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Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B (By similarity). Mediates the recruitment of macrophages and monocytes to the injury site following brain injury (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9789057"}],"value":"(Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15995708"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23938203"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25283965"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35570218"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9501202"}],"value":"Interacts with ARRB1 (PubMed:9501202). 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