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CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12853576"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14500983"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2784196"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"6605969"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9177355"}],"value":"Forms disulfide-linked heterodimers with CD8B at the cell surface. Also forms homodimers in several cell types including NK-cells or peripheral blood T-lymphocytes. Interacts with the MHC class I HLA-A/B2M dimer. One HLA-A molecule (mainly via nonpolymorphic alpha-3 domain) interacts with one CD8A homodimer (via CDR-like loop) (PubMed:2784196, PubMed:9177355). Interacts with LCK in a zinc-dependent manner. 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