{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P15529","secondaryAccessions":["A0T1T0","A0T1T1","A0T1T2","Q15429","Q53GV9","Q5HY94","Q5VWS6","Q5VWS7","Q5VWS8","Q5VWS9","Q5VWT0","Q5VWT1","Q5VWT2","Q6N0A1","Q7Z3R5","Q9NNW2","Q9NNW3","Q9NNW4","Q9UCJ4"],"uniProtkbId":"MCP_HUMAN","entryAudit":{"firstPublicDate":"1990-04-01","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2004-01-16","entryVersion":253,"sequenceVersion":3},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Membrane cofactor protein"}},"alternativeNames":[{"fullName":{"value":"TLX"}},{"fullName":{"value":"Trophoblast leukocyte common antigen"}}],"cdAntigenNames":[{"value":"CD46"}],"flag":"Precursor"},"genes":[{"geneName":{"value":"CD46"},"synonyms":[{"value":"MCP"},{"value":"MIC10"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10843656"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12540904"}],"value":"Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity"}],"commentType":"FUNCTION"},{"texts":[{"value":"(Microbial infection) A number of viral and bacterial pathogens seem to bind MCP in order to exploit its immune regulation property and directly induce an immunosuppressive phenotype in T-cells"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12915534"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14566335"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15047806"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15078926"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15919905"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16254377"}],"value":"(Microbial infection) Acts as a receptor for Adenovirus subgroup B2 and Ad3"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10972291"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20010840"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7534417"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8371352"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8402913"}],"value":"(Microbial infection) Acts as a receptor for cultured Measles virus"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12663806"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12724329"}],"value":"(Microbial infection) Acts as a receptor for Herpesvirus 6/HHV-6"}],"commentType":"FUNCTION"},{"texts":[{"value":"(Microbial infection) May act as a receptor for pathogenic bacteria Neisseria and Streptococcus pyogenes (PubMed:11260136, PubMed:11971006, PubMed:7708671, PubMed:9379894)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32581096"}],"value":"(Microbial infection) Plays a minor role in fiber protein-mediated human adenovirus 55 infection; via its interaction with fiber protein (PubMed:32581096). Plays a minor role in fiber protein-mediated human adenovirus 14a infection (PubMed:32581096)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1717583"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"3260937"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7884872"}],"value":"Interacts with C3b (PubMed:1717583, PubMed:3260937). Interacts with C4b (PubMed:1717583). Interacts with moesin/MSN (PubMed:7884872)"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10972291"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20010840"}],"value":"(Microbial infection) Interacts (via N-terminus) with measles virus H protein; this interaction allows attachment and viral entry of vaccine and laboratory-adapted strains"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12663806"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12724329"}],"value":"(Microbial infection) Interacts with human herpesvirus 6 GH protein (PubMed:12663806, PubMed:12724329)"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12915534"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14566335"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15047806"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15078926"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15919905"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16254377"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32581096"}],"value":"(Microbial infection) Interacts with human adenovirus B/D fiber protein (PubMed:12915534, PubMed:14566335, PubMed:15047806, PubMed:15078926, PubMed:15919905, PubMed:16254377). Interacts with human adenovirus 55 fiber protein; the interaction facilitates infection of host cells (PubMed:32581096)"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11260136"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11971006"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7708671"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9379894"}],"value":"(Microbial infection) Binds to Streptococcus pyogenes M protein and to type IV pili from Neisseria (PubMed:11260136, PubMed:11971006, PubMed:7708671, 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The complete sequences of the isoforms are not known. Isoforms are classified as alpha (isoform C and isoform D), beta (isoform E and isoform F), gamma (isoform A and isoform B) and delta (isoform N). Isoforms gamma are preferentially expressed in EBV-B cells and leukemic cells. Isoforms alpha (66 kDa) and isoforms beta (56 kDa) are found in all tissues except sperm. Isoform delta is expressed in spermatozoa. The exon 9 is specifically deleted in some placentae isoforms. All tissues differentially splice exon 13."}]}},{"texts":[{"value":"Expressed by all cells except erythrocytes"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"value":"Sushi domains 1 and 2 are required for interaction with human adenovirus B PIV/FIBER protein and with Measles virus H protein. Sushi domains 2 and 3 are required for Herpesvirus 6 binding. Sushi domain 3 is required for Neisseria binding. 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