{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q96G23","secondaryAccessions":["D3DV06","Q5SZE5","Q9HD96","Q9NW79"],"uniProtkbId":"CERS2_HUMAN","entryAudit":{"firstPublicDate":"2004-08-16","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2001-12-01","entryVersion":205,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"17977534"}],"value":"Ceramide synthase 2"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"17977534"}],"value":"CerS2"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11543633"}],"value":"LAG1 longevity assurance homolog 2"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11543633"}],"value":"SP260"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Sphingosine N-acyltransferase CERS2"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20937905"}],"value":"2.3.1.24"}]},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.8"}],"value":"Tumor metastasis-suppressor gene 1 protein"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Very-long-chain ceramide synthase CERS2"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12869556"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17977534"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18165233"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18541923"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19728861"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20937905"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26887952"}],"value":"2.3.1.297"}]}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"17977534"},{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:14076"}],"value":"CERS2"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11543633"}],"value":"LASS2"},{"evidences":[{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.8"}],"value":"TMSG1"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q924Z4"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17977534"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18165233"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18541923"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19728861"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20937905"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22144673"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22661289"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26887952"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29632068"}],"value":"Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward very-long-chain fatty acyl-CoA (chain length C22-C27) (PubMed:17977534, PubMed:18165233, PubMed:18541923, PubMed:19728861, PubMed:20937905, PubMed:22144673, PubMed:22661289, PubMed:26887952, PubMed:29632068). N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively (By similarity) (PubMed:17977534, PubMed:18165233, PubMed:18541923, PubMed:19728861, PubMed:20937905, PubMed:22144673, PubMed:22661289, PubMed:26887952, PubMed:29632068). Plays a non-redundant role in the synthesis of ceramides with very-long-chain fatty acids in kidney, liver and brain. 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