{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P55287","secondaryAccessions":["A8K5D6","A8MZC8","B7WP28","Q15065","Q15066","Q9UQ93","Q9UQ94"],"uniProtkbId":"CAD11_HUMAN","entryAudit":{"firstPublicDate":"1996-10-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2007-05-01","entryVersion":198,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Cadherin-11"}},"alternativeNames":[{"fullName":{"value":"OSF-4"}},{"fullName":{"value":"Osteoblast cadherin"},"shortNames":[{"value":"OB-cadherin"}]}],"flag":"Precursor"},"genes":[{"geneName":{"value":"CDH11"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33811546"}],"value":"Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Required for proper focal adhesion assembly (PubMed:33811546). Involved in the regulation of cell migration (PubMed:33811546)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Interacts with PCDH8"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"value":"Cell membrane","id":"SL-0039"},"topology":{"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["P55287-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["P55287-2"],"sequenceIds":["VSP_000640","VSP_000641"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33811546"}],"value":"Expressed mainly in brain but also found in other tissues. Expressed in neuroblasts. In the embryo from 67 to 72 days of gestation, detected at high levels in facial mesenchyme including the central palatal mesenchyme, dental mesenchyme, the eye and optic muscle, and the tongue (at protein level) (PubMed:33811546)"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain"}],"commentType":"DOMAIN"},{"commentType":"DISEASE","note":{"texts":[{"value":"A chromosomal aberration involving CDH11 is a common genetic feature of aneurysmal bone cyst, a benign osseous neoplasm. Translocation t(16;17)(q22;p13) with USP6. The translocation generates a fusion gene in which the strong CDH11 promoter is fused to the entire USP6 coding sequence, resulting in USP6 transcriptional up-regulation"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"Elsahy-Waters syndrome","diseaseAccession":"DI-05231","acronym":"ESWS","description":"An autosomal recessive syndrome characterized by moderate intellectual disability, hypospadias and characteristic craniofacial morphology, which includes brachycephaly, facial asymmetry, exotropia, hypertelorism, telechantus, broad nose, concave nasal ridge, underdeveloped mid-face, prognathism, and radicular dentin dysplasia.","diseaseCrossReference":{"database":"MIM","id":"211380"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28988429"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29271567"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"Teebi hypertelorism syndrome 2","diseaseAccession":"DI-06331","acronym":"TBHS2","description":"A form of Teebi hypertelorism syndrome, a syndrome characterized by an abnormally increased distance between ocular orbits, and facial features that can resemble craniofrontonasal dysplasia such as prominent forehead, widow's peak, heavy and broad eyebrows, long palpebral fissures, ptosis, high and broad nasal bridge, short nose, low-set ears, natal teeth, thin upper lip and a grooved chin. Some affected individuals have limb, urogenital, umbilical and cardiac defects. Developmental delay and/or impaired intellectual development have been observed in some patients. TBHS2 inheritance is autosomal dominant.","diseaseCrossReference":{"database":"MIM","id":"619736"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33811546"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Propeptide","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":53,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":"PRO_0000003785"},{"type":"Chain","location":{"start":{"value":54,"modifier":"EXACT"},"end":{"value":796,"modifier":"EXACT"}},"description":"Cadherin-11","featureId":"PRO_0000003786"},{"type":"Topological domain","location":{"start":{"value":54,"modifier":"EXACT"},"end":{"value":617,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":618,"modifier":"EXACT"},"end":{"value":640,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":641,"modifier":"EXACT"},"end":{"value":796,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Domain","location":{"start":{"value":54,"modifier":"EXACT"},"end":{"value":159,"modifier":"EXACT"}},"description":"Cadherin 1","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00043"}]},{"type":"Domain","location":{"start":{"value":160,"modifier":"EXACT"},"end":{"value":268,"modifier":"EXACT"}},"description":"Cadherin 2","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00043"}]},{"type":"Domain","location":{"start":{"value":269,"modifier":"EXACT"},"end":{"value":383,"modifier":"EXACT"}},"description":"Cadherin 3","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00043"}]},{"type":"Domain","location":{"start":{"value":384,"modifier":"EXACT"},"end":{"value":486,"modifier":"EXACT"}},"description":"Cadherin 4","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00043"}]},{"type":"Domain","location":{"start":{"value":487,"modifier":"EXACT"},"end":{"value":612,"modifier":"EXACT"}},"description":"Cadherin 5","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00043"}]},{"type":"Modified residue","location":{"start":{"value":788,"modifier":"EXACT"},"end":{"value":788,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P55288"}]},{"type":"Modified residue","location":{"start":{"value":791,"modifier":"EXACT"},"end":{"value":791,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P55288"}]},{"type":"Glycosylation","location":{"start":{"value":455,"modifier":"EXACT"},"end":{"value":455,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":540,"modifier":"EXACT"},"end":{"value":540,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Alternative sequence","location":{"start":{"value":632,"modifier":"EXACT"},"end":{"value":693,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"8163513"}],"featureId":"VSP_000640","alternativeSequence":{"originalSequence":"VIVVLFVTLRRQKKEPLIVFEEEDVRENIITYDDEGGGEEDTEAFDIATLQNPDGINGFIPR","alternativeSequences":["GCPSLMEPPSPREDMRLLYLGFQLMLFSYVKVNRRFCLLGVFIKLPFLYVVATESPTTLTSL"]}},{"type":"Alternative sequence","location":{"start":{"value":694,"modifier":"EXACT"},"end":{"value":796,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"8163513"}],"featureId":"VSP_000641","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":55,"modifier":"EXACT"},"end":{"value":55,"modifier":"EXACT"}},"description":"in TBHS2; results in loss of cell adhesion as shown by a cell-substrate adhesion assay; dbSNP:rs2142528709","featureCrossReferences":[{"database":"dbSNP","id":"rs2142528709"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33811546"}],"featureId":"VAR_086894","alternativeSequence":{"originalSequence":"W","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":140,"modifier":"EXACT"},"end":{"value":140,"modifier":"EXACT"}},"description":"in TBHS2; results in loss of cell adhesion as shown by a cell-substrate adhesion assay","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33811546"}],"featureId":"VAR_086895","alternativeSequence":{"originalSequence":"E","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":232,"modifier":"EXACT"},"end":{"value":796,"modifier":"EXACT"}},"description":"in ESWS","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29271567"}],"featureId":"VAR_080481","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":255,"modifier":"EXACT"},"end":{"value":255,"modifier":"EXACT"}},"description":"in dbSNP:rs35195","featureCrossReferences":[{"database":"dbSNP","id":"rs35195"}],"featureId":"VAR_031945","alternativeSequence":{"originalSequence":"T","alternativeSequences":["M"]}},{"type":"Natural variant","location":{"start":{"value":260,"modifier":"EXACT"},"end":{"value":260,"modifier":"EXACT"}},"description":"in TBHS2; dbSNP:rs1000294766","featureCrossReferences":[{"database":"dbSNP","id":"rs1000294766"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33811546"}],"featureId":"VAR_086896","alternativeSequence":{"originalSequence":"D","alternativeSequences":["E"]}},{"type":"Natural variant","location":{"start":{"value":260,"modifier":"EXACT"},"end":{"value":260,"modifier":"EXACT"}},"description":"in TBHS2; results in decreased cell adhesion as shown by a cell-substrate adhesion assay; dbSNP:rs2142492118","featureCrossReferences":[{"database":"dbSNP","id":"rs2142492118"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33811546"}],"featureId":"VAR_086897","alternativeSequence":{"originalSequence":"D","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":262,"modifier":"EXACT"},"end":{"value":262,"modifier":"EXACT"}},"description":"in TBHS2; results in decreased cell adhesion as shown by a cell-substrate adhesion assay","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33811546"}],"featureId":"VAR_086898","alternativeSequence":{"originalSequence":"N","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":266,"modifier":"EXACT"},"end":{"value":266,"modifier":"EXACT"}},"description":"in TBHS2; dbSNP:rs1426094439","featureCrossReferences":[{"database":"dbSNP","id":"rs1426094439"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33811546"}],"featureId":"VAR_086899","alternativeSequence":{"originalSequence":"P","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":275,"modifier":"EXACT"},"end":{"value":275,"modifier":"EXACT"}},"description":"in dbSNP:rs1130821","featureCrossReferences":[{"database":"dbSNP","id":"rs1130821"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8163513"}],"featureId":"VAR_031946","alternativeSequence":{"originalSequence":"M","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":279,"modifier":"EXACT"},"end":{"value":279,"modifier":"EXACT"}},"description":"in TBHS2; results in increased cell migration as shown by an in vitro wound closure assay using patient cells; dbSNP:rs2142481275","featureCrossReferences":[{"database":"dbSNP","id":"rs2142481275"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33811546"}],"featureId":"VAR_086900","alternativeSequence":{"originalSequence":"E","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":327,"modifier":"EXACT"},"end":{"value":327,"modifier":"EXACT"}},"description":"in TBHS2; results in loss of cell adhesion as shown by a cell-substrate adhesion assay; dbSNP:rs2142480699","featureCrossReferences":[{"database":"dbSNP","id":"rs2142480699"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33811546"}],"featureId":"VAR_086901","alternativeSequence":{"originalSequence":"G","alternativeSequences":["W"]}},{"type":"Natural variant","location":{"start":{"value":373,"modifier":"EXACT"},"end":{"value":373,"modifier":"EXACT"}},"description":"in dbSNP:rs35213","featureCrossReferences":[{"database":"dbSNP","id":"rs35213"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14702039"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8163513"}],"featureId":"VAR_031947","alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":374,"modifier":"EXACT"},"end":{"value":374,"modifier":"EXACT"}},"description":"in TBHS2; dbSNP:rs2142459670","featureCrossReferences":[{"database":"dbSNP","id":"rs2142459670"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33811546"}],"featureId":"VAR_086902","alternativeSequence":{"originalSequence":"V","alternativeSequences":["E"]}},{"type":"Sequence conflict","location":{"start":{"value":271,"modifier":"EXACT"},"end":{"value":272,"modifier":"EXACT"}},"description":"in Ref. 1; AAA35622 and 5; no nucleotide entry","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"SV","alternativeSequences":["RL"]}},{"type":"Sequence conflict","location":{"start":{"value":340,"modifier":"EXACT"},"end":{"value":340,"modifier":"EXACT"}},"description":"in Ref. 1; AAA35622 and 5; no nucleotide entry","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["E"]}},{"type":"Sequence conflict","location":{"start":{"value":471,"modifier":"EXACT"},"end":{"value":471,"modifier":"EXACT"}},"description":"in Ref. 1; AAA35622 and 5; no nucleotide entry","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["Q"]}}],"keywords":[{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0106","category":"Ligand","name":"Calcium"},{"id":"KW-0130","category":"Biological process","name":"Cell adhesion"},{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-0160","category":"Coding sequence diversity","name":"Chromosomal rearrangement"},{"id":"KW-0165","category":"PTM","name":"Cleavage on pair of basic residues"},{"id":"KW-0209","category":"Disease","name":"Deafness"},{"id":"KW-0225","category":"Disease","name":"Disease variant"},{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-0991","category":"Disease","name":"Intellectual disability"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0677","category":"Domain","name":"Repeat"},{"id":"KW-0732","category":"Domain","name":"Signal"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"7982033","citationType":"journal article","authors":["Tanihara H.","Sano K.","Heimark R.L.","St John T.","Suzuki S."],"citationCrossReferences":[{"database":"PubMed","id":"7982033"},{"database":"DOI","id":"10.3109/15419069409014199"}],"title":"Cloning of five human cadherins clarifies characteristic features of cadherin extracellular domain and provides further evidence for two structurally different types of cadherin.","publicationDate":"1994","journal":"Cell Adhes. Commun.","firstPage":"15","lastPage":"26","volume":"2"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"8163513","citationType":"journal article","authors":["Okazaki M.","Takeshita S.","Kawai S.","Kikuno R.","Tsujimura A.","Kudo A.","Amann E."],"citationCrossReferences":[{"database":"PubMed","id":"8163513"},{"database":"DOI","id":"10.1016/s0021-9258(17)32685-6"}],"title":"Molecular cloning and characterization of OB-cadherin, a new member of cadherin family expressed in osteoblasts.","publicationDate":"1994","journal":"J. Biol. Chem.","firstPage":"12092","lastPage":"12098","volume":"269"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)","VARIANTS ILE-275 AND ALA-373"],"referenceComments":[{"value":"Osteosarcoma","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)","VARIANT ALA-373"]},{"referenceNumber":4,"citation":{"id":"15616553","citationType":"journal article","authors":["Martin J.","Han C.","Gordon L.A.","Terry A.","Prabhakar S.","She X.","Xie G.","Hellsten U.","Chan Y.M.","Altherr M.","Couronne O.","Aerts A.","Bajorek E.","Black S.","Blumer H.","Branscomb E.","Brown N.C.","Bruno W.J.","Buckingham J.M.","Callen D.F.","Campbell C.S.","Campbell M.L.","Campbell E.W.","Caoile C.","Challacombe J.F.","Chasteen L.A.","Chertkov O.","Chi H.C.","Christensen M.","Clark L.M.","Cohn J.D.","Denys M.","Detter J.C.","Dickson M.","Dimitrijevic-Bussod M.","Escobar J.","Fawcett J.J.","Flowers D.","Fotopulos D.","Glavina T.","Gomez M.","Gonzales E.","Goodstein D.","Goodwin L.A.","Grady D.L.","Grigoriev I.","Groza M.","Hammon N.","Hawkins T.","Haydu L.","Hildebrand C.E.","Huang W.","Israni S.","Jett J.","Jewett P.B.","Kadner K.","Kimball H.","Kobayashi A.","Krawczyk M.-C.","Leyba T.","Longmire J.L.","Lopez F.","Lou Y.","Lowry S.","Ludeman T.","Manohar C.F.","Mark G.A.","McMurray K.L.","Meincke L.J.","Morgan J.","Moyzis R.K.","Mundt M.O.","Munk A.C.","Nandkeshwar R.D.","Pitluck S.","Pollard M.","Predki P.","Parson-Quintana B.","Ramirez L.","Rash S.","Retterer J.","Ricke D.O.","Robinson D.L.","Rodriguez A.","Salamov A.","Saunders E.H.","Scott D.","Shough T.","Stallings R.L.","Stalvey M.","Sutherland R.D.","Tapia R.","Tesmer J.G.","Thayer N.","Thompson L.S.","Tice H.","Torney D.C.","Tran-Gyamfi M.","Tsai M.","Ulanovsky L.E.","Ustaszewska A.","Vo N.","White P.S.","Williams A.L.","Wills P.L.","Wu J.-R.","Wu K.","Yang J.","DeJong P.","Bruce D.","Doggett N.A.","Deaven L.","Schmutz J.","Grimwood J.","Richardson P.","Rokhsar D.S.","Eichler E.E.","Gilna P.","Lucas S.M.","Myers R.M.","Rubin E.M.","Pennacchio L.A."],"citationCrossReferences":[{"database":"PubMed","id":"15616553"},{"database":"DOI","id":"10.1038/nature03187"}],"title":"The sequence and analysis of duplication-rich human chromosome 16.","publicationDate":"2004","journal":"Nature","firstPage":"988","lastPage":"994","volume":"432"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":5,"citation":{"id":"2059658","citationType":"journal article","authors":["Suzuki S.","Sano K.","Tanihara H."],"citationCrossReferences":[{"database":"PubMed","id":"2059658"},{"database":"DOI","id":"10.1091/mbc.2.4.261"}],"title":"Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue.","publicationDate":"1991","journal":"Cell Regul.","firstPage":"261","lastPage":"270","volume":"2"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF 269-796 (ISOFORM 1)"],"referenceComments":[{"value":"Fetal brain","type":"TISSUE"}]},{"referenceNumber":6,"citation":{"id":"CI-AP05QP5KB195","citationType":"submission","authors":["Kools P.F.J.","Hogendoorn P.C.W.","Bovee J.V.M.G.","van Roy F."],"title":"Alternative cadherin-11 transcripts encoding truncated adhesion molecules are detectable in both human cancer and normal cells.","publicationDate":"APR-1998","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 600-668"]},{"referenceNumber":7,"citation":{"id":"15026324","citationType":"journal article","authors":["Oliveira A.M.","Hsi B.L.","Weremowicz S.","Rosenberg A.E.","Dal Cin P.","Joseph N.","Bridge J.A.","Perez-Atayde A.R.","Fletcher J.A."],"citationCrossReferences":[{"database":"PubMed","id":"15026324"},{"database":"DOI","id":"10.1158/0008-5472.can-03-2827"}],"title":"USP6 (Tre2) fusion oncogenes in aneurysmal bone cyst.","publicationDate":"2004","journal":"Cancer Res.","firstPage":"1920","lastPage":"1923","volume":"64"},"referencePositions":["CHROMOSOMAL TRANSLOCATION WITH USP6"]},{"referenceNumber":8,"citation":{"id":"28988429","citationType":"journal article","authors":["Taskiran E.Z.","Karaosmanoglu B.","Kosukcu C.","Dogan O.A.","Taylan-Sekeroglu H.","Simsek-Kiper P.O.","Utine E.G.","Boduroglu K.","Alikasifoglu M."],"citationCrossReferences":[{"database":"PubMed","id":"28988429"},{"database":"DOI","id":"10.1002/ajmg.a.38495"}],"title":"Homozygous indel mutation in CDH11 as the probable cause of Elsahy-Waters syndrome.","publicationDate":"2017","journal":"Am. J. Med. Genet. A","firstPage":"3143","lastPage":"3152","volume":"173"},"referencePositions":["INVOLVEMENT IN ESWS"]},{"referenceNumber":9,"citation":{"id":"29271567","citationType":"journal article","authors":["Harms F.L.","Nampoothiri S.","Anazi S.","Yesodharan D.","Alawi M.","Kutsche K.","Alkuraya F.S."],"citationCrossReferences":[{"database":"PubMed","id":"29271567"},{"database":"DOI","id":"10.1002/ajmg.a.38568"}],"title":"Elsahy-Waters syndrome is caused by biallelic mutations in CDH11.","publicationDate":"2018","journal":"Am. J. Med. Genet. A","firstPage":"477","lastPage":"482","volume":"176"},"referencePositions":["INVOLVEMENT IN ESWS","VARIANT ESWS 232-TYR--SER-796 DEL"]},{"referenceNumber":10,"citation":{"id":"33811546","citationType":"journal article","authors":["Li D.","March M.E.","Fortugno P.","Cox L.L.","Matsuoka L.S.","Monetta R.","Seiler C.","Pyle L.C.","Bedoukian E.C.","Sanchez-Soler M.J.","Caluseriu O.","Grand K.","Tam A.","Aycinena A.R.P.","Camerota L.","Guo Y.","Sleiman P.","Callewaert B.","Kumps C.","Dheedene A.","Buckley M.","Kirk E.P.","Turner A.","Kamien B.","Patel C.","Wilson M.","Roscioli T.","Christodoulou J.","Cox T.C.","Zackai E.H.","Brancati F.","Hakonarson H.","Bhoj E.J."],"citationCrossReferences":[{"database":"PubMed","id":"33811546"},{"database":"DOI","id":"10.1007/s00439-021-02274-3"}],"title":"Pathogenic variants in CDH11 impair cell adhesion and cause Teebi hypertelorism syndrome.","publicationDate":"2021","journal":"Hum. Genet.","firstPage":"1061","lastPage":"1076","volume":"140"},"referencePositions":["VARIANTS TBHS2 SER-55; LYS-140; ASN-260; GLU-260; ILE-262; LEU-266; GLN-279; TRP-327 AND GLU-374","INVOLVEMENT IN TBHS2","CHARACTERIZATION OF VARIANTS TBHS2 SER-55; LYS-140; ASN-260; ILE-262; GLN-279 AND TRP-327","FUNCTION","TISSUE SPECIFICITY"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"L34056","properties":[{"key":"ProteinId","value":"AAA35622.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"D21254","properties":[{"key":"ProteinId","value":"BAA04798.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"D21255","properties":[{"key":"ProteinId","value":"BAA04799.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK291251","properties":[{"key":"ProteinId","value":"BAF83940.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AC010533","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF060370","properties":[{"key":"ProteinId","value":"AAD27755.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF060369","properties":[{"key":"ProteinId","value":"AAD27755.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF060370","properties":[{"key":"ProteinId","value":"AAD27756.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF060369","properties":[{"key":"ProteinId","value":"AAD27756.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"CCDS","id":"CCDS10803.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P55287-1"},{"database":"CCDS","id":"CCDS81993.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P55287-2"},{"database":"PIR","id":"A38992","properties":[{"key":"EntryName","value":"A38992"}]},{"database":"RefSeq","id":"NP_001295321.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001308392.2"}],"isoformId":"P55287-2"},{"database":"RefSeq","id":"NP_001788.2","properties":[{"key":"NucleotideSequenceId","value":"NM_001797.4"}],"isoformId":"P55287-1"},{"database":"RefSeq","id":"XP_054235325.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054379350.1"}],"isoformId":"P55287-1"},{"database":"RefSeq","id":"XP_054235326.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054379351.1"}],"isoformId":"P55287-2"},{"database":"AlphaFoldDB","id":"P55287","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P55287","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"107444","properties":[{"key":"Interactions","value":"13"}]},{"database":"CORUM","id":"P55287","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P55287","properties":[{"key":"Number of interactors","value":"360"}]},{"database":"IntAct","id":"P55287","properties":[{"key":"Interactions","value":"23"}]},{"database":"MINT","id":"P55287","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-CDH11","properties":[{"key":"Evidences","value":"8 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000268603","properties":[{"key":"Description","value":"-"}]},{"database":"DrugBank","id":"DB00482","properties":[{"key":"GenericName","value":"Celecoxib"}]},{"database":"GlyCosmos","id":"P55287","properties":[{"key":"glycosylation","value":"2 sites, No reported glycans"}]},{"database":"GlyGen","id":"P55287","properties":[{"key":"glycosylation","value":"5 sites, 3 N-linked glycans (2 sites), 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"P55287","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"P55287","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"CDH11","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"146345381","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"P55287","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"P55287","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000268603","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P55287","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"56837","properties":[{"key":"Description","value":"-"}],"isoformId":"P55287-1"},{"database":"ProteomicsDB","id":"56838","properties":[{"key":"Description","value":"-"}],"isoformId":"P55287-2"},{"database":"ABCD","id":"P55287","properties":[{"key":"antibodies","value":"16 sequenced antibodies"}]},{"database":"Antibodypedia","id":"4584","properties":[{"key":"antibodies","value":"857 antibodies from 40 providers"}]},{"database":"DNASU","id":"1009","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000268603.9","properties":[{"key":"ProteinId","value":"ENSP00000268603.4"},{"key":"GeneId","value":"ENSG00000140937.15"}],"isoformId":"P55287-1"},{"database":"Ensembl","id":"ENST00000394156.7","properties":[{"key":"ProteinId","value":"ENSP00000377711.3"},{"key":"GeneId","value":"ENSG00000140937.15"}],"isoformId":"P55287-2"},{"database":"GeneID","id":"1009","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:1009","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000268603.9","properties":[{"key":"ProteinId","value":"ENSP00000268603.4"},{"key":"RefSeqNucleotideId","value":"NM_001797.4"},{"key":"RefSeqProteinId","value":"NP_001788.2"}]},{"database":"UCSC","id":"uc002eoi.4","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"P55287-1"},{"database":"AGR","id":"HGNC:1750","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA26284","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"1009","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"1009","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"CDH11","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:1750","properties":[{"key":"GeneName","value":"CDH11"}]},{"database":"HPA","id":"ENSG00000140937","properties":[{"key":"ExpressionPatterns","value":"Tissue enhanced (ovary, placenta)"}]},{"database":"MalaCards","id":"CDH11","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"211380","properties":[{"key":"Type","value":"phenotype"}]},{"database":"MIM","id":"600023","properties":[{"key":"Type","value":"gene"}]},{"database":"MIM","id":"619736","properties":[{"key":"Type","value":"phenotype"}]},{"database":"OpenTargets","id":"ENSG00000140937","properties":[{"key":"Description","value":"-"}]},{"database":"Orphanet","id":"1299","properties":[{"key":"Disease","value":"Branchioskeletogenital syndrome"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000140937","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG3594","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000153691","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_005284_4_3_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P55287","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"ERYFVIN","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"8188793at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"P55287","properties":[{"key":"Number of GO annotations","value":"10 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"P55287","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"P55287","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-418990","properties":[{"key":"PathwayName","value":"Adherens junctions interactions"}]},{"database":"Reactome","id":"R-HSA-9759811","properties":[{"key":"PathwayName","value":"Regulation of CDH11 mRNA translation by microRNAs"}],"isoformId":"P55287-2"},{"database":"Reactome","id":"R-HSA-9762292","properties":[{"key":"PathwayName","value":"Regulation of CDH11 function"}],"isoformId":"P55287-2"},{"database":"Reactome","id":"R-HSA-9833576","properties":[{"key":"PathwayName","value":"CDH11 homotypic and heterotypic interactions"}]},{"database":"Reactome","id":"R-HSA-9958810","properties":[{"key":"PathwayName","value":"SRC activates STAT3 in a quantitative manner, through Cadherin-11 (CDH11), RAC1 and gp130 (IL6ST)"}]},{"database":"Reactome","id":"R-HSA-9958825","properties":[{"key":"PathwayName","value":"Activation of STAT3 by cadherin engagement"}]},{"database":"SignaLink","id":"P55287","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"P55287","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000140937","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"1009","properties":[{"key":"hits","value":"16 hits in 1149 CRISPR screens"}]},{"database":"ChiTaRS","id":"CDH11","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GeneWiki","id":"CDH11","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"1009","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"P55287","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:P55287","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 16"}]},{"database":"RNAct","id":"P55287","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000140937","properties":[{"key":"ExpressionPatterns","value":"Expressed in periodontal ligament and 195 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"P55287","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005912","properties":[{"key":"GoTerm","value":"C:adherens junction"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0016342","properties":[{"key":"GoTerm","value":"C:catenin complex"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0070062","properties":[{"key":"GoTerm","value":"C:extracellular exosome"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"23533145"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0098978","properties":[{"key":"GoTerm","value":"C:glutamatergic synapse"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0098685","properties":[{"key":"GoTerm","value":"C:Schaffer collateral - CA1 synapse"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0008013","properties":[{"key":"GoTerm","value":"F:beta-catenin binding"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0045296","properties":[{"key":"GoTerm","value":"F:cadherin binding"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0005509","properties":[{"key":"GoTerm","value":"F:calcium ion binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0034332","properties":[{"key":"GoTerm","value":"P:adherens junction organization"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0003189","properties":[{"key":"GoTerm","value":"P:aortic valve formation"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"PubMed","id":"26188246"}]},{"database":"GO","id":"GO:0016339","properties":[{"key":"GoTerm","value":"P:calcium-dependent cell-cell adhesion"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0007155","properties":[{"key":"GoTerm","value":"P:cell adhesion"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"8163513"}]},{"database":"GO","id":"GO:0016477","properties":[{"key":"GoTerm","value":"P:cell migration"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"PubMed","id":"26188246"}]},{"database":"GO","id":"GO:0000902","properties":[{"key":"GoTerm","value":"P:cell morphogenesis"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0044331","properties":[{"key":"GoTerm","value":"P:cell-cell adhesion mediated by cadherin"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0007043","properties":[{"key":"GoTerm","value":"P:cell-cell junction assembly"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0031589","properties":[{"key":"GoTerm","value":"P:cell-substrate adhesion"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"33811546"}]},{"database":"GO","id":"GO:0048041","properties":[{"key":"GoTerm","value":"P:focal adhesion assembly"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"33811546"}]},{"database":"GO","id":"GO:0007156","properties":[{"key":"GoTerm","value":"P:homophilic cell-cell adhesion"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0050804","properties":[{"key":"GoTerm","value":"P:modulation of chemical synaptic transmission"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0030336","properties":[{"key":"GoTerm","value":"P:negative regulation of cell migration"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"33811546"}]},{"database":"GO","id":"GO:0001503","properties":[{"key":"GoTerm","value":"P:ossification"},{"key":"GoEvidenceType","value":"NAS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"8163513"}]},{"database":"GO","id":"GO:0001501","properties":[{"key":"GoTerm","value":"P:skeletal system development"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"8163513"}]},{"database":"GO","id":"GO:0043588","properties":[{"key":"GoTerm","value":"P:skin development"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"CDD","id":"cd11304","properties":[{"key":"EntryName","value":"Cadherin_repeat"},{"key":"MatchStatus","value":"4"}]},{"database":"FunFam","id":"4.10.900.10:FF:000001","properties":[{"key":"EntryName","value":"Cadherin 2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.60:FF:000008","properties":[{"key":"EntryName","value":"Cadherin 24"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.60:FF:000009","properties":[{"key":"EntryName","value":"Cadherin 24"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.60:FF:000012","properties":[{"key":"EntryName","value":"Cadherin 24"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.60:FF:000017","properties":[{"key":"EntryName","value":"Cadherin 24"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.60:FF:000014","properties":[{"key":"EntryName","value":"Cadherin 8"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.60","properties":[{"key":"EntryName","value":"Cadherins"},{"key":"MatchStatus","value":"5"}]},{"database":"Gene3D","id":"4.10.900.10","properties":[{"key":"EntryName","value":"TCF3-CBD (Catenin binding domain)"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR039808","properties":[{"key":"EntryName","value":"Cadherin"}]},{"database":"InterPro","id":"IPR002126","properties":[{"key":"EntryName","value":"Cadherin-like_dom"}]},{"database":"InterPro","id":"IPR015919","properties":[{"key":"EntryName","value":"Cadherin-like_sf"}]},{"database":"InterPro","id":"IPR020894","properties":[{"key":"EntryName","value":"Cadherin_CS"}]},{"database":"InterPro","id":"IPR000233","properties":[{"key":"EntryName","value":"Cadherin_Y-type_LIR"}]},{"database":"InterPro","id":"IPR027397","properties":[{"key":"EntryName","value":"Catenin-bd_sf"}]},{"database":"PANTHER","id":"PTHR24027:SF85","properties":[{"key":"EntryName","value":"CADHERIN-11"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR24027","properties":[{"key":"EntryName","value":"CADHERIN-23"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01049","properties":[{"key":"EntryName","value":"CADH_Y-type_LIR"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00028","properties":[{"key":"EntryName","value":"Cadherin"},{"key":"MatchStatus","value":"4"}]},{"database":"PRINTS","id":"PR00205","properties":[{"key":"EntryName","value":"CADHERIN"}]},{"database":"SMART","id":"SM00112","properties":[{"key":"EntryName","value":"CA"},{"key":"MatchStatus","value":"5"}]},{"database":"SUPFAM","id":"SSF49313","properties":[{"key":"EntryName","value":"Cadherin-like"},{"key":"MatchStatus","value":"5"}]},{"database":"PROSITE","id":"PS00232","properties":[{"key":"EntryName","value":"CADHERIN_1"},{"key":"MatchStatus","value":"3"}]},{"database":"PROSITE","id":"PS50268","properties":[{"key":"EntryName","value":"CADHERIN_2"},{"key":"MatchStatus","value":"5"}]}],"sequence":{"value":"MKENYCLQAALVCLGMLCHSHAFAPERRGHLRPSFHGHHEKGKEGQVLQRSKRGWVWNQFFVIEEYTGPDPVLVGRLHSDIDSGDGNIKYILSGEGAGTIFVIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTNRPLEPPSEFIVKVQDINDNPPEFLHETYHANVPERSNVGTSVIQVTASDADDPTYGNSAKLVYSILEGQPYFSVEAQTGIIRTALPNMDREAKEEYHVVIQAKDMGGHMGGLSGTTKVTITLTDVNDNPPKFPQSVYQMSVSEAAVPGEEVGRVKAKDPDIGENGLVTYNIVDGDGMESFEITTDYETQEGVIKLKKPVDFETKRAYSLKVEAANVHIDPKFISNGPFKDTVTVKISVEDADEPPMFLAPSYIHEVQENAAAGTVVGRVHAKDPDAANSPIRYSIDRHTDLDRFFTINPEDGFIKTTKPLDREETAWLNITVFAAEIHNRHQEAKVPVAIRVLDVNDNAPKFAAPYEGFICESDQTKPLSNQPIVTISADDKDDTANGPRFIFSLPPEIIHNPNFTVRDNRDNTAGVYARRGGFSRQKQDLYLLPIVISDGGIPPMSSTNTLTIKVCGCDVNGALLSCNAEAYILNAGLSTGALIAILACIVILLVIVVLFVTLRRQKKEPLIVFEEEDVRENIITYDDEGGGEEDTEAFDIATLQNPDGINGFIPRKDIKPEYQYMPRPGLRPAPNSVDVDDFINTRIQEADNDPTAPPYDSIQIYGYEGRGSVAGSLSSLESATTDSDLDYDYLQNWGPRFKKLADLYGSKDTFDDDS","length":796,"molWeight":87965,"crc64":"E17090EC95C59936","md5":"69EA131A33366891C796C274559515CB"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":2,"TISSUE SPECIFICITY":1,"DOMAIN":1,"DISEASE":3},"countByFeatureType":{"Signal":1,"Propeptide":1,"Chain":1,"Topological domain":2,"Transmembrane":1,"Domain":5,"Modified residue":2,"Glycosylation":2,"Alternative sequence":2,"Natural variant":13,"Sequence conflict":3},"uniParcId":"UPI000013D7C5"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q96CZ9","uniProtkbId":"Q96CZ9_HUMAN","entryAudit":{"firstPublicDate":"2001-12-01","lastAnnotationUpdateDate":"2026-06-10","lastSequenceUpdateDate":"2001-12-01","entryVersion":151,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAH13609.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAH13609.1"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"EAW83002.1"}],"value":"Cadherin 11, type 2, OB-cadherin (Osteoblast)"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAH13609.1"}],"value":"CDH11"},"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"EAW83002.1"}],"value":"hCG_26636"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004357"}],"value":"Cadherins are calcium-dependent cell adhesion proteins"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003318"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003318"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":796,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5014312586"},{"type":"Transmembrane","location":{"start":{"value":619,"modifier":"EXACT"},"end":{"value":640,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":79,"modifier":"EXACT"},"end":{"value":159,"modifier":"EXACT"}},"description":"Cadherin","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50268"}]},{"type":"Domain","location":{"start":{"value":160,"modifier":"EXACT"},"end":{"value":268,"modifier":"EXACT"}},"description":"Cadherin","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50268"}]},{"type":"Domain","location":{"start":{"value":269,"modifier":"EXACT"},"end":{"value":383,"modifier":"EXACT"}},"description":"Cadherin","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50268"}]},{"type":"Domain","location":{"start":{"value":384,"modifier":"EXACT"},"end":{"value":488,"modifier":"EXACT"}},"description":"Cadherin","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50268"}]},{"type":"Domain","location":{"start":{"value":488,"modifier":"EXACT"},"end":{"value":609,"modifier":"EXACT"}},"description":"Cadherin","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50268"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022837"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00043"}],"id":"KW-0106","category":"Ligand","name":"Calcium"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022889"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003318"}],"id":"KW-0130","category":"Biological process","name":"Cell adhesion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022685"}],"id":"KW-0165","category":"PTM","name":"Cleavage on pair of basic residues"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003318"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"11181995","citationType":"journal article","authors":["Venter J.C.","Adams M.D.","Myers E.W.","Li P.W.","Mural R.J.","Sutton G.G.","Smith H.O.","Yandell M.","Evans C.A.","Holt R.A.","Gocayne J.D.","Amanatides P.","Ballew R.M.","Huson D.H.","Wortman J.R.","Zhang Q.","Kodira C.D.","Zheng X.H.","Chen L.","Skupski M.","Subramanian G.","Thomas P.D.","Zhang J.","Gabor Miklos G.L.","Nelson C.","Broder S.","Clark A.G.","Nadeau J.","McKusick V.A.","Zinder N.","Levine A.J.","Roberts R.J.","Simon M.","Slayman C.","Hunkapiller M.","Bolanos R.","Delcher A.","Dew I.","Fasulo D.","Flanigan M.","Florea L.","Halpern A.","Hannenhalli S.","Kravitz S.","Levy S.","Mobarry C.","Reinert K.","Remington K.","Abu-Threideh J.","Beasley E.","Biddick K.","Bonazzi V.","Brandon R.","Cargill M.","Chandramouliswaran I.","Charlab R.","Chaturvedi K.","Deng Z.","Di Francesco V.","Dunn P.","Eilbeck K.","Evangelista C.","Gabrielian A.E.","Gan W.","Ge W.","Gong F.","Gu Z.","Guan P.","Heiman T.J.","Higgins M.E.","Ji R.R.","Ke Z.","Ketchum K.A.","Lai Z.","Lei Y.","Li Z.","Li J.","Liang Y.","Lin X.","Lu F.","Merkulov G.V.","Milshina N.","Moore H.M.","Naik A.K.","Narayan V.A.","Neelam B.","Nusskern D.","Rusch D.B.","Salzberg S.","Shao W.","Shue B.","Sun J.","Wang Z.","Wang A.","Wang X.","Wang J.","Wei M.","Wides R.","Xiao C.","Yan C.","Yao A.","Ye J.","Zhan M.","Zhang W.","Zhang H.","Zhao Q.","Zheng L.","Zhong F.","Zhong W.","Zhu S.","Zhao S.","Gilbert D.","Baumhueter S.","Spier G.","Carter C.","Cravchik A.","Woodage T.","Ali F.","An H.","Awe A.","Baldwin D.","Baden H.","Barnstead M.","Barrow I.","Beeson K.","Busam D.","Carver A.","Center A.","Cheng M.L.","Curry L.","Danaher S.","Davenport L.","Desilets R.","Dietz S.","Dodson K.","Doup L.","Ferriera S.","Garg N.","Gluecksmann A.","Hart B.","Haynes J.","Haynes C.","Heiner C.","Hladun S.","Hostin D.","Houck J.","Howland T.","Ibegwam C.","Johnson J.","Kalush F.","Kline L.","Koduru S.","Love A.","Mann F.","May D.","McCawley S.","McIntosh T.","McMullen I.","Moy M.","Moy L.","Murphy B.","Nelson K.","Pfannkoch C.","Pratts E.","Puri V.","Qureshi H.","Reardon M.","Rodriguez R.","Rogers Y.H.","Romblad D.","Ruhfel B.","Scott R.","Sitter C.","Smallwood M.","Stewart E.","Strong R.","Suh E.","Thomas R.","Tint N.N.","Tse S.","Vech C.","Wang G.","Wetter J.","Williams S.","Williams M.","Windsor S.","Winn-Deen E.","Wolfe K.","Zaveri J.","Zaveri K.","Abril J.F.","Guigo R.","Campbell M.J.","Sjolander K.V.","Karlak B.","Kejariwal A.","Mi H.","Lazareva B.","Hatton T.","Narechania A.","Diemer K.","Muruganujan A.","Guo N.","Sato S.","Bafna V.","Istrail S.","Lippert R.","Schwartz R.","Walenz B.","Yooseph S.","Allen D.","Basu A.","Baxendale J.","Blick L.","Caminha M.","Carnes-Stine J.","Caulk P.","Chiang Y.H.","Coyne M.","Dahlke C.","Mays A.","Dombroski M.","Donnelly M.","Ely D.","Esparham S.","Fosler C.","Gire H.","Glanowski S.","Glasser K.","Glodek A.","Gorokhov M.","Graham K.","Gropman B.","Harris M.","Heil J.","Henderson S.","Hoover J.","Jennings D.","Jordan C.","Jordan J.","Kasha J.","Kagan L.","Kraft C.","Levitsky A.","Lewis M.","Liu X.","Lopez J.","Ma D.","Majoros W.","McDaniel J.","Murphy S.","Newman M.","Nguyen T.","Nguyen N.","Nodell M.","Pan S.","Peck J.","Peterson M.","Rowe W.","Sanders R.","Scott J.","Simpson M.","Smith T.","Sprague A.","Stockwell T.","Turner R.","Venter E.","Wang M.","Wen M.","Wu D.","Wu M.","Xia A.","Zandieh A.","Zhu X."],"citationCrossReferences":[{"database":"PubMed","id":"11181995"},{"database":"DOI","id":"10.1126/science.1058040"}],"title":"The sequence of the human genome.","publicationDate":"2001","journal":"Science","firstPage":"1304","lastPage":"1351","volume":"291"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"EAW83002.1"}]},{"referenceNumber":2,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"authors":["Gerhard D.S.","Wagner L.","Feingold E.A.","Shenmen C.M.","Grouse L.H.","Schuler G.","Klein S.L.","Old S.","Rasooly R.","Good P.","Guyer M.","Peck A.M.","Derge J.G.","Lipman D.","Collins F.S.","Jang W.","Sherry S.","Feolo M.","Misquitta L.","Lee E.","Rotmistrovsky K.","Greenhut S.F.","Schaefer C.F.","Buetow K.","Bonner T.I.","Haussler D.","Kent J.","Kiekhaus M.","Furey T.","Brent M.","Prange C.","Schreiber K.","Shapiro N.","Bhat N.K.","Hopkins R.F.","Hsie F.","Driscoll T.","Soares M.B.","Casavant T.L.","Scheetz T.E.","Brown-stein M.J.","Usdin T.B.","Toshiyuki S.","Carninci P.","Piao Y.","Dudekula D.B.","Ko M.S.","Kawakami K.","Suzuki Y.","Sugano S.","Gruber C.E.","Smith M.R.","Simmons B.","Moore T.","Waterman R.","Johnson S.L.","Ruan Y.","Wei C.L.","Mathavan S.","Gunaratne P.H.","Wu J.","Garcia A.M.","Hulyk S.W.","Fuh E.","Yuan Y.","Sneed A.","Kowis C.","Hodgson A.","Muzny D.M.","McPherson J.","Gibbs R.A.","Fahey J.","Helton E.","Ketteman M.","Madan A.","Rodrigues S.","Sanchez A.","Whiting M.","Madari A.","Young A.C.","Wetherby K.D.","Granite S.J.","Kwong P.N.","Brinkley C.P.","Pearson R.L.","Bouffard G.G.","Blakesly R.W.","Green E.D.","Dickson M.C.","Rodriguez A.C.","Grimwood J.","Schmutz J.","Myers R.M.","Butterfield Y.S.","Griffith M.","Griffith O.L.","Krzywinski M.I.","Liao N.","Morin R.","Morrin R.","Palmquist D.","Petrescu A.S.","Skalska U.","Smailus D.E.","Stott J.M.","Schnerch A.","Schein J.E.","Jones S.J.","Holt R.A.","Baross A.","Marra M.A.","Clifton S.","Makowski K.A.","Bosak S.","Malek J."],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAH13609.1"}],"value":"Brain","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAH13609.1"}]},{"referenceNumber":3,"citation":{"id":"CI-56FT96O07V0QG","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"JUL-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"EAW83002.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"BC013609","properties":[{"key":"ProteinId","value":"AAH13609.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"CH471092","properties":[{"key":"ProteinId","value":"EAW83002.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"Q96CZ9","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q96CZ9","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q96CZ9","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"8188793at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"CDH11","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005509","properties":[{"key":"GoTerm","value":"F:calcium ion binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0007156","properties":[{"key":"GoTerm","value":"P:homophilic cell-cell adhesion"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd11304","properties":[{"key":"EntryName","value":"Cadherin_repeat"},{"key":"MatchStatus","value":"4"}]},{"database":"FunFam","id":"4.10.900.10:FF:000001","properties":[{"key":"EntryName","value":"Cadherin 2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.60:FF:000008","properties":[{"key":"EntryName","value":"Cadherin 24"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.60:FF:000009","properties":[{"key":"EntryName","value":"Cadherin 24"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.60:FF:000017","properties":[{"key":"EntryName","value":"Cadherin 24"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.60:FF:000014","properties":[{"key":"EntryName","value":"Cadherin 8"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.60:FF:000373","properties":[{"key":"EntryName","value":"Ventral neural cadherin"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.60","properties":[{"key":"EntryName","value":"Cadherins"},{"key":"MatchStatus","value":"5"}]},{"database":"Gene3D","id":"4.10.900.10","properties":[{"key":"EntryName","value":"TCF3-CBD (Catenin binding domain)"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR039808","properties":[{"key":"EntryName","value":"Cadherin"}]},{"database":"InterPro","id":"IPR002126","properties":[{"key":"EntryName","value":"Cadherin-like_dom"}]},{"database":"InterPro","id":"IPR015919","properties":[{"key":"EntryName","value":"Cadherin-like_sf"}]},{"database":"InterPro","id":"IPR020894","properties":[{"key":"EntryName","value":"Cadherin_CS"}]},{"database":"InterPro","id":"IPR000233","properties":[{"key":"EntryName","value":"Cadherin_Y-type_LIR"}]},{"database":"InterPro","id":"IPR027397","properties":[{"key":"EntryName","value":"Catenin-bd_sf"}]},{"database":"PANTHER","id":"PTHR24027:SF85","properties":[{"key":"EntryName","value":"CADHERIN-11"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR24027","properties":[{"key":"EntryName","value":"CADHERIN-23"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01049","properties":[{"key":"EntryName","value":"CADH_Y-type_LIR"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00028","properties":[{"key":"EntryName","value":"Cadherin"},{"key":"MatchStatus","value":"4"}]},{"database":"PRINTS","id":"PR00205","properties":[{"key":"EntryName","value":"CADHERIN"}]},{"database":"SMART","id":"SM00112","properties":[{"key":"EntryName","value":"CA"},{"key":"MatchStatus","value":"5"}]},{"database":"SUPFAM","id":"SSF49313","properties":[{"key":"EntryName","value":"Cadherin-like"},{"key":"MatchStatus","value":"5"}]},{"database":"PROSITE","id":"PS00232","properties":[{"key":"EntryName","value":"CADHERIN_1"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS50268","properties":[{"key":"EntryName","value":"CADHERIN_2"},{"key":"MatchStatus","value":"5"}]}],"sequence":{"value":"MKENYCLQAALVCLGMLCHSHAFAPERRGHLRPSFHGHHEKGKEGQVLQRSKRGWVWNQFFVIEEYTGPDPVLVGRLHSDIDSGDGNIKYILSGEGAGTIFVIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTNRPLEPPSEFIVKVQDINDNPPEFLHETYHANVPERSNVGTSVIQVTASDADDPTYGNSAKLVYSILEGQPYFSVEAQTGIIRTALPNMDREAKEEYHVVIQAKDMGGHMGGLSGTTKVMITLTDVNDNPPKFPQSVYQMSVSEAAVPGEEVGRVKAKDPDIGENGLVTYNIVDGDGMESFEITTDYETQEGVIKLKKPVDFETKRAYSLKVEAANVHIDPKFISNGPFKDTVTVKIAVEDADEPPMFLAPSYIHEVQENAAAGTVVGRVHAKDPDAANSPIRYSIDRHTDLDRFFTINPEDGFIKTTKPLDREETAWLNITVFAAEIHNRHQEAKVPVAIRVLDVNDNAPKFAAPYEGFICESDQTKPLSNQPIVTISADDKDDTANGPRFIFSLPPEIIHNPNFTVRDNRDNTAGVYARRGGFSRQKQDLYLLPIVISDGGIPPMSSTNTLTIKVCGCDVNGALLSCNAEAYILNAGLSTGALIAILACIVILLVIVVLFVTLRRQKKEPLIVFEEEDVRENIITYDDEGGGEEDTEAFDIATLQNPDGINGFIPRKDIKPEYQYMPRPGLRPAPNSVDVDDFINTRIQEADNDPTAPPYDSIQIYGYEGRGSVAGSLSSLESATTDSDLDYDYLQNWGPRFKKLADLYGSKDTFDDDS","length":796,"molWeight":87979,"crc64":"8497F9B834F7547C","md5":"0AB399572EB009AA144CEDD048FE8560"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Transmembrane":1,"Domain":5},"uniParcId":"UPI000006DDBE"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"H3BP26","uniProtkbId":"H3BP26_HUMAN","entryAudit":{"firstPublicDate":"2012-04-18","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2016-10-05","entryVersion":75,"sequenceVersion":8},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000455120.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000455120.1"}],"value":"Cadherin 11"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000455120.1"}],"value":"CDH11"}}],"features":[{"type":"Region","location":{"start":{"value":29,"modifier":"EXACT"},"end":{"value":53,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":29,"modifier":"EXACT"},"end":{"value":40,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":53,"modifier":"EXACT"},"end":{"value":53,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000455120.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"H3BP26"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000455120.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000455120.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15616553","citationType":"journal article","authors":["Martin J.","Han C.","Gordon L.A.","Terry A.","Prabhakar S.","She X.","Xie G.","Hellsten U.","Chan Y.M.","Altherr M.","Couronne O.","Aerts A.","Bajorek E.","Black S.","Blumer H.","Branscomb E.","Brown N.C.","Bruno W.J.","Buckingham J.M.","Callen D.F.","Campbell C.S.","Campbell M.L.","Campbell E.W.","Caoile C.","Challacombe J.F.","Chasteen L.A.","Chertkov O.","Chi H.C.","Christensen M.","Clark L.M.","Cohn J.D.","Denys M.","Detter J.C.","Dickson M.","Dimitrijevic-Bussod M.","Escobar J.","Fawcett J.J.","Flowers D.","Fotopulos D.","Glavina T.","Gomez M.","Gonzales E.","Goodstein D.","Goodwin L.A.","Grady D.L.","Grigoriev I.","Groza M.","Hammon N.","Hawkins T.","Haydu L.","Hildebrand C.E.","Huang W.","Israni S.","Jett J.","Jewett P.B.","Kadner K.","Kimball H.","Kobayashi A.","Krawczyk M.C.","Leyba T.","Longmire J.L.","Lopez F.","Lou Y.","Lowry S.","Ludeman T.","Manohar C.F.","Mark G.A.","McMurray K.L.","Meincke L.J.","Morgan J.","Moyzis R.K.","Mundt M.O.","Munk A.C.","Nandkeshwar R.D.","Pitluck S.","Pollard M.","Predki P.","Parson-Quintana B.","Ramirez L.","Rash S.","Retterer J.","Ricke D.O.","Robinson D.L.","Rodriguez A.","Salamov A.","Saunders E.H.","Scott D.","Shough T.","Stallings R.L.","Stalvey M.","Sutherland R.D.","Tapia R.","Tesmer J.G.","Thayer N.","Thompson L.S.","Tice H.","Torney D.C.","Tran-Gyamfi M.","Tsai M.","Ulanovsky L.E.","Ustaszewska A.","Vo N.","White P.S.","Williams A.L.","Wills P.L.","Wu J.R.","Wu K.","Yang J.","Dejong P.","Bruce D.","Doggett N.A.","Deaven L.","Schmutz J.","Grimwood J.","Richardson P.","Rokhsar D.S.","Eichler E.E.","Gilna P.","Lucas S.M.","Myers R.M.","Rubin E.M.","Pennacchio L.A."],"citationCrossReferences":[{"database":"PubMed","id":"15616553"},{"database":"DOI","id":"10.1038/nature03187"}],"title":"The sequence and analysis of duplication-rich human chromosome 16.","publicationDate":"2004","journal":"Nature","firstPage":"988","lastPage":"994","volume":"432"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000455120.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000455120.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC010533","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC137643","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"H3BP26","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"H3BP26","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"4584","properties":[{"key":"antibodies","value":"857 antibodies from 40 providers"}]},{"database":"Ensembl","id":"ENST00000562712.5","properties":[{"key":"ProteinId","value":"ENSP00000455120.1"},{"key":"GeneId","value":"ENSG00000140937.15"}]},{"database":"UCSC","id":"uc059vgq.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:1750","properties":[{"key":"GeneName","value":"CDH11"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000140937","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000153691","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"ERYFVIN","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"8188793at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"CDH11","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 16"}]},{"database":"Bgee","id":"ENSG00000140937","properties":[{"key":"ExpressionPatterns","value":"Expressed in periodontal ligament and 195 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"H3BP26","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]}],"sequence":{"value":"MKENYCLQAALVCLGMLCHSHAFAPERRGHLRPSFHGHHEKGKEGQVLQRSKR","length":53,"molWeight":6081,"crc64":"16160345631F3FA7","md5":"A256F1614F772A9EF91BA182DCB2B2AB"},"extraAttributes":{"countByFeatureType":{"Region":1,"Compositional bias":1,"Non-terminal residue":1},"uniParcId":"UPI0003F47B84"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"H3BSM4","uniProtkbId":"H3BSM4_HUMAN","entryAudit":{"firstPublicDate":"2012-04-18","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2012-04-18","entryVersion":66,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000456772.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000456772.1"}],"value":"Cadherin 11"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000456772.1"}],"value":"CDH11"}}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":65,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5003580673"},{"type":"Non-terminal residue","location":{"start":{"value":65,"modifier":"EXACT"},"end":{"value":65,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000456772.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"H3BSM4"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000456772.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000456772.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15616553","citationType":"journal article","authors":["Martin J.","Han C.","Gordon L.A.","Terry A.","Prabhakar S.","She X.","Xie G.","Hellsten U.","Chan Y.M.","Altherr M.","Couronne O.","Aerts A.","Bajorek E.","Black S.","Blumer H.","Branscomb E.","Brown N.C.","Bruno W.J.","Buckingham J.M.","Callen D.F.","Campbell C.S.","Campbell M.L.","Campbell E.W.","Caoile C.","Challacombe J.F.","Chasteen L.A.","Chertkov O.","Chi H.C.","Christensen M.","Clark L.M.","Cohn J.D.","Denys M.","Detter J.C.","Dickson M.","Dimitrijevic-Bussod M.","Escobar J.","Fawcett J.J.","Flowers D.","Fotopulos D.","Glavina T.","Gomez M.","Gonzales E.","Goodstein D.","Goodwin L.A.","Grady D.L.","Grigoriev I.","Groza M.","Hammon N.","Hawkins T.","Haydu L.","Hildebrand C.E.","Huang W.","Israni S.","Jett J.","Jewett P.B.","Kadner K.","Kimball H.","Kobayashi A.","Krawczyk M.C.","Leyba T.","Longmire J.L.","Lopez F.","Lou Y.","Lowry S.","Ludeman T.","Manohar C.F.","Mark G.A.","McMurray K.L.","Meincke L.J.","Morgan J.","Moyzis R.K.","Mundt M.O.","Munk A.C.","Nandkeshwar R.D.","Pitluck S.","Pollard M.","Predki P.","Parson-Quintana B.","Ramirez L.","Rash S.","Retterer J.","Ricke D.O.","Robinson D.L.","Rodriguez A.","Salamov A.","Saunders E.H.","Scott D.","Shough T.","Stallings R.L.","Stalvey M.","Sutherland R.D.","Tapia R.","Tesmer J.G.","Thayer N.","Thompson L.S.","Tice H.","Torney D.C.","Tran-Gyamfi M.","Tsai M.","Ulanovsky L.E.","Ustaszewska A.","Vo N.","White P.S.","Williams A.L.","Wills P.L.","Wu J.R.","Wu K.","Yang J.","Dejong P.","Bruce D.","Doggett N.A.","Deaven L.","Schmutz J.","Grimwood J.","Richardson P.","Rokhsar D.S.","Eichler E.E.","Gilna P.","Lucas S.M.","Myers R.M.","Rubin E.M.","Pennacchio L.A."],"citationCrossReferences":[{"database":"PubMed","id":"15616553"},{"database":"DOI","id":"10.1038/nature03187"}],"title":"The sequence and analysis of duplication-rich human chromosome 16.","publicationDate":"2004","journal":"Nature","firstPage":"988","lastPage":"994","volume":"432"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000456772.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000456772.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC010533","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC137643","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"H3BSM4","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"H3BSM4","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"4584","properties":[{"key":"antibodies","value":"857 antibodies from 40 providers"}]},{"database":"Ensembl","id":"ENST00000564317.5","properties":[{"key":"ProteinId","value":"ENSP00000456772.1"},{"key":"GeneId","value":"ENSG00000140937.15"}]},{"database":"UCSC","id":"uc059vgp.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:1750","properties":[{"key":"GeneName","value":"CDH11"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000140937","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000153691","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_2855520_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"ERYFVIN","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"8188793at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"CDH11","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 16"}]},{"database":"Bgee","id":"ENSG00000140937","properties":[{"key":"ExpressionPatterns","value":"Expressed in periodontal ligament and 195 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"H3BSM4","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]}],"sequence":{"value":"MKENYCLQAALVCLGMLCHSHAFAPERRGHLRPSFHGHHEKGKEGQVLQRSKRGWVWNQFFVIEE","length":65,"molWeight":7617,"crc64":"25A54E51B777746F","md5":"9DE26EAED34C9238A11F53E7971B9575"},"extraAttributes":{"countByFeatureType":{"Signal":1,"Chain":1,"Non-terminal residue":1},"uniParcId":"UPI0002466E96"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"H3BR78","uniProtkbId":"H3BR78_HUMAN","entryAudit":{"firstPublicDate":"2012-04-18","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2012-04-18","entryVersion":60,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000456110.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000456110.1"}],"value":"Cadherin 11"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000456110.1"}],"value":"CDH11"}}],"features":[{"type":"Non-terminal residue","location":{"start":{"value":22,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000456110.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000456110.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000456110.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15616553","citationType":"journal article","authors":["Martin J.","Han C.","Gordon L.A.","Terry A.","Prabhakar S.","She X.","Xie G.","Hellsten U.","Chan Y.M.","Altherr M.","Couronne O.","Aerts A.","Bajorek E.","Black S.","Blumer H.","Branscomb E.","Brown N.C.","Bruno W.J.","Buckingham J.M.","Callen D.F.","Campbell C.S.","Campbell M.L.","Campbell E.W.","Caoile C.","Challacombe J.F.","Chasteen L.A.","Chertkov O.","Chi H.C.","Christensen M.","Clark L.M.","Cohn J.D.","Denys M.","Detter J.C.","Dickson M.","Dimitrijevic-Bussod M.","Escobar J.","Fawcett J.J.","Flowers D.","Fotopulos D.","Glavina T.","Gomez M.","Gonzales E.","Goodstein D.","Goodwin L.A.","Grady D.L.","Grigoriev I.","Groza M.","Hammon N.","Hawkins T.","Haydu L.","Hildebrand C.E.","Huang W.","Israni S.","Jett J.","Jewett P.B.","Kadner K.","Kimball H.","Kobayashi A.","Krawczyk M.C.","Leyba T.","Longmire J.L.","Lopez F.","Lou Y.","Lowry S.","Ludeman T.","Manohar C.F.","Mark G.A.","McMurray K.L.","Meincke L.J.","Morgan J.","Moyzis R.K.","Mundt M.O.","Munk A.C.","Nandkeshwar R.D.","Pitluck S.","Pollard M.","Predki P.","Parson-Quintana B.","Ramirez L.","Rash S.","Retterer J.","Ricke D.O.","Robinson D.L.","Rodriguez A.","Salamov A.","Saunders E.H.","Scott D.","Shough T.","Stallings R.L.","Stalvey M.","Sutherland R.D.","Tapia R.","Tesmer J.G.","Thayer N.","Thompson L.S.","Tice H.","Torney D.C.","Tran-Gyamfi M.","Tsai M.","Ulanovsky L.E.","Ustaszewska A.","Vo N.","White P.S.","Williams A.L.","Wills P.L.","Wu J.R.","Wu K.","Yang J.","Dejong P.","Bruce D.","Doggett N.A.","Deaven L.","Schmutz J.","Grimwood J.","Richardson P.","Rokhsar D.S.","Eichler E.E.","Gilna P.","Lucas S.M.","Myers R.M.","Rubin E.M.","Pennacchio L.A."],"citationCrossReferences":[{"database":"PubMed","id":"15616553"},{"database":"DOI","id":"10.1038/nature03187"}],"title":"The sequence and analysis of duplication-rich human chromosome 16.","publicationDate":"2004","journal":"Nature","firstPage":"988","lastPage":"994","volume":"432"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000456110.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000456110.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC010533","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC137643","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"H3BR78","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"4584","properties":[{"key":"antibodies","value":"857 antibodies from 40 providers"}]},{"database":"Ensembl","id":"ENST00000562325.5","properties":[{"key":"ProteinId","value":"ENSP00000456110.1"},{"key":"GeneId","value":"ENSG00000140937.15"}]},{"database":"UCSC","id":"uc059vgs.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:1750","properties":[{"key":"GeneName","value":"CDH11"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000140937","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000153691","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_3426167_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"ERYFVIN","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"8188793at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"CDH11","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 16"}]},{"database":"Bgee","id":"ENSG00000140937","properties":[{"key":"ExpressionPatterns","value":"Expressed in periodontal ligament and 195 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"H3BR78","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]}],"sequence":{"value":"MKENYCLQAALVCLGMLCHSHA","length":22,"molWeight":2436,"crc64":"166ABF3D7246C6A3","md5":"A76B61E32AE7FFC657841BD3C3645A47"},"extraAttributes":{"countByFeatureType":{"Non-terminal residue":1},"uniParcId":"UPI0002466E99"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"H3BUU9","uniProtkbId":"H3BUU9_HUMAN","entryAudit":{"firstPublicDate":"2012-04-18","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2012-04-18","entryVersion":94,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000457812.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000457812.1"}],"value":"Cadherin 11"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000457812.1"}],"value":"CDH11"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004357"}],"value":"Cadherins are calcium-dependent cell adhesion proteins"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003318"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003318"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]}],"features":[{"type":"Transmembrane","location":{"start":{"value":493,"modifier":"EXACT"},"end":{"value":514,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":4,"modifier":"EXACT"},"end":{"value":33,"modifier":"EXACT"}},"description":"Cadherin","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50268"}]},{"type":"Domain","location":{"start":{"value":34,"modifier":"EXACT"},"end":{"value":142,"modifier":"EXACT"}},"description":"Cadherin","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50268"}]},{"type":"Domain","location":{"start":{"value":143,"modifier":"EXACT"},"end":{"value":257,"modifier":"EXACT"}},"description":"Cadherin","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50268"}]},{"type":"Domain","location":{"start":{"value":258,"modifier":"EXACT"},"end":{"value":362,"modifier":"EXACT"}},"description":"Cadherin","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50268"}]},{"type":"Domain","location":{"start":{"value":362,"modifier":"EXACT"},"end":{"value":483,"modifier":"EXACT"}},"description":"Cadherin","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50268"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022837"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00043"}],"id":"KW-0106","category":"Ligand","name":"Calcium"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022889"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003318"}],"id":"KW-0130","category":"Biological process","name":"Cell adhesion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022685"}],"id":"KW-0165","category":"PTM","name":"Cleavage on pair of basic residues"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"H3BUU9"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"H3BUU9"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003318"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000457812.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000457812.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15616553","citationType":"journal article","authors":["Martin J.","Han C.","Gordon L.A.","Terry A.","Prabhakar S.","She X.","Xie G.","Hellsten U.","Chan Y.M.","Altherr M.","Couronne O.","Aerts A.","Bajorek E.","Black S.","Blumer H.","Branscomb E.","Brown N.C.","Bruno W.J.","Buckingham J.M.","Callen D.F.","Campbell C.S.","Campbell M.L.","Campbell E.W.","Caoile C.","Challacombe J.F.","Chasteen L.A.","Chertkov O.","Chi H.C.","Christensen M.","Clark L.M.","Cohn J.D.","Denys M.","Detter J.C.","Dickson M.","Dimitrijevic-Bussod M.","Escobar J.","Fawcett J.J.","Flowers D.","Fotopulos D.","Glavina T.","Gomez M.","Gonzales E.","Goodstein D.","Goodwin L.A.","Grady D.L.","Grigoriev I.","Groza M.","Hammon N.","Hawkins T.","Haydu L.","Hildebrand C.E.","Huang W.","Israni S.","Jett J.","Jewett P.B.","Kadner K.","Kimball H.","Kobayashi A.","Krawczyk M.C.","Leyba T.","Longmire J.L.","Lopez F.","Lou Y.","Lowry S.","Ludeman T.","Manohar C.F.","Mark G.A.","McMurray K.L.","Meincke L.J.","Morgan J.","Moyzis R.K.","Mundt M.O.","Munk A.C.","Nandkeshwar R.D.","Pitluck S.","Pollard M.","Predki P.","Parson-Quintana B.","Ramirez L.","Rash S.","Retterer J.","Ricke D.O.","Robinson D.L.","Rodriguez A.","Salamov A.","Saunders E.H.","Scott D.","Shough T.","Stallings R.L.","Stalvey M.","Sutherland R.D.","Tapia R.","Tesmer J.G.","Thayer N.","Thompson L.S.","Tice H.","Torney D.C.","Tran-Gyamfi M.","Tsai M.","Ulanovsky L.E.","Ustaszewska A.","Vo N.","White P.S.","Williams A.L.","Wills P.L.","Wu J.R.","Wu K.","Yang J.","Dejong P.","Bruce D.","Doggett N.A.","Deaven L.","Schmutz J.","Grimwood J.","Richardson P.","Rokhsar D.S.","Eichler E.E.","Gilna P.","Lucas S.M.","Myers R.M.","Rubin E.M.","Pennacchio L.A."],"citationCrossReferences":[{"database":"PubMed","id":"15616553"},{"database":"DOI","id":"10.1038/nature03187"}],"title":"The sequence and analysis of duplication-rich human chromosome 16.","publicationDate":"2004","journal":"Nature","firstPage":"988","lastPage":"994","volume":"432"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000457812.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000457812.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC010533","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC137643","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"NP_001317505.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001330576.2"}]},{"database":"RefSeq","id":"XP_047289442.1","properties":[{"key":"NucleotideSequenceId","value":"XM_047433486.1"}]},{"database":"RefSeq","id":"XP_054235327.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054379352.1"}]},{"database":"AlphaFoldDB","id":"H3BUU9","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"H3BUU9","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"H3BUU9","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"43032","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"4584","properties":[{"key":"antibodies","value":"857 antibodies from 40 providers"}]},{"database":"DNASU","id":"1009","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000566827.5","properties":[{"key":"ProteinId","value":"ENSP00000457812.1"},{"key":"GeneId","value":"ENSG00000140937.15"}]},{"database":"GeneID","id":"1009","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc010vin.3","properties":[{"key":"OrganismName","value":"human"}]},{"database":"CTD","id":"1009","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"1009","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:1750","properties":[{"key":"GeneName","value":"CDH11"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000140937","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000153691","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_005284_3_1_1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"8188793at2759","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"1009","properties":[{"key":"hits","value":"16 hits in 1149 CRISPR screens"}]},{"database":"ChiTaRS","id":"CDH11","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 16"}]},{"database":"Bgee","id":"ENSG00000140937","properties":[{"key":"ExpressionPatterns","value":"Expressed in periodontal ligament and 195 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"H3BUU9","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005509","properties":[{"key":"GoTerm","value":"F:calcium ion binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0007156","properties":[{"key":"GoTerm","value":"P:homophilic cell-cell adhesion"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd11304","properties":[{"key":"EntryName","value":"Cadherin_repeat"},{"key":"MatchStatus","value":"3"}]},{"database":"FunFam","id":"4.10.900.10:FF:000001","properties":[{"key":"EntryName","value":"Cadherin 2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.60:FF:000008","properties":[{"key":"EntryName","value":"Cadherin 24"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.60:FF:000012","properties":[{"key":"EntryName","value":"Cadherin 24"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.60:FF:000017","properties":[{"key":"EntryName","value":"Cadherin 24"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.60:FF:000014","properties":[{"key":"EntryName","value":"Cadherin 8"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.60","properties":[{"key":"EntryName","value":"Cadherins"},{"key":"MatchStatus","value":"4"}]},{"database":"Gene3D","id":"4.10.900.10","properties":[{"key":"EntryName","value":"TCF3-CBD (Catenin binding domain)"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR039808","properties":[{"key":"EntryName","value":"Cadherin"}]},{"database":"InterPro","id":"IPR002126","properties":[{"key":"EntryName","value":"Cadherin-like_dom"}]},{"database":"InterPro","id":"IPR015919","properties":[{"key":"EntryName","value":"Cadherin-like_sf"}]},{"database":"InterPro","id":"IPR020894","properties":[{"key":"EntryName","value":"Cadherin_CS"}]},{"database":"InterPro","id":"IPR000233","properties":[{"key":"EntryName","value":"Cadherin_Y-type_LIR"}]},{"database":"InterPro","id":"IPR027397","properties":[{"key":"EntryName","value":"Catenin-bd_sf"}]},{"database":"PANTHER","id":"PTHR24027:SF85","properties":[{"key":"EntryName","value":"CADHERIN-11"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR24027","properties":[{"key":"EntryName","value":"CADHERIN-23"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01049","properties":[{"key":"EntryName","value":"CADH_Y-type_LIR"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00028","properties":[{"key":"EntryName","value":"Cadherin"},{"key":"MatchStatus","value":"3"}]},{"database":"PRINTS","id":"PR00205","properties":[{"key":"EntryName","value":"CADHERIN"}]},{"database":"SMART","id":"SM00112","properties":[{"key":"EntryName","value":"CA"},{"key":"MatchStatus","value":"4"}]},{"database":"SUPFAM","id":"SSF49313","properties":[{"key":"EntryName","value":"Cadherin-like"},{"key":"MatchStatus","value":"4"}]},{"database":"PROSITE","id":"PS00232","properties":[{"key":"EntryName","value":"CADHERIN_1"},{"key":"MatchStatus","value":"3"}]},{"database":"PROSITE","id":"PS50268","properties":[{"key":"EntryName","value":"CADHERIN_2"},{"key":"MatchStatus","value":"5"}]}],"sequence":{"value":"MAQAVDRDTNRPLEPPSEFIVKVQDINDNPPEFLHETYHANVPERSNVGTSVIQVTASDADDPTYGNSAKLVYSILEGQPYFSVEAQTGIIRTALPNMDREAKEEYHVVIQAKDMGGHMGGLSGTTKVTITLTDVNDNPPKFPQSVYQMSVSEAAVPGEEVGRVKAKDPDIGENGLVTYNIVDGDGMESFEITTDYETQEGVIKLKKPVDFETKRAYSLKVEAANVHIDPKFISNGPFKDTVTVKISVEDADEPPMFLAPSYIHEVQENAAAGTVVGRVHAKDPDAANSPIRYSIDRHTDLDRFFTINPEDGFIKTTKPLDREETAWLNITVFAAEIHNRHQEAKVPVAIRVLDVNDNAPKFAAPYEGFICESDQTKPLSNQPIVTISADDKDDTANGPRFIFSLPPEIIHNPNFTVRDNRDNTAGVYARRGGFSRQKQDLYLLPIVISDGGIPPMSSTNTLTIKVCGCDVNGALLSCNAEAYILNAGLSTGALIAILACIVILLVIVVLFVTLRRQKKEPLIVFEEEDVRENIITYDDEGGGEEDTEAFDIATLQNPDGINGFIPRKDIKPEYQYMPRPGLRPAPNSVDVDDFINTRIQEADNDPTAPPYDSIQIYGYEGRGSVAGSLSSLESATTDSDLDYDYLQNWGPRFKKLADLYGSKDTFDDDS","length":670,"molWeight":73793,"crc64":"F8CBF4E3BD77712D","md5":"02AAF51E867AE0EBABD858F61E0A57F2"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Transmembrane":1,"Domain":5},"uniParcId":"UPI0002466E93"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A087X227","uniProtkbId":"A0A087X227_HUMAN","entryAudit":{"firstPublicDate":"2014-10-29","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":61,"sequenceVersion":3},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000484650.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000484650.1"}],"value":"Cadherin 11"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000484650.1"}],"value":"CDH11"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004370"}],"value":"Membrane","id":"SL-0162"}}]}],"features":[{"type":"Domain","location":{"start":{"value":3,"modifier":"EXACT"},"end":{"value":60,"modifier":"EXACT"}},"description":"Cadherin","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50268"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":13,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000484650.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022837"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00043"}],"id":"KW-0106","category":"Ligand","name":"Calcium"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022889"}],"id":"KW-0130","category":"Biological process","name":"Cell adhesion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0A087X227"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000484650.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000484650.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15616553","citationType":"journal article","authors":["Martin J.","Han C.","Gordon L.A.","Terry A.","Prabhakar S.","She X.","Xie G.","Hellsten U.","Chan Y.M.","Altherr M.","Couronne O.","Aerts A.","Bajorek E.","Black S.","Blumer H.","Branscomb E.","Brown N.C.","Bruno W.J.","Buckingham J.M.","Callen D.F.","Campbell C.S.","Campbell M.L.","Campbell E.W.","Caoile C.","Challacombe J.F.","Chasteen L.A.","Chertkov O.","Chi H.C.","Christensen M.","Clark L.M.","Cohn J.D.","Denys M.","Detter J.C.","Dickson M.","Dimitrijevic-Bussod M.","Escobar J.","Fawcett J.J.","Flowers D.","Fotopulos D.","Glavina T.","Gomez M.","Gonzales E.","Goodstein D.","Goodwin L.A.","Grady D.L.","Grigoriev I.","Groza M.","Hammon N.","Hawkins T.","Haydu L.","Hildebrand C.E.","Huang W.","Israni S.","Jett J.","Jewett P.B.","Kadner K.","Kimball H.","Kobayashi A.","Krawczyk M.C.","Leyba T.","Longmire J.L.","Lopez F.","Lou Y.","Lowry S.","Ludeman T.","Manohar C.F.","Mark G.A.","McMurray K.L.","Meincke L.J.","Morgan J.","Moyzis R.K.","Mundt M.O.","Munk A.C.","Nandkeshwar R.D.","Pitluck S.","Pollard M.","Predki P.","Parson-Quintana B.","Ramirez L.","Rash S.","Retterer J.","Ricke D.O.","Robinson D.L.","Rodriguez A.","Salamov A.","Saunders E.H.","Scott D.","Shough T.","Stallings R.L.","Stalvey M.","Sutherland R.D.","Tapia R.","Tesmer J.G.","Thayer N.","Thompson L.S.","Tice H.","Torney D.C.","Tran-Gyamfi M.","Tsai M.","Ulanovsky L.E.","Ustaszewska A.","Vo N.","White P.S.","Williams A.L.","Wills P.L.","Wu J.R.","Wu K.","Yang J.","Dejong P.","Bruce D.","Doggett N.A.","Deaven L.","Schmutz J.","Grimwood J.","Richardson P.","Rokhsar D.S.","Eichler E.E.","Gilna P.","Lucas S.M.","Myers R.M.","Rubin E.M.","Pennacchio L.A."],"citationCrossReferences":[{"database":"PubMed","id":"15616553"},{"database":"DOI","id":"10.1038/nature03187"}],"title":"The sequence and analysis of duplication-rich human chromosome 16.","publicationDate":"2004","journal":"Nature","firstPage":"988","lastPage":"994","volume":"432"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000484650.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000484650.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC010533","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC137643","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"SMR","id":"A0A087X227","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"A0A087X227","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"A0A087X227","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"4584","properties":[{"key":"antibodies","value":"857 antibodies from 40 providers"}]},{"database":"Ensembl","id":"ENST00000619158.1","properties":[{"key":"ProteinId","value":"ENSP00000484650.1"},{"key":"GeneId","value":"ENSG00000140937.15"}]},{"database":"UCSC","id":"uc059vgl.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:1750","properties":[{"key":"GeneName","value":"CDH11"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000140937","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000153691","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_2928635_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"8188793at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"CDH11","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 16"}]},{"database":"Bgee","id":"ENSG00000140937","properties":[{"key":"ExpressionPatterns","value":"Expressed in periodontal ligament and 195 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"A0A087X227","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005509","properties":[{"key":"GoTerm","value":"F:calcium ion binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0007156","properties":[{"key":"GoTerm","value":"P:homophilic cell-cell adhesion"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd11304","properties":[{"key":"EntryName","value":"Cadherin_repeat"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.60","properties":[{"key":"EntryName","value":"Cadherins"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR039808","properties":[{"key":"EntryName","value":"Cadherin"}]},{"database":"InterPro","id":"IPR002126","properties":[{"key":"EntryName","value":"Cadherin-like_dom"}]},{"database":"InterPro","id":"IPR015919","properties":[{"key":"EntryName","value":"Cadherin-like_sf"}]},{"database":"PANTHER","id":"PTHR24027:SF85","properties":[{"key":"EntryName","value":"CADHERIN-11"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR24027","properties":[{"key":"EntryName","value":"CADHERIN-23"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00028","properties":[{"key":"EntryName","value":"Cadherin"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF49313","properties":[{"key":"EntryName","value":"Cadherin-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50268","properties":[{"key":"EntryName","value":"CADHERIN_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"XMSVSEAAVPGEEVGRVKAKDPDIGENGLVTYNIVDGDGMESFEITTDYETQEGVIKLKKVS","length":62,"molWeight":6659,"crc64":"07239105D0EA4345","md5":"F85F3FC1C3445BC835DC1EC71F102B00"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Domain":1,"Region":1,"Compositional bias":1,"Non-terminal residue":1},"uniParcId":"UPI0004620E1C"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8QDD7","uniProtkbId":"A0ACI8QDD7_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000541649.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000541649.1"}],"value":"Cadherin 11"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000541649.1"}],"value":"CDH11"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004357"}],"value":"Cadherins are calcium-dependent cell adhesion proteins"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003318"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003318"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":423,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5051454122"},{"type":"Transmembrane","location":{"start":{"value":246,"modifier":"EXACT"},"end":{"value":267,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":79,"modifier":"EXACT"},"end":{"value":159,"modifier":"EXACT"}},"description":"Cadherin","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50268"}]},{"type":"Domain","location":{"start":{"value":174,"modifier":"EXACT"},"end":{"value":236,"modifier":"EXACT"}},"description":"Cadherin","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50268"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022837"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00043"}],"id":"KW-0106","category":"Ligand","name":"Calcium"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022889"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003318"}],"id":"KW-0130","category":"Biological process","name":"Cell adhesion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022685"}],"id":"KW-0165","category":"PTM","name":"Cleavage on pair of basic residues"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8QDD7"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8QDD7"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003318"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000541649.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000541649.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15616553","citationType":"journal article","authors":["Martin J.","Han C.","Gordon L.A.","Terry A.","Prabhakar S.","She X.","Xie G.","Hellsten U.","Chan Y.M.","Altherr M.","Couronne O.","Aerts A.","Bajorek E.","Black S.","Blumer H.","Branscomb E.","Brown N.C.","Bruno W.J.","Buckingham J.M.","Callen D.F.","Campbell C.S.","Campbell M.L.","Campbell E.W.","Caoile C.","Challacombe J.F.","Chasteen L.A.","Chertkov O.","Chi H.C.","Christensen M.","Clark L.M.","Cohn J.D.","Denys M.","Detter J.C.","Dickson M.","Dimitrijevic-Bussod M.","Escobar J.","Fawcett J.J.","Flowers D.","Fotopulos D.","Glavina T.","Gomez M.","Gonzales E.","Goodstein D.","Goodwin L.A.","Grady D.L.","Grigoriev I.","Groza M.","Hammon N.","Hawkins T.","Haydu L.","Hildebrand C.E.","Huang W.","Israni S.","Jett J.","Jewett P.B.","Kadner K.","Kimball H.","Kobayashi A.","Krawczyk M.C.","Leyba T.","Longmire J.L.","Lopez F.","Lou Y.","Lowry S.","Ludeman T.","Manohar C.F.","Mark G.A.","McMurray K.L.","Meincke L.J.","Morgan J.","Moyzis R.K.","Mundt M.O.","Munk A.C.","Nandkeshwar R.D.","Pitluck S.","Pollard M.","Predki P.","Parson-Quintana B.","Ramirez L.","Rash S.","Retterer J.","Ricke D.O.","Robinson D.L.","Rodriguez A.","Salamov A.","Saunders E.H.","Scott D.","Shough T.","Stallings R.L.","Stalvey M.","Sutherland R.D.","Tapia R.","Tesmer J.G.","Thayer N.","Thompson L.S.","Tice H.","Torney D.C.","Tran-Gyamfi M.","Tsai M.","Ulanovsky L.E.","Ustaszewska A.","Vo N.","White P.S.","Williams A.L.","Wills P.L.","Wu J.R.","Wu K.","Yang J.","Dejong P.","Bruce D.","Doggett N.A.","Deaven L.","Schmutz J.","Grimwood J.","Richardson P.","Rokhsar D.S.","Eichler E.E.","Gilna P.","Lucas S.M.","Myers R.M.","Rubin E.M.","Pennacchio L.A."],"citationCrossReferences":[{"database":"PubMed","id":"15616553"},{"database":"DOI","id":"10.1038/nature03187"}],"title":"The sequence and analysis of duplication-rich human chromosome 16.","publicationDate":"2004","journal":"Nature","firstPage":"988","lastPage":"994","volume":"432"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000541649.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000541649.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC010533","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC137643","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000871590.1","properties":[{"key":"ProteinId","value":"ENSP00000541649.1"},{"key":"GeneId","value":"ENSG00000140937.15"}]},{"database":"HGNC","id":"HGNC:1750","properties":[{"key":"GeneName","value":"CDH11"}]},{"database":"OpenTargets","id":"ENSG00000140937","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000153691","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 16"}]},{"database":"CDD","id":"cd11304","properties":[{"key":"EntryName","value":"Cadherin_repeat"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"4.10.900.10:FF:000001","properties":[{"key":"EntryName","value":"Cadherin 2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.60:FF:000009","properties":[{"key":"EntryName","value":"Cadherin 24"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.60","properties":[{"key":"EntryName","value":"Cadherins"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"4.10.900.10","properties":[{"key":"EntryName","value":"TCF3-CBD (Catenin binding domain)"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR039808","properties":[{"key":"EntryName","value":"Cadherin"}]},{"database":"InterPro","id":"IPR002126","properties":[{"key":"EntryName","value":"Cadherin-like_dom"}]},{"database":"InterPro","id":"IPR015919","properties":[{"key":"EntryName","value":"Cadherin-like_sf"}]},{"database":"InterPro","id":"IPR020894","properties":[{"key":"EntryName","value":"Cadherin_CS"}]},{"database":"InterPro","id":"IPR000233","properties":[{"key":"EntryName","value":"Cadherin_Y-type_LIR"}]},{"database":"InterPro","id":"IPR027397","properties":[{"key":"EntryName","value":"Catenin-bd_sf"}]},{"database":"PANTHER","id":"PTHR24027:SF85","properties":[{"key":"EntryName","value":"CADHERIN-11"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR24027","properties":[{"key":"EntryName","value":"CADHERIN-23"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01049","properties":[{"key":"EntryName","value":"CADH_Y-type_LIR"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00028","properties":[{"key":"EntryName","value":"Cadherin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00205","properties":[{"key":"EntryName","value":"CADHERIN"}]},{"database":"SMART","id":"SM00112","properties":[{"key":"EntryName","value":"CA"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF49313","properties":[{"key":"EntryName","value":"Cadherin-like"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS00232","properties":[{"key":"EntryName","value":"CADHERIN_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50268","properties":[{"key":"EntryName","value":"CADHERIN_2"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MKENYCLQAALVCLGMLCHSHAFAPERRGHLRPSFHGHHEKGKEGQVLQRSKRGWVWNQFFVIEEYTGPDPVLVGRLHSDIDSGDGNIKYILSGEGAGTIFVIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTNRPLEPPSEFIVKVQDINDNPPEFLHETYHANVPERSNVDNTAGVYARRGGFSRQKQDLYLLPIVISDGGIPPMSSTNTLTIKVCGCDVNGALLSCNAEAYILNAGLSTGALIAILACIVILLVIVVLFVTLRRQKKEPLIVFEEEDVRENIITYDDEGGGEEDTEAFDIATLQNPDGINGFIPRKDIKPEYQYMPRPGLRPAPNSVDVDDFINTRIQEADNDPTAPPYDSIQIYGYEGRGSVAGSLSSLESATTDSDLDYDYLQNWGPRFKKLADLYGSKDTFDDDS","length":423,"molWeight":46961,"crc64":"EFA76B4D899FAA4B","md5":"155BBCBAA69A3AC2A31C9838AD675FB0"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Transmembrane":1,"Domain":2},"uniParcId":"UPI004031DB6D"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"H3BQB5","uniProtkbId":"H3BQB5_HUMAN","entryAudit":{"firstPublicDate":"2012-04-18","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2012-04-18","entryVersion":62,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000455697.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000455697.1"}],"value":"Cadherin 11"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000455697.1"}],"value":"CDH11"}}],"features":[{"type":"Non-terminal residue","location":{"start":{"value":34,"modifier":"EXACT"},"end":{"value":34,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000455697.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000455697.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000455697.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15616553","citationType":"journal article","authors":["Martin J.","Han C.","Gordon L.A.","Terry A.","Prabhakar S.","She X.","Xie G.","Hellsten U.","Chan Y.M.","Altherr M.","Couronne O.","Aerts A.","Bajorek E.","Black S.","Blumer H.","Branscomb E.","Brown N.C.","Bruno W.J.","Buckingham J.M.","Callen D.F.","Campbell C.S.","Campbell M.L.","Campbell E.W.","Caoile C.","Challacombe J.F.","Chasteen L.A.","Chertkov O.","Chi H.C.","Christensen M.","Clark L.M.","Cohn J.D.","Denys M.","Detter J.C.","Dickson M.","Dimitrijevic-Bussod M.","Escobar J.","Fawcett J.J.","Flowers D.","Fotopulos D.","Glavina T.","Gomez M.","Gonzales E.","Goodstein D.","Goodwin L.A.","Grady D.L.","Grigoriev I.","Groza M.","Hammon N.","Hawkins T.","Haydu L.","Hildebrand C.E.","Huang W.","Israni S.","Jett J.","Jewett P.B.","Kadner K.","Kimball H.","Kobayashi A.","Krawczyk M.C.","Leyba T.","Longmire J.L.","Lopez F.","Lou Y.","Lowry S.","Ludeman T.","Manohar C.F.","Mark G.A.","McMurray K.L.","Meincke L.J.","Morgan J.","Moyzis R.K.","Mundt M.O.","Munk A.C.","Nandkeshwar R.D.","Pitluck S.","Pollard M.","Predki P.","Parson-Quintana B.","Ramirez L.","Rash S.","Retterer J.","Ricke D.O.","Robinson D.L.","Rodriguez A.","Salamov A.","Saunders E.H.","Scott D.","Shough T.","Stallings R.L.","Stalvey M.","Sutherland R.D.","Tapia R.","Tesmer J.G.","Thayer N.","Thompson L.S.","Tice H.","Torney D.C.","Tran-Gyamfi M.","Tsai M.","Ulanovsky L.E.","Ustaszewska A.","Vo N.","White P.S.","Williams A.L.","Wills P.L.","Wu J.R.","Wu K.","Yang J.","Dejong P.","Bruce D.","Doggett N.A.","Deaven L.","Schmutz J.","Grimwood J.","Richardson P.","Rokhsar D.S.","Eichler E.E.","Gilna P.","Lucas S.M.","Myers R.M.","Rubin E.M.","Pennacchio L.A."],"citationCrossReferences":[{"database":"PubMed","id":"15616553"},{"database":"DOI","id":"10.1038/nature03187"}],"title":"The sequence and analysis of duplication-rich human chromosome 16.","publicationDate":"2004","journal":"Nature","firstPage":"988","lastPage":"994","volume":"432"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000455697.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000455697.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC010533","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC137643","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"H3BQB5","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"H3BQB5","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"4584","properties":[{"key":"antibodies","value":"857 antibodies from 40 providers"}]},{"database":"Ensembl","id":"ENST00000562882.5","properties":[{"key":"ProteinId","value":"ENSP00000455697.1"},{"key":"GeneId","value":"ENSG00000140937.15"}]},{"database":"UCSC","id":"uc059vgr.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:1750","properties":[{"key":"GeneName","value":"CDH11"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000140937","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000153691","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_3379472_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"ERYFVIN","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"8188793at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"CDH11","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 16"}]},{"database":"Bgee","id":"ENSG00000140937","properties":[{"key":"ExpressionPatterns","value":"Expressed in periodontal ligament and 195 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"H3BQB5","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]}],"sequence":{"value":"MKENYCLQAALVCLGMLCHSHAFAPERRGHLRPS","length":34,"molWeight":3841,"crc64":"8C9F1E830E1C78A3","md5":"0A38C1CBFCD53AABD91C4B54891D80DA"},"extraAttributes":{"countByFeatureType":{"Non-terminal residue":1},"uniParcId":"UPI0002466E98"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"H3BPQ2","uniProtkbId":"H3BPQ2_HUMAN","entryAudit":{"firstPublicDate":"2012-04-18","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2012-04-18","entryVersion":66,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000455420.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000455420.1"}],"value":"Cadherin 11"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000455420.1"}],"value":"CDH11"}}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":70,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5003581457"},{"type":"Non-terminal residue","location":{"start":{"value":70,"modifier":"EXACT"},"end":{"value":70,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000455420.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"H3BPQ2"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000455420.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000455420.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15616553","citationType":"journal article","authors":["Martin J.","Han C.","Gordon L.A.","Terry A.","Prabhakar S.","She X.","Xie G.","Hellsten U.","Chan Y.M.","Altherr M.","Couronne O.","Aerts A.","Bajorek E.","Black S.","Blumer H.","Branscomb E.","Brown N.C.","Bruno W.J.","Buckingham J.M.","Callen D.F.","Campbell C.S.","Campbell M.L.","Campbell E.W.","Caoile C.","Challacombe J.F.","Chasteen L.A.","Chertkov O.","Chi H.C.","Christensen M.","Clark L.M.","Cohn J.D.","Denys M.","Detter J.C.","Dickson M.","Dimitrijevic-Bussod M.","Escobar J.","Fawcett J.J.","Flowers D.","Fotopulos D.","Glavina T.","Gomez M.","Gonzales E.","Goodstein D.","Goodwin L.A.","Grady D.L.","Grigoriev I.","Groza M.","Hammon N.","Hawkins T.","Haydu L.","Hildebrand C.E.","Huang W.","Israni S.","Jett J.","Jewett P.B.","Kadner K.","Kimball H.","Kobayashi A.","Krawczyk M.C.","Leyba T.","Longmire J.L.","Lopez F.","Lou Y.","Lowry S.","Ludeman T.","Manohar C.F.","Mark G.A.","McMurray K.L.","Meincke L.J.","Morgan J.","Moyzis R.K.","Mundt M.O.","Munk A.C.","Nandkeshwar R.D.","Pitluck S.","Pollard M.","Predki P.","Parson-Quintana B.","Ramirez L.","Rash S.","Retterer J.","Ricke D.O.","Robinson D.L.","Rodriguez A.","Salamov A.","Saunders E.H.","Scott D.","Shough T.","Stallings R.L.","Stalvey M.","Sutherland R.D.","Tapia R.","Tesmer J.G.","Thayer N.","Thompson L.S.","Tice H.","Torney D.C.","Tran-Gyamfi M.","Tsai M.","Ulanovsky L.E.","Ustaszewska A.","Vo N.","White P.S.","Williams A.L.","Wills P.L.","Wu J.R.","Wu K.","Yang J.","Dejong P.","Bruce D.","Doggett N.A.","Deaven L.","Schmutz J.","Grimwood J.","Richardson P.","Rokhsar D.S.","Eichler E.E.","Gilna P.","Lucas S.M.","Myers R.M.","Rubin E.M.","Pennacchio L.A."],"citationCrossReferences":[{"database":"PubMed","id":"15616553"},{"database":"DOI","id":"10.1038/nature03187"}],"title":"The sequence and analysis of duplication-rich human chromosome 16.","publicationDate":"2004","journal":"Nature","firstPage":"988","lastPage":"994","volume":"432"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000455420.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000455420.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC010533","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC137643","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"H3BPQ2","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"H3BPQ2","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"4584","properties":[{"key":"antibodies","value":"857 antibodies from 40 providers"}]},{"database":"Ensembl","id":"ENST00000562998.1","properties":[{"key":"ProteinId","value":"ENSP00000455420.1"},{"key":"GeneId","value":"ENSG00000140937.15"}]},{"database":"UCSC","id":"uc059vgo.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:1750","properties":[{"key":"GeneName","value":"CDH11"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000140937","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000153691","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"ERYFVIN","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"8188793at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"CDH11","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 16"}]},{"database":"Bgee","id":"ENSG00000140937","properties":[{"key":"ExpressionPatterns","value":"Expressed in periodontal ligament and 195 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"H3BPQ2","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]}],"sequence":{"value":"MKENYCLQAALVCLGMLCHSHAFAPERRGHLRPSFHGHHEKGKEGQVLQRSKRGWVWNQFFVIEEYTGPD","length":70,"molWeight":8150,"crc64":"1CF63D362885A54E","md5":"D6814AAEF33FCCCC72A4600B82BF8C43"},"extraAttributes":{"countByFeatureType":{"Signal":1,"Chain":1,"Non-terminal residue":1},"uniParcId":"UPI0002466E95"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"H3BQH2","uniProtkbId":"H3BQH2_HUMAN","entryAudit":{"firstPublicDate":"2012-04-18","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2012-04-18","entryVersion":84,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000455779.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000455779.1"}],"value":"Cadherin 11"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000455779.1"}],"value":"CDH11"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004370"}],"value":"Membrane","id":"SL-0162"}}]}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":222,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5003580996"},{"type":"Domain","location":{"start":{"value":79,"modifier":"EXACT"},"end":{"value":159,"modifier":"EXACT"}},"description":"Cadherin","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50268"}]},{"type":"Domain","location":{"start":{"value":160,"modifier":"EXACT"},"end":{"value":219,"modifier":"EXACT"}},"description":"Cadherin","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50268"}]},{"type":"Non-terminal residue","location":{"start":{"value":222,"modifier":"EXACT"},"end":{"value":222,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000455779.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022837"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00043"}],"id":"KW-0106","category":"Ligand","name":"Calcium"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022889"}],"id":"KW-0130","category":"Biological process","name":"Cell adhesion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"H3BQH2"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"H3BQH2"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000455779.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000455779.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15616553","citationType":"journal article","authors":["Martin J.","Han C.","Gordon L.A.","Terry A.","Prabhakar S.","She X.","Xie G.","Hellsten U.","Chan Y.M.","Altherr M.","Couronne O.","Aerts A.","Bajorek E.","Black S.","Blumer H.","Branscomb E.","Brown N.C.","Bruno W.J.","Buckingham J.M.","Callen D.F.","Campbell C.S.","Campbell M.L.","Campbell E.W.","Caoile C.","Challacombe J.F.","Chasteen L.A.","Chertkov O.","Chi H.C.","Christensen M.","Clark L.M.","Cohn J.D.","Denys M.","Detter J.C.","Dickson M.","Dimitrijevic-Bussod M.","Escobar J.","Fawcett J.J.","Flowers D.","Fotopulos D.","Glavina T.","Gomez M.","Gonzales E.","Goodstein D.","Goodwin L.A.","Grady D.L.","Grigoriev I.","Groza M.","Hammon N.","Hawkins T.","Haydu L.","Hildebrand C.E.","Huang W.","Israni S.","Jett J.","Jewett P.B.","Kadner K.","Kimball H.","Kobayashi A.","Krawczyk M.C.","Leyba T.","Longmire J.L.","Lopez F.","Lou Y.","Lowry S.","Ludeman T.","Manohar C.F.","Mark G.A.","McMurray K.L.","Meincke L.J.","Morgan J.","Moyzis R.K.","Mundt M.O.","Munk A.C.","Nandkeshwar R.D.","Pitluck S.","Pollard M.","Predki P.","Parson-Quintana B.","Ramirez L.","Rash S.","Retterer J.","Ricke D.O.","Robinson D.L.","Rodriguez A.","Salamov A.","Saunders E.H.","Scott D.","Shough T.","Stallings R.L.","Stalvey M.","Sutherland R.D.","Tapia R.","Tesmer J.G.","Thayer N.","Thompson L.S.","Tice H.","Torney D.C.","Tran-Gyamfi M.","Tsai M.","Ulanovsky L.E.","Ustaszewska A.","Vo N.","White P.S.","Williams A.L.","Wills P.L.","Wu J.R.","Wu K.","Yang J.","Dejong P.","Bruce D.","Doggett N.A.","Deaven L.","Schmutz J.","Grimwood J.","Richardson P.","Rokhsar D.S.","Eichler E.E.","Gilna P.","Lucas S.M.","Myers R.M.","Rubin E.M.","Pennacchio L.A."],"citationCrossReferences":[{"database":"PubMed","id":"15616553"},{"database":"DOI","id":"10.1038/nature03187"}],"title":"The sequence and analysis of duplication-rich human chromosome 16.","publicationDate":"2004","journal":"Nature","firstPage":"988","lastPage":"994","volume":"432"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000455779.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000455779.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC010533","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC137643","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"H3BQH2","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"H3BQH2","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"H3BQH2","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"41784","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"4584","properties":[{"key":"antibodies","value":"857 antibodies from 40 providers"}]},{"database":"Ensembl","id":"ENST00000567934.5","properties":[{"key":"ProteinId","value":"ENSP00000455779.1"},{"key":"GeneId","value":"ENSG00000140937.15"}]},{"database":"UCSC","id":"uc010vio.2","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:1750","properties":[{"key":"GeneName","value":"CDH11"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000140937","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000153691","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_098327_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"ERYFVIN","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"8188793at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"CDH11","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 16"}]},{"database":"Bgee","id":"ENSG00000140937","properties":[{"key":"ExpressionPatterns","value":"Expressed in periodontal ligament and 195 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"H3BQH2","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0005509","properties":[{"key":"GoTerm","value":"F:calcium ion binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0007156","properties":[{"key":"GoTerm","value":"P:homophilic cell-cell adhesion"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd11304","properties":[{"key":"EntryName","value":"Cadherin_repeat"},{"key":"MatchStatus","value":"2"}]},{"database":"FunFam","id":"2.60.40.60:FF:000009","properties":[{"key":"EntryName","value":"Cadherin 24"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.60","properties":[{"key":"EntryName","value":"Cadherins"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR039808","properties":[{"key":"EntryName","value":"Cadherin"}]},{"database":"InterPro","id":"IPR002126","properties":[{"key":"EntryName","value":"Cadherin-like_dom"}]},{"database":"InterPro","id":"IPR015919","properties":[{"key":"EntryName","value":"Cadherin-like_sf"}]},{"database":"InterPro","id":"IPR020894","properties":[{"key":"EntryName","value":"Cadherin_CS"}]},{"database":"PANTHER","id":"PTHR24027:SF85","properties":[{"key":"EntryName","value":"CADHERIN-11"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR24027","properties":[{"key":"EntryName","value":"CADHERIN-23"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00028","properties":[{"key":"EntryName","value":"Cadherin"},{"key":"MatchStatus","value":"2"}]},{"database":"PRINTS","id":"PR00205","properties":[{"key":"EntryName","value":"CADHERIN"}]},{"database":"SMART","id":"SM00112","properties":[{"key":"EntryName","value":"CA"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF49313","properties":[{"key":"EntryName","value":"Cadherin-like"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS00232","properties":[{"key":"EntryName","value":"CADHERIN_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50268","properties":[{"key":"EntryName","value":"CADHERIN_2"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MKENYCLQAALVCLGMLCHSHAFAPERRGHLRPSFHGHHEKGKEGQVLQRSKRGWVWNQFFVIEEYTGPDPVLVGRLHSDIDSGDGNIKYILSGEGAGTIFVIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTNRPLEPPSEFIVKVQDINDNPPEFLHETYHANVPERSNVGTSVIQVTASDADDPTYGNSAKLVYSILEGQPYFSVEAQTGIIRTALP","length":222,"molWeight":24731,"crc64":"3AEBE84F866CC39A","md5":"8A8679323ECEDF02B94119C8D3ED4BD1"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":2,"Non-terminal residue":1},"uniParcId":"UPI0002466E94"}}]}