{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P17676","secondaryAccessions":["A8K671","Q96IH2","Q9H4Z5"],"uniProtkbId":"CEBPB_HUMAN","entryAudit":{"firstPublicDate":"1990-08-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2003-08-22","entryVersion":245,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:1834"}],"value":"CCAAT/enhancer-binding protein beta"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:1834"}],"value":"C/EBP beta"}]},"alternativeNames":[{"fullName":{"value":"Liver activator protein"},"shortNames":[{"value":"LAP"}]},{"fullName":{"value":"Liver-enriched inhibitory protein"},"shortNames":[{"value":"LIP"}]},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"1741402"}],"value":"Nuclear factor NF-IL6"}},{"fullName":{"value":"Transcription factor 5"},"shortNames":[{"value":"TCF-5"}]}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:1834"}],"value":"CEBPB"},"synonyms":[{"value":"TCF5"}],"orfNames":[{"value":"PP9092"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P21272"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P28033"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12048245"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18647749"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20829347"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9374525"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"25451943"}],"value":"Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:12048245, PubMed:1741402, PubMed:18647749, PubMed:9374525). Also plays a significant role in adipogenesis, as well as in the gluconeogenic pathway, liver regeneration, and hematopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Its functional capacity is governed by protein interactions and post-translational protein modifications. During early embryogenesis, plays essential and redundant roles with CEBPA. Has a promitotic effect on many cell types such as hepatocytes and adipocytes but has an antiproliferative effect on T-cells by repressing MYC expression, facilitating differentiation along the T-helper 2 lineage. Binds to regulatory regions of several acute-phase and cytokines genes and plays a role in the regulation of acute-phase reaction and inflammation. Also plays a role in intracellular bacteria killing (By similarity). During adipogenesis, is rapidly expressed and, after activation by phosphorylation, induces CEBPA and PPARG, which turn on the series of adipocyte genes that give rise to the adipocyte phenotype. The delayed transactivation of the CEBPA and PPARG genes by CEBPB appears necessary to allow mitotic clonal expansion and thereby progression of terminal differentiation (PubMed:20829347). Essential for female reproduction because of a critical role in ovarian follicle development (By similarity). Restricts osteoclastogenesis: together with NFE2L1; represses expression of DSPP during odontoblast differentiation (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P28033"}],"value":"Essential for gene expression induction in activated macrophages. Plays a major role in immune responses such as CD4(+) T-cell response, granuloma formation and endotoxin shock. Not essential for intracellular bacteria killing"}],"commentType":"FUNCTION","molecule":"Isoform 2"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P21272"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P28033"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11741938"}],"value":"Acts as a dominant negative through heterodimerization with isoform 2 (PubMed:11741938). Promotes osteoblast differentiation and osteoclastogenesis (By similarity)"}],"commentType":"FUNCTION","molecule":"Isoform 3"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P21272"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P28033"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11018027"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11257229"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11792321"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20111005"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20829347"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27923061"}],"value":"Binds DNA as a homodimer and as a heterodimer (PubMed:11018027, PubMed:11257229, PubMed:11792321). Interacts with ATF4. Binds DNA as a heterodimer with ATF4 (PubMed:11018027). Interacts with MYB; within the complex, MYB and CEBPB bind to different promoter regions (PubMed:11792321). Can form stable heterodimers with CEBPD (PubMed:1741402). Can form stable heterodimers with CEBPA and CEBPE (By similarity). Interacts with SIX1 (PubMed:27923061). Isoform 2 and isoform 3 also form heterodimers. Interacts with TRIM28 and PTGES2. Interacts with PRDM16. Interacts with CCDC85B. Forms a complex with THOC5. Interacts with ZNF638; this interaction increases transcriptional activation. Interacts with CIDEA and CIDEC; these interactions increase transcriptional activation of a subset of CEBPB downstream target genes (By similarity). Interacts with DDIT3/CHOP (PubMed:20829347). Interacts with EP300; recruits EP300 to chromatin. Interacts with RORA; the interaction disrupts interaction with EP300. Interacts (not methylated) with MED23, MED26, SMARCA2, SMARCB1 and SMARCC1 (PubMed:20111005). Interacts with KAT2A and KAT2B (By similarity). Interacts with ATF5; EP300 is required for ATF5 and CEBPB interaction and DNA binding (By similarity). Interacts with NFE2L1; the heterodimer represses expression of DSPP during odontoblast differentiation (By similarity)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P17676","intActId":"EBI-969696"},"interactantTwo":{"uniProtKBAccession":"P18847","geneName":"ATF3","intActId":"EBI-712767"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P17676","intActId":"EBI-969696"},"interactantTwo":{"uniProtKBAccession":"P18848","geneName":"ATF4","intActId":"EBI-492498"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P17676","intActId":"EBI-969696"},"interactantTwo":{"uniProtKBAccession":"Q16520","geneName":"BATF","intActId":"EBI-749503"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P17676","intActId":"EBI-969696"},"interactantTwo":{"uniProtKBAccession":"Q86X55","geneName":"CARM1","intActId":"EBI-2339854"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P17676","intActId":"EBI-969696"},"interactantTwo":{"uniProtKBAccession":"P49715","geneName":"CEBPA","intActId":"EBI-1172054"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P17676","intActId":"EBI-969696"},"interactantTwo":{"uniProtKBAccession":"P49716","geneName":"CEBPD","intActId":"EBI-7962058"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P17676","intActId":"EBI-969696"},"interactantTwo":{"uniProtKBAccession":"P53567","geneName":"CEBPG","intActId":"EBI-740209"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P17676","intActId":"EBI-969696"},"interactantTwo":{"uniProtKBAccession":"P35638","geneName":"DDIT3","intActId":"EBI-742651"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P17676","intActId":"EBI-969696"},"interactantTwo":{"uniProtKBAccession":"P03372","geneName":"ESR1","intActId":"EBI-78473"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P17676","intActId":"EBI-969696"},"interactantTwo":{"uniProtKBAccession":"P15941","geneName":"MUC1","chainId":"PRO_0000317447","intActId":"EBI-10053698"},"numberOfExperiments":8,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P17676","intActId":"EBI-969696"},"interactantTwo":{"uniProtKBAccession":"P04637","geneName":"TP53","intActId":"EBI-366083"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P17676","intActId":"EBI-969696"},"interactantTwo":{"uniProtKBAccession":"P03120","geneName":"E2","intActId":"EBI-1779322"},"numberOfExperiments":2,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"P17676","intActId":"EBI-969696"},"interactantTwo":{"uniProtKBAccession":"P03122","geneName":"E2","intActId":"EBI-7028618"},"numberOfExperiments":3,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"P17676","intActId":"EBI-969696"},"interactantTwo":{"uniProtKBAccession":"P06422","geneName":"E2","intActId":"EBI-7136851"},"numberOfExperiments":4,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"P17676","intActId":"EBI-969696"},"interactantTwo":{"uniProtKBAccession":"P06790","geneName":"E2","intActId":"EBI-7010629"},"numberOfExperiments":4,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"P17676-1","intActId":"EBI-9997012"},"interactantTwo":{"uniProtKBAccession":"P63165","geneName":"SUMO1","intActId":"EBI-80140"},"numberOfExperiments":5,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P28033"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9374525"}],"value":"Translocates to the nucleus when phosphorylated at Ser-288. In T-cells when sumoylated drawn to pericentric heterochromatin thereby allowing proliferation (By similarity)"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20829347"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9374525"}],"value":"Cytoplasm","id":"SL-0086"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative initiation"],"isoforms":[{"name":{"value":"1"},"synonyms":[{"value":"C/EBPbeta-FL"}],"isoformIds":["P17676-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"synonyms":[{"value":"C/EBPbeta-LAP"}],"isoformIds":["P17676-2"],"sequenceIds":["VSP_053314"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"synonyms":[{"value":"C/EBPbeta-LIP"}],"isoformIds":["P17676-3"],"sequenceIds":["VSP_053313"],"isoformSequenceStatus":"Described"}]},{"texts":[{"value":"Expressed at low levels in the lung, kidney and spleen"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20829347"}],"value":"By ER stress"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17467953"}],"value":"The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"18647749"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"20111005"}],"value":"Methylated. Methylation at Arg-3 by CARM1 and at Lys-43 by EHMT2 inhibit transactivation activity. Methylation is probably inhibited by phosphorylation at Thr-235"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P28033"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12810706"}],"value":"Sumoylated by polymeric chains of SUMO2 or SUMO3 (PubMed:12810706). Sumoylation at Lys-174 is required for inhibition of T-cells proliferation. In adipocytes, sumoylation at Lys-174 by PIAS1 leads to ubiquitination and subsequent proteasomal degradation. Desumoylated by SENP2, which abolishes ubiquitination and stabilizes protein levels (By similarity)"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P28033"}],"value":"Ubiquitinated, leading to proteasomal degradation"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P28033"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11684016"}],"value":"Phosphorylated at Thr-235 by MAPK and CDK2, serves to prime phosphorylation at Thr-226 and Ser-231 by GSK3B and acquire DNA-binding as well as transactivation activities, required to induce adipogenesis. MAPK and CDK2 act sequentially to maintain Thr-235 in the primed phosphorylated state during mitotical cloning expansion and thereby progression of terminal differentiation. Phosphorylation at Thr-266 enhances transactivation activity. Phosphorylation at Ser-325 in response to calcium increases transactivation activity. Phosphorylated at Thr-235 by RPS6KA1 (PubMed:11684016)"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P28033"}],"value":"O-glycosylated, glycosylation at Ser-227 and Ser-228 prevents phosphorylation on Thr-235, Ser-231 and Thr-226 and DNA binding activity which delays the adipocyte differentiation program"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P28033"}],"value":"Acetylated. Acetylation at Lys-43 is an important and dynamic regulatory event that contributes to its ability to transactivate target genes, including those associated with adipogenesis and adipocyte function. Deacetylation by HDAC1 represses its transactivation activity. Acetylated by KAT2A and KAT2B within a cluster of lysine residues between amino acids 129-133, this acetylation is strongly induced by glucocorticoid treatment and enhances transactivation activity"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the bZIP family. C/EBP subfamily"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":345,"modifier":"EXACT"}},"description":"CCAAT/enhancer-binding protein beta","featureId":"PRO_0000076617"},{"type":"Domain","location":{"start":{"value":271,"modifier":"EXACT"},"end":{"value":334,"modifier":"EXACT"}},"description":"bZIP","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00978"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":24,"modifier":"EXACT"}},"description":"Required for Lys-174 sumoylation"},{"type":"Region","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":135,"modifier":"EXACT"}},"description":"Required for MYC transcriptional repression","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P28033"}]},{"type":"Region","location":{"start":{"value":46,"modifier":"EXACT"},"end":{"value":67,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":79,"modifier":"EXACT"},"end":{"value":116,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":157,"modifier":"EXACT"},"end":{"value":178,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":218,"modifier":"EXACT"},"end":{"value":271,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":275,"modifier":"EXACT"},"end":{"value":295,"modifier":"EXACT"}},"description":"Basic motif","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00978"}]},{"type":"Region","location":{"start":{"value":297,"modifier":"EXACT"},"end":{"value":304,"modifier":"EXACT"}},"description":"Leucine-zipper","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00978"}]},{"type":"Motif","location":{"start":{"value":116,"modifier":"EXACT"},"end":{"value":124,"modifier":"EXACT"}},"description":"9aaTAD"},{"type":"Compositional bias","location":{"start":{"value":47,"modifier":"EXACT"},"end":{"value":59,"modifier":"EXACT"}},"description":"Pro residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":84,"modifier":"EXACT"},"end":{"value":100,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":160,"modifier":"EXACT"},"end":{"value":171,"modifier":"EXACT"}},"description":"Pro residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":218,"modifier":"EXACT"},"end":{"value":232,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":3,"modifier":"EXACT"},"end":{"value":3,"modifier":"EXACT"}},"description":"Asymmetric dimethylarginine; by CARM1","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"20111005"}]},{"type":"Modified residue","location":{"start":{"value":43,"modifier":"EXACT"},"end":{"value":43,"modifier":"EXACT"}},"description":"N6-acetyllysine; alternate","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P28033"}]},{"type":"Modified residue","location":{"start":{"value":43,"modifier":"EXACT"},"end":{"value":43,"modifier":"EXACT"}},"description":"N6-methylated lysine; alternate","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P28033"}]},{"type":"Modified residue","location":{"start":{"value":129,"modifier":"EXACT"},"end":{"value":129,"modifier":"EXACT"}},"description":"N6-acetyllysine; by KAT2A and KAT2B","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P28033"}]},{"type":"Modified residue","location":{"start":{"value":132,"modifier":"EXACT"},"end":{"value":132,"modifier":"EXACT"}},"description":"N6-acetyllysine; by KAT2A and KAT2B","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P28033"}]},{"type":"Modified residue","location":{"start":{"value":133,"modifier":"EXACT"},"end":{"value":133,"modifier":"EXACT"}},"description":"N6-acetyllysine; by KAT2A and KAT2B; alternate","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P28033"}]},{"type":"Modified residue","location":{"start":{"value":226,"modifier":"EXACT"},"end":{"value":226,"modifier":"EXACT"}},"description":"Phosphothreonine; by GSK3-beta","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P28033"}]},{"type":"Modified residue","location":{"start":{"value":231,"modifier":"EXACT"},"end":{"value":231,"modifier":"EXACT"}},"description":"Phosphoserine; by GSK3-beta","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P28033"}]},{"type":"Modified residue","location":{"start":{"value":235,"modifier":"EXACT"},"end":{"value":235,"modifier":"EXACT"}},"description":"Phosphothreonine; by RPS6KA1, CDK2 and MAPK","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11684016"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18647749"}]},{"type":"Modified residue","location":{"start":{"value":266,"modifier":"EXACT"},"end":{"value":266,"modifier":"EXACT"}},"description":"Phosphothreonine; by RPS6KA1 and PKC/PRKCA","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P28033"}]},{"type":"Modified residue","location":{"start":{"value":288,"modifier":"EXACT"},"end":{"value":288,"modifier":"EXACT"}},"description":"Phosphoserine; by PKC/PRKCA","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"9374525"}]},{"type":"Modified residue","location":{"start":{"value":325,"modifier":"EXACT"},"end":{"value":325,"modifier":"EXACT"}},"description":"Phosphoserine; by CaMK2","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P28033"}]},{"type":"Glycosylation","location":{"start":{"value":227,"modifier":"EXACT"},"end":{"value":227,"modifier":"EXACT"}},"description":"O-linked (GlcNAc) serine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P28033"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":228,"modifier":"EXACT"},"end":{"value":228,"modifier":"EXACT"}},"description":"O-linked (GlcNAc) serine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P28033"}],"featureId":""},{"type":"Cross-link","location":{"start":{"value":133,"modifier":"EXACT"},"end":{"value":133,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"25218447"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"25772364"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":174,"modifier":"EXACT"},"end":{"value":174,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternate","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12810706"}]},{"type":"Cross-link","location":{"start":{"value":174,"modifier":"EXACT"},"end":{"value":174,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"25218447"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"25755297"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"25772364"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":185,"modifier":"EXACT"},"end":{"value":185,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":187,"modifier":"EXACT"},"end":{"value":187,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"25218447"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"25772364"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":260,"modifier":"EXACT"},"end":{"value":260,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"25218447"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"25772364"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":262,"modifier":"EXACT"},"end":{"value":262,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":332,"modifier":"EXACT"},"end":{"value":332,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":198,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000305"}],"featureId":"VSP_053313","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":23,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000305"}],"featureId":"VSP_053314","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":195,"modifier":"EXACT"},"end":{"value":195,"modifier":"EXACT"}},"description":"in dbSNP:rs4253440","featureCrossReferences":[{"database":"dbSNP","id":"rs4253440"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.3"}],"featureId":"VAR_016300","alternativeSequence":{"originalSequence":"G","alternativeSequences":["S"]}},{"type":"Mutagenesis","location":{"start":{"value":235,"modifier":"EXACT"},"end":{"value":235,"modifier":"EXACT"}},"description":"Loss of transactivation activity in response to IFNG.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12048245"}],"alternativeSequence":{"originalSequence":"T","alternativeSequences":["S"]}},{"type":"Mutagenesis","location":{"start":{"value":288,"modifier":"EXACT"},"end":{"value":288,"modifier":"EXACT"}},"description":"Loss of nuclear translocation.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9374525"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}},{"type":"Sequence conflict","location":{"start":{"value":241,"modifier":"EXACT"},"end":{"value":241,"modifier":"EXACT"}},"description":"in Ref. 8; no nucleotide entry","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"A","alternativeSequences":["P"]}},{"type":"Sequence conflict","location":{"start":{"value":253,"modifier":"EXACT"},"end":{"value":253,"modifier":"EXACT"}},"description":"in Ref. 1; CAA36794","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"A","alternativeSequences":["G"]}},{"type":"Beta strand","location":{"start":{"value":269,"modifier":"EXACT"},"end":{"value":271,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1H8A"}]},{"type":"Helix","location":{"start":{"value":272,"modifier":"EXACT"},"end":{"value":329,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6MG1"}]},{"type":"Turn","location":{"start":{"value":330,"modifier":"EXACT"},"end":{"value":332,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7L4V"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0007","category":"PTM","name":"Acetylation"},{"id":"KW-0010","category":"Molecular function","name":"Activator"},{"id":"KW-0024","category":"Coding sequence diversity","name":"Alternative initiation"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0221","category":"Biological process","name":"Differentiation"},{"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-1017","category":"PTM","name":"Isopeptide bond"},{"id":"KW-0488","category":"PTM","name":"Methylation"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0804","category":"Biological process","name":"Transcription"},{"id":"KW-0805","category":"Biological process","name":"Transcription regulation"},{"id":"KW-0832","category":"PTM","name":"Ubl conjugation"}],"references":[{"referenceNumber":1,"citation":{"id":"2112087","citationType":"journal article","authors":["Akira S.","Isshiki H.","Sugita T.","Tanabe O.","Kinoshita S.","Nishio Y.","Nakajima T.","Hirano T.","Kishimoto T."],"citationCrossReferences":[{"database":"PubMed","id":"2112087"},{"database":"DOI","id":"10.1002/j.1460-2075.1990.tb08316.x"}],"title":"A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family.","publicationDate":"1990","journal":"EMBO J.","firstPage":"1897","lastPage":"1906","volume":"9"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]","FUNCTION"],"referenceComments":[{"value":"Placenta","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"15498874","citationType":"journal article","authors":["Wan D.","Gong Y.","Qin W.","Zhang P.","Li J.","Wei L.","Zhou X.","Li H.","Qiu X.","Zhong F.","He L.","Yu J.","Yao G.","Jiang H.","Qian L.","Yu Y.","Shu H.","Chen X.","Xu H.","Guo M.","Pan Z.","Chen Y.","Ge C.","Yang S.","Gu J."],"citationCrossReferences":[{"database":"PubMed","id":"15498874"},{"database":"DOI","id":"10.1073/pnas.0404089101"}],"title":"Large-scale cDNA transfection screening for genes related to cancer development and progression.","publicationDate":"2004","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"15724","lastPage":"15729","volume":"101"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"]},{"referenceNumber":3,"citation":{"id":"CI-C65191F0NHL6L","citationType":"submission","authoringGroup":["SeattleSNPs variation discovery resource"],"publicationDate":"DEC-2002","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]","VARIANT SER-195"]},{"referenceNumber":4,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"Placenta","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"11780052","citationType":"journal article","authors":["Deloukas P.","Matthews L.H.","Ashurst J.L.","Burton J.","Gilbert J.G.R.","Jones M.","Stavrides G.","Almeida J.P.","Babbage A.K.","Bagguley C.L.","Bailey J.","Barlow K.F.","Bates K.N.","Beard L.M.","Beare D.M.","Beasley O.P.","Bird C.P.","Blakey S.E.","Bridgeman A.M.","Brown A.J.","Buck D.","Burrill W.D.","Butler A.P.","Carder C.","Carter N.P.","Chapman J.C.","Clamp M.","Clark G.","Clark L.N.","Clark S.Y.","Clee C.M.","Clegg S.","Cobley V.E.","Collier R.E.","Connor R.E.","Corby N.R.","Coulson A.","Coville G.J.","Deadman R.","Dhami P.D.","Dunn M.","Ellington A.G.","Frankland J.A.","Fraser A.","French L.","Garner P.","Grafham D.V.","Griffiths C.","Griffiths M.N.D.","Gwilliam R.","Hall R.E.","Hammond S.","Harley J.L.","Heath P.D.","Ho S.","Holden J.L.","Howden P.J.","Huckle E.","Hunt A.R.","Hunt S.E.","Jekosch K.","Johnson C.M.","Johnson D.","Kay M.P.","Kimberley A.M.","King A.","Knights A.","Laird G.K.","Lawlor S.","Lehvaeslaiho M.H.","Leversha M.A.","Lloyd C.","Lloyd D.M.","Lovell J.D.","Marsh V.L.","Martin S.L.","McConnachie L.J.","McLay K.","McMurray A.A.","Milne S.A.","Mistry D.","Moore M.J.F.","Mullikin J.C.","Nickerson T.","Oliver K.","Parker A.","Patel R.","Pearce T.A.V.","Peck A.I.","Phillimore B.J.C.T.","Prathalingam S.R.","Plumb R.W.","Ramsay H.","Rice C.M.","Ross M.T.","Scott C.E.","Sehra H.K.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.L.","Soderlund C.","Steward C.A.","Sulston J.E.","Swann R.M.","Sycamore N.","Taylor R.","Tee L.","Thomas D.W.","Thorpe A.","Tracey A.","Tromans A.C.","Vaudin M.","Wall M.","Wallis J.M.","Whitehead S.L.","Whittaker P.","Willey D.L.","Williams L.","Williams S.A.","Wilming L.","Wray P.W.","Hubbard T.","Durbin R.M.","Bentley D.R.","Beck S.","Rogers J."],"citationCrossReferences":[{"database":"PubMed","id":"11780052"},{"database":"DOI","id":"10.1038/414865a"}],"title":"The DNA sequence and comparative analysis of human chromosome 20.","publicationDate":"2001","journal":"Nature","firstPage":"865","lastPage":"871","volume":"414"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":6,"citation":{"id":"CI-5GBD0VIIJ7C63","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"SEP-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":7,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"Muscle","type":"TISSUE"},{"value":"Skin","type":"TISSUE"}]},{"referenceNumber":8,"citation":{"id":"7635140","citationType":"journal article","authors":["Toda K.","Akira S.","Kishimoto T.","Sasaki H.","Hashimoto K.","Yamamoto Y.","Sagara Y.","Shizuta Y."],"citationCrossReferences":[{"database":"PubMed","id":"7635140"},{"database":"DOI","id":"10.1111/j.1432-1033.1995.tb20699.x"}],"title":"Identification of a transcriptional regulatory factor for human aromatase cytochrome P450 gene expression as nuclear factor interleukin-6 (NF-IL6), a member of the CCAAT/enhancer-binding protein family.","publicationDate":"1995","journal":"Eur. J. Biochem.","firstPage":"292","lastPage":"299","volume":"231"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF 241-323 (ISOFORMS 1/2/3)"]},{"referenceNumber":9,"citation":{"id":"1741402","citationType":"journal article","authors":["Kinoshita S.","Akira S.","Kishimoto T."],"citationCrossReferences":[{"database":"PubMed","id":"1741402"},{"database":"DOI","id":"10.1073/pnas.89.4.1473"}],"title":"A member of the C/EBP family, NF-IL6 beta, forms a heterodimer and transcriptionally synergizes with NF-IL6.","publicationDate":"1992","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"1473","lastPage":"1476","volume":"89"},"referencePositions":["FUNCTION","INTERACTION WITH CEBPD"]},{"referenceNumber":10,"citation":{"id":"9374525","citationType":"journal article","authors":["Chinery R.","Brockman J.A.","Dransfield D.T.","Coffey R.J."],"citationCrossReferences":[{"database":"PubMed","id":"9374525"},{"database":"DOI","id":"10.1074/jbc.272.48.30356"}],"title":"Antioxidant-induced nuclear translocation of CCAAT/enhancer-binding protein beta. A critical role for protein kinase A-mediated phosphorylation of Ser299.","publicationDate":"1997","journal":"J. Biol. Chem.","firstPage":"30356","lastPage":"30361","volume":"272"},"referencePositions":["FUNCTION","PHOSPHORYLATION AT SER-288","MUTAGENESIS OF SER-288","SUBCELLULAR LOCATION"]},{"referenceNumber":11,"citation":{"id":"11018027","citationType":"journal article","authors":["Podust L.M.","Krezel A.M.","Kim Y."],"citationCrossReferences":[{"database":"PubMed","id":"11018027"},{"database":"DOI","id":"10.1074/jbc.m005594200"}],"title":"Crystal structure of the CCAAT box/enhancer-binding protein beta activating transcription factor-4 basic leucine zipper heterodimer in the absence of DNA.","publicationDate":"2001","journal":"J. Biol. Chem.","firstPage":"505","lastPage":"513","volume":"276"},"referencePositions":["INTERACTION WITH ATF4","DNA-BINDING"]},{"referenceNumber":12,"citation":{"id":"11684016","citationType":"journal article","authors":["Buck M.","Poli V.","Hunter T.","Chojkier M."],"citationCrossReferences":[{"database":"PubMed","id":"11684016"},{"database":"DOI","id":"10.1016/s1097-2765(01)00374-4"}],"title":"C/EBPbeta phosphorylation by RSK creates a functional XEXD caspase inhibitory box critical for cell survival.","publicationDate":"2001","journal":"Mol. Cell","firstPage":"807","lastPage":"816","volume":"8"},"referencePositions":["PHOSPHORYLATION AT THR-235"]},{"referenceNumber":13,"citation":{"id":"11741938","citationType":"journal article","authors":["Zhu Y.","Saunders M.A.","Yeh H.","Deng W.G.","Wu K.K."],"citationCrossReferences":[{"database":"PubMed","id":"11741938"},{"database":"DOI","id":"10.1074/jbc.m108075200"}],"title":"Dynamic regulation of cyclooxygenase-2 promoter activity by isoforms of CCAAT/enhancer-binding proteins.","publicationDate":"2002","journal":"J. Biol. Chem.","firstPage":"6923","lastPage":"6928","volume":"277"},"referencePositions":["FUNCTION (ISOFORM 3)","ALTERNATIVE SPLICING (ISOFORMS 1; 2 AND 3)","DNA-BINDING"]},{"referenceNumber":14,"citation":{"id":"12048245","citationType":"journal article","authors":["Roy S.K.","Hu J.","Meng Q.","Xia Y.","Shapiro P.S.","Reddy S.P.","Platanias L.C.","Lindner D.J.","Johnson P.F.","Pritchard C.","Pages G.","Pouyssegur J.","Kalvakolanu D.V."],"citationCrossReferences":[{"database":"PubMed","id":"12048245"},{"database":"DOI","id":"10.1073/pnas.122075799"}],"title":"MEKK1 plays a critical role in activating the transcription factor C/EBP-beta-dependent gene expression in response to IFN-gamma.","publicationDate":"2002","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"7945","lastPage":"7950","volume":"99"},"referencePositions":["FUNCTION","MUTAGENESIS OF THR-235"]},{"referenceNumber":15,"citation":{"id":"12810706","citationType":"journal article","authors":["Eaton E.M.","Sealy L."],"citationCrossReferences":[{"database":"PubMed","id":"12810706"},{"database":"DOI","id":"10.1074/jbc.m305680200"}],"title":"Modification of CCAAT/enhancer-binding protein-beta by the small ubiquitin-like modifier (SUMO) family members, SUMO-2 and SUMO-3.","publicationDate":"2003","journal":"J. Biol. Chem.","firstPage":"33416","lastPage":"33421","volume":"278"},"referencePositions":["SUMOYLATION AT LYS-174"]},{"referenceNumber":16,"citation":{"id":"17467953","citationType":"journal article","authors":["Piskacek S.","Gregor M.","Nemethova M.","Grabner M.","Kovarik P.","Piskacek M."],"citationCrossReferences":[{"database":"PubMed","id":"17467953"},{"database":"DOI","id":"10.1016/j.ygeno.2007.02.003"}],"title":"Nine-amino-acid transactivation domain: establishment and prediction utilities.","publicationDate":"2007","journal":"Genomics","firstPage":"756","lastPage":"768","volume":"89"},"referencePositions":["DOMAIN"]},{"referenceNumber":17,"citation":{"id":"18647749","citationType":"journal article","authors":["Pless O.","Kowenz-Leutz E.","Knoblich M.","Lausen J.","Beyermann M.","Walsh M.J.","Leutz A."],"citationCrossReferences":[{"database":"PubMed","id":"18647749"},{"database":"DOI","id":"10.1074/jbc.m802132200"}],"title":"G9a-mediated lysine methylation alters the function of CCAAT/enhancer-binding protein-beta.","publicationDate":"2008","journal":"J. Biol. Chem.","firstPage":"26357","lastPage":"26363","volume":"283"},"referencePositions":["FUNCTION","PHOSPHORYLATION AT THR-235"]},{"referenceNumber":18,"citation":{"id":"19413330","citationType":"journal article","authors":["Gauci S.","Helbig A.O.","Slijper M.","Krijgsveld J.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"19413330"},{"database":"DOI","id":"10.1021/ac9004309"}],"title":"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.","publicationDate":"2009","journal":"Anal. Chem.","firstPage":"4493","lastPage":"4501","volume":"81"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":19,"citation":{"id":"20111005","citationType":"journal article","authors":["Kowenz-Leutz E.","Pless O.","Dittmar G.","Knoblich M.","Leutz A."],"citationCrossReferences":[{"database":"PubMed","id":"20111005"},{"database":"DOI","id":"10.1038/emboj.2010.3"}],"title":"Crosstalk between C/EBPbeta phosphorylation, arginine methylation, and SWI/SNF/Mediator implies an indexing transcription factor code.","publicationDate":"2010","journal":"EMBO J.","firstPage":"1105","lastPage":"1115","volume":"29"},"referencePositions":["INTERACTION WITH MED23; MED26; SMARCA2; SMARCB1 AND SMARCC1","METHYLATION AT ARG-3"]},{"referenceNumber":20,"citation":{"id":"20829347","citationType":"journal article","authors":["Park S.H.","Choi H.J.","Yang H.","Do K.H.","Kim J.","Lee D.W.","Moon Y."],"citationCrossReferences":[{"database":"PubMed","id":"20829347"},{"database":"DOI","id":"10.1074/jbc.m110.136259"}],"title":"Endoplasmic reticulum stress-activated C/EBP homologous protein enhances nuclear factor-kappaB signals via repression of peroxisome proliferator-activated receptor gamma.","publicationDate":"2010","journal":"J. Biol. Chem.","firstPage":"35330","lastPage":"35339","volume":"285"},"referencePositions":["FUNCTION","INTERACTION WITH DDIT3","SUBCELLULAR LOCATION","INDUCTION"]},{"referenceNumber":21,"citation":{"id":"25218447","citationType":"journal article","authors":["Hendriks I.A.","D'Souza R.C.","Yang B.","Verlaan-de Vries M.","Mann M.","Vertegaal A.C."],"citationCrossReferences":[{"database":"PubMed","id":"25218447"},{"database":"DOI","id":"10.1038/nsmb.2890"}],"title":"Uncovering global SUMOylation signaling networks in a site-specific manner.","publicationDate":"2014","journal":"Nat. Struct. Mol. Biol.","firstPage":"927","lastPage":"936","volume":"21"},"referencePositions":["SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-133; LYS-174; LYS-187 AND LYS-260","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":22,"citation":{"id":"25772364","citationType":"journal article","authors":["Hendriks I.A.","Treffers L.W.","Verlaan-de Vries M.","Olsen J.V.","Vertegaal A.C."],"citationCrossReferences":[{"database":"PubMed","id":"25772364"},{"database":"DOI","id":"10.1016/j.celrep.2015.02.033"}],"title":"SUMO-2 orchestrates chromatin modifiers in response to DNA damage.","publicationDate":"2015","journal":"Cell Rep.","firstPage":"1778","lastPage":"1791","volume":"10"},"referencePositions":["SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-133; LYS-174; LYS-187 AND LYS-260","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":23,"citation":{"id":"25451943","citationType":"journal article","authors":["Guo L.","Li X.","Tang Q."],"citationCrossReferences":[{"database":"PubMed","id":"25451943"},{"database":"DOI","id":"10.1074/jbc.r114.619957"}],"title":"Transcriptional Regulation of Adipocyte Differentiation: A Central Role for CCAAT/Enhancer-binding Protein (C/EBP) beta.","publicationDate":"2015","journal":"J. Biol. Chem.","firstPage":"755","lastPage":"761","volume":"290"},"referencePositions":["REVIEW OF PTMS AND FUNCTION"]},{"referenceNumber":24,"citation":{"id":"25755297","citationType":"journal article","authors":["Xiao Z.","Chang J.G.","Hendriks I.A.","Sigurdsson J.O.","Olsen J.V.","Vertegaal A.C."],"citationCrossReferences":[{"database":"PubMed","id":"25755297"},{"database":"DOI","id":"10.1074/mcp.o114.044792"}],"title":"System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.","publicationDate":"2015","journal":"Mol. Cell. Proteomics","firstPage":"1419","lastPage":"1434","volume":"14"},"referencePositions":["SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-174","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":25,"citation":{"id":"27923061","citationType":"journal article","authors":["Brunmeir R.","Wu J.","Peng X.","Kim S.Y.","Julien S.G.","Zhang Q.","Xie W.","Xu F."],"citationCrossReferences":[{"database":"PubMed","id":"27923061"},{"database":"DOI","id":"10.1371/journal.pgen.1006474"}],"title":"Comparative Transcriptomic and Epigenomic Analyses Reveal New Regulators of Murine Brown Adipogenesis.","publicationDate":"2016","journal":"PLoS Genet.","firstPage":"E1006474","lastPage":"E1006474","volume":"12"},"referencePositions":["INTERACTION WITH SIX1"]},{"referenceNumber":26,"citation":{"id":"28112733","citationType":"journal article","authors":["Hendriks I.A.","Lyon D.","Young C.","Jensen L.J.","Vertegaal A.C.","Nielsen M.L."],"citationCrossReferences":[{"database":"PubMed","id":"28112733"},{"database":"DOI","id":"10.1038/nsmb.3366"}],"title":"Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.","publicationDate":"2017","journal":"Nat. Struct. Mol. Biol.","firstPage":"325","lastPage":"336","volume":"24"},"referencePositions":["SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-133; LYS-174; LYS-185; LYS-187; LYS-260; LYS-262 AND LYS-332","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":27,"citation":{"id":"11257229","citationType":"journal article","authors":["Tahirov T.H.","Inoue-Bungo T.","Morii H.","Fujikawa A.","Sasaki M.","Kimura K.","Shiina M.","Sato K.","Kumasaka T.","Yamamoto M.","Ishii S.","Ogata K."],"citationCrossReferences":[{"database":"PubMed","id":"11257229"},{"database":"DOI","id":"10.1016/s0092-8674(01)00271-9"}],"title":"Structural analyses of DNA recognition by the AML1/Runx-1 Runt domain and its allosteric control by CBFbeta.","publicationDate":"2001","journal":"Cell","firstPage":"755","lastPage":"767","volume":"104"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (3.00 ANGSTROMS) OF 259-336 IN COMPLEXES WITH DNA","SUBUNIT"]},{"referenceNumber":28,"citation":{"id":"11792321","citationType":"journal article","authors":["Tahirov T.H.","Sato K.","Ichikawa-Iwata E.","Sasaki M.","Inoue-Bungo T.","Shiina M.","Kimura K.","Takata S.","Fujikawa A.","Morii H.","Kumasaka T.","Yamamoto M.","Ishii S.","Ogata K."],"citationCrossReferences":[{"database":"PubMed","id":"11792321"},{"database":"DOI","id":"10.1016/s0092-8674(01)00636-5"}],"title":"Mechanism of c-Myb-C/EBP beta cooperation from separated sites on a promoter.","publicationDate":"2002","journal":"Cell","firstPage":"57","lastPage":"70","volume":"108"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.23 ANGSTROMS) OF 259-345 IN COMPLEX WITH MOUSE MYB","SUBUNIT","INTERACTION WITH MYB","DNA-BINDING"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"X52560","properties":[{"key":"ProteinId","value":"CAA36794.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF289608","properties":[{"key":"ProteinId","value":"AAL55792.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AY193834","properties":[{"key":"ProteinId","value":"AAN86350.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AK291536","properties":[{"key":"ProteinId","value":"BAF84225.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AL161937","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471077","properties":[{"key":"ProteinId","value":"EAW75629.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC007538","properties":[{"key":"ProteinId","value":"AAH07538.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC021931","properties":[{"key":"ProteinId","value":"AAH21931.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS13429.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P17676-1"},{"database":"PIR","id":"S12788","properties":[{"key":"EntryName","value":"S12788"}]},{"database":"PIR","id":"S66246","properties":[{"key":"EntryName","value":"S66246"}]},{"database":"RefSeq","id":"NP_001272807.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001285878.1"}],"isoformId":"P17676-2"},{"database":"RefSeq","id":"NP_001272808.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001285879.1"}],"isoformId":"P17676-3"},{"database":"RefSeq","id":"NP_005185.2","properties":[{"key":"NucleotideSequenceId","value":"NM_005194.4"}],"isoformId":"P17676-1"},{"database":"PDB","id":"1GTW","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.85 A"},{"key":"Chains","value":"A/B=259-336"}]},{"database":"PDB","id":"1GU4","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A/B=259-336"}]},{"database":"PDB","id":"1GU5","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.10 A"},{"key":"Chains","value":"A/B=259-336"}]},{"database":"PDB","id":"1H88","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.80 A"},{"key":"Chains","value":"A/B=259-336"}]},{"database":"PDB","id":"1H89","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.45 A"},{"key":"Chains","value":"A/B=273-336"}]},{"database":"PDB","id":"1H8A","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.23 A"},{"key":"Chains","value":"A/B=259-336"}]},{"database":"PDB","id":"1HJB","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.00 A"},{"key":"Chains","value":"A/B/D/E=259-345"}]},{"database":"PDB","id":"1IO4","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.00 A"},{"key":"Chains","value":"A/B=259-336"}]},{"database":"PDB","id":"2E42","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A/B=259-336"}]},{"database":"PDB","id":"2E43","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.10 A"},{"key":"Chains","value":"A/B=259-336"}]},{"database":"PDB","id":"6MG1","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.75 A"},{"key":"Chains","value":"A/B=269-344"}]},{"database":"PDB","id":"6MG2","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.93 A"},{"key":"Chains","value":"A/B=269-344"}]},{"database":"PDB","id":"6MG3","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.05 A"},{"key":"Chains","value":"A/B=269-344"}]},{"database":"PDB","id":"7L4V","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.75 A"},{"key":"Chains","value":"A/B=269-344"}]},{"database":"PDB","id":"7UPZ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.49 A"},{"key":"Chains","value":"A/B=257-336"}]},{"database":"PDB","id":"8K8D","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.20 A"},{"key":"Chains","value":"A/B=259-336"}]},{"database":"PDBsum","id":"1GTW","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1GU4","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1GU5","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1H88","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1H89","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1H8A","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1HJB","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1IO4","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2E42","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2E43","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6MG1","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6MG2","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6MG3","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7L4V","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7UPZ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8K8D","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"P17676","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P17676","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"107480","properties":[{"key":"Interactions","value":"1430"}]},{"database":"ComplexPortal","id":"CPX-3361","properties":[{"key":"EntryName","value":"bZIP transcription factor complex, CEBPB-CEBPB"}]},{"database":"ComplexPortal","id":"CPX-504","properties":[{"key":"EntryName","value":"c-Myb-C/EBPbeta complex"}]},{"database":"ComplexPortal","id":"CPX-509","properties":[{"key":"EntryName","value":"bZIP transcription factor complex, CEBPA-CEBPB"}]},{"database":"ComplexPortal","id":"CPX-6470","properties":[{"key":"EntryName","value":"bZIP transcription factor complex, ATF3-CEBPB"}]},{"database":"ComplexPortal","id":"CPX-6471","properties":[{"key":"EntryName","value":"bZIP transcription factor complex, ATF3-CEBPG"}]},{"database":"ComplexPortal","id":"CPX-6526","properties":[{"key":"EntryName","value":"bZIP transcription factor complex, ATF4-CEBPB"}]},{"database":"ComplexPortal","id":"CPX-70","properties":[{"key":"EntryName","value":"bZIP transcription factor complex, CEBPB-DDIT3"}]},{"database":"ComplexPortal","id":"CPX-7007","properties":[{"key":"EntryName","value":"bZIP transcription factor complex, BATF-CEBPB"}]},{"database":"ComplexPortal","id":"CPX-7096","properties":[{"key":"EntryName","value":"bZIP transcription factor complex, BATF3-CEBPB"}]},{"database":"CORUM","id":"P17676","properties":[{"key":"Description","value":"-"}]},{"database":"DIP","id":"DIP-35345N","properties":[{"key":"Description","value":"-"}]},{"database":"ELM","id":"P17676","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P17676","properties":[{"key":"Number of interactors","value":"5648"}]},{"database":"IntAct","id":"P17676","properties":[{"key":"Interactions","value":"39"}]},{"database":"MINT","id":"P17676","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-CEBPB","properties":[{"key":"Evidences","value":"38 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000305422","properties":[{"key":"Description","value":"-"}]},{"database":"DrugBank","id":"DB04216","properties":[{"key":"GenericName","value":"Quercetin"}]},{"database":"GlyCosmos","id":"P17676","properties":[{"key":"glycosylation","value":"2 sites, No reported glycans"}]},{"database":"GlyGen","id":"P17676","properties":[{"key":"glycosylation","value":"4 sites, 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"P17676","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"P17676","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"P17676","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"CEBPB","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"34223718","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"P17676","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"P17676","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000305422","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P17676","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"53503","properties":[{"key":"Description","value":"-"}],"isoformId":"P17676-1"},{"database":"Pumba","id":"P17676","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"3782","properties":[{"key":"antibodies","value":"673 antibodies from 44 providers"}]},{"database":"DNASU","id":"1051","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000303004.5","properties":[{"key":"ProteinId","value":"ENSP00000305422.3"},{"key":"GeneId","value":"ENSG00000172216.7"}],"isoformId":"P17676-1"},{"database":"Ensembl","id":"ENST00000718336.1","properties":[{"key":"ProteinId","value":"ENSP00000520773.1"},{"key":"GeneId","value":"ENSG00000172216.7"}],"isoformId":"P17676-1"},{"database":"GeneID","id":"1051","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:1051","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000303004.5","properties":[{"key":"ProteinId","value":"ENSP00000305422.3"},{"key":"RefSeqNucleotideId","value":"NM_005194.4"},{"key":"RefSeqProteinId","value":"NP_005185.2"}]},{"database":"UCSC","id":"uc002xvi.4","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"P17676-1"},{"database":"AGR","id":"HGNC:1834","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA26377","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"1051","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"1051","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"CEBPB","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:1834","properties":[{"key":"GeneName","value":"CEBPB"}]},{"database":"HPA","id":"ENSG00000172216","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MIM","id":"189965","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000172216","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000172216","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG3119","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000162137","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_043327_1_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P17676","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"RLVAWDQ","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"10032067at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"P17676","properties":[{"key":"Number of GO annotations","value":"4 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"P17676","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"P17676","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-2559582","properties":[{"key":"PathwayName","value":"Senescence-Associated Secretory Phenotype (SASP)"}]},{"database":"Reactome","id":"R-HSA-380994","properties":[{"key":"PathwayName","value":"ATF4 activates genes in response to endoplasmic reticulum stress"}]},{"database":"Reactome","id":"R-HSA-381340","properties":[{"key":"PathwayName","value":"Transcriptional regulation of white adipocyte differentiation"}]},{"database":"Reactome","id":"R-HSA-8853884","properties":[{"key":"PathwayName","value":"Transcriptional Regulation by VENTX"}]},{"database":"Reactome","id":"R-HSA-9616222","properties":[{"key":"PathwayName","value":"Transcriptional regulation of granulopoiesis"}]},{"database":"Reactome","id":"R-HSA-9633012","properties":[{"key":"PathwayName","value":"Response of EIF2AK4 (GCN2) to amino acid deficiency"}]},{"database":"Reactome","id":"R-HSA-9648895","properties":[{"key":"PathwayName","value":"Response of EIF2AK1 (HRI) to heme deficiency"}]},{"database":"Reactome","id":"R-HSA-9725371","properties":[{"key":"PathwayName","value":"Nuclear events stimulated by ALK signaling in cancer"}]},{"database":"SignaLink","id":"P17676","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"P17676","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000172216","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"1051","properties":[{"key":"hits","value":"69 hits in 1187 CRISPR screens"}]},{"database":"CD-CODE","id":"804901D1","properties":[{"key":"EntryName","value":"Nuclear speckle"}]},{"database":"ChiTaRS","id":"CEBPB","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"P17676","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"CEBPB","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"1051","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"P17676","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:P17676","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 20"}]},{"database":"RNAct","id":"P17676","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000172216","properties":[{"key":"ExpressionPatterns","value":"Expressed in lower lobe of lung and 208 other cell types or tissues"}]},{"database":"GO","id":"GO:1990647","properties":[{"key":"GoTerm","value":"C:C/EBP complex"},{"key":"GoEvidenceType","value":"IPI:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"20102225"}]},{"database":"GO","id":"GO:0036488","properties":[{"key":"GoTerm","value":"C:CHOP-C/EBP complex"},{"key":"GoEvidenceType","value":"IPI:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"20102225"}]},{"database":"GO","id":"GO:0000785","properties":[{"key":"GoTerm","value":"C:chromatin"},{"key":"GoEvidenceType","value":"ISA:NTNU_SB"}]},{"database":"GO","id":"GO:0000779","properties":[{"key":"GoTerm","value":"C:condensed chromosome, centromeric region"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9374525"}]},{"database":"GO","id":"GO:0016363","properties":[{"key":"GoTerm","value":"C:nuclear matrix"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20829347"}]},{"database":"GO","id":"GO:0090575","properties":[{"key":"GoTerm","value":"C:RNA polymerase II transcription regulator complex"},{"key":"GoEvidenceType","value":"IPI:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"20102225"}]},{"database":"GO","id":"GO:0031490","properties":[{"key":"GoTerm","value":"F:chromatin DNA binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0003677","properties":[{"key":"GoTerm","value":"F:DNA binding"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"10821850"}]},{"database":"GO","id":"GO:0001228","properties":[{"key":"GoTerm","value":"F:DNA-binding transcription activator activity, RNA polymerase II-specific"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0003700","properties":[{"key":"GoTerm","value":"F:DNA-binding transcription factor activity"},{"key":"GoEvidenceType","value":"NAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"10821850"}]},{"database":"GO","id":"GO:0000981","properties":[{"key":"GoTerm","value":"F:DNA-binding transcription factor activity, RNA polymerase II-specific"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0001227","properties":[{"key":"GoTerm","value":"F:DNA-binding transcription repressor activity, RNA polymerase II-specific"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"PubMed","id":"15308669"}]},{"database":"GO","id":"GO:0035035","properties":[{"key":"GoTerm","value":"F:histone acetyltransferase binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0042826","properties":[{"key":"GoTerm","value":"F:histone deacetylase binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0019900","properties":[{"key":"GoTerm","value":"F:kinase binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0035259","properties":[{"key":"GoTerm","value":"F:nuclear glucocorticoid receptor binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0046982","properties":[{"key":"GoTerm","value":"F:protein heterodimerization activity"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0042803","properties":[{"key":"GoTerm","value":"F:protein homodimerization activity"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0000978","properties":[{"key":"GoTerm","value":"F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0000979","properties":[{"key":"GoTerm","value":"F:RNA polymerase II core promoter sequence-specific DNA binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0000977","properties":[{"key":"GoTerm","value":"F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"7959007"}]},{"database":"GO","id":"GO:1990837","properties":[{"key":"GoTerm","value":"F:sequence-specific double-stranded DNA binding"},{"key":"GoEvidenceType","value":"IDA:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"28473536"}]},{"database":"GO","id":"GO:0000976","properties":[{"key":"GoTerm","value":"F:transcription cis-regulatory region binding"},{"key":"GoEvidenceType","value":"IDA:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"30355733"}]},{"database":"GO","id":"GO:0044389","properties":[{"key":"GoTerm","value":"F:ubiquitin-like protein ligase binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0006953","properties":[{"key":"GoTerm","value":"P:acute-phase response"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"2112087"}]},{"database":"GO","id":"GO:0050873","properties":[{"key":"GoTerm","value":"P:brown fat cell differentiation"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0071347","properties":[{"key":"GoTerm","value":"P:cellular response to interleukin-1"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0071222","properties":[{"key":"GoTerm","value":"P:cellular response to lipopolysaccharide"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0042742","properties":[{"key":"GoTerm","value":"P:defense response to bacterium"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0006351","properties":[{"key":"GoTerm","value":"P:DNA-templated transcription"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0002432","properties":[{"key":"GoTerm","value":"P:granuloma formation"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0072574","properties":[{"key":"GoTerm","value":"P:hepatocyte proliferation"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0006955","properties":[{"key":"GoTerm","value":"P:immune response"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"2112087"}]},{"database":"GO","id":"GO:0006954","properties":[{"key":"GoTerm","value":"P:inflammatory response"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"2112087"}]},{"database":"GO","id":"GO:0140467","properties":[{"key":"GoTerm","value":"P:integrated stress response signaling"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"28566324"}]},{"database":"GO","id":"GO:0070059","properties":[{"key":"GoTerm","value":"P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress"},{"key":"GoEvidenceType","value":"TAS:ParkinsonsUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"14685163"}]},{"database":"GO","id":"GO:0097421","properties":[{"key":"GoTerm","value":"P:liver regeneration"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0007613","properties":[{"key":"GoTerm","value":"P:memory"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0061515","properties":[{"key":"GoTerm","value":"P:myeloid cell development"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"7684005"}]},{"database":"GO","id":"GO:0042130","properties":[{"key":"GoTerm","value":"P:negative regulation of T cell proliferation"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0000122","properties":[{"key":"GoTerm","value":"P:negative regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"PubMed","id":"15308669"}]},{"database":"GO","id":"GO:0001541","properties":[{"key":"GoTerm","value":"P:ovarian follicle development"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0070169","properties":[{"key":"GoTerm","value":"P:positive regulation of biomineral tissue development"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"27812542"}]},{"database":"GO","id":"GO:0120162","properties":[{"key":"GoTerm","value":"P:positive regulation of cold-induced thermogenesis"},{"key":"GoEvidenceType","value":"ISS:YuBioLab"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"PubMed","id":"15762841"}]},{"database":"GO","id":"GO:0045893","properties":[{"key":"GoTerm","value":"P:positive regulation of DNA-templated transcription"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"27812542"}]},{"database":"GO","id":"GO:0045600","properties":[{"key":"GoTerm","value":"P:positive regulation of fat cell differentiation"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0050729","properties":[{"key":"GoTerm","value":"P:positive regulation of inflammatory response"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0032753","properties":[{"key":"GoTerm","value":"P:positive regulation of interleukin-4 production"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:2000120","properties":[{"key":"GoTerm","value":"P:positive regulation of sodium-dependent phosphate transport"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"27812542"}]},{"database":"GO","id":"GO:0045944","properties":[{"key":"GoTerm","value":"P:positive regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"IDA:ParkinsonsUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15775988"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"7959007"}]},{"database":"GO","id":"GO:0045595","properties":[{"key":"GoTerm","value":"P:regulation of cell differentiation"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:2001198","properties":[{"key":"GoTerm","value":"P:regulation of dendritic cell differentiation"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0006355","properties":[{"key":"GoTerm","value":"P:regulation of DNA-templated transcription"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20829347"}]},{"database":"GO","id":"GO:1901329","properties":[{"key":"GoTerm","value":"P:regulation of odontoblast differentiation"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"PubMed","id":"15308669"}]},{"database":"GO","id":"GO:0045670","properties":[{"key":"GoTerm","value":"P:regulation of osteoclast differentiation"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0006357","properties":[{"key":"GoTerm","value":"P:regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"IDA:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18647749"}]},{"database":"GO","id":"GO:0034976","properties":[{"key":"GoTerm","value":"P:response to endoplasmic reticulum stress"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20829347"}]},{"database":"GO","id":"GO:0035711","properties":[{"key":"GoTerm","value":"P:T-helper 1 cell activation"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"CDD","id":"cd14712","properties":[{"key":"EntryName","value":"bZIP_CEBPB"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.5.170:FF:000028","properties":[{"key":"EntryName","value":"CCAAT/enhancer-binding protein beta"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.5.170","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR004827","properties":[{"key":"EntryName","value":"bZIP"}]},{"database":"InterPro","id":"IPR046347","properties":[{"key":"EntryName","value":"bZIP_sf"}]},{"database":"InterPro","id":"IPR031106","properties":[{"key":"EntryName","value":"C/EBP"}]},{"database":"InterPro","id":"IPR016468","properties":[{"key":"EntryName","value":"C/EBP_chordates"}]},{"database":"PANTHER","id":"PTHR23334","properties":[{"key":"EntryName","value":"CCAAT/ENHANCER BINDING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR23334:SF21","properties":[{"key":"EntryName","value":"CCAAT_ENHANCER-BINDING PROTEIN BETA"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07716","properties":[{"key":"EntryName","value":"bZIP_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PIRSF","id":"PIRSF005879","properties":[{"key":"EntryName","value":"CCAAT/enhancer-binding"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01217","properties":[{"key":"EntryName","value":"PRICHEXTENSN"}]},{"database":"SMART","id":"SM00338","properties":[{"key":"EntryName","value":"BRLZ"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57959","properties":[{"key":"EntryName","value":"Leucine zipper domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50217","properties":[{"key":"EntryName","value":"BZIP"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MQRLVAWDPACLPLPPPPPAFKSMEVANFYYEADCLAAAYGGKAAPAAPPAARPGPRPPAGELGSIGDHERAIDFSPYLEPLGAPQAPAPATATDTFEAAPPAPAPAPASSGQHHDFLSDLFSDDYGGKNCKKPAEYGYVSLGRLGAAKGALHPGCFAPLHPPPPPPPPPAELKAEPGFEPADCKRKEEAGAPGGGAGMAAGFPYALRAYLGYQAVPSGSSGSLSTSSSSSPPGTPSPADAKAPPTACYAGAAPAPSQVKSKAKKTVDKHSDEYKIRRERNNIAVRKSRDKAKMRNLETQHKVLELTAENERLQKKVEQLSRELSTLRNLFKQLPEPLLASSGHC","length":345,"molWeight":36106,"crc64":"9B725BD6CCAA771D","md5":"06692852B2575AE4AB004AAA4DF4849B"},"extraAttributes":{"countByCommentType":{"FUNCTION":3,"SUBUNIT":1,"INTERACTION":16,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":3,"TISSUE SPECIFICITY":1,"INDUCTION":1,"DOMAIN":1,"PTM":6,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Domain":1,"Region":8,"Motif":1,"Compositional bias":4,"Modified residue":12,"Glycosylation":2,"Cross-link":8,"Alternative sequence":2,"Natural variant":1,"Mutagenesis":2,"Sequence conflict":2,"Beta strand":1,"Helix":1,"Turn":1},"uniParcId":"UPI000000D8BA"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q9BSC0","uniProtkbId":"Q9BSC0_HUMAN","entryAudit":{"firstPublicDate":"2001-06-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2004-03-01","entryVersion":126,"sequenceVersion":2},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAH05132.2"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAH05132.2"}],"value":"CEBPB protein"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAH05132.2"}],"value":"CEBPB"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004123"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00978"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00006951"}],"value":"Belongs to the bZIP family. C/EBP subfamily"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":63,"modifier":"EXACT"},"end":{"value":126,"modifier":"EXACT"}},"description":"BZIP","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50217"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":66,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":86,"modifier":"EXACT"},"end":{"value":122,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Compositional bias","location":{"start":{"value":9,"modifier":"EXACT"},"end":{"value":24,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":57,"modifier":"EXACT"},"end":{"value":66,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAH05132.2"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023159"}],"id":"KW-0010","category":"Molecular function","name":"Activator"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023125"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00978"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00978"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023163"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00978"}],"id":"KW-0804","category":"Biological process","name":"Transcription"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023015"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00978"}],"id":"KW-0805","category":"Biological process","name":"Transcription regulation"}],"references":[{"referenceNumber":1,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"authors":["Gerhard D.S.","Wagner L.","Feingold E.A.","Shenmen C.M.","Grouse L.H.","Schuler G.","Klein S.L.","Old S.","Rasooly R.","Good P.","Guyer M.","Peck A.M.","Derge J.G.","Lipman D.","Collins F.S.","Jang W.","Sherry S.","Feolo M.","Misquitta L.","Lee E.","Rotmistrovsky K.","Greenhut S.F.","Schaefer C.F.","Buetow K.","Bonner T.I.","Haussler D.","Kent J.","Kiekhaus M.","Furey T.","Brent M.","Prange C.","Schreiber K.","Shapiro N.","Bhat N.K.","Hopkins R.F.","Hsie F.","Driscoll T.","Soares M.B.","Casavant T.L.","Scheetz T.E.","Brown-stein M.J.","Usdin T.B.","Toshiyuki S.","Carninci P.","Piao Y.","Dudekula D.B.","Ko M.S.","Kawakami K.","Suzuki Y.","Sugano S.","Gruber C.E.","Smith M.R.","Simmons B.","Moore T.","Waterman R.","Johnson S.L.","Ruan Y.","Wei C.L.","Mathavan S.","Gunaratne P.H.","Wu J.","Garcia A.M.","Hulyk S.W.","Fuh E.","Yuan Y.","Sneed A.","Kowis C.","Hodgson A.","Muzny D.M.","McPherson J.","Gibbs R.A.","Fahey J.","Helton E.","Ketteman M.","Madan A.","Rodrigues S.","Sanchez A.","Whiting M.","Madari A.","Young A.C.","Wetherby K.D.","Granite S.J.","Kwong P.N.","Brinkley C.P.","Pearson R.L.","Bouffard G.G.","Blakesly R.W.","Green E.D.","Dickson M.C.","Rodriguez A.C.","Grimwood J.","Schmutz J.","Myers R.M.","Butterfield Y.S.","Griffith M.","Griffith O.L.","Krzywinski M.I.","Liao N.","Morin R.","Morrin R.","Palmquist D.","Petrescu A.S.","Skalska U.","Smailus D.E.","Stott J.M.","Schnerch A.","Schein J.E.","Jones S.J.","Holt R.A.","Baross A.","Marra M.A.","Clifton S.","Makowski K.A.","Bosak S.","Malek J."],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAH05132.2"}],"value":"Ovary","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAH05132.2"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"BC005132","properties":[{"key":"ProteinId","value":"AAH05132.2"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"PIR","id":"S66246","properties":[{"key":"EntryName","value":"S66246"}]},{"database":"AlphaFoldDB","id":"Q9BSC0","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q9BSC0","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q9BSC0","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"10032067at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"CEBPB","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GO","id":"GO:0090575","properties":[{"key":"GoTerm","value":"C:RNA polymerase II transcription regulator complex"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0003700","properties":[{"key":"GoTerm","value":"F:DNA-binding transcription factor activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006351","properties":[{"key":"GoTerm","value":"P:DNA-templated transcription"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd14712","properties":[{"key":"EntryName","value":"bZIP_CEBPB"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.5.170:FF:000028","properties":[{"key":"EntryName","value":"CCAAT/enhancer-binding protein beta"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.5.170","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR004827","properties":[{"key":"EntryName","value":"bZIP"}]},{"database":"InterPro","id":"IPR046347","properties":[{"key":"EntryName","value":"bZIP_sf"}]},{"database":"InterPro","id":"IPR031106","properties":[{"key":"EntryName","value":"C/EBP"}]},{"database":"PANTHER","id":"PTHR23334","properties":[{"key":"EntryName","value":"CCAAT/ENHANCER BINDING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR23334:SF21","properties":[{"key":"EntryName","value":"CCAAT_ENHANCER-BINDING PROTEIN BETA"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07716","properties":[{"key":"EntryName","value":"bZIP_2"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00338","properties":[{"key":"EntryName","value":"BRLZ"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57959","properties":[{"key":"EntryName","value":"Leucine zipper domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50217","properties":[{"key":"EntryName","value":"BZIP"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"AYLGYQAVPSGSSGSLSTSSSSSPPGTPSPADAKAPPTACYAGAAPAPSQVKSKAKKTVDKHSDEYKIRRERNNIAVRKSRDKAKMRNLETQHKVLELTAENERLQKKVEQLSRELSTLRNLFKQLPEPLLASSGHC","length":137,"molWeight":14860,"crc64":"86108F55B335242A","md5":"F48C96CC3549A0844D19B35C9688AC3E"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Domain":1,"Region":1,"Coiled coil":1,"Compositional bias":2,"Non-terminal residue":1},"uniParcId":"UPI0000227D74"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"W8SNU6","uniProtkbId":"W8SNU6_HUMAN","entryAudit":{"firstPublicDate":"2014-05-14","lastAnnotationUpdateDate":"2025-04-02","lastSequenceUpdateDate":"2014-05-14","entryVersion":26,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AHM26745.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AHM26745.1"}],"value":"Transcription factor C/EBP beta"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AHM26745.1"}],"value":"CEBPB"}}],"features":[{"type":"Region","location":{"start":{"value":35,"modifier":"EXACT"},"end":{"value":92,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":38,"modifier":"EXACT"},"end":{"value":50,"modifier":"EXACT"}},"description":"Pro residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":71,"modifier":"EXACT"},"end":{"value":86,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AHM26745.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":92,"modifier":"EXACT"},"end":{"value":92,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AHM26745.1"}]}],"references":[{"referenceNumber":1,"citation":{"id":"CI-21AL9QQAHSD23","citationType":"submission","authors":["Mahatme P.","Apte I.","Kotwal S."],"title":"Identification of probable C/EBP-beta activation domain polymorphism in Indian women diagnosed with PCOS and NAFLD.","publicationDate":"JAN-2014","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AHM26745.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KJ161467","properties":[{"key":"ProteinId","value":"AHM26744.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"KJ161468","properties":[{"key":"ProteinId","value":"AHM26745.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"KJ161469","properties":[{"key":"ProteinId","value":"AHM26746.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"W8SNU6","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"W8SNU6","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"10032067at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"CEBPB","properties":[{"key":"OrganismName","value":"human"}]}],"sequence":{"value":"ACLPLPPPPPAFKSMEVANFYYEADCLAAAYGGKAAPAAPPAARPGPRPPAGELGSIGDHERAIDFSPYLEPLGAPQAPAPATATDTFEEAP","length":92,"molWeight":9372,"crc64":"DB20C23302CE179E","md5":"5E49A7E317C17161DA234507E444AA2A"},"extraAttributes":{"countByFeatureType":{"Region":1,"Compositional bias":2,"Non-terminal residue":2},"uniParcId":"UPI00042E9BFC"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"W8SNV5","uniProtkbId":"W8SNV5_HUMAN","entryAudit":{"firstPublicDate":"2014-05-14","lastAnnotationUpdateDate":"2025-04-02","lastSequenceUpdateDate":"2014-05-14","entryVersion":29,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AHM26755.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AHM26755.1"}],"value":"Transcription factor C/EBP beta"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AHM26755.1"}],"value":"CEBPB"}}],"features":[{"type":"Region","location":{"start":{"value":35,"modifier":"EXACT"},"end":{"value":92,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":38,"modifier":"EXACT"},"end":{"value":50,"modifier":"EXACT"}},"description":"Pro residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":75,"modifier":"EXACT"},"end":{"value":92,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AHM26755.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":92,"modifier":"EXACT"},"end":{"value":92,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AHM26755.1"}]}],"references":[{"referenceNumber":1,"citation":{"id":"CI-21AL9QQAHSD23","citationType":"submission","authors":["Mahatme P.","Apte I.","Kotwal S."],"title":"Identification of probable C/EBP-beta activation domain polymorphism in Indian women diagnosed with PCOS and NAFLD.","publicationDate":"JAN-2014","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AHM26755.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KJ161450","properties":[{"key":"ProteinId","value":"AHM26727.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"KJ161451","properties":[{"key":"ProteinId","value":"AHM26728.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"KJ161452","properties":[{"key":"ProteinId","value":"AHM26729.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"KJ161453","properties":[{"key":"ProteinId","value":"AHM26730.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"KJ161454","properties":[{"key":"ProteinId","value":"AHM26731.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"KJ161455","properties":[{"key":"ProteinId","value":"AHM26732.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"KJ161456","properties":[{"key":"ProteinId","value":"AHM26733.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"KJ161457","properties":[{"key":"ProteinId","value":"AHM26734.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"KJ161458","properties":[{"key":"ProteinId","value":"AHM26735.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"KJ161459","properties":[{"key":"ProteinId","value":"AHM26736.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"KJ161460","properties":[{"key":"ProteinId","value":"AHM26737.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"KJ161461","properties":[{"key":"ProteinId","value":"AHM26738.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"KJ161462","properties":[{"key":"ProteinId","value":"AHM26739.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"KJ161463","properties":[{"key":"ProteinId","value":"AHM26740.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"KJ161464","properties":[{"key":"ProteinId","value":"AHM26741.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"KJ161465","properties":[{"key":"ProteinId","value":"AHM26742.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"KJ161466","properties":[{"key":"ProteinId","value":"AHM26743.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"KJ161470","properties":[{"key":"ProteinId","value":"AHM26747.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"KJ161471","properties":[{"key":"ProteinId","value":"AHM26748.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"KJ161472","properties":[{"key":"ProteinId","value":"AHM26749.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"KJ161473","properties":[{"key":"ProteinId","value":"AHM26750.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"KJ161474","properties":[{"key":"ProteinId","value":"AHM26751.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"KJ161475","properties":[{"key":"ProteinId","value":"AHM26752.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"KJ161476","properties":[{"key":"ProteinId","value":"AHM26753.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"KJ161477","properties":[{"key":"ProteinId","value":"AHM26754.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"KJ161478","properties":[{"key":"ProteinId","value":"AHM26755.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"KJ161479","properties":[{"key":"ProteinId","value":"AHM26756.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"KJ161480","properties":[{"key":"ProteinId","value":"AHM26757.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"KJ161481","properties":[{"key":"ProteinId","value":"AHM26758.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"W8SNV5","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"W8SNV5","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"10032067at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"CEBPB","properties":[{"key":"OrganismName","value":"human"}]}],"sequence":{"value":"ACLPLPPPPPAFKSMEVANFYYEADCLAAAYGGKAAPAAPPAARPGPRPPAGELGSIGDHERAIDFSPYLEPLGAPQAPAPATATDTFEAAP","length":92,"molWeight":9314,"crc64":"DB20C4F302CE179E","md5":"5AC359D7A69A74E56C64981ACED6D528"},"extraAttributes":{"countByFeatureType":{"Region":1,"Compositional bias":2,"Non-terminal residue":2},"uniParcId":"UPI00042F26CA"}}]}