{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P15529","secondaryAccessions":["A0T1T0","A0T1T1","A0T1T2","Q15429","Q53GV9","Q5HY94","Q5VWS6","Q5VWS7","Q5VWS8","Q5VWS9","Q5VWT0","Q5VWT1","Q5VWT2","Q6N0A1","Q7Z3R5","Q9NNW2","Q9NNW3","Q9NNW4","Q9UCJ4"],"uniProtkbId":"MCP_HUMAN","entryAudit":{"firstPublicDate":"1990-04-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2004-01-16","entryVersion":252,"sequenceVersion":3},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Membrane cofactor protein"}},"alternativeNames":[{"fullName":{"value":"TLX"}},{"fullName":{"value":"Trophoblast leukocyte common antigen"}}],"cdAntigenNames":[{"value":"CD46"}],"flag":"Precursor"},"genes":[{"geneName":{"value":"CD46"},"synonyms":[{"value":"MCP"},{"value":"MIC10"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10843656"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12540904"}],"value":"Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity"}],"commentType":"FUNCTION"},{"texts":[{"value":"(Microbial infection) A number of viral and bacterial pathogens seem to bind MCP in order to exploit its immune regulation property and directly induce an immunosuppressive phenotype in T-cells"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12915534"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14566335"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15047806"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15078926"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15919905"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16254377"}],"value":"(Microbial infection) Acts as a receptor for Adenovirus subgroup B2 and Ad3"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10972291"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20010840"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7534417"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8371352"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8402913"}],"value":"(Microbial infection) Acts as a receptor for cultured Measles virus"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12663806"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12724329"}],"value":"(Microbial infection) Acts as a receptor for Herpesvirus 6/HHV-6"}],"commentType":"FUNCTION"},{"texts":[{"value":"(Microbial infection) May act as a receptor for pathogenic bacteria Neisseria and Streptococcus pyogenes (PubMed:11260136, PubMed:11971006, PubMed:7708671, PubMed:9379894)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32581096"}],"value":"(Microbial infection) Plays a minor role in fiber protein-mediated human adenovirus 55 infection; via its interaction with fiber protein (PubMed:32581096). Plays a minor role in fiber protein-mediated human adenovirus 14a infection (PubMed:32581096)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1717583"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"3260937"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7884872"}],"value":"Interacts with C3b (PubMed:1717583, PubMed:3260937). Interacts with C4b (PubMed:1717583). Interacts with moesin/MSN (PubMed:7884872)"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10972291"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20010840"}],"value":"(Microbial infection) Interacts (via N-terminus) with measles virus H protein; this interaction allows attachment and viral entry of vaccine and laboratory-adapted strains"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12663806"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12724329"}],"value":"(Microbial infection) Interacts with human herpesvirus 6 GH protein (PubMed:12663806, PubMed:12724329)"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12915534"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14566335"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15047806"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15078926"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15919905"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16254377"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32581096"}],"value":"(Microbial infection) Interacts with human adenovirus B/D fiber protein (PubMed:12915534, PubMed:14566335, PubMed:15047806, PubMed:15078926, PubMed:15919905, PubMed:16254377). Interacts with human adenovirus 55 fiber protein; the interaction facilitates infection of host cells (PubMed:32581096)"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11260136"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11971006"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7708671"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9379894"}],"value":"(Microbial infection) Binds to Streptococcus pyogenes M protein and to type IV pili from Neisseria (PubMed:11260136, PubMed:11971006, PubMed:7708671, PubMed:9379894)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P15529","intActId":"EBI-2623451"},"interactantTwo":{"uniProtKBAccession":"Q99767","geneName":"APBA2","intActId":"EBI-81711"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P15529","intActId":"EBI-2623451"},"interactantTwo":{"uniProtKBAccession":"P01024","geneName":"C3","intActId":"EBI-905851"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P15529","intActId":"EBI-2623451"},"interactantTwo":{"uniProtKBAccession":"Q92796","geneName":"DLG3","intActId":"EBI-80440"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P15529","intActId":"EBI-2623451"},"interactantTwo":{"uniProtKBAccession":"P78352","geneName":"DLG4","intActId":"EBI-80389"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P15529","intActId":"EBI-2623451"},"interactantTwo":{"uniProtKBAccession":"Q68DX3","geneName":"FRMPD2","intActId":"EBI-53993476"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P15529","intActId":"EBI-2623451"},"interactantTwo":{"uniProtKBAccession":"A4D2P6","geneName":"GRID2IP","intActId":"EBI-15893226"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P15529","intActId":"EBI-2623451"},"interactantTwo":{"uniProtKBAccession":"Q9Y3R0","geneName":"GRIP1","intActId":"EBI-5349621"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P15529","intActId":"EBI-2623451"},"interactantTwo":{"uniProtKBAccession":"Q9C0E4","geneName":"GRIP2","intActId":"EBI-949557"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P15529","intActId":"EBI-2623451"},"interactantTwo":{"uniProtKBAccession":"Q14005","geneName":"IL16","intActId":"EBI-2831580"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P15529","intActId":"EBI-2623451"},"interactantTwo":{"uniProtKBAccession":"P78504","geneName":"JAG1","intActId":"EBI-2847071"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P15529","intActId":"EBI-2623451"},"interactantTwo":{"uniProtKBAccession":"Q8TBB1","geneName":"LNX1","intActId":"EBI-739832"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P15529","intActId":"EBI-2623451"},"interactantTwo":{"uniProtKBAccession":"Q8N448","geneName":"LNX2","intActId":"EBI-2340947"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P15529","intActId":"EBI-2623451"},"interactantTwo":{"uniProtKBAccession":"Q86UL8","geneName":"MAGI2","intActId":"EBI-311035"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P15529","intActId":"EBI-2623451"},"interactantTwo":{"uniProtKBAccession":"O75970","geneName":"MPDZ","intActId":"EBI-821405"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P15529","intActId":"EBI-2623451"},"interactantTwo":{"uniProtKBAccession":"Q86UT5","geneName":"NHERF4","intActId":"EBI-8744528"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P15529","intActId":"EBI-2623451"},"interactantTwo":{"uniProtKBAccession":"Q8NI35","geneName":"PATJ","intActId":"EBI-724390"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P15529","intActId":"EBI-2623451"},"interactantTwo":{"uniProtKBAccession":"Q5T2W1","geneName":"PDZK1","intActId":"EBI-349819"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P15529","intActId":"EBI-2623451"},"interactantTwo":{"uniProtKBAccession":"Q14160","geneName":"SCRIB","intActId":"EBI-357345"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P15529","intActId":"EBI-2623451"},"interactantTwo":{"uniProtKBAccession":"Q07157","geneName":"TJP1","intActId":"EBI-79553"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P15529-3","intActId":"EBI-13046140"},"interactantTwo":{"uniProtKBAccession":"Q8TD06","geneName":"AGR3","intActId":"EBI-3925742"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P15529-3","intActId":"EBI-13046140"},"interactantTwo":{"uniProtKBAccession":"Q86W74-2","geneName":"ANKRD46","intActId":"EBI-12109402"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P15529-3","intActId":"EBI-13046140"},"interactantTwo":{"uniProtKBAccession":"O60883","geneName":"GPR37L1","intActId":"EBI-2927498"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P15529-3","intActId":"EBI-13046140"},"interactantTwo":{"uniProtKBAccession":"Q12837","geneName":"POU4F2","intActId":"EBI-17236143"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P15529-3","intActId":"EBI-13046140"},"interactantTwo":{"uniProtKBAccession":"Q9UEU0","geneName":"VTI1B","intActId":"EBI-723716"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"value":"Inner acrosomal membrane of spermatozoa. Internalized upon binding of Measles virus, Herpesvirus 6 or Neisseria gonorrhoeae, which results in an increased susceptibility of infected cells to complement-mediated injury. In cancer cells or cells infected by Neisseria, shedding leads to a soluble peptide"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12112588"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14597734"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15307194"}],"value":"Cytoplasmic vesicle, secretory vesicle, acrosome inner membrane","id":"SL-0004"},"topology":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12112588"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14597734"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15307194"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"A"},"synonyms":[{"value":"no del"},{"value":"ABC1"}],"isoformIds":["P15529-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"B"},"synonyms":[{"value":"del 13"},{"value":"ABC2"}],"isoformIds":["P15529-2"],"sequenceIds":["VSP_001204"],"isoformSequenceStatus":"Described"},{"name":{"value":"C"},"synonyms":[{"value":"del 7"},{"value":"BC1"}],"isoformIds":["P15529-11"],"sequenceIds":["VSP_009174"],"isoformSequenceStatus":"Described"},{"name":{"value":"D"},"synonyms":[{"value":"del 7-13"},{"value":"BC2"}],"isoformIds":["P15529-3"],"sequenceIds":["VSP_009174","VSP_001204"],"isoformSequenceStatus":"Described"},{"name":{"value":"E"},"synonyms":[{"value":"del 7-8"},{"value":"C1"}],"isoformIds":["P15529-12"],"sequenceIds":["VSP_009175"],"isoformSequenceStatus":"Described"},{"name":{"value":"F"},"synonyms":[{"value":"del 7-8-13"},{"value":"C2"}],"isoformIds":["P15529-4"],"sequenceIds":["VSP_009175","VSP_001204"],"isoformSequenceStatus":"Described"},{"name":{"value":"G"},"synonyms":[{"value":"del 9"}],"isoformIds":["P15529-13"],"sequenceIds":["VSP_009177"],"isoformSequenceStatus":"Described"},{"name":{"value":"H"},"synonyms":[{"value":"del 9-13"}],"isoformIds":["P15529-5"],"sequenceIds":["VSP_009177","VSP_001204"],"isoformSequenceStatus":"Described"},{"name":{"value":"I"},"synonyms":[{"value":"del 7-9"}],"isoformIds":["P15529-14"],"sequenceIds":["VSP_009174","VSP_009177"],"isoformSequenceStatus":"Described"},{"name":{"value":"J"},"synonyms":[{"value":"del 7-9-13"}],"isoformIds":["P15529-6"],"sequenceIds":["VSP_009174","VSP_009177","VSP_001204"],"isoformSequenceStatus":"Described"},{"name":{"value":"K"},"synonyms":[{"value":"del 7-8-9"}],"isoformIds":["P15529-15"],"sequenceIds":["VSP_009176"],"isoformSequenceStatus":"Described"},{"name":{"value":"L"},"synonyms":[{"value":"del 7-8-9-13"}],"isoformIds":["P15529-7"],"sequenceIds":["VSP_009176","VSP_001204"],"isoformSequenceStatus":"Described"},{"name":{"value":"M"},"synonyms":[{"value":"del 7-12a-13"}],"isoformIds":["P15529-8"],"sequenceIds":["VSP_009174","VSP_001202","VSP_001203"],"isoformSequenceStatus":"Described"},{"name":{"value":"N"},"synonyms":[{"value":"del 7-8-12-13"}],"isoformIds":["P15529-9"],"sequenceIds":["VSP_009175","VSP_009178"],"isoformSequenceStatus":"Described"},{"name":{"value":"2"},"isoformIds":["P15529-10"],"sequenceIds":["VSP_001201"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"isoformIds":["P15529-16"],"sequenceIds":["VSP_019005","VSP_019006","VSP_001204"],"isoformSequenceStatus":"Described"}],"note":{"texts":[{"value":"Additional isoforms seem to exist. The complete sequences of the isoforms are not known. Isoforms are classified as alpha (isoform C and isoform D), beta (isoform E and isoform F), gamma (isoform A and isoform B) and delta (isoform N). Isoforms gamma are preferentially expressed in EBV-B cells and leukemic cells. Isoforms alpha (66 kDa) and isoforms beta (56 kDa) are found in all tissues except sperm. Isoform delta is expressed in spermatozoa. The exon 9 is specifically deleted in some placentae isoforms. All tissues differentially splice exon 13."}]}},{"texts":[{"value":"Expressed by all cells except erythrocytes"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"value":"Sushi domains 1 and 2 are required for interaction with human adenovirus B PIV/FIBER protein and with Measles virus H protein. Sushi domains 2 and 3 are required for Herpesvirus 6 binding. Sushi domain 3 is required for Neisseria binding. Sushi domains 3 and 4 are required for interaction with Streptococcus pyogenes M protein and are the most important for interaction with C3b and C4b"}],"commentType":"DOMAIN"},{"texts":[{"value":"N-glycosylated on Asn-83; Asn-114 and Asn-273 in most tissues, but probably less N-glycosylated in testis. N-glycosylation on Asn-114 and Asn-273 is required for cytoprotective function. N-glycosylation on Asn-114 is required for Measles virus binding. N-glycosylation on Asn-273 is required for Neisseria binding. N-glycosylation is not required for human adenovirus binding"}],"commentType":"PTM"},{"texts":[{"value":"Extensively O-glycosylated in the Ser/Thr-rich domain. O-glycosylation is required for Neisseria binding but not for Measles virus or human adenovirus binding"}],"commentType":"PTM"},{"texts":[{"value":"In epithelial cells, isoforms B/D/F/H/J/L/3 are phosphorylated by YES1 in response to infection by Neisseria gonorrhoeae; which promotes infectivity. In T-cells, these isoforms may be phosphorylated by LCK"}],"commentType":"PTM"},{"commentType":"DISEASE","disease":{"diseaseId":"Hemolytic uremic syndrome, atypical, 2","diseaseAccession":"DI-02597","acronym":"AHUS2","description":"An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease.","diseaseCrossReference":{"database":"MIM","id":"612922"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14566051"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16386793"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16621965"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20513133"}]},"note":{"texts":[{"value":"Disease susceptibility is associated with variants affecting the gene represented in this entry. Other genes may play a role in modifying the phenotype. Patients with CD46 mutations seem to have an overall better prognosis compared to patients carrying CFH mutations"}]}}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":34,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1479546"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2298462"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"3260937"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8371352"}]},{"type":"Chain","location":{"start":{"value":35,"modifier":"EXACT"},"end":{"value":392,"modifier":"EXACT"}},"description":"Membrane cofactor protein","featureId":"PRO_0000006008"},{"type":"Topological domain","location":{"start":{"value":35,"modifier":"EXACT"},"end":{"value":343,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":344,"modifier":"EXACT"},"end":{"value":366,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":367,"modifier":"EXACT"},"end":{"value":392,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Domain","location":{"start":{"value":35,"modifier":"EXACT"},"end":{"value":96,"modifier":"EXACT"}},"description":"Sushi 1","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00302"}]},{"type":"Domain","location":{"start":{"value":97,"modifier":"EXACT"},"end":{"value":159,"modifier":"EXACT"}},"description":"Sushi 2","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00302"}]},{"type":"Domain","location":{"start":{"value":160,"modifier":"EXACT"},"end":{"value":225,"modifier":"EXACT"}},"description":"Sushi 3","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00302"}]},{"type":"Domain","location":{"start":{"value":226,"modifier":"EXACT"},"end":{"value":285,"modifier":"EXACT"}},"description":"Sushi 4","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00302"}]},{"type":"Region","location":{"start":{"value":291,"modifier":"EXACT"},"end":{"value":328,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":291,"modifier":"EXACT"},"end":{"value":315,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Glycosylation","location":{"start":{"value":83,"modifier":"EXACT"},"end":{"value":83,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","featureId":""},{"type":"Glycosylation","location":{"start":{"value":114,"modifier":"EXACT"},"end":{"value":114,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20010840"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3INB"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3L89"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":163,"modifier":"EXACT"},"end":{"value":163,"modifier":"EXACT"}},"description":"O-linked (GalNAc...) threonine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":273,"modifier":"EXACT"},"end":{"value":273,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","featureId":""},{"type":"Glycosylation","location":{"start":{"value":290,"modifier":"EXACT"},"end":{"value":290,"modifier":"EXACT"}},"description":"O-linked (GalNAc...) serine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":291,"modifier":"EXACT"},"end":{"value":291,"modifier":"EXACT"}},"description":"O-linked (GalNAc...) serine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":292,"modifier":"EXACT"},"end":{"value":292,"modifier":"EXACT"}},"description":"O-linked (GalNAc...) threonine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":298,"modifier":"EXACT"},"end":{"value":298,"modifier":"EXACT"}},"description":"O-linked (GalNAc...) serine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":300,"modifier":"EXACT"},"end":{"value":300,"modifier":"EXACT"}},"description":"O-linked (GalNAc...) serine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":302,"modifier":"EXACT"},"end":{"value":302,"modifier":"EXACT"}},"description":"O-linked (GalNAc...) serine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":303,"modifier":"EXACT"},"end":{"value":303,"modifier":"EXACT"}},"description":"O-linked (GalNAc...) threonine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":304,"modifier":"EXACT"},"end":{"value":304,"modifier":"EXACT"}},"description":"O-linked (GalNAc...) serine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":305,"modifier":"EXACT"},"end":{"value":305,"modifier":"EXACT"}},"description":"O-linked (GalNAc...) serine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":306,"modifier":"EXACT"},"end":{"value":306,"modifier":"EXACT"}},"description":"O-linked (GalNAc...) threonine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":307,"modifier":"EXACT"},"end":{"value":307,"modifier":"EXACT"}},"description":"O-linked (GalNAc...) threonine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":309,"modifier":"EXACT"},"end":{"value":309,"modifier":"EXACT"}},"description":"O-linked (GalNAc...) serine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":312,"modifier":"EXACT"},"end":{"value":312,"modifier":"EXACT"}},"description":"O-linked (GalNAc...) serine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":313,"modifier":"EXACT"},"end":{"value":313,"modifier":"EXACT"}},"description":"O-linked (GalNAc...) serine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":315,"modifier":"EXACT"},"end":{"value":315,"modifier":"EXACT"}},"description":"O-linked (GalNAc...) serine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":320,"modifier":"EXACT"},"end":{"value":320,"modifier":"EXACT"}},"description":"O-linked (GalNAc...) threonine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":326,"modifier":"EXACT"},"end":{"value":326,"modifier":"EXACT"}},"description":"O-linked (GalNAc...) serine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Disulfide bond","location":{"start":{"value":35,"modifier":"EXACT"},"end":{"value":80,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00302"}]},{"type":"Disulfide bond","location":{"start":{"value":64,"modifier":"EXACT"},"end":{"value":94,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00302"}]},{"type":"Disulfide bond","location":{"start":{"value":99,"modifier":"EXACT"},"end":{"value":141,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00302"}]},{"type":"Disulfide bond","location":{"start":{"value":127,"modifier":"EXACT"},"end":{"value":157,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00302"}]},{"type":"Disulfide bond","location":{"start":{"value":162,"modifier":"EXACT"},"end":{"value":210,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00302"}]},{"type":"Disulfide bond","location":{"start":{"value":191,"modifier":"EXACT"},"end":{"value":223,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00302"}]},{"type":"Disulfide bond","location":{"start":{"value":228,"modifier":"EXACT"},"end":{"value":270,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00302"}]},{"type":"Disulfide bond","location":{"start":{"value":256,"modifier":"EXACT"},"end":{"value":283,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00302"}]},{"type":"Alternative sequence","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":33,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000305"}],"featureId":"VSP_019005","alternativeSequence":{"originalSequence":"D","alternativeSequences":["G"]}},{"type":"Alternative sequence","location":{"start":{"value":34,"modifier":"EXACT"},"end":{"value":96,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000305"}],"featureId":"VSP_019006","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":286,"modifier":"EXACT"},"end":{"value":329,"modifier":"EXACT"}},"description":"in isoform K and isoform L","evidences":[{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.6"}],"featureId":"VSP_009176","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":286,"modifier":"EXACT"},"end":{"value":315,"modifier":"EXACT"}},"description":"in isoform E, isoform F and isoform N","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"1711570"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"17974005"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"8418811"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"9659228"},{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.6"}],"featureId":"VSP_009175","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":286,"modifier":"EXACT"},"end":{"value":300,"modifier":"EXACT"}},"description":"in isoform C, isoform D, isoform I, isoform J and isoform M","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"1711570"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"17974005"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"2050389"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"3260937"},{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.6"}],"featureId":"VSP_009174","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":301,"modifier":"EXACT"},"end":{"value":305,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000305"}],"featureId":"VSP_001201","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":316,"modifier":"EXACT"},"end":{"value":329,"modifier":"EXACT"}},"description":"in isoform G, isoform H, isoform I and isoform J","evidences":[{"evidenceCode":"ECO:0000305"}],"featureId":"VSP_009177","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":355,"modifier":"EXACT"},"end":{"value":392,"modifier":"EXACT"}},"description":"in isoform N","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"9659228"}],"featureId":"VSP_009178","alternativeSequence":{"originalSequence":"VVGVAVICVVPYRYLQRRKKKGTYLTDETHREVKFTSL","alternativeSequences":["GKQMVELNMPLTRLNQPLQQSREAE"]}},{"type":"Alternative sequence","location":{"start":{"value":355,"modifier":"EXACT"},"end":{"value":367,"modifier":"EXACT"}},"description":"in isoform M","evidences":[{"evidenceCode":"ECO:0000305"}],"featureId":"VSP_001202","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":368,"modifier":"EXACT"},"end":{"value":392,"modifier":"EXACT"}},"description":"in isoform M","evidences":[{"evidenceCode":"ECO:0000305"}],"featureId":"VSP_001203","alternativeSequence":{"originalSequence":"YLQRRKKKGTYLTDETHREVKFTSL","alternativeSequences":["GKQMVELNMPLTRLNQPLQQSREAE"]}},{"type":"Alternative sequence","location":{"start":{"value":377,"modifier":"EXACT"},"end":{"value":392,"modifier":"EXACT"}},"description":"in isoform B, isoform D, isoform F, isoform H, isoform J, isoform L and isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"1711570"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"17974005"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"3260937"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"8418811"},{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.6"},{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.9"}],"featureId":"VSP_001204","alternativeSequence":{"originalSequence":"TYLTDETHREVKFTSL","alternativeSequences":["KADGGAEYATYQTKSTTPAEQRG"]}},{"type":"Natural variant","location":{"start":{"value":13,"modifier":"EXACT"},"end":{"value":13,"modifier":"EXACT"}},"description":"in dbSNP:rs138843816","featureCrossReferences":[{"database":"dbSNP","id":"rs138843816"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10751138"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.9"}],"featureId":"VAR_026567","alternativeSequence":{"originalSequence":"S","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":35,"modifier":"EXACT"},"end":{"value":35,"modifier":"EXACT"}},"description":"in AHUS2; dbSNP:rs121909591","featureCrossReferences":[{"database":"dbSNP","id":"rs121909591"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16621965"}],"featureId":"VAR_063656","alternativeSequence":{"originalSequence":"C","alternativeSequences":["Y"]}},{"type":"Natural variant","location":{"start":{"value":59,"modifier":"EXACT"},"end":{"value":59,"modifier":"EXACT"}},"description":"in dbSNP:rs780693519","featureCrossReferences":[{"database":"dbSNP","id":"rs780693519"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10751138"}],"featureId":"VAR_026568","alternativeSequence":{"originalSequence":"R","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":165,"modifier":"EXACT"},"end":{"value":165,"modifier":"EXACT"}},"description":"in AHUS2; reduced cell surface expression; dbSNP:rs759136081","featureCrossReferences":[{"database":"dbSNP","id":"rs759136081"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16386793"}],"featureId":"VAR_026569","alternativeSequence":{"originalSequence":"P","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":216,"modifier":"EXACT"},"end":{"value":216,"modifier":"EXACT"}},"description":"in AHUS2; dbSNP:rs1656197837","featureCrossReferences":[{"database":"dbSNP","id":"rs1656197837"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20513133"}],"featureId":"VAR_063657","alternativeSequence":{"originalSequence":"W","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":228,"modifier":"EXACT"},"end":{"value":228,"modifier":"EXACT"}},"description":"in a colorectal cancer sample; somatic mutation","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16959974"}],"featureId":"VAR_035828","alternativeSequence":{"originalSequence":"C","alternativeSequences":["Y"]}},{"type":"Natural variant","location":{"start":{"value":231,"modifier":"EXACT"},"end":{"value":231,"modifier":"EXACT"}},"description":"in AHUS2; dbSNP:rs1271761432","featureCrossReferences":[{"database":"dbSNP","id":"rs1271761432"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20513133"}],"featureId":"VAR_063658","alternativeSequence":{"originalSequence":"P","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":240,"modifier":"EXACT"},"end":{"value":240,"modifier":"EXACT"}},"description":"in AHUS2; no change in cell surface expression but reduced activity; dbSNP:rs121909589","featureCrossReferences":[{"database":"dbSNP","id":"rs121909589"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14566051"}],"featureId":"VAR_026570","alternativeSequence":{"originalSequence":"S","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":266,"modifier":"EXACT"},"end":{"value":266,"modifier":"EXACT"}},"description":"in dbSNP:rs17006830","featureCrossReferences":[{"database":"dbSNP","id":"rs17006830"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.10"}],"featureId":"VAR_022262","alternativeSequence":{"originalSequence":"D","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":271,"modifier":"EXACT"},"end":{"value":272,"modifier":"EXACT"}},"description":"in AHUS2; no cell surface expression","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14566051"}],"featureId":"VAR_026571","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":324,"modifier":"EXACT"},"end":{"value":324,"modifier":"EXACT"}},"description":"in dbSNP:rs41317833","featureCrossReferences":[{"database":"dbSNP","id":"rs41317833"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.10"}],"featureId":"VAR_022263","alternativeSequence":{"originalSequence":"P","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":353,"modifier":"EXACT"},"end":{"value":353,"modifier":"EXACT"}},"description":"in dbSNP:rs35366573","featureCrossReferences":[{"database":"dbSNP","id":"rs35366573"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16959974"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.10"}],"featureId":"VAR_022264","alternativeSequence":{"originalSequence":"A","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":355,"modifier":"EXACT"},"end":{"value":355,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.10"}],"featureId":"VAR_022265","alternativeSequence":{"originalSequence":"V","alternativeSequences":["G"]}},{"type":"Mutagenesis","location":{"start":{"value":83,"modifier":"EXACT"},"end":{"value":83,"modifier":"EXACT"}},"description":"No effect on cytoprotective function. No effect on Neisseria binding. No effect on Measles virus binding.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11260136"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8764003"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9759896"}],"alternativeSequence":{"originalSequence":"N","alternativeSequences":["Q"]}},{"type":"Mutagenesis","location":{"start":{"value":114,"modifier":"EXACT"},"end":{"value":114,"modifier":"EXACT"}},"description":"Strongly decreases cytoprotective function. Decreases Neisseria binding. Abolishes Measles virus binding.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11260136"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8764003"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9759896"}],"alternativeSequence":{"originalSequence":"N","alternativeSequences":["Q"]}},{"type":"Mutagenesis","location":{"start":{"value":273,"modifier":"EXACT"},"end":{"value":273,"modifier":"EXACT"}},"description":"Strongly decreases cytoprotective function. Abolishes Neisseria binding. No effect on Measles virus binding.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11260136"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8764003"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9759896"}],"alternativeSequence":{"originalSequence":"N","alternativeSequences":["Q"]}},{"type":"Sequence conflict","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":25,"modifier":"EXACT"}},"description":"in Ref. 8; CAE45719","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"V","alternativeSequences":["A"]}},{"type":"Sequence conflict","location":{"start":{"value":108,"modifier":"EXACT"},"end":{"value":108,"modifier":"EXACT"}},"description":"in Ref. 8; CAD97694","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"G","alternativeSequences":["S"]}},{"type":"Sequence conflict","location":{"start":{"value":159,"modifier":"EXACT"},"end":{"value":159,"modifier":"EXACT"}},"description":"in Ref. 8; CAD97694","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["S"]}},{"type":"Sequence conflict","location":{"start":{"value":162,"modifier":"EXACT"},"end":{"value":162,"modifier":"EXACT"}},"description":"in Ref. 8; CAI45983","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["R"]}},{"type":"Helix","location":{"start":{"value":38,"modifier":"EXACT"},"end":{"value":40,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3O8E"}]},{"type":"Beta strand","location":{"start":{"value":42,"modifier":"EXACT"},"end":{"value":48,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3O8E"}]},{"type":"Helix","location":{"start":{"value":49,"modifier":"EXACT"},"end":{"value":51,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3O8E"}]},{"type":"Beta strand","location":{"start":{"value":59,"modifier":"EXACT"},"end":{"value":64,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3O8E"}]},{"type":"Beta strand","location":{"start":{"value":68,"modifier":"EXACT"},"end":{"value":70,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3O8E"}]},{"type":"Beta strand","location":{"start":{"value":72,"modifier":"EXACT"},"end":{"value":74,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3O8E"}]},{"type":"Beta strand","location":{"start":{"value":77,"modifier":"EXACT"},"end":{"value":80,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3O8E"}]},{"type":"Beta strand","location":{"start":{"value":84,"modifier":"EXACT"},"end":{"value":86,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3O8E"}]},{"type":"Helix","location":{"start":{"value":91,"modifier":"EXACT"},"end":{"value":93,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8QK3"}]},{"type":"Beta strand","location":{"start":{"value":94,"modifier":"EXACT"},"end":{"value":96,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3O8E"}]},{"type":"Helix","location":{"start":{"value":99,"modifier":"EXACT"},"end":{"value":105,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3O8E"}]},{"type":"Beta strand","location":{"start":{"value":108,"modifier":"EXACT"},"end":{"value":112,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3O8E"}]},{"type":"Beta strand","location":{"start":{"value":115,"modifier":"EXACT"},"end":{"value":118,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3O8E"}]},{"type":"Beta strand","location":{"start":{"value":122,"modifier":"EXACT"},"end":{"value":127,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3O8E"}]},{"type":"Beta strand","location":{"start":{"value":131,"modifier":"EXACT"},"end":{"value":135,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3O8E"}]},{"type":"Beta strand","location":{"start":{"value":137,"modifier":"EXACT"},"end":{"value":146,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3O8E"}]},{"type":"Beta strand","location":{"start":{"value":148,"modifier":"EXACT"},"end":{"value":152,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3O8E"}]},{"type":"Helix","location":{"start":{"value":153,"modifier":"EXACT"},"end":{"value":155,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3O8E"}]},{"type":"Beta strand","location":{"start":{"value":156,"modifier":"EXACT"},"end":{"value":159,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3O8E"}]},{"type":"Helix","location":{"start":{"value":163,"modifier":"EXACT"},"end":{"value":167,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5FO8"}]},{"type":"Beta strand","location":{"start":{"value":171,"modifier":"EXACT"},"end":{"value":174,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5FO8"}]},{"type":"Beta strand","location":{"start":{"value":183,"modifier":"EXACT"},"end":{"value":191,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5FO8"}]},{"type":"Helix","location":{"start":{"value":192,"modifier":"EXACT"},"end":{"value":194,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5FO8"}]},{"type":"Beta strand","location":{"start":{"value":195,"modifier":"EXACT"},"end":{"value":198,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5FO8"}]},{"type":"Beta strand","location":{"start":{"value":201,"modifier":"EXACT"},"end":{"value":204,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5FO8"}]},{"type":"Beta strand","location":{"start":{"value":206,"modifier":"EXACT"},"end":{"value":210,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5FO8"}]},{"type":"Helix","location":{"start":{"value":212,"modifier":"EXACT"},"end":{"value":214,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5FO8"}]},{"type":"Beta strand","location":{"start":{"value":215,"modifier":"EXACT"},"end":{"value":218,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5FO8"}]},{"type":"Helix","location":{"start":{"value":219,"modifier":"EXACT"},"end":{"value":221,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3O8E"}]},{"type":"Beta strand","location":{"start":{"value":222,"modifier":"EXACT"},"end":{"value":224,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5FO8"}]},{"type":"Helix","location":{"start":{"value":229,"modifier":"EXACT"},"end":{"value":231,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5FO8"}]},{"type":"Beta strand","location":{"start":{"value":236,"modifier":"EXACT"},"end":{"value":240,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5FO8"}]},{"type":"Beta strand","location":{"start":{"value":251,"modifier":"EXACT"},"end":{"value":256,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5FO8"}]},{"type":"Beta strand","location":{"start":{"value":260,"modifier":"EXACT"},"end":{"value":264,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5FO8"}]},{"type":"Beta strand","location":{"start":{"value":266,"modifier":"EXACT"},"end":{"value":270,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5FO8"}]},{"type":"Beta strand","location":{"start":{"value":276,"modifier":"EXACT"},"end":{"value":278,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5FO8"}]},{"type":"Helix","location":{"start":{"value":279,"modifier":"EXACT"},"end":{"value":281,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5FO8"}]},{"type":"Beta strand","location":{"start":{"value":282,"modifier":"EXACT"},"end":{"value":285,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5FO8"}]},{"type":"Modified residue","location":{"start":{"value":384,"modifier":"EXACT"},"end":{"value":384,"modifier":"EXACT"},"sequence":"P15529-2"},"description":"Phosphotyrosine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10657632"}]},{"type":"Modified residue","location":{"start":{"value":369,"modifier":"EXACT"},"end":{"value":369,"modifier":"EXACT"},"sequence":"P15529-3"},"description":"Phosphotyrosine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10657632"}]},{"type":"Modified residue","location":{"start":{"value":354,"modifier":"EXACT"},"end":{"value":354,"modifier":"EXACT"},"sequence":"P15529-4"},"description":"Phosphotyrosine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10657632"}]},{"type":"Modified residue","location":{"start":{"value":370,"modifier":"EXACT"},"end":{"value":370,"modifier":"EXACT"},"sequence":"P15529-5"},"description":"Phosphotyrosine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10657632"}]},{"type":"Modified residue","location":{"start":{"value":355,"modifier":"EXACT"},"end":{"value":355,"modifier":"EXACT"},"sequence":"P15529-6"},"description":"Phosphotyrosine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10657632"}]},{"type":"Modified residue","location":{"start":{"value":340,"modifier":"EXACT"},"end":{"value":340,"modifier":"EXACT"},"sequence":"P15529-7"},"description":"Phosphotyrosine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10657632"}]},{"type":"Modified residue","location":{"start":{"value":321,"modifier":"EXACT"},"end":{"value":321,"modifier":"EXACT"},"sequence":"P15529-16"},"description":"Phosphotyrosine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10657632"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0180","category":"Biological process","name":"Complement pathway"},{"id":"KW-0968","category":"Cellular component","name":"Cytoplasmic vesicle"},{"id":"KW-0903","category":"Technical term","name":"Direct protein sequencing"},{"id":"KW-0225","category":"Disease","name":"Disease variant"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0278","category":"Biological process","name":"Fertilization"},{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-1068","category":"Disease","name":"Hemolytic uremic syndrome"},{"id":"KW-1183","category":"Molecular function","name":"Host cell receptor for virus entry"},{"id":"KW-0945","category":"Biological process","name":"Host-virus interaction"},{"id":"KW-0391","category":"Biological process","name":"Immunity"},{"id":"KW-0399","category":"Biological process","name":"Innate immunity"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0677","category":"Domain","name":"Repeat"},{"id":"KW-0732","category":"Domain","name":"Signal"},{"id":"KW-0768","category":"Domain","name":"Sushi"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"3260937","citationType":"journal article","authors":["Lublin D.M.","Liszewski M.K.","Post T.W.","Arce M.A.","le Beau M.M.","Rebentisch M.B.","Lemons R.S.","Seya T.","Atkinson J.P."],"citationCrossReferences":[{"database":"PubMed","id":"3260937"},{"database":"DOI","id":"10.1084/jem.168.1.181"}],"title":"Molecular cloning and chromosomal localization of human membrane cofactor protein (MCP). Evidence for inclusion in the multigene family of complement-regulatory proteins.","publicationDate":"1988","journal":"J. Exp. Med.","firstPage":"181","lastPage":"194","volume":"168"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM D)","PROTEIN SEQUENCE OF 35-58","INTERACTION WITH C3B"]},{"referenceNumber":2,"citation":{"id":"2050389","citationType":"journal article","authors":["Purcell D.F.","Russell S.M.","Deacon N.J.","Brown M.A.","Hooker D.J.","McKenzie I.F."],"citationCrossReferences":[{"database":"PubMed","id":"2050389"},{"database":"DOI","id":"10.1007/bf00216692"}],"title":"Alternatively spliced RNAs encode several isoforms of CD46 (MCP), a regulator of complement activation.","publicationDate":"1991","journal":"Immunogenetics","firstPage":"335","lastPage":"344","volume":"33"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM C)","ALTERNATIVE SPLICING"]},{"referenceNumber":3,"citation":{"id":"1711570","citationType":"journal article","authors":["Post T.W.","Liszewski M.K.","Adams E.M.","Tedja I.","Miller E.A.","Atkinson J.P."],"citationCrossReferences":[{"database":"PubMed","id":"1711570"},{"database":"DOI","id":"10.1084/jem.174.1.93"}],"title":"Membrane cofactor protein of the complement system: alternative splicing of serine/threonine/proline-rich exons and cytoplasmic tails produces multiple isoforms that correlate with protein phenotype.","publicationDate":"1991","journal":"J. Exp. Med.","firstPage":"93","lastPage":"102","volume":"174"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B; C; D; E AND F)"]},{"referenceNumber":4,"citation":{"id":"8418811","citationType":"journal article","authors":["Cervoni F.","Fenichel P.","Akhoundi C.","Hsi B.L.","Rossi B."],"citationCrossReferences":[{"database":"PubMed","id":"8418811"},{"database":"DOI","id":"10.1002/mrd.1080340117"}],"title":"Characterization of a cDNA clone coding for human testis membrane cofactor protein (MCP, CD46).","publicationDate":"1993","journal":"Mol. Reprod. Dev.","firstPage":"107","lastPage":"113","volume":"34"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM F)"],"referenceComments":[{"value":"Testis","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"9659228","citationType":"journal article","authors":["Hara T.","Suzuki Y.","Nakazawa T.","Nishimura H.","Nagasawa S.","Nishiguchi M.","Matsumoto M.","Hatanaka M.","Kitamura M.","Seya T."],"citationCrossReferences":[{"database":"PubMed","id":"9659228"},{"database":"DOI","id":"10.1046/j.1365-2567.1998.00455.x"}],"title":"Post-translational modification and intracellular localization of a splice product of CD46 cloned from human testis: role of the intracellular domains in O-glycosylation.","publicationDate":"1998","journal":"Immunology","firstPage":"546","lastPage":"555","volume":"93"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM N)"],"referenceComments":[{"value":"Testis","type":"TISSUE"}]},{"referenceNumber":6,"citation":{"id":"CI-BFA3UT90IL5G9","citationType":"submission","authors":["Xue Z.T.","Widegren B.","Salford L."],"title":"Molecular cloning of human CD46 (membrane cofactor protein) CDS from cancer cell lines in a retroviral vector system.","publicationDate":"OCT-2006","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS D; F AND L)"]},{"referenceNumber":7,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM D)"],"referenceComments":[{"value":"Teratocarcinoma","type":"TISSUE"}]},{"referenceNumber":8,"citation":{"id":"17974005","citationType":"journal article","authors":["Bechtel S.","Rosenfelder H.","Duda A.","Schmidt C.P.","Ernst U.","Wellenreuther R.","Mehrle A.","Schuster C.","Bahr A.","Bloecker H.","Heubner D.","Hoerlein A.","Michel G.","Wedler H.","Koehrer K.","Ottenwaelder B.","Poustka A.","Wiemann S.","Schupp I."],"citationCrossReferences":[{"database":"PubMed","id":"17974005"},{"database":"DOI","id":"10.1186/1471-2164-8-399"}],"title":"The full-ORF clone resource of the German cDNA consortium.","publicationDate":"2007","journal":"BMC Genomics","firstPage":"399","lastPage":"399","volume":"8"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS D AND E)"],"referenceComments":[{"value":"Fetal kidney","type":"TISSUE"},{"value":"Liver","type":"TISSUE"},{"value":"Salivary gland","type":"TISSUE"}]},{"referenceNumber":9,"citation":{"id":"CI-5AVBODINQ93DF","citationType":"submission","authors":["Suzuki Y.","Sugano S.","Totoki Y.","Toyoda A.","Takeda T.","Sakaki Y.","Tanaka A.","Yokoyama S."],"publicationDate":"APR-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B)","VARIANT PHE-13"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":10,"citation":{"id":"CI-DG518BA3CM3TQ","citationType":"submission","authoringGroup":["SeattleSNPs variation discovery resource"],"publicationDate":"FEB-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]","VARIANTS ASN-266; LEU-324; VAL-353 AND GLY-355"]},{"referenceNumber":11,"citation":{"id":"16710414","citationType":"journal article","authors":["Gregory S.G.","Barlow K.F.","McLay K.E.","Kaul R.","Swarbreck D.","Dunham A.","Scott C.E.","Howe K.L.","Woodfine K.","Spencer C.C.A.","Jones M.C.","Gillson C.","Searle S.","Zhou Y.","Kokocinski F.","McDonald L.","Evans R.","Phillips K.","Atkinson A.","Cooper R.","Jones C.","Hall R.E.","Andrews T.D.","Lloyd C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Anderson F.","Andrew R.W.","Ashwell R.I.S.","Aubin K.","Babbage A.K.","Bagguley C.L.","Bailey J.","Beasley H.","Bethel G.","Bird C.P.","Bray-Allen S.","Brown J.Y.","Brown A.J.","Buckley D.","Burton J.","Bye J.","Carder C.","Chapman J.C.","Clark S.Y.","Clarke G.","Clee C.","Cobley V.","Collier R.E.","Corby N.","Coville G.J.","Davies J.","Deadman R.","Dunn M.","Earthrowl M.","Ellington A.G.","Errington H.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Gay L.","Ghori M.R.J.","Gibson R.","Gilby L.M.","Gillett W.","Glithero R.J.","Grafham D.V.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Hammond S.","Harrison E.S.I.","Hart E.","Haugen E.","Heath P.D.","Holmes S.","Holt K.","Howden P.J.","Hunt A.R.","Hunt S.E.","Hunter G.","Isherwood J.","James R.","Johnson C.","Johnson D.","Joy A.","Kay M.","Kershaw J.K.","Kibukawa M.","Kimberley A.M.","King A.","Knights A.J.","Lad H.","Laird G.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Loveland J.","Lovell J.","Lush M.J.","Lyne R.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","Matthews N.S.W.","McLaren S.","Milne S.","Mistry S.","Moore M.J.F.","Nickerson T.","O'Dell C.N.","Oliver K.","Palmeiri A.","Palmer S.A.","Parker A.","Patel D.","Pearce A.V.","Peck A.I.","Pelan S.","Phelps K.","Phillimore B.J.","Plumb R.","Rajan J.","Raymond C.","Rouse G.","Saenphimmachak C.","Sehra H.K.","Sheridan E.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.","Steward C.","Subramanian S.","Sycamore N.","Tracey A.","Tromans A.","Van Helmond Z.","Wall M.","Wallis J.M.","White S.","Whitehead S.L.","Wilkinson J.E.","Willey D.L.","Williams H.","Wilming L.","Wray P.W.","Wu Z.","Coulson A.","Vaudin M.","Sulston J.E.","Durbin R.M.","Hubbard T.","Wooster R.","Dunham I.","Carter N.P.","McVean G.","Ross M.T.","Harrow J.","Olson M.V.","Beck S.","Rogers J.","Bentley D.R."],"citationCrossReferences":[{"database":"PubMed","id":"16710414"},{"database":"DOI","id":"10.1038/nature04727"}],"title":"The DNA sequence and biological annotation of human chromosome 1.","publicationDate":"2006","journal":"Nature","firstPage":"315","lastPage":"321","volume":"441"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":12,"citation":{"id":"CI-5GBD0VIIJ7C63","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"SEP-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":13,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM D)"],"referenceComments":[{"value":"Testis","type":"TISSUE"}]},{"referenceNumber":14,"citation":{"id":"10751138","citationType":"journal article","authors":["Kusuhara K.","Sasaki Y.","Nakao F.","Ihara K.","Hattori H.","Yamashita S.","Nihei K.","Koide N.","Aiba H.","Takeshita K.","Hara T."],"citationCrossReferences":[{"database":"PubMed","id":"10751138"},{"database":"DOI","id":"10.1086/315386"}],"title":"Analysis of measles virus binding sites of the CD46 gene in patients with subacute sclerosing panencephalitis.","publicationDate":"2000","journal":"J. Infect. Dis.","firstPage":"1447","lastPage":"1449","volume":"181"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF 1-158","VARIANTS PHE-13 AND GLN-59"]},{"referenceNumber":15,"citation":{"id":"7691939","citationType":"journal article","authors":["Cui W.","Hourcade D.","Post T.W.","Greenlund A.C.","Atkinson J.P.","Kumar V."],"citationCrossReferences":[{"database":"PubMed","id":"7691939"},{"database":"DOI","id":"10.4049/jimmunol.151.8.4137"}],"title":"Characterization of the promoter region of the membrane cofactor protein (CD46) gene of the human complement system and comparison to a membrane cofactor protein-like genetic element.","publicationDate":"1993","journal":"J. Immunol.","firstPage":"4137","lastPage":"4146","volume":"151"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-34"]},{"referenceNumber":16,"citation":{"id":"1479546","citationType":"journal article","authors":["Okabe M.","Ying X.","Nagira M.","Ikawa M.","Kohama Y.","Mimura T.","Tanaka K."],"citationCrossReferences":[{"database":"PubMed","id":"1479546"},{"database":"DOI","id":"10.1248/bpb1978.15.455"}],"title":"Homology of an acrosome-reacted sperm-specific antigen to CD46.","publicationDate":"1992","journal":"J. Pharmacobio-Dyn.","firstPage":"455","lastPage":"459","volume":"15"},"referencePositions":["PROTEIN SEQUENCE OF 35-60"],"referenceComments":[{"value":"Sperm","type":"TISSUE"}]},{"referenceNumber":17,"citation":{"id":"2298462","citationType":"journal article","authors":["Purcell D.F.","Deacon N.J.","Andrew S.M.","McKenzie I.F."],"citationCrossReferences":[{"database":"PubMed","id":"2298462"},{"database":"DOI","id":"10.1007/bf00702485"}],"title":"Human non-lineage antigen, CD46 (HuLy-m5): purification and partial sequencing demonstrates structural homology with complement-regulating glycoproteins.","publicationDate":"1990","journal":"Immunogenetics","firstPage":"21","lastPage":"28","volume":"31"},"referencePositions":["PROTEIN SEQUENCE OF 35-58"]},{"referenceNumber":18,"citation":{"id":"8371352","citationType":"journal article","authors":["Naniche D.","Varior-Krishnan G.","Cervoni F.","Wild T.F.","Rossi B.","Rabourdin-Combe C.","Gerlier D."],"citationCrossReferences":[{"database":"PubMed","id":"8371352"},{"database":"DOI","id":"10.1128/jvi.67.10.6025-6032.1993"}],"title":"Human membrane cofactor protein (CD46) acts as a cellular receptor for measles virus.","publicationDate":"1993","journal":"J. Virol.","firstPage":"6025","lastPage":"6032","volume":"67"},"referencePositions":["PROTEIN SEQUENCE OF 35-49","INTERACTION WITH MEASLES VIRUS (MICROBIAL INFECTION)"]},{"referenceNumber":19,"citation":{"id":"1717583","citationType":"journal article","authors":["Adams E.M.","Brown M.C.","Nunge M.","Krych M.","Atkinson J.P."],"citationCrossReferences":[{"database":"PubMed","id":"1717583"},{"database":"DOI","id":"10.4049/jimmunol.147.9.3005"}],"title":"Contribution of the repeating domains of membrane cofactor protein (CD46) of the complement system to ligand binding and cofactor activity.","publicationDate":"1991","journal":"J. Immunol.","firstPage":"3005","lastPage":"3011","volume":"147"},"referencePositions":["INTERACTION WITH C3B AND C4B"]},{"referenceNumber":20,"citation":{"id":"1601037","citationType":"journal article","authors":["Russell S.M.","Sparrow R.L.","McKenzie I.F.C.","Purcell D.F.J."],"citationCrossReferences":[{"database":"PubMed","id":"1601037"},{"database":"DOI","id":"10.1002/eji.1830220625"}],"title":"Tissue-specific and allelic expression of the complement regulator CD46 is controlled by alternative splicing.","publicationDate":"1992","journal":"Eur. J. Immunol.","firstPage":"1513","lastPage":"1518","volume":"22"},"referencePositions":["ALTERNATIVE SPLICING"]},{"referenceNumber":21,"citation":{"id":"8402913","citationType":"journal article","authors":["Doerig R.E.","Marcil A.","Chopra A.","Richardson C.D."],"citationCrossReferences":[{"database":"PubMed","id":"8402913"},{"database":"DOI","id":"10.1016/0092-8674(93)80071-l"}],"title":"The human CD46 molecule is a receptor for measles virus (Edmonston strain).","publicationDate":"1993","journal":"Cell","firstPage":"295","lastPage":"305","volume":"75"},"referencePositions":["INTERACTION WITH MEASLES VIRUS (MICROBIAL INFECTION)"]},{"referenceNumber":22,"citation":{"id":"7534417","citationType":"journal article","authors":["Manchester M.","Valsamakis A.","Kaufman R.","Liszewski M.K.","Alvarez J.","Atkinson J.P.","Lublin D.M.","Oldstone M.B."],"citationCrossReferences":[{"database":"PubMed","id":"7534417"},{"database":"DOI","id":"10.1073/pnas.92.6.2303"}],"title":"Measles virus and C3 binding sites are distinct on membrane cofactor protein (CD46).","publicationDate":"1995","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"2303","lastPage":"2307","volume":"92"},"referencePositions":["INTERACTION WITH MEASLES VIRUS (MICROBIAL INFECTION)"]},{"referenceNumber":23,"citation":{"id":"7708671","citationType":"journal article","authors":["Okada N.","Liszewski M.K.","Atkinson J.P.","Caparon M."],"citationCrossReferences":[{"database":"PubMed","id":"7708671"},{"database":"DOI","id":"10.1073/pnas.92.7.2489"}],"title":"Membrane cofactor protein (CD46) is a keratinocyte receptor for the M protein of the group A streptococcus.","publicationDate":"1995","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"2489","lastPage":"2493","volume":"92"},"referencePositions":["FUNCTION (MICROBIAL INFECTION)","INTERACTION WITH STREPTOCOCCUS PYOGENES M PROTEIN"]},{"referenceNumber":24,"citation":{"id":"7884872","citationType":"journal article","authors":["Schneider-Schaulies J.","Dunster L.M.","Schwartz-Albiez R.","Krohne G.","ter Meulen V."],"citationCrossReferences":[{"database":"PubMed","id":"7884872"},{"database":"DOI","id":"10.1128/jvi.69.4.2248-2256.1995"}],"title":"Physical association of moesin and CD46 as a receptor complex for measles virus.","publicationDate":"1995","journal":"J. Virol.","firstPage":"2248","lastPage":"2256","volume":"69"},"referencePositions":["INTERACTION WITH MSN"]},{"referenceNumber":25,"citation":{"id":"8764003","citationType":"journal article","authors":["Maisner A.","Alvarez J.","Liszewski M.K.","Atkinson D.J.","Atkinson J.P.","Herrler G."],"citationCrossReferences":[{"database":"PubMed","id":"8764003"},{"database":"DOI","id":"10.1128/jvi.70.8.4973-4977.1996"}],"title":"The N-glycan of the SCR 2 region is essential for membrane cofactor protein (CD46) to function as a measles virus receptor.","publicationDate":"1996","journal":"J. Virol.","firstPage":"4973","lastPage":"4977","volume":"70"},"referencePositions":["MUTAGENESIS OF ASN-83; ASN-114 AND ASN-273"]},{"referenceNumber":26,"citation":{"id":"9379894","citationType":"journal article","authors":["Kaellstroem H.","Liszewski M.K.","Atkinson J.P.","Jonsson A.-B."],"citationCrossReferences":[{"database":"PubMed","id":"9379894"},{"database":"DOI","id":"10.1046/j.1365-2958.1997.4841857.x"}],"title":"Membrane cofactor protein (MCP or CD46) is a cellular pilus receptor for pathogenic Neisseria.","publicationDate":"1997","journal":"Mol. Microbiol.","firstPage":"639","lastPage":"647","volume":"25"},"referencePositions":["FUNCTION (MICROBIAL INFECTION)","INTERACTION WITH NEISSERIA TYPE IV PILI"]},{"referenceNumber":27,"citation":{"id":"9759896","citationType":"journal article","authors":["Liszewski M.K.","Leung M.K.","Atkinson J.P."],"citationCrossReferences":[{"database":"PubMed","id":"9759896"},{"database":"DOI","id":"10.4049/jimmunol.161.7.3711"}],"title":"Membrane cofactor protein: importance of N- and O-glycosylation for complement regulatory function.","publicationDate":"1998","journal":"J. Immunol.","firstPage":"3711","lastPage":"3718","volume":"161"},"referencePositions":["MUTAGENESIS OF ASN-83; ASN-114 AND ASN-273"]},{"referenceNumber":28,"citation":{"id":"10619434","citationType":"journal article","authors":["Santoro F.","Kennedy P.E.","Locatelli G.","Malnati M.S.","Berger E.A.","Lusso P."],"citationCrossReferences":[{"database":"PubMed","id":"10619434"},{"database":"DOI","id":"10.1016/s0092-8674(00)81678-5"}],"title":"CD46 is a cellular receptor for human herpesvirus 6.","publicationDate":"1999","journal":"Cell","firstPage":"817","lastPage":"827","volume":"99"},"referencePositions":["BINDING OF HUMAN HERPESVIRUS 6"]},{"referenceNumber":29,"citation":{"id":"10657632","citationType":"journal article","authors":["Wang G.","Liszewski M.K.","Chan A.C.","Atkinson J.P."],"citationCrossReferences":[{"database":"PubMed","id":"10657632"},{"database":"DOI","id":"10.4049/jimmunol.164.4.1839"}],"title":"Membrane cofactor protein (MCP; CD46): isoform-specific tyrosine phosphorylation.","publicationDate":"2000","journal":"J. Immunol.","firstPage":"1839","lastPage":"1846","volume":"164"},"referencePositions":["PHOSPHORYLATION AT TYR-384 (ISOFORM B)","PHOSPHORYLATION AT TYR-369 (ISOFORM D)","PHOSPHORYLATION AT TYR-354 (ISOFORM F)","PHOSPHORYLATION AT TYR-370 (ISOFORM H)","PHOSPHORYLATION AT TYR-355 (ISOFORM J)","PHOSPHORYLATION AT TYR-340 (ISOFORM L)","PHOSPHORYLATION AT TYR-321 (ISOFORM 3)"]},{"referenceNumber":30,"citation":{"id":"10843656","citationType":"journal article","authors":["Astier A.","Trescol-Biemont M.-C.","Azocar O.","Lamouille B.","Rabourdin-Combe C."],"citationCrossReferences":[{"database":"PubMed","id":"10843656"},{"database":"DOI","id":"10.4049/jimmunol.164.12.6091"}],"title":"CD46, a new costimulatory molecule for T cells, that induces p120CBL and LAT phosphorylation.","publicationDate":"2000","journal":"J. Immunol.","firstPage":"6091","lastPage":"6095","volume":"164"},"referencePositions":["FUNCTION"]},{"referenceNumber":31,"citation":{"id":"10972291","citationType":"journal article","authors":["Tatsuo H.","Ono N.","Tanaka K.","Yanagi Y."],"citationCrossReferences":[{"database":"PubMed","id":"10972291"},{"database":"DOI","id":"10.1038/35022579"}],"title":"SLAM (CDw150) is a cellular receptor for measles virus.","publicationDate":"2000","journal":"Nature","firstPage":"893","lastPage":"897","volume":"406"},"referencePositions":["FUNCTION (MICROBIAL INFECTION)","INTERACTION WITH MEASLES VIRUS HEMAGGLUTININ PROTEIN (MICROBIAL INFECTION)"]},{"referenceNumber":32,"citation":{"id":"11260136","citationType":"journal article","authors":["Kaellstroem H.","Blackmer Gill D.","Albiger B.","Liszewski M.K.","Atkinson J.P.","Jonsson A.-B."],"citationCrossReferences":[{"database":"PubMed","id":"11260136"},{"database":"DOI","id":"10.1046/j.1462-5822.2001.00095.x"}],"title":"Attachment of Neisseria gonorrhoeae to the cellular pilus receptor CD46: identification of domains important for bacterial adherence.","publicationDate":"2001","journal":"Cell. Microbiol.","firstPage":"133","lastPage":"143","volume":"3"},"referencePositions":["FUNCTION (MICROBIAL INFECTION)","INTERACTION WITH NEISSERIA TYPE IV PILI","MUTAGENESIS OF ASN-83; ASN-114 AND ASN-273"]},{"referenceNumber":33,"citation":{"id":"12171934","citationType":"journal article","authors":["Greenstone H.L.","Santoro F.","Lusso P.","Berger E.A."],"citationCrossReferences":[{"database":"PubMed","id":"12171934"},{"database":"DOI","id":"10.1074/jbc.m206488200"}],"title":"Human Herpesvirus 6 and Measles Virus employ distinct CD46 domains for receptor function.","publicationDate":"2002","journal":"J. Biol. Chem.","firstPage":"39112","lastPage":"39118","volume":"277"},"referencePositions":["BINDING OF HUMAN HERPESVIRUS 6"]},{"referenceNumber":34,"citation":{"id":"11901164","citationType":"journal article","authors":["Lee S.W.","Bonnah R.A.","Higashi D.L.","Atkinson J.P.","Milgram S.L.","So M."],"citationCrossReferences":[{"database":"PubMed","id":"11901164"},{"database":"DOI","id":"10.1083/jcb.200109005"}],"title":"CD46 is phosphorylated at tyrosine 354 upon infection of epithelial cells by Neisseria gonorrhoeae.","publicationDate":"2002","journal":"J. Cell Biol.","firstPage":"951","lastPage":"957","volume":"156"},"referencePositions":["PHOSPHORYLATION (ISOFORMS B/D/F/H/J/L/3)"]},{"referenceNumber":35,"citation":{"id":"11971006","citationType":"journal article","authors":["Giannakis E.","Jokiranta T.S.","Ormsby R.J.","Duthy T.G.","Male D.A.","Christiansen D.","Fischetti V.A.","Bagley C.","Loveland B.E.","Gordon D.L."],"citationCrossReferences":[{"database":"PubMed","id":"11971006"},{"database":"DOI","id":"10.4049/jimmunol.168.9.4585"}],"title":"Identification of the streptococcal M protein binding site on membrane cofactor protein (CD46).","publicationDate":"2002","journal":"J. Immunol.","firstPage":"4585","lastPage":"4592","volume":"168"},"referencePositions":["FUNCTION (MICROBIAL INFECTION)","INTERACTION WITH STREPTOCOCCUS PYOGENES M PROTEIN"]},{"referenceNumber":36,"citation":{"id":"12112588","citationType":"journal article","authors":["Riley R.C.","Kemper C.","Leung M.","Atkinson J.P."],"citationCrossReferences":[{"database":"PubMed","id":"12112588"},{"database":"DOI","id":"10.1002/mrd.10144"}],"title":"Characterization of human membrane cofactor protein (MCP; CD46) on spermatozoa.","publicationDate":"2002","journal":"Mol. Reprod. Dev.","firstPage":"534","lastPage":"546","volume":"62"},"referencePositions":["SUBCELLULAR LOCATION","GLYCOSYLATION"]},{"referenceNumber":37,"citation":{"id":"12724329","citationType":"journal article","authors":["Santoro F.","Greenstone H.L.","Insinga A.","Liszewski M.K.","Atkinson J.P.","Lusso P.","Berger E.A."],"citationCrossReferences":[{"database":"PubMed","id":"12724329"},{"database":"DOI","id":"10.1074/jbc.m302373200"}],"title":"Interaction of glycoprotein H of human herpesvirus 6 with the cellular receptor CD46.","publicationDate":"2003","journal":"J. Biol. Chem.","firstPage":"25964","lastPage":"25969","volume":"278"},"referencePositions":["FUNCTION (MICROBIAL INFECTION)","INTERACTION WITH HUMAN HERPESVIRUS 6 GH PROTEIN"]},{"referenceNumber":38,"citation":{"id":"14597734","citationType":"journal article","authors":["Gill D.B.","Koomey M.","Cannon J.G.","Atkinson J.P."],"citationCrossReferences":[{"database":"PubMed","id":"14597734"},{"database":"DOI","id":"10.1084/jem.20031159"}],"title":"Down-regulation of CD46 by piliated Neisseria gonorrhoeae.","publicationDate":"2003","journal":"J. Exp. Med.","firstPage":"1313","lastPage":"1322","volume":"198"},"referencePositions":["SUBCELLULAR LOCATION"]},{"referenceNumber":39,"citation":{"id":"12663806","citationType":"journal article","authors":["Mori Y.","Yang X.","Akkapaiboon P.","Okuno T.","Yamanishi K."],"citationCrossReferences":[{"database":"PubMed","id":"12663806"},{"database":"DOI","id":"10.1128/jvi.77.8.4992-4999.2003"}],"title":"Human herpesvirus 6 variant A glycoprotein H-glycoprotein L-glycoprotein Q complex associates with human CD46.","publicationDate":"2003","journal":"J. Virol.","firstPage":"4992","lastPage":"4999","volume":"77"},"referencePositions":["FUNCTION (MICROBIAL INFECTION)","INTERACTION WITH HUMAN HERPESVIRUS 6 GH PROTEIN"]},{"referenceNumber":40,"citation":{"id":"12915534","citationType":"journal article","authors":["Segerman A.","Atkinson J.P.","Marttila M.","Dennerquist V.","Wadell G.","Arnberg N."],"citationCrossReferences":[{"database":"PubMed","id":"12915534"},{"database":"DOI","id":"10.1128/jvi.77.17.9183-9191.2003"}],"title":"Adenovirus type 11 uses CD46 as a cellular receptor.","publicationDate":"2003","journal":"J. Virol.","firstPage":"9183","lastPage":"9191","volume":"77"},"referencePositions":["FUNCTION (MICROBIAL INFECTION)","INTERACTION WITH HUMAN ADENOVIRUS B FIBER PROTEIN"]},{"referenceNumber":41,"citation":{"id":"14615110","citationType":"journal article","authors":["Noris M.","Brioschi S.","Caprioli J.","Todeschini M.","Bresin E.","Porrati F.","Gamba S.","Remuzzi G."],"citationCrossReferences":[{"database":"PubMed","id":"14615110"},{"database":"DOI","id":"10.1016/s0140-6736(03)14742-3"}],"title":"Familial haemolytic uraemic syndrome and an MCP mutation.","publicationDate":"2003","journal":"Lancet","firstPage":"1542","lastPage":"1547","volume":"362"},"referencePositions":["DISEASE"]},{"referenceNumber":42,"citation":{"id":"12540904","citationType":"journal article","authors":["Kemper C.","Chan A.C.","Green J.M.","Brett K.A.","Murphy K.M.","Atkinson J.P."],"citationCrossReferences":[{"database":"PubMed","id":"12540904"},{"database":"DOI","id":"10.1038/nature01315"}],"title":"Activation of human CD4+ cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype.","publicationDate":"2003","journal":"Nature","firstPage":"388","lastPage":"392","volume":"421"},"referencePositions":["FUNCTION"]},{"referenceNumber":43,"citation":{"id":"14566335","citationType":"journal article","authors":["Gaggar A.","Shayakhmetov D.M.","Lieber A."],"citationCrossReferences":[{"database":"PubMed","id":"14566335"},{"database":"DOI","id":"10.1038/nm952"}],"title":"CD46 is a cellular receptor for group B adenoviruses.","publicationDate":"2003","journal":"Nat. Med.","firstPage":"1408","lastPage":"1412","volume":"9"},"referencePositions":["FUNCTION (MICROBIAL INFECTION)","INTERACTION WITH HUMAN ADENOVIRUS B FIBER PROTEIN","IDENTIFICATION BY MASS SPECTROMETRY"]},{"referenceNumber":44,"citation":{"id":"15307194","citationType":"journal article","authors":["Hakulinen J.","Junnikkala S.","Sorsa T.","Meri S."],"citationCrossReferences":[{"database":"PubMed","id":"15307194"},{"database":"DOI","id":"10.1002/eji.200424969"}],"title":"Complement inhibitor membrane cofactor protein (MCP; CD46) is constitutively shed from cancer cell membranes in vesicles and converted by a metalloproteinase to a functionally active soluble form.","publicationDate":"2004","journal":"Eur. J. Immunol.","firstPage":"2620","lastPage":"2629","volume":"34"},"referencePositions":["GLYCOSYLATION","SUBCELLULAR LOCATION"]},{"referenceNumber":45,"citation":{"id":"15047806","citationType":"journal article","authors":["Wu E.","Trauger S.A.","Pache L.","Mullen T.-M.","von Seggern D.J.","Siuzdak G.","Nemerow G.R."],"citationCrossReferences":[{"database":"PubMed","id":"15047806"},{"database":"DOI","id":"10.1128/jvi.78.8.3897-3905.2004"}],"title":"Membrane cofactor protein is a receptor for adenoviruses associated with epidemic keratoconjunctivitis.","publicationDate":"2004","journal":"J. Virol.","firstPage":"3897","lastPage":"3905","volume":"78"},"referencePositions":["FUNCTION (MICROBIAL INFECTION)","INTERACTION WITH HUMAN ADENOVIRUS D TYPE 37 PIV/FIBER PROTEIN","IDENTIFICATION BY MASS SPECTROMETRY"]},{"referenceNumber":46,"citation":{"id":"15078926","citationType":"journal article","authors":["Sirena D.","Lilienfeld B.","Eisenhut M.","Kaelin S.","Boucke K.","Beerli R.R.","Vogt L.","Ruedl C.","Bachmann M.F.","Greber U.F.","Hemmi S."],"citationCrossReferences":[{"database":"PubMed","id":"15078926"},{"database":"DOI","id":"10.1128/jvi.78.9.4454-4462.2004"}],"title":"The human membrane cofactor CD46 is a receptor for species B adenovirus serotype 3.","publicationDate":"2004","journal":"J. Virol.","firstPage":"4454","lastPage":"4462","volume":"78"},"referencePositions":["FUNCTION (MICROBIAL INFECTION)","INTERACTION WITH HUMAN ADENOVIRUS B TYPE 3 FIBER PROTEIN"]},{"referenceNumber":47,"citation":{"id":"15919905","citationType":"journal article","authors":["Gaggar A.","Shayakhmetov D.M.","Liszewski M.K.","Atkinson J.P.","Lieber A."],"citationCrossReferences":[{"database":"PubMed","id":"15919905"},{"database":"DOI","id":"10.1128/jvi.79.12.7503-7513.2005"}],"title":"Localization of regions in CD46 that interact with adenovirus.","publicationDate":"2005","journal":"J. Virol.","firstPage":"7503","lastPage":"7513","volume":"79"},"referencePositions":["FUNCTION (MICROBIAL INFECTION)","INTERACTION WITH HUMAN ADENOVIRUS B TYPE 35 FIBER PROTEIN"]},{"referenceNumber":48,"citation":{"id":"16254377","citationType":"journal article","authors":["Marttila M.","Persson D.","Gustafsson D.","Liszewski M.K.","Atkinson J.P.","Wadell G.","Arnberg N."],"citationCrossReferences":[{"database":"PubMed","id":"16254377"},{"database":"DOI","id":"10.1128/jvi.79.22.14429-14436.2005"}],"title":"CD46 is a cellular receptor for all species B adenoviruses except types 3 and 7.","publicationDate":"2005","journal":"J. Virol.","firstPage":"14429","lastPage":"14436","volume":"79"},"referencePositions":["FUNCTION (MICROBIAL INFECTION)","INTERACTION WITH HUMAN ADENOVIRUS B FIBER PROTEIN"]},{"referenceNumber":49,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":50,"citation":{"id":"32581096","citationType":"journal article","authors":["Feng Y.","Yi C.","Liu X.","Qu L.","Su W.","Shu T.","Zheng X.","Ye X.","Luo J.","Hao M.","Sun X.","Li L.","Liu X.","Yang C.","Guan S.","Chen L.","Feng L."],"citationCrossReferences":[{"database":"PubMed","id":"32581096"},{"database":"DOI","id":"10.1128/jvi.00747-20"}],"title":"Human Desmoglein-2 and Human CD46 Mediate Human Adenovirus Type 55 Infection, but Human Desmoglein-2 Plays the Major Roles.","publicationDate":"2020","journal":"J. Virol.","firstPage":"0","lastPage":"0","volume":"94"},"referencePositions":["FUNCTION (MICROBIAL INFECTION)","INTERACTION WITH HUMAN ADENOVIRUS 55 FIBER PROTEIN"]},{"referenceNumber":51,"citation":{"id":"10357804","citationType":"journal article","authors":["Casasnovas J.M.","Larvie M.","Stehle T."],"citationCrossReferences":[{"database":"PubMed","id":"10357804"},{"database":"DOI","id":"10.1093/emboj/18.11.2911"}],"title":"Crystal structure of two CD46 domains reveals an extended measles virus-binding surface.","publicationDate":"1999","journal":"EMBO J.","firstPage":"2911","lastPage":"2922","volume":"18"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF 35-160"]},{"referenceNumber":52,"citation":{"id":"14566051","citationType":"journal article","authors":["Richards A.","Kemp E.J.","Liszewski M.K.","Goodship J.A.","Lampe A.K.","Decorte R.","Muesluemanoglu M.H.","Kavukcu S.","Filler G.","Pirson Y.","Wen L.S.","Atkinson J.P.","Goodship T.H.J."],"citationCrossReferences":[{"database":"PubMed","id":"14566051"},{"database":"DOI","id":"10.1073/pnas.2135497100"}],"title":"Mutations in human complement regulator, membrane cofactor protein (CD46), predispose to development of familial hemolytic uremic syndrome.","publicationDate":"2003","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"12966","lastPage":"12971","volume":"100"},"referencePositions":["CHARACTERIZATION OF VARIANTS AHUS2 PRO-240 AND 271-ASP-SER-272 DEL"]},{"referenceNumber":53,"citation":{"id":"20010840","citationType":"journal article","authors":["Santiago C.","Celma M.L.","Stehle T.","Casasnovas J.M."],"citationCrossReferences":[{"database":"PubMed","id":"20010840"},{"database":"DOI","id":"10.1038/nsmb.1726"}],"title":"Structure of the measles virus hemagglutinin bound to the CD46 receptor.","publicationDate":"2010","journal":"Nat. Struct. Mol. Biol.","firstPage":"124","lastPage":"129","volume":"17"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (3.10 ANGSTROMS) OF 35-160","GLYCOSYLATION AT ASN-114","FUNCTION (MICROBIAL INFECTION)"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"3INB"}]},{"referenceNumber":54,"citation":{"id":"16621965","citationType":"journal article","authoringGroup":["The international registry of recurrent and familial HUS/TTP"],"authors":["Caprioli J.","Noris M.","Brioschi S.","Pianetti G.","Castelletti F.","Bettinaglio P.","Mele C.","Bresin E.","Cassis L.","Gamba S.","Porrati F.","Bucchioni S.","Monteferrante G.","Fang C.J.","Liszewski M.K.","Kavanagh D.","Atkinson J.P.","Remuzzi G."],"citationCrossReferences":[{"database":"PubMed","id":"16621965"},{"database":"DOI","id":"10.1182/blood-2005-10-007252"}],"title":"Genetics of HUS: the impact of MCP, CFH, and IF mutations on clinical presentation, response to treatment, and outcome.","publicationDate":"2006","journal":"Blood","firstPage":"1267","lastPage":"1279","volume":"108"},"referencePositions":["VARIANT AHUS2 TYR-35"]},{"referenceNumber":55,"citation":{"id":"16386793","citationType":"journal article","authors":["Esparza-Gordillo J.","Jorge E.G.","Garrido C.A.","Carreras L.","Lopez-Trascasa M.","Sanchez-Corral P.","de Cordoba S.R."],"citationCrossReferences":[{"database":"PubMed","id":"16386793"},{"database":"DOI","id":"10.1016/j.molimm.2005.11.008"}],"title":"Insights into hemolytic uremic syndrome: segregation of three independent predisposition factors in a large, multiple affected pedigree.","publicationDate":"2006","journal":"Mol. Immunol.","firstPage":"1769","lastPage":"1775","volume":"43"},"referencePositions":["VARIANT AHUS2 SER-165"]},{"referenceNumber":56,"citation":{"id":"16959974","citationType":"journal article","authors":["Sjoeblom T.","Jones S.","Wood L.D.","Parsons D.W.","Lin J.","Barber T.D.","Mandelker D.","Leary R.J.","Ptak J.","Silliman N.","Szabo S.","Buckhaults P.","Farrell C.","Meeh P.","Markowitz S.D.","Willis J.","Dawson D.","Willson J.K.V.","Gazdar A.F.","Hartigan J.","Wu L.","Liu C.","Parmigiani G.","Park B.H.","Bachman K.E.","Papadopoulos N.","Vogelstein B.","Kinzler K.W.","Velculescu V.E."],"citationCrossReferences":[{"database":"PubMed","id":"16959974"},{"database":"DOI","id":"10.1126/science.1133427"}],"title":"The consensus coding sequences of human breast and colorectal cancers.","publicationDate":"2006","journal":"Science","firstPage":"268","lastPage":"274","volume":"314"},"referencePositions":["VARIANTS [LARGE SCALE ANALYSIS] TYR-228 AND VAL-353"]},{"referenceNumber":57,"citation":{"id":"20513133","citationType":"journal article","authors":["Maga T.K.","Nishimura C.J.","Weaver A.E.","Frees K.L.","Smith R.J.H."],"citationCrossReferences":[{"database":"PubMed","id":"20513133"},{"database":"DOI","id":"10.1002/humu.21256"}],"title":"Mutations in alternative pathway complement proteins in American patients with atypical hemolytic uremic syndrome.","publicationDate":"2010","journal":"Hum. Mutat.","firstPage":"E1445","lastPage":"E1460","volume":"31"},"referencePositions":["VARIANTS AHUS2 CYS-216 AND ARG-231"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"Y00651","properties":[{"key":"ProteinId","value":"CAA68675.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"M58050","properties":[{"key":"ProteinId","value":"AAA62833.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"X59405","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"X59406","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"X59407","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"X59408","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"X59409","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"X59410","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"S51940","properties":[{"key":"ProteinId","value":"AAB24802.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"D84105","properties":[{"key":"ProteinId","value":"BAA12224.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"EF076055","properties":[{"key":"ProteinId","value":"ABK81635.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"EF076056","properties":[{"key":"ProteinId","value":"ABK81636.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"EF076057","properties":[{"key":"ProteinId","value":"ABK81637.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"EF076058","properties":[{"key":"ProteinId","value":"ABK81638.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK291227","properties":[{"key":"ProteinId","value":"BAF83916.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BX537451","properties":[{"key":"ProteinId","value":"CAD97694.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BX640613","properties":[{"key":"ProteinId","value":"CAE45719.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BX649050","properties":[{"key":"ProteinId","value":"CAI45983.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK222822","properties":[{"key":"ProteinId","value":"BAD96542.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AY916779","properties":[{"key":"ProteinId","value":"AAW82433.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL035209","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL365178","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471100","properties":[{"key":"ProteinId","value":"EAW93465.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471100","properties":[{"key":"ProteinId","value":"EAW93470.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471100","properties":[{"key":"ProteinId","value":"EAW93476.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC030594","properties":[{"key":"ProteinId","value":"AAH30594.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF209712","properties":[{"key":"ProteinId","value":"AAF73844.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF209713","properties":[{"key":"ProteinId","value":"AAF73845.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF209714","properties":[{"key":"ProteinId","value":"AAF73846.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"S65879","properties":[{"key":"ProteinId","value":"AAD13968.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"CCDS","id":"CCDS1479.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P15529-9"},{"database":"CCDS","id":"CCDS1480.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P15529-3"},{"database":"CCDS","id":"CCDS1481.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P15529-4"},{"database":"CCDS","id":"CCDS1482.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P15529-2"},{"database":"CCDS","id":"CCDS1484.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P15529-7"},{"database":"CCDS","id":"CCDS1485.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P15529-1"},{"database":"CCDS","id":"CCDS31008.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P15529-11"},{"database":"CCDS","id":"CCDS31009.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P15529-12"},{"database":"CCDS","id":"CCDS86048.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P15529-6"},{"database":"PIR","id":"G02913","properties":[{"key":"EntryName","value":"G02913"}]},{"database":"PIR","id":"I54479","properties":[{"key":"EntryName","value":"I54479"}]},{"database":"PIR","id":"I57998","properties":[{"key":"EntryName","value":"I57998"}]},{"database":"PIR","id":"S01896","properties":[{"key":"EntryName","value":"S01896"}]},{"database":"RefSeq","id":"NP_002380.3","properties":[{"key":"NucleotideSequenceId","value":"NM_002389.4"}],"isoformId":"P15529-1"},{"database":"RefSeq","id":"NP_722548.1","properties":[{"key":"NucleotideSequenceId","value":"NM_153826.4"}],"isoformId":"P15529-3"},{"database":"RefSeq","id":"NP_758860.1","properties":[{"key":"NucleotideSequenceId","value":"NM_172350.3"}],"isoformId":"P15529-9"},{"database":"RefSeq","id":"NP_758861.1","properties":[{"key":"NucleotideSequenceId","value":"NM_172351.3"}],"isoformId":"P15529-11"},{"database":"RefSeq","id":"NP_758862.1","properties":[{"key":"NucleotideSequenceId","value":"NM_172352.3"}],"isoformId":"P15529-12"},{"database":"RefSeq","id":"NP_758863.1","properties":[{"key":"NucleotideSequenceId","value":"NM_172353.3"}],"isoformId":"P15529-4"},{"database":"RefSeq","id":"NP_758865.1","properties":[{"key":"NucleotideSequenceId","value":"NM_172355.3"}],"isoformId":"P15529-14"},{"database":"RefSeq","id":"NP_758866.1","properties":[{"key":"NucleotideSequenceId","value":"NM_172356.3"}],"isoformId":"P15529-6"},{"database":"RefSeq","id":"NP_758867.1","properties":[{"key":"NucleotideSequenceId","value":"NM_172357.3"}],"isoformId":"P15529-15"},{"database":"RefSeq","id":"NP_758869.1","properties":[{"key":"NucleotideSequenceId","value":"NM_172359.3"}],"isoformId":"P15529-2"},{"database":"RefSeq","id":"NP_758871.1","properties":[{"key":"NucleotideSequenceId","value":"NM_172361.3"}],"isoformId":"P15529-7"},{"database":"RefSeq","id":"XP_011507865.1","properties":[{"key":"NucleotideSequenceId","value":"XM_011509563.3"}],"isoformId":"P15529-5"},{"database":"RefSeq","id":"XP_047276844.1","properties":[{"key":"NucleotideSequenceId","value":"XM_047420888.1"}],"isoformId":"P15529-1"},{"database":"RefSeq","id":"XP_047276850.1","properties":[{"key":"NucleotideSequenceId","value":"XM_047420894.1"}],"isoformId":"P15529-11"},{"database":"RefSeq","id":"XP_047276857.1","properties":[{"key":"NucleotideSequenceId","value":"XM_047420901.1"}],"isoformId":"P15529-14"},{"database":"RefSeq","id":"XP_047276865.1","properties":[{"key":"NucleotideSequenceId","value":"XM_047420909.1"}],"isoformId":"P15529-12"},{"database":"RefSeq","id":"XP_054192620.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054336645.1"}],"isoformId":"P15529-1"},{"database":"RefSeq","id":"XP_054192621.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054336646.1"}],"isoformId":"P15529-5"},{"database":"RefSeq","id":"XP_054192622.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054336647.1"}],"isoformId":"P15529-11"},{"database":"RefSeq","id":"XP_054192623.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054336648.1"}],"isoformId":"P15529-14"},{"database":"RefSeq","id":"XP_054192624.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054336649.1"}],"isoformId":"P15529-12"},{"database":"PDB","id":"1CKL","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.10 A"},{"key":"Chains","value":"A/B/C/D/E/F=35-160"}]},{"database":"PDB","id":"2O39","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.85 A"},{"key":"Chains","value":"C/D=35-160"}]},{"database":"PDB","id":"3INB","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.10 A"},{"key":"Chains","value":"C/D=35-160"}]},{"database":"PDB","id":"3L89","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.50 A"},{"key":"Chains","value":"M/N/O/P/Q/R/S/T/U/V/W/X=35-160"}]},{"database":"PDB","id":"3O8E","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.84 A"},{"key":"Chains","value":"B/D=35-286"}]},{"database":"PDB","id":"5FO8","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.40 A"},{"key":"Chains","value":"C=35-286"}]},{"database":"PDB","id":"8QK3","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.20 A"},{"key":"Chains","value":"E=1-392"}]},{"database":"PDBsum","id":"1CKL","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2O39","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3INB","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3L89","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3O8E","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5FO8","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8QK3","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"P15529","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-18455","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P15529","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"110346","properties":[{"key":"Interactions","value":"49"}]},{"database":"DIP","id":"DIP-41232N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P15529","properties":[{"key":"Number of interactors","value":"194"}]},{"database":"IntAct","id":"P15529","properties":[{"key":"Interactions","value":"106"}]},{"database":"MINT","id":"P15529","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-CD46","properties":[{"key":"Evidences","value":"2 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000313875","properties":[{"key":"Description","value":"-"}]},{"database":"GlyConnect","id":"P15529","properties":[{"key":"glycosylation","value":"8 N-Linked glycans (2 sites)"}]},{"database":"GlyCosmos","id":"P15529","properties":[{"key":"glycosylation","value":"21 sites, 7 glycans"}]},{"database":"GlyGen","id":"P15529","properties":[{"key":"glycosylation","value":"22 sites, 58 N-linked glycans (3 sites), 2 O-linked glycans (2 sites)"}]},{"database":"iPTMnet","id":"P15529","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"P15529","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"P15529","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"CD46","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"41019474","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"P15529","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"P15529","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000313875","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P15529","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"53167","properties":[{"key":"Description","value":"-"}],"isoformId":"P15529-1"},{"database":"ProteomicsDB","id":"53168","properties":[{"key":"Description","value":"-"}],"isoformId":"P15529-10"},{"database":"ProteomicsDB","id":"53169","properties":[{"key":"Description","value":"-"}],"isoformId":"P15529-11"},{"database":"ProteomicsDB","id":"53170","properties":[{"key":"Description","value":"-"}],"isoformId":"P15529-12"},{"database":"ProteomicsDB","id":"53171","properties":[{"key":"Description","value":"-"}],"isoformId":"P15529-13"},{"database":"ProteomicsDB","id":"53172","properties":[{"key":"Description","value":"-"}],"isoformId":"P15529-14"},{"database":"ProteomicsDB","id":"53173","properties":[{"key":"Description","value":"-"}],"isoformId":"P15529-15"},{"database":"ProteomicsDB","id":"53174","properties":[{"key":"Description","value":"-"}],"isoformId":"P15529-16"},{"database":"ProteomicsDB","id":"53175","properties":[{"key":"Description","value":"-"}],"isoformId":"P15529-2"},{"database":"ProteomicsDB","id":"53176","properties":[{"key":"Description","value":"-"}],"isoformId":"P15529-3"},{"database":"ProteomicsDB","id":"53177","properties":[{"key":"Description","value":"-"}],"isoformId":"P15529-4"},{"database":"ProteomicsDB","id":"53178","properties":[{"key":"Description","value":"-"}],"isoformId":"P15529-5"},{"database":"ProteomicsDB","id":"53179","properties":[{"key":"Description","value":"-"}],"isoformId":"P15529-6"},{"database":"ProteomicsDB","id":"53180","properties":[{"key":"Description","value":"-"}],"isoformId":"P15529-7"},{"database":"ProteomicsDB","id":"53181","properties":[{"key":"Description","value":"-"}],"isoformId":"P15529-8"},{"database":"ProteomicsDB","id":"53182","properties":[{"key":"Description","value":"-"}],"isoformId":"P15529-9"},{"database":"Pumba","id":"P15529","properties":[{"key":"Description","value":"-"}]},{"database":"TopDownProteomics","id":"P15529-4","properties":[{"key":"Description","value":"-"}],"isoformId":"P15529-4"},{"database":"ABCD","id":"P15529","properties":[{"key":"antibodies","value":"10 sequenced antibodies"}]},{"database":"Antibodypedia","id":"2378","properties":[{"key":"antibodies","value":"1332 antibodies from 48 providers"}]},{"database":"DNASU","id":"4179","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000322875.8","properties":[{"key":"ProteinId","value":"ENSP00000313875.4"},{"key":"GeneId","value":"ENSG00000117335.22"}],"isoformId":"P15529-2"},{"database":"Ensembl","id":"ENST00000322918.9","properties":[{"key":"ProteinId","value":"ENSP00000314664.5"},{"key":"GeneId","value":"ENSG00000117335.22"}],"isoformId":"P15529-9"},{"database":"Ensembl","id":"ENST00000354848.5","properties":[{"key":"ProteinId","value":"ENSP00000346912.1"},{"key":"GeneId","value":"ENSG00000117335.22"}],"isoformId":"P15529-3"},{"database":"Ensembl","id":"ENST00000357714.5","properties":[{"key":"ProteinId","value":"ENSP00000350346.1"},{"key":"GeneId","value":"ENSG00000117335.22"}],"isoformId":"P15529-4"},{"database":"Ensembl","id":"ENST00000358170.6","properties":[{"key":"ProteinId","value":"ENSP00000350893.2"},{"key":"GeneId","value":"ENSG00000117335.22"}],"isoformId":"P15529-1"},{"database":"Ensembl","id":"ENST00000360212.6","properties":[{"key":"ProteinId","value":"ENSP00000353342.2"},{"key":"GeneId","value":"ENSG00000117335.22"}],"isoformId":"P15529-7"},{"database":"Ensembl","id":"ENST00000367041.5","properties":[{"key":"ProteinId","value":"ENSP00000356008.1"},{"key":"GeneId","value":"ENSG00000117335.22"}],"isoformId":"P15529-12"},{"database":"Ensembl","id":"ENST00000367042.6","properties":[{"key":"ProteinId","value":"ENSP00000356009.1"},{"key":"GeneId","value":"ENSG00000117335.22"}],"isoformId":"P15529-11"},{"database":"Ensembl","id":"ENST00000367047.5","properties":[{"key":"ProteinId","value":"ENSP00000356014.1"},{"key":"GeneId","value":"ENSG00000117335.22"}],"isoformId":"P15529-16"},{"database":"Ensembl","id":"ENST00000480003.5","properties":[{"key":"ProteinId","value":"ENSP00000418471.1"},{"key":"GeneId","value":"ENSG00000117335.22"}],"isoformId":"P15529-6"},{"database":"Ensembl","id":"ENST00000887052.1","properties":[{"key":"ProteinId","value":"ENSP00000557111.1"},{"key":"GeneId","value":"ENSG00000117335.22"}],"isoformId":"P15529-11"},{"database":"Ensembl","id":"ENST00000887053.1","properties":[{"key":"ProteinId","value":"ENSP00000557112.1"},{"key":"GeneId","value":"ENSG00000117335.22"}],"isoformId":"P15529-15"},{"database":"Ensembl","id":"ENST00000887054.1","properties":[{"key":"ProteinId","value":"ENSP00000557113.1"},{"key":"GeneId","value":"ENSG00000117335.22"}],"isoformId":"P15529-12"},{"database":"Ensembl","id":"ENST00000887055.1","properties":[{"key":"ProteinId","value":"ENSP00000557114.1"},{"key":"GeneId","value":"ENSG00000117335.22"}],"isoformId":"P15529-14"},{"database":"Ensembl","id":"ENST00000887057.1","properties":[{"key":"ProteinId","value":"ENSP00000557116.1"},{"key":"GeneId","value":"ENSG00000117335.22"}],"isoformId":"P15529-13"},{"database":"Ensembl","id":"ENST00000970372.1","properties":[{"key":"ProteinId","value":"ENSP00000640431.1"},{"key":"GeneId","value":"ENSG00000117335.22"}],"isoformId":"P15529-11"},{"database":"Ensembl","id":"ENST00000970376.1","properties":[{"key":"ProteinId","value":"ENSP00000640435.1"},{"key":"GeneId","value":"ENSG00000117335.22"}],"isoformId":"P15529-14"},{"database":"Ensembl","id":"ENST00000970377.1","properties":[{"key":"ProteinId","value":"ENSP00000640436.1"},{"key":"GeneId","value":"ENSG00000117335.22"}],"isoformId":"P15529-12"},{"database":"GeneID","id":"4179","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:4179","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000367042.6","properties":[{"key":"ProteinId","value":"ENSP00000356009.1"},{"key":"RefSeqNucleotideId","value":"NM_172351.3"},{"key":"RefSeqProteinId","value":"NP_758861.1"}],"isoformId":"P15529-11"},{"database":"UCSC","id":"uc001hgc.4","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"P15529-1"},{"database":"AGR","id":"HGNC:6953","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA30700","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"4179","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"4179","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"CD46","properties":[{"key":"Description","value":"-"}]},{"database":"GeneReviews","id":"CD46","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:6953","properties":[{"key":"GeneName","value":"CD46"}]},{"database":"HPA","id":"ENSG00000117335","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MalaCards","id":"CD46","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"120920","properties":[{"key":"Type","value":"gene+phenotype"}]},{"database":"MIM","id":"612922","properties":[{"key":"Type","value":"phenotype"}]},{"database":"OpenTargets","id":"ENSG00000117335","properties":[{"key":"Description","value":"-"}]},{"database":"Orphanet","id":"544472","properties":[{"key":"Disease","value":"Atypical hemolytic uremic syndrome with complement gene abnormality"}]},{"database":"Orphanet","id":"244242","properties":[{"key":"Disease","value":"HELLP syndrome"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000117335","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502QPUC","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000161381","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_020107_1_2_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P15529","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"CVKGPRP","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"6480633at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"P15529","properties":[{"key":"Number of GO annotations","value":"4 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"P15529","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"P15529","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-977606","properties":[{"key":"PathwayName","value":"Regulation of Complement cascade"}]},{"database":"SignaLink","id":"P15529","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"P15529","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000117335","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"4179","properties":[{"key":"hits","value":"32 hits in 1167 CRISPR screens"}]},{"database":"ChiTaRS","id":"CD46","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"P15529","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"CD46","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"4179","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"P15529","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:P15529","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"RNAct","id":"P15529","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000117335","properties":[{"key":"ExpressionPatterns","value":"Expressed in palpebral conjunctiva and 213 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"P15529","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0009986","properties":[{"key":"GoTerm","value":"C:cell surface"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"23086448"}]},{"database":"GO","id":"GO:0070062","properties":[{"key":"GoTerm","value":"C:extracellular exosome"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"20458337"}]},{"database":"GO","id":"GO:0005925","properties":[{"key":"GoTerm","value":"C:focal adhesion"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"21423176"}]},{"database":"GO","id":"GO:0002079","properties":[{"key":"GoTerm","value":"C:inner acrosomal membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IDA:AgBase"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20534589"}]},{"database":"GO","id":"GO:0045296","properties":[{"key":"GoTerm","value":"F:cadherin binding"},{"key":"GoEvidenceType","value":"IPI:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"23086448"}]},{"database":"GO","id":"GO:0140311","properties":[{"key":"GoTerm","value":"F:protein sequestering activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"23086448"}]},{"database":"GO","id":"GO:0038023","properties":[{"key":"GoTerm","value":"F:signaling receptor activity"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"8402913"}]},{"database":"GO","id":"GO:0002250","properties":[{"key":"GoTerm","value":"P:adaptive immune response"},{"key":"GoEvidenceType","value":"IC:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"12540904"}]},{"database":"GO","id":"GO:0045959","properties":[{"key":"GoTerm","value":"P:negative regulation of complement activation, classical pathway"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0032733","properties":[{"key":"GoTerm","value":"P:positive regulation of interleukin-10 production"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12540904"}]},{"database":"GO","id":"GO:0043382","properties":[{"key":"GoTerm","value":"P:positive regulation of memory T cell differentiation"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12540904"}]},{"database":"GO","id":"GO:0045591","properties":[{"key":"GoTerm","value":"P:positive regulation of regulatory T cell differentiation"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12540904"}]},{"database":"GO","id":"GO:0042102","properties":[{"key":"GoTerm","value":"P:positive regulation of T cell proliferation"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12540904"}]},{"database":"GO","id":"GO:0071636","properties":[{"key":"GoTerm","value":"P:positive regulation of transforming growth factor beta production"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12540904"}]},{"database":"GO","id":"GO:0008593","properties":[{"key":"GoTerm","value":"P:regulation of Notch signaling pathway"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"23086448"}]},{"database":"GO","id":"GO:0002456","properties":[{"key":"GoTerm","value":"P:T cell mediated immunity"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"23086448"}]},{"database":"CDD","id":"cd00033","properties":[{"key":"EntryName","value":"CCP"},{"key":"MatchStatus","value":"4"}]},{"database":"FunFam","id":"2.10.70.10:FF:000014","properties":[{"key":"EntryName","value":"Membrane cofactor protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.70.10:FF:000042","properties":[{"key":"EntryName","value":"Membrane cofactor protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.70.10:FF:000046","properties":[{"key":"EntryName","value":"Membrane cofactor protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.70.10:FF:000080","properties":[{"key":"EntryName","value":"Membrane cofactor protein"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.10.70.10","properties":[{"key":"EntryName","value":"Complement Module, domain 1"},{"key":"MatchStatus","value":"4"}]},{"database":"InterPro","id":"IPR017341","properties":[{"key":"EntryName","value":"CD46"}]},{"database":"InterPro","id":"IPR051277","properties":[{"key":"EntryName","value":"SEZ6_CSMD_C4BPB_Regulators"}]},{"database":"InterPro","id":"IPR035976","properties":[{"key":"EntryName","value":"Sushi/SCR/CCP_sf"}]},{"database":"InterPro","id":"IPR000436","properties":[{"key":"EntryName","value":"Sushi_SCR_CCP_dom"}]},{"database":"PANTHER","id":"PTHR45656","properties":[{"key":"EntryName","value":"PROTEIN CBR-CLEC-78"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR45656:SF15","properties":[{"key":"EntryName","value":"SUSHI DOMAIN-CONTAINING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00084","properties":[{"key":"EntryName","value":"Sushi"},{"key":"MatchStatus","value":"4"}]},{"database":"PIRSF","id":"PIRSF037971","properties":[{"key":"EntryName","value":"TLX_CD46"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00032","properties":[{"key":"EntryName","value":"CCP"},{"key":"MatchStatus","value":"4"}]},{"database":"SUPFAM","id":"SSF57535","properties":[{"key":"EntryName","value":"Complement control module/SCR domain"},{"key":"MatchStatus","value":"4"}]},{"database":"PROSITE","id":"PS50923","properties":[{"key":"EntryName","value":"SUSHI"},{"key":"MatchStatus","value":"4"}]}],"sequence":{"value":"MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSSTKPPALSHSVSTSSTTKSPASSASGPRPTYKPPVSNYPGYPKPEEGILDSLDVWVIAVIVIAIVVGVAVICVVPYRYLQRRKKKGTYLTDETHREVKFTSL","length":392,"molWeight":43747,"crc64":"85FE0CF100EA703E","md5":"59124F3325DB843886A64AEA234DA6F7"},"extraAttributes":{"countByCommentType":{"FUNCTION":7,"SUBUNIT":5,"INTERACTION":24,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":16,"TISSUE SPECIFICITY":1,"DOMAIN":1,"PTM":3,"DISEASE":1},"countByFeatureType":{"Signal":1,"Chain":1,"Topological domain":2,"Transmembrane":1,"Domain":4,"Region":1,"Compositional bias":1,"Glycosylation":21,"Disulfide bond":8,"Alternative sequence":11,"Natural variant":13,"Mutagenesis":3,"Sequence conflict":4,"Helix":11,"Beta strand":27,"Modified residue":7},"uniParcId":"UPI0000160DF2"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A8Q3WLA6","uniProtkbId":"A0A8Q3WLA6_HUMAN","entryAudit":{"firstPublicDate":"2022-10-12","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2022-10-12","entryVersion":20,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000512167.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00017517"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR037971"}],"value":"Membrane cofactor protein"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000512167.1"}],"value":"CD46"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00025258"}],"value":"Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047055"}],"value":"Interacts with C3b. Interacts with C4b. Interacts with moesin/MSN"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004537"}],"value":"Cytoplasmic vesicle, secretory vesicle, acrosome inner membrane","id":"SL-0004"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004537"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00302"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":34,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":35,"modifier":"EXACT"},"end":{"value":373,"modifier":"EXACT"}},"description":"Membrane cofactor protein","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5047982108"},{"type":"Domain","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":96,"modifier":"EXACT"}},"description":"Sushi","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50923"}]},{"type":"Domain","location":{"start":{"value":97,"modifier":"EXACT"},"end":{"value":159,"modifier":"EXACT"}},"description":"Sushi","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50923"}]},{"type":"Domain","location":{"start":{"value":160,"modifier":"EXACT"},"end":{"value":225,"modifier":"EXACT"}},"description":"Sushi","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50923"}]},{"type":"Domain","location":{"start":{"value":226,"modifier":"EXACT"},"end":{"value":285,"modifier":"EXACT"}},"description":"Sushi","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50923"}]},{"type":"Region","location":{"start":{"value":286,"modifier":"EXACT"},"end":{"value":313,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":287,"modifier":"EXACT"},"end":{"value":300,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Disulfide bond","location":{"start":{"value":256,"modifier":"EXACT"},"end":{"value":283,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00302"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022875"}],"id":"KW-0180","category":"Biological process","name":"Complement pathway"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023329"}],"id":"KW-0968","category":"Cellular component","name":"Cytoplasmic vesicle"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00302"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023279"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR037971"}],"id":"KW-0278","category":"Biological process","name":"Fertilization"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022859"}],"id":"KW-0391","category":"Biological process","name":"Immunity"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022588"}],"id":"KW-0399","category":"Biological process","name":"Innate immunity"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR037971"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0A8Q3WLA6"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0A8Q3WLA6"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022659"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00302"}],"id":"KW-0768","category":"Domain","name":"Sushi"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000512167.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000512167.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16710414","citationType":"journal article","authors":["Gregory S.G.","Barlow K.F.","McLay K.E.","Kaul R.","Swarbreck D.","Dunham A.","Scott C.E.","Howe K.L.","Woodfine K.","Spencer C.C.","Jones M.C.","Gillson C.","Searle S.","Zhou Y.","Kokocinski F.","McDonald L.","Evans R.","Phillips K.","Atkinson A.","Cooper R.","Jones C.","Hall R.E.","Andrews T.D.","Lloyd C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Anderson F.","Andrew R.W.","Ashwell R.I.","Aubin K.","Babbage A.K.","Bagguley C.L.","Bailey J.","Beasley H.","Bethel G.","Bird C.P.","Bray-Allen S.","Brown J.Y.","Brown A.J.","Buckley D.","Burton J.","Bye J.","Carder C.","Chapman J.C.","Clark S.Y.","Clarke G.","Clee C.","Cobley V.","Collier R.E.","Corby N.","Coville G.J.","Davies J.","Deadman R.","Dunn M.","Earthrowl M.","Ellington A.G.","Errington H.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Gay L.","Ghori M.R.","Gibson R.","Gilby L.M.","Gillett W.","Glithero R.J.","Grafham D.V.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Hammond S.","Harrison E.S.","Hart E.","Haugen E.","Heath P.D.","Holmes S.","Holt K.","Howden P.J.","Hunt A.R.","Hunt S.E.","Hunter G.","Isherwood J.","James R.","Johnson C.","Johnson D.","Joy A.","Kay M.","Kershaw J.K.","Kibukawa M.","Kimberley A.M.","King A.","Knights A.J.","Lad H.","Laird G.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Loveland J.","Lovell J.","Lush M.J.","Lyne R.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","Matthews N.S.","McLaren S.","Milne S.","Mistry S.","Moore M.J.","Nickerson T.","O'Dell C.N.","Oliver K.","Palmeiri A.","Palmer S.A.","Parker A.","Patel D.","Pearce A.V.","Peck A.I.","Pelan S.","Phelps K.","Phillimore B.J.","Plumb R.","Rajan J.","Raymond C.","Rouse G.","Saenphimmachak C.","Sehra H.K.","Sheridan E.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.","Steward C.","Subramanian S.","Sycamore N.","Tracey A.","Tromans A.","Van Helmond Z.","Wall M.","Wallis J.M.","White S.","Whitehead S.L.","Wilkinson J.E.","Willey D.L.","Williams H.","Wilming L.","Wray P.W.","Wu Z.","Coulson A.","Vaudin M.","Sulston J.E.","Durbin R.","Hubbard T.","Wooster R.","Dunham I.","Carter N.P.","McVean G.","Ross M.T.","Harrow J.","Olson M.V.","Beck S.","Rogers J.","Bentley D.R.","Banerjee R.","Bryant S.P.","Burford D.C.","Burrill W.D.","Clegg S.M.","Dhami P.","Dovey O.","Faulkner L.M.","Gribble S.M.","Langford C.F.","Pandian R.D.","Porter K.M.","Prigmore E."],"citationCrossReferences":[{"database":"PubMed","id":"16710414"},{"database":"DOI","id":"10.1038/nature04727"}],"title":"The DNA sequence and biological annotation of human chromosome 1.","publicationDate":"2006","journal":"Nature","firstPage":"315","lastPage":"321","volume":"441"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000512167.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000512167.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL035209","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL365178","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"NP_758868.1","properties":[{"key":"NucleotideSequenceId","value":"NM_172358.3"}]},{"database":"AlphaFoldDB","id":"A0A8Q3WLA6","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0A8Q3WLA6","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000695777.1","properties":[{"key":"ProteinId","value":"ENSP00000512167.1"},{"key":"GeneId","value":"ENSG00000117335.22"}]},{"database":"GeneID","id":"4179","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"4179","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:6953","properties":[{"key":"GeneName","value":"CD46"}]},{"database":"OpenTargets","id":"ENSG00000117335","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000161381","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"6480633at2759","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"GO","id":"GO:0009986","properties":[{"key":"GoTerm","value":"C:cell surface"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0002079","properties":[{"key":"GoTerm","value":"C:inner acrosomal membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0050776","properties":[{"key":"GoTerm","value":"P:regulation of immune response"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0007338","properties":[{"key":"GoTerm","value":"P:single fertilization"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"CDD","id":"cd00033","properties":[{"key":"EntryName","value":"CCP"},{"key":"MatchStatus","value":"4"}]},{"database":"FunFam","id":"2.10.70.10:FF:000014","properties":[{"key":"EntryName","value":"Membrane cofactor protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.70.10:FF:000042","properties":[{"key":"EntryName","value":"Membrane cofactor protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.70.10:FF:000046","properties":[{"key":"EntryName","value":"Membrane cofactor protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.70.10:FF:000080","properties":[{"key":"EntryName","value":"Membrane cofactor protein"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.10.70.10","properties":[{"key":"EntryName","value":"Complement Module, domain 1"},{"key":"MatchStatus","value":"4"}]},{"database":"InterPro","id":"IPR017341","properties":[{"key":"EntryName","value":"CD46"}]},{"database":"InterPro","id":"IPR050350","properties":[{"key":"EntryName","value":"Compl-Cell_Adhes-Reg"}]},{"database":"InterPro","id":"IPR035976","properties":[{"key":"EntryName","value":"Sushi/SCR/CCP_sf"}]},{"database":"InterPro","id":"IPR000436","properties":[{"key":"EntryName","value":"Sushi_SCR_CCP_dom"}]},{"database":"PANTHER","id":"PTHR19325","properties":[{"key":"EntryName","value":"COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR19325:SF521","properties":[{"key":"EntryName","value":"MEMBRANE COFACTOR PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00084","properties":[{"key":"EntryName","value":"Sushi"},{"key":"MatchStatus","value":"4"}]},{"database":"PIRSF","id":"PIRSF037971","properties":[{"key":"EntryName","value":"TLX_CD46"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00032","properties":[{"key":"EntryName","value":"CCP"},{"key":"MatchStatus","value":"4"}]},{"database":"SUPFAM","id":"SSF57535","properties":[{"key":"EntryName","value":"Complement control module/SCR domain"},{"key":"MatchStatus","value":"4"}]},{"database":"PROSITE","id":"PS50923","properties":[{"key":"EntryName","value":"SUSHI"},{"key":"MatchStatus","value":"4"}]}],"sequence":{"value":"MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSASGPRPTYKPPVSNYPGYPKPEEGILDSLDVWVIAVIVIAIDIFKGGRRKGKQMVELNMPLTRLNQPLQQSREAE","length":373,"molWeight":41763,"crc64":"3FE3489FFA84023F","md5":"F29365685C53F47FA22C8A85116C4423"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":4,"Region":1,"Compositional bias":1,"Disulfide bond":1},"uniParcId":"UPI000002ADBD"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A8Q3WLU6","uniProtkbId":"A0A8Q3WLU6_HUMAN","entryAudit":{"firstPublicDate":"2022-10-12","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2022-10-12","entryVersion":20,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000512171.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00017517"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR037971"}],"value":"Membrane cofactor protein"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000512171.1"}],"value":"CD46"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00025258"}],"value":"Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047055"}],"value":"Interacts with C3b. Interacts with C4b. Interacts with moesin/MSN"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004537"}],"value":"Cytoplasmic vesicle, secretory vesicle, acrosome inner membrane","id":"SL-0004"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004537"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00302"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":34,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":35,"modifier":"EXACT"},"end":{"value":358,"modifier":"EXACT"}},"description":"Membrane cofactor protein","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5035866649"},{"type":"Domain","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":96,"modifier":"EXACT"}},"description":"Sushi","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50923"}]},{"type":"Domain","location":{"start":{"value":97,"modifier":"EXACT"},"end":{"value":159,"modifier":"EXACT"}},"description":"Sushi","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50923"}]},{"type":"Domain","location":{"start":{"value":160,"modifier":"EXACT"},"end":{"value":225,"modifier":"EXACT"}},"description":"Sushi","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50923"}]},{"type":"Domain","location":{"start":{"value":226,"modifier":"EXACT"},"end":{"value":285,"modifier":"EXACT"}},"description":"Sushi","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50923"}]},{"type":"Disulfide bond","location":{"start":{"value":256,"modifier":"EXACT"},"end":{"value":283,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00302"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022875"}],"id":"KW-0180","category":"Biological process","name":"Complement pathway"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023329"}],"id":"KW-0968","category":"Cellular component","name":"Cytoplasmic vesicle"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00302"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023279"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR037971"}],"id":"KW-0278","category":"Biological process","name":"Fertilization"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022859"}],"id":"KW-0391","category":"Biological process","name":"Immunity"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022588"}],"id":"KW-0399","category":"Biological process","name":"Innate immunity"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR037971"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0A8Q3WLU6"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0A8Q3WLU6"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022659"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00302"}],"id":"KW-0768","category":"Domain","name":"Sushi"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000512171.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000512171.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16710414","citationType":"journal article","authors":["Gregory S.G.","Barlow K.F.","McLay K.E.","Kaul R.","Swarbreck D.","Dunham A.","Scott C.E.","Howe K.L.","Woodfine K.","Spencer C.C.","Jones M.C.","Gillson C.","Searle S.","Zhou Y.","Kokocinski F.","McDonald L.","Evans R.","Phillips K.","Atkinson A.","Cooper R.","Jones C.","Hall R.E.","Andrews T.D.","Lloyd C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Anderson F.","Andrew R.W.","Ashwell R.I.","Aubin K.","Babbage A.K.","Bagguley C.L.","Bailey J.","Beasley H.","Bethel G.","Bird C.P.","Bray-Allen S.","Brown J.Y.","Brown A.J.","Buckley D.","Burton J.","Bye J.","Carder C.","Chapman J.C.","Clark S.Y.","Clarke G.","Clee C.","Cobley V.","Collier R.E.","Corby N.","Coville G.J.","Davies J.","Deadman R.","Dunn M.","Earthrowl M.","Ellington A.G.","Errington H.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Gay L.","Ghori M.R.","Gibson R.","Gilby L.M.","Gillett W.","Glithero R.J.","Grafham D.V.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Hammond S.","Harrison E.S.","Hart E.","Haugen E.","Heath P.D.","Holmes S.","Holt K.","Howden P.J.","Hunt A.R.","Hunt S.E.","Hunter G.","Isherwood J.","James R.","Johnson C.","Johnson D.","Joy A.","Kay M.","Kershaw J.K.","Kibukawa M.","Kimberley A.M.","King A.","Knights A.J.","Lad H.","Laird G.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Loveland J.","Lovell J.","Lush M.J.","Lyne R.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","Matthews N.S.","McLaren S.","Milne S.","Mistry S.","Moore M.J.","Nickerson T.","O'Dell C.N.","Oliver K.","Palmeiri A.","Palmer S.A.","Parker A.","Patel D.","Pearce A.V.","Peck A.I.","Pelan S.","Phelps K.","Phillimore B.J.","Plumb R.","Rajan J.","Raymond C.","Rouse G.","Saenphimmachak C.","Sehra H.K.","Sheridan E.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.","Steward C.","Subramanian S.","Sycamore N.","Tracey A.","Tromans A.","Van Helmond Z.","Wall M.","Wallis J.M.","White S.","Whitehead S.L.","Wilkinson J.E.","Willey D.L.","Williams H.","Wilming L.","Wray P.W.","Wu Z.","Coulson A.","Vaudin M.","Sulston J.E.","Durbin R.","Hubbard T.","Wooster R.","Dunham I.","Carter N.P.","McVean G.","Ross M.T.","Harrow J.","Olson M.V.","Beck S.","Rogers J.","Bentley D.R.","Banerjee R.","Bryant S.P.","Burford D.C.","Burrill W.D.","Clegg S.M.","Dhami P.","Dovey O.","Faulkner L.M.","Gribble S.M.","Langford C.F.","Pandian R.D.","Porter K.M.","Prigmore E."],"citationCrossReferences":[{"database":"PubMed","id":"16710414"},{"database":"DOI","id":"10.1038/nature04727"}],"title":"The DNA sequence and biological annotation of human chromosome 1.","publicationDate":"2006","journal":"Nature","firstPage":"315","lastPage":"321","volume":"441"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000512171.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000512171.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL035209","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL365178","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A8Q3WLU6","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0A8Q3WLU6","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000695782.1","properties":[{"key":"ProteinId","value":"ENSP00000512171.1"},{"key":"GeneId","value":"ENSG00000117335.22"}]},{"database":"HGNC","id":"HGNC:6953","properties":[{"key":"GeneName","value":"CD46"}]},{"database":"GeneTree","id":"ENSGT00940000161381","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"6480633at2759","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"ExpressionAtlas","id":"A0A8Q3WLU6","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0009986","properties":[{"key":"GoTerm","value":"C:cell surface"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0002079","properties":[{"key":"GoTerm","value":"C:inner acrosomal membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0050776","properties":[{"key":"GoTerm","value":"P:regulation of immune response"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0007338","properties":[{"key":"GoTerm","value":"P:single fertilization"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"CDD","id":"cd00033","properties":[{"key":"EntryName","value":"CCP"},{"key":"MatchStatus","value":"4"}]},{"database":"FunFam","id":"2.10.70.10:FF:000014","properties":[{"key":"EntryName","value":"Membrane cofactor protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.70.10:FF:000042","properties":[{"key":"EntryName","value":"Membrane cofactor protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.70.10:FF:000046","properties":[{"key":"EntryName","value":"Membrane cofactor protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.70.10:FF:000080","properties":[{"key":"EntryName","value":"Membrane cofactor protein"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.10.70.10","properties":[{"key":"EntryName","value":"Complement Module, domain 1"},{"key":"MatchStatus","value":"4"}]},{"database":"InterPro","id":"IPR017341","properties":[{"key":"EntryName","value":"CD46"}]},{"database":"InterPro","id":"IPR051277","properties":[{"key":"EntryName","value":"SEZ6_CSMD_C4BPB_Regulators"}]},{"database":"InterPro","id":"IPR035976","properties":[{"key":"EntryName","value":"Sushi/SCR/CCP_sf"}]},{"database":"InterPro","id":"IPR000436","properties":[{"key":"EntryName","value":"Sushi_SCR_CCP_dom"}]},{"database":"PANTHER","id":"PTHR45656","properties":[{"key":"EntryName","value":"PROTEIN CBR-CLEC-78"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR45656:SF4","properties":[{"key":"EntryName","value":"PROTEIN CBR-CLEC-78"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00084","properties":[{"key":"EntryName","value":"Sushi"},{"key":"MatchStatus","value":"4"}]},{"database":"PIRSF","id":"PIRSF037971","properties":[{"key":"EntryName","value":"TLX_CD46"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00032","properties":[{"key":"EntryName","value":"CCP"},{"key":"MatchStatus","value":"4"}]},{"database":"SUPFAM","id":"SSF57535","properties":[{"key":"EntryName","value":"Complement control module/SCR domain"},{"key":"MatchStatus","value":"4"}]},{"database":"PROSITE","id":"PS50923","properties":[{"key":"EntryName","value":"SUSHI"},{"key":"MatchStatus","value":"4"}]}],"sequence":{"value":"MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKGPRPTYKPPVSNYPGYPKPEEGILDSLDVWVIAVIVIAIDIFKGGRRKGKQMVELNMPLTRLNQPLQQSREAE","length":358,"molWeight":40383,"crc64":"8D5C31B51D68EE72","md5":"E0F55BE2500F8E2A63DC60AD7F93B6C0"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":4,"Disulfide bond":1},"uniParcId":"UPI001FC1DB35"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8Q7J5","uniProtkbId":"A0ACI8Q7J5_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000557115.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00017517"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR037971"}],"value":"Membrane cofactor protein"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000557115.1"}],"value":"CD46"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00025258"}],"value":"Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047055"}],"value":"Interacts with C3b. Interacts with C4b. Interacts with moesin/MSN"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004537"}],"value":"Cytoplasmic vesicle, secretory vesicle, acrosome inner membrane","id":"SL-0004"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004537"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00302"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":34,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":35,"modifier":"EXACT"},"end":{"value":356,"modifier":"EXACT"}},"description":"Membrane cofactor protein","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5051419894"},{"type":"Transmembrane","location":{"start":{"value":308,"modifier":"EXACT"},"end":{"value":330,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":96,"modifier":"EXACT"}},"description":"Sushi","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50923"}]},{"type":"Domain","location":{"start":{"value":153,"modifier":"EXACT"},"end":{"value":218,"modifier":"EXACT"}},"description":"Sushi","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50923"}]},{"type":"Domain","location":{"start":{"value":219,"modifier":"EXACT"},"end":{"value":278,"modifier":"EXACT"}},"description":"Sushi","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50923"}]},{"type":"Disulfide bond","location":{"start":{"value":249,"modifier":"EXACT"},"end":{"value":276,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00302"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022875"}],"id":"KW-0180","category":"Biological process","name":"Complement pathway"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023329"}],"id":"KW-0968","category":"Cellular component","name":"Cytoplasmic vesicle"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00302"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023279"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR037971"}],"id":"KW-0278","category":"Biological process","name":"Fertilization"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022859"}],"id":"KW-0391","category":"Biological process","name":"Immunity"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022588"}],"id":"KW-0399","category":"Biological process","name":"Innate immunity"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR037971"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8Q7J5"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8Q7J5"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022659"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00302"}],"id":"KW-0768","category":"Domain","name":"Sushi"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000557115.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000557115.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16710414","citationType":"journal article","authors":["Gregory S.G.","Barlow K.F.","McLay K.E.","Kaul R.","Swarbreck D.","Dunham A.","Scott C.E.","Howe K.L.","Woodfine K.","Spencer C.C.","Jones M.C.","Gillson C.","Searle S.","Zhou Y.","Kokocinski F.","McDonald L.","Evans R.","Phillips K.","Atkinson A.","Cooper R.","Jones C.","Hall R.E.","Andrews T.D.","Lloyd C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Anderson F.","Andrew R.W.","Ashwell R.I.","Aubin K.","Babbage A.K.","Bagguley C.L.","Bailey J.","Beasley H.","Bethel G.","Bird C.P.","Bray-Allen S.","Brown J.Y.","Brown A.J.","Buckley D.","Burton J.","Bye J.","Carder C.","Chapman J.C.","Clark S.Y.","Clarke G.","Clee C.","Cobley V.","Collier R.E.","Corby N.","Coville G.J.","Davies J.","Deadman R.","Dunn M.","Earthrowl M.","Ellington A.G.","Errington H.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Gay L.","Ghori M.R.","Gibson R.","Gilby L.M.","Gillett W.","Glithero R.J.","Grafham D.V.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Hammond S.","Harrison E.S.","Hart E.","Haugen E.","Heath P.D.","Holmes S.","Holt K.","Howden P.J.","Hunt A.R.","Hunt S.E.","Hunter G.","Isherwood J.","James R.","Johnson C.","Johnson D.","Joy A.","Kay M.","Kershaw J.K.","Kibukawa M.","Kimberley A.M.","King A.","Knights A.J.","Lad H.","Laird G.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Loveland J.","Lovell J.","Lush M.J.","Lyne R.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","Matthews N.S.","McLaren S.","Milne S.","Mistry S.","Moore M.J.","Nickerson T.","O'Dell C.N.","Oliver K.","Palmeiri A.","Palmer S.A.","Parker A.","Patel D.","Pearce A.V.","Peck A.I.","Pelan S.","Phelps K.","Phillimore B.J.","Plumb R.","Rajan J.","Raymond C.","Rouse G.","Saenphimmachak C.","Sehra H.K.","Sheridan E.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.","Steward C.","Subramanian S.","Sycamore N.","Tracey A.","Tromans A.","Van Helmond Z.","Wall M.","Wallis J.M.","White S.","Whitehead S.L.","Wilkinson J.E.","Willey D.L.","Williams H.","Wilming L.","Wray P.W.","Wu Z.","Coulson A.","Vaudin M.","Sulston J.E.","Durbin R.","Hubbard T.","Wooster R.","Dunham I.","Carter N.P.","McVean G.","Ross M.T.","Harrow J.","Olson M.V.","Beck S.","Rogers J.","Bentley D.R.","Banerjee R.","Bryant S.P.","Burford D.C.","Burrill W.D.","Clegg S.M.","Dhami P.","Dovey O.","Faulkner L.M.","Gribble S.M.","Langford C.F.","Pandian R.D.","Porter K.M.","Prigmore E."],"citationCrossReferences":[{"database":"PubMed","id":"16710414"},{"database":"DOI","id":"10.1038/nature04727"}],"title":"The DNA sequence and biological annotation of human chromosome 1.","publicationDate":"2006","journal":"Nature","firstPage":"315","lastPage":"321","volume":"441"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000557115.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000557115.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL035209","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL365178","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000887056.1","properties":[{"key":"ProteinId","value":"ENSP00000557115.1"},{"key":"GeneId","value":"ENSG00000117335.22"}]},{"database":"HGNC","id":"HGNC:6953","properties":[{"key":"GeneName","value":"CD46"}]},{"database":"OpenTargets","id":"ENSG00000117335","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000161381","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"CDD","id":"cd00033","properties":[{"key":"EntryName","value":"CCP"},{"key":"MatchStatus","value":"4"}]},{"database":"FunFam","id":"2.10.70.10:FF:000014","properties":[{"key":"EntryName","value":"Membrane cofactor protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.70.10:FF:000042","properties":[{"key":"EntryName","value":"Membrane cofactor protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.70.10:FF:000046","properties":[{"key":"EntryName","value":"Membrane cofactor protein"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.10.70.10","properties":[{"key":"EntryName","value":"Complement Module, domain 1"},{"key":"MatchStatus","value":"4"}]},{"database":"InterPro","id":"IPR017341","properties":[{"key":"EntryName","value":"CD46"}]},{"database":"InterPro","id":"IPR050350","properties":[{"key":"EntryName","value":"Compl-Cell_Adhes-Reg"}]},{"database":"InterPro","id":"IPR035976","properties":[{"key":"EntryName","value":"Sushi/SCR/CCP_sf"}]},{"database":"InterPro","id":"IPR000436","properties":[{"key":"EntryName","value":"Sushi_SCR_CCP_dom"}]},{"database":"PANTHER","id":"PTHR19325","properties":[{"key":"EntryName","value":"COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR19325:SF521","properties":[{"key":"EntryName","value":"MEMBRANE COFACTOR PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00084","properties":[{"key":"EntryName","value":"Sushi"},{"key":"MatchStatus","value":"4"}]},{"database":"PIRSF","id":"PIRSF037971","properties":[{"key":"EntryName","value":"TLX_CD46"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00032","properties":[{"key":"EntryName","value":"CCP"},{"key":"MatchStatus","value":"4"}]},{"database":"SUPFAM","id":"SSF57535","properties":[{"key":"EntryName","value":"Complement control module/SCR domain"},{"key":"MatchStatus","value":"4"}]},{"database":"PROSITE","id":"PS50923","properties":[{"key":"EntryName","value":"SUSHI"},{"key":"MatchStatus","value":"3"}]}],"sequence":{"value":"MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSEVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSASGYPKPEEGILDSLDVWVIAVIVIAIVVGVAVICVVPYRYLQRRKKKGTYLTDETHREVKFTSL","length":356,"molWeight":39969,"crc64":"B1B70181FCBC9E0A","md5":"223A44470702AF93491AD88C454FB7BF"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Transmembrane":1,"Domain":3,"Disulfide bond":1},"uniParcId":"UPI004031EADD"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8VR53","uniProtkbId":"A0ACI8VR53_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000640434.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00017517"}],"value":"Membrane cofactor protein"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000640434.1"}],"value":"CD46"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00025258"}],"value":"Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047055"}],"value":"Interacts with C3b. Interacts with C4b. Interacts with moesin/MSN"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004537"}],"value":"Cytoplasmic vesicle, secretory vesicle, acrosome inner membrane","id":"SL-0004"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004537"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00302"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":34,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":35,"modifier":"EXACT"},"end":{"value":311,"modifier":"EXACT"}},"description":"Membrane cofactor protein","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5051204207"},{"type":"Transmembrane","location":{"start":{"value":263,"modifier":"EXACT"},"end":{"value":285,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":96,"modifier":"EXACT"}},"description":"Sushi","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50923"}]},{"type":"Domain","location":{"start":{"value":97,"modifier":"EXACT"},"end":{"value":159,"modifier":"EXACT"}},"description":"Sushi","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50923"}]},{"type":"Domain","location":{"start":{"value":160,"modifier":"EXACT"},"end":{"value":219,"modifier":"EXACT"}},"description":"Sushi","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50923"}]},{"type":"Region","location":{"start":{"value":220,"modifier":"EXACT"},"end":{"value":247,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":221,"modifier":"EXACT"},"end":{"value":234,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Disulfide bond","location":{"start":{"value":190,"modifier":"EXACT"},"end":{"value":217,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00302"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022875"}],"id":"KW-0180","category":"Biological process","name":"Complement pathway"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023329"}],"id":"KW-0968","category":"Cellular component","name":"Cytoplasmic vesicle"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00302"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023279"}],"id":"KW-0278","category":"Biological process","name":"Fertilization"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022859"}],"id":"KW-0391","category":"Biological process","name":"Immunity"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022588"}],"id":"KW-0399","category":"Biological process","name":"Innate immunity"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8VR53"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8VR53"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022659"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00302"}],"id":"KW-0768","category":"Domain","name":"Sushi"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000640434.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000640434.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16710414","citationType":"journal article","authors":["Gregory S.G.","Barlow K.F.","McLay K.E.","Kaul R.","Swarbreck D.","Dunham A.","Scott C.E.","Howe K.L.","Woodfine K.","Spencer C.C.","Jones M.C.","Gillson C.","Searle S.","Zhou Y.","Kokocinski F.","McDonald L.","Evans R.","Phillips K.","Atkinson A.","Cooper R.","Jones C.","Hall R.E.","Andrews T.D.","Lloyd C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Anderson F.","Andrew R.W.","Ashwell R.I.","Aubin K.","Babbage A.K.","Bagguley C.L.","Bailey J.","Beasley H.","Bethel G.","Bird C.P.","Bray-Allen S.","Brown J.Y.","Brown A.J.","Buckley D.","Burton J.","Bye J.","Carder C.","Chapman J.C.","Clark S.Y.","Clarke G.","Clee C.","Cobley V.","Collier R.E.","Corby N.","Coville G.J.","Davies J.","Deadman R.","Dunn M.","Earthrowl M.","Ellington A.G.","Errington H.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Gay L.","Ghori M.R.","Gibson R.","Gilby L.M.","Gillett W.","Glithero R.J.","Grafham D.V.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Hammond S.","Harrison E.S.","Hart E.","Haugen E.","Heath P.D.","Holmes S.","Holt K.","Howden P.J.","Hunt A.R.","Hunt S.E.","Hunter G.","Isherwood J.","James R.","Johnson C.","Johnson D.","Joy A.","Kay M.","Kershaw J.K.","Kibukawa M.","Kimberley A.M.","King A.","Knights A.J.","Lad H.","Laird G.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Loveland J.","Lovell J.","Lush M.J.","Lyne R.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","Matthews N.S.","McLaren S.","Milne S.","Mistry S.","Moore M.J.","Nickerson T.","O'Dell C.N.","Oliver K.","Palmeiri A.","Palmer S.A.","Parker A.","Patel D.","Pearce A.V.","Peck A.I.","Pelan S.","Phelps K.","Phillimore B.J.","Plumb R.","Rajan J.","Raymond C.","Rouse G.","Saenphimmachak C.","Sehra H.K.","Sheridan E.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.","Steward C.","Subramanian S.","Sycamore N.","Tracey A.","Tromans A.","Van Helmond Z.","Wall M.","Wallis J.M.","White S.","Whitehead S.L.","Wilkinson J.E.","Willey D.L.","Williams H.","Wilming L.","Wray P.W.","Wu Z.","Coulson A.","Vaudin M.","Sulston J.E.","Durbin R.","Hubbard T.","Wooster R.","Dunham I.","Carter N.P.","McVean G.","Ross M.T.","Harrow J.","Olson M.V.","Beck S.","Rogers J.","Bentley D.R.","Banerjee R.","Bryant S.P.","Burford D.C.","Burrill W.D.","Clegg S.M.","Dhami P.","Dovey O.","Faulkner L.M.","Gribble S.M.","Langford C.F.","Pandian R.D.","Porter K.M.","Prigmore E."],"citationCrossReferences":[{"database":"PubMed","id":"16710414"},{"database":"DOI","id":"10.1038/nature04727"}],"title":"The DNA sequence and biological annotation of human chromosome 1.","publicationDate":"2006","journal":"Nature","firstPage":"315","lastPage":"321","volume":"441"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000640434.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000640434.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL035209","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL365178","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000970375.1","properties":[{"key":"ProteinId","value":"ENSP00000640434.1"},{"key":"GeneId","value":"ENSG00000117335.22"}]},{"database":"HGNC","id":"HGNC:6953","properties":[{"key":"GeneName","value":"CD46"}]},{"database":"OpenTargets","id":"ENSG00000117335","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000161381","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"CDD","id":"cd00033","properties":[{"key":"EntryName","value":"CCP"},{"key":"MatchStatus","value":"3"}]},{"database":"FunFam","id":"2.10.70.10:FF:000014","properties":[{"key":"EntryName","value":"Membrane cofactor protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.70.10:FF:000046","properties":[{"key":"EntryName","value":"Membrane cofactor protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.70.10:FF:000080","properties":[{"key":"EntryName","value":"Membrane cofactor protein"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.10.70.10","properties":[{"key":"EntryName","value":"Complement Module, domain 1"},{"key":"MatchStatus","value":"3"}]},{"database":"InterPro","id":"IPR017341","properties":[{"key":"EntryName","value":"CD46"}]},{"database":"InterPro","id":"IPR050350","properties":[{"key":"EntryName","value":"Compl-Cell_Adhes-Reg"}]},{"database":"InterPro","id":"IPR035976","properties":[{"key":"EntryName","value":"Sushi/SCR/CCP_sf"}]},{"database":"InterPro","id":"IPR000436","properties":[{"key":"EntryName","value":"Sushi_SCR_CCP_dom"}]},{"database":"PANTHER","id":"PTHR19325","properties":[{"key":"EntryName","value":"COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR19325:SF521","properties":[{"key":"EntryName","value":"MEMBRANE COFACTOR PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00084","properties":[{"key":"EntryName","value":"Sushi"},{"key":"MatchStatus","value":"3"}]},{"database":"PIRSF","id":"PIRSF037971","properties":[{"key":"EntryName","value":"TLX_CD46"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00032","properties":[{"key":"EntryName","value":"CCP"},{"key":"MatchStatus","value":"3"}]},{"database":"SUPFAM","id":"SSF57535","properties":[{"key":"EntryName","value":"Complement control module/SCR domain"},{"key":"MatchStatus","value":"3"}]},{"database":"PROSITE","id":"PS50923","properties":[{"key":"EntryName","value":"SUSHI"},{"key":"MatchStatus","value":"3"}]}],"sequence":{"value":"MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEMVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSASGPRPTYKPPVSNYPGYPKPEEGILDSLDVWVIAVIVIAIVVGVAVICVVPYRYLQRRKKKGTYLTDETHREVKFTSL","length":311,"molWeight":35091,"crc64":"71FDDCB3842F7172","md5":"0F68022E09D511E9876FB25D74AA6ECA"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Transmembrane":1,"Domain":3,"Region":1,"Compositional bias":1,"Disulfide bond":1},"uniParcId":"UPI004031D47C"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8VR80","uniProtkbId":"A0ACI8VR80_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000640433.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00017517"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR037971"}],"value":"Membrane cofactor protein"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000640433.1"}],"value":"CD46"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00025258"}],"value":"Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047055"}],"value":"Interacts with C3b. Interacts with C4b. Interacts with moesin/MSN"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004537"}],"value":"Cytoplasmic vesicle, secretory vesicle, acrosome inner membrane","id":"SL-0004"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004537"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00302"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":34,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":35,"modifier":"EXACT"},"end":{"value":365,"modifier":"EXACT"}},"description":"Membrane cofactor protein","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5051380301"},{"type":"Domain","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":96,"modifier":"EXACT"}},"description":"Sushi","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50923"}]},{"type":"Domain","location":{"start":{"value":97,"modifier":"EXACT"},"end":{"value":159,"modifier":"EXACT"}},"description":"Sushi","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50923"}]},{"type":"Domain","location":{"start":{"value":160,"modifier":"EXACT"},"end":{"value":225,"modifier":"EXACT"}},"description":"Sushi","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50923"}]},{"type":"Domain","location":{"start":{"value":226,"modifier":"EXACT"},"end":{"value":285,"modifier":"EXACT"}},"description":"Sushi","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50923"}]},{"type":"Region","location":{"start":{"value":287,"modifier":"EXACT"},"end":{"value":312,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":287,"modifier":"EXACT"},"end":{"value":300,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Disulfide bond","location":{"start":{"value":256,"modifier":"EXACT"},"end":{"value":283,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00302"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022875"}],"id":"KW-0180","category":"Biological process","name":"Complement pathway"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023329"}],"id":"KW-0968","category":"Cellular component","name":"Cytoplasmic vesicle"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00302"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023279"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR037971"}],"id":"KW-0278","category":"Biological process","name":"Fertilization"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022859"}],"id":"KW-0391","category":"Biological process","name":"Immunity"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022588"}],"id":"KW-0399","category":"Biological process","name":"Innate immunity"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR037971"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8VR80"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8VR80"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022659"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00302"}],"id":"KW-0768","category":"Domain","name":"Sushi"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000640433.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000640433.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16710414","citationType":"journal article","authors":["Gregory S.G.","Barlow K.F.","McLay K.E.","Kaul R.","Swarbreck D.","Dunham A.","Scott C.E.","Howe K.L.","Woodfine K.","Spencer C.C.","Jones M.C.","Gillson C.","Searle S.","Zhou Y.","Kokocinski F.","McDonald L.","Evans R.","Phillips K.","Atkinson A.","Cooper R.","Jones C.","Hall R.E.","Andrews T.D.","Lloyd C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Anderson F.","Andrew R.W.","Ashwell R.I.","Aubin K.","Babbage A.K.","Bagguley C.L.","Bailey J.","Beasley H.","Bethel G.","Bird C.P.","Bray-Allen S.","Brown J.Y.","Brown A.J.","Buckley D.","Burton J.","Bye J.","Carder C.","Chapman J.C.","Clark S.Y.","Clarke G.","Clee C.","Cobley V.","Collier R.E.","Corby N.","Coville G.J.","Davies J.","Deadman R.","Dunn M.","Earthrowl M.","Ellington A.G.","Errington H.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Gay L.","Ghori M.R.","Gibson R.","Gilby L.M.","Gillett W.","Glithero R.J.","Grafham D.V.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Hammond S.","Harrison E.S.","Hart E.","Haugen E.","Heath P.D.","Holmes S.","Holt K.","Howden P.J.","Hunt A.R.","Hunt S.E.","Hunter G.","Isherwood J.","James R.","Johnson C.","Johnson D.","Joy A.","Kay M.","Kershaw J.K.","Kibukawa M.","Kimberley A.M.","King A.","Knights A.J.","Lad H.","Laird G.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Loveland J.","Lovell J.","Lush M.J.","Lyne R.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","Matthews N.S.","McLaren S.","Milne S.","Mistry S.","Moore M.J.","Nickerson T.","O'Dell C.N.","Oliver K.","Palmeiri A.","Palmer S.A.","Parker A.","Patel D.","Pearce A.V.","Peck A.I.","Pelan S.","Phelps K.","Phillimore B.J.","Plumb R.","Rajan J.","Raymond C.","Rouse G.","Saenphimmachak C.","Sehra H.K.","Sheridan E.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.","Steward C.","Subramanian S.","Sycamore N.","Tracey A.","Tromans A.","Van Helmond Z.","Wall M.","Wallis J.M.","White S.","Whitehead S.L.","Wilkinson J.E.","Willey D.L.","Williams H.","Wilming L.","Wray P.W.","Wu Z.","Coulson A.","Vaudin M.","Sulston J.E.","Durbin R.","Hubbard T.","Wooster R.","Dunham I.","Carter N.P.","McVean G.","Ross M.T.","Harrow J.","Olson M.V.","Beck S.","Rogers J.","Bentley D.R.","Banerjee R.","Bryant S.P.","Burford D.C.","Burrill W.D.","Clegg S.M.","Dhami P.","Dovey O.","Faulkner L.M.","Gribble S.M.","Langford C.F.","Pandian R.D.","Porter K.M.","Prigmore E."],"citationCrossReferences":[{"database":"PubMed","id":"16710414"},{"database":"DOI","id":"10.1038/nature04727"}],"title":"The DNA sequence and biological annotation of human chromosome 1.","publicationDate":"2006","journal":"Nature","firstPage":"315","lastPage":"321","volume":"441"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000640433.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000640433.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL035209","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL365178","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000970374.1","properties":[{"key":"ProteinId","value":"ENSP00000640433.1"},{"key":"GeneId","value":"ENSG00000117335.22"}]},{"database":"HGNC","id":"HGNC:6953","properties":[{"key":"GeneName","value":"CD46"}]},{"database":"OpenTargets","id":"ENSG00000117335","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000161381","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"CDD","id":"cd00033","properties":[{"key":"EntryName","value":"CCP"},{"key":"MatchStatus","value":"4"}]},{"database":"FunFam","id":"2.10.70.10:FF:000014","properties":[{"key":"EntryName","value":"Membrane cofactor protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.70.10:FF:000042","properties":[{"key":"EntryName","value":"Membrane cofactor protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.70.10:FF:000046","properties":[{"key":"EntryName","value":"Membrane cofactor protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.70.10:FF:000080","properties":[{"key":"EntryName","value":"Membrane cofactor protein"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.10.70.10","properties":[{"key":"EntryName","value":"Complement Module, domain 1"},{"key":"MatchStatus","value":"4"}]},{"database":"InterPro","id":"IPR017341","properties":[{"key":"EntryName","value":"CD46"}]},{"database":"InterPro","id":"IPR050350","properties":[{"key":"EntryName","value":"Compl-Cell_Adhes-Reg"}]},{"database":"InterPro","id":"IPR035976","properties":[{"key":"EntryName","value":"Sushi/SCR/CCP_sf"}]},{"database":"InterPro","id":"IPR000436","properties":[{"key":"EntryName","value":"Sushi_SCR_CCP_dom"}]},{"database":"PANTHER","id":"PTHR19325","properties":[{"key":"EntryName","value":"COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR19325:SF521","properties":[{"key":"EntryName","value":"MEMBRANE COFACTOR PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00084","properties":[{"key":"EntryName","value":"Sushi"},{"key":"MatchStatus","value":"4"}]},{"database":"PIRSF","id":"PIRSF037971","properties":[{"key":"EntryName","value":"TLX_CD46"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00032","properties":[{"key":"EntryName","value":"CCP"},{"key":"MatchStatus","value":"4"}]},{"database":"SUPFAM","id":"SSF57535","properties":[{"key":"EntryName","value":"Complement control module/SCR domain"},{"key":"MatchStatus","value":"4"}]},{"database":"PROSITE","id":"PS50923","properties":[{"key":"EntryName","value":"SUSHI"},{"key":"MatchStatus","value":"4"}]}],"sequence":{"value":"MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSASGPRPTYKPPVSNYPGYPKPEEGILDSLVVGVAVICVVPYRYLQRRKKKGTYLTDETHREVKFTSL","length":365,"molWeight":40955,"crc64":"DF42FEB780625C91","md5":"A0B352B482357DFD943D349327532D15"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":4,"Region":1,"Compositional bias":1,"Disulfide bond":1},"uniParcId":"UPI0040317E2B"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A8Q3WKS6","uniProtkbId":"A0A8Q3WKS6_HUMAN","entryAudit":{"firstPublicDate":"2022-10-12","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2022-10-12","entryVersion":20,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000512172.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00017517"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR037971"}],"value":"Membrane cofactor protein"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000512172.1"}],"value":"CD46"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00025258"}],"value":"Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047055"}],"value":"Interacts with C3b. Interacts with C4b. Interacts with moesin/MSN"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004537"}],"value":"Cytoplasmic vesicle, secretory vesicle, acrosome inner membrane","id":"SL-0004"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004537"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00302"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":34,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":35,"modifier":"EXACT"},"end":{"value":334,"modifier":"EXACT"}},"description":"Membrane cofactor protein","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5035822984"},{"type":"Domain","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":96,"modifier":"EXACT"}},"description":"Sushi","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50923"}]},{"type":"Domain","location":{"start":{"value":97,"modifier":"EXACT"},"end":{"value":159,"modifier":"EXACT"}},"description":"Sushi","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50923"}]},{"type":"Domain","location":{"start":{"value":160,"modifier":"EXACT"},"end":{"value":225,"modifier":"EXACT"}},"description":"Sushi","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50923"}]},{"type":"Domain","location":{"start":{"value":226,"modifier":"EXACT"},"end":{"value":285,"modifier":"EXACT"}},"description":"Sushi","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50923"}]},{"type":"Disulfide bond","location":{"start":{"value":256,"modifier":"EXACT"},"end":{"value":283,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00302"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022875"}],"id":"KW-0180","category":"Biological process","name":"Complement pathway"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023329"}],"id":"KW-0968","category":"Cellular component","name":"Cytoplasmic vesicle"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00302"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023279"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR037971"}],"id":"KW-0278","category":"Biological process","name":"Fertilization"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022859"}],"id":"KW-0391","category":"Biological process","name":"Immunity"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022588"}],"id":"KW-0399","category":"Biological process","name":"Innate immunity"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR037971"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0A8Q3WKS6"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0A8Q3WKS6"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022659"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00302"}],"id":"KW-0768","category":"Domain","name":"Sushi"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000512172.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000512172.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16710414","citationType":"journal article","authors":["Gregory S.G.","Barlow K.F.","McLay K.E.","Kaul R.","Swarbreck D.","Dunham A.","Scott C.E.","Howe K.L.","Woodfine K.","Spencer C.C.","Jones M.C.","Gillson C.","Searle S.","Zhou Y.","Kokocinski F.","McDonald L.","Evans R.","Phillips K.","Atkinson A.","Cooper R.","Jones C.","Hall R.E.","Andrews T.D.","Lloyd C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Anderson F.","Andrew R.W.","Ashwell R.I.","Aubin K.","Babbage A.K.","Bagguley C.L.","Bailey J.","Beasley H.","Bethel G.","Bird C.P.","Bray-Allen S.","Brown J.Y.","Brown A.J.","Buckley D.","Burton J.","Bye J.","Carder C.","Chapman J.C.","Clark S.Y.","Clarke G.","Clee C.","Cobley V.","Collier R.E.","Corby N.","Coville G.J.","Davies J.","Deadman R.","Dunn M.","Earthrowl M.","Ellington A.G.","Errington H.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Gay L.","Ghori M.R.","Gibson R.","Gilby L.M.","Gillett W.","Glithero R.J.","Grafham D.V.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Hammond S.","Harrison E.S.","Hart E.","Haugen E.","Heath P.D.","Holmes S.","Holt K.","Howden P.J.","Hunt A.R.","Hunt S.E.","Hunter G.","Isherwood J.","James R.","Johnson C.","Johnson D.","Joy A.","Kay M.","Kershaw J.K.","Kibukawa M.","Kimberley A.M.","King A.","Knights A.J.","Lad H.","Laird G.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Loveland J.","Lovell J.","Lush M.J.","Lyne R.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","Matthews N.S.","McLaren S.","Milne S.","Mistry S.","Moore M.J.","Nickerson T.","O'Dell C.N.","Oliver K.","Palmeiri A.","Palmer S.A.","Parker A.","Patel D.","Pearce A.V.","Peck A.I.","Pelan S.","Phelps K.","Phillimore B.J.","Plumb R.","Rajan J.","Raymond C.","Rouse G.","Saenphimmachak C.","Sehra H.K.","Sheridan E.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.","Steward C.","Subramanian S.","Sycamore N.","Tracey A.","Tromans A.","Van Helmond Z.","Wall M.","Wallis J.M.","White S.","Whitehead S.L.","Wilkinson J.E.","Willey D.L.","Williams H.","Wilming L.","Wray P.W.","Wu Z.","Coulson A.","Vaudin M.","Sulston J.E.","Durbin R.","Hubbard T.","Wooster R.","Dunham I.","Carter N.P.","McVean G.","Ross M.T.","Harrow J.","Olson M.V.","Beck S.","Rogers J.","Bentley D.R.","Banerjee R.","Bryant S.P.","Burford D.C.","Burrill W.D.","Clegg S.M.","Dhami P.","Dovey O.","Faulkner L.M.","Gribble S.M.","Langford C.F.","Pandian R.D.","Porter K.M.","Prigmore E."],"citationCrossReferences":[{"database":"PubMed","id":"16710414"},{"database":"DOI","id":"10.1038/nature04727"}],"title":"The DNA sequence and biological annotation of human chromosome 1.","publicationDate":"2006","journal":"Nature","firstPage":"315","lastPage":"321","volume":"441"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000512172.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000512172.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL035209","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL365178","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A8Q3WKS6","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0A8Q3WKS6","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000695784.1","properties":[{"key":"ProteinId","value":"ENSP00000512172.1"},{"key":"GeneId","value":"ENSG00000117335.22"}]},{"database":"HGNC","id":"HGNC:6953","properties":[{"key":"GeneName","value":"CD46"}]},{"database":"GeneTree","id":"ENSGT00940000161381","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"6480633at2759","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"ExpressionAtlas","id":"A0A8Q3WKS6","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0009986","properties":[{"key":"GoTerm","value":"C:cell surface"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0002079","properties":[{"key":"GoTerm","value":"C:inner acrosomal membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0050776","properties":[{"key":"GoTerm","value":"P:regulation of immune response"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0007338","properties":[{"key":"GoTerm","value":"P:single fertilization"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"CDD","id":"cd00033","properties":[{"key":"EntryName","value":"CCP"},{"key":"MatchStatus","value":"4"}]},{"database":"FunFam","id":"2.10.70.10:FF:000014","properties":[{"key":"EntryName","value":"Membrane cofactor protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.70.10:FF:000042","properties":[{"key":"EntryName","value":"Membrane cofactor protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.70.10:FF:000046","properties":[{"key":"EntryName","value":"Membrane cofactor protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.70.10:FF:000080","properties":[{"key":"EntryName","value":"Membrane cofactor protein"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.10.70.10","properties":[{"key":"EntryName","value":"Complement Module, domain 1"},{"key":"MatchStatus","value":"4"}]},{"database":"InterPro","id":"IPR017341","properties":[{"key":"EntryName","value":"CD46"}]},{"database":"InterPro","id":"IPR050350","properties":[{"key":"EntryName","value":"Compl-Cell_Adhes-Reg"}]},{"database":"InterPro","id":"IPR035976","properties":[{"key":"EntryName","value":"Sushi/SCR/CCP_sf"}]},{"database":"InterPro","id":"IPR000436","properties":[{"key":"EntryName","value":"Sushi_SCR_CCP_dom"}]},{"database":"PANTHER","id":"PTHR19325","properties":[{"key":"EntryName","value":"COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR19325:SF521","properties":[{"key":"EntryName","value":"MEMBRANE COFACTOR PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00084","properties":[{"key":"EntryName","value":"Sushi"},{"key":"MatchStatus","value":"4"}]},{"database":"PIRSF","id":"PIRSF037971","properties":[{"key":"EntryName","value":"TLX_CD46"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR02045","properties":[{"key":"EntryName","value":"F138DOMAIN"}]},{"database":"SMART","id":"SM00032","properties":[{"key":"EntryName","value":"CCP"},{"key":"MatchStatus","value":"4"}]},{"database":"SUPFAM","id":"SSF57535","properties":[{"key":"EntryName","value":"Complement control module/SCR domain"},{"key":"MatchStatus","value":"4"}]},{"database":"PROSITE","id":"PS50923","properties":[{"key":"EntryName","value":"SUSHI"},{"key":"MatchStatus","value":"4"}]}],"sequence":{"value":"MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVETGFLHDGLASLELLTSSDSPASASHSAGITGVSHHTHPHITFMMVIF","length":334,"molWeight":37312,"crc64":"7D2C07FACEE70CB4","md5":"91ABC7616DA4F0B242C4E57788AB3710"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":4,"Disulfide bond":1},"uniParcId":"UPI001FC1FB4D"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8S418","uniProtkbId":"A0ACI8S418_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000557117.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00017517"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR037971"}],"value":"Membrane cofactor protein"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000557117.1"}],"value":"CD46"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00025258"}],"value":"Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047055"}],"value":"Interacts with C3b. Interacts with C4b. Interacts with moesin/MSN"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004537"}],"value":"Cytoplasmic vesicle, secretory vesicle, acrosome inner membrane","id":"SL-0004"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004537"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00302"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":34,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":35,"modifier":"EXACT"},"end":{"value":355,"modifier":"EXACT"}},"description":"Membrane cofactor protein","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5051259879"},{"type":"Transmembrane","location":{"start":{"value":307,"modifier":"EXACT"},"end":{"value":329,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":96,"modifier":"EXACT"}},"description":"Sushi","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50923"}]},{"type":"Domain","location":{"start":{"value":97,"modifier":"EXACT"},"end":{"value":159,"modifier":"EXACT"}},"description":"Sushi","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50923"}]},{"type":"Domain","location":{"start":{"value":160,"modifier":"EXACT"},"end":{"value":225,"modifier":"EXACT"}},"description":"Sushi","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50923"}]},{"type":"Domain","location":{"start":{"value":226,"modifier":"EXACT"},"end":{"value":285,"modifier":"EXACT"}},"description":"Sushi","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50923"}]},{"type":"Disulfide bond","location":{"start":{"value":256,"modifier":"EXACT"},"end":{"value":283,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00302"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022875"}],"id":"KW-0180","category":"Biological process","name":"Complement pathway"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023329"}],"id":"KW-0968","category":"Cellular component","name":"Cytoplasmic vesicle"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00302"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023279"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR037971"}],"id":"KW-0278","category":"Biological process","name":"Fertilization"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022859"}],"id":"KW-0391","category":"Biological process","name":"Immunity"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022588"}],"id":"KW-0399","category":"Biological process","name":"Innate immunity"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR037971"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8S418"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8S418"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022659"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00302"}],"id":"KW-0768","category":"Domain","name":"Sushi"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000557117.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000557117.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16710414","citationType":"journal article","authors":["Gregory S.G.","Barlow K.F.","McLay K.E.","Kaul R.","Swarbreck D.","Dunham A.","Scott C.E.","Howe K.L.","Woodfine K.","Spencer C.C.","Jones M.C.","Gillson C.","Searle S.","Zhou Y.","Kokocinski F.","McDonald L.","Evans R.","Phillips K.","Atkinson A.","Cooper R.","Jones C.","Hall R.E.","Andrews T.D.","Lloyd C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Anderson F.","Andrew R.W.","Ashwell R.I.","Aubin K.","Babbage A.K.","Bagguley C.L.","Bailey J.","Beasley H.","Bethel G.","Bird C.P.","Bray-Allen S.","Brown J.Y.","Brown A.J.","Buckley D.","Burton J.","Bye J.","Carder C.","Chapman J.C.","Clark S.Y.","Clarke G.","Clee C.","Cobley V.","Collier R.E.","Corby N.","Coville G.J.","Davies J.","Deadman R.","Dunn M.","Earthrowl M.","Ellington A.G.","Errington H.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Gay L.","Ghori M.R.","Gibson R.","Gilby L.M.","Gillett W.","Glithero R.J.","Grafham D.V.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Hammond S.","Harrison E.S.","Hart E.","Haugen E.","Heath P.D.","Holmes S.","Holt K.","Howden P.J.","Hunt A.R.","Hunt S.E.","Hunter G.","Isherwood J.","James R.","Johnson C.","Johnson D.","Joy A.","Kay M.","Kershaw J.K.","Kibukawa M.","Kimberley A.M.","King A.","Knights A.J.","Lad H.","Laird G.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Loveland J.","Lovell J.","Lush M.J.","Lyne R.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","Matthews N.S.","McLaren S.","Milne S.","Mistry S.","Moore M.J.","Nickerson T.","O'Dell C.N.","Oliver K.","Palmeiri A.","Palmer S.A.","Parker A.","Patel D.","Pearce A.V.","Peck A.I.","Pelan S.","Phelps K.","Phillimore B.J.","Plumb R.","Rajan J.","Raymond C.","Rouse G.","Saenphimmachak C.","Sehra H.K.","Sheridan E.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.","Steward C.","Subramanian S.","Sycamore N.","Tracey A.","Tromans A.","Van Helmond Z.","Wall M.","Wallis J.M.","White S.","Whitehead S.L.","Wilkinson J.E.","Willey D.L.","Williams H.","Wilming L.","Wray P.W.","Wu Z.","Coulson A.","Vaudin M.","Sulston J.E.","Durbin R.","Hubbard T.","Wooster R.","Dunham I.","Carter N.P.","McVean G.","Ross M.T.","Harrow J.","Olson M.V.","Beck S.","Rogers J.","Bentley D.R.","Banerjee R.","Bryant S.P.","Burford D.C.","Burrill W.D.","Clegg S.M.","Dhami P.","Dovey O.","Faulkner L.M.","Gribble S.M.","Langford C.F.","Pandian R.D.","Porter K.M.","Prigmore E."],"citationCrossReferences":[{"database":"PubMed","id":"16710414"},{"database":"DOI","id":"10.1038/nature04727"}],"title":"The DNA sequence and biological annotation of human chromosome 1.","publicationDate":"2006","journal":"Nature","firstPage":"315","lastPage":"321","volume":"441"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000557117.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000557117.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL035209","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL365178","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000887058.1","properties":[{"key":"ProteinId","value":"ENSP00000557117.1"},{"key":"GeneId","value":"ENSG00000117335.22"}]},{"database":"HGNC","id":"HGNC:6953","properties":[{"key":"GeneName","value":"CD46"}]},{"database":"OpenTargets","id":"ENSG00000117335","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000161381","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"CDD","id":"cd00033","properties":[{"key":"EntryName","value":"CCP"},{"key":"MatchStatus","value":"4"}]},{"database":"FunFam","id":"2.10.70.10:FF:000014","properties":[{"key":"EntryName","value":"Membrane cofactor protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.70.10:FF:000042","properties":[{"key":"EntryName","value":"Membrane cofactor protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.70.10:FF:000046","properties":[{"key":"EntryName","value":"Membrane cofactor protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.70.10:FF:000080","properties":[{"key":"EntryName","value":"Membrane cofactor protein"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.10.70.10","properties":[{"key":"EntryName","value":"Complement Module, domain 1"},{"key":"MatchStatus","value":"4"}]},{"database":"InterPro","id":"IPR017341","properties":[{"key":"EntryName","value":"CD46"}]},{"database":"InterPro","id":"IPR051277","properties":[{"key":"EntryName","value":"SEZ6_CSMD_C4BPB_Regulators"}]},{"database":"InterPro","id":"IPR035976","properties":[{"key":"EntryName","value":"Sushi/SCR/CCP_sf"}]},{"database":"InterPro","id":"IPR000436","properties":[{"key":"EntryName","value":"Sushi_SCR_CCP_dom"}]},{"database":"PANTHER","id":"PTHR45656","properties":[{"key":"EntryName","value":"PROTEIN CBR-CLEC-78"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR45656:SF4","properties":[{"key":"EntryName","value":"PROTEIN CBR-CLEC-78"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00084","properties":[{"key":"EntryName","value":"Sushi"},{"key":"MatchStatus","value":"4"}]},{"database":"PIRSF","id":"PIRSF037971","properties":[{"key":"EntryName","value":"TLX_CD46"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00032","properties":[{"key":"EntryName","value":"CCP"},{"key":"MatchStatus","value":"4"}]},{"database":"SUPFAM","id":"SSF57535","properties":[{"key":"EntryName","value":"Complement control module/SCR domain"},{"key":"MatchStatus","value":"4"}]},{"database":"PROSITE","id":"PS50923","properties":[{"key":"EntryName","value":"SUSHI"},{"key":"MatchStatus","value":"4"}]}],"sequence":{"value":"MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKGPRPTYKPPVSNYPGILDSLDVWVIAVIVIAIVVGVAVICVVPYRYLQRRKKKGTYLTDETHREVKFTSL","length":355,"molWeight":40067,"crc64":"4C055231D1812CAF","md5":"86003466BF92B0E1E6F2E1E7506352F6"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Transmembrane":1,"Domain":4,"Disulfide bond":1},"uniParcId":"UPI0040318F41"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8VQX0","uniProtkbId":"A0ACI8VQX0_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000640429.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00017517"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR037971"}],"value":"Membrane cofactor protein"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000640429.1"}],"value":"CD46"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00025258"}],"value":"Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047055"}],"value":"Interacts with C3b. Interacts with C4b. Interacts with moesin/MSN"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004537"}],"value":"Cytoplasmic vesicle, secretory vesicle, acrosome inner membrane","id":"SL-0004"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004537"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00302"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":34,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":35,"modifier":"EXACT"},"end":{"value":355,"modifier":"EXACT"}},"description":"Membrane cofactor protein","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5051366983"},{"type":"Transmembrane","location":{"start":{"value":307,"modifier":"EXACT"},"end":{"value":329,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":96,"modifier":"EXACT"}},"description":"Sushi","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50923"}]},{"type":"Domain","location":{"start":{"value":153,"modifier":"EXACT"},"end":{"value":218,"modifier":"EXACT"}},"description":"Sushi","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50923"}]},{"type":"Domain","location":{"start":{"value":219,"modifier":"EXACT"},"end":{"value":278,"modifier":"EXACT"}},"description":"Sushi","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50923"}]},{"type":"Disulfide bond","location":{"start":{"value":249,"modifier":"EXACT"},"end":{"value":276,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00302"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022875"}],"id":"KW-0180","category":"Biological process","name":"Complement pathway"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023329"}],"id":"KW-0968","category":"Cellular component","name":"Cytoplasmic vesicle"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00302"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023279"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR037971"}],"id":"KW-0278","category":"Biological process","name":"Fertilization"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022859"}],"id":"KW-0391","category":"Biological process","name":"Immunity"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022588"}],"id":"KW-0399","category":"Biological process","name":"Innate immunity"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR037971"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8VQX0"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8VQX0"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022659"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00302"}],"id":"KW-0768","category":"Domain","name":"Sushi"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000640429.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000640429.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16710414","citationType":"journal article","authors":["Gregory S.G.","Barlow K.F.","McLay K.E.","Kaul R.","Swarbreck D.","Dunham A.","Scott C.E.","Howe K.L.","Woodfine K.","Spencer C.C.","Jones M.C.","Gillson C.","Searle S.","Zhou Y.","Kokocinski F.","McDonald L.","Evans R.","Phillips K.","Atkinson A.","Cooper R.","Jones C.","Hall R.E.","Andrews T.D.","Lloyd C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Anderson F.","Andrew R.W.","Ashwell R.I.","Aubin K.","Babbage A.K.","Bagguley C.L.","Bailey J.","Beasley H.","Bethel G.","Bird C.P.","Bray-Allen S.","Brown J.Y.","Brown A.J.","Buckley D.","Burton J.","Bye J.","Carder C.","Chapman J.C.","Clark S.Y.","Clarke G.","Clee C.","Cobley V.","Collier R.E.","Corby N.","Coville G.J.","Davies J.","Deadman R.","Dunn M.","Earthrowl M.","Ellington A.G.","Errington H.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Gay L.","Ghori M.R.","Gibson R.","Gilby L.M.","Gillett W.","Glithero R.J.","Grafham D.V.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Hammond S.","Harrison E.S.","Hart E.","Haugen E.","Heath P.D.","Holmes S.","Holt K.","Howden P.J.","Hunt A.R.","Hunt S.E.","Hunter G.","Isherwood J.","James R.","Johnson C.","Johnson D.","Joy A.","Kay M.","Kershaw J.K.","Kibukawa M.","Kimberley A.M.","King A.","Knights A.J.","Lad H.","Laird G.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Loveland J.","Lovell J.","Lush M.J.","Lyne R.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","Matthews N.S.","McLaren S.","Milne S.","Mistry S.","Moore M.J.","Nickerson T.","O'Dell C.N.","Oliver K.","Palmeiri A.","Palmer S.A.","Parker A.","Patel D.","Pearce A.V.","Peck A.I.","Pelan S.","Phelps K.","Phillimore B.J.","Plumb R.","Rajan J.","Raymond C.","Rouse G.","Saenphimmachak C.","Sehra H.K.","Sheridan E.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.","Steward C.","Subramanian S.","Sycamore N.","Tracey A.","Tromans A.","Van Helmond Z.","Wall M.","Wallis J.M.","White S.","Whitehead S.L.","Wilkinson J.E.","Willey D.L.","Williams H.","Wilming L.","Wray P.W.","Wu Z.","Coulson A.","Vaudin M.","Sulston J.E.","Durbin R.","Hubbard T.","Wooster R.","Dunham I.","Carter N.P.","McVean G.","Ross M.T.","Harrow J.","Olson M.V.","Beck S.","Rogers J.","Bentley D.R.","Banerjee R.","Bryant S.P.","Burford D.C.","Burrill W.D.","Clegg S.M.","Dhami P.","Dovey O.","Faulkner L.M.","Gribble S.M.","Langford C.F.","Pandian R.D.","Porter K.M.","Prigmore E."],"citationCrossReferences":[{"database":"PubMed","id":"16710414"},{"database":"DOI","id":"10.1038/nature04727"}],"title":"The DNA sequence and biological annotation of human chromosome 1.","publicationDate":"2006","journal":"Nature","firstPage":"315","lastPage":"321","volume":"441"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000640429.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000640429.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL035209","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL365178","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000970370.1","properties":[{"key":"ProteinId","value":"ENSP00000640429.1"},{"key":"GeneId","value":"ENSG00000117335.22"}]},{"database":"HGNC","id":"HGNC:6953","properties":[{"key":"GeneName","value":"CD46"}]},{"database":"OpenTargets","id":"ENSG00000117335","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000161381","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"CDD","id":"cd00033","properties":[{"key":"EntryName","value":"CCP"},{"key":"MatchStatus","value":"4"}]},{"database":"FunFam","id":"2.10.70.10:FF:000014","properties":[{"key":"EntryName","value":"Membrane cofactor protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.70.10:FF:000042","properties":[{"key":"EntryName","value":"Membrane cofactor protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.70.10:FF:000046","properties":[{"key":"EntryName","value":"Membrane cofactor protein"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.10.70.10","properties":[{"key":"EntryName","value":"Complement Module, domain 1"},{"key":"MatchStatus","value":"4"}]},{"database":"InterPro","id":"IPR017341","properties":[{"key":"EntryName","value":"CD46"}]},{"database":"InterPro","id":"IPR051277","properties":[{"key":"EntryName","value":"SEZ6_CSMD_C4BPB_Regulators"}]},{"database":"InterPro","id":"IPR035976","properties":[{"key":"EntryName","value":"Sushi/SCR/CCP_sf"}]},{"database":"InterPro","id":"IPR000436","properties":[{"key":"EntryName","value":"Sushi_SCR_CCP_dom"}]},{"database":"PANTHER","id":"PTHR45656","properties":[{"key":"EntryName","value":"PROTEIN CBR-CLEC-78"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR45656:SF4","properties":[{"key":"EntryName","value":"PROTEIN CBR-CLEC-78"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00084","properties":[{"key":"EntryName","value":"Sushi"},{"key":"MatchStatus","value":"4"}]},{"database":"PIRSF","id":"PIRSF037971","properties":[{"key":"EntryName","value":"TLX_CD46"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00032","properties":[{"key":"EntryName","value":"CCP"},{"key":"MatchStatus","value":"4"}]},{"database":"SUPFAM","id":"SSF57535","properties":[{"key":"EntryName","value":"Complement control module/SCR domain"},{"key":"MatchStatus","value":"4"}]},{"database":"PROSITE","id":"PS50923","properties":[{"key":"EntryName","value":"SUSHI"},{"key":"MatchStatus","value":"3"}]}],"sequence":{"value":"MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSEVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKGPRPTYKPPVSNYPGYPKPEEGILDSLDVWVIAVIVIAIVVGVAVICVVPYRYLQRRKKKGTYLTDETHREVKFTSL","length":355,"molWeight":40144,"crc64":"C130C2C7CD198916","md5":"72321D4BBDF4087A7B970D517D5FEC68"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Transmembrane":1,"Domain":3,"Disulfide bond":1},"uniParcId":"UPI004031C209"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A8Q3WKR0","uniProtkbId":"A0A8Q3WKR0_HUMAN","entryAudit":{"firstPublicDate":"2022-10-12","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2022-10-12","entryVersion":20,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000512168.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00017517"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR037971"}],"value":"Membrane cofactor protein"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000512168.1"}],"value":"CD46"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00025258"}],"value":"Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047055"}],"value":"Interacts with C3b. Interacts with C4b. Interacts with moesin/MSN"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004537"}],"value":"Cytoplasmic vesicle, secretory vesicle, acrosome inner membrane","id":"SL-0004"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004537"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00302"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":34,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":35,"modifier":"EXACT"},"end":{"value":336,"modifier":"EXACT"}},"description":"Membrane cofactor protein","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5035827918"},{"type":"Domain","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":96,"modifier":"EXACT"}},"description":"Sushi","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50923"}]},{"type":"Domain","location":{"start":{"value":97,"modifier":"EXACT"},"end":{"value":159,"modifier":"EXACT"}},"description":"Sushi","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50923"}]},{"type":"Domain","location":{"start":{"value":160,"modifier":"EXACT"},"end":{"value":225,"modifier":"EXACT"}},"description":"Sushi","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50923"}]},{"type":"Domain","location":{"start":{"value":226,"modifier":"EXACT"},"end":{"value":285,"modifier":"EXACT"}},"description":"Sushi","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50923"}]},{"type":"Disulfide bond","location":{"start":{"value":256,"modifier":"EXACT"},"end":{"value":283,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00302"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022875"}],"id":"KW-0180","category":"Biological process","name":"Complement pathway"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023329"}],"id":"KW-0968","category":"Cellular component","name":"Cytoplasmic vesicle"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00302"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023279"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR037971"}],"id":"KW-0278","category":"Biological process","name":"Fertilization"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022859"}],"id":"KW-0391","category":"Biological process","name":"Immunity"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022588"}],"id":"KW-0399","category":"Biological process","name":"Innate immunity"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR037971"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0A8Q3WKR0"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0A8Q3WKR0"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022659"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00302"}],"id":"KW-0768","category":"Domain","name":"Sushi"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000512168.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000512168.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16710414","citationType":"journal article","authors":["Gregory S.G.","Barlow K.F.","McLay K.E.","Kaul R.","Swarbreck D.","Dunham A.","Scott C.E.","Howe K.L.","Woodfine K.","Spencer C.C.","Jones M.C.","Gillson C.","Searle S.","Zhou Y.","Kokocinski F.","McDonald L.","Evans R.","Phillips K.","Atkinson A.","Cooper R.","Jones C.","Hall R.E.","Andrews T.D.","Lloyd C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Anderson F.","Andrew R.W.","Ashwell R.I.","Aubin K.","Babbage A.K.","Bagguley C.L.","Bailey J.","Beasley H.","Bethel G.","Bird C.P.","Bray-Allen S.","Brown J.Y.","Brown A.J.","Buckley D.","Burton J.","Bye J.","Carder C.","Chapman J.C.","Clark S.Y.","Clarke G.","Clee C.","Cobley V.","Collier R.E.","Corby N.","Coville G.J.","Davies J.","Deadman R.","Dunn M.","Earthrowl M.","Ellington A.G.","Errington H.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Gay L.","Ghori M.R.","Gibson R.","Gilby L.M.","Gillett W.","Glithero R.J.","Grafham D.V.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Hammond S.","Harrison E.S.","Hart E.","Haugen E.","Heath P.D.","Holmes S.","Holt K.","Howden P.J.","Hunt A.R.","Hunt S.E.","Hunter G.","Isherwood J.","James R.","Johnson C.","Johnson D.","Joy A.","Kay M.","Kershaw J.K.","Kibukawa M.","Kimberley A.M.","King A.","Knights A.J.","Lad H.","Laird G.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Loveland J.","Lovell J.","Lush M.J.","Lyne R.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","Matthews N.S.","McLaren S.","Milne S.","Mistry S.","Moore M.J.","Nickerson T.","O'Dell C.N.","Oliver K.","Palmeiri A.","Palmer S.A.","Parker A.","Patel D.","Pearce A.V.","Peck A.I.","Pelan S.","Phelps K.","Phillimore B.J.","Plumb R.","Rajan J.","Raymond C.","Rouse G.","Saenphimmachak C.","Sehra H.K.","Sheridan E.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.","Steward C.","Subramanian S.","Sycamore N.","Tracey A.","Tromans A.","Van Helmond Z.","Wall M.","Wallis J.M.","White S.","Whitehead S.L.","Wilkinson J.E.","Willey D.L.","Williams H.","Wilming L.","Wray P.W.","Wu Z.","Coulson A.","Vaudin M.","Sulston J.E.","Durbin R.","Hubbard T.","Wooster R.","Dunham I.","Carter N.P.","McVean G.","Ross M.T.","Harrow J.","Olson M.V.","Beck S.","Rogers J.","Bentley D.R.","Banerjee R.","Bryant S.P.","Burford D.C.","Burrill W.D.","Clegg S.M.","Dhami P.","Dovey O.","Faulkner L.M.","Gribble S.M.","Langford C.F.","Pandian R.D.","Porter K.M.","Prigmore E."],"citationCrossReferences":[{"database":"PubMed","id":"16710414"},{"database":"DOI","id":"10.1038/nature04727"}],"title":"The DNA sequence and biological annotation of human chromosome 1.","publicationDate":"2006","journal":"Nature","firstPage":"315","lastPage":"321","volume":"441"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000512168.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000512168.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL035209","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL365178","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A8Q3WKR0","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0A8Q3WKR0","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000695778.1","properties":[{"key":"ProteinId","value":"ENSP00000512168.1"},{"key":"GeneId","value":"ENSG00000117335.22"}]},{"database":"HGNC","id":"HGNC:6953","properties":[{"key":"GeneName","value":"CD46"}]},{"database":"GeneTree","id":"ENSGT00940000161381","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"6480633at2759","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"ExpressionAtlas","id":"A0A8Q3WKR0","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0009986","properties":[{"key":"GoTerm","value":"C:cell surface"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0002079","properties":[{"key":"GoTerm","value":"C:inner acrosomal membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0050776","properties":[{"key":"GoTerm","value":"P:regulation of immune response"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0007338","properties":[{"key":"GoTerm","value":"P:single fertilization"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"CDD","id":"cd00033","properties":[{"key":"EntryName","value":"CCP"},{"key":"MatchStatus","value":"4"}]},{"database":"FunFam","id":"2.10.70.10:FF:000014","properties":[{"key":"EntryName","value":"Membrane cofactor protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.70.10:FF:000042","properties":[{"key":"EntryName","value":"Membrane cofactor protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.70.10:FF:000046","properties":[{"key":"EntryName","value":"Membrane cofactor protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.70.10:FF:000080","properties":[{"key":"EntryName","value":"Membrane cofactor protein"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.10.70.10","properties":[{"key":"EntryName","value":"Complement Module, domain 1"},{"key":"MatchStatus","value":"4"}]},{"database":"InterPro","id":"IPR017341","properties":[{"key":"EntryName","value":"CD46"}]},{"database":"InterPro","id":"IPR051277","properties":[{"key":"EntryName","value":"SEZ6_CSMD_C4BPB_Regulators"}]},{"database":"InterPro","id":"IPR035976","properties":[{"key":"EntryName","value":"Sushi/SCR/CCP_sf"}]},{"database":"InterPro","id":"IPR000436","properties":[{"key":"EntryName","value":"Sushi_SCR_CCP_dom"}]},{"database":"PANTHER","id":"PTHR45656","properties":[{"key":"EntryName","value":"PROTEIN CBR-CLEC-78"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR45656:SF4","properties":[{"key":"EntryName","value":"PROTEIN CBR-CLEC-78"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00084","properties":[{"key":"EntryName","value":"Sushi"},{"key":"MatchStatus","value":"4"}]},{"database":"PIRSF","id":"PIRSF037971","properties":[{"key":"EntryName","value":"TLX_CD46"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00032","properties":[{"key":"EntryName","value":"CCP"},{"key":"MatchStatus","value":"4"}]},{"database":"SUPFAM","id":"SSF57535","properties":[{"key":"EntryName","value":"Complement control module/SCR domain"},{"key":"MatchStatus","value":"4"}]},{"database":"PROSITE","id":"PS50923","properties":[{"key":"EntryName","value":"SUSHI"},{"key":"MatchStatus","value":"4"}]}],"sequence":{"value":"MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKGPRPTYKPPVSNYPGYPKPEEGILDSLDVWVIAVIVIAIDIFKGGRRKAHT","length":336,"molWeight":37799,"crc64":"F0B7875D6A614C45","md5":"D26A5930A7A7E66D5D4A33770DED5706"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":4,"Disulfide bond":1},"uniParcId":"UPI001FC21117"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A8Q3WKR4","uniProtkbId":"A0A8Q3WKR4_HUMAN","entryAudit":{"firstPublicDate":"2022-10-12","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2022-10-12","entryVersion":20,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000512170.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00017517"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR037971"}],"value":"Membrane cofactor protein"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000512170.1"}],"value":"CD46"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00025258"}],"value":"Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047055"}],"value":"Interacts with C3b. Interacts with C4b. Interacts with moesin/MSN"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004537"}],"value":"Cytoplasmic vesicle, secretory vesicle, acrosome inner membrane","id":"SL-0004"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004537"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00302"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":34,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":35,"modifier":"EXACT"},"end":{"value":335,"modifier":"EXACT"}},"description":"Membrane cofactor protein","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5035933940"},{"type":"Domain","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":96,"modifier":"EXACT"}},"description":"Sushi","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50923"}]},{"type":"Domain","location":{"start":{"value":97,"modifier":"EXACT"},"end":{"value":159,"modifier":"EXACT"}},"description":"Sushi","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50923"}]},{"type":"Domain","location":{"start":{"value":160,"modifier":"EXACT"},"end":{"value":225,"modifier":"EXACT"}},"description":"Sushi","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50923"}]},{"type":"Domain","location":{"start":{"value":226,"modifier":"EXACT"},"end":{"value":285,"modifier":"EXACT"}},"description":"Sushi","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50923"}]},{"type":"Disulfide bond","location":{"start":{"value":256,"modifier":"EXACT"},"end":{"value":283,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00302"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022875"}],"id":"KW-0180","category":"Biological process","name":"Complement pathway"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023329"}],"id":"KW-0968","category":"Cellular component","name":"Cytoplasmic vesicle"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00302"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023279"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR037971"}],"id":"KW-0278","category":"Biological process","name":"Fertilization"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022859"}],"id":"KW-0391","category":"Biological process","name":"Immunity"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022588"}],"id":"KW-0399","category":"Biological process","name":"Innate immunity"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR037971"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0A8Q3WKR4"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0A8Q3WKR4"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022659"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00302"}],"id":"KW-0768","category":"Domain","name":"Sushi"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000512170.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000512170.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16710414","citationType":"journal article","authors":["Gregory S.G.","Barlow K.F.","McLay K.E.","Kaul R.","Swarbreck D.","Dunham A.","Scott C.E.","Howe K.L.","Woodfine K.","Spencer C.C.","Jones M.C.","Gillson C.","Searle S.","Zhou Y.","Kokocinski F.","McDonald L.","Evans R.","Phillips K.","Atkinson A.","Cooper R.","Jones C.","Hall R.E.","Andrews T.D.","Lloyd C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Anderson F.","Andrew R.W.","Ashwell R.I.","Aubin K.","Babbage A.K.","Bagguley C.L.","Bailey J.","Beasley H.","Bethel G.","Bird C.P.","Bray-Allen S.","Brown J.Y.","Brown A.J.","Buckley D.","Burton J.","Bye J.","Carder C.","Chapman J.C.","Clark S.Y.","Clarke G.","Clee C.","Cobley V.","Collier R.E.","Corby N.","Coville G.J.","Davies J.","Deadman R.","Dunn M.","Earthrowl M.","Ellington A.G.","Errington H.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Gay L.","Ghori M.R.","Gibson R.","Gilby L.M.","Gillett W.","Glithero R.J.","Grafham D.V.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Hammond S.","Harrison E.S.","Hart E.","Haugen E.","Heath P.D.","Holmes S.","Holt K.","Howden P.J.","Hunt A.R.","Hunt S.E.","Hunter G.","Isherwood J.","James R.","Johnson C.","Johnson D.","Joy A.","Kay M.","Kershaw J.K.","Kibukawa M.","Kimberley A.M.","King A.","Knights A.J.","Lad H.","Laird G.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Loveland J.","Lovell J.","Lush M.J.","Lyne R.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","Matthews N.S.","McLaren S.","Milne S.","Mistry S.","Moore M.J.","Nickerson T.","O'Dell C.N.","Oliver K.","Palmeiri A.","Palmer S.A.","Parker A.","Patel D.","Pearce A.V.","Peck A.I.","Pelan S.","Phelps K.","Phillimore B.J.","Plumb R.","Rajan J.","Raymond C.","Rouse G.","Saenphimmachak C.","Sehra H.K.","Sheridan E.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.","Steward C.","Subramanian S.","Sycamore N.","Tracey A.","Tromans A.","Van Helmond Z.","Wall M.","Wallis J.M.","White S.","Whitehead S.L.","Wilkinson J.E.","Willey D.L.","Williams H.","Wilming L.","Wray P.W.","Wu Z.","Coulson A.","Vaudin M.","Sulston J.E.","Durbin R.","Hubbard T.","Wooster R.","Dunham I.","Carter N.P.","McVean G.","Ross M.T.","Harrow J.","Olson M.V.","Beck S.","Rogers J.","Bentley D.R.","Banerjee R.","Bryant S.P.","Burford D.C.","Burrill W.D.","Clegg S.M.","Dhami P.","Dovey O.","Faulkner L.M.","Gribble S.M.","Langford C.F.","Pandian R.D.","Porter K.M.","Prigmore E."],"citationCrossReferences":[{"database":"PubMed","id":"16710414"},{"database":"DOI","id":"10.1038/nature04727"}],"title":"The DNA sequence and biological annotation of human chromosome 1.","publicationDate":"2006","journal":"Nature","firstPage":"315","lastPage":"321","volume":"441"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000512170.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000512170.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL035209","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL365178","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A8Q3WKR4","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0A8Q3WKR4","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000695781.1","properties":[{"key":"ProteinId","value":"ENSP00000512170.1"},{"key":"GeneId","value":"ENSG00000117335.22"}]},{"database":"HGNC","id":"HGNC:6953","properties":[{"key":"GeneName","value":"CD46"}]},{"database":"GeneTree","id":"ENSGT00940000161381","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"6480633at2759","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"ExpressionAtlas","id":"A0A8Q3WKR4","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0009986","properties":[{"key":"GoTerm","value":"C:cell surface"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0002079","properties":[{"key":"GoTerm","value":"C:inner acrosomal membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0050776","properties":[{"key":"GoTerm","value":"P:regulation of immune response"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0007338","properties":[{"key":"GoTerm","value":"P:single fertilization"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"CDD","id":"cd00033","properties":[{"key":"EntryName","value":"CCP"},{"key":"MatchStatus","value":"4"}]},{"database":"FunFam","id":"2.10.70.10:FF:000014","properties":[{"key":"EntryName","value":"Membrane cofactor protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.70.10:FF:000042","properties":[{"key":"EntryName","value":"Membrane cofactor protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.70.10:FF:000046","properties":[{"key":"EntryName","value":"Membrane cofactor protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.70.10:FF:000080","properties":[{"key":"EntryName","value":"Membrane cofactor protein"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.10.70.10","properties":[{"key":"EntryName","value":"Complement Module, domain 1"},{"key":"MatchStatus","value":"4"}]},{"database":"InterPro","id":"IPR017341","properties":[{"key":"EntryName","value":"CD46"}]},{"database":"InterPro","id":"IPR051277","properties":[{"key":"EntryName","value":"SEZ6_CSMD_C4BPB_Regulators"}]},{"database":"InterPro","id":"IPR035976","properties":[{"key":"EntryName","value":"Sushi/SCR/CCP_sf"}]},{"database":"InterPro","id":"IPR000436","properties":[{"key":"EntryName","value":"Sushi_SCR_CCP_dom"}]},{"database":"PANTHER","id":"PTHR45656","properties":[{"key":"EntryName","value":"PROTEIN CBR-CLEC-78"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR45656:SF4","properties":[{"key":"EntryName","value":"PROTEIN CBR-CLEC-78"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00084","properties":[{"key":"EntryName","value":"Sushi"},{"key":"MatchStatus","value":"4"}]},{"database":"PIRSF","id":"PIRSF037971","properties":[{"key":"EntryName","value":"TLX_CD46"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00032","properties":[{"key":"EntryName","value":"CCP"},{"key":"MatchStatus","value":"4"}]},{"database":"SUPFAM","id":"SSF57535","properties":[{"key":"EntryName","value":"Complement control module/SCR domain"},{"key":"MatchStatus","value":"4"}]},{"database":"PROSITE","id":"PS50923","properties":[{"key":"EntryName","value":"SUSHI"},{"key":"MatchStatus","value":"4"}]}],"sequence":{"value":"MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKGPRPTYKPPVSNYPVRPLSCRCVGVCWRSTPDPVFLSITSRGCRTTNIAA","length":335,"molWeight":37645,"crc64":"09443FA040D2DBA8","md5":"9297F5BA63C3923A0C9DC0DA5F3D2204"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":4,"Disulfide bond":1},"uniParcId":"UPI001FC1FCC5"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A8Q3WKW1","uniProtkbId":"A0A8Q3WKW1_HUMAN","entryAudit":{"firstPublicDate":"2022-10-12","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2022-10-12","entryVersion":20,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000512169.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00017517"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR037971"}],"value":"Membrane cofactor protein"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000512169.1"}],"value":"CD46"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00025258"}],"value":"Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047055"}],"value":"Interacts with C3b. Interacts with C4b. Interacts with moesin/MSN"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004537"}],"value":"Cytoplasmic vesicle, secretory vesicle, acrosome inner membrane","id":"SL-0004"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004537"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00302"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":34,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":35,"modifier":"EXACT"},"end":{"value":346,"modifier":"EXACT"}},"description":"Membrane cofactor protein","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5035712551"},{"type":"Domain","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":96,"modifier":"EXACT"}},"description":"Sushi","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50923"}]},{"type":"Domain","location":{"start":{"value":97,"modifier":"EXACT"},"end":{"value":159,"modifier":"EXACT"}},"description":"Sushi","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50923"}]},{"type":"Domain","location":{"start":{"value":160,"modifier":"EXACT"},"end":{"value":225,"modifier":"EXACT"}},"description":"Sushi","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50923"}]},{"type":"Domain","location":{"start":{"value":226,"modifier":"EXACT"},"end":{"value":285,"modifier":"EXACT"}},"description":"Sushi","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50923"}]},{"type":"Disulfide bond","location":{"start":{"value":256,"modifier":"EXACT"},"end":{"value":283,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00302"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022875"}],"id":"KW-0180","category":"Biological process","name":"Complement pathway"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023329"}],"id":"KW-0968","category":"Cellular component","name":"Cytoplasmic vesicle"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00302"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023279"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR037971"}],"id":"KW-0278","category":"Biological process","name":"Fertilization"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022859"}],"id":"KW-0391","category":"Biological process","name":"Immunity"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022588"}],"id":"KW-0399","category":"Biological process","name":"Innate immunity"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR037971"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0A8Q3WKW1"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0A8Q3WKW1"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022659"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00302"}],"id":"KW-0768","category":"Domain","name":"Sushi"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000512169.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000512169.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16710414","citationType":"journal article","authors":["Gregory S.G.","Barlow K.F.","McLay K.E.","Kaul R.","Swarbreck D.","Dunham A.","Scott C.E.","Howe K.L.","Woodfine K.","Spencer C.C.","Jones M.C.","Gillson C.","Searle S.","Zhou Y.","Kokocinski F.","McDonald L.","Evans R.","Phillips K.","Atkinson A.","Cooper R.","Jones C.","Hall R.E.","Andrews T.D.","Lloyd C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Anderson F.","Andrew R.W.","Ashwell R.I.","Aubin K.","Babbage A.K.","Bagguley C.L.","Bailey J.","Beasley H.","Bethel G.","Bird C.P.","Bray-Allen S.","Brown J.Y.","Brown A.J.","Buckley D.","Burton J.","Bye J.","Carder C.","Chapman J.C.","Clark S.Y.","Clarke G.","Clee C.","Cobley V.","Collier R.E.","Corby N.","Coville G.J.","Davies J.","Deadman R.","Dunn M.","Earthrowl M.","Ellington A.G.","Errington H.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Gay L.","Ghori M.R.","Gibson R.","Gilby L.M.","Gillett W.","Glithero R.J.","Grafham D.V.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Hammond S.","Harrison E.S.","Hart E.","Haugen E.","Heath P.D.","Holmes S.","Holt K.","Howden P.J.","Hunt A.R.","Hunt S.E.","Hunter G.","Isherwood J.","James R.","Johnson C.","Johnson D.","Joy A.","Kay M.","Kershaw J.K.","Kibukawa M.","Kimberley A.M.","King A.","Knights A.J.","Lad H.","Laird G.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Loveland J.","Lovell J.","Lush M.J.","Lyne R.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","Matthews N.S.","McLaren S.","Milne S.","Mistry S.","Moore M.J.","Nickerson T.","O'Dell C.N.","Oliver K.","Palmeiri A.","Palmer S.A.","Parker A.","Patel D.","Pearce A.V.","Peck A.I.","Pelan S.","Phelps K.","Phillimore B.J.","Plumb R.","Rajan J.","Raymond C.","Rouse G.","Saenphimmachak C.","Sehra H.K.","Sheridan E.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.","Steward C.","Subramanian S.","Sycamore N.","Tracey A.","Tromans A.","Van Helmond Z.","Wall M.","Wallis J.M.","White S.","Whitehead S.L.","Wilkinson J.E.","Willey D.L.","Williams H.","Wilming L.","Wray P.W.","Wu Z.","Coulson A.","Vaudin M.","Sulston J.E.","Durbin R.","Hubbard T.","Wooster R.","Dunham I.","Carter N.P.","McVean G.","Ross M.T.","Harrow J.","Olson M.V.","Beck S.","Rogers J.","Bentley D.R.","Banerjee R.","Bryant S.P.","Burford D.C.","Burrill W.D.","Clegg S.M.","Dhami P.","Dovey O.","Faulkner L.M.","Gribble S.M.","Langford C.F.","Pandian R.D.","Porter K.M.","Prigmore E."],"citationCrossReferences":[{"database":"PubMed","id":"16710414"},{"database":"DOI","id":"10.1038/nature04727"}],"title":"The DNA sequence and biological annotation of human chromosome 1.","publicationDate":"2006","journal":"Nature","firstPage":"315","lastPage":"321","volume":"441"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000512169.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000512169.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL035209","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL365178","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A8Q3WKW1","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0A8Q3WKW1","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000695780.1","properties":[{"key":"ProteinId","value":"ENSP00000512169.1"},{"key":"GeneId","value":"ENSG00000117335.22"}]},{"database":"HGNC","id":"HGNC:6953","properties":[{"key":"GeneName","value":"CD46"}]},{"database":"GeneTree","id":"ENSGT00940000161381","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"6480633at2759","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"ExpressionAtlas","id":"A0A8Q3WKW1","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0009986","properties":[{"key":"GoTerm","value":"C:cell surface"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0002079","properties":[{"key":"GoTerm","value":"C:inner acrosomal membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0050776","properties":[{"key":"GoTerm","value":"P:regulation of immune response"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0007338","properties":[{"key":"GoTerm","value":"P:single fertilization"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"CDD","id":"cd00033","properties":[{"key":"EntryName","value":"CCP"},{"key":"MatchStatus","value":"4"}]},{"database":"FunFam","id":"2.10.70.10:FF:000014","properties":[{"key":"EntryName","value":"Membrane cofactor protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.70.10:FF:000042","properties":[{"key":"EntryName","value":"Membrane cofactor protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.70.10:FF:000046","properties":[{"key":"EntryName","value":"Membrane cofactor protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.70.10:FF:000080","properties":[{"key":"EntryName","value":"Membrane cofactor protein"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.10.70.10","properties":[{"key":"EntryName","value":"Complement Module, domain 1"},{"key":"MatchStatus","value":"4"}]},{"database":"InterPro","id":"IPR017341","properties":[{"key":"EntryName","value":"CD46"}]},{"database":"InterPro","id":"IPR050350","properties":[{"key":"EntryName","value":"Compl-Cell_Adhes-Reg"}]},{"database":"InterPro","id":"IPR035976","properties":[{"key":"EntryName","value":"Sushi/SCR/CCP_sf"}]},{"database":"InterPro","id":"IPR000436","properties":[{"key":"EntryName","value":"Sushi_SCR_CCP_dom"}]},{"database":"PANTHER","id":"PTHR19325","properties":[{"key":"EntryName","value":"COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR19325:SF521","properties":[{"key":"EntryName","value":"MEMBRANE COFACTOR PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00084","properties":[{"key":"EntryName","value":"Sushi"},{"key":"MatchStatus","value":"4"}]},{"database":"PIRSF","id":"PIRSF037971","properties":[{"key":"EntryName","value":"TLX_CD46"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00032","properties":[{"key":"EntryName","value":"CCP"},{"key":"MatchStatus","value":"4"}]},{"database":"SUPFAM","id":"SSF57535","properties":[{"key":"EntryName","value":"Complement control module/SCR domain"},{"key":"MatchStatus","value":"4"}]},{"database":"PROSITE","id":"PS50923","properties":[{"key":"EntryName","value":"SUSHI"},{"key":"MatchStatus","value":"4"}]}],"sequence":{"value":"MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKGPRPTYKPPVSNYPGYPKPEEGILDSLDIFKGGRRKGKQMVELNMPLTRLNQPLQQSREAE","length":346,"molWeight":39091,"crc64":"034DD1181C958136","md5":"234680A686AC78EE64CD4359860F5389"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":4,"Disulfide bond":1},"uniParcId":"UPI001FC204B4"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8SQV1","uniProtkbId":"A0ACI8SQV1_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000585266.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00017517"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR037971"}],"value":"Membrane cofactor protein"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000585266.1"}],"value":"CD46"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00025258"}],"value":"Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047055"}],"value":"Interacts with C3b. Interacts with C4b. Interacts with moesin/MSN"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004537"}],"value":"Cytoplasmic vesicle, secretory vesicle, acrosome inner membrane","id":"SL-0004"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004537"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00302"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":34,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":35,"modifier":"EXACT"},"end":{"value":353,"modifier":"EXACT"}},"description":"Membrane cofactor protein","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5051546028"},{"type":"Transmembrane","location":{"start":{"value":305,"modifier":"EXACT"},"end":{"value":327,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":96,"modifier":"EXACT"}},"description":"Sushi","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50923"}]},{"type":"Domain","location":{"start":{"value":97,"modifier":"EXACT"},"end":{"value":159,"modifier":"EXACT"}},"description":"Sushi","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50923"}]},{"type":"Domain","location":{"start":{"value":187,"modifier":"EXACT"},"end":{"value":246,"modifier":"EXACT"}},"description":"Sushi","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50923"}]},{"type":"Region","location":{"start":{"value":252,"modifier":"EXACT"},"end":{"value":289,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":252,"modifier":"EXACT"},"end":{"value":276,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Disulfide bond","location":{"start":{"value":217,"modifier":"EXACT"},"end":{"value":244,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00302"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022875"}],"id":"KW-0180","category":"Biological process","name":"Complement pathway"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023329"}],"id":"KW-0968","category":"Cellular component","name":"Cytoplasmic vesicle"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00302"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023279"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR037971"}],"id":"KW-0278","category":"Biological process","name":"Fertilization"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022859"}],"id":"KW-0391","category":"Biological process","name":"Immunity"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022588"}],"id":"KW-0399","category":"Biological process","name":"Innate immunity"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR037971"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8SQV1"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8SQV1"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022659"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00302"}],"id":"KW-0768","category":"Domain","name":"Sushi"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000585266.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000585266.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16710414","citationType":"journal article","authors":["Gregory S.G.","Barlow K.F.","McLay K.E.","Kaul R.","Swarbreck D.","Dunham A.","Scott C.E.","Howe K.L.","Woodfine K.","Spencer C.C.","Jones M.C.","Gillson C.","Searle S.","Zhou Y.","Kokocinski F.","McDonald L.","Evans R.","Phillips K.","Atkinson A.","Cooper R.","Jones C.","Hall R.E.","Andrews T.D.","Lloyd C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Anderson F.","Andrew R.W.","Ashwell R.I.","Aubin K.","Babbage A.K.","Bagguley C.L.","Bailey J.","Beasley H.","Bethel G.","Bird C.P.","Bray-Allen S.","Brown J.Y.","Brown A.J.","Buckley D.","Burton J.","Bye J.","Carder C.","Chapman J.C.","Clark S.Y.","Clarke G.","Clee C.","Cobley V.","Collier R.E.","Corby N.","Coville G.J.","Davies J.","Deadman R.","Dunn M.","Earthrowl M.","Ellington A.G.","Errington H.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Gay L.","Ghori M.R.","Gibson R.","Gilby L.M.","Gillett W.","Glithero R.J.","Grafham D.V.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Hammond S.","Harrison E.S.","Hart E.","Haugen E.","Heath P.D.","Holmes S.","Holt K.","Howden P.J.","Hunt A.R.","Hunt S.E.","Hunter G.","Isherwood J.","James R.","Johnson C.","Johnson D.","Joy A.","Kay M.","Kershaw J.K.","Kibukawa M.","Kimberley A.M.","King A.","Knights A.J.","Lad H.","Laird G.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Loveland J.","Lovell J.","Lush M.J.","Lyne R.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","Matthews N.S.","McLaren S.","Milne S.","Mistry S.","Moore M.J.","Nickerson T.","O'Dell C.N.","Oliver K.","Palmeiri A.","Palmer S.A.","Parker A.","Patel D.","Pearce A.V.","Peck A.I.","Pelan S.","Phelps K.","Phillimore B.J.","Plumb R.","Rajan J.","Raymond C.","Rouse G.","Saenphimmachak C.","Sehra H.K.","Sheridan E.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.","Steward C.","Subramanian S.","Sycamore N.","Tracey A.","Tromans A.","Van Helmond Z.","Wall M.","Wallis J.M.","White S.","Whitehead S.L.","Wilkinson J.E.","Willey D.L.","Williams H.","Wilming L.","Wray P.W.","Wu Z.","Coulson A.","Vaudin M.","Sulston J.E.","Durbin R.","Hubbard T.","Wooster R.","Dunham I.","Carter N.P.","McVean G.","Ross M.T.","Harrow J.","Olson M.V.","Beck S.","Rogers J.","Bentley D.R.","Banerjee R.","Bryant S.P.","Burford D.C.","Burrill W.D.","Clegg S.M.","Dhami P.","Dovey O.","Faulkner L.M.","Gribble S.M.","Langford C.F.","Pandian R.D.","Porter K.M.","Prigmore E."],"citationCrossReferences":[{"database":"PubMed","id":"16710414"},{"database":"DOI","id":"10.1038/nature04727"}],"title":"The DNA sequence and biological annotation of human chromosome 1.","publicationDate":"2006","journal":"Nature","firstPage":"315","lastPage":"321","volume":"441"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000585266.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000585266.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL035209","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL365178","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000915207.1","properties":[{"key":"ProteinId","value":"ENSP00000585266.1"},{"key":"GeneId","value":"ENSG00000117335.22"}]},{"database":"HGNC","id":"HGNC:6953","properties":[{"key":"GeneName","value":"CD46"}]},{"database":"OpenTargets","id":"ENSG00000117335","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000161381","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"CDD","id":"cd00033","properties":[{"key":"EntryName","value":"CCP"},{"key":"MatchStatus","value":"3"}]},{"database":"FunFam","id":"2.10.70.10:FF:000014","properties":[{"key":"EntryName","value":"Membrane cofactor protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.70.10:FF:000046","properties":[{"key":"EntryName","value":"Membrane cofactor protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.70.10:FF:000080","properties":[{"key":"EntryName","value":"Membrane cofactor protein"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.10.70.10","properties":[{"key":"EntryName","value":"Complement Module, domain 1"},{"key":"MatchStatus","value":"4"}]},{"database":"InterPro","id":"IPR017341","properties":[{"key":"EntryName","value":"CD46"}]},{"database":"InterPro","id":"IPR051277","properties":[{"key":"EntryName","value":"SEZ6_CSMD_C4BPB_Regulators"}]},{"database":"InterPro","id":"IPR035976","properties":[{"key":"EntryName","value":"Sushi/SCR/CCP_sf"}]},{"database":"InterPro","id":"IPR000436","properties":[{"key":"EntryName","value":"Sushi_SCR_CCP_dom"}]},{"database":"PANTHER","id":"PTHR45656","properties":[{"key":"EntryName","value":"PROTEIN CBR-CLEC-78"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR45656:SF4","properties":[{"key":"EntryName","value":"PROTEIN CBR-CLEC-78"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00084","properties":[{"key":"EntryName","value":"Sushi"},{"key":"MatchStatus","value":"3"}]},{"database":"PIRSF","id":"PIRSF037971","properties":[{"key":"EntryName","value":"TLX_CD46"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00032","properties":[{"key":"EntryName","value":"CCP"},{"key":"MatchStatus","value":"3"}]},{"database":"SUPFAM","id":"SSF57535","properties":[{"key":"EntryName","value":"Complement control module/SCR domain"},{"key":"MatchStatus","value":"4"}]},{"database":"PROSITE","id":"PS50923","properties":[{"key":"EntryName","value":"SUSHI"},{"key":"MatchStatus","value":"3"}]}],"sequence":{"value":"MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICENPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSSTKPPALSHSVSTSSTTKSPASSASGPRPTYKPPVSNYPGYPKPEEGILDSLDVWVIAVIVIAIVVGVAVICVVPYRYLQRRKKKGTYLTDETHREVKFTSL","length":353,"molWeight":39485,"crc64":"6895B7F56ADA1748","md5":"384C409BA2AC97C45545CE8464C7D729"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Transmembrane":1,"Domain":3,"Region":1,"Compositional bias":1,"Disulfide bond":1},"uniParcId":"UPI0040317B07"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8VRC2","uniProtkbId":"A0ACI8VRC2_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000640432.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00017517"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR037971"}],"value":"Membrane cofactor protein"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000640432.1"}],"value":"CD46"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00025258"}],"value":"Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047055"}],"value":"Interacts with C3b. Interacts with C4b. Interacts with moesin/MSN"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004537"}],"value":"Cytoplasmic vesicle, secretory vesicle, acrosome inner membrane","id":"SL-0004"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004537"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00302"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":34,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":35,"modifier":"EXACT"},"end":{"value":335,"modifier":"EXACT"}},"description":"Membrane cofactor protein","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5051324516"},{"type":"Transmembrane","location":{"start":{"value":287,"modifier":"EXACT"},"end":{"value":309,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":96,"modifier":"EXACT"}},"description":"Sushi","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50923"}]},{"type":"Domain","location":{"start":{"value":97,"modifier":"EXACT"},"end":{"value":159,"modifier":"EXACT"}},"description":"Sushi","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50923"}]},{"type":"Domain","location":{"start":{"value":160,"modifier":"EXACT"},"end":{"value":225,"modifier":"EXACT"}},"description":"Sushi","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50923"}]},{"type":"Domain","location":{"start":{"value":226,"modifier":"EXACT"},"end":{"value":285,"modifier":"EXACT"}},"description":"Sushi","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50923"}]},{"type":"Disulfide bond","location":{"start":{"value":256,"modifier":"EXACT"},"end":{"value":283,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00302"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022875"}],"id":"KW-0180","category":"Biological process","name":"Complement pathway"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023329"}],"id":"KW-0968","category":"Cellular component","name":"Cytoplasmic vesicle"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00302"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023279"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR037971"}],"id":"KW-0278","category":"Biological process","name":"Fertilization"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022859"}],"id":"KW-0391","category":"Biological process","name":"Immunity"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022588"}],"id":"KW-0399","category":"Biological process","name":"Innate immunity"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR037971"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8VRC2"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8VRC2"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022659"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00302"}],"id":"KW-0768","category":"Domain","name":"Sushi"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000640432.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000640432.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16710414","citationType":"journal article","authors":["Gregory S.G.","Barlow K.F.","McLay K.E.","Kaul R.","Swarbreck D.","Dunham A.","Scott C.E.","Howe K.L.","Woodfine K.","Spencer C.C.","Jones M.C.","Gillson C.","Searle S.","Zhou Y.","Kokocinski F.","McDonald L.","Evans R.","Phillips K.","Atkinson A.","Cooper R.","Jones C.","Hall R.E.","Andrews T.D.","Lloyd C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Anderson F.","Andrew R.W.","Ashwell R.I.","Aubin K.","Babbage A.K.","Bagguley C.L.","Bailey J.","Beasley H.","Bethel G.","Bird C.P.","Bray-Allen S.","Brown J.Y.","Brown A.J.","Buckley D.","Burton J.","Bye J.","Carder C.","Chapman J.C.","Clark S.Y.","Clarke G.","Clee C.","Cobley V.","Collier R.E.","Corby N.","Coville G.J.","Davies J.","Deadman R.","Dunn M.","Earthrowl M.","Ellington A.G.","Errington H.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Gay L.","Ghori M.R.","Gibson R.","Gilby L.M.","Gillett W.","Glithero R.J.","Grafham D.V.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Hammond S.","Harrison E.S.","Hart E.","Haugen E.","Heath P.D.","Holmes S.","Holt K.","Howden P.J.","Hunt A.R.","Hunt S.E.","Hunter G.","Isherwood J.","James R.","Johnson C.","Johnson D.","Joy A.","Kay M.","Kershaw J.K.","Kibukawa M.","Kimberley A.M.","King A.","Knights A.J.","Lad H.","Laird G.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Loveland J.","Lovell J.","Lush M.J.","Lyne R.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","Matthews N.S.","McLaren S.","Milne S.","Mistry S.","Moore M.J.","Nickerson T.","O'Dell C.N.","Oliver K.","Palmeiri A.","Palmer S.A.","Parker A.","Patel D.","Pearce A.V.","Peck A.I.","Pelan S.","Phelps K.","Phillimore B.J.","Plumb R.","Rajan J.","Raymond C.","Rouse G.","Saenphimmachak C.","Sehra H.K.","Sheridan E.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.","Steward C.","Subramanian S.","Sycamore N.","Tracey A.","Tromans A.","Van Helmond Z.","Wall M.","Wallis J.M.","White S.","Whitehead S.L.","Wilkinson J.E.","Willey D.L.","Williams H.","Wilming L.","Wray P.W.","Wu Z.","Coulson A.","Vaudin M.","Sulston J.E.","Durbin R.","Hubbard T.","Wooster R.","Dunham I.","Carter N.P.","McVean G.","Ross M.T.","Harrow J.","Olson M.V.","Beck S.","Rogers J.","Bentley D.R.","Banerjee R.","Bryant S.P.","Burford D.C.","Burrill W.D.","Clegg S.M.","Dhami P.","Dovey O.","Faulkner L.M.","Gribble S.M.","Langford C.F.","Pandian R.D.","Porter K.M.","Prigmore E."],"citationCrossReferences":[{"database":"PubMed","id":"16710414"},{"database":"DOI","id":"10.1038/nature04727"}],"title":"The DNA sequence and biological annotation of human chromosome 1.","publicationDate":"2006","journal":"Nature","firstPage":"315","lastPage":"321","volume":"441"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000640432.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000640432.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL035209","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL365178","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000970373.1","properties":[{"key":"ProteinId","value":"ENSP00000640432.1"},{"key":"GeneId","value":"ENSG00000117335.22"}]},{"database":"HGNC","id":"HGNC:6953","properties":[{"key":"GeneName","value":"CD46"}]},{"database":"OpenTargets","id":"ENSG00000117335","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000161381","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"CDD","id":"cd00033","properties":[{"key":"EntryName","value":"CCP"},{"key":"MatchStatus","value":"4"}]},{"database":"FunFam","id":"2.10.70.10:FF:000014","properties":[{"key":"EntryName","value":"Membrane cofactor protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.70.10:FF:000042","properties":[{"key":"EntryName","value":"Membrane cofactor protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.70.10:FF:000046","properties":[{"key":"EntryName","value":"Membrane cofactor protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.70.10:FF:000080","properties":[{"key":"EntryName","value":"Membrane cofactor protein"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.10.70.10","properties":[{"key":"EntryName","value":"Complement Module, domain 1"},{"key":"MatchStatus","value":"4"}]},{"database":"InterPro","id":"IPR017341","properties":[{"key":"EntryName","value":"CD46"}]},{"database":"InterPro","id":"IPR050350","properties":[{"key":"EntryName","value":"Compl-Cell_Adhes-Reg"}]},{"database":"InterPro","id":"IPR035976","properties":[{"key":"EntryName","value":"Sushi/SCR/CCP_sf"}]},{"database":"InterPro","id":"IPR000436","properties":[{"key":"EntryName","value":"Sushi_SCR_CCP_dom"}]},{"database":"PANTHER","id":"PTHR19325","properties":[{"key":"EntryName","value":"COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR19325:SF521","properties":[{"key":"EntryName","value":"MEMBRANE COFACTOR PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00084","properties":[{"key":"EntryName","value":"Sushi"},{"key":"MatchStatus","value":"4"}]},{"database":"PIRSF","id":"PIRSF037971","properties":[{"key":"EntryName","value":"TLX_CD46"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00032","properties":[{"key":"EntryName","value":"CCP"},{"key":"MatchStatus","value":"4"}]},{"database":"SUPFAM","id":"SSF57535","properties":[{"key":"EntryName","value":"Complement control module/SCR domain"},{"key":"MatchStatus","value":"4"}]},{"database":"PROSITE","id":"PS50923","properties":[{"key":"EntryName","value":"SUSHI"},{"key":"MatchStatus","value":"4"}]}],"sequence":{"value":"MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKDVWVIAVIVIAIVVGVAVICVVPYRYLQRRKKKGTYLTDETHREVKFTSL","length":335,"molWeight":37914,"crc64":"79C0A77541DB44AD","md5":"98D504D074B86B1FC9A4B9AC0CE11CFC"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Transmembrane":1,"Domain":4,"Disulfide bond":1},"uniParcId":"UPI004032774A"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8RUE5","uniProtkbId":"A0ACI8RUE5_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000557118.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000557118.1"}],"value":"CD46 molecule"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000557118.1"}],"value":"CD46"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00046288"}],"value":"Endomembrane system","id":"SL-0147"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00046288"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00302"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":34,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":35,"modifier":"EXACT"},"end":{"value":228,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5051248083"},{"type":"Transmembrane","location":{"start":{"value":180,"modifier":"EXACT"},"end":{"value":202,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":96,"modifier":"EXACT"}},"description":"Sushi","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50923"}]},{"type":"Domain","location":{"start":{"value":97,"modifier":"EXACT"},"end":{"value":159,"modifier":"EXACT"}},"description":"Sushi","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50923"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022859"}],"id":"KW-0391","category":"Biological process","name":"Immunity"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022588"}],"id":"KW-0399","category":"Biological process","name":"Innate immunity"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8RUE5"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8RUE5"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022659"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00302"}],"id":"KW-0768","category":"Domain","name":"Sushi"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000557118.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000557118.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16710414","citationType":"journal article","authors":["Gregory S.G.","Barlow K.F.","McLay K.E.","Kaul R.","Swarbreck D.","Dunham A.","Scott C.E.","Howe K.L.","Woodfine K.","Spencer C.C.","Jones M.C.","Gillson C.","Searle S.","Zhou Y.","Kokocinski F.","McDonald L.","Evans R.","Phillips K.","Atkinson A.","Cooper R.","Jones C.","Hall R.E.","Andrews T.D.","Lloyd C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Anderson F.","Andrew R.W.","Ashwell R.I.","Aubin K.","Babbage A.K.","Bagguley C.L.","Bailey J.","Beasley H.","Bethel G.","Bird C.P.","Bray-Allen S.","Brown J.Y.","Brown A.J.","Buckley D.","Burton J.","Bye J.","Carder C.","Chapman J.C.","Clark S.Y.","Clarke G.","Clee C.","Cobley V.","Collier R.E.","Corby N.","Coville G.J.","Davies J.","Deadman R.","Dunn M.","Earthrowl M.","Ellington A.G.","Errington H.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Gay L.","Ghori M.R.","Gibson R.","Gilby L.M.","Gillett W.","Glithero R.J.","Grafham D.V.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Hammond S.","Harrison E.S.","Hart E.","Haugen E.","Heath P.D.","Holmes S.","Holt K.","Howden P.J.","Hunt A.R.","Hunt S.E.","Hunter G.","Isherwood J.","James R.","Johnson C.","Johnson D.","Joy A.","Kay M.","Kershaw J.K.","Kibukawa M.","Kimberley A.M.","King A.","Knights A.J.","Lad H.","Laird G.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Loveland J.","Lovell J.","Lush M.J.","Lyne R.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","Matthews N.S.","McLaren S.","Milne S.","Mistry S.","Moore M.J.","Nickerson T.","O'Dell C.N.","Oliver K.","Palmeiri A.","Palmer S.A.","Parker A.","Patel D.","Pearce A.V.","Peck A.I.","Pelan S.","Phelps K.","Phillimore B.J.","Plumb R.","Rajan J.","Raymond C.","Rouse G.","Saenphimmachak C.","Sehra H.K.","Sheridan E.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.","Steward C.","Subramanian S.","Sycamore N.","Tracey A.","Tromans A.","Van Helmond Z.","Wall M.","Wallis J.M.","White S.","Whitehead S.L.","Wilkinson J.E.","Willey D.L.","Williams H.","Wilming L.","Wray P.W.","Wu Z.","Coulson A.","Vaudin M.","Sulston J.E.","Durbin R.","Hubbard T.","Wooster R.","Dunham I.","Carter N.P.","McVean G.","Ross M.T.","Harrow J.","Olson M.V.","Beck S.","Rogers J.","Bentley D.R.","Banerjee R.","Bryant S.P.","Burford D.C.","Burrill W.D.","Clegg S.M.","Dhami P.","Dovey O.","Faulkner L.M.","Gribble S.M.","Langford C.F.","Pandian R.D.","Porter K.M.","Prigmore E."],"citationCrossReferences":[{"database":"PubMed","id":"16710414"},{"database":"DOI","id":"10.1038/nature04727"}],"title":"The DNA sequence and biological annotation of human chromosome 1.","publicationDate":"2006","journal":"Nature","firstPage":"315","lastPage":"321","volume":"441"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000557118.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000557118.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL035209","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL365178","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000887059.1","properties":[{"key":"ProteinId","value":"ENSP00000557118.1"},{"key":"GeneId","value":"ENSG00000117335.22"}]},{"database":"HGNC","id":"HGNC:6953","properties":[{"key":"GeneName","value":"CD46"}]},{"database":"OpenTargets","id":"ENSG00000117335","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000161381","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"CDD","id":"cd00033","properties":[{"key":"EntryName","value":"CCP"},{"key":"MatchStatus","value":"2"}]},{"database":"FunFam","id":"2.10.70.10:FF:000046","properties":[{"key":"EntryName","value":"Membrane cofactor protein"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.10.70.10","properties":[{"key":"EntryName","value":"Complement Module, domain 1"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR050350","properties":[{"key":"EntryName","value":"Compl-Cell_Adhes-Reg"}]},{"database":"InterPro","id":"IPR035976","properties":[{"key":"EntryName","value":"Sushi/SCR/CCP_sf"}]},{"database":"InterPro","id":"IPR000436","properties":[{"key":"EntryName","value":"Sushi_SCR_CCP_dom"}]},{"database":"PANTHER","id":"PTHR19325","properties":[{"key":"EntryName","value":"COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR19325:SF521","properties":[{"key":"EntryName","value":"MEMBRANE COFACTOR PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00084","properties":[{"key":"EntryName","value":"Sushi"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00032","properties":[{"key":"EntryName","value":"CCP"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF57535","properties":[{"key":"EntryName","value":"Complement control module/SCR domain"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS50923","properties":[{"key":"EntryName","value":"SUSHI"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGPRPTYKPPVSNYPGYPKPEEGILDSLDVWVIAVIVIAIVVGVAVICVVPYRYLQRRKKKGTYLTDETHREVKFTSL","length":228,"molWeight":26084,"crc64":"507DD0654261D110","md5":"FA6CF17B2809A7A4B6E1FB094C63B288"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Transmembrane":1,"Domain":2},"uniParcId":"UPI00403194D1"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"R4GN18","uniProtkbId":"R4GN18_HUMAN","entryAudit":{"firstPublicDate":"2013-06-26","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2013-06-26","entryVersion":66,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000473449.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000473449.1"}],"value":"CD46 molecule"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000473449.1"}],"value":"CD46"}}],"features":[{"type":"Transmembrane","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":48,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Region","location":{"start":{"value":51,"modifier":"EXACT"},"end":{"value":78,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":65,"modifier":"EXACT"},"end":{"value":78,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000473449.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"R4GN18"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"R4GN18"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000473449.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000473449.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16710414","citationType":"journal article","authors":["Gregory S.G.","Barlow K.F.","McLay K.E.","Kaul R.","Swarbreck D.","Dunham A.","Scott C.E.","Howe K.L.","Woodfine K.","Spencer C.C.","Jones M.C.","Gillson C.","Searle S.","Zhou Y.","Kokocinski F.","McDonald L.","Evans R.","Phillips K.","Atkinson A.","Cooper R.","Jones C.","Hall R.E.","Andrews T.D.","Lloyd C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Anderson F.","Andrew R.W.","Ashwell R.I.","Aubin K.","Babbage A.K.","Bagguley C.L.","Bailey J.","Beasley H.","Bethel G.","Bird C.P.","Bray-Allen S.","Brown J.Y.","Brown A.J.","Buckley D.","Burton J.","Bye J.","Carder C.","Chapman J.C.","Clark S.Y.","Clarke G.","Clee C.","Cobley V.","Collier R.E.","Corby N.","Coville G.J.","Davies J.","Deadman R.","Dunn M.","Earthrowl M.","Ellington A.G.","Errington H.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Gay L.","Ghori M.R.","Gibson R.","Gilby L.M.","Gillett W.","Glithero R.J.","Grafham D.V.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Hammond S.","Harrison E.S.","Hart E.","Haugen E.","Heath P.D.","Holmes S.","Holt K.","Howden P.J.","Hunt A.R.","Hunt S.E.","Hunter G.","Isherwood J.","James R.","Johnson C.","Johnson D.","Joy A.","Kay M.","Kershaw J.K.","Kibukawa M.","Kimberley A.M.","King A.","Knights A.J.","Lad H.","Laird G.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Loveland J.","Lovell J.","Lush M.J.","Lyne R.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","Matthews N.S.","McLaren S.","Milne S.","Mistry S.","Moore M.J.","Nickerson T.","O'Dell C.N.","Oliver K.","Palmeiri A.","Palmer S.A.","Parker A.","Patel D.","Pearce A.V.","Peck A.I.","Pelan S.","Phelps K.","Phillimore B.J.","Plumb R.","Rajan J.","Raymond C.","Rouse G.","Saenphimmachak C.","Sehra H.K.","Sheridan E.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.","Steward C.","Subramanian S.","Sycamore N.","Tracey A.","Tromans A.","Van Helmond Z.","Wall M.","Wallis J.M.","White S.","Whitehead S.L.","Wilkinson J.E.","Willey D.L.","Williams H.","Wilming L.","Wray P.W.","Wu Z.","Coulson A.","Vaudin M.","Sulston J.E.","Durbin R.","Hubbard T.","Wooster R.","Dunham I.","Carter N.P.","McVean G.","Ross M.T.","Harrow J.","Olson M.V.","Beck S.","Rogers J.","Bentley D.R.","Banerjee R.","Bryant S.P.","Burford D.C.","Burrill W.D.","Clegg S.M.","Dhami P.","Dovey O.","Faulkner L.M.","Gribble S.M.","Langford C.F.","Pandian R.D.","Porter K.M.","Prigmore E."],"citationCrossReferences":[{"database":"PubMed","id":"16710414"},{"database":"DOI","id":"10.1038/nature04727"}],"title":"The DNA sequence and biological annotation of human chromosome 1.","publicationDate":"2006","journal":"Nature","firstPage":"315","lastPage":"321","volume":"441"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000473449.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"24275569"}]},{"referenceNumber":5,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000473449.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL035209","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL365178","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"MassIVE","id":"R4GN18","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"2378","properties":[{"key":"antibodies","value":"1332 antibodies from 48 providers"}]},{"database":"Ensembl","id":"ENST00000462968.2","properties":[{"key":"ProteinId","value":"ENSP00000473449.1"},{"key":"GeneId","value":"ENSG00000117335.22"}]},{"database":"UCSC","id":"uc057paq.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:6953","properties":[{"key":"GeneName","value":"CD46"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000117335","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000161381","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_2644332_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"6480633at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"CD46","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"Bgee","id":"ENSG00000117335","properties":[{"key":"ExpressionPatterns","value":"Expressed in palpebral conjunctiva and 213 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"R4GN18","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]}],"sequence":{"value":"XPPVSNYPGYPKPEEGILDSLDVWVIAVIVIAIVVGVAVICVVPYRYLQRRKKKGKADGGAEYATYQTKSTTPAEQRG","length":78,"molWeight":8503,"crc64":"76F863A46D99D4EB","md5":"2138E2BFCA2AF3ABAE0D6A09EBB6E795"},"extraAttributes":{"countByFeatureType":{"Transmembrane":1,"Region":1,"Compositional bias":1,"Non-terminal residue":1},"uniParcId":"UPI0002B831D8"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8VQZ1","uniProtkbId":"A0ACI8VQZ1_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000640430.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000640430.1"}],"value":"CD46 molecule"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000640430.1"}],"value":"CD46"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00046288"}],"value":"Endomembrane system","id":"SL-0147"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00046288"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00302"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":34,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":35,"modifier":"EXACT"},"end":{"value":235,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5051221708"},{"type":"Transmembrane","location":{"start":{"value":187,"modifier":"EXACT"},"end":{"value":209,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":96,"modifier":"EXACT"}},"description":"Sushi","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50923"}]},{"type":"Domain","location":{"start":{"value":97,"modifier":"EXACT"},"end":{"value":159,"modifier":"EXACT"}},"description":"Sushi","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50923"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022859"}],"id":"KW-0391","category":"Biological process","name":"Immunity"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022588"}],"id":"KW-0399","category":"Biological process","name":"Innate immunity"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8VQZ1"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8VQZ1"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022659"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00302"}],"id":"KW-0768","category":"Domain","name":"Sushi"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000640430.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000640430.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16710414","citationType":"journal article","authors":["Gregory S.G.","Barlow K.F.","McLay K.E.","Kaul R.","Swarbreck D.","Dunham A.","Scott C.E.","Howe K.L.","Woodfine K.","Spencer C.C.","Jones M.C.","Gillson C.","Searle S.","Zhou Y.","Kokocinski F.","McDonald L.","Evans R.","Phillips K.","Atkinson A.","Cooper R.","Jones C.","Hall R.E.","Andrews T.D.","Lloyd C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Anderson F.","Andrew R.W.","Ashwell R.I.","Aubin K.","Babbage A.K.","Bagguley C.L.","Bailey J.","Beasley H.","Bethel G.","Bird C.P.","Bray-Allen S.","Brown J.Y.","Brown A.J.","Buckley D.","Burton J.","Bye J.","Carder C.","Chapman J.C.","Clark S.Y.","Clarke G.","Clee C.","Cobley V.","Collier R.E.","Corby N.","Coville G.J.","Davies J.","Deadman R.","Dunn M.","Earthrowl M.","Ellington A.G.","Errington H.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Gay L.","Ghori M.R.","Gibson R.","Gilby L.M.","Gillett W.","Glithero R.J.","Grafham D.V.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Hammond S.","Harrison E.S.","Hart E.","Haugen E.","Heath P.D.","Holmes S.","Holt K.","Howden P.J.","Hunt A.R.","Hunt S.E.","Hunter G.","Isherwood J.","James R.","Johnson C.","Johnson D.","Joy A.","Kay M.","Kershaw J.K.","Kibukawa M.","Kimberley A.M.","King A.","Knights A.J.","Lad H.","Laird G.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Loveland J.","Lovell J.","Lush M.J.","Lyne R.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","Matthews N.S.","McLaren S.","Milne S.","Mistry S.","Moore M.J.","Nickerson T.","O'Dell C.N.","Oliver K.","Palmeiri A.","Palmer S.A.","Parker A.","Patel D.","Pearce A.V.","Peck A.I.","Pelan S.","Phelps K.","Phillimore B.J.","Plumb R.","Rajan J.","Raymond C.","Rouse G.","Saenphimmachak C.","Sehra H.K.","Sheridan E.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.","Steward C.","Subramanian S.","Sycamore N.","Tracey A.","Tromans A.","Van Helmond Z.","Wall M.","Wallis J.M.","White S.","Whitehead S.L.","Wilkinson J.E.","Willey D.L.","Williams H.","Wilming L.","Wray P.W.","Wu Z.","Coulson A.","Vaudin M.","Sulston J.E.","Durbin R.","Hubbard T.","Wooster R.","Dunham I.","Carter N.P.","McVean G.","Ross M.T.","Harrow J.","Olson M.V.","Beck S.","Rogers J.","Bentley D.R.","Banerjee R.","Bryant S.P.","Burford D.C.","Burrill W.D.","Clegg S.M.","Dhami P.","Dovey O.","Faulkner L.M.","Gribble S.M.","Langford C.F.","Pandian R.D.","Porter K.M.","Prigmore E."],"citationCrossReferences":[{"database":"PubMed","id":"16710414"},{"database":"DOI","id":"10.1038/nature04727"}],"title":"The DNA sequence and biological annotation of human chromosome 1.","publicationDate":"2006","journal":"Nature","firstPage":"315","lastPage":"321","volume":"441"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000640430.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000640430.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL035209","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL365178","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000970371.1","properties":[{"key":"ProteinId","value":"ENSP00000640430.1"},{"key":"GeneId","value":"ENSG00000117335.22"}]},{"database":"HGNC","id":"HGNC:6953","properties":[{"key":"GeneName","value":"CD46"}]},{"database":"OpenTargets","id":"ENSG00000117335","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000161381","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"CDD","id":"cd00033","properties":[{"key":"EntryName","value":"CCP"},{"key":"MatchStatus","value":"2"}]},{"database":"FunFam","id":"2.10.70.10:FF:000046","properties":[{"key":"EntryName","value":"Membrane cofactor protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.70.10:FF:000080","properties":[{"key":"EntryName","value":"Membrane cofactor protein"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.10.70.10","properties":[{"key":"EntryName","value":"Complement Module, domain 1"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR051277","properties":[{"key":"EntryName","value":"SEZ6_CSMD_C4BPB_Regulators"}]},{"database":"InterPro","id":"IPR035976","properties":[{"key":"EntryName","value":"Sushi/SCR/CCP_sf"}]},{"database":"InterPro","id":"IPR000436","properties":[{"key":"EntryName","value":"Sushi_SCR_CCP_dom"}]},{"database":"PANTHER","id":"PTHR45656","properties":[{"key":"EntryName","value":"PROTEIN CBR-CLEC-78"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR45656:SF4","properties":[{"key":"EntryName","value":"PROTEIN CBR-CLEC-78"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00084","properties":[{"key":"EntryName","value":"Sushi"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00032","properties":[{"key":"EntryName","value":"CCP"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF57535","properties":[{"key":"EntryName","value":"Complement control module/SCR domain"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS50923","properties":[{"key":"EntryName","value":"SUSHI"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICESPRPTYKPPVSNYPGYPKPEEGILDSLDVWVIAVIVIAIVVGVAVICVVPYRYLQRRKKKGTYLTDETHREVKFTSL","length":235,"molWeight":26839,"crc64":"403D3619DAE3163D","md5":"1544A680A268917517987F9780AAB493"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Transmembrane":1,"Domain":2},"uniParcId":"UPI004031E674"}}]}