{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q92583","secondaryAccessions":["A0N0Q9","Q2M287"],"uniProtkbId":"CCL17_HUMAN","entryAudit":{"firstPublicDate":"1998-07-15","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1997-02-01","entryVersion":200,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"C-C motif chemokine 17"}},"alternativeNames":[{"fullName":{"value":"CC chemokine TARC"}},{"fullName":{"value":"Small-inducible cytokine A17"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"8702936"}],"value":"Thymus and activation-regulated chemokine"}}],"flag":"Precursor"},"genes":[{"geneName":{"value":"CCL17"},"synonyms":[{"value":"SCYA17"},{"value":"TARC"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9WUZ6"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10540332"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27525438"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8702936"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9169480"}],"value":"Chemokine, which displays chemotactic activity for T lymphocytes, preferentially Th2 cells, but not monocytes or granulocytes. Therefore plays an important role in a wide range of inflammatory and immunological processes (PubMed:8702936, PubMed:9169480). Acts by binding to CCR4 at T-cell surface (PubMed:10540332, PubMed:9169480). Mediates GM-CSF/CSF2-driven pain and inflammation (PubMed:27525438). In the brain, required to maintain the typical, highly branched morphology of hippocampal microglia under homeostatic conditions. May be important for the appropriate adaptation of microglial morphology and synaptic plasticity to acute lipopolysaccharide (LPS)-induced neuroinflammation (By similarity). Plays a role in wound healing, mainly by inducing fibroblast migration into the wound (By similarity)"}],"commentType":"FUNCTION"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q92583","intActId":"EBI-16640146"},"interactantTwo":{"uniProtKBAccession":"O00585","geneName":"CCL21","intActId":"EBI-953695"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q92583","intActId":"EBI-16640146"},"interactantTwo":{"uniProtKBAccession":"O15444","geneName":"CCL25","intActId":"EBI-7783341"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q92583","intActId":"EBI-16640146"},"interactantTwo":{"uniProtKBAccession":"Q9Y258","geneName":"CCL26","intActId":"EBI-7783416"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q92583","intActId":"EBI-16640146"},"interactantTwo":{"uniProtKBAccession":"Q9NRJ3","geneName":"CCL28","intActId":"EBI-7783254"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q92583","intActId":"EBI-16640146"},"interactantTwo":{"uniProtKBAccession":"P13501","geneName":"CCL5","intActId":"EBI-2848366"},"numberOfExperiments":9,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q92583","intActId":"EBI-16640146"},"interactantTwo":{"uniProtKBAccession":"P13501","geneName":"CCL5","chainId":"PRO_0000005175","intActId":"EBI-11712923"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q92583","intActId":"EBI-16640146"},"interactantTwo":{"uniProtKBAccession":"P51679","geneName":"CCR4","intActId":"EBI-7847466"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q92583","intActId":"EBI-16640146"},"interactantTwo":{"uniProtKBAccession":"P51681","geneName":"CCR5","intActId":"EBI-489374"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q92583","intActId":"EBI-16640146"},"interactantTwo":{"uniProtKBAccession":"P02776","geneName":"PF4","intActId":"EBI-2565740"},"numberOfExperiments":2,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27525438"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29871928"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8702936"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8702936"}],"value":"Constitutively expressed in thymus. Detected at lower levels in the lung, colon and small intestine (PubMed:8702936). Expressed in stimulated peripheral blood mononuclear cells, but not in resting cells (PubMed:8702936)"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27525438"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29871928"}],"value":"In monocytes, up-regulated by IL4 and by GM-CSF/CSF2 in an IRF4-dependent manner (at protein level)"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the intercrine beta (chemokine CC) family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10540332"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9169480"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9521068"}],"value":"Although CCL17 was shown to bind to CCR8, additional studies demonstrated that CCR4, not CCR8, was the bona fide CCL17 receptor"}],"commentType":"CAUTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"9521068"}],"value":"Was originally thought to be a ligand for CCR8"}],"commentType":"CAUTION"},{"commentType":"WEB RESOURCE","resourceName":"Wikipedia","resourceUrl":"https://en.wikipedia.org/wiki/CCL17","ftp":false,"note":"CCL17 entry"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":23,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8702936"}]},{"type":"Chain","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":94,"modifier":"EXACT"}},"description":"C-C motif chemokine 17","featureId":"PRO_0000005211"},{"type":"Disulfide bond","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":57,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12832759"}]},{"type":"Disulfide bond","location":{"start":{"value":34,"modifier":"EXACT"},"end":{"value":73,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12832759"}]},{"type":"Natural variant","location":{"start":{"value":5,"modifier":"EXACT"},"end":{"value":5,"modifier":"EXACT"}},"description":"in dbSNP:rs34693308","featureCrossReferences":[{"database":"dbSNP","id":"rs34693308"}],"featureId":"VAR_048708","alternativeSequence":{"originalSequence":"K","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":67,"modifier":"EXACT"},"end":{"value":67,"modifier":"EXACT"}},"description":"in dbSNP:rs34379253","featureCrossReferences":[{"database":"dbSNP","id":"rs34379253"}],"featureId":"VAR_048709","alternativeSequence":{"originalSequence":"V","alternativeSequences":["M"]}},{"type":"Beta strand","location":{"start":{"value":27,"modifier":"EXACT"},"end":{"value":29,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1NR4"}]},{"type":"Beta strand","location":{"start":{"value":31,"modifier":"EXACT"},"end":{"value":33,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7S4N"}]},{"type":"Helix","location":{"start":{"value":41,"modifier":"EXACT"},"end":{"value":43,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7SCV"}]},{"type":"Helix","location":{"start":{"value":44,"modifier":"EXACT"},"end":{"value":46,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7S4N"}]},{"type":"Beta strand","location":{"start":{"value":47,"modifier":"EXACT"},"end":{"value":52,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7S4N"}]},{"type":"Beta strand","location":{"start":{"value":57,"modifier":"EXACT"},"end":{"value":59,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7S4N"}]},{"type":"Beta strand","location":{"start":{"value":62,"modifier":"EXACT"},"end":{"value":66,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7S4N"}]},{"type":"Beta strand","location":{"start":{"value":71,"modifier":"EXACT"},"end":{"value":74,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7S4N"}]},{"type":"Helix","location":{"start":{"value":79,"modifier":"EXACT"},"end":{"value":90,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7S4N"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0145","category":"Biological process","name":"Chemotaxis"},{"id":"KW-0202","category":"Molecular function","name":"Cytokine"},{"id":"KW-0903","category":"Technical term","name":"Direct protein sequencing"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0395","category":"Biological process","name":"Inflammatory response"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"8702936","citationType":"journal article","authors":["Imai T.","Yoshida T.","Baba M.","Nishimura M.","Kakizaki M.","Yoshie O."],"citationCrossReferences":[{"database":"PubMed","id":"8702936"},{"database":"DOI","id":"10.1074/jbc.271.35.21514"}],"title":"Molecular cloning of a novel T cell-directed CC chemokine expressed in thymus by signal sequence trap using Epstein-Barr virus vector.","publicationDate":"1996","journal":"J. Biol. Chem.","firstPage":"21514","lastPage":"21521","volume":"271"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]","PROTEIN SEQUENCE OF 24-32","FUNCTION","SUBCELLULAR LOCATION","TISSUE SPECIFICITY"],"referenceComments":[{"value":"Peripheral blood monocyte","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"CI-JGR3DF5COMGD","citationType":"submission","authors":["Livingston R.J.","Shaffer T.","McFarland I.","Nguyen C.P.","Stanaway I.B.","Rajkumar N.","Johnson E.J.","da Ponte S.H.","Willa H.","Ahearn M.O.","Bertucci C.","Acklestad J.","Carroll A.","Swanson J.","Gildersleeve H.I.","Nickerson D.A."],"publicationDate":"OCT-2006","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":3,"citation":{"id":"10493829","citationType":"journal article","authors":["Loftus B.J.","Kim U.-J.","Sneddon V.P.","Kalush F.","Brandon R.","Fuhrmann J.","Mason T.","Crosby M.L.","Barnstead M.","Cronin L.","Mays A.D.","Cao Y.","Xu R.X.","Kang H.-L.","Mitchell S.","Eichler E.E.","Harris P.C.","Venter J.C.","Adams M.D."],"citationCrossReferences":[{"database":"PubMed","id":"10493829"},{"database":"DOI","id":"10.1006/geno.1999.5927"}],"title":"Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.","publicationDate":"1999","journal":"Genomics","firstPage":"295","lastPage":"308","volume":"60"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":4,"citation":{"id":"CI-5GBDQ6B103N1E","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"JUL-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":5,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"]},{"referenceNumber":6,"citation":{"id":"9169480","citationType":"journal article","authors":["Imai T.","Baba M.","Nishimura M.","Kakizaki M.","Takagi S.","Yoshie O."],"citationCrossReferences":[{"database":"PubMed","id":"9169480"},{"database":"DOI","id":"10.1074/jbc.272.23.15036"}],"title":"The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4.","publicationDate":"1997","journal":"J. Biol. Chem.","firstPage":"15036","lastPage":"15042","volume":"272"},"referencePositions":["FUNCTION","CAUTION"]},{"referenceNumber":7,"citation":{"id":"9521068","citationType":"journal article","authors":["Bernardini G.","Hedrick J.","Sozzani S.","Luini W.","Spinetti G.","Weiss M.","Menon S.","Zlotnik A.","Mantovani A.","Santoni A.","Napolitano M."],"citationCrossReferences":[{"database":"PubMed","id":"9521068"},{"database":"DOI","id":"10.1002/(sici)1521-4141(199802)28:02<582::aid-immu582>3.0.co;2-a"}],"title":"Identification of the CC chemokines TARC and macrophage inflammatory protein-1 beta as novel functional ligands for the CCR8 receptor.","publicationDate":"1998","journal":"Eur. J. Immunol.","firstPage":"582","lastPage":"588","volume":"28"},"referencePositions":["CAUTION"]},{"referenceNumber":8,"citation":{"id":"10540332","citationType":"journal article","authors":["Garlisi C.G.","Xiao H.","Tian F.","Hedrick J.A.","Billah M.M.","Egan R.W.","Umland S.P."],"citationCrossReferences":[{"database":"PubMed","id":"10540332"},{"database":"DOI","id":"10.1002/(sici)1521-4141(199910)29:10<3210::aid-immu3210>3.0.co;2-w"}],"title":"The assignment of chemokine-chemokine receptor pairs: TARC and MIP-1 beta are not ligands for human CC-chemokine receptor 8.","publicationDate":"1999","journal":"Eur. J. Immunol.","firstPage":"3210","lastPage":"3215","volume":"29"},"referencePositions":["FUNCTION","CAUTION"]},{"referenceNumber":9,"citation":{"id":"27525438","citationType":"journal article","authors":["Achuthan A.","Cook A.D.","Lee M.C.","Saleh R.","Khiew H.W.","Chang M.W.","Louis C.","Fleetwood A.J.","Lacey D.C.","Christensen A.D.","Frye A.T.","Lam P.Y.","Kusano H.","Nomura K.","Steiner N.","Foerster I.","Nutt S.L.","Olshansky M.","Turner S.J.","Hamilton J.A."],"citationCrossReferences":[{"database":"PubMed","id":"27525438"},{"database":"DOI","id":"10.1172/jci87828"}],"title":"Granulocyte macrophage colony-stimulating factor induces CCL17 production via IRF4 to mediate inflammation.","publicationDate":"2016","journal":"J. Clin. Invest.","firstPage":"3453","lastPage":"3466","volume":"126"},"referencePositions":["SUBCELLULAR LOCATION","INDUCTION BY CSF2"]},{"referenceNumber":10,"citation":{"id":"29871928","citationType":"journal article","authors":["Hsu A.T.","Lupancu T.J.","Lee M.C.","Fleetwood A.J.","Cook A.D.","Hamilton J.A.","Achuthan A."],"citationCrossReferences":[{"database":"PubMed","id":"29871928"},{"database":"DOI","id":"10.1074/jbc.ra118.002416"}],"title":"Epigenetic and transcriptional regulation of IL4-induced CCL17 production in human monocytes and murine macrophages.","publicationDate":"2018","journal":"J. Biol. Chem.","firstPage":"11415","lastPage":"11423","volume":"293"},"referencePositions":["SUBCELLULAR LOCATION","INDUCTION BY IL4"]},{"referenceNumber":11,"citation":{"id":"12832759","citationType":"journal article","authors":["Asojo O.A.","Boulegue C.","Hoover D.M.","Lu W.","Lubkowski J."],"citationCrossReferences":[{"database":"PubMed","id":"12832759"},{"database":"DOI","id":"10.1107/s0907444903009454"}],"title":"Structures of thymus and activation-regulated chemokine (TARC).","publicationDate":"2003","journal":"Acta Crystallogr. D","firstPage":"1165","lastPage":"1173","volume":"59"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.18 ANGSTROMS) OF 24-94","DISULFIDE BONDS"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"D43767","properties":[{"key":"ProteinId","value":"BAA07824.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"EF064767","properties":[{"key":"ProteinId","value":"ABK41950.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC004382","properties":[{"key":"ProteinId","value":"AAC24308.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471092","properties":[{"key":"ProteinId","value":"EAW82921.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC069107","properties":[{"key":"ProteinId","value":"AAH69107.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC112066","properties":[{"key":"ProteinId","value":"AAI12067.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC112068","properties":[{"key":"ProteinId","value":"AAI12069.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS10780.1","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_002978.1","properties":[{"key":"NucleotideSequenceId","value":"NM_002987.3"}]},{"database":"RefSeq","id":"XP_047290404.1","properties":[{"key":"NucleotideSequenceId","value":"XM_047434448.1"}]},{"database":"PDB","id":"1NR2","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.18 A"},{"key":"Chains","value":"A/B=24-94"}]},{"database":"PDB","id":"1NR4","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.72 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H=24-94"}]},{"database":"PDB","id":"5WK3","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A/B/C/D=24-94"}]},{"database":"PDB","id":"7S4N","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.65 A"},{"key":"Chains","value":"B/D=24-94"}]},{"database":"PDB","id":"7SCV","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.01 A"},{"key":"Chains","value":"B=24-94"}]},{"database":"PDB","id":"8FJ2","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.07 A"},{"key":"Chains","value":"B=24-94"}]},{"database":"PDB","id":"8SKK","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.10 A"},{"key":"Chains","value":"B=24-94"}]},{"database":"PDBsum","id":"1NR2","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1NR4","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5WK3","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7S4N","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7SCV","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8FJ2","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8SKK","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"Q92583","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q92583","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"112264","properties":[{"key":"Interactions","value":"11"}]},{"database":"DIP","id":"DIP-5842N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q92583","properties":[{"key":"Number of interactors","value":"806"}]},{"database":"IntAct","id":"Q92583","properties":[{"key":"Interactions","value":"15"}]},{"database":"NDEx","id":"IQUERY-CP-CCL17","properties":[{"key":"Evidences","value":"6 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000219244","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL4295915","properties":[{"key":"Description","value":"-"}]},{"database":"iPTMnet","id":"Q92583","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q92583","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"CCL17","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"3024711","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q92583","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000219244","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q92583","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"75341","properties":[{"key":"Description","value":"-"}]},{"database":"ABCD","id":"Q92583","properties":[{"key":"antibodies","value":"1 sequenced antibody"}]},{"database":"Antibodypedia","id":"3752","properties":[{"key":"antibodies","value":"545 antibodies from 38 providers"}]},{"database":"DNASU","id":"6361","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000219244.9","properties":[{"key":"ProteinId","value":"ENSP00000219244.4"},{"key":"GeneId","value":"ENSG00000102970.11"}]},{"database":"Ensembl","id":"ENST00000616880.1","properties":[{"key":"ProteinId","value":"ENSP00000480147.1"},{"key":"GeneId","value":"ENSG00000102970.11"}]},{"database":"GeneID","id":"6361","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:6361","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000219244.9","properties":[{"key":"ProteinId","value":"ENSP00000219244.4"},{"key":"RefSeqNucleotideId","value":"NM_002987.3"},{"key":"RefSeqProteinId","value":"NP_002978.1"}]},{"database":"UCSC","id":"uc002elj.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:10615","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA35548","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"6361","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"6361","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"CCL17","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:10615","properties":[{"key":"GeneName","value":"CCL17"}]},{"database":"HPA","id":"ENSG00000102970","properties":[{"key":"ExpressionPatterns","value":"Tissue enriched (lymphoid)"}]},{"database":"MIM","id":"601520","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000102970","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000102970","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502SWZ0","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT01100000263482","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_141716_6_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q92583","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"CCLDYFK","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9447832at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q92583","properties":[{"key":"Number of GO annotations","value":"0 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q92583","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q92583","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-380108","properties":[{"key":"PathwayName","value":"Chemokine receptors bind chemokines"}]},{"database":"SignaLink","id":"Q92583","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000102970","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"6361","properties":[{"key":"hits","value":"10 hits in 1137 CRISPR screens"}]},{"database":"EvolutionaryTrace","id":"Q92583","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"CCL17","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"6361","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q92583","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:Q92583","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 16"}]},{"database":"RNAct","id":"Q92583","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000102970","properties":[{"key":"ExpressionPatterns","value":"Expressed in male germ line stem cell (sensu Vertebrata) in testis and 118 other cell types or tissues"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27525438"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29871928"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8702936"}]},{"database":"GO","id":"GO:0008009","properties":[{"key":"GoTerm","value":"F:chemokine activity"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"9743322"}]},{"database":"GO","id":"GO:0005102","properties":[{"key":"GoTerm","value":"F:signaling receptor binding"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"8702936"},{"evidenceCode":"ECO:0000304","source":"PubMed","id":"9743322"}]},{"database":"GO","id":"GO:0060326","properties":[{"key":"GoTerm","value":"P:cell chemotaxis"},{"key":"GoEvidenceType","value":"TAS:UniProt"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"9743322"}]},{"database":"GO","id":"GO:0007267","properties":[{"key":"GoTerm","value":"P:cell-cell signaling"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"8702936"}]},{"database":"GO","id":"GO:0006935","properties":[{"key":"GoTerm","value":"P:chemotaxis"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"9743322"}]},{"database":"GO","id":"GO:0006955","properties":[{"key":"GoTerm","value":"P:immune response"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd00272","properties":[{"key":"EntryName","value":"Chemokine_CC"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.40.50.40:FF:000012","properties":[{"key":"EntryName","value":"C-C motif chemokine"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.40.50.40","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR039809","properties":[{"key":"EntryName","value":"Chemokine_b/g/d"}]},{"database":"InterPro","id":"IPR000827","properties":[{"key":"EntryName","value":"Chemokine_CC_CS"}]},{"database":"InterPro","id":"IPR001811","properties":[{"key":"EntryName","value":"Chemokine_IL8-like_dom"}]},{"database":"InterPro","id":"IPR036048","properties":[{"key":"EntryName","value":"Interleukin_8-like_sf"}]},{"database":"PANTHER","id":"PTHR12015:SF111","properties":[{"key":"EntryName","value":"C-C MOTIF CHEMOKINE 17"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR12015","properties":[{"key":"EntryName","value":"SMALL INDUCIBLE CYTOKINE A"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00048","properties":[{"key":"EntryName","value":"IL8"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00199","properties":[{"key":"EntryName","value":"SCY"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54117","properties":[{"key":"EntryName","value":"Interleukin 8-like chemokines"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00472","properties":[{"key":"EntryName","value":"SMALL_CYTOKINES_CC"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAPLKMLALVTLLLGASLQHIHAARGTNVGRECCLEYFKGAIPLRKLKTWYQTSEDCSRDAIVFVTVQGRAICSDPNNKRVKNAVKYLQSLERS","length":94,"molWeight":10507,"crc64":"7959C56BA8FDAF08","md5":"325CC96D66E7530ADBDC93AE03122130"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"INTERACTION":9,"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1,"INDUCTION":1,"SIMILARITY":1,"CAUTION":2,"WEB RESOURCE":1},"countByFeatureType":{"Signal":1,"Chain":1,"Disulfide bond":2,"Natural variant":2,"Beta strand":6,"Helix":3},"uniParcId":"UPI00001362D9"}}]}