{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9UK39","secondaryAccessions":["D3DNY5","Q14D51","Q9HD93","Q9HD94","Q9HD95"],"uniProtkbId":"NOCT_HUMAN","entryAudit":{"firstPublicDate":"2001-11-02","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2008-11-04","entryVersion":182,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:14254"}],"value":"Nocturnin"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31147539"}],"value":"3.1.3.108"}]},"alternativeNames":[{"fullName":{"value":"Carbon catabolite repression 4-like protein"}}],"flag":"Precursor"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:14254"}],"value":"NOCT"},"synonyms":[{"value":"CCR4"},{"value":"CCRN4L"},{"value":"NOC"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O35710"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29860338"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31147539"}],"value":"Phosphatase which catalyzes the conversion of NADP(+) to NAD(+) and of NADPH to NADH (PubMed:31147539). Shows a small preference for NADPH over NADP(+) (PubMed:31147539). Represses translation and promotes degradation of target mRNA molecules (PubMed:29860338). Plays an important role in post-transcriptional regulation of metabolic genes under circadian control (By similarity). Exerts a rhythmic post-transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenesis (By similarity). Plays an important role in favoring adipogenesis over osteoblastogenesis and acts as a key regulator of the adipogenesis/osteogenesis balance (By similarity). Promotes adipogenesis by facilitating PPARG nuclear translocation which activates its transcriptional activity (By similarity). Regulates circadian expression of NOS2 in the liver and negatively regulates the circadian expression of IGF1 in the bone (By similarity). Critical for proper development of early embryos (By similarity)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"NADP(+) + H2O = phosphate + NAD(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:28050"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:58349"}],"ecNumber":"3.1.3.108","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31147539"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:28051"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31147539"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"NADPH + H2O = phosphate + NADH","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:60664"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:57945"}],"ecNumber":"3.1.3.108","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31147539"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:60665"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31147539"}]}]},{"commentType":"COFACTOR","cofactors":[{"name":"Mg(2+)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29860338"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30389976"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:18420"}}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29860338"}],"value":"Binds 2 magnesium ions, but the ions are only loosely bound to the protein."}]}},{"commentType":"BIOPHYSICOCHEMICAL PROPERTIES","kineticParameters":{"michaelisConstants":[{"constant":173.0,"unit":"uM","substrate":"NADPH","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31147539"}]}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O35710"}],"value":"Interacts with PPARG"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q9UK39","intActId":"EBI-5655962"},"interactantTwo":{"uniProtKBAccession":"Q8TEM1","geneName":"NUP210","intActId":"EBI-372826"},"numberOfExperiments":2,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O35710"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O35710"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O35710"}],"value":"Cytoplasm, perinuclear region","id":"SL-0198"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31147539"}],"value":"Mitochondrion","id":"SL-0173"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22331129"}],"value":"Adipose tissue. Expression is higher in subcutaneous adipose tissue as compared to visceral adipose tissue"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the CCR4/nocturin family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O35710"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29860338"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30389976"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31147539"}],"value":"Was initially shown to have low deadenylase activity that was lost when the metal-binding Glu was mutated (By similarity). Later studies showed that the purified protein lacked deadenylase activity (PubMed:29860338, PubMed:30389976). Was subsequently shown to act as a phosphatase (PubMed:31147539)"}],"commentType":"CAUTION"}],"features":[{"type":"Transit peptide","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":75,"modifier":"EXACT"}},"description":"Mitochondrion","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Chain","location":{"start":{"value":76,"modifier":"EXACT"},"end":{"value":431,"modifier":"EXACT"}},"description":"Nocturnin","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":"PRO_0000218568"},{"type":"Region","location":{"start":{"value":20,"modifier":"EXACT"},"end":{"value":41,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":343,"modifier":"EXACT"},"end":{"value":353,"modifier":"EXACT"}},"description":"Interaction with PPARG","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O35710"}]},{"type":"Compositional bias","location":{"start":{"value":20,"modifier":"EXACT"},"end":{"value":31,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":32,"modifier":"EXACT"},"end":{"value":41,"modifier":"EXACT"}},"description":"Pro residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Binding site","location":{"start":{"value":195,"modifier":"EXACT"},"end":{"value":195,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29860338"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30389976"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31147539"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6BT1"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6BT2"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6MAL"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6NF0"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420"}},{"type":"Binding site","location":{"start":{"value":195,"modifier":"EXACT"},"end":{"value":195,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31147539"}],"ligand":{"name":"substrate"}},{"type":"Binding site","location":{"start":{"value":219,"modifier":"EXACT"},"end":{"value":221,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31147539"}],"ligand":{"name":"substrate"}},{"type":"Binding site","location":{"start":{"value":263,"modifier":"EXACT"},"end":{"value":263,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31147539"}],"ligand":{"name":"substrate"}},{"type":"Binding site","location":{"start":{"value":286,"modifier":"EXACT"},"end":{"value":289,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31147539"}],"ligand":{"name":"substrate"}},{"type":"Binding site","location":{"start":{"value":324,"modifier":"EXACT"},"end":{"value":326,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31147539"}],"ligand":{"name":"substrate"}},{"type":"Binding site","location":{"start":{"value":414,"modifier":"EXACT"},"end":{"value":414,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31147539"}],"ligand":{"name":"substrate"}},{"type":"Natural variant","location":{"start":{"value":140,"modifier":"EXACT"},"end":{"value":140,"modifier":"EXACT"}},"description":"in dbSNP:rs2271777","featureCrossReferences":[{"database":"dbSNP","id":"rs2271777"}],"featureId":"VAR_047096","alternativeSequence":{"originalSequence":"H","alternativeSequences":["Y"]}},{"type":"Mutagenesis","location":{"start":{"value":149,"modifier":"EXACT"},"end":{"value":149,"modifier":"EXACT"}},"description":"Slightly decreased activity as transcriptional repressor.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29860338"}],"alternativeSequence":{"originalSequence":"N","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":160,"modifier":"EXACT"},"end":{"value":160,"modifier":"EXACT"}},"description":"Lack of catalytic activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31147539"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":195,"modifier":"EXACT"},"end":{"value":195,"modifier":"EXACT"}},"description":"Slightly increased activity as transcriptional repressor. Lack of catalytic activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29860338"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31147539"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":219,"modifier":"EXACT"},"end":{"value":219,"modifier":"EXACT"}},"description":"Reduced catalytic activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31147539"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":286,"modifier":"EXACT"},"end":{"value":286,"modifier":"EXACT"}},"description":"No effect on activity as transcriptional repressor.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29860338"}],"alternativeSequence":{"originalSequence":"H","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":286,"modifier":"EXACT"},"end":{"value":286,"modifier":"EXACT"}},"description":"Lack of catalytic activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31147539"}],"alternativeSequence":{"originalSequence":"H","alternativeSequences":["N"]}},{"type":"Mutagenesis","location":{"start":{"value":288,"modifier":"EXACT"},"end":{"value":288,"modifier":"EXACT"}},"description":"Reduced catalytic activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31147539"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":290,"modifier":"EXACT"},"end":{"value":290,"modifier":"EXACT"}},"description":"Lack of catalytic activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31147539"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":324,"modifier":"EXACT"},"end":{"value":324,"modifier":"EXACT"}},"description":"No effect on activity as transcriptional repressor.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29860338"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":326,"modifier":"EXACT"},"end":{"value":326,"modifier":"EXACT"}},"description":"No effect on activity as transcriptional repressor.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29860338"}],"alternativeSequence":{"originalSequence":"N","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":365,"modifier":"EXACT"},"end":{"value":365,"modifier":"EXACT"}},"description":"No effect on catalytic activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31147539"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":367,"modifier":"EXACT"},"end":{"value":367,"modifier":"EXACT"}},"description":"Reduced catalytic activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31147539"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":377,"modifier":"EXACT"},"end":{"value":377,"modifier":"EXACT"}},"description":"Slightly decreased activity as transcriptional repressor.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29860338"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":414,"modifier":"EXACT"},"end":{"value":414,"modifier":"EXACT"}},"description":"Decreased activity as transcriptional repressor.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29860338"}],"alternativeSequence":{"originalSequence":"H","alternativeSequences":["A","N"]}},{"type":"Sequence conflict","location":{"start":{"value":16,"modifier":"EXACT"},"end":{"value":16,"modifier":"EXACT"}},"description":"in Ref. 1; AAD56548","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["G"]}},{"type":"Sequence conflict","location":{"start":{"value":69,"modifier":"EXACT"},"end":{"value":69,"modifier":"EXACT"}},"description":"in Ref. 4; AAG01387","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"T","alternativeSequences":["N"]}},{"type":"Sequence conflict","location":{"start":{"value":77,"modifier":"EXACT"},"end":{"value":77,"modifier":"EXACT"}},"description":"in Ref. 1; AAD56548","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"A","alternativeSequences":["G"]}},{"type":"Sequence conflict","location":{"start":{"value":266,"modifier":"EXACT"},"end":{"value":266,"modifier":"EXACT"}},"description":"in Ref. 4; AAG01389","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"A","alternativeSequences":["T"]}},{"type":"Sequence conflict","location":{"start":{"value":341,"modifier":"EXACT"},"end":{"value":341,"modifier":"EXACT"}},"description":"in Ref. 1; AAD56548","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["N"]}},{"type":"Helix","location":{"start":{"value":123,"modifier":"EXACT"},"end":{"value":125,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6BT1"}]},{"type":"Beta strand","location":{"start":{"value":129,"modifier":"EXACT"},"end":{"value":131,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6BT1"}]},{"type":"Beta strand","location":{"start":{"value":143,"modifier":"EXACT"},"end":{"value":149,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6BT1"}]},{"type":"Helix","location":{"start":{"value":153,"modifier":"EXACT"},"end":{"value":158,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6BT1"}]},{"type":"Beta strand","location":{"start":{"value":163,"modifier":"EXACT"},"end":{"value":165,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6MAL"}]},{"type":"Helix","location":{"start":{"value":167,"modifier":"EXACT"},"end":{"value":170,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6BT1"}]},{"type":"Helix","location":{"start":{"value":172,"modifier":"EXACT"},"end":{"value":186,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6BT1"}]},{"type":"Beta strand","location":{"start":{"value":189,"modifier":"EXACT"},"end":{"value":195,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6BT1"}]},{"type":"Helix","location":{"start":{"value":199,"modifier":"EXACT"},"end":{"value":203,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6BT1"}]},{"type":"Helix","location":{"start":{"value":204,"modifier":"EXACT"},"end":{"value":209,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6BT1"}]},{"type":"Beta strand","location":{"start":{"value":212,"modifier":"EXACT"},"end":{"value":218,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6BT1"}]},{"type":"Helix","location":{"start":{"value":223,"modifier":"EXACT"},"end":{"value":226,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6BT1"}]},{"type":"Beta strand","location":{"start":{"value":235,"modifier":"EXACT"},"end":{"value":241,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6BT1"}]},{"type":"Turn","location":{"start":{"value":242,"modifier":"EXACT"},"end":{"value":244,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6BT1"}]},{"type":"Beta strand","location":{"start":{"value":245,"modifier":"EXACT"},"end":{"value":257,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6BT1"}]},{"type":"Beta strand","location":{"start":{"value":260,"modifier":"EXACT"},"end":{"value":273,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6BT1"}]},{"type":"Turn","location":{"start":{"value":274,"modifier":"EXACT"},"end":{"value":276,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6BT1"}]},{"type":"Beta strand","location":{"start":{"value":279,"modifier":"EXACT"},"end":{"value":286,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6BT1"}]},{"type":"Helix","location":{"start":{"value":287,"modifier":"EXACT"},"end":{"value":289,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6BT1"}]},{"type":"Helix","location":{"start":{"value":294,"modifier":"EXACT"},"end":{"value":311,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6BT1"}]},{"type":"Turn","location":{"start":{"value":312,"modifier":"EXACT"},"end":{"value":316,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6BT1"}]},{"type":"Beta strand","location":{"start":{"value":319,"modifier":"EXACT"},"end":{"value":324,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6BT1"}]},{"type":"Helix","location":{"start":{"value":332,"modifier":"EXACT"},"end":{"value":339,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6BT1"}]},{"type":"Beta strand","location":{"start":{"value":344,"modifier":"EXACT"},"end":{"value":346,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6BT1"}]},{"type":"Helix","location":{"start":{"value":347,"modifier":"EXACT"},"end":{"value":351,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6BT1"}]},{"type":"Beta strand","location":{"start":{"value":352,"modifier":"EXACT"},"end":{"value":355,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6BT1"}]},{"type":"Beta strand","location":{"start":{"value":362,"modifier":"EXACT"},"end":{"value":367,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6BT1"}]},{"type":"Beta strand","location":{"start":{"value":370,"modifier":"EXACT"},"end":{"value":374,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6BT1"}]},{"type":"Beta strand","location":{"start":{"value":377,"modifier":"EXACT"},"end":{"value":382,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6BT1"}]},{"type":"Turn","location":{"start":{"value":383,"modifier":"EXACT"},"end":{"value":385,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6BT1"}]},{"type":"Beta strand","location":{"start":{"value":386,"modifier":"EXACT"},"end":{"value":392,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6BT1"}]},{"type":"Helix","location":{"start":{"value":393,"modifier":"EXACT"},"end":{"value":396,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6BT1"}]},{"type":"Helix","location":{"start":{"value":397,"modifier":"EXACT"},"end":{"value":400,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6BT1"}]},{"type":"Beta strand","location":{"start":{"value":405,"modifier":"EXACT"},"end":{"value":407,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6BT1"}]},{"type":"Beta strand","location":{"start":{"value":411,"modifier":"EXACT"},"end":{"value":414,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6BT2"}]},{"type":"Beta strand","location":{"start":{"value":417,"modifier":"EXACT"},"end":{"value":423,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6BT1"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0090","category":"Biological process","name":"Biological rhythms"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"id":"KW-0460","category":"Ligand","name":"Magnesium"},{"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0678","category":"Molecular function","name":"Repressor"},{"id":"KW-0694","category":"Molecular function","name":"RNA-binding"},{"id":"KW-0809","category":"Domain","name":"Transit peptide"}],"references":[{"referenceNumber":1,"citation":{"id":"10521507","citationType":"journal article","authors":["Dupressoir A.","Barbot W.","Loireau M.-P.","Heidmann T."],"citationCrossReferences":[{"database":"PubMed","id":"10521507"},{"database":"DOI","id":"10.1074/jbc.274.43.31068"}],"title":"Characterization of a mammalian gene related to the yeast CCR4 general transcription factor and revealed by transposon insertion.","publicationDate":"1999","journal":"J. Biol. Chem.","firstPage":"31068","lastPage":"31075","volume":"274"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"]},{"referenceNumber":2,"citation":{"id":"CI-5GBD0VIIJ7C63","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"SEP-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":3,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"]},{"referenceNumber":4,"citation":{"id":"CI-68NSHF27RIDOG","citationType":"submission","authors":["Wang Y.","Osterbur D.L.","Green C.B.","Besharse J.C."],"title":"Mammalian homologs of Xenopus nocturnin: conservation of structure and circadian regulation.","publicationDate":"OCT-1999","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 67-431"]},{"referenceNumber":5,"citation":{"id":"22331129","citationType":"journal article","authors":["Hee S.W.","Tsai S.H.","Chang Y.C.","Chang C.J.","Yu I.S.","Lee P.C.","Lee W.J.","Yun-Chia Chang E.","Chuang L.M."],"citationCrossReferences":[{"database":"PubMed","id":"22331129"},{"database":"DOI","id":"10.1038/oby.2012.37"}],"title":"The role of nocturnin in early adipogenesis and modulation of systemic insulin resistance in human.","publicationDate":"2012","journal":"Obesity","firstPage":"1558","lastPage":"1565","volume":"20"},"referencePositions":["TISSUE SPECIFICITY"]},{"referenceNumber":6,"citation":{"id":"22608110","citationType":"journal article","authors":["Stubblefield J.J.","Terrien J.","Green C.B."],"citationCrossReferences":[{"database":"PubMed","id":"22608110"},{"database":"DOI","id":"10.1016/j.tem.2012.03.007"}],"title":"Nocturnin: at the crossroads of clocks and metabolism.","publicationDate":"2012","journal":"Trends Endocrinol. Metab.","firstPage":"326","lastPage":"333","volume":"23"},"referencePositions":["REVIEW"]},{"referenceNumber":7,"citation":{"id":"29860338","citationType":"journal article","authors":["Abshire E.T.","Chasseur J.","Bohn J.A.","Del Rizzo P.A.","Freddolino P.L.","Goldstrohm A.C.","Trievel R.C."],"citationCrossReferences":[{"database":"PubMed","id":"29860338"},{"database":"DOI","id":"10.1093/nar/gky412"}],"title":"The structure of human Nocturnin reveals a conserved ribonuclease domain that represses target transcript translation and abundance in cells.","publicationDate":"2018","journal":"Nucleic Acids Res.","firstPage":"6257","lastPage":"6270","volume":"46"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.48 ANGSTROMS) OF 120-431 IN COMPLEX WITH MAGNESIUM","FUNCTION","COFACTOR","LACK OF ADENYLASE ACTIVITY","MUTAGENESIS OF ASN-149; GLU-195; HIS-286; ASP-324; ASN-326; ASP-377 AND HIS-414"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"6BT1"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6BT2"}]},{"referenceNumber":8,"citation":{"id":"30389976","citationType":"journal article","authors":["Estrella M.A.","Du J.","Korennykh A."],"citationCrossReferences":[{"database":"PubMed","id":"30389976"},{"database":"DOI","id":"10.1038/s41598-018-34615-0"}],"title":"Crystal Structure of Human Nocturnin Catalytic Domain.","publicationDate":"2018","journal":"Sci. Rep.","firstPage":"16294","lastPage":"16294","volume":"8"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) OF 122-431 IN COMPLEX WITH MAGNESIUM","LACK OF ADENYLASE ACTIVITY"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"6MAL"}]},{"referenceNumber":9,"citation":{"id":"31147539","citationType":"journal article","authors":["Estrella M.A.","Du J.","Chen L.","Rath S.","Prangley E.","Chitrakar A.","Aoki T.","Schedl P.","Rabinowitz J.","Korennykh A."],"citationCrossReferences":[{"database":"PubMed","id":"31147539"},{"database":"DOI","id":"10.1038/s41467-019-10125-z"}],"title":"The metabolites NADP+ and NADPH are the targets of the circadian protein Nocturnin (Curled).","publicationDate":"2019","journal":"Nat. Commun.","firstPage":"2367","lastPage":"2367","volume":"10"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.70 ANGSTROMS) OF 122-431 IN COMPLEX WITH METAL AND NADPH","FUNCTION","SUBCELLULAR LOCATION","BIOPHYSICOCHEMICAL PROPERTIES","MUTAGENESIS OF ASP-160; GLU-195; LYS-219; HIS-286; LYS-288; ARG-290; LYS-365 AND ARG-367"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AF183961","properties":[{"key":"ProteinId","value":"AAD56548.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"CH471056","properties":[{"key":"ProteinId","value":"EAX05129.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471056","properties":[{"key":"ProteinId","value":"EAX05131.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC113494","properties":[{"key":"ProteinId","value":"AAI13495.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC113500","properties":[{"key":"ProteinId","value":"AAI13501.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF199492","properties":[{"key":"ProteinId","value":"AAG01387.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF199493","properties":[{"key":"ProteinId","value":"AAG01388.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF199494","properties":[{"key":"ProteinId","value":"AAG01389.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Transcribed_RNA"}]},{"database":"CCDS","id":"CCDS3743.1","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_036250.2","properties":[{"key":"NucleotideSequenceId","value":"NM_012118.4"}]},{"database":"PDB","id":"6BT1","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.48 A"},{"key":"Chains","value":"A=120-431"}]},{"database":"PDB","id":"6BT2","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.41 A"},{"key":"Chains","value":"A/B=120-431"}]},{"database":"PDB","id":"6MAL","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.60 A"},{"key":"Chains","value":"A=122-431"}]},{"database":"PDB","id":"6NF0","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.70 A"},{"key":"Chains","value":"A=122-431"}]},{"database":"PDBsum","id":"6BT1","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6BT2","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6MAL","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6NF0","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"Q9UK39","properties":[{"key":"Description","value":"-"}]},{"database":"SASBDB","id":"Q9UK39","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q9UK39","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"117347","properties":[{"key":"Interactions","value":"76"}]},{"database":"FunCoup","id":"Q9UK39","properties":[{"key":"Number of interactors","value":"2186"}]},{"database":"IntAct","id":"Q9UK39","properties":[{"key":"Interactions","value":"47"}]},{"database":"NDEx","id":"IQUERY-CP-NOCT","properties":[{"key":"Evidences","value":"1 NDEx IQuery Curated Pathway"}]},{"database":"STRING","id":"9606.ENSP00000280614","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"Q9UK39","properties":[{"key":"glycosylation","value":"1 site, 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"Q9UK39","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q9UK39","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"NOCT","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"212276446","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q9UK39","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q9UK39","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000280614","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q9UK39","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"84714","properties":[{"key":"Description","value":"-"}]},{"database":"Pumba","id":"Q9UK39","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"16153","properties":[{"key":"antibodies","value":"126 antibodies from 31 providers"}]},{"database":"DNASU","id":"25819","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000280614.4","properties":[{"key":"ProteinId","value":"ENSP00000280614.2"},{"key":"GeneId","value":"ENSG00000151014.7"}]},{"database":"GeneID","id":"25819","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:25819","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000280614.4","properties":[{"key":"ProteinId","value":"ENSP00000280614.2"},{"key":"RefSeqNucleotideId","value":"NM_012118.4"},{"key":"RefSeqProteinId","value":"NP_036250.2"}]},{"database":"UCSC","id":"uc003ihl.5","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:14254","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA26176","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"25819","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"25819","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"NOCT","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:14254","properties":[{"key":"GeneName","value":"NOCT"}]},{"database":"HPA","id":"ENSG00000151014","properties":[{"key":"ExpressionPatterns","value":"Tissue enhanced (bone)"}]},{"database":"MIM","id":"608468","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000151014","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000151014","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG0620","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000155249","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_016428_1_2_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q9UK39","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"RAACSMG","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"276515at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q9UK39","properties":[{"key":"Number of GO annotations","value":"1 GO annotation based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q9UK39","properties":[{"key":"Description","value":"-"}]},{"database":"BioCyc","id":"MetaCyc:ENSG00000151014-MONOMER","properties":[{"key":"Description","value":"-"}]},{"database":"BRENDA","id":"3.1.3.108","properties":[{"key":"OrganismId","value":"2681"}]},{"database":"PathwayCommons","id":"Q9UK39","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-1368108","properties":[{"key":"PathwayName","value":"BMAL1:CLOCK,NPAS2 activates circadian expression"}]},{"database":"SignaLink","id":"Q9UK39","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000151014","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"25819","properties":[{"key":"hits","value":"19 hits in 1140 CRISPR screens"}]},{"database":"ChiTaRS","id":"NOCT","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GenomeRNAi","id":"25819","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q9UK39","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:Q9UK39","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 4"}]},{"database":"RNAct","id":"Q9UK39","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000151014","properties":[{"key":"ExpressionPatterns","value":"Expressed in buccal mucosa cell and 117 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q9UK39","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005739","properties":[{"key":"GoTerm","value":"C:mitochondrion"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"31147539"}]},{"database":"GO","id":"GO:0016604","properties":[{"key":"GoTerm","value":"C:nuclear body"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0000932","properties":[{"key":"GoTerm","value":"C:P-body"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0048471","properties":[{"key":"GoTerm","value":"C:perinuclear region of cytoplasm"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0000175","properties":[{"key":"GoTerm","value":"F:3'-5'-RNA exonuclease activity"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0003729","properties":[{"key":"GoTerm","value":"F:mRNA binding"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0019178","properties":[{"key":"GoTerm","value":"F:NADP phosphatase activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"31147539"}]},{"database":"GO","id":"GO:0102757","properties":[{"key":"GoTerm","value":"F:NADPH phosphatase activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"31147539"}]},{"database":"GO","id":"GO:0004535","properties":[{"key":"GoTerm","value":"F:poly(A)-specific ribonuclease activity"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0032922","properties":[{"key":"GoTerm","value":"P:circadian regulation of gene expression"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0007623","properties":[{"key":"GoTerm","value":"P:circadian rhythm"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0006402","properties":[{"key":"GoTerm","value":"P:mRNA catabolic process"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0048255","properties":[{"key":"GoTerm","value":"P:mRNA stabilization"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0006739","properties":[{"key":"GoTerm","value":"P:NADP+ metabolic process"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"31147539"}]},{"database":"GO","id":"GO:0010629","properties":[{"key":"GoTerm","value":"P:negative regulation of gene expression"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0045668","properties":[{"key":"GoTerm","value":"P:negative regulation of osteoblast differentiation"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0045600","properties":[{"key":"GoTerm","value":"P:positive regulation of fat cell differentiation"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0042752","properties":[{"key":"GoTerm","value":"P:regulation of circadian rhythm"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0045995","properties":[{"key":"GoTerm","value":"P:regulation of embryonic development"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0032496","properties":[{"key":"GoTerm","value":"P:response to lipopolysaccharide"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0006366","properties":[{"key":"GoTerm","value":"P:transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"10521507"}]},{"database":"CDD","id":"cd09096","properties":[{"key":"EntryName","value":"Deadenylase_nocturnin"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.60.10.10:FF:000012","properties":[{"key":"EntryName","value":"nocturnin isoform X2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.60.10.10","properties":[{"key":"EntryName","value":"Endonuclease/exonuclease/phosphatase"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR050410","properties":[{"key":"EntryName","value":"CCR4/nocturin_mRNA_transcr"}]},{"database":"InterPro","id":"IPR034965","properties":[{"key":"EntryName","value":"Deadenylase_nocturnin"}]},{"database":"InterPro","id":"IPR036691","properties":[{"key":"EntryName","value":"Endo/exonu/phosph_ase_sf"}]},{"database":"InterPro","id":"IPR005135","properties":[{"key":"EntryName","value":"Endo/exonuclease/phosphatase"}]},{"database":"PANTHER","id":"PTHR12121","properties":[{"key":"EntryName","value":"CARBON CATABOLITE REPRESSOR PROTEIN 4"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR12121:SF45","properties":[{"key":"EntryName","value":"NOCTURNIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF03372","properties":[{"key":"EntryName","value":"Exo_endo_phos"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56219","properties":[{"key":"EntryName","value":"DNase I-like"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MFHSPRRLCSALLQRDAPGLRRLPAPGLRRPLSPPAAVPRPASPRLLAAASAASGAARSCSRTVCSMGTGTSRLYSALAKTLNSSAASQHPEYLVSPDPEHLEPIDPKELLEECRAVLHTRPPRFQRDFVDLRTDCPSTHPPIRVMQWNILAQALGEGKDNFVQCPVEALKWEERKCLILEEILAYQPDILCLQEVDHYFDTFQPLLSRLGYQGTFFPKPWSPCLDVEHNNGPDGCALFFLQNRFKLVNSANIRLTAMTLKTNQVAIAQTLECKESGRQFCIAVTHLKARTGWERFRSAQGCDLLQNLQNITQGAKIPLIVCGDFNAEPTEEVYKHFASSSLNLNSAYKLLSADGQSEPPYTTWKIRTSGECRHTLDYIWYSKHALNVRSALDLLTEEQIGPNRLPSFNYPSDHLSLVCDFSFTEESDGLS","length":431,"molWeight":48196,"crc64":"5BDEFC43173B2D0C","md5":"B1D0AAEC2C9D69394C2EC0AA31B20235"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":2,"COFACTOR":1,"BIOPHYSICOCHEMICAL PROPERTIES":1,"SUBUNIT":1,"INTERACTION":1,"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Transit peptide":1,"Chain":1,"Region":2,"Compositional bias":2,"Binding site":7,"Natural variant":1,"Mutagenesis":14,"Sequence conflict":5,"Helix":13,"Beta strand":19,"Turn":4},"uniParcId":"UPI000013DC2C"}},{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9ULM6","secondaryAccessions":["A7MD46","D3DWR0"],"uniProtkbId":"CNOT6_HUMAN","entryAudit":{"firstPublicDate":"2004-04-13","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2004-04-13","entryVersion":200,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"CCR4-NOT transcription complex subunit 6"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11889047"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20065043"}],"value":"3.1.13.4"}]},"alternativeNames":[{"fullName":{"value":"CCR4 carbon catabolite repression 4-like"}},{"fullName":{"value":"Carbon catabolite repressor protein 4 homolog"}},{"fullName":{"value":"Cytoplasmic deadenylase"}}]},"genes":[{"geneName":{"value":"CNOT6"},"synonyms":[{"value":"CCR4"},{"value":"CCR4a"},{"value":"KIAA1194"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11889047"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18180299"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20065043"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21233283"}],"value":"Poly(A) nuclease with 3'-5' RNase activity. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the FOS gene in the cytoplasm. In the presence of ZNF335, enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA. The increase of ligand-dependent ESR1-mediated transcription is much smaller, if any. Mediates cell proliferation and cell survival and prevents cellular senescence"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"Exonucleolytic cleavage of poly(A) to 5'-AMP.","ecNumber":"3.1.13.4","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11889047"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20065043"}]}},{"commentType":"COFACTOR","cofactors":[{"name":"Mg(2+)","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q96LI5"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:18420"}}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q96LI5"}],"value":"Binds 2 magnesium ions, but the ions interact each with only 1 or 2 residues."}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11747467"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15314026"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15687258"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18180299"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19558367"}],"value":"Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits; the complex contains two deadenylase subunits, CNOT6 or CNOT6L, and CNOT7 or CNOT8 (PubMed:19558367). Interacts with CNOT7 and CNOT8 (PubMed:11747467). Interacts with UNR (PubMed:15314026). Interacts with ZFP36L1 (via N-terminus) (PubMed:15687258). Interacts with ZNF335 (PubMed:18180299)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q9ULM6","intActId":"EBI-2104530"},"interactantTwo":{"uniProtKBAccession":"A5YKK6","geneName":"CNOT1","intActId":"EBI-1222758"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9ULM6","intActId":"EBI-2104530"},"interactantTwo":{"uniProtKBAccession":"Q9H9A5","geneName":"CNOT10","intActId":"EBI-1054261"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9ULM6","intActId":"EBI-2104530"},"interactantTwo":{"uniProtKBAccession":"O75175","geneName":"CNOT3","intActId":"EBI-743073"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9ULM6","intActId":"EBI-2104530"},"interactantTwo":{"uniProtKBAccession":"Q9UIV1","geneName":"CNOT7","intActId":"EBI-2105113"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9ULM6","intActId":"EBI-2104530"},"interactantTwo":{"uniProtKBAccession":"Q9UFF9","geneName":"CNOT8","intActId":"EBI-742299"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9ULM6","intActId":"EBI-2104530"},"interactantTwo":{"uniProtKBAccession":"Q86TB9","geneName":"PATL1","intActId":"EBI-2562092"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9ULM6","intActId":"EBI-2104530"},"interactantTwo":{"uniProtKBAccession":"Q9HCJ0","geneName":"TNRC6C","intActId":"EBI-6507625"},"numberOfExperiments":2,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q96LI5"}],"value":"Predominantly cytoplasmic"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q96LI5"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q96LI5"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the CCR4/nocturin family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":557,"modifier":"EXACT"}},"description":"CCR4-NOT transcription complex subunit 6","featureId":"PRO_0000218573"},{"type":"Repeat","location":{"start":{"value":52,"modifier":"EXACT"},"end":{"value":73,"modifier":"EXACT"}},"description":"LRR 1"},{"type":"Repeat","location":{"start":{"value":75,"modifier":"EXACT"},"end":{"value":96,"modifier":"EXACT"}},"description":"LRR 2"},{"type":"Repeat","location":{"start":{"value":98,"modifier":"EXACT"},"end":{"value":120,"modifier":"EXACT"}},"description":"LRR 3"},{"type":"Repeat","location":{"start":{"value":121,"modifier":"EXACT"},"end":{"value":143,"modifier":"EXACT"}},"description":"LRR 4"},{"type":"Region","location":{"start":{"value":153,"modifier":"EXACT"},"end":{"value":557,"modifier":"EXACT"}},"description":"Nuclease domain","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Active site","location":{"start":{"value":412,"modifier":"EXACT"},"end":{"value":412,"modifier":"EXACT"}},"description":"Proton donor/acceptor","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q96LI5"}]},{"type":"Binding site","location":{"start":{"value":240,"modifier":"EXACT"},"end":{"value":240,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q96LI5"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420","label":"1"}},{"type":"Binding site","location":{"start":{"value":240,"modifier":"EXACT"},"end":{"value":240,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q96LI5"}],"ligand":{"name":"substrate"}},{"type":"Binding site","location":{"start":{"value":276,"modifier":"EXACT"},"end":{"value":276,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q96LI5"}],"ligand":{"name":"substrate"}},{"type":"Binding site","location":{"start":{"value":361,"modifier":"EXACT"},"end":{"value":361,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q96LI5"}],"ligand":{"name":"substrate"}},{"type":"Binding site","location":{"start":{"value":366,"modifier":"EXACT"},"end":{"value":366,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q96LI5"}],"ligand":{"name":"substrate"}},{"type":"Binding site","location":{"start":{"value":412,"modifier":"EXACT"},"end":{"value":412,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q96LI5"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420","label":"2"}},{"type":"Binding site","location":{"start":{"value":414,"modifier":"EXACT"},"end":{"value":414,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q96LI5"}],"ligand":{"name":"substrate"}},{"type":"Binding site","location":{"start":{"value":481,"modifier":"EXACT"},"end":{"value":481,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q96LI5"}],"ligand":{"name":"substrate"}},{"type":"Binding site","location":{"start":{"value":486,"modifier":"EXACT"},"end":{"value":486,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q96LI5"}],"ligand":{"name":"substrate"}},{"type":"Mutagenesis","location":{"start":{"value":240,"modifier":"EXACT"},"end":{"value":240,"modifier":"EXACT"}},"description":"Impairs deadenylation and decay of mRNAi-targeted mRNA.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20065043"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["A"]}},{"type":"Helix","location":{"start":{"value":7,"modifier":"EXACT"},"end":{"value":9,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7AX1"}]},{"type":"Helix","location":{"start":{"value":19,"modifier":"EXACT"},"end":{"value":25,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7AX1"}]},{"type":"Beta strand","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":36,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7AX1"}]},{"type":"Helix","location":{"start":{"value":45,"modifier":"EXACT"},"end":{"value":47,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7AX1"}]},{"type":"Beta strand","location":{"start":{"value":55,"modifier":"EXACT"},"end":{"value":57,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7AX1"}]},{"type":"Helix","location":{"start":{"value":68,"modifier":"EXACT"},"end":{"value":72,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7AX1"}]},{"type":"Helix","location":{"start":{"value":92,"modifier":"EXACT"},"end":{"value":95,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7AX1"}]},{"type":"Beta strand","location":{"start":{"value":101,"modifier":"EXACT"},"end":{"value":103,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7AX1"}]},{"type":"Helix","location":{"start":{"value":114,"modifier":"EXACT"},"end":{"value":118,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7AX1"}]},{"type":"Beta strand","location":{"start":{"value":124,"modifier":"EXACT"},"end":{"value":126,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7AX1"}]},{"type":"Helix","location":{"start":{"value":134,"modifier":"EXACT"},"end":{"value":141,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7AX1"}]},{"type":"Helix","location":{"start":{"value":145,"modifier":"EXACT"},"end":{"value":160,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7AX1"}]},{"type":"Helix","location":{"start":{"value":169,"modifier":"EXACT"},"end":{"value":173,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7AX1"}]},{"type":"Beta strand","location":{"start":{"value":174,"modifier":"EXACT"},"end":{"value":176,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7AX1"}]},{"type":"Beta strand","location":{"start":{"value":186,"modifier":"EXACT"},"end":{"value":195,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7AX1"}]},{"type":"Turn","location":{"start":{"value":204,"modifier":"EXACT"},"end":{"value":206,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7AX1"}]},{"type":"Helix","location":{"start":{"value":212,"modifier":"EXACT"},"end":{"value":215,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7AX1"}]},{"type":"Helix","location":{"start":{"value":217,"modifier":"EXACT"},"end":{"value":231,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7AX1"}]},{"type":"Beta strand","location":{"start":{"value":234,"modifier":"EXACT"},"end":{"value":240,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7AX1"}]},{"type":"Helix","location":{"start":{"value":246,"modifier":"EXACT"},"end":{"value":250,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7AX1"}]},{"type":"Helix","location":{"start":{"value":251,"modifier":"EXACT"},"end":{"value":255,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7AX1"}]},{"type":"Turn","location":{"start":{"value":256,"modifier":"EXACT"},"end":{"value":258,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7AX1"}]},{"type":"Helix","location":{"start":{"value":274,"modifier":"EXACT"},"end":{"value":278,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7AX1"}]},{"type":"Beta strand","location":{"start":{"value":284,"modifier":"EXACT"},"end":{"value":288,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7AX1"}]},{"type":"Turn","location":{"start":{"value":289,"modifier":"EXACT"},"end":{"value":291,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7AX1"}]},{"type":"Beta strand","location":{"start":{"value":296,"modifier":"EXACT"},"end":{"value":299,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7AX1"}]},{"type":"Helix","location":{"start":{"value":311,"modifier":"EXACT"},"end":{"value":320,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7AX1"}]},{"type":"Beta strand","location":{"start":{"value":327,"modifier":"EXACT"},"end":{"value":334,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7AX1"}]},{"type":"Beta strand","location":{"start":{"value":354,"modifier":"EXACT"},"end":{"value":361,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7AX1"}]},{"type":"Helix","location":{"start":{"value":366,"modifier":"EXACT"},"end":{"value":368,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7AX1"}]},{"type":"Helix","location":{"start":{"value":369,"modifier":"EXACT"},"end":{"value":393,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7AX1"}]},{"type":"Beta strand","location":{"start":{"value":407,"modifier":"EXACT"},"end":{"value":412,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7AX1"}]},{"type":"Helix","location":{"start":{"value":420,"modifier":"EXACT"},"end":{"value":426,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7AX1"}]},{"type":"Beta strand","location":{"start":{"value":427,"modifier":"EXACT"},"end":{"value":431,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7AX1"}]},{"type":"Helix","location":{"start":{"value":435,"modifier":"EXACT"},"end":{"value":440,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7AX1"}]},{"type":"Helix","location":{"start":{"value":446,"modifier":"EXACT"},"end":{"value":449,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7AX1"}]},{"type":"Beta strand","location":{"start":{"value":461,"modifier":"EXACT"},"end":{"value":463,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7AX1"}]},{"type":"Turn","location":{"start":{"value":471,"modifier":"EXACT"},"end":{"value":475,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7AX1"}]},{"type":"Beta strand","location":{"start":{"value":476,"modifier":"EXACT"},"end":{"value":478,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7AX1"}]},{"type":"Beta strand","location":{"start":{"value":480,"modifier":"EXACT"},"end":{"value":482,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7AX1"}]},{"type":"Beta strand","location":{"start":{"value":491,"modifier":"EXACT"},"end":{"value":496,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7AX1"}]},{"type":"Turn","location":{"start":{"value":497,"modifier":"EXACT"},"end":{"value":499,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7AX1"}]},{"type":"Beta strand","location":{"start":{"value":500,"modifier":"EXACT"},"end":{"value":506,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7AX1"}]},{"type":"Helix","location":{"start":{"value":511,"modifier":"EXACT"},"end":{"value":516,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7AX1"}]},{"type":"Beta strand","location":{"start":{"value":521,"modifier":"EXACT"},"end":{"value":524,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7AX1"}]},{"type":"Beta strand","location":{"start":{"value":529,"modifier":"EXACT"},"end":{"value":531,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7AX1"}]},{"type":"Beta strand","location":{"start":{"value":536,"modifier":"EXACT"},"end":{"value":541,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7AX1"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0010","category":"Molecular function","name":"Activator"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0269","category":"Molecular function","name":"Exonuclease"},{"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"id":"KW-0433","category":"Domain","name":"Leucine-rich repeat"},{"id":"KW-0460","category":"Ligand","name":"Magnesium"},{"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"id":"KW-0540","category":"Molecular function","name":"Nuclease"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0677","category":"Domain","name":"Repeat"},{"id":"KW-0694","category":"Molecular function","name":"RNA-binding"},{"id":"KW-0943","category":"Biological process","name":"RNA-mediated gene silencing"},{"id":"KW-0804","category":"Biological process","name":"Transcription"},{"id":"KW-0805","category":"Biological process","name":"Transcription regulation"},{"id":"KW-0810","category":"Biological process","name":"Translation regulation"}],"references":[{"referenceNumber":1,"citation":{"id":"10574462","citationType":"journal article","authors":["Nagase T.","Ishikawa K.","Kikuno R.","Hirosawa M.","Nomura N.","Ohara O."],"citationCrossReferences":[{"database":"PubMed","id":"10574462"},{"database":"DOI","id":"10.1093/dnares/6.5.337"}],"title":"Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.","publicationDate":"1999","journal":"DNA Res.","firstPage":"337","lastPage":"345","volume":"6"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"CI-5GBD0VIIJ7C63","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"SEP-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":3,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"]},{"referenceNumber":4,"citation":{"id":"11747467","citationType":"journal article","authors":["Dupressoir A.","Morel A.-P.","Barbot W.","Loireau M.-P.","Corbo L.","Heidmann T."],"citationCrossReferences":[{"database":"PubMed","id":"11747467"},{"database":"DOI","id":"10.1186/1471-2164-2-9"}],"title":"Identification of four families of yCCR4- and Mg2+-dependent endonuclease-related proteins in higher eukaryotes, and characterization of orthologs of yCCR4 with a conserved leucine-rich repeat essential for hCAF1/hPOP2 binding.","publicationDate":"2001","journal":"BMC Genomics","firstPage":"9","lastPage":"9","volume":"2"},"referencePositions":["INTERACTION WITH CNOT7 AND CNOT8"]},{"referenceNumber":5,"citation":{"id":"11889047","citationType":"journal article","authors":["Chen J.","Chiang Y.-C.","Denis C.L."],"citationCrossReferences":[{"database":"PubMed","id":"11889047"},{"database":"DOI","id":"10.1093/emboj/21.6.1414"}],"title":"CCR4, a 3'-5' poly(A) RNA and ssDNA exonuclease, is the catalytic component of the cytoplasmic deadenylase.","publicationDate":"2002","journal":"EMBO J.","firstPage":"1414","lastPage":"1426","volume":"21"},"referencePositions":["FUNCTION","CATALYTIC ACTIVITY"]},{"referenceNumber":6,"citation":{"id":"15314026","citationType":"journal article","authors":["Chang T.-C.","Yamashita A.","Chen C.-Y.A.","Yamashita Y.","Zhu W.","Durdan S.","Kahvejian A.","Sonenberg N.","Shyu A.-B."],"citationCrossReferences":[{"database":"PubMed","id":"15314026"},{"database":"DOI","id":"10.1101/gad.1219104"}],"title":"UNR, a new partner of poly(A)-binding protein, plays a key role in translationally coupled mRNA turnover mediated by the c-fos major coding-region determinant.","publicationDate":"2004","journal":"Genes Dev.","firstPage":"2010","lastPage":"2023","volume":"18"},"referencePositions":["INTERACTION WITH UNR"]},{"referenceNumber":7,"citation":{"id":"15687258","citationType":"journal article","authors":["Lykke-Andersen J.","Wagner E."],"citationCrossReferences":[{"database":"PubMed","id":"15687258"},{"database":"DOI","id":"10.1101/gad.1282305"}],"title":"Recruitment and activation of mRNA decay enzymes by two ARE-mediated decay activation domains in the proteins TTP and BRF-1.","publicationDate":"2005","journal":"Genes Dev.","firstPage":"351","lastPage":"361","volume":"19"},"referencePositions":["INTERACTION WITH ZFP36L1"]},{"referenceNumber":8,"citation":{"id":"18180299","citationType":"journal article","authors":["Garapaty S.","Mahajan M.A.","Samuels H.H."],"citationCrossReferences":[{"database":"PubMed","id":"18180299"},{"database":"DOI","id":"10.1074/jbc.m706986200"}],"title":"Components of the CCR4-NOT complex function as nuclear hormone receptor coactivators via association with the NRC-interacting Factor NIF-1.","publicationDate":"2008","journal":"J. Biol. Chem.","firstPage":"6806","lastPage":"6816","volume":"283"},"referencePositions":["FUNCTION","INTERACTION WITH ZNF335"]},{"referenceNumber":9,"citation":{"id":"19558367","citationType":"journal article","authors":["Lau N.C.","Kolkman A.","van Schaik F.M.","Mulder K.W.","Pijnappel W.W.","Heck A.J.","Timmers H.T."],"citationCrossReferences":[{"database":"PubMed","id":"19558367"},{"database":"DOI","id":"10.1042/bj20090500"}],"title":"Human Ccr4-Not complexes contain variable deadenylase subunits.","publicationDate":"2009","journal":"Biochem. J.","firstPage":"443","lastPage":"453","volume":"422"},"referencePositions":["IDENTIFICATION IN THE CCR4-NOT COMPLEX","COMPOSITION OF THE CCR4-NOT COMPLEX"]},{"referenceNumber":10,"citation":{"id":"20065043","citationType":"journal article","authors":["Piao X.","Zhang X.","Wu L.","Belasco J.G."],"citationCrossReferences":[{"database":"PubMed","id":"20065043"},{"database":"DOI","id":"10.1128/mcb.01481-09"}],"title":"CCR4-NOT deadenylates mRNA associated with complexes in human cells.","publicationDate":"2010","journal":"Mol. Cell. Biol.","firstPage":"1486","lastPage":"1494","volume":"30"},"referencePositions":["FUNCTION","CATALYTIC ACTIVITY","MUTAGENESIS OF GLU-240"]},{"referenceNumber":11,"citation":{"id":"21233283","citationType":"journal article","authors":["Mittal S.","Aslam A.","Doidge R.","Medica R.","Winkler G.S."],"citationCrossReferences":[{"database":"PubMed","id":"21233283"},{"database":"DOI","id":"10.1091/mbc.e10-11-0898"}],"title":"The Ccr4a (CNOT6) and Ccr4b (CNOT6L) deadenylase subunits of the human Ccr4-Not complex contribute to the prevention of cell death and senescence.","publicationDate":"2011","journal":"Mol. Biol. Cell","firstPage":"748","lastPage":"758","volume":"22"},"referencePositions":["FUNCTION"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AB033020","properties":[{"key":"ProteinId","value":"BAA86508.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"CH471165","properties":[{"key":"ProteinId","value":"EAW53752.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471165","properties":[{"key":"ProteinId","value":"EAW53753.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC152469","properties":[{"key":"ProteinId","value":"AAI52470.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS4455.1","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_001357401.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001370472.1"}]},{"database":"RefSeq","id":"XP_047273392.1","properties":[{"key":"NucleotideSequenceId","value":"XM_047417436.1"}]},{"database":"RefSeq","id":"XP_054208966.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054352991.1"}]},{"database":"PDB","id":"7AX1","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.30 A"},{"key":"Chains","value":"A=1-557"}]},{"database":"PDBsum","id":"7AX1","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"Q9ULM6","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q9ULM6","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"121542","properties":[{"key":"Interactions","value":"64"}]},{"database":"ComplexPortal","id":"CPX-2849","properties":[{"key":"EntryName","value":"CCR4-NOT mRNA deadenylase complex, CNOT6-CNOT8 variant"}]},{"database":"ComplexPortal","id":"CPX-707","properties":[{"key":"EntryName","value":"CCR4-NOT mRNA deadenylase complex, CNOT6-CNOT7 variant"}]},{"database":"CORUM","id":"Q9ULM6","properties":[{"key":"Description","value":"-"}]},{"database":"DIP","id":"DIP-46838N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q9ULM6","properties":[{"key":"Number of interactors","value":"3032"}]},{"database":"IntAct","id":"Q9ULM6","properties":[{"key":"Interactions","value":"44"}]},{"database":"NDEx","id":"IQUERY-CP-CNOT6","properties":[{"key":"Evidences","value":"3 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000481893","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL3616363","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"Q9ULM6","properties":[{"key":"glycosylation","value":"1 site, 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"Q9ULM6","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q9ULM6","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"CNOT6","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"46396033","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q9ULM6","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q9ULM6","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000481893","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q9ULM6","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"85079","properties":[{"key":"Description","value":"-"}]},{"database":"Pumba","id":"Q9ULM6","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"29603","properties":[{"key":"antibodies","value":"148 antibodies from 24 providers"}]},{"database":"DNASU","id":"57472","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000261951.9","properties":[{"key":"ProteinId","value":"ENSP00000261951.4"},{"key":"GeneId","value":"ENSG00000113300.14"}]},{"database":"Ensembl","id":"ENST00000393356.7","properties":[{"key":"ProteinId","value":"ENSP00000377024.1"},{"key":"GeneId","value":"ENSG00000113300.14"}]},{"database":"Ensembl","id":"ENST00000618123.4","properties":[{"key":"ProteinId","value":"ENSP00000481893.1"},{"key":"GeneId","value":"ENSG00000113300.14"}]},{"database":"Ensembl","id":"ENST00000968018.1","properties":[{"key":"ProteinId","value":"ENSP00000638077.1"},{"key":"GeneId","value":"ENSG00000113300.14"}]},{"database":"GeneID","id":"57472","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:57472","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000261951.9","properties":[{"key":"ProteinId","value":"ENSP00000261951.4"},{"key":"RefSeqNucleotideId","value":"NM_001370472.1"},{"key":"RefSeqProteinId","value":"NP_001357401.1"}]},{"database":"UCSC","id":"uc003mlx.3","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:14099","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA26677","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"57472","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"CNOT6","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:14099","properties":[{"key":"GeneName","value":"CNOT6"}]},{"database":"HPA","id":"ENSG00000113300","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MIM","id":"608951","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000113300","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000113300","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG0620","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000158978","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_016428_4_2_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q9ULM6","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"EHRMVAP","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"428734at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q9ULM6","properties":[{"key":"Number of GO annotations","value":"1 GO annotation based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q9ULM6","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q9ULM6","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-429947","properties":[{"key":"PathwayName","value":"Deadenylation of mRNA"}]},{"database":"Reactome","id":"R-HSA-5617472","properties":[{"key":"PathwayName","value":"Activation of anterior HOX genes in hindbrain development during early embryogenesis"}]},{"database":"Reactome","id":"R-HSA-6804115","properties":[{"key":"PathwayName","value":"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"}]},{"database":"Reactome","id":"R-HSA-9820841","properties":[{"key":"PathwayName","value":"M-decay: degradation of maternal mRNAs by maternally stored factors"}]},{"database":"SignaLink","id":"Q9ULM6","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"Q9ULM6","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000113300","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"57472","properties":[{"key":"hits","value":"21 hits in 1159 CRISPR screens"}]},{"database":"CD-CODE","id":"232F8A39","properties":[{"key":"EntryName","value":"P-body"}]},{"database":"CD-CODE","id":"DEE660B4","properties":[{"key":"EntryName","value":"Stress granule"}]},{"database":"ChiTaRS","id":"CNOT6","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GeneWiki","id":"CNOT6","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"57472","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q9ULM6","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:Q9ULM6","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 5"}]},{"database":"RNAct","id":"Q9ULM6","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000113300","properties":[{"key":"ExpressionPatterns","value":"Expressed in secondary oocyte and 202 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q9ULM6","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0030014","properties":[{"key":"GoTerm","value":"C:CCR4-NOT complex"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19558367"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"19946888"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0000175","properties":[{"key":"GoTerm","value":"F:3'-5'-RNA exonuclease activity"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0004535","properties":[{"key":"GoTerm","value":"F:poly(A)-specific ribonuclease activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11889047"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18377426"}]},{"database":"GO","id":"GO:0004532","properties":[{"key":"GoTerm","value":"F:RNA exonuclease activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11889047"}]},{"database":"GO","id":"GO:0003713","properties":[{"key":"GoTerm","value":"F:transcription coactivator activity"},{"key":"GoEvidenceType","value":"IDA:GO_Central"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18180299"}]},{"database":"GO","id":"GO:0035279","properties":[{"key":"GoTerm","value":"P:miRNA-mediated gene silencing by mRNA destabilization"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20065043"}]},{"database":"GO","id":"GO:0070966","properties":[{"key":"GoTerm","value":"P:nuclear-transcribed mRNA catabolic process, no-go decay"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"15314026"}]},{"database":"GO","id":"GO:0000289","properties":[{"key":"GoTerm","value":"P:nuclear-transcribed mRNA poly(A) tail shortening"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"20595389"}]},{"database":"GO","id":"GO:0008284","properties":[{"key":"GoTerm","value":"P:positive regulation of cell population proliferation"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"21233283"}]},{"database":"GO","id":"GO:0010606","properties":[{"key":"GoTerm","value":"P:positive regulation of cytoplasmic mRNA processing body assembly"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"21233283"}]},{"database":"CDD","id":"cd10313","properties":[{"key":"EntryName","value":"Deadenylase_CCR4a"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.60.10.10:FF:000002","properties":[{"key":"EntryName","value":"CCR4-NOT transcription complex subunit 6 like"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.80.10.10:FF:000008","properties":[{"key":"EntryName","value":"CCR4-NOT transcription complex subunit 6 like"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.60.10.10","properties":[{"key":"EntryName","value":"Endonuclease/exonuclease/phosphatase"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.80.10.10","properties":[{"key":"EntryName","value":"Ribonuclease Inhibitor"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR050410","properties":[{"key":"EntryName","value":"CCR4/nocturin_mRNA_transcr"}]},{"database":"InterPro","id":"IPR034966","properties":[{"key":"EntryName","value":"Cnot6"}]},{"database":"InterPro","id":"IPR036691","properties":[{"key":"EntryName","value":"Endo/exonu/phosph_ase_sf"}]},{"database":"InterPro","id":"IPR005135","properties":[{"key":"EntryName","value":"Endo/exonuclease/phosphatase"}]},{"database":"InterPro","id":"IPR001611","properties":[{"key":"EntryName","value":"Leu-rich_rpt"}]},{"database":"InterPro","id":"IPR003591","properties":[{"key":"EntryName","value":"Leu-rich_rpt_typical-subtyp"}]},{"database":"InterPro","id":"IPR032675","properties":[{"key":"EntryName","value":"LRR_dom_sf"}]},{"database":"PANTHER","id":"PTHR12121","properties":[{"key":"EntryName","value":"CARBON CATABOLITE REPRESSOR PROTEIN 4"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR12121:SF33","properties":[{"key":"EntryName","value":"CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 6"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF03372","properties":[{"key":"EntryName","value":"Exo_endo_phos"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF13855","properties":[{"key":"EntryName","value":"LRR_8"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00369","properties":[{"key":"EntryName","value":"LRR_TYP"},{"key":"MatchStatus","value":"3"}]},{"database":"SUPFAM","id":"SSF56219","properties":[{"key":"EntryName","value":"DNase I-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52058","properties":[{"key":"EntryName","value":"L domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51450","properties":[{"key":"EntryName","value":"LRR"},{"key":"MatchStatus","value":"4"}]}],"sequence":{"value":"MPKEKYEPPDPRRMYTIMSSEEAANGKKSHWAELEISGKVRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLRELHLNNNLLRVLPFELGKLFQLQTLGLKGNPLTQDILNLYQEPDGTRRLLNYLLDNLSGTAKRITTEQPPPRSWIMLQEPDRTRPTALFSVMCYNVLCDKYATRQLYGYCPSWALNWDYRKKAIIQEILSCNADIVSLQEVETEQYYSFFLVELKERGYNGFFSPKSRARTMSEQERKHVDGCAIFFKTEKFTLVQKHTVEFNQLAMANSEGSEAMLNRVMTKDNIGVAVLLELRKESIEMPSGKPHLGTEKQLILVANAHMHWDPEYSDVKLVQTMMFLSEVKNIIDKASRNLKSSVLGEFGTIPLVLCADLNSLPDSGVVEYLSTGGVETNHKDFKELRYNESLTNFSCHGKNGTTNGRITHGFKLQSAYESGLMPYTNYTFDFKGIIDYIFYSKPQLNTLGILGPLDHHWLVENNISGCPHPLIPSDHFSLFAQLELLLPFLPQVNGIHLPGRR","length":557,"molWeight":63307,"crc64":"DA9FF7A059BFB583","md5":"7D9E564991FF54BA962D76F9EC33CE5C"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"COFACTOR":1,"SUBUNIT":1,"INTERACTION":7,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Repeat":4,"Region":1,"Active site":1,"Binding site":9,"Mutagenesis":1,"Helix":21,"Beta strand":21,"Turn":5},"uniParcId":"UPI000013D22B"}},{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P51679","secondaryAccessions":["Q9ULY6","Q9ULY7"],"uniProtkbId":"CCR4_HUMAN","entryAudit":{"firstPublicDate":"1996-10-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1996-10-01","entryVersion":199,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"C-C chemokine receptor type 4"},"shortNames":[{"value":"C-C CKR-4"},{"value":"CC-CKR-4"},{"value":"CCR-4"},{"value":"CCR4"}]},"alternativeNames":[{"fullName":{"value":"K5-5"}}],"cdAntigenNames":[{"value":"CD194"}]},"genes":[{"geneName":{"value":"CCR4"},"synonyms":[{"value":"CMKBR4"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10466728"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10754297"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16137713"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9169480"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9430724"}],"value":"High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival"}],"commentType":"FUNCTION"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P51679","intActId":"EBI-7847466"},"interactantTwo":{"uniProtKBAccession":"Q92583","geneName":"CCL17","intActId":"EBI-16640146"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P51679","intActId":"EBI-7847466"},"interactantTwo":{"uniProtKBAccession":"O60894","geneName":"RAMP1","intActId":"EBI-962893"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P51679","intActId":"EBI-7847466"},"interactantTwo":{"uniProtKBAccession":"O60895","geneName":"RAMP2","intActId":"EBI-9009040"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P51679","intActId":"EBI-7847466"},"interactantTwo":{"uniProtKBAccession":"O60896","geneName":"RAMP3","intActId":"EBI-720447"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P51679","intActId":"EBI-7847466"},"interactantTwo":{"uniProtKBAccession":"A5PKU2","geneName":"TUSC5","intActId":"EBI-11988865"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"value":"Cell membrane","id":"SL-0039"},"topology":{"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10754297"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9169480"}],"value":"Predominantly expressed in the thymus, in peripheral blood leukocytes, including T-cells, mostly CD4+ cells, and basophils, and in platelets; at lower levels, in the spleen and in monocytes (PubMed:10754297, PubMed:9169480). Detected also in macrophages, IL-2-activated natural killer cells and skin-homing memory T-cells, mostly the ones expressing the cutaneous lymphocyte antigen (CLA). Expressed in brain microvascular and coronary artery endothelial cells (PubMed:10754297)"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10754297"}],"value":"In natural killer cells, CCL22 binding induces phosphorylation on yet undefined Ser/Thr residues, most probably by beta-adrenergic receptor kinases 1 and 2"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00521"}],"value":"Belongs to the G protein-coupled receptor 1 family"}],"commentType":"SIMILARITY"},{"commentType":"WEB RESOURCE","resourceName":"Wikipedia","resourceUrl":"https://en.wikipedia.org/wiki/CC_chemokine_receptors","ftp":false,"note":"CC chemokine receptors entry"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":360,"modifier":"EXACT"}},"description":"C-C chemokine receptor type 4","featureId":"PRO_0000069245"},{"type":"Topological domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":39,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":40,"modifier":"EXACT"},"end":{"value":67,"modifier":"EXACT"}},"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":68,"modifier":"EXACT"},"end":{"value":77,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":78,"modifier":"EXACT"},"end":{"value":98,"modifier":"EXACT"}},"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":99,"modifier":"EXACT"},"end":{"value":111,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":112,"modifier":"EXACT"},"end":{"value":133,"modifier":"EXACT"}},"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":134,"modifier":"EXACT"},"end":{"value":150,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":151,"modifier":"EXACT"},"end":{"value":175,"modifier":"EXACT"}},"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":176,"modifier":"EXACT"},"end":{"value":206,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":207,"modifier":"EXACT"},"end":{"value":226,"modifier":"EXACT"}},"description":"Helical; Name=5","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":227,"modifier":"EXACT"},"end":{"value":242,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":243,"modifier":"EXACT"},"end":{"value":267,"modifier":"EXACT"}},"description":"Helical; Name=6","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":268,"modifier":"EXACT"},"end":{"value":284,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":285,"modifier":"EXACT"},"end":{"value":308,"modifier":"EXACT"}},"description":"Helical; Name=7","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":309,"modifier":"EXACT"},"end":{"value":360,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Glycosylation","location":{"start":{"value":183,"modifier":"EXACT"},"end":{"value":183,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":194,"modifier":"EXACT"},"end":{"value":194,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Disulfide bond","location":{"start":{"value":110,"modifier":"EXACT"},"end":{"value":187,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00521"}]},{"type":"Natural variant","location":{"start":{"value":130,"modifier":"EXACT"},"end":{"value":130,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11196669"}],"featureId":"VAR_010669","alternativeSequence":{"originalSequence":"L","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":178,"modifier":"EXACT"},"end":{"value":178,"modifier":"EXACT"}},"description":"in dbSNP:rs753825374","featureCrossReferences":[{"database":"dbSNP","id":"rs753825374"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11196669"}],"featureId":"VAR_010670","alternativeSequence":{"originalSequence":"C","alternativeSequences":["S"]}}],"keywords":[{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0297","category":"Molecular function","name":"G protein-coupled receptor"},{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0807","category":"Molecular function","name":"Transducer"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"7642634","citationType":"journal article","authors":["Power C.A.","Meyer A.","Nemeth K.","Bacon K.B.","Hoogewerf A.J.","Proudfoot A.E.I.","Wells T.N.C."],"citationCrossReferences":[{"database":"PubMed","id":"7642634"},{"database":"DOI","id":"10.1074/jbc.270.33.19495"}],"title":"Molecular cloning and functional expression of a novel CC chemokine receptor cDNA from a human basophilic cell line.","publicationDate":"1995","journal":"J. Biol. Chem.","firstPage":"19495","lastPage":"19500","volume":"270"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"],"referenceComments":[{"value":"Spleen","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"11196669","citationType":"journal article","authors":["Kato H.","Tsuchiya N.","Izumi S.","Miyamasu M.","Nakajima T.","Kawasaki H.","Hirai K.","Tokunaga K."],"citationCrossReferences":[{"database":"PubMed","id":"11196669"},{"database":"DOI","id":"10.1038/sj.gene.6363638"}],"title":"New variations of human CC-chemokine receptors CCR3 and CCR4.","publicationDate":"1999","journal":"Genes Immun.","firstPage":"97","lastPage":"104","volume":"1"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]","VARIANTS VAL-130 AND SER-178"]},{"referenceNumber":3,"citation":{"id":"CI-13OQC231HS3T7","citationType":"submission","authors":["Kopatz S.A.","Aronstam R.S.","Sharma S.V."],"title":"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org).","publicationDate":"JUN-2003","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"]},{"referenceNumber":4,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Blood","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"9169480","citationType":"journal article","authors":["Imai T.","Baba M.","Nishimura M.","Kakizaki M.","Takagi S.","Yoshie O."],"citationCrossReferences":[{"database":"PubMed","id":"9169480"},{"database":"DOI","id":"10.1074/jbc.272.23.15036"}],"title":"The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4.","publicationDate":"1997","journal":"J. Biol. Chem.","firstPage":"15036","lastPage":"15042","volume":"272"},"referencePositions":["FUNCTION","TISSUE SPECIFICITY"]},{"referenceNumber":6,"citation":{"id":"9430724","citationType":"journal article","authors":["Imai T.","Chantry D.","Raport C.J.","Wood C.L.","Nishimura M.","Godiska R.","Yoshie O.","Gray P.W."],"citationCrossReferences":[{"database":"PubMed","id":"9430724"},{"database":"DOI","id":"10.1074/jbc.273.3.1764"}],"title":"Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4.","publicationDate":"1998","journal":"J. Biol. Chem.","firstPage":"1764","lastPage":"1768","volume":"273"},"referencePositions":["FUNCTION"]},{"referenceNumber":7,"citation":{"id":"10466728","citationType":"journal article","authors":["Campbell J.J.","Haraldsen G.","Pan J.","Rottman J.","Qin S.","Ponath P.","Andrew D.P.","Warnke R.","Ruffing N.","Kassam N.","Wu L.","Butcher E.C."],"citationCrossReferences":[{"database":"PubMed","id":"10466728"},{"database":"DOI","id":"10.1038/23495"}],"title":"The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells.","publicationDate":"1999","journal":"Nature","firstPage":"776","lastPage":"780","volume":"400"},"referencePositions":["FUNCTION"]},{"referenceNumber":8,"citation":{"id":"10754297","citationType":"journal article","authors":["Inngjerdingen M.","Damaj B.","Maghazachi A.A."],"citationCrossReferences":[{"database":"PubMed","id":"10754297"},{"database":"DOI","id":"10.4049/jimmunol.164.8.4048"}],"title":"Human NK cells express CC chemokine receptors 4 and 8 and respond to thymus and activation-regulated chemokine, macrophage-derived chemokine, and I-309.","publicationDate":"2000","journal":"J. Immunol.","firstPage":"4048","lastPage":"4054","volume":"164"},"referencePositions":["FUNCTION","TISSUE SPECIFICITY","PHOSPHORYLATION"]},{"referenceNumber":9,"citation":{"id":"16137713","citationType":"journal article","authors":["Wang Y.","Zhang Y.","Yang X.","Han W.","Liu Y.","Xu Q.","Zhao R.","Di C.","Song Q.","Ma D."],"citationCrossReferences":[{"database":"PubMed","id":"16137713"},{"database":"DOI","id":"10.1016/j.lfs.2005.05.070"}],"title":"Chemokine-like factor 1 is a functional ligand for CC chemokine receptor 4 (CCR4).","publicationDate":"2006","journal":"Life Sci.","firstPage":"614","lastPage":"621","volume":"78"},"referencePositions":["FUNCTION"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"X85740","properties":[{"key":"ProteinId","value":"CAA59743.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AB023888","properties":[{"key":"ProteinId","value":"BAA86965.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AB023889","properties":[{"key":"ProteinId","value":"BAA86966.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AB023890","properties":[{"key":"ProteinId","value":"BAA86967.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AB023891","properties":[{"key":"ProteinId","value":"BAA86968.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AB023892","properties":[{"key":"ProteinId","value":"BAA86969.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AY322539","properties":[{"key":"ProteinId","value":"AAP84352.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC069139","properties":[{"key":"ProteinId","value":"AAH69139.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC071751","properties":[{"key":"ProteinId","value":"AAH71751.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC074935","properties":[{"key":"ProteinId","value":"AAH74935.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS2656.1","properties":[{"key":"Description","value":"-"}]},{"database":"PIR","id":"A57160","properties":[{"key":"EntryName","value":"A57160"}]},{"database":"RefSeq","id":"NP_005499.1","properties":[{"key":"NucleotideSequenceId","value":"NM_005508.5"}]},{"database":"RefSeq","id":"XP_016861176.1","properties":[{"key":"NucleotideSequenceId","value":"XM_017005687.2"}]},{"database":"RefSeq","id":"XP_054201145.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054345170.1"}]},{"database":"AlphaFoldDB","id":"P51679","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-76031","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-76032","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-76035","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-76037","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-76038","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P51679","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"107638","properties":[{"key":"Interactions","value":"37"}]},{"database":"DIP","id":"DIP-5848N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P51679","properties":[{"key":"Number of interactors","value":"966"}]},{"database":"IntAct","id":"P51679","properties":[{"key":"Interactions","value":"36"}]},{"database":"MINT","id":"P51679","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-CCR4","properties":[{"key":"Evidences","value":"7 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000332659","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"P51679","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL2414","properties":[{"key":"Description","value":"-"}]},{"database":"DrugBank","id":"DB15570","properties":[{"key":"GenericName","value":"FLX475"}]},{"database":"DrugBank","id":"DB12498","properties":[{"key":"GenericName","value":"Mogamulizumab"}]},{"database":"DrugCentral","id":"P51679","properties":[{"key":"Description","value":"-"}]},{"database":"GuidetoPHARMACOLOGY","id":"61","properties":[{"key":"Description","value":"-"}]},{"database":"GlyCosmos","id":"P51679","properties":[{"key":"glycosylation","value":"2 sites, No reported glycans"}]},{"database":"GlyGen","id":"P51679","properties":[{"key":"glycosylation","value":"2 sites"}]},{"database":"iPTMnet","id":"P51679","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"P51679","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"CCR4","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"1705894","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"P51679","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000332659","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P51679","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"56366","properties":[{"key":"Description","value":"-"}]},{"database":"ABCD","id":"P51679","properties":[{"key":"antibodies","value":"1 sequenced antibody"}]},{"database":"Antibodypedia","id":"11668","properties":[{"key":"antibodies","value":"805 antibodies from 42 providers"}]},{"database":"DNASU","id":"1233","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000330953.6","properties":[{"key":"ProteinId","value":"ENSP00000332659.5"},{"key":"GeneId","value":"ENSG00000183813.8"}]},{"database":"Ensembl","id":"ENST00000718415.1","properties":[{"key":"ProteinId","value":"ENSP00000520802.1"},{"key":"GeneId","value":"ENSG00000183813.8"}]},{"database":"GeneID","id":"1233","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:1233","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000330953.6","properties":[{"key":"ProteinId","value":"ENSP00000332659.5"},{"key":"RefSeqNucleotideId","value":"NM_005508.5"},{"key":"RefSeqProteinId","value":"NP_005499.1"}]},{"database":"UCSC","id":"uc003cfg.2","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:1605","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA26169","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"1233","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"1233","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"CCR4","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:1605","properties":[{"key":"GeneName","value":"CCR4"}]},{"database":"HPA","id":"ENSG00000183813","properties":[{"key":"ExpressionPatterns","value":"Tissue enhanced (lymphoid tissue, urinary bladder)"}]},{"database":"MIM","id":"604836","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000183813","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000183813","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG3656","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT01020000230359","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_009579_8_3_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P51679","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"CKIISWM","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"5981253at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"P51679","properties":[{"key":"Number of GO annotations","value":"7 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"P51679","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"P51679","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-380108","properties":[{"key":"PathwayName","value":"Chemokine receptors bind chemokines"}]},{"database":"Reactome","id":"R-HSA-418594","properties":[{"key":"PathwayName","value":"G alpha (i) signalling events"}]},{"database":"SignaLink","id":"P51679","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"P51679","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000183813","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"1233","properties":[{"key":"hits","value":"11 hits in 1146 CRISPR screens"}]},{"database":"CD-CODE","id":"DEE660B4","properties":[{"key":"EntryName","value":"Stress granule"}]},{"database":"GeneWiki","id":"CCR4","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"1233","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"P51679","properties":[{"key":"DevelopmentLevel","value":"Tclin"}]},{"database":"PRO","id":"PR:P51679","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 3"}]},{"database":"RNAct","id":"P51679","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000183813","properties":[{"key":"ExpressionPatterns","value":"Expressed in male germ line stem cell (sensu Vertebrata) in testis and 71 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"P51679","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0009897","properties":[{"key":"GoTerm","value":"C:external side of plasma membrane"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0019957","properties":[{"key":"GoTerm","value":"F:C-C chemokine binding"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0016493","properties":[{"key":"GoTerm","value":"F:C-C chemokine receptor activity"},{"key":"GoEvidenceType","value":"IDA:UniProt"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"9169480"}]},{"database":"GO","id":"GO:0004950","properties":[{"key":"GoTerm","value":"F:chemokine receptor activity"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"7642634"}]},{"database":"GO","id":"GO:0019722","properties":[{"key":"GoTerm","value":"P:calcium-mediated signaling"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0060326","properties":[{"key":"GoTerm","value":"P:cell chemotaxis"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0006935","properties":[{"key":"GoTerm","value":"P:chemotaxis"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"7642634"}]},{"database":"GO","id":"GO:0006955","properties":[{"key":"GoTerm","value":"P:immune response"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0006954","properties":[{"key":"GoTerm","value":"P:inflammatory response"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"7642634"}]},{"database":"GO","id":"GO:0007204","properties":[{"key":"GoTerm","value":"P:positive regulation of cytosolic calcium ion concentration"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"CDD","id":"cd14984","properties":[{"key":"EntryName","value":"7tmA_Chemokine_R"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.1070.10:FF:000026","properties":[{"key":"EntryName","value":"C-C chemokine receptor type 5"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1070.10","properties":[{"key":"EntryName","value":"Rhodopsin 7-helix transmembrane proteins"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR050119","properties":[{"key":"EntryName","value":"CCR1-9-like"}]},{"database":"InterPro","id":"IPR002239","properties":[{"key":"EntryName","value":"Chemokine_CCR4"}]},{"database":"InterPro","id":"IPR000355","properties":[{"key":"EntryName","value":"Chemokine_rcpt"}]},{"database":"InterPro","id":"IPR000276","properties":[{"key":"EntryName","value":"GPCR_Rhodpsn"}]},{"database":"InterPro","id":"IPR017452","properties":[{"key":"EntryName","value":"GPCR_Rhodpsn_7TM"}]},{"database":"PANTHER","id":"PTHR10489:SF608","properties":[{"key":"EntryName","value":"C-C CHEMOKINE RECEPTOR TYPE 4"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10489","properties":[{"key":"EntryName","value":"CELL ADHESION MOLECULE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00001","properties":[{"key":"EntryName","value":"7tm_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00657","properties":[{"key":"EntryName","value":"CCCHEMOKINER"}]},{"database":"PRINTS","id":"PR01109","properties":[{"key":"EntryName","value":"CHEMOKINER4"}]},{"database":"PRINTS","id":"PR00237","properties":[{"key":"EntryName","value":"GPCRRHODOPSN"}]},{"database":"SMART","id":"SM01381","properties":[{"key":"EntryName","value":"7TM_GPCR_Srsx"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF81321","properties":[{"key":"EntryName","value":"Family A G protein-coupled receptor-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00237","properties":[{"key":"EntryName","value":"G_PROTEIN_RECEP_F1_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50262","properties":[{"key":"EntryName","value":"G_PROTEIN_RECEP_F1_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MNPTDIADTTLDESIYSNYYLYESIPKPCTKEGIKAFGELFLPPLYSLVFVFGLLGNSVVVLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAADQWVFGLGLCKMISWMYLVGFYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLATWSVAVFASLPGFLFSTCYTERNHTYCKTKYSLNSTTWKVLSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEKKNKAVKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQATETLAFVHCCLNPIIYFFLGEKFRKYILQLFKTCRGLFVLCQYCGLLQIYSADTPSSSYTQSTMDHDLHDAL","length":360,"molWeight":41403,"crc64":"51EBE12AD1FAFABF","md5":"49171824B309802D11F47472F7AC77F2"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"INTERACTION":5,"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1,"PTM":1,"SIMILARITY":1,"WEB RESOURCE":1},"countByFeatureType":{"Chain":1,"Topological domain":8,"Transmembrane":7,"Glycosylation":2,"Disulfide bond":1,"Natural variant":2},"uniParcId":"UPI000002DFE9"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0N0Q1","secondaryAccessions":["A0A024R2J7"],"uniProtkbId":"A0N0Q1_HUMAN","entryAudit":{"firstPublicDate":"2006-12-12","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2006-12-12","entryVersion":148,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF85363.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"EAW64440.1"}],"value":"Chemokine (C-C motif) receptor 4, isoform CRA_a"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF85363.1"}],"value":"cDNA FLJ75821, highly similar to Homo sapiens chemokine (C-C motif) receptor 4 (CCR4), mRNA"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"EAW64440.1"}],"value":"CCR4"},"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"EAW64440.1"}],"value":"hCG_1776165"}]}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004651"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004651"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00521"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000688"}],"value":"Belongs to the G protein-coupled receptor 1 family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00521"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Transmembrane","location":{"start":{"value":45,"modifier":"EXACT"},"end":{"value":65,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":77,"modifier":"EXACT"},"end":{"value":100,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":112,"modifier":"EXACT"},"end":{"value":130,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":151,"modifier":"EXACT"},"end":{"value":174,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":200,"modifier":"EXACT"},"end":{"value":222,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":243,"modifier":"EXACT"},"end":{"value":264,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":284,"modifier":"EXACT"},"end":{"value":307,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":56,"modifier":"EXACT"},"end":{"value":304,"modifier":"EXACT"}},"description":"G-protein coupled receptors family 1 profile","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50262"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023040"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00521"}],"id":"KW-0297","category":"Molecular function","name":"G protein-coupled receptor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00521"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023170"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00521"}],"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023224"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00521"}],"id":"KW-0807","category":"Molecular function","name":"Transducer"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000688"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"11181995","citationType":"journal article","authors":["Venter J.C.","Adams M.D.","Myers E.W.","Li P.W.","Mural R.J.","Sutton G.G.","Smith H.O.","Yandell M.","Evans C.A.","Holt R.A.","Gocayne J.D.","Amanatides P.","Ballew R.M.","Huson D.H.","Wortman J.R.","Zhang Q.","Kodira C.D.","Zheng X.H.","Chen L.","Skupski M.","Subramanian G.","Thomas P.D.","Zhang J.","Gabor Miklos G.L.","Nelson C.","Broder S.","Clark A.G.","Nadeau J.","McKusick V.A.","Zinder N.","Levine A.J.","Roberts R.J.","Simon M.","Slayman C.","Hunkapiller M.","Bolanos R.","Delcher A.","Dew I.","Fasulo D.","Flanigan M.","Florea L.","Halpern A.","Hannenhalli S.","Kravitz S.","Levy S.","Mobarry C.","Reinert K.","Remington K.","Abu-Threideh J.","Beasley E.","Biddick K.","Bonazzi V.","Brandon R.","Cargill M.","Chandramouliswaran I.","Charlab R.","Chaturvedi K.","Deng Z.","Di Francesco V.","Dunn P.","Eilbeck K.","Evangelista C.","Gabrielian A.E.","Gan W.","Ge W.","Gong F.","Gu Z.","Guan P.","Heiman T.J.","Higgins M.E.","Ji R.R.","Ke Z.","Ketchum K.A.","Lai Z.","Lei Y.","Li Z.","Li J.","Liang Y.","Lin X.","Lu F.","Merkulov G.V.","Milshina N.","Moore H.M.","Naik A.K.","Narayan V.A.","Neelam B.","Nusskern D.","Rusch D.B.","Salzberg S.","Shao W.","Shue B.","Sun J.","Wang Z.","Wang A.","Wang X.","Wang J.","Wei M.","Wides R.","Xiao C.","Yan C.","Yao A.","Ye J.","Zhan M.","Zhang W.","Zhang H.","Zhao Q.","Zheng L.","Zhong F.","Zhong W.","Zhu S.","Zhao S.","Gilbert D.","Baumhueter S.","Spier G.","Carter C.","Cravchik A.","Woodage T.","Ali F.","An H.","Awe A.","Baldwin D.","Baden H.","Barnstead M.","Barrow I.","Beeson K.","Busam D.","Carver A.","Center A.","Cheng M.L.","Curry L.","Danaher S.","Davenport L.","Desilets R.","Dietz S.","Dodson K.","Doup L.","Ferriera S.","Garg N.","Gluecksmann A.","Hart B.","Haynes J.","Haynes C.","Heiner C.","Hladun S.","Hostin D.","Houck J.","Howland T.","Ibegwam C.","Johnson J.","Kalush F.","Kline L.","Koduru S.","Love A.","Mann F.","May D.","McCawley S.","McIntosh T.","McMullen I.","Moy M.","Moy L.","Murphy B.","Nelson K.","Pfannkoch C.","Pratts E.","Puri V.","Qureshi H.","Reardon M.","Rodriguez R.","Rogers Y.H.","Romblad D.","Ruhfel B.","Scott R.","Sitter C.","Smallwood M.","Stewart E.","Strong R.","Suh E.","Thomas R.","Tint N.N.","Tse S.","Vech C.","Wang G.","Wetter J.","Williams S.","Williams M.","Windsor S.","Winn-Deen E.","Wolfe K.","Zaveri J.","Zaveri K.","Abril J.F.","Guigo R.","Campbell M.J.","Sjolander K.V.","Karlak B.","Kejariwal A.","Mi H.","Lazareva B.","Hatton T.","Narechania A.","Diemer K.","Muruganujan A.","Guo N.","Sato S.","Bafna V.","Istrail S.","Lippert R.","Schwartz R.","Walenz B.","Yooseph S.","Allen D.","Basu A.","Baxendale J.","Blick L.","Caminha M.","Carnes-Stine J.","Caulk P.","Chiang Y.H.","Coyne M.","Dahlke C.","Mays A.","Dombroski M.","Donnelly M.","Ely D.","Esparham S.","Fosler C.","Gire H.","Glanowski S.","Glasser K.","Glodek A.","Gorokhov M.","Graham K.","Gropman B.","Harris M.","Heil J.","Henderson S.","Hoover J.","Jennings D.","Jordan C.","Jordan J.","Kasha J.","Kagan L.","Kraft C.","Levitsky A.","Lewis M.","Liu X.","Lopez J.","Ma D.","Majoros W.","McDaniel J.","Murphy S.","Newman M.","Nguyen T.","Nguyen N.","Nodell M.","Pan S.","Peck J.","Peterson M.","Rowe W.","Sanders R.","Scott J.","Simpson M.","Smith T.","Sprague A.","Stockwell T.","Turner R.","Venter E.","Wang M.","Wen M.","Wu D.","Wu M.","Xia A.","Zandieh A.","Zhu X."],"citationCrossReferences":[{"database":"PubMed","id":"11181995"},{"database":"DOI","id":"10.1126/science.1058040"}],"title":"The sequence of the human genome.","publicationDate":"2001","journal":"Science","firstPage":"1304","lastPage":"1351","volume":"291"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"EAW64440.1"}]},{"referenceNumber":2,"citation":{"id":"CI-56FT96O07V0QG","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"JUL-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"EAW64440.1"}]},{"referenceNumber":3,"citation":{"id":"CI-96UCQGGE2UV0L","citationType":"submission","authors":["Wakamatsu A.","Yamamoto J.","Kimura K.","Ishii S.","Watanabe K.","Sugiyama A.","Murakawa K.","Kaida T.","Tsuchiya K.","Fukuzumi Y.","Kumagai A.","Oishi Y.","Yamamoto S.","Ono Y.","Komori Y.","Yamazaki M.","Kisu Y.","Nishikawa T.","Sugano S.","Nomura N.","Isogai T."],"title":"NEDO human cDNA sequencing project.","publicationDate":"OCT-2007","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF85363.1"}],"value":"Thymus","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF85363.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AK292674","properties":[{"key":"ProteinId","value":"BAF85363.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"CH471055","properties":[{"key":"ProteinId","value":"EAW64440.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"NP_005499.1","properties":[{"key":"NucleotideSequenceId","value":"NM_005508.5"}]},{"database":"RefSeq","id":"XP_016861176.1","properties":[{"key":"NucleotideSequenceId","value":"XM_017005687.2"}]},{"database":"RefSeq","id":"XP_054201145.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054345170.1"}]},{"database":"AlphaFoldDB","id":"A0N0Q1","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0N0Q1","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"11668","properties":[{"key":"antibodies","value":"805 antibodies from 42 providers"}]},{"database":"DNASU","id":"1233","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"1233","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:1233","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA26169","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"1233","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"1233","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000183813","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_009579_8_3_1","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"CKIISWM","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"5981253at2759","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"1233","properties":[{"key":"hits","value":"11 hits in 1146 CRISPR screens"}]},{"database":"GO","id":"GO:0009897","properties":[{"key":"GoTerm","value":"C:external side of plasma membrane"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0016493","properties":[{"key":"GoTerm","value":"F:C-C chemokine receptor activity"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0006935","properties":[{"key":"GoTerm","value":"P:chemotaxis"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006955","properties":[{"key":"GoTerm","value":"P:immune response"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006954","properties":[{"key":"GoTerm","value":"P:inflammatory response"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd14984","properties":[{"key":"EntryName","value":"7tmA_Chemokine_R"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.1070.10:FF:000026","properties":[{"key":"EntryName","value":"C-C chemokine receptor type 5"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1070.10","properties":[{"key":"EntryName","value":"Rhodopsin 7-helix transmembrane proteins"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR050119","properties":[{"key":"EntryName","value":"CCR1-9-like"}]},{"database":"InterPro","id":"IPR002239","properties":[{"key":"EntryName","value":"Chemokine_CCR4"}]},{"database":"InterPro","id":"IPR000355","properties":[{"key":"EntryName","value":"Chemokine_rcpt"}]},{"database":"InterPro","id":"IPR000276","properties":[{"key":"EntryName","value":"GPCR_Rhodpsn"}]},{"database":"InterPro","id":"IPR017452","properties":[{"key":"EntryName","value":"GPCR_Rhodpsn_7TM"}]},{"database":"PANTHER","id":"PTHR10489:SF608","properties":[{"key":"EntryName","value":"C-C CHEMOKINE RECEPTOR TYPE 4"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10489","properties":[{"key":"EntryName","value":"CELL ADHESION MOLECULE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00001","properties":[{"key":"EntryName","value":"7tm_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00657","properties":[{"key":"EntryName","value":"CCCHEMOKINER"}]},{"database":"PRINTS","id":"PR01109","properties":[{"key":"EntryName","value":"CHEMOKINER4"}]},{"database":"PRINTS","id":"PR00237","properties":[{"key":"EntryName","value":"GPCRRHODOPSN"}]},{"database":"SMART","id":"SM01381","properties":[{"key":"EntryName","value":"7TM_GPCR_Srsx"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF81321","properties":[{"key":"EntryName","value":"Family A G protein-coupled receptor-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00237","properties":[{"key":"EntryName","value":"G_PROTEIN_RECEP_F1_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50262","properties":[{"key":"EntryName","value":"G_PROTEIN_RECEP_F1_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MNPTDIADTTLDESIYSNYYLYESIPKPCTKEGIKAFGELFLPPLYSLVFVFGLLGNSVVVLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAADQWVFGLGLCKMISWMYLVGFYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLATWSVAVFASLPGFLFSTCYTERNHTYCKTKYSLNSTTWKVLSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEKKNKAVKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQATETLAFVHCCLNPIIYFFLGEKFRKYILQLFKTCRGLFVLCQYCGLLQIYSADTPSSSYTQSTMDHDLHDAL","length":360,"molWeight":41403,"crc64":"51EBE12AD1FAFABF","md5":"49171824B309802D11F47472F7AC77F2"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Transmembrane":7,"Domain":1},"uniParcId":"UPI000002DFE9"}}]}