPR036719","properties":[{"key":"EntryName","value":"Neuro-gated_channel_TM_sf"}]},{"database":"InterPro","id":"IPR038050","properties":[{"key":"EntryName","value":"Neuro_actylchol_rec"}]},{"database":"InterPro","id":"IPR006029","properties":[{"key":"EntryName","value":"Neurotrans-gated_channel_TM"}]},{"database":"InterPro","id":"IPR018000","properties":[{"key":"EntryName","value":"Neurotransmitter_ion_chnl_CS"}]},{"database":"InterPro","id":"IPR002394","properties":[{"key":"EntryName","value":"Nicotinic_acetylcholine_rcpt"}]},{"database":"NCBIfam","id":"TIGR00860","properties":[{"key":"EntryName","value":"LIC"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR18945","properties":[{"key":"EntryName","value":"NEUROTRANSMITTER GATED ION CHANNEL"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02931","properties":[{"key":"EntryName","value":"Neur_chan_LBD"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02932","properties":[{"key":"EntryName","value":"Neur_chan_memb"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00254","properties":[{"key":"EntryName","value":"NICOTINICR"}]},{"database":"PRINTS","id":"PR00252","properties":[{"key":"EntryName","value":"NRIONCHANNEL"}]},{"database":"SUPFAM","id":"SSF90112","properties":[{"key":"EntryName","value":"Neurotransmitter-gated ion-channel transmembrane pore"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF63712","properties":[{"key":"EntryName","value":"Nicotinic receptor ligand binding domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00236","properties":[{"key":"EntryName","value":"NEUROTR_ION_CHANNEL"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MARRCGPVALLLGFGLLRLCSGVWGTDTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLAQLISVHEREQIMTTNVWLTQVSEWEDYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVLKSEVASLDDFTPSGEWDIVALPGRRNENPDDSTYVDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPALLFMQQPRHHCARQRLRLRRRQREREGAGALFFREAPGADSCTCFVNRASVQGLAGAFGAEPAPVAGPGRSGEPCGCGLREAVDGVRFIADHMRSEDDDQSVSEDWKYVAMVIDRLFLWIFVFVCVFGTIGMFLQPLFQNYTTTTFLHSDHSAPSSK","length":504,"molWeight":57205,"crc64":"7593CD1A408DACAD","md5":"CC4CC4FDC729042D77F8B6E7CC2F4DDA"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":3,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1,"Transmembrane":4,"Domain":2},"uniParcId":"UPI0007E52D04"}}]}