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Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P41731"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16917503"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19640571"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21962903"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23632027"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24635319"}],"value":"Interacts with TIMP1 and ITGB1 and recruits TIMP1 to ITGB1 (PubMed:16917503, PubMed:24635319). Interacts with CD9. Identified in a complex with CD9 and ITGB3 (PubMed:19640571). Interacts with PMEL (PubMed:21962903). Interacts with KDR/VEGFR2; identified in a complex with ITGB1 and KDR/VEGFR2 and is required to recruit KDR to ITGB1 complexes (PubMed:23632027). Interacts with SYT7 (By similarity)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P08962","intActId":"EBI-762053"},"interactantTwo":{"uniProtKBAccession":"P01033","geneName":"TIMP1","intActId":"EBI-712536"},"numberOfExperiments":8,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P08962","intActId":"EBI-762053"},"interactantTwo":{"uniProtKBAccession":"Q96HE8","geneName":"TMEM80","intActId":"EBI-11742770"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P08962","intActId":"EBI-762053"},"interactantTwo":{"uniProtKBAccession":"P04578","geneName":"env","chainId":"PRO_0000038428","intActId":"EBI-6179711"},"numberOfExperiments":4,"organismDiffer":true}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10793155"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21962903"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7682577"}],"value":"Also found in Weibel-Palade bodies of endothelial cells (PubMed:10793155). Located in platelet dense granules (PubMed:7682577). Detected in a subset of pre-melanosomes. Detected on intralumenal vesicles (ILVs) within multivesicular bodies (PubMed:21962903)"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15351990"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19640571"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23632027"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000255"}],"value":"Multi-pass membrane protein","id":"SL-9909"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17897319"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19640571"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1993697"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22431521"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23632027"}],"value":"Lysosome membrane","id":"SL-0157"},"topology":{"evidences":[{"evidenceCode":"ECO:0000255"}],"value":"Multi-pass membrane protein","id":"SL-9909"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10793155"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23632027"}],"value":"Late endosome membrane","id":"SL-0151"},"topology":{"evidences":[{"evidenceCode":"ECO:0000255"}],"value":"Multi-pass membrane protein","id":"SL-9909"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21962903"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38682696"}],"value":"Endosome, multivesicular body","id":"SL-0174"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21962903"}],"value":"Melanosome","id":"SL-0161"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22660413"}],"value":"Secreted, extracellular exosome","id":"SL-0466"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16917503"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23632027"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24635319"}],"value":"Cell surface","id":"SL-0310"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["P08962-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["P08962-2"],"sequenceIds":["VSP_045300"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"isoformIds":["P08962-3"],"sequenceIds":["VSP_046996"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19640571"}],"value":"Detected in platelets (at protein level). 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