{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P13500","secondaryAccessions":["B2R4V3","Q9UDF3"],"uniProtkbId":"CCL2_HUMAN","entryAudit":{"firstPublicDate":"1990-01-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1990-01-01","entryVersion":263,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"C-C motif chemokine 2"}},"alternativeNames":[{"fullName":{"value":"HC11"}},{"fullName":{"value":"Monocyte chemoattractant protein 1"}},{"fullName":{"value":"Monocyte chemotactic and activating factor"},"shortNames":[{"value":"MCAF"}]},{"fullName":{"value":"Monocyte chemotactic protein 1"},"shortNames":[{"value":"MCP-1"}]},{"fullName":{"value":"Monocyte secretory protein JE"}},{"fullName":{"value":"Small-inducible cytokine A2"}}],"flag":"Precursor"},"genes":[{"geneName":{"value":"CCL2"},"synonyms":[{"value":"MCP1"},{"value":"SCYA2"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10529171"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10587439"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8107690"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8195247"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8627182"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9792674"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9837883"}],"value":"Acts as a ligand for C-C chemokine receptor CCR2 (PubMed:10529171, PubMed:10587439, PubMed:9837883). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (PubMed:10587439, PubMed:9837883). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (PubMed:8195247, PubMed:8627182, PubMed:9792674). May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis (PubMed:8107690)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15033992"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27044744"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8898111"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8989326"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9792674"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9837883"}],"value":"Monomer or homodimer; in equilibrium (PubMed:15033992, PubMed:8898111, PubMed:8989326, PubMed:9837883). Is tethered on endothelial cells by glycosaminoglycan (GAG) side chains of proteoglycans (PubMed:9792674). Interacts with TNFAIP6 (via Link domain)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P13500","intActId":"EBI-1034732"},"interactantTwo":{"uniProtKBAccession":"P13501","geneName":"CCL5","intActId":"EBI-2848366"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P13500","intActId":"EBI-1034732"},"interactantTwo":{"uniProtKBAccession":"P80075","geneName":"CCL8","intActId":"EBI-16803830"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P13500","intActId":"EBI-1034732"},"interactantTwo":{"uniProtKBAccession":"P02776","geneName":"PF4","intActId":"EBI-2565740"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P13500","intActId":"EBI-1034732"},"interactantTwo":{"uniProtKBAccession":"P78317","geneName":"RNF4","intActId":"EBI-2340927"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P13500","intActId":"EBI-1034732"},"interactantTwo":{"uniProtKBAccession":"Q9Y320","geneName":"TMX2","intActId":"EBI-6447886"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P13500","intActId":"EBI-1034732"},"interactantTwo":{"uniProtKBAccession":"Q2F862","intActId":"EBI-16161937"},"numberOfExperiments":5,"organismDiffer":true},{"interactantOne":{"chainId":"PRO_0000005146","intActId":"EBI-11711396"},"interactantTwo":{"uniProtKBAccession":"P98066","geneName":"TNFAIP6","intActId":"EBI-11700693"},"numberOfExperiments":2,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23955712"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2513477"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23765988"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2513477"}],"value":"Expressed in the seminal plasma, endometrial fluid and follicular fluid (at protein level) (PubMed:23765988). Expressed in monocytes (PubMed:2513477)"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23233732"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23955712"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30568593"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34831181"}],"value":"Up-regulated upon hypertonic conditions (PubMed:23233732). In pancreatic islets, secretion is stimulated by IL1B (PubMed:23955712). Up-regulated by coagulation factor Xa (F10) in PAR-1 (F2R)-dependent manner in cardiac fibroblasts and endothelial cells (PubMed:30568593, PubMed:34831181). Up-regulated by thrombin (F2) in endothelial cells (PubMed:30568593)"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8627182"}],"value":"Processing at the N-terminus can regulate receptor and target cell selectivity (PubMed:8627182). Deletion of the N-terminal residue converts it from an activator of basophil to an eosinophil chemoattractant (PubMed:8627182)"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2513477"}],"value":"N-Glycosylated"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16352737"}],"value":"Genetic variations in CCL2 determine Mycobacterium tuberculosis susceptibility [MIM:607948]"}],"commentType":"POLYMORPHISM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the intercrine beta (chemokine CC) family"}],"commentType":"SIMILARITY"},{"commentType":"WEB RESOURCE","resourceName":"Wikipedia","resourceUrl":"https://en.wikipedia.org/wiki/CCL2","ftp":false,"note":"CCL2 entry"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":23,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2648385"}]},{"type":"Chain","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":99,"modifier":"EXACT"}},"description":"C-C motif chemokine 2","featureId":"PRO_0000005146"},{"type":"Site","location":{"start":{"value":31,"modifier":"EXACT"},"end":{"value":31,"modifier":"EXACT"}},"description":"Involved in dimerization"},{"type":"Site","location":{"start":{"value":36,"modifier":"EXACT"},"end":{"value":36,"modifier":"EXACT"}},"description":"Involved in dimerization, receptor binding and signaling"},{"type":"Site","location":{"start":{"value":41,"modifier":"EXACT"},"end":{"value":41,"modifier":"EXACT"}},"description":"Involved in GAG binding"},{"type":"Site","location":{"start":{"value":42,"modifier":"EXACT"},"end":{"value":42,"modifier":"EXACT"}},"description":"Involved in GAG binding"},{"type":"Site","location":{"start":{"value":47,"modifier":"EXACT"},"end":{"value":47,"modifier":"EXACT"}},"description":"Involved in GAG binding and receptor binding"},{"type":"Site","location":{"start":{"value":58,"modifier":"EXACT"},"end":{"value":58,"modifier":"EXACT"}},"description":"Involved in dimerization"},{"type":"Site","location":{"start":{"value":61,"modifier":"EXACT"},"end":{"value":61,"modifier":"EXACT"}},"description":"Involved in dimerization"},{"type":"Site","location":{"start":{"value":72,"modifier":"EXACT"},"end":{"value":72,"modifier":"EXACT"}},"description":"Involved in GAG binding and receptor binding"},{"type":"Site","location":{"start":{"value":81,"modifier":"EXACT"},"end":{"value":81,"modifier":"EXACT"}},"description":"Involved in GAG binding"},{"type":"Site","location":{"start":{"value":89,"modifier":"EXACT"},"end":{"value":89,"modifier":"EXACT"}},"description":"Involved in GAG binding"},{"type":"Modified residue","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":24,"modifier":"EXACT"}},"description":"Pyrrolidone carboxylic acid","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1661560"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2648385"}]},{"type":"Glycosylation","location":{"start":{"value":37,"modifier":"EXACT"},"end":{"value":37,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Disulfide bond","location":{"start":{"value":34,"modifier":"EXACT"},"end":{"value":59,"modifier":"EXACT"}},"description":""},{"type":"Disulfide bond","location":{"start":{"value":35,"modifier":"EXACT"},"end":{"value":75,"modifier":"EXACT"}},"description":""},{"type":"Mutagenesis","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":91,"modifier":"EXACT"}},"description":"83% reduction in activity.","alternativeSequence":{}},{"type":"Mutagenesis","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":85,"modifier":"EXACT"}},"description":"90% reduction in activity.","alternativeSequence":{}},{"type":"Mutagenesis","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":24,"modifier":"EXACT"}},"description":"Loss of activity.","alternativeSequence":{}},{"type":"Mutagenesis","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":31,"modifier":"EXACT"}},"description":"Loss of signaling.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10587439"}],"alternativeSequence":{}},{"type":"Mutagenesis","location":{"start":{"value":26,"modifier":"EXACT"},"end":{"value":26,"modifier":"EXACT"}},"description":"Reduction in activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10587439"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":28,"modifier":"EXACT"}},"description":"Slight reduction in activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10587439"}],"alternativeSequence":{"originalSequence":"I","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":29,"modifier":"EXACT"},"end":{"value":29,"modifier":"EXACT"}},"description":"50% reduction in activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10587439"}],"alternativeSequence":{"originalSequence":"N","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":31,"modifier":"EXACT"},"end":{"value":31,"modifier":"EXACT"}},"description":"Loss of dimerization; slight reduction of activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10587439"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9837883"}],"alternativeSequence":{"originalSequence":"P","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":32,"modifier":"EXACT"},"end":{"value":32,"modifier":"EXACT"}},"description":"Slight reduction in activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10587439"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9837883"}],"alternativeSequence":{"originalSequence":"V","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":32,"modifier":"EXACT"},"end":{"value":32,"modifier":"EXACT"}},"description":"Slight reduction in affinity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10587439"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9837883"}],"alternativeSequence":{"originalSequence":"V","alternativeSequences":["E"]}},{"type":"Mutagenesis","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":33,"modifier":"EXACT"}},"description":"Slight reduction in activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10587439"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9837883"}],"alternativeSequence":{"originalSequence":"T","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":33,"modifier":"EXACT"}},"description":"Slight reduction in affinity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10587439"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9837883"}],"alternativeSequence":{"originalSequence":"T","alternativeSequences":["E"]}},{"type":"Mutagenesis","location":{"start":{"value":36,"modifier":"EXACT"},"end":{"value":36,"modifier":"EXACT"}},"description":"Loss of activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9837883"}],"alternativeSequence":{"originalSequence":"Y","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":41,"modifier":"EXACT"},"end":{"value":42,"modifier":"EXACT"}},"description":"Abolishes binding to Link domain of TNFAIP6.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27044744"}],"alternativeSequence":{"originalSequence":"RK","alternativeSequences":["AA"]}},{"type":"Mutagenesis","location":{"start":{"value":47,"modifier":"EXACT"},"end":{"value":47,"modifier":"EXACT"}},"description":"95% reduction in activity; strong reduction of receptor binding.","alternativeSequence":{"originalSequence":"R","alternativeSequences":["F"]}},{"type":"Mutagenesis","location":{"start":{"value":50,"modifier":"EXACT"},"end":{"value":50,"modifier":"EXACT"}},"description":"40% reduction in activity.","alternativeSequence":{"originalSequence":"S","alternativeSequences":["Q"]}},{"type":"Mutagenesis","location":{"start":{"value":51,"modifier":"EXACT"},"end":{"value":51,"modifier":"EXACT"}},"description":"Loss of activity.","alternativeSequence":{"originalSequence":"Y","alternativeSequences":["D"]}},{"type":"Mutagenesis","location":{"start":{"value":53,"modifier":"EXACT"},"end":{"value":53,"modifier":"EXACT"}},"description":"Loss of activity.","alternativeSequence":{"originalSequence":"R","alternativeSequences":["L"]}},{"type":"Mutagenesis","location":{"start":{"value":79,"modifier":"EXACT"},"end":{"value":79,"modifier":"EXACT"}},"description":"No effect on heparin binding.","alternativeSequence":{"originalSequence":"K","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":81,"modifier":"EXACT"},"end":{"value":81,"modifier":"EXACT"}},"description":"Strongly reduces heparin binding.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9792674"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":89,"modifier":"EXACT"},"end":{"value":89,"modifier":"EXACT"}},"description":"Strongly reduces heparin binding.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9792674"}],"alternativeSequence":{"originalSequence":"H","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":91,"modifier":"EXACT"},"end":{"value":91,"modifier":"EXACT"}},"description":"90% reduction in activity.","alternativeSequence":{"originalSequence":"D","alternativeSequences":["L"]}},{"type":"Mutagenesis","location":{"start":{"value":95,"modifier":"EXACT"},"end":{"value":99,"modifier":"EXACT"}},"description":"No effect on heparin binding.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9792674"}],"alternativeSequence":{}},{"type":"Helix","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":29,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1DOK"}]},{"type":"Beta strand","location":{"start":{"value":32,"modifier":"EXACT"},"end":{"value":34,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1DOK"}]},{"type":"Helix","location":{"start":{"value":42,"modifier":"EXACT"},"end":{"value":44,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7SO0"}]},{"type":"Helix","location":{"start":{"value":45,"modifier":"EXACT"},"end":{"value":47,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7SO0"}]},{"type":"Beta strand","location":{"start":{"value":48,"modifier":"EXACT"},"end":{"value":54,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7SO0"}]},{"type":"Beta strand","location":{"start":{"value":59,"modifier":"EXACT"},"end":{"value":61,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7SO0"}]},{"type":"Beta strand","location":{"start":{"value":63,"modifier":"EXACT"},"end":{"value":68,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7SO0"}]},{"type":"Beta strand","location":{"start":{"value":73,"modifier":"EXACT"},"end":{"value":76,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7SO0"}]},{"type":"Beta strand","location":{"start":{"value":78,"modifier":"EXACT"},"end":{"value":80,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4ZK9"}]},{"type":"Helix","location":{"start":{"value":81,"modifier":"EXACT"},"end":{"value":95,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7SO0"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0145","category":"Biological process","name":"Chemotaxis"},{"id":"KW-0202","category":"Molecular function","name":"Cytokine"},{"id":"KW-0903","category":"Technical term","name":"Direct protein sequencing"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-0395","category":"Biological process","name":"Inflammatory response"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-0873","category":"PTM","name":"Pyrrolidone carboxylic acid"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"2923622","citationType":"journal article","authors":["Furutani Y.","Nomura H.","Notake M.","Oyamada Y.","Fukui T.","Yamada M.","Larsen C.G.","Oppenheim J.J.","Matsushima K."],"citationCrossReferences":[{"database":"PubMed","id":"2923622"},{"database":"DOI","id":"10.1016/0006-291x(89)92430-3"}],"title":"Cloning and sequencing of the cDNA for human monocyte chemotactic and activating factor (MCAF).","publicationDate":"1989","journal":"Biochem. Biophys. Res. Commun.","firstPage":"249","lastPage":"255","volume":"159"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"]},{"referenceNumber":2,"citation":{"id":"2513477","citationType":"journal article","authors":["Rollins B.J.","Stier P.","Ernst T.","Wong G.G."],"citationCrossReferences":[{"database":"PubMed","id":"2513477"},{"database":"DOI","id":"10.1128/mcb.9.11.4687-4695.1989"}],"title":"The human homolog of the JE gene encodes a monocyte secretory protein.","publicationDate":"1989","journal":"Mol. Cell. Biol.","firstPage":"4687","lastPage":"4695","volume":"9"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]","SUBCELLULAR LOCATION","GLYCOSYLATION","TISSUE SPECIFICITY"]},{"referenceNumber":3,"citation":{"id":"2465924","citationType":"journal article","authors":["Yoshimura T.","Yuhki N.","Moore S.K.","Appella E.","Lerman M.I.","Leonard E.J."],"citationCrossReferences":[{"database":"PubMed","id":"2465924"},{"database":"DOI","id":"10.1016/0014-5793(89)80590-3"}],"title":"Human monocyte chemoattractant protein-1 (MCP-1). Full-length cDNA cloning, expression in mitogen-stimulated blood mononuclear leukocytes, and sequence similarity to mouse competence gene JE.","publicationDate":"1989","journal":"FEBS Lett.","firstPage":"487","lastPage":"493","volume":"244"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"],"referenceComments":[{"value":"Glial tumor","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"2518726","citationType":"journal article","authors":["Chang H.C.","Hsu F.","Freeman G.J.","Griffin J.D.","Reinherz E.L."],"citationCrossReferences":[{"database":"PubMed","id":"2518726"},{"database":"DOI","id":"10.1093/intimm/1.4.388"}],"title":"Cloning and expression of a gamma-interferon-inducible gene in monocytes: a new member of a cytokine gene family.","publicationDate":"1989","journal":"Int. Immunol.","firstPage":"388","lastPage":"397","volume":"1"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"]},{"referenceNumber":5,"citation":{"id":"2357211","citationType":"journal article","authors":["Shyy Y.J.","Li Y.S.","Kolattukudy P.E."],"citationCrossReferences":[{"database":"PubMed","id":"2357211"},{"database":"DOI","id":"10.1016/0006-291x(90)90338-n"}],"title":"Structure of human monocyte chemotactic protein gene and its regulation by TPA.","publicationDate":"1990","journal":"Biochem. Biophys. Res. Commun.","firstPage":"346","lastPage":"351","volume":"169"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":6,"citation":{"id":"1661560","citationType":"journal article","authors":["Yoshimura T.","Leonard E.J."],"citationCrossReferences":[{"database":"PubMed","id":"1661560"},{"database":"DOI","id":"10.1007/978-1-4684-6009-4_6"}],"title":"Human monocyte chemoattractant protein-1 (MCP-1).","publicationDate":"1991","journal":"Adv. Exp. Med. Biol.","firstPage":"47","lastPage":"56","volume":"305"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"]},{"referenceNumber":7,"citation":{"id":"8107690","citationType":"journal article","authors":["Li Y.S.","Shyy Y.J.","Wright J.G.","Valente A.J.","Cornhill J.F.","Kolattukudy P.E."],"citationCrossReferences":[{"database":"PubMed","id":"8107690"},{"database":"DOI","id":"10.1007/bf01772208"}],"title":"The expression of monocyte chemotactic protein (MCP-1) in human vascular endothelium in vitro and in vivo.","publicationDate":"1993","journal":"Mol. Cell. Biochem.","firstPage":"61","lastPage":"68","volume":"126"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]","FUNCTION"]},{"referenceNumber":8,"citation":{"id":"10918580","citationType":"journal article","authors":["Finzer P.","Soto U.","Delius H.","Patzelt A.","Poustka A.","Coy J.F.","zur Hausen H.","Roesl F."],"citationCrossReferences":[{"database":"PubMed","id":"10918580"},{"database":"DOI","id":"10.1038/sj.onc.1203643"}],"title":"Differential transcriptional regulation of the monocyte-chemoattractant protein-1 (MCP-1) gene in tumorigenic and non-tumorigenic HPV 18 positive cells: the role of the chromatin structure and AP-1 composition.","publicationDate":"2000","journal":"Oncogene","firstPage":"3235","lastPage":"3244","volume":"19"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":9,"citation":{"id":"CI-E825DQFSBEGB","citationType":"patent","authors":["Caput D.","Ferrara P.","Miloux B.","Minty A.","Vita N."],"title":"Protein with cytokine activity, recombinant DNA, expression vector and hosts for obtaining it.","publicationDate":"03-JUN-1992","patentNumber":"EP0488900"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"]},{"referenceNumber":10,"citation":{"id":"CI-4IUTJLP3044AK","citationType":"submission","authors":["Kalnine N.","Chen X.","Rolfs A.","Halleck A.","Hines L.","Eisenstein S.","Koundinya M.","Raphael J.","Moreira D.","Kelley T.","LaBaer J.","Lin Y.","Phelan M.","Farmer A."],"title":"Cloning of human full-length CDSs in BD Creator(TM) system donor vector.","publicationDate":"MAY-2003","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"]},{"referenceNumber":11,"citation":{"id":"CI-C6517G2GQQCG3","citationType":"submission","authoringGroup":["SeattleSNPs variation discovery resource"],"publicationDate":"JUN-2002","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":12,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Urinary bladder","type":"TISSUE"}]},{"referenceNumber":13,"citation":{"id":"CI-5GBD0VIIJ7C63","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"SEP-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":14,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Pancreas","type":"TISSUE"}]},{"referenceNumber":15,"citation":{"id":"2648385","citationType":"journal article","authors":["Robinson E.A.","Yoshimura T.","Leonard E.J.","Tanaka S.","Griffin P.R.","Shabanowitz J.","Hunt D.F.","Appella E."],"citationCrossReferences":[{"database":"PubMed","id":"2648385"},{"database":"DOI","id":"10.1073/pnas.86.6.1850"}],"title":"Complete amino acid sequence of a human monocyte chemoattractant, a putative mediator of cellular immune reactions.","publicationDate":"1989","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"1850","lastPage":"1854","volume":"86"},"referencePositions":["PROTEIN SEQUENCE OF 24-99","PYROGLUTAMATE FORMATION AT GLN-24"]},{"referenceNumber":16,"citation":{"id":"2322286","citationType":"journal article","authors":["Decock B.","Conings R.","Lenaerts J.-P.","Biliau A.","van Damme J."],"citationCrossReferences":[{"database":"PubMed","id":"2322286"},{"database":"DOI","id":"10.1016/0006-291x(90)90609-q"}],"title":"Identification of the monocyte chemotactic protein from human osteosarcoma cells and monocytes: detection of a novel N-terminally processed form.","publicationDate":"1990","journal":"Biochem. Biophys. Res. Commun.","firstPage":"904","lastPage":"909","volume":"167"},"referencePositions":["PROTEIN SEQUENCE OF 29-53 AND 82-92"]},{"referenceNumber":17,"citation":{"id":"2071154","citationType":"journal article","authors":["Rollins B.J.","Morton C.C.","Ledbetter D.H.","Eddy R.L. Jr.","Shows T.B."],"citationCrossReferences":[{"database":"PubMed","id":"2071154"},{"database":"DOI","id":"10.1016/0888-7543(91)90338-f"}],"title":"Assignment of the human small inducible cytokine A2 gene, SCYA2 (encoding JE or MCP-1), to 17q11.2-12: evolutionary relatedness of cytokines clustered at the same locus.","publicationDate":"1991","journal":"Genomics","firstPage":"489","lastPage":"492","volume":"10"},"referencePositions":["GENE STRUCTURE"]},{"referenceNumber":18,"citation":{"id":"8195247","citationType":"journal article","authors":["Zhang Y.J.","Rutledge B.J.","Rollins B.J."],"citationCrossReferences":[{"database":"PubMed","id":"8195247"},{"database":"DOI","id":"10.1016/s0021-9258(17)40768-x"}],"title":"Structure/activity analysis of human monocyte chemoattractant protein-1 (MCP-1) by mutagenesis. Identification of a mutated protein that inhibits MCP-1-mediated monocyte chemotaxis.","publicationDate":"1994","journal":"J. Biol. Chem.","firstPage":"15918","lastPage":"15924","volume":"269"},"referencePositions":["FUNCTION","MUTAGENESIS"]},{"referenceNumber":19,"citation":{"id":"8627182","citationType":"journal article","authors":["Weber M.","Uguccioni M.","Baggiolini M.","Clark-Lewis I.","Dahinden C.A."],"citationCrossReferences":[{"database":"PubMed","id":"8627182"},{"database":"DOI","id":"10.1084/jem.183.2.681"}],"title":"Deletion of the NH2-terminal residue converts monocyte chemotactic protein 1 from an activator of basophil mediator release to an eosinophil chemoattractant.","publicationDate":"1996","journal":"J. Exp. Med.","firstPage":"681","lastPage":"685","volume":"183"},"referencePositions":["FUNCTION","EFFECT OF DELETION OF N-TERMINAL RESIDUES"]},{"referenceNumber":20,"citation":{"id":"8898111","citationType":"journal article","authors":["Kim K.-S.","Rajarathnam K.","Clark-Lewis I.","Sykes B.D."],"citationCrossReferences":[{"database":"PubMed","id":"8898111"},{"database":"DOI","id":"10.1016/0014-5793(96)01024-1"}],"title":"Structural characterization of a monomeric chemokine: monocyte chemoattractant protein-3.","publicationDate":"1996","journal":"FEBS Lett.","firstPage":"277","lastPage":"282","volume":"395"},"referencePositions":["SUBUNIT"]},{"referenceNumber":21,"citation":{"id":"9792674","citationType":"journal article","authors":["Chakravarty L.","Rogers L.","Quach T.","Breckenridge S.","Kolattukudy P.E."],"citationCrossReferences":[{"database":"PubMed","id":"9792674"},{"database":"DOI","id":"10.1074/jbc.273.45.29641"}],"title":"Lysine 58 and histidine 66 at the C-terminal alpha-helix of monocyte chemoattractant protein-1 are essential for glycosaminoglycan binding.","publicationDate":"1998","journal":"J. Biol. Chem.","firstPage":"29641","lastPage":"29647","volume":"273"},"referencePositions":["FUNCTION","GAG BINDING SITES LYS-81 AND HIS-89","MUTAGENESIS OF LYS-81; HIS-89 AND 95-GLN--THR-99"]},{"referenceNumber":22,"citation":{"id":"9837883","citationType":"journal article","authors":["Paavola C.D.","Hemmerich S.","Grunberger D.","Polsky I.","Bloom A.","Freedman R.","Mulkins M.","Bhakta S.","McCarley D.","Wiesent L.","Wong B.","Jarnagin K.","Handel T.M."],"citationCrossReferences":[{"database":"PubMed","id":"9837883"},{"database":"DOI","id":"10.1074/jbc.273.50.33157"}],"title":"Monomeric monocyte chemoattractant protein-1 (MCP-1) binds and activates the MCP-1 receptor CCR2B.","publicationDate":"1998","journal":"J. Biol. Chem.","firstPage":"33157","lastPage":"33165","volume":"273"},"referencePositions":["FUNCTION","HOMODIMERIZATION","MUTAGENESIS OF PRO-31; VAL-32; THR-33 AND TYR-36"]},{"referenceNumber":23,"citation":{"id":"10587439","citationType":"journal article","authors":["Jarnagin K.","Grunberger D.","Mulkins M.","Wong B.","Hemmerich S.","Paavola C.","Bloom A.","Bhakta S.","Diehl F.","Freedman R.","McCarley D.","Polsky I.","Ping-Tsou A.","Kosaka A.","Handel T.M."],"citationCrossReferences":[{"database":"PubMed","id":"10587439"},{"database":"DOI","id":"10.1021/bi9912239"}],"title":"Identification of surface residues of the monocyte chemotactic protein 1 that affect signaling through the receptor CCR2.","publicationDate":"1999","journal":"Biochemistry","firstPage":"16167","lastPage":"16177","volume":"38"},"referencePositions":["FUNCTION","MUTAGENESIS OF 25-PRO--PRO-31; ASP-26; ILE-28; ASN-29; PRO-31; VAL-32 AND THR-33"]},{"referenceNumber":24,"citation":{"id":"10529171","citationType":"journal article","authors":["Hemmerich S.","Paavola C.","Bloom A.","Bhakta S.","Freedman R.","Grunberger D.","Krstenansky J.","Lee S.","McCarley D.","Mulkins M.","Wong B.","Pease J.","Mizoue L.","Mirzadegan T.","Polsky I.","Thompson K.","Handel T.M.","Jarnagin K."],"citationCrossReferences":[{"database":"PubMed","id":"10529171"},{"database":"DOI","id":"10.1021/bi991029m"}],"title":"Identification of residues in the monocyte chemotactic protein-1 that contact the MCP-1 receptor, CCR2.","publicationDate":"1999","journal":"Biochemistry","firstPage":"13013","lastPage":"13025","volume":"38"},"referencePositions":["FUNCTION","IMPORTANCE OF TYR-36; ARG-47; LYS-58; LYS-61 AND LYS-72 FOR RECEPTOR BINDING","MUTAGENESIS"]},{"referenceNumber":25,"citation":{"id":"15033992","citationType":"journal article","authors":["Lau E.K.","Paavola C.D.","Johnson Z.","Gaudry J.-P.","Geretti E.","Borlat F.","Kungl A.J.","Proudfoot A.E.","Handel T.M."],"citationCrossReferences":[{"database":"PubMed","id":"15033992"},{"database":"DOI","id":"10.1074/jbc.m311224200"}],"title":"Identification of the glycosaminoglycan binding site of the CC chemokine, MCP-1: implications for structure and function in vivo.","publicationDate":"2004","journal":"J. Biol. Chem.","firstPage":"22294","lastPage":"22305","volume":"279"},"referencePositions":["GAG BINDING SITES ARG-41; LYS-42 AND ARG-47","MUTAGENESIS","SUBUNIT"]},{"referenceNumber":26,"citation":{"id":"23233732","citationType":"journal article","authors":["Ueno M.","Shen W.J.","Patel S.","Greenberg A.S.","Azhar S.","Kraemer F.B."],"citationCrossReferences":[{"database":"PubMed","id":"23233732"},{"database":"DOI","id":"10.1194/jlr.m033365"}],"title":"Fat-specific protein 27 modulates nuclear factor of activated T cells 5 and the cellular response to stress.","publicationDate":"2013","journal":"J. Lipid Res.","firstPage":"734","lastPage":"743","volume":"54"},"referencePositions":["INDUCTION BY OSMOTIC STRESS"]},{"referenceNumber":27,"citation":{"id":"23955712","citationType":"journal article","authors":["Jourdan T.","Godlewski G.","Cinar R.","Bertola A.","Szanda G.","Liu J.","Tam J.","Han T.","Mukhopadhyay B.","Skarulis M.C.","Ju C.","Aouadi M.","Czech M.P.","Kunos G."],"citationCrossReferences":[{"database":"PubMed","id":"23955712"},{"database":"DOI","id":"10.1038/nm.3265"}],"title":"Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes.","publicationDate":"2013","journal":"Nat. Med.","firstPage":"1132","lastPage":"1140","volume":"19"},"referencePositions":["SUBCELLULAR LOCATION","INDUCTION BY IL1B"]},{"referenceNumber":28,"citation":{"id":"23765988","citationType":"journal article","authors":["Caballero-Campo P.","Buffone M.G.","Benencia F.","Conejo-Garcia J.R.","Rinaudo P.F.","Gerton G.L."],"citationCrossReferences":[{"database":"PubMed","id":"23765988"},{"database":"DOI","id":"10.1002/jcp.24418"}],"title":"A role for the chemokine receptor CCR6 in mammalian sperm motility and chemotaxis.","publicationDate":"2014","journal":"J. Cell. Physiol.","firstPage":"68","lastPage":"78","volume":"229"},"referencePositions":["TISSUE SPECIFICITY"]},{"referenceNumber":29,"citation":{"id":"30568593","citationType":"journal article","authors":["Shinozawa E.","Nakayama M.","Imura Y."],"citationCrossReferences":[{"database":"PubMed","id":"30568593"},{"database":"DOI","id":"10.3389/fphar.2018.01431"}],"title":"TAK-442, a Direct Factor Xa Inhibitor, Inhibits Monocyte Chemoattractant Protein 1 Production in Endothelial Cells via Involvement of Protease-Activated Receptor 1.","publicationDate":"2018","journal":"Front. Pharmacol.","firstPage":"1431","lastPage":"1431","volume":"9"},"referencePositions":["INDUCTION BY F10 AND F2"]},{"referenceNumber":30,"citation":{"id":"34831181","citationType":"journal article","authors":["D'Alessandro E.","Scaf B.","Munts C.","van Hunnik A.","Trevelyan C.J.","Verheule S.","Spronk H.M.H.","Turner N.A.","Ten Cate H.","Schotten U.","van Nieuwenhoven F.A."],"citationCrossReferences":[{"database":"PubMed","id":"34831181"},{"database":"DOI","id":"10.3390/cells10112958"}],"title":"Coagulation Factor Xa Induces Proinflammatory Responses in Cardiac Fibroblasts via Activation of Protease-Activated Receptor-1.","publicationDate":"2021","journal":"Cells","firstPage":"0","lastPage":"0","volume":"10"},"referencePositions":["INDUCTION BY F10"]},{"referenceNumber":31,"citation":{"id":"1857712","citationType":"journal article","authors":["Gronenborn A.M.","Clore G.M."],"citationCrossReferences":[{"database":"PubMed","id":"1857712"},{"database":"DOI","id":"10.1093/protein/4.3.263"}],"title":"Modeling the three-dimensional structure of the monocyte chemo-attractant and activating protein MCAF/MCP-1 on the basis of the solution structure of interleukin-8.","publicationDate":"1991","journal":"Protein Eng.","firstPage":"263","lastPage":"269","volume":"4"},"referencePositions":["3D-STRUCTURE MODELING"]},{"referenceNumber":32,"citation":{"id":"8639605","citationType":"journal article","authors":["Handel T.M.","Domaille P.J."],"citationCrossReferences":[{"database":"PubMed","id":"8639605"},{"database":"DOI","id":"10.1021/bi9602270"}],"title":"Heteronuclear (1H, 13C, 15N) NMR assignments and solution structure of the monocyte chemoattractant protein-1 (MCP-1) dimer.","publicationDate":"1996","journal":"Biochemistry","firstPage":"6569","lastPage":"6584","volume":"35"},"referencePositions":["STRUCTURE BY NMR"]},{"referenceNumber":33,"citation":{"id":"8989326","citationType":"journal article","authors":["Lubkowski J.","Bujacz G.","Domaille P.J.","Handel T.M.","Wlodawer A."],"citationCrossReferences":[{"database":"PubMed","id":"8989326"},{"database":"DOI","id":"10.1038/nsb0197-64"}],"title":"The structure of MCP-1 in two crystal forms provides a rare example of variable quaternary interactions.","publicationDate":"1997","journal":"Nat. Struct. Biol.","firstPage":"64","lastPage":"69","volume":"4"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS)","SUBUNIT"]},{"referenceNumber":34,"citation":{"id":"16352737","citationType":"journal article","authors":["Flores-Villanueva P.O.","Ruiz-Morales J.A.","Song C.-H.","Flores L.M.","Jo E.-K.","Montano M.","Barnes P.F.","Selman M.","Granados J."],"citationCrossReferences":[{"database":"PubMed","id":"16352737"},{"database":"DOI","id":"10.1084/jem.20050126"}],"title":"A functional promoter polymorphism in monocyte chemoattractant protein-1 is associated with increased susceptibility to pulmonary tuberculosis.","publicationDate":"2005","journal":"J. Exp. Med.","firstPage":"1649","lastPage":"1658","volume":"202"},"referencePositions":["INVOLVEMENT IN MYCOBACTERIUM TUBERCULOSIS SUSCEPTIBILITY"]},{"referenceNumber":35,"citation":{"id":"27044744","citationType":"journal article","authors":["Dyer D.P.","Salanga C.L.","Johns S.C.","Valdambrini E.","Fuster M.M.","Milner C.M.","Day A.J.","Handel T.M."],"citationCrossReferences":[{"database":"PubMed","id":"27044744"},{"database":"DOI","id":"10.1074/jbc.m116.720953"}],"title":"The Anti-inflammatory Protein TSG-6 Regulates Chemokine Function by Inhibiting Chemokine/Glycosaminoglycan Interactions.","publicationDate":"2016","journal":"J. Biol. Chem.","firstPage":"12627","lastPage":"12640","volume":"291"},"referencePositions":["INTERACTION WITH TNFAIP6","MUTAGENESIS OF 41-ARG-LYS-42"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"M24545","properties":[{"key":"ProteinId","value":"AAA18164.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"M28225","properties":[{"key":"ProteinId","value":"AAA60308.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M28223","properties":[{"key":"ProteinId","value":"AAA60308.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M28224","properties":[{"key":"ProteinId","value":"AAA60308.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M28226","properties":[{"key":"ProteinId","value":"AAA60309.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"M31626","properties":[{"key":"ProteinId","value":"AAA36330.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M30816","properties":[{"key":"ProteinId","value":"AAA36330.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M31625","properties":[{"key":"ProteinId","value":"AAA36330.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"X14768","properties":[{"key":"ProteinId","value":"CAA32876.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"M37719","properties":[{"key":"ProteinId","value":"AAA18102.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"S71513","properties":[{"key":"ProteinId","value":"AAB20651.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"S69738","properties":[{"key":"ProteinId","value":"AAB29926.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"Y18933","properties":[{"key":"ProteinId","value":"CAC14049.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"A17786","properties":[{"key":"ProteinId","value":"CAA01352.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BT007329","properties":[{"key":"ProteinId","value":"AAP35993.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF519531","properties":[{"key":"ProteinId","value":"AAM54046.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AK311960","properties":[{"key":"ProteinId","value":"BAG34900.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"CH471147","properties":[{"key":"ProteinId","value":"EAW80212.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC009716","properties":[{"key":"ProteinId","value":"AAH09716.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS11277.1","properties":[{"key":"Description","value":"-"}]},{"database":"PIR","id":"A35474","properties":[{"key":"EntryName","value":"A60299"}]},{"database":"RefSeq","id":"NP_002973.1","properties":[{"key":"NucleotideSequenceId","value":"NM_002982.4"}]},{"database":"PDB","id":"1DOK","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.85 A"},{"key":"Chains","value":"A/B=24-99"}]},{"database":"PDB","id":"1DOL","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.40 A"},{"key":"Chains","value":"A=24-99"}]},{"database":"PDB","id":"1DOM","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A/B=24-99"}]},{"database":"PDB","id":"1DON","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A/B=24-99"}]},{"database":"PDB","id":"1ML0","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.80 A"},{"key":"Chains","value":"D=24-99"}]},{"database":"PDB","id":"2BDN","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.53 A"},{"key":"Chains","value":"A=24-99"}]},{"database":"PDB","id":"2NZ1","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"D/E/Y=24-99"}]},{"database":"PDB","id":"3IFD","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A=24-99"}]},{"database":"PDB","id":"4DN4","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.80 A"},{"key":"Chains","value":"M=24-99"}]},{"database":"PDB","id":"4R8I","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.05 A"},{"key":"Chains","value":"A=24-99"}]},{"database":"PDB","id":"4ZK9","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.60 A"},{"key":"Chains","value":"B=24-99"}]},{"database":"PDB","id":"7SO0","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.74 A"},{"key":"Chains","value":"B=24-99"}]},{"database":"PDB","id":"7XA3","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.90 A"},{"key":"Chains","value":"L=24-92"}]},{"database":"PDB","id":"8FJ0","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.91 A"},{"key":"Chains","value":"D/E/F=24-99"}]},{"database":"PDBsum","id":"1DOK","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1DOL","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1DOM","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1DON","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1ML0","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2BDN","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2NZ1","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3IFD","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4DN4","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4R8I","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4ZK9","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7SO0","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7XA3","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8FJ0","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"P13500","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-33086","properties":[{"key":"Description","value":"-"}]},{"database":"MDposit","id":"P13500","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P13500","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"112251","properties":[{"key":"Interactions","value":"32"}]},{"database":"DIP","id":"DIP-5838N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P13500","properties":[{"key":"Number of interactors","value":"1005"}]},{"database":"IntAct","id":"P13500","properties":[{"key":"Interactions","value":"20"}]},{"database":"MINT","id":"P13500","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-CCL2","properties":[{"key":"Evidences","value":"44 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000225831","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"P13500","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL1649052","properties":[{"key":"Description","value":"-"}]},{"database":"DrugBank","id":"DB12739","properties":[{"key":"GenericName","value":"Bindarit"}]},{"database":"DrugBank","id":"DB09301","properties":[{"key":"GenericName","value":"Chondroitin sulfate"}]},{"database":"DrugBank","id":"DB01406","properties":[{"key":"GenericName","value":"Danazol"}]},{"database":"DrugBank","id":"DB01055","properties":[{"key":"GenericName","value":"Mimosine"}]},{"database":"DrugCentral","id":"P13500","properties":[{"key":"Description","value":"-"}]},{"database":"GlyCosmos","id":"P13500","properties":[{"key":"glycosylation","value":"1 site, No reported glycans"}]},{"database":"GlyGen","id":"P13500","properties":[{"key":"glycosylation","value":"1 site"}]},{"database":"PhosphoSitePlus","id":"P13500","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"CCL2","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"126842","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"P13500","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000225831","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P13500","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"52921","properties":[{"key":"Description","value":"-"}]},{"database":"ABCD","id":"P13500","properties":[{"key":"antibodies","value":"30 sequenced antibodies"}]},{"database":"Antibodypedia","id":"4427","properties":[{"key":"antibodies","value":"1805 antibodies from 50 providers"}]},{"database":"DNASU","id":"6347","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000225831.4","properties":[{"key":"ProteinId","value":"ENSP00000225831.4"},{"key":"GeneId","value":"ENSG00000108691.10"}]},{"database":"GeneID","id":"6347","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:6347","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000225831.4","properties":[{"key":"ProteinId","value":"ENSP00000225831.4"},{"key":"RefSeqNucleotideId","value":"NM_002982.4"},{"key":"RefSeqProteinId","value":"NP_002973.1"}]},{"database":"UCSC","id":"uc002hhy.4","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:10618","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA130413151","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"6347","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"6347","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"CCL2","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:10618","properties":[{"key":"GeneName","value":"CCL2"}]},{"database":"HPA","id":"ENSG00000108691","properties":[{"key":"ExpressionPatterns","value":"Tissue enhanced (urinary)"}]},{"database":"MalaCards","id":"CCL2","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"158105","properties":[{"key":"Type","value":"gene"}]},{"database":"MIM","id":"607948","properties":[{"key":"Type","value":"phenotype"}]},{"database":"OpenTargets","id":"ENSG00000108691","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000108691","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502S6ZP","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT01130000278316","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_141716_1_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P13500","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"PNQKWVK","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"8934837at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"P13500","properties":[{"key":"Number of GO annotations","value":"8 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"P13500","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"P13500","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-380108","properties":[{"key":"PathwayName","value":"Chemokine receptors bind chemokines"}]},{"database":"Reactome","id":"R-HSA-380994","properties":[{"key":"PathwayName","value":"ATF4 activates genes in response to endoplasmic reticulum stress"}]},{"database":"Reactome","id":"R-HSA-6783783","properties":[{"key":"PathwayName","value":"Interleukin-10 signaling"}]},{"database":"Reactome","id":"R-HSA-6785807","properties":[{"key":"PathwayName","value":"Interleukin-4 and Interleukin-13 signaling"}]},{"database":"Reactome","id":"R-HSA-9818026","properties":[{"key":"PathwayName","value":"NFE2L2 regulating inflammation associated genes"}]},{"database":"SignaLink","id":"P13500","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"P13500","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000108691","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"6347","properties":[{"key":"hits","value":"13 hits in 1162 CRISPR screens"}]},{"database":"ChiTaRS","id":"CCL2","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"P13500","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"CCL2","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"6347","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"P13500","properties":[{"key":"DevelopmentLevel","value":"Tchem"}]},{"database":"PRO","id":"PR:P13500","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 17"}]},{"database":"RNAct","id":"P13500","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000108691","properties":[{"key":"ExpressionPatterns","value":"Expressed in vena cava and 175 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"P13500","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20041150"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"25411203"}]},{"database":"GO","id":"GO:0048020","properties":[{"key":"GoTerm","value":"F:CCR chemokine receptor binding"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0031727","properties":[{"key":"GoTerm","value":"F:CCR2 chemokine receptor binding"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0042056","properties":[{"key":"GoTerm","value":"F:chemoattractant activity"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"25411203"}]},{"database":"GO","id":"GO:0008009","properties":[{"key":"GoTerm","value":"F:chemokine activity"},{"key":"GoEvidenceType","value":"IDA:UniProt"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"9792674"}]},{"database":"GO","id":"GO:0042379","properties":[{"key":"GoTerm","value":"F:chemokine receptor binding"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"25411203"}]},{"database":"GO","id":"GO:0004672","properties":[{"key":"GoTerm","value":"F:protein kinase activity"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"9973507"}]},{"database":"GO","id":"GO:0005102","properties":[{"key":"GoTerm","value":"F:signaling receptor binding"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"10542238"}]},{"database":"GO","id":"GO:0001525","properties":[{"key":"GoTerm","value":"P:angiogenesis"},{"key":"GoEvidenceType","value":"TAS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"18334747"}]},{"database":"GO","id":"GO:0009887","properties":[{"key":"GoTerm","value":"P:animal organ morphogenesis"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"9364936"}]},{"database":"GO","id":"GO:0061844","properties":[{"key":"GoTerm","value":"P:antimicrobial humoral immune response mediated by antimicrobial peptide"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0043615","properties":[{"key":"GoTerm","value":"P:astrocyte cell migration"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12271471"}]},{"database":"GO","id":"GO:0007155","properties":[{"key":"GoTerm","value":"P:cell adhesion"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"10198043"}]},{"database":"GO","id":"GO:0007166","properties":[{"key":"GoTerm","value":"P:cell surface receptor signaling pathway"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"9548499"}]},{"database":"GO","id":"GO:0007259","properties":[{"key":"GoTerm","value":"P:cell surface receptor signaling pathway via JAK-STAT"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"9670957"}]},{"database":"GO","id":"GO:0019725","properties":[{"key":"GoTerm","value":"P:cellular homeostasis"},{"key":"GoEvidenceType","value":"TAS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"18334747"}]},{"database":"GO","id":"GO:0044344","properties":[{"key":"GoTerm","value":"P:cellular response to fibroblast growth factor stimulus"},{"key":"GoEvidenceType","value":"IEP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000270","source":"PubMed","id":"9407497"}]},{"database":"GO","id":"GO:0071347","properties":[{"key":"GoTerm","value":"P:cellular response to interleukin-1"},{"key":"GoEvidenceType","value":"IEP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000270","source":"PubMed","id":"9407497"}]},{"database":"GO","id":"GO:0071222","properties":[{"key":"GoTerm","value":"P:cellular response to lipopolysaccharide"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0071356","properties":[{"key":"GoTerm","value":"P:cellular response to tumor necrosis factor"},{"key":"GoEvidenceType","value":"IEP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000270","source":"PubMed","id":"9407497"}]},{"database":"GO","id":"GO:0071346","properties":[{"key":"GoTerm","value":"P:cellular response to type II interferon"},{"key":"GoEvidenceType","value":"IEP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000270","source":"PubMed","id":"9407497"}]},{"database":"GO","id":"GO:0038148","properties":[{"key":"GoTerm","value":"P:chemokine (C-C motif) ligand 2 signaling pathway"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0070098","properties":[{"key":"GoTerm","value":"P:chemokine-mediated signaling pathway"},{"key":"GoEvidenceType","value":"IDA:UniProt"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"9792674"}]},{"database":"GO","id":"GO:0006935","properties":[{"key":"GoTerm","value":"P:chemotaxis"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"10623817"}]},{"database":"GO","id":"GO:0019221","properties":[{"key":"GoTerm","value":"P:cytokine-mediated signaling pathway"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12207323"}]},{"database":"GO","id":"GO:0007010","properties":[{"key":"GoTerm","value":"P:cytoskeleton organization"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10072545"}]},{"database":"GO","id":"GO:0048245","properties":[{"key":"GoTerm","value":"P:eosinophil chemotaxis"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0007186","properties":[{"key":"GoTerm","value":"P:G protein-coupled receptor signaling pathway"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"10542238"}]},{"database":"GO","id":"GO:0007187","properties":[{"key":"GoTerm","value":"P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"10770925"}]},{"database":"GO","id":"GO:0035684","properties":[{"key":"GoTerm","value":"P:helper T cell extravasation"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0006959","properties":[{"key":"GoTerm","value":"P:humoral immune response"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"9548499"}]},{"database":"GO","id":"GO:0006954","properties":[{"key":"GoTerm","value":"P:inflammatory response"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0048246","properties":[{"key":"GoTerm","value":"P:macrophage chemotaxis"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12207323"}]},{"database":"GO","id":"GO:0002548","properties":[{"key":"GoTerm","value":"P:monocyte chemotaxis"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12207323"}]},{"database":"GO","id":"GO:2000134","properties":[{"key":"GoTerm","value":"P:negative regulation of G1/S transition of mitotic cell cycle"},{"key":"GoEvidenceType","value":"IMP:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"25466836"}]},{"database":"GO","id":"GO:0034351","properties":[{"key":"GoTerm","value":"P:negative regulation of glial cell apoptotic process"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12753088"}]},{"database":"GO","id":"GO:2000502","properties":[{"key":"GoTerm","value":"P:negative regulation of natural killer cell chemotaxis"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"7545673"}]},{"database":"GO","id":"GO:0043524","properties":[{"key":"GoTerm","value":"P:negative regulation of neuron apoptotic process"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12753088"}]},{"database":"GO","id":"GO:1905563","properties":[{"key":"GoTerm","value":"P:negative regulation of vascular endothelial cell proliferation"},{"key":"GoEvidenceType","value":"IMP:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"25466836"}]},{"database":"GO","id":"GO:2000427","properties":[{"key":"GoTerm","value":"P:positive regulation of apoptotic cell clearance"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0090280","properties":[{"key":"GoTerm","value":"P:positive regulation of calcium ion import"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10925302"}]},{"database":"GO","id":"GO:0030335","properties":[{"key":"GoTerm","value":"P:positive regulation of cell migration"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0007204","properties":[{"key":"GoTerm","value":"P:positive regulation of cytosolic calcium ion concentration"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"25411203"}]},{"database":"GO","id":"GO:2000353","properties":[{"key":"GoTerm","value":"P:positive regulation of endothelial cell apoptotic process"},{"key":"GoEvidenceType","value":"IMP:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"25466836"}]},{"database":"GO","id":"GO:0010628","properties":[{"key":"GoTerm","value":"P:positive regulation of gene expression"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:1900451","properties":[{"key":"GoTerm","value":"P:positive regulation of glutamate receptor signaling pathway"},{"key":"GoEvidenceType","value":"ISS:ARUK-UCL"}]},{"database":"GO","id":"GO:0010759","properties":[{"key":"GoTerm","value":"P:positive regulation of macrophage chemotaxis"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0051968","properties":[{"key":"GoTerm","value":"P:positive regulation of synaptic transmission, glutamatergic"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0050870","properties":[{"key":"GoTerm","value":"P:positive regulation of T cell activation"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0006468","properties":[{"key":"GoTerm","value":"P:protein phosphorylation"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"9670957"}]},{"database":"GO","id":"GO:0008360","properties":[{"key":"GoTerm","value":"P:regulation of cell shape"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10072545"}]},{"database":"GO","id":"GO:0009617","properties":[{"key":"GoTerm","value":"P:response to bacterium"},{"key":"GoEvidenceType","value":"NAS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16034137"}]},{"database":"GO","id":"GO:0019233","properties":[{"key":"GoTerm","value":"P:sensory perception of pain"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0007165","properties":[{"key":"GoTerm","value":"P:signal transduction"},{"key":"GoEvidenceType","value":"NAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"10770925"}]},{"database":"GO","id":"GO:0019079","properties":[{"key":"GoTerm","value":"P:viral genome replication"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"10985244"}]},{"database":"CDD","id":"cd00272","properties":[{"key":"EntryName","value":"Chemokine_CC"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.40.50.40:FF:000002","properties":[{"key":"EntryName","value":"C-C motif chemokine"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.40.50.40","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR039809","properties":[{"key":"EntryName","value":"Chemokine_b/g/d"}]},{"database":"InterPro","id":"IPR000827","properties":[{"key":"EntryName","value":"Chemokine_CC_CS"}]},{"database":"InterPro","id":"IPR001811","properties":[{"key":"EntryName","value":"Chemokine_IL8-like_dom"}]},{"database":"InterPro","id":"IPR036048","properties":[{"key":"EntryName","value":"Interleukin_8-like_sf"}]},{"database":"PANTHER","id":"PTHR12015:SF98","properties":[{"key":"EntryName","value":"C-C MOTIF CHEMOKINE 2"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR12015","properties":[{"key":"EntryName","value":"SMALL INDUCIBLE CYTOKINE A"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00048","properties":[{"key":"EntryName","value":"IL8"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00199","properties":[{"key":"EntryName","value":"SCY"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54117","properties":[{"key":"EntryName","value":"Interleukin 8-like chemokines"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00472","properties":[{"key":"EntryName","value":"SMALL_CYTOKINES_CC"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MKVSAALLCLLLIAATFIPQGLAQPDAINAPVTCCYNFTNRKISVQRLASYRRITSSKCPKEAVIFKTIVAKEICADPKQKWVQDSMDHLDKQTQTPKT","length":99,"molWeight":11025,"crc64":"45EC72361435302F","md5":"69ECCA20CDB224403221D4CDD35BE9B6"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"INTERACTION":7,"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1,"INDUCTION":1,"PTM":2,"POLYMORPHISM":1,"SIMILARITY":1,"WEB RESOURCE":1},"countByFeatureType":{"Signal":1,"Chain":1,"Site":10,"Modified residue":1,"Glycosylation":1,"Disulfide bond":2,"Mutagenesis":23,"Helix":4,"Beta strand":6},"uniParcId":"UPI0000000DC9"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"J3KRT7","uniProtkbId":"J3KRT7_HUMAN","entryAudit":{"firstPublicDate":"2012-10-03","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2012-10-03","entryVersion":84,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000462156.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000462156.1"}],"value":"C-C motif chemokine ligand 2"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000462156.1"}],"value":"CCL2"}}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":23,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":65,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5014098596"},{"type":"Domain","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":64,"modifier":"EXACT"}},"description":"Chemokine interleukin-8-like","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00048"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022514"}],"id":"KW-0202","category":"Molecular function","name":"Cytokine"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"J3KRT7"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000462156.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000462156.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16625196","citationType":"journal article","authors":["Zody M.C.","Garber M.","Adams D.J.","Sharpe T.","Harrow J.","Lupski J.R.","Nicholson C.","Searle S.M.","Wilming L.","Young S.K.","Abouelleil A.","Allen N.R.","Bi W.","Bloom T.","Borowsky M.L.","Bugalter B.E.","Butler J.","Chang J.L.","Chen C.K.","Cook A.","Corum B.","Cuomo C.A.","de Jong P.J.","DeCaprio D.","Dewar K.","FitzGerald M.","Gilbert J.","Gibson R.","Gnerre S.","Goldstein S.","Grafham D.V.","Grocock R.","Hafez N.","Hagopian D.S.","Hart E.","Norman C.H.","Humphray S.","Jaffe D.B.","Jones M.","Kamal M.","Khodiyar V.K.","LaButti K.","Laird G.","Lehoczky J.","Liu X.","Lokyitsang T.","Loveland J.","Lui A.","Macdonald P.","Major J.E.","Matthews L.","Mauceli E.","McCarroll S.A.","Mihalev A.H.","Mudge J.","Nguyen C.","Nicol R.","O'Leary S.B.","Osoegawa K.","Schwartz D.C.","Shaw-Smith C.","Stankiewicz P.","Steward C.","Swarbreck D.","Venkataraman V.","Whittaker C.A.","Yang X.","Zimmer A.R.","Bradley A.","Hubbard T.","Birren B.W.","Rogers J.","Lander E.S.","Nusbaum C."],"citationCrossReferences":[{"database":"PubMed","id":"16625196"},{"database":"DOI","id":"10.1038/nature04689"}],"title":"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.","publicationDate":"2006","journal":"Nature","firstPage":"1045","lastPage":"1049","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000462156.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000462156.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC005549","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"J3KRT7","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"J3KRT7","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"4427","properties":[{"key":"antibodies","value":"1805 antibodies from 50 providers"}]},{"database":"Ensembl","id":"ENST00000580907.6","properties":[{"key":"ProteinId","value":"ENSP00000462156.1"},{"key":"GeneId","value":"ENSG00000108691.10"}]},{"database":"UCSC","id":"uc060dyg.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:10618","properties":[{"key":"GeneName","value":"CCL2"}]},{"database":"OpenTargets","id":"ENSG00000108691","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000108691","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT01130000278316","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_141716_7_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"8934837at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"CCL2","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 17"}]},{"database":"Bgee","id":"ENSG00000108691","properties":[{"key":"ExpressionPatterns","value":"Expressed in vena cava and 175 other cell types or tissues"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0008009","properties":[{"key":"GoTerm","value":"F:chemokine activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006955","properties":[{"key":"GoTerm","value":"P:immune response"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"2.40.50.40","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001811","properties":[{"key":"EntryName","value":"Chemokine_IL8-like_dom"}]},{"database":"InterPro","id":"IPR036048","properties":[{"key":"EntryName","value":"Interleukin_8-like_sf"}]},{"database":"Pfam","id":"PF00048","properties":[{"key":"EntryName","value":"IL8"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54117","properties":[{"key":"EntryName","value":"Interleukin 8-like chemokines"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MKVSAALLCLLLIAATFIPQGLAQPDAINAPVTCCYNFTNRKISVQRLASYRRITSSKCPKEAVM","length":65,"molWeight":7101,"crc64":"940FD437909E16D6","md5":"A00A0183FDE327A53A97488A609993E4"},"extraAttributes":{"countByFeatureType":{"Signal":1,"Chain":1,"Domain":1},"uniParcId":"UPI0000E59F13"}}]}