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Plays a role in TLR9 trafficking to acidified CpG-containing compartments by controlling interaction between TLR9 and VAMP3 and subsequent myddosome assembly (By similarity). Inhibits LPS-induced inflammatory response by preventing binding of LPS to TLR4 on the cell surface (PubMed:36945827). Plays a role in the activation of macrophages into anti-inflammatory phenotypes (By similarity). Independently of Toll-like receptor (TLR) signaling, is recruited to pathogen-containing phagosomes prior to fusion with lysosomes and thereby participates in antigen presentation (By similarity). Also acts to control angiogenesis and switch angiogenic milieu to quiescent state by binding and sequestering VEGFA and PDGFB to inhibit the signaling they trigger via their respective cell surface receptor (PubMed:34530889)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P40237"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10985391"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12750295"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15557282"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15677461"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17560548"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19497983"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24623721"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34530889"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8757325"}],"value":"Forms homooligomers (PubMed:24623721). Interacts directly with IGSF8 (PubMed:12750295). Interacts with EGFR (PubMed:10985391, PubMed:35538033). Interacts with VEGFA and PDGFB (PubMed:34530889). Interacts with ITGA4 (PubMed:8757325). Interacts with ITGA6; this interaction reduces ITGA6 cell surface expression (PubMed:15557282). Interacts with ITGB1 (PubMed:8757325). Interacts with TLR4; this interaction inhibits TLR4-mediated signaling pathway (PubMed:36945827). Interacts with TLR9 (By similarity). 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