{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q8N6Q3","secondaryAccessions":["Q711Q2","Q8NCV9","Q96QH1","Q9HDA5"],"uniProtkbId":"CD177_HUMAN","entryAudit":{"firstPublicDate":"2006-04-04","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2006-04-04","entryVersion":148,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:30072"}],"value":"CD177 antigen"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"11465086"}],"value":"Human neutrophil alloantigen 2a"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"11465086"}],"value":"HNA-2a"}]},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"11465086"}],"value":"NB1 glycoprotein"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"11465086"}],"value":"NB1 GP"}]},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"10753836"}],"value":"Polycythemia rubra vera protein 1"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"10753836"}],"value":"PRV-1"}]}],"cdAntigenNames":[{"value":"CD177"}],"flag":"Precursor"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:30072"}],"value":"CD177"},"synonyms":[{"value":"NB1"},{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"10753836"}],"value":"PRV1"}],"orfNames":[{"value":"UNQ595/PRO1181"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17244676"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17580308"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18462208"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21193407"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23202369"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23461681"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28807980"}],"value":"In association with beta-2 integrin heterodimer ITGAM/CD11b and ITGB2/CD18, mediates activation of TNF primed neutrophils including degranulation and superoxide production (PubMed:21193407). In addition, by preventing beta-2 integrin internalization and attenuating chemokine signaling favors adhesion over migration (PubMed:28807980). Heterophilic interaction with PECAM1 on endothelial cells plays a role in neutrophil transendothelial migration in vitro (PubMed:17580308). However, appears to be dispensable for neutrophil recruitment caused by bacterial infection in vivo (PubMed:23461681). Acts as a receptor for the mature form of protease PRTN3 allowing its display at the cell surface of neutrophils (PubMed:17244676, PubMed:18462208). By displaying PRTN3 at the neutrophil cell surface, may play a role in enhancing endothelial cell junctional integrity and thus vascular integrity during neutrophil diapedesis (PubMed:23202369)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17244676"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17580308"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21193407"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28240246"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28807980"}],"value":"Found in a complex with integrin ITGAM/CD11b and ITGB2/CD18 (PubMed:21193407, PubMed:28807980). Interacts with PECAM1 (via Ig-like C2-type domain 6); the interaction is Ca(2+)-dependent; the interaction is direct (PubMed:17580308). Interacts with serine protease PRTN3/myeloblastin; the interaction tethers PRTN3 to the cell surface; the interaction is direct (PubMed:17244676, PubMed:28240246)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q8N6Q3","intActId":"EBI-747170"},"interactantTwo":{"uniProtKBAccession":"Q9Y2W7","geneName":"KCNIP3","intActId":"EBI-751501"},"numberOfExperiments":9,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12239154"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17244676"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17580308"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18462208"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28807980"}],"value":"Cell surface expression on neutrophils is increased upon TNF, fMLP or CXCL8/IL8-mediated stimulation (PubMed:17244676, PubMed:17580308). In neutrophils, stored predominantly in secondary and tertiary granules (PubMed:18462208). Can also be shedded from the cell membrane (PubMed:12239154, PubMed:18462208). Localizes to lamellar protrusions in spreading neutrophils (PubMed:28807980)"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12239154"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12675722"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17244676"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17580308"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18462208"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21193407"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24926686"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27227454"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28240246"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28807980"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12239154"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17244676"}],"value":"Lipid-anchor, GPI-anchor","id":"SL-9902"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21193407"}],"value":"Membrane raft","id":"SL-0370"},"topology":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12239154"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17244676"}],"value":"Lipid-anchor, GPI-like-anchor","id":"SL-9920"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12239154"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18462208"}],"value":"Secreted","id":"SL-0243"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18462208"}],"value":"Cytoplasmic granule membrane","id":"SL-0282"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28807980"}],"value":"Cell projection, lamellipodium","id":"SL-0291"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q8N6Q3-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q8N6Q3-2"],"sequenceIds":["VSP_017860","VSP_017861"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"isoformIds":["Q8N6Q3-3"],"sequenceIds":["VSP_017858","VSP_017859"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10753836"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12377969"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12675722"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17244676"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17580308"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18462208"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21193407"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27227454"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28240246"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28807980"}],"value":"Highly expressed in normal bone marrow and weakly expressed in fetal liver (PubMed:10753836). During neutrophil differentiation, expression begins at the metamyelocyte stage and continues throughout the subsequent stages (at protein level) (PubMed:17244676, PubMed:18462208, PubMed:24926686). Expressed by a subset of mature neutrophils (at protein level) (PubMed:10753836, PubMed:12377969, PubMed:12675722, PubMed:17244676, PubMed:17580308, PubMed:18462208, PubMed:21193407, PubMed:24926686, PubMed:27227454, PubMed:28240246, PubMed:28807980). The percentage of neutrophils expressing CD177 varies across the population (PubMed:17244676, PubMed:27227454). Expressed in granulocytes of patients with polycythemia vera (PV) and with essential thrombocythemia (ET) (PubMed:10753836, PubMed:12377969)"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18462208"}],"value":"Expressed in neonatal and adult neutrophils"}],"commentType":"DEVELOPMENTAL STAGE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10753836"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12377969"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12675722"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17244676"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18462208"}],"value":"By CSF3/G-CSF in resting granulocytes (PubMed:10753836). Induced during CSF3/G-CSF-mediated neutrophil differentiation (PubMed:17244676, PubMed:18462208). Induced during pregnancy (PubMed:12675722). Induced in patients with polycythemia vera (PV) and with essential thrombocythemia (ET) (PubMed:10753836, PubMed:12377969)"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11465086"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12239154"}],"value":"N-glycosylated"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12239154"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18462208"}],"value":"A soluble form may also be produced by proteolytic cleavage at the cell surface (shedding)"}],"commentType":"PTM"},{"commentType":"MASS SPECTROMETRY","method":"MALDI","molWeight":50556.0,"molWeightError":0.0,"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11465086"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12623849"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14692971"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27227454"}],"value":"There is a significant association between the variants Ala-3, Leu-251 and Thr-348 and a low expression of CD177 on neutrophils (PubMed:12623849, PubMed:14692971). Expression of CD177 on neutrophils is a trait determined by ratio of CD177/CD177P1 alleles (PubMed:27227454). The phenotype of CD177 null neutrophils is due to recombination between exon 7 of CD177 and the pseudogene CD177P1 through gene conversion, changing Lys-263 codon into stop codon (PubMed:27227454). The lack of CD177 expression affects 1-10 percent of the population placing them at risk for formation of anti-neutrophil antibodies that can cause transfusion-related acute lung injury and neonatal alloimmune neutropenia"}],"commentType":"POLYMORPHISM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Associated with CD177-negative phenotype"}],"commentType":"MISCELLANEOUS","molecule":"Isoform 2"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Associated with CD177-negative phenotype"}],"commentType":"MISCELLANEOUS","molecule":"Isoform 3"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":21,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15340161"}]},{"type":"Chain","location":{"start":{"value":22,"modifier":"EXACT"},"end":{"value":408,"modifier":"EXACT"}},"description":"CD177 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identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0677","category":"Domain","name":"Repeat"},{"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"10753836","citationType":"journal article","authors":["Temerinac S.","Klippel S.","Strunck E.","Roeder S.","Luebbert M.","Lange W.","Azemar M.","Meinhardt G.","Schaefer H.-E.","Pahl H.L."],"citationCrossReferences":[{"database":"PubMed","id":"10753836"},{"database":"DOI","id":"10.1182/blood.v95.8.2569"}],"title":"Cloning of PRV-1, a novel member of the uPAR receptor superfamily, which is overexpressed in polycythemia rubra vera.","publicationDate":"2000","journal":"Blood","firstPage":"2569","lastPage":"2576","volume":"95"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)","VARIANT ILE-251","TISSUE 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