{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"O00622","secondaryAccessions":["O14934","O43775","Q9BZL7"],"uniProtkbId":"CCN1_HUMAN","entryAudit":{"firstPublicDate":"1998-07-15","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1997-07-01","entryVersion":211,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"CCN family member 1"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:2654"}],"value":"Cellular communication network factor 1"}},{"fullName":{"value":"Cysteine-rich angiogenic inducer 61"}},{"fullName":{"value":"Insulin-like growth factor-binding protein 10"},"shortNames":[{"value":"IBP-10"},{"value":"IGF-binding protein 10"},{"value":"IGFBP-10"}]},{"fullName":{"value":"Protein CYR61"}},{"fullName":{"value":"Protein GIG1"}}],"flag":"Precursor"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:2654"}],"value":"CCN1"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"9135077"}],"value":"CYR61"},{"value":"GIG1"},{"value":"IGFBP10"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11584015"}],"value":"Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CCN1-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10446209"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10821835"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11287419"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9446626"}],"value":"Interaction with integrins is heparin- and cell-type-dependent and promotes cell adhesion. In skin fibroblasts it binds ITGA6/ITGB1, in endothelial cells, binds ITGAV/ITGB3 and in platelets, ITGA2B/ITGB3. Binds, in vitro, ITGAV/ITGB5"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"O00622","intActId":"EBI-1237454"},"interactantTwo":{"uniProtKBAccession":"O60906","geneName":"SMPD2","intActId":"EBI-12828299"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O00622","intActId":"EBI-1237454"},"interactantTwo":{"uniProtKBAccession":"Q9UHD9","geneName":"UBQLN2","intActId":"EBI-947187"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the CCN family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":24,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Chain","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":381,"modifier":"EXACT"}},"description":"CCN family member 1","featureId":"PRO_0000014398"},{"type":"Domain","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":94,"modifier":"EXACT"}},"description":"IGFBP N-terminal","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00653"}]},{"type":"Domain","location":{"start":{"value":98,"modifier":"EXACT"},"end":{"value":164,"modifier":"EXACT"}},"description":"VWFC","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00220"}]},{"type":"Domain","location":{"start":{"value":228,"modifier":"EXACT"},"end":{"value":273,"modifier":"EXACT"}},"description":"TSP type-1","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00210"}]},{"type":"Domain","location":{"start":{"value":286,"modifier":"EXACT"},"end":{"value":360,"modifier":"EXACT"}},"description":"CTCK","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00039"}]},{"type":"Region","location":{"start":{"value":279,"modifier":"EXACT"},"end":{"value":315,"modifier":"EXACT"}},"description":"Heparin-binding","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P18406"}]},{"type":"Modified residue","location":{"start":{"value":188,"modifier":"EXACT"},"end":{"value":188,"modifier":"EXACT"}},"description":"Phosphoserine; by FAM20C","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26091039"}]},{"type":"Disulfide bond","location":{"start":{"value":26,"modifier":"EXACT"},"end":{"value":50,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00653"}]},{"type":"Disulfide bond","location":{"start":{"value":30,"modifier":"EXACT"},"end":{"value":52,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00653"}]},{"type":"Disulfide bond","location":{"start":{"value":32,"modifier":"EXACT"},"end":{"value":53,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00653"}]},{"type":"Disulfide bond","location":{"start":{"value":39,"modifier":"EXACT"},"end":{"value":56,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00653"}]},{"type":"Disulfide bond","location":{"start":{"value":64,"modifier":"EXACT"},"end":{"value":78,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00653"}]},{"type":"Disulfide bond","location":{"start":{"value":70,"modifier":"EXACT"},"end":{"value":91,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00653"}]},{"type":"Disulfide bond","location":{"start":{"value":286,"modifier":"EXACT"},"end":{"value":323,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Disulfide bond","location":{"start":{"value":303,"modifier":"EXACT"},"end":{"value":337,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Disulfide bond","location":{"start":{"value":314,"modifier":"EXACT"},"end":{"value":353,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Disulfide bond","location":{"start":{"value":317,"modifier":"EXACT"},"end":{"value":355,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Disulfide bond","location":{"start":{"value":322,"modifier":"EXACT"},"end":{"value":359,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Natural variant","location":{"start":{"value":334,"modifier":"EXACT"},"end":{"value":334,"modifier":"EXACT"}},"description":"in dbSNP:rs9658587","featureCrossReferences":[{"database":"dbSNP","id":"rs9658587"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.8"}],"featureId":"VAR_018934","alternativeSequence":{"originalSequence":"R","alternativeSequences":["W"]}},{"type":"Sequence conflict","location":{"start":{"value":165,"modifier":"EXACT"},"end":{"value":165,"modifier":"EXACT"}},"description":"in Ref. 2; CAA72167","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["Q"]}},{"type":"Sequence conflict","location":{"start":{"value":210,"modifier":"EXACT"},"end":{"value":210,"modifier":"EXACT"}},"description":"in Ref. 5; AAB84227","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"L","alternativeSequences":["I"]}},{"type":"Sequence conflict","location":{"start":{"value":220,"modifier":"EXACT"},"end":{"value":220,"modifier":"EXACT"}},"description":"in Ref. 5; AAB84227","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"L","alternativeSequences":["R"]}},{"type":"Sequence conflict","location":{"start":{"value":369,"modifier":"EXACT"},"end":{"value":369,"modifier":"EXACT"}},"description":"in Ref. 7; AAG59863","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"F","alternativeSequences":["L"]}},{"type":"Helix","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":27,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4D0Z"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0130","category":"Biological process","name":"Cell adhesion"},{"id":"KW-0145","category":"Biological process","name":"Chemotaxis"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0340","category":"Molecular function","name":"Growth factor binding"},{"id":"KW-0358","category":"Molecular function","name":"Heparin-binding"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"9135077","citationType":"journal article","authors":["Jay P.","Berge-Lefranc J.-L.","Marsollier C.","Mejean C.","Taviaux S.","Berta P."],"citationCrossReferences":[{"database":"PubMed","id":"9135077"},{"database":"DOI","id":"10.1038/sj.onc.1200986"}],"title":"The human growth factor-inducible immediate early gene, CYR61, maps to chromosome 1p.","publicationDate":"1997","journal":"Oncogene","firstPage":"1753","lastPage":"1757","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"]},{"referenceNumber":2,"citation":{"id":"9536281","citationType":"journal article","authors":["Martinerie C.","Viegas-Pequignot E.","Nguyen V.C.","Perbal B."],"citationCrossReferences":[{"database":"PubMed","id":"9536281"},{"database":"DOI","id":"10.1136/mp.50.6.310"}],"title":"Chromosomal mapping and expression of the human cyr61 gene in tumour cells from the nervous system.","publicationDate":"1997","journal":"Mol. Pathol.","firstPage":"310","lastPage":"316","volume":"50"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"]},{"referenceNumber":3,"citation":{"id":"10852911","citationType":"journal article","authors":["Albrecht C.","von Der Kammer H.","Mayhaus M.","Klaudiny J.","Schweizer M.","Nitsch R.M."],"citationCrossReferences":[{"database":"PubMed","id":"10852911"},{"database":"DOI","id":"10.1074/jbc.m003053200"}],"title":"Muscarinic acetylcholine receptors induce the expression of the immediate early growth regulatory gene CYR61.","publicationDate":"2000","journal":"J. Biol. Chem.","firstPage":"28929","lastPage":"28936","volume":"275"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"]},{"referenceNumber":4,"citation":{"id":"CI-C1MFFKAF65GRI","citationType":"submission","authors":["Kolesnikova T.V.","Lau L.F."],"title":"Human growth-factor inducible gene product CYR61, complete sequence.","publicationDate":"JUN-1997","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"],"referenceComments":[{"value":"Placenta","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"CI-9GM0A07K5D2LM","citationType":"submission","authors":["Bi A.B.","Yu L."],"title":"Cloning of HumCyr61 gene expressing down-regulatedly in rhabdomyosarcoma.","publicationDate":"NOV-1997","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"]},{"referenceNumber":6,"citation":{"id":"CI-7HTP5ER3QDPN8","citationType":"submission","authors":["Schuetze N.","Lechner A.","Groll C.","Koehrle J.","Jakob F."],"title":"Regulation of hCYR61 by vitamin D, serum and cytokines in fetal human osteoblasts.","publicationDate":"JUL-1997","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"]},{"referenceNumber":7,"citation":{"id":"11810026","citationType":"journal article","authors":["Leng E.","Malcolm T.","Tai G.","Estable M.","Sadowski I."],"citationCrossReferences":[{"database":"PubMed","id":"11810026"},{"database":"DOI","id":"10.1007/bf02256579"}],"title":"Organization and expression of the Cyr61 gene in normal human fibroblasts.","publicationDate":"2002","journal":"J. Biomed. Sci.","firstPage":"59","lastPage":"67","volume":"9"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":8,"citation":{"id":"CI-9GALKN8DBTP2G","citationType":"submission","authoringGroup":["NIEHS SNPs program"],"publicationDate":"OCT-2003","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]","VARIANT TRP-334"]},{"referenceNumber":9,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Lung","type":"TISSUE"},{"value":"Placenta","type":"TISSUE"},{"value":"Skin","type":"TISSUE"}]},{"referenceNumber":10,"citation":{"id":"11584015","citationType":"journal article","authors":["Chen C.-C.","Mo F.-E.","Lau L.F."],"citationCrossReferences":[{"database":"PubMed","id":"11584015"},{"database":"DOI","id":"10.1074/jbc.m107666200"}],"title":"The angiogenic factor Cyr61 activates a genetic program for wound healing in human skin fibroblasts.","publicationDate":"2001","journal":"J. Biol. Chem.","firstPage":"47329","lastPage":"47337","volume":"276"},"referencePositions":["FUNCTION IN WOUND HEALING"]},{"referenceNumber":11,"citation":{"id":"9446626","citationType":"journal article","authors":["Kireeva M.L.","Lam S.C.","Lau L.F."],"citationCrossReferences":[{"database":"PubMed","id":"9446626"},{"database":"DOI","id":"10.1074/jbc.273.5.3090"}],"title":"Adhesion of human umbilical vein endothelial cells to the immediate-early gene product Cyr61 is mediated through integrin alphavbeta3.","publicationDate":"1998","journal":"J. Biol. Chem.","firstPage":"3090","lastPage":"3096","volume":"273"},"referencePositions":["INTERACTION WITH INTEGRIN ALPHA-V/BETA-3"]},{"referenceNumber":12,"citation":{"id":"10446209","citationType":"journal article","authors":["Jedsadayanmata A.","Chen C.-C.","Kireeva M.L.","Lau L.F.","Lam S.C."],"citationCrossReferences":[{"database":"PubMed","id":"10446209"},{"database":"DOI","id":"10.1074/jbc.274.34.24321"}],"title":"Activation-dependent adhesion of human platelets to Cyr61 and Fisp12/mouse connective tissue growth factor is mediated through integrin alpha(IIb)beta(3).","publicationDate":"1999","journal":"J. Biol. Chem.","firstPage":"24321","lastPage":"24327","volume":"274"},"referencePositions":["INTERACTION WITH INTEGRIN ALPHA-IIB/BETA-3"]},{"referenceNumber":13,"citation":{"id":"10821835","citationType":"journal article","authors":["Chen N.","Chen C.-C.","Lau L.F."],"citationCrossReferences":[{"database":"PubMed","id":"10821835"},{"database":"DOI","id":"10.1074/jbc.m003040200"}],"title":"Adhesion of human skin fibroblasts to Cyr61 is mediated through integrin alpha 6beta 1 and cell surface heparan sulfate proteoglycans.","publicationDate":"2000","journal":"J. Biol. Chem.","firstPage":"24953","lastPage":"24961","volume":"275"},"referencePositions":["INTERACTION WITH INTEGRIN ALPHA-6/BETA-1"]},{"referenceNumber":14,"citation":{"id":"11287419","citationType":"journal article","authors":["Grzeszkiewicz T.M.","Kirschling D.J.","Chen N.","Lau L.F."],"citationCrossReferences":[{"database":"PubMed","id":"11287419"},{"database":"DOI","id":"10.1074/jbc.m100978200"}],"title":"CYR61 stimulates human skin fibroblast migration through Integrin alpha vbeta 5 and enhances mitogenesis through integrin alpha vbeta 3, independent of its carboxyl-terminal domain.","publicationDate":"2001","journal":"J. Biol. Chem.","firstPage":"21943","lastPage":"21950","volume":"276"},"referencePositions":["INTERACTION WITH INTEGRIN ALPHA-V/BETA-6"]},{"referenceNumber":15,"citation":{"id":"26091039","citationType":"journal article","authors":["Tagliabracci V.S.","Wiley S.E.","Guo X.","Kinch L.N.","Durrant E.","Wen J.","Xiao J.","Cui J.","Nguyen K.B.","Engel J.L.","Coon J.J.","Grishin N.","Pinna L.A.","Pagliarini D.J.","Dixon J.E."],"citationCrossReferences":[{"database":"PubMed","id":"26091039"},{"database":"DOI","id":"10.1016/j.cell.2015.05.028"}],"title":"A single kinase generates the majority of the secreted phosphoproteome.","publicationDate":"2015","journal":"Cell","firstPage":"1619","lastPage":"1632","volume":"161"},"referencePositions":["PHOSPHORYLATION AT SER-188"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"U62015","properties":[{"key":"ProteinId","value":"AAB58319.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"Y11307","properties":[{"key":"ProteinId","value":"CAA72167.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"Y12084","properties":[{"key":"ProteinId","value":"CAA72802.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF003594","properties":[{"key":"ProteinId","value":"AAB61240.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF031385","properties":[{"key":"ProteinId","value":"AAB84227.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"Z98053","properties":[{"key":"ProteinId","value":"CAB10848.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF307860","properties":[{"key":"ProteinId","value":"AAG59863.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AY443495","properties":[{"key":"ProteinId","value":"AAR05446.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC001271","properties":[{"key":"ProteinId","value":"AAH01271.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC009199","properties":[{"key":"ProteinId","value":"AAH09199.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC016952","properties":[{"key":"ProteinId","value":"AAH16952.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS706.1","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_001545.2","properties":[{"key":"NucleotideSequenceId","value":"NM_001554.5"}]},{"database":"PDB","id":"4D0Z","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.20 A"},{"key":"Chains","value":"X/Y=24-29"}]},{"database":"PDB","id":"4D11","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.85 A"},{"key":"Chains","value":"L/O/P/X/Z=24-29"}]},{"database":"PDBsum","id":"4D0Z","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4D11","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"O00622","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"O00622","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"109712","properties":[{"key":"Interactions","value":"51"}]},{"database":"CORUM","id":"O00622","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"O00622","properties":[{"key":"Number of interactors","value":"211"}]},{"database":"IntAct","id":"O00622","properties":[{"key":"Interactions","value":"22"}]},{"database":"MINT","id":"O00622","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-CCN1","properties":[{"key":"Evidences","value":"1 NDEx IQuery Curated Pathway"}]},{"database":"STRING","id":"9606.ENSP00000398736","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"O00622","properties":[{"key":"glycosylation","value":"2 sites, 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"O00622","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"O00622","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"CYR61","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"O00622","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"O00622","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000398736","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"O00622","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"47995","properties":[{"key":"Description","value":"-"}]},{"database":"Pumba","id":"O00622","properties":[{"key":"Description","value":"-"}]},{"database":"ABCD","id":"O00622","properties":[{"key":"antibodies","value":"1 sequenced antibody"}]},{"database":"Antibodypedia","id":"19796","properties":[{"key":"antibodies","value":"609 antibodies from 39 providers"}]},{"database":"DNASU","id":"3491","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000451137.7","properties":[{"key":"ProteinId","value":"ENSP00000398736.2"},{"key":"GeneId","value":"ENSG00000142871.19"}]},{"database":"GeneID","id":"3491","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:3491","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000451137.7","properties":[{"key":"ProteinId","value":"ENSP00000398736.2"},{"key":"RefSeqNucleotideId","value":"NM_001554.5"},{"key":"RefSeqProteinId","value":"NP_001545.2"}]},{"database":"AGR","id":"HGNC:2654","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA27126","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"3491","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"3491","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"CCN1","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:2654","properties":[{"key":"GeneName","value":"CCN1"}]},{"database":"HPA","id":"ENSG00000142871","properties":[{"key":"ExpressionPatterns","value":"Tissue enhanced (blood)"}]},{"database":"MIM","id":"602369","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000142871","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000142871","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502QQQQ","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000155151","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_063247_1_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"O00622","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"HCDDGET","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"365605at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"O00622","properties":[{"key":"Number of GO annotations","value":"8 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"O00622","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"O00622","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-381426","properties":[{"key":"PathwayName","value":"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"}]},{"database":"Reactome","id":"R-HSA-8957275","properties":[{"key":"PathwayName","value":"Post-translational protein phosphorylation"}]},{"database":"SignaLink","id":"O00622","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000142871","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"3491","properties":[{"key":"hits","value":"11 hits in 1161 CRISPR screens"}]},{"database":"ChiTaRS","id":"CYR61","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GeneWiki","id":"CYR61","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"3491","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"O00622","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:O00622","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"RNAct","id":"O00622","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000142871","properties":[{"key":"ExpressionPatterns","value":"Expressed in left uterine tube and 206 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"O00622","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005788","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum lumen"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0031012","properties":[{"key":"GoTerm","value":"C:extracellular matrix"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"23658023"}]},{"database":"GO","id":"GO:0140149","properties":[{"key":"GoTerm","value":"C:non-collagenous component of interstitial matrix"},{"key":"GoEvidenceType","value":"IDA:GO_Central"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"23825719"}]},{"database":"GO","id":"GO:0050840","properties":[{"key":"GoTerm","value":"F:extracellular matrix binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0008201","properties":[{"key":"GoTerm","value":"F:heparin binding"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0005178","properties":[{"key":"GoTerm","value":"F:integrin binding"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0007155","properties":[{"key":"GoTerm","value":"P:cell adhesion"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0007229","properties":[{"key":"GoTerm","value":"P:integrin-mediated signaling pathway"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20675382"}]},{"database":"GO","id":"GO:0030513","properties":[{"key":"GoTerm","value":"P:positive regulation of BMP signaling pathway"},{"key":"GoEvidenceType","value":"IGI:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"20675382"}]},{"database":"GO","id":"GO:0030501","properties":[{"key":"GoTerm","value":"P:positive regulation of bone mineralization"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20675382"}]},{"database":"GO","id":"GO:0045597","properties":[{"key":"GoTerm","value":"P:positive regulation of cell differentiation"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0030335","properties":[{"key":"GoTerm","value":"P:positive regulation of cell migration"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20675382"}]},{"database":"GO","id":"GO:0045669","properties":[{"key":"GoTerm","value":"P:positive regulation of osteoblast differentiation"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20675382"}]},{"database":"GO","id":"GO:0033690","properties":[{"key":"GoTerm","value":"P:positive regulation of osteoblast proliferation"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20675382"}]},{"database":"GO","id":"GO:0045944","properties":[{"key":"GoTerm","value":"P:positive regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20675382"}]},{"database":"GO","id":"GO:0070372","properties":[{"key":"GoTerm","value":"P:regulation of ERK1 and ERK2 cascade"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20675382"}]},{"database":"GO","id":"GO:0007165","properties":[{"key":"GoTerm","value":"P:signal transduction"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"FunFam","id":"2.10.70.10:FF:000015","properties":[{"key":"EntryName","value":"CYR61 isoform 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.20.100.10:FF:000038","properties":[{"key":"EntryName","value":"CYR61 isoform 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.10.70.10","properties":[{"key":"EntryName","value":"Complement Module, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.20.100.10","properties":[{"key":"EntryName","value":"Thrombospondin type-1 (TSP1) repeat"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR050941","properties":[{"key":"EntryName","value":"CCN"}]},{"database":"InterPro","id":"IPR006207","properties":[{"key":"EntryName","value":"Cys_knot_C"}]},{"database":"InterPro","id":"IPR006208","properties":[{"key":"EntryName","value":"Glyco_hormone_CN"}]},{"database":"InterPro","id":"IPR009030","properties":[{"key":"EntryName","value":"Growth_fac_rcpt_cys_sf"}]},{"database":"InterPro","id":"IPR000867","properties":[{"key":"EntryName","value":"IGFBP-like"}]},{"database":"InterPro","id":"IPR012395","properties":[{"key":"EntryName","value":"IGFBP_CNN"}]},{"database":"InterPro","id":"IPR017891","properties":[{"key":"EntryName","value":"Insulin_GF-bd_Cys-rich_CS"}]},{"database":"InterPro","id":"IPR043973","properties":[{"key":"EntryName","value":"TSP1_CCN"}]},{"database":"InterPro","id":"IPR000884","properties":[{"key":"EntryName","value":"TSP1_rpt"}]},{"database":"InterPro","id":"IPR036383","properties":[{"key":"EntryName","value":"TSP1_rpt_sf"}]},{"database":"InterPro","id":"IPR001007","properties":[{"key":"EntryName","value":"VWF_dom"}]},{"database":"PANTHER","id":"PTHR11348:SF18","properties":[{"key":"EntryName","value":"CCN FAMILY MEMBER 1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11348","properties":[{"key":"EntryName","value":"CONNECTIVE TISSUE GROWTH FACTOR-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00007","properties":[{"key":"EntryName","value":"Cys_knot"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00219","properties":[{"key":"EntryName","value":"IGFBP"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF19035","properties":[{"key":"EntryName","value":"TSP1_CCN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00093","properties":[{"key":"EntryName","value":"VWC"},{"key":"MatchStatus","value":"1"}]},{"database":"PIRSF","id":"PIRSF036495","properties":[{"key":"EntryName","value":"IGFBP_rP_CNN"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00041","properties":[{"key":"EntryName","value":"CT"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00121","properties":[{"key":"EntryName","value":"IB"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00209","properties":[{"key":"EntryName","value":"TSP1"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00214","properties":[{"key":"EntryName","value":"VWC"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57603","properties":[{"key":"EntryName","value":"FnI-like domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57184","properties":[{"key":"EntryName","value":"Growth factor receptor domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF82895","properties":[{"key":"EntryName","value":"TSP-1 type 1 repeat"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01185","properties":[{"key":"EntryName","value":"CTCK_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01225","properties":[{"key":"EntryName","value":"CTCK_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00222","properties":[{"key":"EntryName","value":"IGFBP_N_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51323","properties":[{"key":"EntryName","value":"IGFBP_N_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50092","properties":[{"key":"EntryName","value":"TSP1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01208","properties":[{"key":"EntryName","value":"VWFC_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50184","properties":[{"key":"EntryName","value":"VWFC_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSSRIARALALVVTLLHLTRLALSTCPAACHCPLEAPKCAPGVGLVRDGCGCCKVCAKQLNEDCSKTQPCDHTKGLECNFGASSTALKGICRAQSEGRPCEYNSRIYQNGESFQPNCKHQCTCIDGAVGCIPLCPQELSLPNLGCPNPRLVKVTGQCCEEWVCDEDSIKDPMEDQDGLLGKELGFDASEVELTRNNELIAVGKGSSLKRLPVFGMEPRILYNPLQGQKCIVQTTSWSQCSKTCGTGISTRVTNDNPECRLVKETRICEVRPCGQPVYSSLKKGKKCSKTKKSPEPVRFTYAGCLSVKKYRPKYCGSCVDGRCCTPQLTRTVKMRFRCEDGETFSKNVMMIQSCKCNYNCPHANEAAFPFYRLFNDIHKFRD","length":381,"molWeight":42027,"crc64":"FC0BD39C078CA0B1","md5":"17F014C72F4A6DB07A384A7E416A537C"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"INTERACTION":2,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":4,"Region":1,"Modified residue":1,"Disulfide bond":11,"Natural variant":1,"Sequence conflict":4,"Helix":1},"uniParcId":"UPI00000473C9"}},{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P20248","secondaryAccessions":["A8K7B6","Q2M3U6","Q4W5P4","Q6LER8"],"uniProtkbId":"CCNA2_HUMAN","entryAudit":{"firstPublicDate":"1991-02-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2010-11-02","entryVersion":239,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:1578"}],"value":"Cyclin-A2"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"1967822"}],"value":"Cyclin-A"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"1967822"}],"value":"Cyclin A"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:1578"}],"value":"CCNA2"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:1578"}],"value":"CCN1"},{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:1578"}],"value":"CCNA"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1312467"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"41100585"}],"value":"Essential for the control of the cell cycle at G1/S and G2/M transition (PubMed:1312467). Functions through the formation of specific serine/threonine protein kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 or CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle (PubMed:41100585)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1312467"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17698606"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21540187"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"41100585"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7630397"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8684460"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8756328"}],"value":"Interacts with the CDK1 and CDK2 protein kinases to form serine/threonine kinase holoenzyme complexes (PubMed:1312467, PubMed:7630397, PubMed:8684460, PubMed:8756328, PubMed:41100585). Interacts with CDK1 (hyperphosphorylated form in G1 and underphosphorylated forms in S and G2) (PubMed:1312467). Interacts with CDK2; the interaction increases from G1 to G2 (PubMed:1312467). Interacts (associated with CDK2 but not with CDK1) with SCAPER; regulates the activity of CCNA2/CDK2 by transiently maintaining CCNA2 in the cytoplasm (PubMed:17698606). Forms a ternary complex with CDK2 and CDKN1B; CDKN1B inhibits the kinase activity of CDK2 through conformational rearrangements (PubMed:8684460). Interacts with INCA1 (PubMed:21540187)"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24101496"}],"value":"(Microbial infection) Interacts with human cytomegalovirus protein UL32"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P20248","intActId":"EBI-457097"},"interactantTwo":{"uniProtKBAccession":"P31749","geneName":"AKT1","intActId":"EBI-296087"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P20248","intActId":"EBI-457097"},"interactantTwo":{"uniProtKBAccession":"P24941","geneName":"CDK2","intActId":"EBI-375096"},"numberOfExperiments":34,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P20248","intActId":"EBI-457097"},"interactantTwo":{"uniProtKBAccession":"P38936","geneName":"CDKN1A","intActId":"EBI-375077"},"numberOfExperiments":8,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P20248","intActId":"EBI-457097"},"interactantTwo":{"uniProtKBAccession":"P46527","geneName":"CDKN1B","intActId":"EBI-519280"},"numberOfExperiments":21,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P20248","intActId":"EBI-457097"},"interactantTwo":{"uniProtKBAccession":"Q96PU4","geneName":"UHRF2","intActId":"EBI-625304"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P20248","intActId":"EBI-457097"},"interactantTwo":{"uniProtKBAccession":"P03129","geneName":"E7","intActId":"EBI-866453"},"numberOfExperiments":2,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"P20248","intActId":"EBI-457097"},"interactantTwo":{"uniProtKBAccession":"P03070","intActId":"EBI-617698"},"numberOfExperiments":2,"organismDiffer":true}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1312467"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17698606"}],"value":"Exclusively nuclear during interphase (PubMed:1312467). Detected in the nucleus and the cytoplasm at prophase (PubMed:1312467). Cytoplasmic when associated with SCAPER (PubMed:17698606)"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1312467"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17698606"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1312467"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17698606"}],"value":"Cytoplasm","id":"SL-0086"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1312467"}],"value":"Accumulates steadily during G2 and is abruptly destroyed at mitosis. Not detected during the G1 phase of the cell cycle. It accumulates during the DNA synthesis/S phase and disappears as cells progress into mitosis, between prophase and metaphase (at protein level)"}],"commentType":"DEVELOPMENTAL STAGE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21596315"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31413110"}],"value":"Polyubiquitinated via 'Lys-11'-linked ubiquitin by the anaphase-promoting complex (APC/C), leading to its degradation by the proteasome (PubMed:21596315). Deubiquitinated and stabilized by USP37 enables entry into S phase (PubMed:21596315). Ubiquitinated during the G1 phase by the SCF(FBXO31) complex, leading to its proteasomal degradation (PubMed:31413110)"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the cyclin family. Cyclin AB subfamily"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":432,"modifier":"EXACT"}},"description":"Cyclin-A2","featureId":"PRO_0000080338"},{"type":"Region","location":{"start":{"value":26,"modifier":"EXACT"},"end":{"value":45,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":55,"modifier":"EXACT"},"end":{"value":75,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"N-acetylmethionine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19369195"}]},{"type":"Modified residue","location":{"start":{"value":5,"modifier":"EXACT"},"end":{"value":5,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19369195"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":55,"modifier":"EXACT"},"end":{"value":55,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19369195"}]},{"type":"Natural variant","location":{"start":{"value":163,"modifier":"EXACT"},"end":{"value":163,"modifier":"EXACT"}},"description":"in dbSNP:rs769242","featureCrossReferences":[{"database":"dbSNP","id":"rs769242"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14702039"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15489334"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1967822"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8202514"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.3"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.4"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.7"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18691976"}],"featureId":"VAR_018819","alternativeSequence":{"originalSequence":"I","alternativeSequences":["V"]}},{"type":"Sequence conflict","location":{"start":{"value":156,"modifier":"EXACT"},"end":{"value":156,"modifier":"EXACT"}},"description":"in Ref. 3; CAG28620","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"H","alternativeSequences":["R"]}},{"type":"Turn","location":{"start":{"value":30,"modifier":"EXACT"},"end":{"value":32,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Q6G"}]},{"type":"Beta strand","location":{"start":{"value":54,"modifier":"EXACT"},"end":{"value":56,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Q6G"}]},{"type":"Helix","location":{"start":{"value":58,"modifier":"EXACT"},"end":{"value":61,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Q6G"}]},{"type":"Helix","location":{"start":{"value":172,"modifier":"EXACT"},"end":{"value":174,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4CFV"}]},{"type":"Turn","location":{"start":{"value":176,"modifier":"EXACT"},"end":{"value":178,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6ATH"}]},{"type":"Helix","location":{"start":{"value":179,"modifier":"EXACT"},"end":{"value":192,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4EOJ"}]},{"type":"Helix","location":{"start":{"value":194,"modifier":"EXACT"},"end":{"value":196,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4EOJ"}]},{"type":"Helix","location":{"start":{"value":199,"modifier":"EXACT"},"end":{"value":202,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4EOJ"}]},{"type":"Helix","location":{"start":{"value":208,"modifier":"EXACT"},"end":{"value":224,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4EOJ"}]},{"type":"Helix","location":{"start":{"value":229,"modifier":"EXACT"},"end":{"value":243,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4EOJ"}]},{"type":"Helix","location":{"start":{"value":250,"modifier":"EXACT"},"end":{"value":252,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4EOJ"}]},{"type":"Helix","location":{"start":{"value":253,"modifier":"EXACT"},"end":{"value":268,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4EOJ"}]},{"type":"Beta strand","location":{"start":{"value":269,"modifier":"EXACT"},"end":{"value":271,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2C5N"}]},{"type":"Helix","location":{"start":{"value":272,"modifier":"EXACT"},"end":{"value":274,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4EOJ"}]},{"type":"Helix","location":{"start":{"value":275,"modifier":"EXACT"},"end":{"value":281,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4EOJ"}]},{"type":"Turn","location":{"start":{"value":282,"modifier":"EXACT"},"end":{"value":284,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4EOJ"}]},{"type":"Helix","location":{"start":{"value":288,"modifier":"EXACT"},"end":{"value":301,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4EOJ"}]},{"type":"Turn","location":{"start":{"value":302,"modifier":"EXACT"},"end":{"value":304,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4EOJ"}]},{"type":"Helix","location":{"start":{"value":311,"modifier":"EXACT"},"end":{"value":319,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4EOJ"}]},{"type":"Beta strand","location":{"start":{"value":322,"modifier":"EXACT"},"end":{"value":324,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1H1P"}]},{"type":"Helix","location":{"start":{"value":327,"modifier":"EXACT"},"end":{"value":342,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4EOJ"}]},{"type":"Helix","location":{"start":{"value":344,"modifier":"EXACT"},"end":{"value":347,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4EOJ"}]},{"type":"Beta strand","location":{"start":{"value":348,"modifier":"EXACT"},"end":{"value":350,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8BYA"}]},{"type":"Helix","location":{"start":{"value":352,"modifier":"EXACT"},"end":{"value":368,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4EOJ"}]},{"type":"Helix","location":{"start":{"value":374,"modifier":"EXACT"},"end":{"value":380,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4EOJ"}]},{"type":"Helix","location":{"start":{"value":384,"modifier":"EXACT"},"end":{"value":400,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4EOJ"}]},{"type":"Helix","location":{"start":{"value":401,"modifier":"EXACT"},"end":{"value":403,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4EOJ"}]},{"type":"Beta strand","location":{"start":{"value":404,"modifier":"EXACT"},"end":{"value":406,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8BYA"}]},{"type":"Helix","location":{"start":{"value":408,"modifier":"EXACT"},"end":{"value":412,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4EOJ"}]},{"type":"Beta strand","location":{"start":{"value":413,"modifier":"EXACT"},"end":{"value":415,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1OL1"}]},{"type":"Helix","location":{"start":{"value":416,"modifier":"EXACT"},"end":{"value":418,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4EOJ"}]},{"type":"Helix","location":{"start":{"value":421,"modifier":"EXACT"},"end":{"value":423,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4EOJ"}]},{"type":"Helix","location":{"start":{"value":425,"modifier":"EXACT"},"end":{"value":427,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4EOJ"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0007","category":"PTM","name":"Acetylation"},{"id":"KW-0131","category":"Biological process","name":"Cell cycle"},{"id":"KW-0132","category":"Biological process","name":"Cell division"},{"id":"KW-0195","category":"Molecular function","name":"Cyclin"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0945","category":"Biological process","name":"Host-virus interaction"},{"id":"KW-0498","category":"Biological process","name":"Mitosis"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0832","category":"PTM","name":"Ubl conjugation"}],"references":[{"referenceNumber":1,"citation":{"id":"1967822","citationType":"journal article","authors":["Wang J.","Chenivesse X.","Henglein B.","Brechot C."],"citationCrossReferences":[{"database":"PubMed","id":"1967822"},{"database":"DOI","id":"10.1038/343555a0"}],"title":"Hepatitis B virus integration in a cyclin A gene in a hepatocellular carcinoma.","publicationDate":"1990","journal":"Nature","firstPage":"555","lastPage":"557","volume":"343"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]","VARIANT VAL-163"]},{"referenceNumber":2,"citation":{"id":"8202514","citationType":"journal article","authors":["Henglein B.","Chenivesse X.","Wang D.","Eick D.","Brechot C."],"citationCrossReferences":[{"database":"PubMed","id":"8202514"},{"database":"DOI","id":"10.1073/pnas.91.12.5490"}],"title":"Structure and cell cycle-regulated transcription of the human cyclin A gene.","publicationDate":"1994","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"5490","lastPage":"5494","volume":"91"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]","VARIANT VAL-163","DEVELOPMENTAL STAGE"]},{"referenceNumber":3,"citation":{"id":"CI-D49PLCHMKUIEL","citationType":"submission","authors":["Ebert L.","Schick M.","Neubert P.","Schatten R.","Henze S.","Korn B."],"title":"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201).","publicationDate":"MAY-2004","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]","VARIANT VAL-163"]},{"referenceNumber":4,"citation":{"id":"CI-6QAL9IGFBCC0B","citationType":"submission","authoringGroup":["NIEHS SNPs program"],"publicationDate":"JUN-2002","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]","VARIANT VAL-163"]},{"referenceNumber":5,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]","VARIANT VAL-163"]},{"referenceNumber":6,"citation":{"id":"15815621","citationType":"journal article","authors":["Hillier L.W.","Graves T.A.","Fulton R.S.","Fulton L.A.","Pepin K.H.","Minx P.","Wagner-McPherson C.","Layman D.","Wylie K.","Sekhon M.","Becker M.C.","Fewell G.A.","Delehaunty K.D.","Miner T.L.","Nash W.E.","Kremitzki C.","Oddy L.","Du H.","Sun H.","Bradshaw-Cordum H.","Ali J.","Carter J.","Cordes M.","Harris A.","Isak A.","van Brunt A.","Nguyen C.","Du F.","Courtney L.","Kalicki J.","Ozersky P.","Abbott S.","Armstrong J.","Belter E.A.","Caruso L.","Cedroni M.","Cotton M.","Davidson T.","Desai A.","Elliott G.","Erb T.","Fronick C.","Gaige T.","Haakenson W.","Haglund K.","Holmes A.","Harkins R.","Kim K.","Kruchowski S.S.","Strong C.M.","Grewal N.","Goyea E.","Hou S.","Levy A.","Martinka S.","Mead K.","McLellan M.D.","Meyer R.","Randall-Maher J.","Tomlinson C.","Dauphin-Kohlberg S.","Kozlowicz-Reilly A.","Shah N.","Swearengen-Shahid S.","Snider J.","Strong J.T.","Thompson J.","Yoakum M.","Leonard S.","Pearman C.","Trani L.","Radionenko M.","Waligorski J.E.","Wang C.","Rock S.M.","Tin-Wollam A.-M.","Maupin R.","Latreille P.","Wendl M.C.","Yang S.-P.","Pohl C.","Wallis J.W.","Spieth J.","Bieri T.A.","Berkowicz N.","Nelson J.O.","Osborne J.","Ding L.","Meyer R.","Sabo A.","Shotland Y.","Sinha P.","Wohldmann P.E.","Cook L.L.","Hickenbotham M.T.","Eldred J.","Williams D.","Jones T.A.","She X.","Ciccarelli F.D.","Izaurralde E.","Taylor J.","Schmutz J.","Myers R.M.","Cox D.R.","Huang X.","McPherson J.D.","Mardis E.R.","Clifton S.W.","Warren W.C.","Chinwalla A.T.","Eddy S.R.","Marra M.A.","Ovcharenko I.","Furey T.S.","Miller W.","Eichler E.E.","Bork P.","Suyama M.","Torrents D.","Waterston R.H.","Wilson R.K."],"citationCrossReferences":[{"database":"PubMed","id":"15815621"},{"database":"DOI","id":"10.1038/nature03466"}],"title":"Generation and annotation of the DNA sequences of human chromosomes 2 and 4.","publicationDate":"2005","journal":"Nature","firstPage":"724","lastPage":"731","volume":"434"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":7,"citation":{"id":"CI-5GBD0VIIJ7C63","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"SEP-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]","VARIANT VAL-163"]},{"referenceNumber":8,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]","VARIANT VAL-163"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":9,"citation":{"id":"1312467","citationType":"journal article","authors":["Pagano M.","Pepperkok R.","Verde F.","Ansorge W.","Draetta G."],"citationCrossReferences":[{"database":"PubMed","id":"1312467"},{"database":"DOI","id":"10.1002/j.1460-2075.1992.tb05135.x"}],"title":"Cyclin A is required at two points in the human cell cycle.","publicationDate":"1992","journal":"EMBO J.","firstPage":"961","lastPage":"971","volume":"11"},"referencePositions":["FUNCTION","INTERACTION WITH CDK1 AND CDK2","SUBCELLULAR LOCATION","DEVELOPMENTAL STAGE"]},{"referenceNumber":10,"citation":{"id":"17698606","citationType":"journal article","authors":["Tsang W.Y.","Wang L.","Chen Z.","Sanchez I.","Dynlacht B.D."],"citationCrossReferences":[{"database":"PubMed","id":"17698606"},{"database":"DOI","id":"10.1083/jcb.200701166"}],"title":"SCAPER, a novel cyclin A-interacting protein that regulates cell cycle progression.","publicationDate":"2007","journal":"J. Cell Biol.","firstPage":"621","lastPage":"633","volume":"178"},"referencePositions":["INTERACTION WITH SCAPER","SUBCELLULAR LOCATION"]},{"referenceNumber":11,"citation":{"id":"19369195","citationType":"journal article","authors":["Oppermann F.S.","Gnad F.","Olsen J.V.","Hornberger R.","Greff Z.","Keri G.","Mann M.","Daub H."],"citationCrossReferences":[{"database":"PubMed","id":"19369195"},{"database":"DOI","id":"10.1074/mcp.m800588-mcp200"}],"title":"Large-scale proteomics analysis of the human kinome.","publicationDate":"2009","journal":"Mol. Cell. Proteomics","firstPage":"1751","lastPage":"1764","volume":"8"},"referencePositions":["ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1","PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-5 AND SER-55","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":12,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Buerckstuemmer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":13,"citation":{"id":"21540187","citationType":"journal article","authors":["Baeumer N.","Tickenbrock L.","Tschanter P.","Lohmeyer L.","Diederichs S.","Baeumer S.","Skryabin B.V.","Zhang F.","Agrawal-Singh S.","Koehler G.","Berdel W.E.","Serve H.","Koschmieder S.","Mueller-Tidow C."],"citationCrossReferences":[{"database":"PubMed","id":"21540187"},{"database":"DOI","id":"10.1074/jbc.m110.203471"}],"title":"Inhibitor of cyclin-dependent kinase (CDK) interacting with cyclin A1 (INCA1) regulates proliferation and is repressed by oncogenic signaling.","publicationDate":"2011","journal":"J. Biol. Chem.","firstPage":"28210","lastPage":"28222","volume":"286"},"referencePositions":["INTERACTION WITH INCA1"]},{"referenceNumber":14,"citation":{"id":"21596315","citationType":"journal article","authors":["Huang X.","Summers M.K.","Pham V.","Lill J.R.","Liu J.","Lee G.","Kirkpatrick D.S.","Jackson P.K.","Fang G.","Dixit V.M."],"citationCrossReferences":[{"database":"PubMed","id":"21596315"},{"database":"DOI","id":"10.1016/j.molcel.2011.03.027"}],"title":"Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entry.","publicationDate":"2011","journal":"Mol. Cell","firstPage":"511","lastPage":"523","volume":"42"},"referencePositions":["UBIQUITINATION","DEUBIQUITINATION BY USP37"]},{"referenceNumber":15,"citation":{"id":"22814378","citationType":"journal article","authors":["Van Damme P.","Lasa M.","Polevoda B.","Gazquez C.","Elosegui-Artola A.","Kim D.S.","De Juan-Pardo E.","Demeyer K.","Hole K.","Larrea E.","Timmerman E.","Prieto J.","Arnesen T.","Sherman F.","Gevaert K.","Aldabe R."],"citationCrossReferences":[{"database":"PubMed","id":"22814378"},{"database":"DOI","id":"10.1073/pnas.1210303109"}],"title":"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.","publicationDate":"2012","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"12449","lastPage":"12454","volume":"109"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":16,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"},{"database":"DOI","id":"10.1021/pr300630k"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-5","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Erythroleukemia","type":"TISSUE"}]},{"referenceNumber":17,"citation":{"id":"24101496","citationType":"journal article","authors":["Bogdanow B.","Weisbach H.","von Einem J.","Straschewski S.","Voigt S.","Winkler M.","Hagemeier C.","Wiebusch L."],"citationCrossReferences":[{"database":"PubMed","id":"24101496"},{"database":"DOI","id":"10.1073/pnas.1312235110"}],"title":"Human cytomegalovirus tegument protein pp150 acts as a cyclin A2-CDK-dependent sensor of the host cell cycle and differentiation state.","publicationDate":"2013","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"17510","lastPage":"17515","volume":"110"},"referencePositions":["INTERACTION WITH HUMAN CYTOMEGALOVIRUS UL32 (MICROBIAL INFECTION)"]},{"referenceNumber":18,"citation":{"id":"31413110","citationType":"journal article","authors":["Dutta P.","Islam S.","Choppara S.","Sengupta P.","Kumar A.","Kumar A.","Wani M.R.","Chatterjee S.","Santra M.K."],"citationCrossReferences":[{"database":"PubMed","id":"31413110"},{"database":"DOI","id":"10.1074/jbc.ra118.007055"}],"title":"The tumor suppressor FBXO31 preserves genomic integrity by regulating DNA replication and segregation through precise control of cyclin A levels.","publicationDate":"2019","journal":"J. Biol. Chem.","firstPage":"14879","lastPage":"14895","volume":"294"},"referencePositions":["UBIQUITINATION"]},{"referenceNumber":19,"citation":{"id":"7630397","citationType":"journal article","authors":["Jeffrey P.D.","Russo A.A.","Polyak K.","Gibbs E.","Hurwitz J.","Massague J.","Pavletich N.P."],"citationCrossReferences":[{"database":"PubMed","id":"7630397"},{"database":"DOI","id":"10.1038/376313a0"}],"title":"Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex.","publicationDate":"1995","journal":"Nature","firstPage":"313","lastPage":"320","volume":"376"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 173-432 IN COMPLEX WITH CDK2"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"1FIN"}]},{"referenceNumber":20,"citation":{"id":"8684460","citationType":"journal article","authors":["Russo A.A.","Jeffrey P.D.","Patten A.K.","Massague J.","Pavletich N.P."],"citationCrossReferences":[{"database":"PubMed","id":"8684460"},{"database":"DOI","id":"10.1038/382325a0"}],"title":"Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex.","publicationDate":"1996","journal":"Nature","firstPage":"325","lastPage":"331","volume":"382"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 173-432 IN COMPLEX WITH CDK2 AND CDKN1B"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"1JSU"}]},{"referenceNumber":21,"citation":{"id":"8756328","citationType":"journal article","authors":["Russo A.A.","Jeffrey P.D.","Pavletich N.P."],"citationCrossReferences":[{"database":"PubMed","id":"8756328"},{"database":"DOI","id":"10.1038/nsb0896-696"}],"title":"Structural basis of cyclin-dependent kinase activation by phosphorylation.","publicationDate":"1996","journal":"Nat. Struct. Biol.","firstPage":"696","lastPage":"700","volume":"3"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 173-432 IN COMPLEX WITH CDK2"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"1JST"}]},{"referenceNumber":22,"citation":{"id":"41100585","citationType":"journal article","authors":["Cushing V.I.","McGeoch A.J.S.","Williams S.L.","Roumeliotis T.I.","Feng J.","Dan L.M.","Choudhary J.S.","Davey N.E.","Greber B.J."],"citationCrossReferences":[{"database":"PubMed","id":"41100585"},{"database":"DOI","id":"10.1126/science.adw0053"}],"title":"Structural basis of T-loop-independent recognition and activation of CDKs by the CDK-activating kinase.","publicationDate":"2025","journal":"Science","firstPage":"911","lastPage":"917","volume":"390"},"referencePositions":["STRUCTURE BY ELECTRON MICROSCOPY (2.50 ANGSTROMS)","FUNCTION","SUBUNIT"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"9QCV"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"9QCX"}]},{"referenceNumber":23,"citation":{"id":"18691976","citationType":"journal article","authors":["Daub H.","Olsen J.V.","Bairlein M.","Gnad F.","Oppermann F.S.","Korner R.","Greff Z.","Keri G.","Stemmann O.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"18691976"},{"database":"DOI","id":"10.1016/j.molcel.2008.07.007"}],"title":"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.","publicationDate":"2008","journal":"Mol. Cell","firstPage":"438","lastPage":"448","volume":"31"},"referencePositions":["VARIANT [LARGE SCALE ANALYSIS] VAL-163","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"X51688","properties":[{"key":"ProteinId","value":"CAA35986.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"X68303","properties":[{"key":"ProteinId","value":"CAA48375.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CR407692","properties":[{"key":"ProteinId","value":"CAG28620.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF518006","properties":[{"key":"ProteinId","value":"AAM54042.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AK291931","properties":[{"key":"ProteinId","value":"BAF84620.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AC079341","properties":[{"key":"ProteinId","value":"AAY40969.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471056","properties":[{"key":"ProteinId","value":"EAX05246.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC104783","properties":[{"key":"ProteinId","value":"AAI04784.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC104787","properties":[{"key":"ProteinId","value":"AAI04788.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS3723.1","properties":[{"key":"Description","value":"-"}]},{"database":"PIR","id":"S08277","properties":[{"key":"EntryName","value":"S08277"}]},{"database":"RefSeq","id":"NP_001228.2","properties":[{"key":"NucleotideSequenceId","value":"NM_001237.5"}]},{"database":"PDB","id":"1E9H","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"B/D=175-432"}]},{"database":"PDB","id":"1FIN","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"B/D=173-432"}]},{"database":"PDB","id":"1FVV","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.80 A"},{"key":"Chains","value":"B/D=173-432"}]},{"database":"PDB","id":"1GY3","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.70 A"},{"key":"Chains","value":"B/D=175-432"}]},{"database":"PDB","id":"1H1P","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.10 A"},{"key":"Chains","value":"B/D=175-432"}]},{"database":"PDB","id":"1H1Q","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"B/D=175-432"}]},{"database":"PDB","id":"1H1R","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"B/D=175-432"}]},{"database":"PDB","id":"1H1S","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"B/D=175-432"}]},{"database":"PDB","id":"1H24","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"B/D=174-432"}]},{"database":"PDB","id":"1H25","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"B/D=174-432"}]},{"database":"PDB","id":"1H26","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.24 A"},{"key":"Chains","value":"B/D=174-432"}]},{"database":"PDB","id":"1H27","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.20 A"},{"key":"Chains","value":"B/D=174-432"}]},{"database":"PDB","id":"1H28","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.80 A"},{"key":"Chains","value":"B/D=174-432"}]},{"database":"PDB","id":"1JST","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.60 A"},{"key":"Chains","value":"B/D=175-432"}]},{"database":"PDB","id":"1JSU","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"B=173-432"}]},{"database":"PDB","id":"1OGU","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.60 A"},{"key":"Chains","value":"B/D=174-432"}]},{"database":"PDB","id":"1OI9","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.10 A"},{"key":"Chains","value":"B/D=174-432"}]},{"database":"PDB","id":"1OIU","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"B/D=174-432"}]},{"database":"PDB","id":"1OIY","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.40 A"},{"key":"Chains","value":"B/D=174-432"}]},{"database":"PDB","id":"1OKV","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.40 A"},{"key":"Chains","value":"B/D=173-432"}]},{"database":"PDB","id":"1OKW","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"B/D=173-432"}]},{"database":"PDB","id":"1OL1","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.90 A"},{"key":"Chains","value":"B/D=173-432"}]},{"database":"PDB","id":"1OL2","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.60 A"},{"key":"Chains","value":"B/D=173-432"}]},{"database":"PDB","id":"1P5E","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.22 A"},{"key":"Chains","value":"B/D=175-432"}]},{"database":"PDB","id":"1PKD","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"B/D=175-432"}]},{"database":"PDB","id":"1QMZ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.20 A"},{"key":"Chains","value":"B/D=174-432"}]},{"database":"PDB","id":"1URC","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.60 A"},{"key":"Chains","value":"B/D=173-432"}]},{"database":"PDB","id":"1VYW","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"B/D=169-432"}]},{"database":"PDB","id":"2BKZ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.60 A"},{"key":"Chains","value":"B/D=169-432"}]},{"database":"PDB","id":"2BPM","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.40 A"},{"key":"Chains","value":"B/D=169-432"}]},{"database":"PDB","id":"2C4G","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.70 A"},{"key":"Chains","value":"B/D=169-432"}]},{"database":"PDB","id":"2C5N","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.10 A"},{"key":"Chains","value":"B/D=174-432"}]},{"database":"PDB","id":"2C5O","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.10 A"},{"key":"Chains","value":"B/D=173-432"}]},{"database":"PDB","id":"2C5V","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.90 A"},{"key":"Chains","value":"B/D=174-432"}]},{"database":"PDB","id":"2C5X","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.90 A"},{"key":"Chains","value":"B/D=174-432"}]},{"database":"PDB","id":"2C6T","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.61 A"},{"key":"Chains","value":"B/D=175-432"}]},{"database":"PDB","id":"2CCH","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.70 A"},{"key":"Chains","value":"B/D=173-432"}]},{"database":"PDB","id":"2CCI","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.70 A"},{"key":"Chains","value":"B/D=175-432"}]},{"database":"PDB","id":"2CJM","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"B/D=175-432"}]},{"database":"PDB","id":"2I40","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.80 A"},{"key":"Chains","value":"B/D=173-432"}]},{"database":"PDB","id":"2IW6","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"B/D=174-432"}]},{"database":"PDB","id":"2IW8","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"B/D=174-432"}]},{"database":"PDB","id":"2IW9","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"B/D=174-432"}]},{"database":"PDB","id":"2UUE","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.06 A"},{"key":"Chains","value":"B/D=174-432"}]},{"database":"PDB","id":"2UZB","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.70 A"},{"key":"Chains","value":"B/D=175-432"}]},{"database":"PDB","id":"2UZD","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.72 A"},{"key":"Chains","value":"B/D=175-432"}]},{"database":"PDB","id":"2UZE","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.40 A"},{"key":"Chains","value":"B/D=175-432"}]},{"database":"PDB","id":"2UZL","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.40 A"},{"key":"Chains","value":"B/D=175-432"}]},{"database":"PDB","id":"2V22","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.60 A"},{"key":"Chains","value":"B/D=174-432"}]},{"database":"PDB","id":"2WEV","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"B/D=173-432"}]},{"database":"PDB","id":"2WFY","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.53 A"},{"key":"Chains","value":"B/D=173-432"}]},{"database":"PDB","id":"2WHB","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.90 A"},{"key":"Chains","value":"B/D=173-432"}]},{"database":"PDB","id":"2WIH","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"B/D=173-432"}]},{"database":"PDB","id":"2WIP","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.80 A"},{"key":"Chains","value":"B/D=169-432"}]},{"database":"PDB","id":"2WMA","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.80 A"},{"key":"Chains","value":"B/D=174-432"}]},{"database":"PDB","id":"2WMB","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.60 A"},{"key":"Chains","value":"B/D=174-432"}]},{"database":"PDB","id":"2WPA","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.51 A"},{"key":"Chains","value":"B/D=169-432"}]},{"database":"PDB","id":"2WXV","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.60 A"},{"key":"Chains","value":"B/D=169-432"}]},{"database":"PDB","id":"2X1N","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.75 A"},{"key":"Chains","value":"B/D=172-432"}]},{"database":"PDB","id":"3EID","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.15 A"},{"key":"Chains","value":"B/D=173-432"}]},{"database":"PDB","id":"3EJ1","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.22 A"},{"key":"Chains","value":"B/D=173-432"}]},{"database":"PDB","id":"3EOC","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.20 A"},{"key":"Chains","value":"B/D=173-432"}]},{"database":"PDB","id":"3F5X","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.40 A"},{"key":"Chains","value":"B/D=177-432"}]},{"database":"PDB","id":"4BCK","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.05 A"},{"key":"Chains","value":"B/D=171-432"}]},{"database":"PDB","id":"4BCM","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.45 A"},{"key":"Chains","value":"B/D=171-432"}]},{"database":"PDB","id":"4BCN","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.10 A"},{"key":"Chains","value":"B=171-432"}]},{"database":"PDB","id":"4BCP","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.26 A"},{"key":"Chains","value":"B/D=171-432"}]},{"database":"PDB","id":"4CFM","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.85 A"},{"key":"Chains","value":"B/D=175-432"}]},{"database":"PDB","id":"4CFN","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.20 A"},{"key":"Chains","value":"B/D=175-432"}]},{"database":"PDB","id":"4CFU","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.20 A"},{"key":"Chains","value":"B=172-432, D=173-432"}]},{"database":"PDB","id":"4CFV","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"B/D=172-432"}]},{"database":"PDB","id":"4CFW","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.45 A"},{"key":"Chains","value":"B/D=175-432"}]},{"database":"PDB","id":"4CFX","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.50 A"},{"key":"Chains","value":"B/D=173-432"}]},{"database":"PDB","id":"4EOI","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"B/D=175-432"}]},{"database":"PDB","id":"4EOJ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.65 A"},{"key":"Chains","value":"B/D=175-432"}]},{"database":"PDB","id":"4EOK","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.57 A"},{"key":"Chains","value":"B/D=175-432"}]},{"database":"PDB","id":"4EOL","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.40 A"},{"key":"Chains","value":"B/D=175-432"}]},{"database":"PDB","id":"4EOM","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.10 A"},{"key":"Chains","value":"B/D=175-432"}]},{"database":"PDB","id":"4EON","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.40 A"},{"key":"Chains","value":"B/D=175-432"}]},{"database":"PDB","id":"4EOO","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.10 A"},{"key":"Chains","value":"B/D=175-432"}]},{"database":"PDB","id":"4EOP","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.99 A"},{"key":"Chains","value":"B/D=175-432"}]},{"database":"PDB","id":"4EOQ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.15 A"},{"key":"Chains","value":"B/D=175-432"}]},{"database":"PDB","id":"4EOR","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.20 A"},{"key":"Chains","value":"B/D=175-432"}]},{"database":"PDB","id":"4EOS","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.57 A"},{"key":"Chains","value":"B/D=175-432"}]},{"database":"PDB","id":"4FX3","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.75 A"},{"key":"Chains","value":"B/D=175-432"}]},{"database":"PDB","id":"5CYI","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"B/D=174-432"}]},{"database":"PDB","id":"5IF1","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.61 A"},{"key":"Chains","value":"B/D=174-432"}]},{"database":"PDB","id":"5LMK","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.40 A"},{"key":"Chains","value":"B/D=175-432"}]},{"database":"PDB","id":"5NEV","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.97 A"},{"key":"Chains","value":"B/D=174-432"}]},{"database":"PDB","id":"6ATH","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.82 A"},{"key":"Chains","value":"B=173-432"}]},{"database":"PDB","id":"6GVA","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.15 A"},{"key":"Chains","value":"B=175-432"}]},{"database":"PDB","id":"6P3W","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.54 A"},{"key":"Chains","value":"B/D=176-432"}]},{"database":"PDB","id":"6Q6G","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.20 A"},{"key":"Chains","value":"S=1-432"}]},{"database":"PDB","id":"6Q6H","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.20 A"},{"key":"Chains","value":"S=1-432"}]},{"database":"PDB","id":"6RIJ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.20 A"},{"key":"Chains","value":"B/D=175-432"}]},{"database":"PDB","id":"6SG4","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.43 A"},{"key":"Chains","value":"B/D=174-432"}]},{"database":"PDB","id":"7ACK","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"B/D=175-432"}]},{"database":"PDB","id":"7B5L","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.80 A"},{"key":"Chains","value":"Y=1-432"}]},{"database":"PDB","id":"7B5R","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.80 A"},{"key":"Chains","value":"Y=1-432"}]},{"database":"PDB","id":"7B7S","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.54 A"},{"key":"Chains","value":"B/D=175-432"}]},{"database":"PDB","id":"7LUO","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.17 A"},{"key":"Chains","value":"A/C=174-432"}]},{"database":"PDB","id":"7MKX","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.08 A"},{"key":"Chains","value":"B/D=171-432"}]},{"database":"PDB","id":"7QHL","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.70 A"},{"key":"Chains","value":"B/D=175-432"}]},{"database":"PDB","id":"8B54","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.60 A"},{"key":"Chains","value":"B/D=175-432"}]},{"database":"PDB","id":"8BYA","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.38 A"},{"key":"Chains","value":"B=1-432"}]},{"database":"PDB","id":"8BZO","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.50 A"},{"key":"Chains","value":"B=1-432"}]},{"database":"PDB","id":"9D97","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.60 A"},{"key":"Chains","value":"C=178-186"}]},{"database":"PDB","id":"9GLA","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.18 A"},{"key":"Chains","value":"B=175-432"}]},{"database":"PDB","id":"9HIU","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.20 A"},{"key":"Chains","value":"A=1-432"}]},{"database":"PDB","id":"9HIW","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.10 A"},{"key":"Chains","value":"A=1-432"}]},{"database":"PDB","id":"9HJ1","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.90 A"},{"key":"Chains","value":"A=1-432"}]},{"database":"PDB","id":"9QCV","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"L=1-432"}]},{"database":"PDB","id":"9QCX","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.60 A"},{"key":"Chains","value":"L=1-432"}]},{"database":"PDB","id":"9QJJ","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"A=1-432"}]},{"database":"PDBsum","id":"1E9H","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1FIN","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1FVV","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1GY3","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1H1P","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1H1Q","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1H1R","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1H1S","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1H24","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1H25","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1H26","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1H27","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1H28","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1JST","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1JSU","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1OGU","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1OI9","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1OIU","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1OIY","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1OKV","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1OKW","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1OL1","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1OL2","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1P5E","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1PKD","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1QMZ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1URC","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1VYW","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2BKZ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2BPM","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2C4G","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2C5N","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2C5O","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2C5V","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2C5X","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2C6T","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2CCH","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2CCI","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2CJM","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2I40","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2IW6","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2IW8","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2IW9","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2UUE","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2UZB","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2UZD","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2UZE","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2UZL","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2V22","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2WEV","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2WFY","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2WHB","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2WIH","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2WIP","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2WMA","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2WMB","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2WPA","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2WXV","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2X1N","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3EID","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3EJ1","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3EOC","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3F5X","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4BCK","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4BCM","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4BCN","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4BCP","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4CFM","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4CFN","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4CFU","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4CFV","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4CFW","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4CFX","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4EOI","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4EOJ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4EOK","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4EOL","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4EOM","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4EON","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4EOO","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4EOP","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4EOQ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4EOR","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4EOS","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4FX3","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5CYI","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5IF1","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5LMK","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5NEV","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6ATH","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6GVA","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6P3W","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6Q6G","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6Q6H","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6RIJ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6SG4","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7ACK","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7B5L","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7B5R","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7B7S","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7LUO","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7MKX","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7QHL","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8B54","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8BYA","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8BZO","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9D97","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9GLA","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9HIU","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9HIW","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9HJ1","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9QCV","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9QCX","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9QJJ","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"P20248","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-12037","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-12048","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-16325","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-16344","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-4465","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-4466","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-4467","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-52201","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-52204","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-52208","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-52759","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-53027","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-53028","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-53204","properties":[{"key":"Description","value":"-"}]},{"database":"MDposit","id":"P20248","properties":[{"key":"Description","value":"-"}]},{"database":"MDRepo","id":"P20248","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P20248","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"107331","properties":[{"key":"Interactions","value":"186"}]},{"database":"ComplexPortal","id":"CPX-2004","properties":[{"key":"EntryName","value":"Cyclin A2-CDK1 complex"}]},{"database":"ComplexPortal","id":"CPX-2006","properties":[{"key":"EntryName","value":"Cyclin A2-CDK2 complex"}]},{"database":"CORUM","id":"P20248","properties":[{"key":"Description","value":"-"}]},{"database":"DIP","id":"DIP-638N","properties":[{"key":"Description","value":"-"}]},{"database":"ELM","id":"P20248","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P20248","properties":[{"key":"Number of interactors","value":"2344"}]},{"database":"IntAct","id":"P20248","properties":[{"key":"Interactions","value":"104"}]},{"database":"MINT","id":"P20248","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-CCNA2","properties":[{"key":"Evidences","value":"18 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000481380","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"P20248","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL2582","properties":[{"key":"Description","value":"-"}]},{"database":"DrugBank","id":"DB08463","properties":[{"key":"GenericName","value":"(2R)-2-({9-(1-methylethyl)-6-[(4-pyridin-2-ylbenzyl)amino]-9H-purin-2-yl}amino)butan-1-ol"}]},{"database":"DrugBank","id":"DB08285","properties":[{"key":"GenericName","value":"(2R)-2-{[4-(benzylamino)-8-(1-methylethyl)pyrazolo[1,5-a][1,3,5]triazin-2-yl]amino}butan-1-ol"}]},{"database":"DrugBank","id":"DB07137","properties":[{"key":"GenericName","value":"(2S)-N-[(3E)-5-Cyclopropyl-3H-pyrazol-3-ylidene]-2-[4-(2-oxo-1-imidazolidinyl)phenyl]propanamide"}]},{"database":"DrugBank","id":"DB07852","properties":[{"key":"GenericName","value":"1-(3,5-DICHLOROPHENYL)-5-METHYL-1H-1,2,4-TRIAZOLE-3-CARBOXYLIC ACID"}]},{"database":"DrugBank","id":"DB08527","properties":[{"key":"GenericName","value":"1-[4-(AMINOSULFONYL)PHENYL]-1,6-DIHYDROPYRAZOLO[3,4-E]INDAZOLE-3-CARBOXAMIDE"}]},{"database":"DrugBank","id":"DB08355","properties":[{"key":"GenericName","value":"1-methyl-8-(phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylic acid"}]},{"database":"DrugBank","id":"DB06948","properties":[{"key":"GenericName","value":"2-ANILINO-6-CYCLOHEXYLMETHOXYPURINE"}]},{"database":"DrugBank","id":"DB08248","properties":[{"key":"GenericName","value":"3-(6-CYCLOHEXYLMETHOXY-9H-PURIN-2-YLAMINO)-BENZENESULFONAMIDE"}]},{"database":"DrugBank","id":"DB08309","properties":[{"key":"GenericName","value":"3-({2-[(4-{[6-(CYCLOHEXYLMETHOXY)-9H-PURIN-2-YL]AMINO}PHENYL)SULFONYL]ETHYL}AMINO)PROPAN-1-OL"}]},{"database":"DrugBank","id":"DB02915","properties":[{"key":"GenericName","value":"4-(2,4-Dimethyl-1,3-thiazol-5-yl)-N-[4-(trifluoromethyl)phenyl]-2-pyrimidinamine"}]},{"database":"DrugBank","id":"DB02091","properties":[{"key":"GenericName","value":"4-(2,4-Dimethyl-Thiazol-5-Yl)-Pyrimidin-2-Ylamine"}]},{"database":"DrugBank","id":"DB08178","properties":[{"key":"GenericName","value":"4-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amine"}]},{"database":"DrugBank","id":"DB08182","properties":[{"key":"GenericName","value":"4-(4-propoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amine"}]},{"database":"DrugBank","id":"DB08241","properties":[{"key":"GenericName","value":"4-(6-CYCLOHEXYLMETHOXY-9H-PURIN-2-YLAMINO)--BENZAMIDE"}]},{"database":"DrugBank","id":"DB06844","properties":[{"key":"GenericName","value":"4-[(7-OXO-7H-THIAZOLO[5,4-E]INDOL-8-YLMETHYL)-AMINO]-N-PYRIDIN-2-YL-BENZENESULFONAMIDE"}]},{"database":"DrugBank","id":"DB08219","properties":[{"key":"GenericName","value":"4-Methyl-5-[(2Z)-2-{[4-(4-morpholinyl)phenyl]imino}-2,5-dihydro-4-pyrimidinyl]-1,3-thiazol-2-amine"}]},{"database":"DrugBank","id":"DB07533","properties":[{"key":"GenericName","value":"4-{5-[(Z)-(2-Imino-4-Oxo-1,3-Thiazolidin-5-Ylidene)methyl]-2-Furyl}-N-Methylbenzenesulfonamide"}]},{"database":"DrugBank","id":"DB07538","properties":[{"key":"GenericName","value":"4-{5-[(Z)-(2-IMINO-4-OXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]FURAN-2-YL}-2-(TRIFLUOROMETHYL)BENZENESULFONAMIDE"}]},{"database":"DrugBank","id":"DB07534","properties":[{"key":"GenericName","value":"4-{5-[(Z)-(2-Imino-4-Oxo-1,3-Thiazolidin-5-Ylidene)methyl]furan-2-Yl}benzenesulfonamide"}]},{"database":"DrugBank","id":"DB07539","properties":[{"key":"GenericName","value":"4-{5-[(Z)-(2-IMINO-4-OXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]FURAN-2-YL}BENZOIC ACID"}]},{"database":"DrugBank","id":"DB08572","properties":[{"key":"GenericName","value":"4-{[4-AMINO-6-(CYCLOHEXYLMETHOXY)-5-NITROSOPYRIMIDIN-2-YL]AMINO}BENZAMIDE"}]},{"database":"DrugBank","id":"DB07688","properties":[{"key":"GenericName","value":"4-{[5-(CYCLOHEXYLOXY)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL]AMINO}BENZENESULFONAMIDE"}]},{"database":"DrugBank","id":"DB07471","properties":[{"key":"GenericName","value":"5-[5,6-BIS(METHYLOXY)-1H-BENZIMIDAZOL-1-YL]-3-{[1-(2-CHLOROPHENYL)ETHYL]OXY}-2-THIOPHENECARBOXAMIDE"}]},{"database":"DrugBank","id":"DB07203","properties":[{"key":"GenericName","value":"6-CYCLOHEXYLMETHOXY-2-(3'-CHLOROANILINO) PURINE"}]},{"database":"DrugBank","id":"DB08233","properties":[{"key":"GenericName","value":"6-CYCLOHEXYLMETHYLOXY-2-(4'-HYDROXYANILINO)PURINE"}]},{"database":"DrugBank","id":"DB02407","properties":[{"key":"GenericName","value":"6-O-Cyclohexylmethyl Guanine"}]},{"database":"DrugBank","id":"DB02833","properties":[{"key":"GenericName","value":"[4-(2-Amino-4-Methyl-Thiazol-5-Yl)-Pyrimidin-2-Yl]-(3-Nitro-Phenyl)-Amine"}]},{"database":"DrugBank","id":"DB08218","properties":[{"key":"GenericName","value":"HYDROXY(OXO)(3-{[(2Z)-4-[3-(1H-1,2,4-TRIAZOL-1-YLMETHYL)PHENYL]PYRIMIDIN-2(5H)-YLIDENE]AMINO}PHENYL)AMMONIUM"}]},{"database":"DrugBank","id":"DB06944","properties":[{"key":"GenericName","value":"N-(3-cyclopropyl-1H-pyrazol-5-yl)-2-(2-naphthyl)acetamide"}]},{"database":"DrugBank","id":"DB07562","properties":[{"key":"GenericName","value":"N-[4-(2,4-DIMETHYL-THIAZOL-5-YL)-PYRIMIDIN-2-YL]-N',N'-DIMETHYL-BENZENE-1,4-DIAMINE"}]},{"database":"DrugBank","id":"DB07164","properties":[{"key":"GenericName","value":"N-cyclopropyl-4-pyrazolo[1,5-b]pyridazin-3-ylpyrimidin-2-amine"}]},{"database":"DrugBank","id":"DB07126","properties":[{"key":"GenericName","value":"O6-CYCLOHEXYLMETHOXY-2-(4'-SULPHAMOYLANILINO) PURINE"}]},{"database":"DrugBank","id":"DB08694","properties":[{"key":"GenericName","value":"Variolin B"}]},{"database":"DrugCentral","id":"P20248","properties":[{"key":"Description","value":"-"}]},{"database":"iPTMnet","id":"P20248","properties":[{"key":"Description","value":"-"}]},{"database":"MetOSite","id":"P20248","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"P20248","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"CCNA2","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"311033358","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"P20248","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"P20248","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000481380","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P20248","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"53735","properties":[{"key":"Description","value":"-"}]},{"database":"Pumba","id":"P20248","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"3665","properties":[{"key":"antibodies","value":"839 antibodies from 46 providers"}]},{"database":"DNASU","id":"890","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000274026.10","properties":[{"key":"ProteinId","value":"ENSP00000274026.5"},{"key":"GeneId","value":"ENSG00000145386.12"}]},{"database":"GeneID","id":"890","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:890","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000274026.10","properties":[{"key":"ProteinId","value":"ENSP00000274026.5"},{"key":"RefSeqNucleotideId","value":"NM_001237.5"},{"key":"RefSeqProteinId","value":"NP_001228.2"}]},{"database":"UCSC","id":"uc003iec.5","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:1578","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA94","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"890","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"890","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"CCNA2","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:1578","properties":[{"key":"GeneName","value":"CCNA2"}]},{"database":"HPA","id":"ENSG00000145386","properties":[{"key":"ExpressionPatterns","value":"Tissue enhanced (bone marrow, lymphoid tissue, retina)"}]},{"database":"MalaCards","id":"CCNA2","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"123835","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000145386","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000145386","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG0654","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000155372","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_020695_3_2_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P20248","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"YCRAAQH","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"5590282at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"P20248","properties":[{"key":"Number of GO annotations","value":"6 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"P20248","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"P20248","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-1362300","properties":[{"key":"PathwayName","value":"Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1"}]},{"database":"Reactome","id":"R-HSA-1538133","properties":[{"key":"PathwayName","value":"G0 and Early G1"}]},{"database":"Reactome","id":"R-HSA-171319","properties":[{"key":"PathwayName","value":"Telomere Extension By Telomerase"}]},{"database":"Reactome","id":"R-HSA-174184","properties":[{"key":"PathwayName","value":"Cdc20:Phospho-APC/C mediated degradation of Cyclin A"}]},{"database":"Reactome","id":"R-HSA-176408","properties":[{"key":"PathwayName","value":"Regulation of APC/C activators between G1/S and early anaphase"}]},{"database":"Reactome","id":"R-HSA-187577","properties":[{"key":"PathwayName","value":"SCF(Skp2)-mediated degradation of p27/p21"}]},{"database":"Reactome","id":"R-HSA-2559582","properties":[{"key":"PathwayName","value":"Senescence-Associated Secretory Phenotype (SASP)"}]},{"database":"Reactome","id":"R-HSA-2559586","properties":[{"key":"PathwayName","value":"DNA Damage/Telomere Stress Induced Senescence"}]},{"database":"Reactome","id":"R-HSA-5689880","properties":[{"key":"PathwayName","value":"Ub-specific processing proteases"}]},{"database":"Reactome","id":"R-HSA-5693607","properties":[{"key":"PathwayName","value":"Processing of DNA double-strand break ends"}]},{"database":"Reactome","id":"R-HSA-6804116","properties":[{"key":"PathwayName","value":"TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest"}]},{"database":"Reactome","id":"R-HSA-6804756","properties":[{"key":"PathwayName","value":"Regulation of TP53 Activity through Phosphorylation"}]},{"database":"Reactome","id":"R-HSA-6804757","properties":[{"key":"PathwayName","value":"Regulation of TP53 Degradation"}]},{"database":"Reactome","id":"R-HSA-68911","properties":[{"key":"PathwayName","value":"G2 Phase"}]},{"database":"Reactome","id":"R-HSA-68949","properties":[{"key":"PathwayName","value":"Orc1 removal from chromatin"}]},{"database":"Reactome","id":"R-HSA-69017","properties":[{"key":"PathwayName","value":"CDK-mediated phosphorylation and removal of Cdc6"}]},{"database":"Reactome","id":"R-HSA-69273","properties":[{"key":"PathwayName","value":"Cyclin A/B1/B2 associated events during G2/M transition"}]},{"database":"Reactome","id":"R-HSA-69478","properties":[{"key":"PathwayName","value":"G2/M DNA replication checkpoint"}]},{"database":"Reactome","id":"R-HSA-69563","properties":[{"key":"PathwayName","value":"p53-Dependent G1 DNA Damage Response"}]},{"database":"Reactome","id":"R-HSA-69656","properties":[{"key":"PathwayName","value":"Cyclin A:Cdk2-associated events at S phase entry"}]},{"database":"Reactome","id":"R-HSA-75035","properties":[{"key":"PathwayName","value":"Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex"}]},{"database":"SignaLink","id":"P20248","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"P20248","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000145386","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"890","properties":[{"key":"hits","value":"802 hits in 1170 CRISPR screens"}]},{"database":"CD-CODE","id":"8C2F96ED","properties":[{"key":"EntryName","value":"Centrosome"}]},{"database":"EvolutionaryTrace","id":"P20248","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"Cyclin_A2","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"890","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"P20248","properties":[{"key":"DevelopmentLevel","value":"Tchem"}]},{"database":"PRO","id":"PR:P20248","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 4"}]},{"database":"RNAct","id":"P20248","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000145386","properties":[{"key":"ExpressionPatterns","value":"Expressed in ventricular zone and 161 other cell types or tissues"}]},{"database":"GO","id":"GO:0097122","properties":[{"key":"GoTerm","value":"C:cyclin A2-CDK1 complex"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"1312467"}]},{"database":"GO","id":"GO:0097124","properties":[{"key":"GoTerm","value":"C:cyclin A2-CDK2 complex"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"1312467"}]},{"database":"GO","id":"GO:0000307","properties":[{"key":"GoTerm","value":"C:cyclin-dependent protein kinase holoenzyme complex"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"1312467"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"1312467"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0001939","properties":[{"key":"GoTerm","value":"C:female pronucleus"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0001940","properties":[{"key":"GoTerm","value":"C:male pronucleus"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0005815","properties":[{"key":"GoTerm","value":"C:microtubule organizing center"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"IDA:CAFA"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"8245034"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"1312467"}]},{"database":"GO","id":"GO:0016538","properties":[{"key":"GoTerm","value":"F:cyclin-dependent protein serine/threonine kinase regulator activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"1312467"}]},{"database":"GO","id":"GO:0019904","properties":[{"key":"GoTerm","value":"F:protein domain specific binding"},{"key":"GoEvidenceType","value":"IPI:CAFA"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"15024385"}]},{"database":"GO","id":"GO:0019901","properties":[{"key":"GoTerm","value":"F:protein kinase binding"},{"key":"GoEvidenceType","value":"IPI:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"1312467"}]},{"database":"GO","id":"GO:0031100","properties":[{"key":"GoTerm","value":"P:animal organ regeneration"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0044843","properties":[{"key":"GoTerm","value":"P:cell cycle G1/S phase transition"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"1312467"}]},{"database":"GO","id":"GO:0071314","properties":[{"key":"GoTerm","value":"P:cellular response to cocaine"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0071392","properties":[{"key":"GoTerm","value":"P:cellular response to estradiol stimulus"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0071456","properties":[{"key":"GoTerm","value":"P:cellular response to hypoxia"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:1990314","properties":[{"key":"GoTerm","value":"P:cellular response to insulin-like growth factor stimulus"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0044320","properties":[{"key":"GoTerm","value":"P:cellular response to leptin stimulus"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0071373","properties":[{"key":"GoTerm","value":"P:cellular response to luteinizing hormone stimulus"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0071732","properties":[{"key":"GoTerm","value":"P:cellular response to nitric oxide"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0036120","properties":[{"key":"GoTerm","value":"P:cellular response to platelet-derived growth factor stimulus"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0090102","properties":[{"key":"GoTerm","value":"P:cochlea development"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0000082","properties":[{"key":"GoTerm","value":"P:G1/S transition of mitotic cell cycle"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"1312467"}]},{"database":"GO","id":"GO:0000086","properties":[{"key":"GoTerm","value":"P:G2/M transition of mitotic cell cycle"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"1312467"}]},{"database":"GO","id":"GO:2000573","properties":[{"key":"GoTerm","value":"P:positive regulation of DNA biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0048146","properties":[{"key":"GoTerm","value":"P:positive regulation of fibroblast proliferation"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0043687","properties":[{"key":"GoTerm","value":"P:post-translational protein modification"},{"key":"GoEvidenceType","value":"IDA:CAFA"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11746698"}]},{"database":"GO","id":"GO:0007265","properties":[{"key":"GoTerm","value":"P:Ras protein signal transduction"},{"key":"GoEvidenceType","value":"IEP:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000270","source":"PubMed","id":"9054499"}]},{"database":"GO","id":"GO:0006275","properties":[{"key":"GoTerm","value":"P:regulation of DNA replication"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"17234884"}]},{"database":"GO","id":"GO:0033762","properties":[{"key":"GoTerm","value":"P:response to glucagon"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"CDD","id":"cd20561","properties":[{"key":"EntryName","value":"CYCLIN_CCNA2_rpt1"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd20564","properties":[{"key":"EntryName","value":"CYCLIN_CCNA2_rpt2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.472.10:FF:000037","properties":[{"key":"EntryName","value":"Cyclin-A2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.472.10","properties":[{"key":"EntryName","value":"Cyclin-like"},{"key":"MatchStatus","value":"2"}]},{"database":"IDEAL","id":"IID00032","properties":[{"key":"Description","value":"-"}]},{"database":"InterPro","id":"IPR039361","properties":[{"key":"EntryName","value":"Cyclin"}]},{"database":"InterPro","id":"IPR032447","properties":[{"key":"EntryName","value":"Cyclin-A_N"}]},{"database":"InterPro","id":"IPR013763","properties":[{"key":"EntryName","value":"Cyclin-like_dom"}]},{"database":"InterPro","id":"IPR036915","properties":[{"key":"EntryName","value":"Cyclin-like_sf"}]},{"database":"InterPro","id":"IPR046965","properties":[{"key":"EntryName","value":"Cyclin_A/B-like"}]},{"database":"InterPro","id":"IPR004367","properties":[{"key":"EntryName","value":"Cyclin_C-dom"}]},{"database":"InterPro","id":"IPR006671","properties":[{"key":"EntryName","value":"Cyclin_N"}]},{"database":"InterPro","id":"IPR048258","properties":[{"key":"EntryName","value":"Cyclins_cyclin-box"}]},{"database":"PANTHER","id":"PTHR10177","properties":[{"key":"EntryName","value":"CYCLINS"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02984","properties":[{"key":"EntryName","value":"Cyclin_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00134","properties":[{"key":"EntryName","value":"Cyclin_N"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF16500","properties":[{"key":"EntryName","value":"Cyclin_N2"},{"key":"MatchStatus","value":"1"}]},{"database":"PIRSF","id":"PIRSF001771","properties":[{"key":"EntryName","value":"Cyclin_A_B_D_E"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00385","properties":[{"key":"EntryName","value":"CYCLIN"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM01332","properties":[{"key":"EntryName","value":"Cyclin_C"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF47954","properties":[{"key":"EntryName","value":"Cyclin-like"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS00292","properties":[{"key":"EntryName","value":"CYCLINS"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MLGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRGLAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAESQKIEREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIILEDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL","length":432,"molWeight":48551,"crc64":"97763A2897DD35F4","md5":"779F6E3644B3EF745677D0BB11E602DB"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":2,"INTERACTION":7,"SUBCELLULAR LOCATION":1,"DEVELOPMENTAL STAGE":1,"PTM":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Region":2,"Modified residue":3,"Natural variant":1,"Sequence conflict":1,"Turn":4,"Beta strand":6,"Helix":23},"uniParcId":"UPI000013D9E8"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8T204","uniProtkbId":"A0ACI8T204_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000590857.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00039941"}],"value":"CCN family member 1"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00042351"}],"value":"Cellular communication network factor 1"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00042204"}],"value":"Protein CYR61"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000590857.1"}],"value":"CCN1"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004613"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008125"}],"value":"Belongs to the CCN family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00039"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":24,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":262,"modifier":"EXACT"}},"description":"CCN family member 1","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5051404040"},{"type":"Domain","location":{"start":{"value":22,"modifier":"EXACT"},"end":{"value":94,"modifier":"EXACT"}},"description":"IGFBP N-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51323"}]},{"type":"Domain","location":{"start":{"value":167,"modifier":"EXACT"},"end":{"value":241,"modifier":"EXACT"}},"description":"CTCK","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS01225"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8T204"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8T204"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000590857.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000590857.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16710414","citationType":"journal article","authors":["Gregory S.G.","Barlow K.F.","McLay K.E.","Kaul R.","Swarbreck D.","Dunham A.","Scott C.E.","Howe K.L.","Woodfine K.","Spencer C.C.","Jones M.C.","Gillson C.","Searle S.","Zhou Y.","Kokocinski F.","McDonald L.","Evans R.","Phillips K.","Atkinson A.","Cooper R.","Jones C.","Hall R.E.","Andrews T.D.","Lloyd C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Anderson F.","Andrew R.W.","Ashwell R.I.","Aubin K.","Babbage A.K.","Bagguley C.L.","Bailey J.","Beasley H.","Bethel G.","Bird C.P.","Bray-Allen S.","Brown J.Y.","Brown A.J.","Buckley D.","Burton J.","Bye J.","Carder C.","Chapman J.C.","Clark S.Y.","Clarke G.","Clee C.","Cobley V.","Collier R.E.","Corby N.","Coville G.J.","Davies J.","Deadman R.","Dunn M.","Earthrowl M.","Ellington A.G.","Errington H.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Gay L.","Ghori M.R.","Gibson R.","Gilby L.M.","Gillett W.","Glithero R.J.","Grafham D.V.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Hammond S.","Harrison E.S.","Hart E.","Haugen E.","Heath P.D.","Holmes S.","Holt K.","Howden P.J.","Hunt A.R.","Hunt S.E.","Hunter G.","Isherwood J.","James R.","Johnson C.","Johnson D.","Joy A.","Kay M.","Kershaw J.K.","Kibukawa M.","Kimberley A.M.","King A.","Knights A.J.","Lad H.","Laird G.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Loveland J.","Lovell J.","Lush M.J.","Lyne R.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","Matthews N.S.","McLaren S.","Milne S.","Mistry S.","Moore M.J.","Nickerson T.","O'Dell C.N.","Oliver K.","Palmeiri A.","Palmer S.A.","Parker A.","Patel D.","Pearce A.V.","Peck A.I.","Pelan S.","Phelps K.","Phillimore B.J.","Plumb R.","Rajan J.","Raymond C.","Rouse G.","Saenphimmachak C.","Sehra H.K.","Sheridan E.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.","Steward C.","Subramanian S.","Sycamore N.","Tracey A.","Tromans A.","Van Helmond Z.","Wall M.","Wallis J.M.","White S.","Whitehead S.L.","Wilkinson J.E.","Willey D.L.","Williams H.","Wilming L.","Wray P.W.","Wu Z.","Coulson A.","Vaudin M.","Sulston J.E.","Durbin R.","Hubbard T.","Wooster R.","Dunham I.","Carter N.P.","McVean G.","Ross M.T.","Harrow J.","Olson M.V.","Beck S.","Rogers J.","Bentley D.R.","Banerjee R.","Bryant S.P.","Burford D.C.","Burrill W.D.","Clegg S.M.","Dhami P.","Dovey O.","Faulkner L.M.","Gribble S.M.","Langford C.F.","Pandian R.D.","Porter K.M.","Prigmore E."],"citationCrossReferences":[{"database":"PubMed","id":"16710414"},{"database":"DOI","id":"10.1038/nature04727"}],"title":"The DNA sequence and biological annotation of human chromosome 1.","publicationDate":"2006","journal":"Nature","firstPage":"315","lastPage":"321","volume":"441"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000590857.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000590857.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC092807","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000920798.1","properties":[{"key":"ProteinId","value":"ENSP00000590857.1"},{"key":"GeneId","value":"ENSG00000142871.19"}]},{"database":"HGNC","id":"HGNC:2654","properties":[{"key":"GeneName","value":"CCN1"}]},{"database":"OpenTargets","id":"ENSG00000142871","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000155151","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"FunFam","id":"2.20.100.10:FF:000038","properties":[{"key":"EntryName","value":"CYR61 isoform 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.20.100.10","properties":[{"key":"EntryName","value":"Thrombospondin type-1 (TSP1) repeat"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR050941","properties":[{"key":"EntryName","value":"CCN"}]},{"database":"InterPro","id":"IPR006207","properties":[{"key":"EntryName","value":"Cys_knot_C"}]},{"database":"InterPro","id":"IPR006208","properties":[{"key":"EntryName","value":"Glyco_hormone_CN"}]},{"database":"InterPro","id":"IPR009030","properties":[{"key":"EntryName","value":"Growth_fac_rcpt_cys_sf"}]},{"database":"InterPro","id":"IPR000867","properties":[{"key":"EntryName","value":"IGFBP-like"}]},{"database":"InterPro","id":"IPR017891","properties":[{"key":"EntryName","value":"Insulin_GF-bd_Cys-rich_CS"}]},{"database":"InterPro","id":"IPR043973","properties":[{"key":"EntryName","value":"TSP1_CCN"}]},{"database":"InterPro","id":"IPR000884","properties":[{"key":"EntryName","value":"TSP1_rpt"}]},{"database":"InterPro","id":"IPR036383","properties":[{"key":"EntryName","value":"TSP1_rpt_sf"}]},{"database":"PANTHER","id":"PTHR11348:SF18","properties":[{"key":"EntryName","value":"CCN FAMILY MEMBER 1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11348","properties":[{"key":"EntryName","value":"CONNECTIVE TISSUE GROWTH FACTOR-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00007","properties":[{"key":"EntryName","value":"Cys_knot"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00219","properties":[{"key":"EntryName","value":"IGFBP"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF19035","properties":[{"key":"EntryName","value":"TSP1_CCN"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00041","properties":[{"key":"EntryName","value":"CT"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00121","properties":[{"key":"EntryName","value":"IB"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00209","properties":[{"key":"EntryName","value":"TSP1"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57184","properties":[{"key":"EntryName","value":"Growth factor receptor domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF82895","properties":[{"key":"EntryName","value":"TSP-1 type 1 repeat"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01185","properties":[{"key":"EntryName","value":"CTCK_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01225","properties":[{"key":"EntryName","value":"CTCK_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00222","properties":[{"key":"EntryName","value":"IGFBP_N_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51323","properties":[{"key":"EntryName","value":"IGFBP_N_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50092","properties":[{"key":"EntryName","value":"TSP1"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSSRIARALALVVTLLHLTRLALSTCPAACHCPLEAPKCAPGVGLVRDGCGCCKVCAKQLNEDCSKTQPCDHTKGLECNFGASSTALKGICRVFGMEPRILYNPLQGQKCIVQTTSWSQCSKTCGTGISTRVTNDNPECRLVKETRICEVRPCGQPVYSSLKKGKKCSKTKKSPEPVRFTYAGCLSVKKYRPKYCGSCVDGRCCTPQLTRTVKMRFRCEDGETFSKNVMMIQSCKCNYNCPHANEAAFPFYRLFNDIHKFRD","length":262,"molWeight":29015,"crc64":"CF69DECBD7E58CFC","md5":"AE96B2D45DA5EFB0CE0B9C68FAA95B7F"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":2},"uniParcId":"UPI0003E72020"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8VKT2","uniProtkbId":"A0ACI8VKT2_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000638476.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00039941"}],"value":"CCN family member 1"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00042351"}],"value":"Cellular communication network factor 1"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00080444"}],"value":"Cysteine-rich angiogenic inducer 61"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00042204"}],"value":"Protein CYR61"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000638476.1"}],"value":"CCN1"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004613"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008125"}],"value":"Belongs to the CCN family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00039"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":24,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":409,"modifier":"EXACT"}},"description":"CCN family member 1","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5051392792"},{"type":"Domain","location":{"start":{"value":22,"modifier":"EXACT"},"end":{"value":94,"modifier":"EXACT"}},"description":"IGFBP N-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51323"}]},{"type":"Domain","location":{"start":{"value":126,"modifier":"EXACT"},"end":{"value":192,"modifier":"EXACT"}},"description":"VWFC","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50184"}]},{"type":"Domain","location":{"start":{"value":314,"modifier":"EXACT"},"end":{"value":388,"modifier":"EXACT"}},"description":"CTCK","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS01225"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023183"}],"id":"KW-0340","category":"Molecular function","name":"Growth factor binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8VKT2"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8VKT2"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000638476.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000638476.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16710414","citationType":"journal article","authors":["Gregory S.G.","Barlow K.F.","McLay K.E.","Kaul R.","Swarbreck D.","Dunham A.","Scott C.E.","Howe K.L.","Woodfine K.","Spencer C.C.","Jones M.C.","Gillson C.","Searle S.","Zhou Y.","Kokocinski F.","McDonald L.","Evans R.","Phillips K.","Atkinson A.","Cooper R.","Jones C.","Hall R.E.","Andrews T.D.","Lloyd C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Anderson F.","Andrew R.W.","Ashwell R.I.","Aubin K.","Babbage A.K.","Bagguley C.L.","Bailey J.","Beasley H.","Bethel G.","Bird C.P.","Bray-Allen S.","Brown J.Y.","Brown A.J.","Buckley D.","Burton J.","Bye J.","Carder C.","Chapman J.C.","Clark S.Y.","Clarke G.","Clee C.","Cobley V.","Collier R.E.","Corby N.","Coville G.J.","Davies J.","Deadman R.","Dunn M.","Earthrowl M.","Ellington A.G.","Errington H.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Gay L.","Ghori M.R.","Gibson R.","Gilby L.M.","Gillett W.","Glithero R.J.","Grafham D.V.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Hammond S.","Harrison E.S.","Hart E.","Haugen E.","Heath P.D.","Holmes S.","Holt K.","Howden P.J.","Hunt A.R.","Hunt S.E.","Hunter G.","Isherwood J.","James R.","Johnson C.","Johnson D.","Joy A.","Kay M.","Kershaw J.K.","Kibukawa M.","Kimberley A.M.","King A.","Knights A.J.","Lad H.","Laird G.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Loveland J.","Lovell J.","Lush M.J.","Lyne R.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","Matthews N.S.","McLaren S.","Milne S.","Mistry S.","Moore M.J.","Nickerson T.","O'Dell C.N.","Oliver K.","Palmeiri A.","Palmer S.A.","Parker A.","Patel D.","Pearce A.V.","Peck A.I.","Pelan S.","Phelps K.","Phillimore B.J.","Plumb R.","Rajan J.","Raymond C.","Rouse G.","Saenphimmachak C.","Sehra H.K.","Sheridan E.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.","Steward C.","Subramanian S.","Sycamore N.","Tracey A.","Tromans A.","Van Helmond Z.","Wall M.","Wallis J.M.","White S.","Whitehead S.L.","Wilkinson J.E.","Willey D.L.","Williams H.","Wilming L.","Wray P.W.","Wu Z.","Coulson A.","Vaudin M.","Sulston J.E.","Durbin R.","Hubbard T.","Wooster R.","Dunham I.","Carter N.P.","McVean G.","Ross M.T.","Harrow J.","Olson M.V.","Beck S.","Rogers J.","Bentley D.R.","Banerjee R.","Bryant S.P.","Burford D.C.","Burrill W.D.","Clegg S.M.","Dhami P.","Dovey O.","Faulkner L.M.","Gribble S.M.","Langford C.F.","Pandian R.D.","Porter K.M.","Prigmore E."],"citationCrossReferences":[{"database":"PubMed","id":"16710414"},{"database":"DOI","id":"10.1038/nature04727"}],"title":"The DNA sequence and biological annotation of human chromosome 1.","publicationDate":"2006","journal":"Nature","firstPage":"315","lastPage":"321","volume":"441"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000638476.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000638476.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC092807","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000968417.1","properties":[{"key":"ProteinId","value":"ENSP00000638476.1"},{"key":"GeneId","value":"ENSG00000142871.19"}]},{"database":"HGNC","id":"HGNC:2654","properties":[{"key":"GeneName","value":"CCN1"}]},{"database":"OpenTargets","id":"ENSG00000142871","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000155151","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"FunFam","id":"2.10.70.10:FF:000015","properties":[{"key":"EntryName","value":"CYR61 isoform 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.20.100.10:FF:000038","properties":[{"key":"EntryName","value":"CYR61 isoform 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.10.70.10","properties":[{"key":"EntryName","value":"Complement Module, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.20.100.10","properties":[{"key":"EntryName","value":"Thrombospondin type-1 (TSP1) repeat"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR050941","properties":[{"key":"EntryName","value":"CCN"}]},{"database":"InterPro","id":"IPR006207","properties":[{"key":"EntryName","value":"Cys_knot_C"}]},{"database":"InterPro","id":"IPR006208","properties":[{"key":"EntryName","value":"Glyco_hormone_CN"}]},{"database":"InterPro","id":"IPR009030","properties":[{"key":"EntryName","value":"Growth_fac_rcpt_cys_sf"}]},{"database":"InterPro","id":"IPR000867","properties":[{"key":"EntryName","value":"IGFBP-like"}]},{"database":"InterPro","id":"IPR012395","properties":[{"key":"EntryName","value":"IGFBP_CNN"}]},{"database":"InterPro","id":"IPR017891","properties":[{"key":"EntryName","value":"Insulin_GF-bd_Cys-rich_CS"}]},{"database":"InterPro","id":"IPR043973","properties":[{"key":"EntryName","value":"TSP1_CCN"}]},{"database":"InterPro","id":"IPR000884","properties":[{"key":"EntryName","value":"TSP1_rpt"}]},{"database":"InterPro","id":"IPR036383","properties":[{"key":"EntryName","value":"TSP1_rpt_sf"}]},{"database":"InterPro","id":"IPR001007","properties":[{"key":"EntryName","value":"VWF_dom"}]},{"database":"PANTHER","id":"PTHR11348:SF18","properties":[{"key":"EntryName","value":"CCN FAMILY MEMBER 1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11348","properties":[{"key":"EntryName","value":"CONNECTIVE TISSUE GROWTH FACTOR-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00007","properties":[{"key":"EntryName","value":"Cys_knot"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00219","properties":[{"key":"EntryName","value":"IGFBP"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF19035","properties":[{"key":"EntryName","value":"TSP1_CCN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00093","properties":[{"key":"EntryName","value":"VWC"},{"key":"MatchStatus","value":"1"}]},{"database":"PIRSF","id":"PIRSF036495","properties":[{"key":"EntryName","value":"IGFBP_rP_CNN"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00041","properties":[{"key":"EntryName","value":"CT"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00121","properties":[{"key":"EntryName","value":"IB"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00209","properties":[{"key":"EntryName","value":"TSP1"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00214","properties":[{"key":"EntryName","value":"VWC"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57603","properties":[{"key":"EntryName","value":"FnI-like domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57184","properties":[{"key":"EntryName","value":"Growth factor receptor domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF82895","properties":[{"key":"EntryName","value":"TSP-1 type 1 repeat"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01185","properties":[{"key":"EntryName","value":"CTCK_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01225","properties":[{"key":"EntryName","value":"CTCK_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00222","properties":[{"key":"EntryName","value":"IGFBP_N_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51323","properties":[{"key":"EntryName","value":"IGFBP_N_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50092","properties":[{"key":"EntryName","value":"TSP1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01208","properties":[{"key":"EntryName","value":"VWFC_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50184","properties":[{"key":"EntryName","value":"VWFC_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSSRIARALALVVTLLHLTRLALSTCPAACHCPLEAPKCAPGVGLVRDGCGCCKVCAKQLNEDCSKTQPCDHTKGLECNFGASSTALKGICRAENMYEFQAVVWNLNFIPFYLSLLVIFAAQSEGRPCEYNSRIYQNGESFQPNCKHQCTCIDGAVGCIPLCPQELSLPNLGCPNPRLVKVTGQCCEEWVCDEDSIKDPMEDQDGLLGKELGFDASEVELTRNNELIAVGKGSSLKRLPVFGMEPRILYNPLQGQKCIVQTTSWSQCSKTCGTGISTRVTNDNPECRLVKETRICEVRPCGQPVYSSLKKGKKCSKTKKSPEPVRFTYAGCLSVKKYRPKYCGSCVDGRCCTPQLTRTVKMRFRCEDGETFSKNVMMIQSCKCNYNCPHANEAAFPFYRLFNDIHKFRD","length":409,"molWeight":45362,"crc64":"DCC849C1619CBFE6","md5":"D1CF7DE97DBA3D8A945F952D2CD088CA"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":3},"uniParcId":"UPI0040316F77"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8QFB6","uniProtkbId":"A0ACI8QFB6_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000536095.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00039941"}],"value":"CCN family member 1"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00042351"}],"value":"Cellular communication network factor 1"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00080444"}],"value":"Cysteine-rich angiogenic inducer 61"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00042204"}],"value":"Protein CYR61"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000536095.1"}],"value":"CCN1"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004613"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008125"}],"value":"Belongs to the CCN family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00039"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":24,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":380,"modifier":"EXACT"}},"description":"CCN family member 1","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5051271206"},{"type":"Domain","location":{"start":{"value":22,"modifier":"EXACT"},"end":{"value":94,"modifier":"EXACT"}},"description":"IGFBP N-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51323"}]},{"type":"Domain","location":{"start":{"value":98,"modifier":"EXACT"},"end":{"value":164,"modifier":"EXACT"}},"description":"VWFC","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50184"}]},{"type":"Domain","location":{"start":{"value":285,"modifier":"EXACT"},"end":{"value":359,"modifier":"EXACT"}},"description":"CTCK","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS01225"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023183"}],"id":"KW-0340","category":"Molecular function","name":"Growth factor binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8QFB6"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8QFB6"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000536095.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000536095.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16710414","citationType":"journal article","authors":["Gregory S.G.","Barlow K.F.","McLay K.E.","Kaul R.","Swarbreck D.","Dunham A.","Scott C.E.","Howe K.L.","Woodfine K.","Spencer C.C.","Jones M.C.","Gillson C.","Searle S.","Zhou Y.","Kokocinski F.","McDonald L.","Evans R.","Phillips K.","Atkinson A.","Cooper R.","Jones C.","Hall R.E.","Andrews T.D.","Lloyd C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Anderson F.","Andrew R.W.","Ashwell R.I.","Aubin K.","Babbage A.K.","Bagguley C.L.","Bailey J.","Beasley H.","Bethel G.","Bird C.P.","Bray-Allen S.","Brown J.Y.","Brown A.J.","Buckley D.","Burton J.","Bye J.","Carder C.","Chapman J.C.","Clark S.Y.","Clarke G.","Clee C.","Cobley V.","Collier R.E.","Corby N.","Coville G.J.","Davies J.","Deadman R.","Dunn M.","Earthrowl M.","Ellington A.G.","Errington H.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Gay L.","Ghori M.R.","Gibson R.","Gilby L.M.","Gillett W.","Glithero R.J.","Grafham D.V.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Hammond S.","Harrison E.S.","Hart E.","Haugen E.","Heath P.D.","Holmes S.","Holt K.","Howden P.J.","Hunt A.R.","Hunt S.E.","Hunter G.","Isherwood J.","James R.","Johnson C.","Johnson D.","Joy A.","Kay M.","Kershaw J.K.","Kibukawa M.","Kimberley A.M.","King A.","Knights A.J.","Lad H.","Laird G.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Loveland J.","Lovell J.","Lush M.J.","Lyne R.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","Matthews N.S.","McLaren S.","Milne S.","Mistry S.","Moore M.J.","Nickerson T.","O'Dell C.N.","Oliver K.","Palmeiri A.","Palmer S.A.","Parker A.","Patel D.","Pearce A.V.","Peck A.I.","Pelan S.","Phelps K.","Phillimore B.J.","Plumb R.","Rajan J.","Raymond C.","Rouse G.","Saenphimmachak C.","Sehra H.K.","Sheridan E.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.","Steward C.","Subramanian S.","Sycamore N.","Tracey A.","Tromans A.","Van Helmond Z.","Wall M.","Wallis J.M.","White S.","Whitehead S.L.","Wilkinson J.E.","Willey D.L.","Williams H.","Wilming L.","Wray P.W.","Wu Z.","Coulson A.","Vaudin M.","Sulston J.E.","Durbin R.","Hubbard T.","Wooster R.","Dunham I.","Carter N.P.","McVean G.","Ross M.T.","Harrow J.","Olson M.V.","Beck S.","Rogers J.","Bentley D.R.","Banerjee R.","Bryant S.P.","Burford D.C.","Burrill W.D.","Clegg S.M.","Dhami P.","Dovey O.","Faulkner L.M.","Gribble S.M.","Langford C.F.","Pandian R.D.","Porter K.M.","Prigmore E."],"citationCrossReferences":[{"database":"PubMed","id":"16710414"},{"database":"DOI","id":"10.1038/nature04727"}],"title":"The DNA sequence and biological annotation of human chromosome 1.","publicationDate":"2006","journal":"Nature","firstPage":"315","lastPage":"321","volume":"441"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000536095.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000536095.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC092807","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000866036.1","properties":[{"key":"ProteinId","value":"ENSP00000536095.1"},{"key":"GeneId","value":"ENSG00000142871.19"}]},{"database":"HGNC","id":"HGNC:2654","properties":[{"key":"GeneName","value":"CCN1"}]},{"database":"OpenTargets","id":"ENSG00000142871","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000155151","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"FunFam","id":"2.10.70.10:FF:000015","properties":[{"key":"EntryName","value":"CYR61 isoform 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.20.100.10:FF:000038","properties":[{"key":"EntryName","value":"CYR61 isoform 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.10.70.10","properties":[{"key":"EntryName","value":"Complement Module, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.20.100.10","properties":[{"key":"EntryName","value":"Thrombospondin type-1 (TSP1) repeat"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR050941","properties":[{"key":"EntryName","value":"CCN"}]},{"database":"InterPro","id":"IPR006207","properties":[{"key":"EntryName","value":"Cys_knot_C"}]},{"database":"InterPro","id":"IPR006208","properties":[{"key":"EntryName","value":"Glyco_hormone_CN"}]},{"database":"InterPro","id":"IPR009030","properties":[{"key":"EntryName","value":"Growth_fac_rcpt_cys_sf"}]},{"database":"InterPro","id":"IPR000867","properties":[{"key":"EntryName","value":"IGFBP-like"}]},{"database":"InterPro","id":"IPR012395","properties":[{"key":"EntryName","value":"IGFBP_CNN"}]},{"database":"InterPro","id":"IPR017891","properties":[{"key":"EntryName","value":"Insulin_GF-bd_Cys-rich_CS"}]},{"database":"InterPro","id":"IPR043973","properties":[{"key":"EntryName","value":"TSP1_CCN"}]},{"database":"InterPro","id":"IPR000884","properties":[{"key":"EntryName","value":"TSP1_rpt"}]},{"database":"InterPro","id":"IPR036383","properties":[{"key":"EntryName","value":"TSP1_rpt_sf"}]},{"database":"InterPro","id":"IPR001007","properties":[{"key":"EntryName","value":"VWF_dom"}]},{"database":"PANTHER","id":"PTHR11348:SF18","properties":[{"key":"EntryName","value":"CCN FAMILY MEMBER 1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11348","properties":[{"key":"EntryName","value":"CONNECTIVE TISSUE GROWTH FACTOR-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00007","properties":[{"key":"EntryName","value":"Cys_knot"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00219","properties":[{"key":"EntryName","value":"IGFBP"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF19035","properties":[{"key":"EntryName","value":"TSP1_CCN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00093","properties":[{"key":"EntryName","value":"VWC"},{"key":"MatchStatus","value":"1"}]},{"database":"PIRSF","id":"PIRSF036495","properties":[{"key":"EntryName","value":"IGFBP_rP_CNN"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00041","properties":[{"key":"EntryName","value":"CT"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00121","properties":[{"key":"EntryName","value":"IB"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00209","properties":[{"key":"EntryName","value":"TSP1"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00214","properties":[{"key":"EntryName","value":"VWC"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57603","properties":[{"key":"EntryName","value":"FnI-like domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57184","properties":[{"key":"EntryName","value":"Growth factor receptor domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF82895","properties":[{"key":"EntryName","value":"TSP-1 type 1 repeat"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01185","properties":[{"key":"EntryName","value":"CTCK_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01225","properties":[{"key":"EntryName","value":"CTCK_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00222","properties":[{"key":"EntryName","value":"IGFBP_N_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51323","properties":[{"key":"EntryName","value":"IGFBP_N_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50092","properties":[{"key":"EntryName","value":"TSP1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01208","properties":[{"key":"EntryName","value":"VWFC_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50184","properties":[{"key":"EntryName","value":"VWFC_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSSRIARALALVVTLLHLTRLALSTCPAACHCPLEAPKCAPGVGLVRDGCGCCKVCAKQLNEDCSKTQPCDHTKGLECNFGASSTALKGICRAQSEGRPCEYNSRIYQNGESFQPNCKHQCTCIDGAVGCIPLCPQELSLPNLGCPNPRLVKVTGQCCEEWVCDEDSIKDPMEDQDGLLGKELGFDASEVELTRNNELIAVGKGSSLKRLPVFGMEPRILYNPLQGQKCIVQTTSWSQCSKTCGTGISTRVTNDNPECRLVKETRICEVRPCGQPVYSSLKGKKCSKTKKSPEPVRFTYAGCLSVKKYRPKYCGSCVDGRCCTPQLTRTVKMRFRCEDGETFSKNVMMIQSCKCNYNCPHANEAAFPFYRLFNDIHKFRD","length":380,"molWeight":41898,"crc64":"E3164C55AFD9784F","md5":"5B9315BC27694985EF994A993A329ECF"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":3},"uniParcId":"UPI0040314C99"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8T1J4","uniProtkbId":"A0ACI8T1J4_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000590856.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00039941"}],"value":"CCN family member 1"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00042351"}],"value":"Cellular communication network factor 1"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00042204"}],"value":"Protein CYR61"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000590856.1"}],"value":"CCN1"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004613"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008125"}],"value":"Belongs to the CCN family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00039"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":24,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":261,"modifier":"EXACT"}},"description":"CCN family member 1","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5051210672"},{"type":"Domain","location":{"start":{"value":22,"modifier":"EXACT"},"end":{"value":94,"modifier":"EXACT"}},"description":"IGFBP N-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51323"}]},{"type":"Domain","location":{"start":{"value":166,"modifier":"EXACT"},"end":{"value":240,"modifier":"EXACT"}},"description":"CTCK","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS01225"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8T1J4"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8T1J4"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000590856.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000590856.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16710414","citationType":"journal article","authors":["Gregory S.G.","Barlow K.F.","McLay K.E.","Kaul R.","Swarbreck D.","Dunham A.","Scott C.E.","Howe K.L.","Woodfine K.","Spencer C.C.","Jones M.C.","Gillson C.","Searle S.","Zhou Y.","Kokocinski F.","McDonald L.","Evans R.","Phillips K.","Atkinson A.","Cooper R.","Jones C.","Hall R.E.","Andrews T.D.","Lloyd C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Anderson F.","Andrew R.W.","Ashwell R.I.","Aubin K.","Babbage A.K.","Bagguley C.L.","Bailey J.","Beasley H.","Bethel G.","Bird C.P.","Bray-Allen S.","Brown J.Y.","Brown A.J.","Buckley D.","Burton J.","Bye J.","Carder C.","Chapman J.C.","Clark S.Y.","Clarke G.","Clee C.","Cobley V.","Collier R.E.","Corby N.","Coville G.J.","Davies J.","Deadman R.","Dunn M.","Earthrowl M.","Ellington A.G.","Errington H.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Gay L.","Ghori M.R.","Gibson R.","Gilby L.M.","Gillett W.","Glithero R.J.","Grafham D.V.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Hammond S.","Harrison E.S.","Hart E.","Haugen E.","Heath P.D.","Holmes S.","Holt K.","Howden P.J.","Hunt A.R.","Hunt S.E.","Hunter G.","Isherwood J.","James R.","Johnson C.","Johnson D.","Joy A.","Kay M.","Kershaw J.K.","Kibukawa M.","Kimberley A.M.","King A.","Knights A.J.","Lad H.","Laird G.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Loveland J.","Lovell J.","Lush M.J.","Lyne R.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","Matthews N.S.","McLaren S.","Milne S.","Mistry S.","Moore M.J.","Nickerson T.","O'Dell C.N.","Oliver K.","Palmeiri A.","Palmer S.A.","Parker A.","Patel D.","Pearce A.V.","Peck A.I.","Pelan S.","Phelps K.","Phillimore B.J.","Plumb R.","Rajan J.","Raymond C.","Rouse G.","Saenphimmachak C.","Sehra H.K.","Sheridan E.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.","Steward C.","Subramanian S.","Sycamore N.","Tracey A.","Tromans A.","Van Helmond Z.","Wall M.","Wallis J.M.","White S.","Whitehead S.L.","Wilkinson J.E.","Willey D.L.","Williams H.","Wilming L.","Wray P.W.","Wu Z.","Coulson A.","Vaudin M.","Sulston J.E.","Durbin R.","Hubbard T.","Wooster R.","Dunham I.","Carter N.P.","McVean G.","Ross M.T.","Harrow J.","Olson M.V.","Beck S.","Rogers J.","Bentley D.R.","Banerjee R.","Bryant S.P.","Burford D.C.","Burrill W.D.","Clegg S.M.","Dhami P.","Dovey O.","Faulkner L.M.","Gribble S.M.","Langford C.F.","Pandian R.D.","Porter K.M.","Prigmore E."],"citationCrossReferences":[{"database":"PubMed","id":"16710414"},{"database":"DOI","id":"10.1038/nature04727"}],"title":"The DNA sequence and biological annotation of human chromosome 1.","publicationDate":"2006","journal":"Nature","firstPage":"315","lastPage":"321","volume":"441"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000590856.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000590856.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC092807","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000920797.1","properties":[{"key":"ProteinId","value":"ENSP00000590856.1"},{"key":"GeneId","value":"ENSG00000142871.19"}]},{"database":"HGNC","id":"HGNC:2654","properties":[{"key":"GeneName","value":"CCN1"}]},{"database":"OpenTargets","id":"ENSG00000142871","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000155151","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"FunFam","id":"2.20.100.10:FF:000038","properties":[{"key":"EntryName","value":"CYR61 isoform 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.20.100.10","properties":[{"key":"EntryName","value":"Thrombospondin type-1 (TSP1) repeat"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR050941","properties":[{"key":"EntryName","value":"CCN"}]},{"database":"InterPro","id":"IPR006207","properties":[{"key":"EntryName","value":"Cys_knot_C"}]},{"database":"InterPro","id":"IPR006208","properties":[{"key":"EntryName","value":"Glyco_hormone_CN"}]},{"database":"InterPro","id":"IPR009030","properties":[{"key":"EntryName","value":"Growth_fac_rcpt_cys_sf"}]},{"database":"InterPro","id":"IPR000867","properties":[{"key":"EntryName","value":"IGFBP-like"}]},{"database":"InterPro","id":"IPR017891","properties":[{"key":"EntryName","value":"Insulin_GF-bd_Cys-rich_CS"}]},{"database":"InterPro","id":"IPR043973","properties":[{"key":"EntryName","value":"TSP1_CCN"}]},{"database":"InterPro","id":"IPR000884","properties":[{"key":"EntryName","value":"TSP1_rpt"}]},{"database":"InterPro","id":"IPR036383","properties":[{"key":"EntryName","value":"TSP1_rpt_sf"}]},{"database":"PANTHER","id":"PTHR11348:SF18","properties":[{"key":"EntryName","value":"CCN FAMILY MEMBER 1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11348","properties":[{"key":"EntryName","value":"CONNECTIVE TISSUE GROWTH FACTOR-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00007","properties":[{"key":"EntryName","value":"Cys_knot"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00219","properties":[{"key":"EntryName","value":"IGFBP"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF19035","properties":[{"key":"EntryName","value":"TSP1_CCN"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00041","properties":[{"key":"EntryName","value":"CT"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00121","properties":[{"key":"EntryName","value":"IB"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00209","properties":[{"key":"EntryName","value":"TSP1"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57184","properties":[{"key":"EntryName","value":"Growth factor receptor domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF82895","properties":[{"key":"EntryName","value":"TSP-1 type 1 repeat"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01185","properties":[{"key":"EntryName","value":"CTCK_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01225","properties":[{"key":"EntryName","value":"CTCK_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00222","properties":[{"key":"EntryName","value":"IGFBP_N_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51323","properties":[{"key":"EntryName","value":"IGFBP_N_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50092","properties":[{"key":"EntryName","value":"TSP1"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSSRIARALALVVTLLHLTRLALSTCPAACHCPLEAPKCAPGVGLVRDGCGCCKVCAKQLNEDCSKTQPCDHTKGLECNFGASSTALKGICRVFGMEPRILYNPLQGQKCIVQTTSWSQCSKTCGTGISTRVTNDNPECRLVKETRICEVRPCGQPVYSSLKGKKCSKTKKSPEPVRFTYAGCLSVKKYRPKYCGSCVDGRCCTPQLTRTVKMRFRCEDGETFSKNVMMIQSCKCNYNCPHANEAAFPFYRLFNDIHKFRD","length":261,"molWeight":28887,"crc64":"211B1B85C6F53569","md5":"B26FAA75C78F734936C3BF256FD4D7E3"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":2},"uniParcId":"UPI004031B4AC"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A6Q8PGQ1","uniProtkbId":"A0A6Q8PGQ1_HUMAN","entryAudit":{"firstPublicDate":"2020-12-02","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2020-12-02","entryVersion":24,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000502303.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000502303.1"}],"value":"Cellular communication network factor 1"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000502303.1"}],"value":"CCN1"}}],"features":[{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":59,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":48,"modifier":"EXACT"},"end":{"value":59,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000502303.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000502303.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000502303.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16710414","citationType":"journal article","authors":["Gregory S.G.","Barlow K.F.","McLay K.E.","Kaul R.","Swarbreck D.","Dunham A.","Scott C.E.","Howe K.L.","Woodfine K.","Spencer C.C.","Jones M.C.","Gillson C.","Searle S.","Zhou Y.","Kokocinski F.","McDonald L.","Evans R.","Phillips K.","Atkinson A.","Cooper R.","Jones C.","Hall R.E.","Andrews T.D.","Lloyd C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Anderson F.","Andrew R.W.","Ashwell R.I.","Aubin K.","Babbage A.K.","Bagguley C.L.","Bailey J.","Beasley H.","Bethel G.","Bird C.P.","Bray-Allen S.","Brown J.Y.","Brown A.J.","Buckley D.","Burton J.","Bye J.","Carder C.","Chapman J.C.","Clark S.Y.","Clarke G.","Clee C.","Cobley V.","Collier R.E.","Corby N.","Coville G.J.","Davies J.","Deadman R.","Dunn M.","Earthrowl M.","Ellington A.G.","Errington H.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Gay L.","Ghori M.R.","Gibson R.","Gilby L.M.","Gillett W.","Glithero R.J.","Grafham D.V.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Hammond S.","Harrison E.S.","Hart E.","Haugen E.","Heath P.D.","Holmes S.","Holt K.","Howden P.J.","Hunt A.R.","Hunt S.E.","Hunter G.","Isherwood J.","James R.","Johnson C.","Johnson D.","Joy A.","Kay M.","Kershaw J.K.","Kibukawa M.","Kimberley A.M.","King A.","Knights A.J.","Lad H.","Laird G.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Loveland J.","Lovell J.","Lush M.J.","Lyne R.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","Matthews N.S.","McLaren S.","Milne S.","Mistry S.","Moore M.J.","Nickerson T.","O'Dell C.N.","Oliver K.","Palmeiri A.","Palmer S.A.","Parker A.","Patel D.","Pearce A.V.","Peck A.I.","Pelan S.","Phelps K.","Phillimore B.J.","Plumb R.","Rajan J.","Raymond C.","Rouse G.","Saenphimmachak C.","Sehra H.K.","Sheridan E.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.","Steward C.","Subramanian S.","Sycamore N.","Tracey A.","Tromans A.","Van Helmond Z.","Wall M.","Wallis J.M.","White S.","Whitehead S.L.","Wilkinson J.E.","Willey D.L.","Williams H.","Wilming L.","Wray P.W.","Wu Z.","Coulson A.","Vaudin M.","Sulston J.E.","Durbin R.","Hubbard T.","Wooster R.","Dunham I.","Carter N.P.","McVean G.","Ross M.T.","Harrow J.","Olson M.V.","Beck S.","Rogers J.","Bentley D.R.","Banerjee R.","Bryant S.P.","Burford D.C.","Burrill W.D.","Clegg S.M.","Dhami P.","Dovey O.","Faulkner L.M.","Gribble S.M.","Langford C.F.","Pandian R.D.","Porter K.M.","Prigmore E."],"citationCrossReferences":[{"database":"PubMed","id":"16710414"},{"database":"DOI","id":"10.1038/nature04727"}],"title":"The DNA sequence and biological annotation of human chromosome 1.","publicationDate":"2006","journal":"Nature","firstPage":"315","lastPage":"321","volume":"441"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000502303.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000502303.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC092807","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A6Q8PGQ1","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0A6Q8PGQ1","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000675083.1","properties":[{"key":"ProteinId","value":"ENSP00000502303.1"},{"key":"GeneId","value":"ENSG00000142871.19"}]},{"database":"HGNC","id":"HGNC:2654","properties":[{"key":"GeneName","value":"CCN1"}]},{"database":"GeneTree","id":"ENSGT00940000155151","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"365605at2759","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"Bgee","id":"ENSG00000142871","properties":[{"key":"ExpressionPatterns","value":"Expressed in left uterine tube and 206 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"A0A6Q8PGQ1","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]}],"sequence":{"value":"GLRQAAQRGLQQNAALRPHQGAGMQLRRQLHRSEGDLQSQRADPVNITPESTKTGKVSSPTVNISAHVLMAPWAAFLCVPKNYLSPTWAVPTLGWSKLPGSAARSGSVTRIVSRTPWRTRTASLARSWDSMPPRWS","length":136,"molWeight":14906,"crc64":"862C503AD3A10134","md5":"263D576457F9C68F69B4B652BCB64F70"},"extraAttributes":{"countByFeatureType":{"Region":1,"Compositional bias":1,"Non-terminal residue":1},"uniParcId":"UPI00162F8719"}}]}