{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P49662","secondaryAccessions":["A2NHL8","A2NHL9","A2NHM0","B3KPZ9","B4DJH5","B4E2D2","O95601","Q7KYX7","Q9UG96"],"uniProtkbId":"CASP4_HUMAN","entryAudit":{"firstPublicDate":"1996-02-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1996-02-01","entryVersion":225,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15123740"}],"value":"Caspase-4"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15123740"}],"value":"CASP-4"}],"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23516580"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37993712"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37993714"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7797510"}],"value":"3.4.22.57"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"7797510"}],"value":"ICE and Ced-3 homolog 2"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"7797510"}],"value":"ICH-2"}]},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"7797592"}],"value":"ICE(rel)-II"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.4"}],"value":"Mih1"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"7743998"}],"value":"Protease TX"}}],"contains":[{"recommendedName":{"fullName":{"value":"Caspase-4 subunit p10"}}},{"recommendedName":{"fullName":{"value":"Caspase-4 subunit p20"}}}],"flag":"Precursor"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15123740"},{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:1505"}],"value":"CASP4"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"7797510"}],"value":"ICH2"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P70343"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15123740"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15326478"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22246630"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23516580"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23661706"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24879791"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25119034"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25121752"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25964352"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26173988"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26174085"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26375003"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26508369"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28314590"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29520027"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31268602"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32109412"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32510692"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32581219"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33377178"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34671164"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37001519"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37993714"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7743998"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7797510"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7797592"}],"value":"Inflammatory caspase that acts as the effector of the non-canonical inflammasome by mediating lipopolysaccharide (LPS)-induced pyroptosis (PubMed:25119034, PubMed:26375003, PubMed:32109412, PubMed:34671164, PubMed:37001519, PubMed:37993712, PubMed:37993714). Also indirectly activates the NLRP3 and NLRP6 inflammasomes (PubMed:23516580, PubMed:26375003, PubMed:32109412, PubMed:7797510). Acts as a thiol protease that cleaves a tetrapeptide after an Asp residue at position P1: catalyzes cleavage of CGAS, GSDMD and IL18 (PubMed:15326478, PubMed:23516580, PubMed:26375003, PubMed:28314590, PubMed:32109412, PubMed:37993712, PubMed:37993714, PubMed:7797510). Effector of the non-canonical inflammasome independently of NLRP3 inflammasome and CASP1: the non-canonical inflammasome promotes pyroptosis through GSDMD cleavage without involving secretion of cytokine IL1B (PubMed:25119034, PubMed:25121752, PubMed:26375003, PubMed:31268602, PubMed:32109412, PubMed:37993712, PubMed:37993714). In the non-canonical inflammasome, CASP4 is activated by direct binding to the lipid A moiety of LPS without the need of an upstream sensor (PubMed:25119034, PubMed:25121752, PubMed:29520027, PubMed:32510692, PubMed:32581219, PubMed:37993712). LPS-binding promotes CASP4 activation and CASP4-mediated cleavage of GSDMD and IL18, followed by IL18 secretion through the GSDMD pore, pyroptosis of infected cells and their extrusion into the gut lumen (PubMed:25119034, PubMed:25121752, PubMed:37993712, PubMed:37993714). Also indirectly promotes secretion of mature cytokines (IL1A and HMGB1) downstream of GSDMD-mediated pyroptosis via activation of the NLRP3 and NLRP6 inflammasomes (PubMed:26375003, PubMed:32109412). Involved in NLRP3-dependent CASP1 activation and IL1B secretion in response to non-canonical activators, such as UVB radiation or cholera enterotoxin (PubMed:22246630, PubMed:23516580, PubMed:24879791, PubMed:25964352, PubMed:26173988, PubMed:26174085, PubMed:26508369). Involved in NLRP6 inflammasome-dependent activation in response to lipoteichoic acid (LTA), a cell-wall component of Gram-positive bacteria, which leads to CASP1 activation and IL1B secretion (PubMed:33377178). Involved in LPS-induced IL6 secretion; this activity may not require caspase enzymatic activity (PubMed:26508369). The non-canonical inflammasome is required for innate immunity to cytosolic, but not vacuolar, bacteria (By similarity). Plays a crucial role in the restriction of S.typhimurium replication in colonic epithelial cells during infection (PubMed:25121752, PubMed:25964352). Activation of the non-canonical inflammasome in brain endothelial cells can lead to excessive pyroptosis, leading to blood-brain barrier breakdown (By similarity). Pyroptosis limits bacterial replication, while cytokine secretion promotes the recruitment and activation of immune cells and triggers mucosal inflammation (PubMed:25121752, PubMed:25964352, PubMed:26375003). May also act as an activator of adaptive immunity in dendritic cells, following activation by oxidized phospholipid 1-palmitoyl-2-arachidonoyl- sn-glycero-3-phosphorylcholine, an oxidized phospholipid (oxPAPC) (By similarity). Involved in cell death induced by endoplasmic reticulum stress and by treatment with cytotoxic APP peptides found in Alzheimer's patient brains (PubMed:15123740, PubMed:22246630, PubMed:23661706). Cleavage of GSDMD is not strictly dependent on the consensus cleavage site but depends on an exosite interface on CASP4 that recognizes and binds the Gasdermin-D, C-terminal (GSDMD-CT) part (PubMed:32109412). Catalyzes cleavage and maturation of IL18; IL18 processing also depends of the exosite interface on CASP4 (PubMed:15326478, PubMed:37993712, PubMed:37993714). In contrast, it does not directly process IL1B (PubMed:7743998, PubMed:7797510, PubMed:7797592). During non-canonical inflammasome activation, cuts CGAS and may play a role in the regulation of antiviral innate immune activation (PubMed:28314590)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29077095"}],"value":"(Microbial infection) In response to the Td92 surface protein of the periodontal pathogen T.denticola, activated by cathepsin CTSG which leads to production and secretion of IL1A and pyroptosis of gingival fibroblasts"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"Strict requirement for Asp at the P1 position. It has a preferred cleavage sequence of Tyr-Val-Ala-Asp-|- but also cleaves at Asp-Glu-Val-Asp-|-.","ecNumber":"3.4.22.57","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23516580"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37993712"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37993714"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7797510"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P70343"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25119034"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29520027"}],"value":"Activated by homooligomerization induced by direct binding to cytosolic LPS, in a TLR4-independent manner (PubMed:25119034, PubMed:29520027). In addition to LPS, CASP4/CASP11 may also be activated by oxidized phospholipid 1-palmitoyl-2-arachidonoyl- sn-glycero-3-phosphorylcholine, an oxidized phospholipid (oxPAPC), in dendritic cells, promoting adaptive immunity (By similarity). The role of oxPAPC is however unclear and another report suggests that oxPAPC competes with LPS-binding and inhibits the non-canonical inflammasome in macrophages (PubMed:29520027)"}],"commentType":"ACTIVITY REGULATION"},{"commentType":"BIOPHYSICOCHEMICAL PROPERTIES","kineticParameters":{"michaelisConstants":[{"constant":681.0,"unit":"uM","substrate":"synthetic peptide acetyl-YVAD-p-nitroanilide","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7797510"}]}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7797510"}],"value":"Values obtained using the partial C-terminal enzyme sequence of 105-377."}]}}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P70343"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18511561"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22246630"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23661706"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25119034"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30692621"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32109412"}],"value":"Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (Caspase-4 subunit p20) and a 10 kDa (Caspase-4 subunit p10) subunit (PubMed:32109412). Upon direct LPS-binding, forms large homooligomers, resulting in its activation (By similarity). These oligomers are often referred to as 'non-canonical inflammasomes' (PubMed:25119034). In its precursor form, interacts with TMEM214; this interaction is required for association with the endoplasmic reticulum membrane (PubMed:23661706). Interacts with CASP1 (PubMed:22246630). Interacts with NOD2 (PubMed:18511561). Interacts with SERPINB1; this interaction regulates CASP4 activity (PubMed:30692621)"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32109412"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37993714"}],"value":"Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (Caspase-4 subunit p20) and a 10 kDa (Caspase-4 subunit p10) subunit"}],"commentType":"SUBUNIT","molecule":"Caspase-4 subunit p20"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32109412"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37993714"}],"value":"Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (Caspase-4 subunit p20) and a 10 kDa (Caspase-4 subunit p10) subunit"}],"commentType":"SUBUNIT","molecule":"Caspase-4 subunit p10"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23516580"}],"value":"(Microbial infection) Interacts with NleF protein from pathogenic E.coli; this interaction leads to enzyme inhibition"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29077095"}],"value":"(Microbial infection) Interacts with cathepsin CTSG; the interaction is promoted by the Td92 surface protein of the periodontal pathogen T.denticola and leads to CASP4 activation"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P49662","intActId":"EBI-1057327"},"interactantTwo":{"uniProtKBAccession":"Q17R89","geneName":"ARHGAP44","intActId":"EBI-720416"},"numberOfExperiments":2,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15123740"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22246630"}],"value":"Predominantly localizes to the endoplasmic reticulum (ER). Association with the ER membrane requires TMEM214 (PubMed:15123740). Released in the extracellular milieu by keratinocytes following UVB irradiation (PubMed:22246630)"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23661706"}],"value":"Cytoplasm, cytosol","id":"SL-0091"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15123740"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23661706"}],"value":"Endoplasmic reticulum membrane","id":"SL-0097"},"topology":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23661706"}],"value":"Peripheral membrane protein","id":"SL-9903"},"orientation":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23661706"}],"value":"Cytoplasmic side","id":"SL-9910"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15123740"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23661706"}],"value":"Mitochondrion","id":"SL-0173"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25119034"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26508369"}],"value":"Inflammasome","id":"SL-0488"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22246630"}],"value":"Secreted","id":"SL-0243"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"synonyms":[{"value":"Alpha"}],"isoformIds":["P49662-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"synonyms":[{"value":"Gamma"},{"value":"mih1-beta"}],"isoformIds":["P49662-2"],"sequenceIds":["VSP_043495"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"synonyms":[{"value":"mih1-delta"}],"isoformIds":["P49662-3"],"sequenceIds":["VSP_058177","VSP_058178"],"isoformSequenceStatus":"Described"},{"name":{"value":"4"},"isoformIds":["P49662-4"],"sequenceIds":["VSP_058181","VSP_058182"],"isoformSequenceStatus":"Described"},{"name":{"value":"5"},"isoformIds":["P49662-5"],"sequenceIds":["VSP_058179","VSP_058180"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10986288"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22246630"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25121752"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7743998"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7797510"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7797592"}],"value":"Widely expressed, including in keratinocytes and colonic and small intestinal epithelial cells (at protein level). Not detected in brain"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16893518"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24879791"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25695505"}],"value":"In peripheral blood mononuclear cells and purified monocytes, up-regulated by bacterial lipopolysaccharides (LPS) and interferon-beta/IFNB1 at the mRNA level (PubMed:16893518, PubMed:24879791). However, this increase is not observed at the protein level, which remains constant in monocytes and other cell types following LPS treatment (PubMed:25121752, PubMed:26508369). In monocyte-derived macrophages, some up-regulation at the protein level is observed following treatment with LPS and IFNB1 (PubMed:25964352). In SH-EP1 neuroblastoma cell line, up-regulated by NF-kappa-B RELA/p65 at both mRNA and protein levels"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25119034"}],"value":"The CARD domain mediates LPS recognition and homooligomerization"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15123740"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32109412"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34671164"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37993714"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7743998"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7797510"}],"value":"In response to activation signals, undergoes autoproteolytic cleavage and activation"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34671164"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35338844"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36624349"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37014865"}],"value":"(Microbial infection) ADP-riboxanation by S.flexneri OspC3 blocks CASP4 autoprocessing, preventing CASP4 activation and ability to recognize and cleave GSDMD, thereby thwarting the inflammasome/pyroptosis-mediated defense"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"May be due to competing acceptor splice site. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay"}],"commentType":"MISCELLANEOUS","molecule":"Isoform 3"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the peptidase C14A family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous translation","sequence":"AAC99854.1","note":"Erroneous CDS prediction.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous gene model prediction","sequence":"EAW67050.1","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","molecule":"Isoform 2","sequenceCautionType":"Frameshift","sequence":"AAC99851.1","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Propeptide","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":80,"modifier":"UNSURE"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":"PRO_0000004596"},{"type":"Chain","location":{"start":{"value":81,"modifier":"UNSURE"},"end":{"value":270,"modifier":"EXACT"}},"description":"Caspase-4 subunit p20","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"32109412"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"37993714"}],"featureId":"PRO_0000004597"},{"type":"Propeptide","location":{"start":{"value":271,"modifier":"EXACT"},"end":{"value":289,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"7797510"}],"featureId":"PRO_0000004598"},{"type":"Chain","location":{"start":{"value":290,"modifier":"EXACT"},"end":{"value":377,"modifier":"EXACT"}},"description":"Caspase-4 subunit p10","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"32109412"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"37993714"}],"featureId":"PRO_0000004599"},{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":91,"modifier":"EXACT"}},"description":"CARD","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00046"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":59,"modifier":"EXACT"}},"description":"Required for LPS-binding","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P70343"}]},{"type":"Region","location":{"start":{"value":84,"modifier":"EXACT"},"end":{"value":104,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Active site","location":{"start":{"value":210,"modifier":"EXACT"},"end":{"value":210,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P29466"}]},{"type":"Active site","location":{"start":{"value":258,"modifier":"EXACT"},"end":{"value":258,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22246630"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23661706"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25119034"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37993712"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37993714"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7743998"}]},{"type":"Site","location":{"start":{"value":289,"modifier":"EXACT"},"end":{"value":290,"modifier":"EXACT"}},"description":"Cleavage; by autolysis","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37993714"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7797510"}]},{"type":"Modified residue","location":{"start":{"value":83,"modifier":"EXACT"},"end":{"value":83,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"}]},{"type":"Modified residue","location":{"start":{"value":314,"modifier":"EXACT"},"end":{"value":314,"modifier":"EXACT"}},"description":"(Microbial infection) ADP-riboxanated arginine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34671164"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35338844"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36624349"}]},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":56,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.4"}],"featureId":"VSP_043495","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":88,"modifier":"EXACT"},"end":{"value":116,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.4"}],"featureId":"VSP_058177","alternativeSequence":{"originalSequence":"AHPNMEAGPPESGESTDALKLCPHEEFLR","alternativeSequences":["GDKLGHRGRNHNLCSAISCSSSEYGGWTT"]}},{"type":"Alternative sequence","location":{"start":{"value":117,"modifier":"EXACT"},"end":{"value":377,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.4"}],"featureId":"VSP_058178","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":125,"modifier":"EXACT"},"end":{"value":157,"modifier":"EXACT"}},"description":"in isoform 5","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"}],"featureId":"VSP_058179","alternativeSequence":{"originalSequence":"IYPIKERNNRTRLALIICNTEFDHLPPRNGADF","alternativeSequences":["VLCYLYEIEKKEEISLLSFSAPFLTALNDWGWG"]}},{"type":"Alternative sequence","location":{"start":{"value":158,"modifier":"EXACT"},"end":{"value":377,"modifier":"EXACT"}},"description":"in isoform 5","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"}],"featureId":"VSP_058180","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":261,"modifier":"EXACT"},"end":{"value":263,"modifier":"EXACT"}},"description":"in isoform 4","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11230166"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"}],"featureId":"VSP_058181","alternativeSequence":{"originalSequence":"ANR","alternativeSequences":["GEC"]}},{"type":"Alternative sequence","location":{"start":{"value":264,"modifier":"EXACT"},"end":{"value":377,"modifier":"EXACT"}},"description":"in isoform 4","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11230166"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"}],"featureId":"VSP_058182","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":47,"modifier":"EXACT"},"end":{"value":47,"modifier":"EXACT"}},"description":"in dbSNP:rs56226603","featureCrossReferences":[{"database":"dbSNP","id":"rs56226603"}],"featureId":"VAR_061081","alternativeSequence":{"originalSequence":"D","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":134,"modifier":"EXACT"},"end":{"value":134,"modifier":"EXACT"}},"description":"in dbSNP:rs181090259","featureCrossReferences":[{"database":"dbSNP","id":"rs181090259"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14702039"}],"featureId":"VAR_075654","alternativeSequence":{"originalSequence":"R","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":284,"modifier":"EXACT"},"end":{"value":284,"modifier":"EXACT"}},"description":"in dbSNP:rs55901059","featureCrossReferences":[{"database":"dbSNP","id":"rs55901059"}],"featureId":"VAR_061082","alternativeSequence":{"originalSequence":"E","alternativeSequences":["D"]}},{"type":"Mutagenesis","location":{"start":{"value":152,"modifier":"EXACT"},"end":{"value":152,"modifier":"EXACT"}},"description":"Abolished ability to cleave IL18.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37993714"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":212,"modifier":"EXACT"},"end":{"value":212,"modifier":"EXACT"}},"description":"Abolished ability to cleave IL18; when associated with D-261.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37993714"}],"alternativeSequence":{"originalSequence":"I","alternativeSequences":["D"]}},{"type":"Mutagenesis","location":{"start":{"value":258,"modifier":"EXACT"},"end":{"value":258,"modifier":"EXACT"}},"description":"Loss of enzymatic activity. Loss of LPS-induced pyroptosis. No effect on the interaction with LPS. Decrease in cell death induced by TMEM214 overexpression. Does not support IL1B and IL18 secretion following UVB irradiation.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22246630"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23661706"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25119034"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28314590"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37993712"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37993714"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":258,"modifier":"EXACT"},"end":{"value":258,"modifier":"EXACT"}},"description":"Loss of autocatalysis.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7743998"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["S"]}},{"type":"Mutagenesis","location":{"start":{"value":261,"modifier":"EXACT"},"end":{"value":261,"modifier":"EXACT"}},"description":"Abolished ability to cleave IL18; when associated with D-212.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37993714"}],"alternativeSequence":{"originalSequence":"A","alternativeSequences":["D"]}},{"type":"Mutagenesis","location":{"start":{"value":267,"modifier":"EXACT"},"end":{"value":267,"modifier":"EXACT"}},"description":"Abolished interaction with Gasdermin-D (GSDMD) and ability to mediate its cleavage. Abolished binding to IL18 and ability to mediate its cleavage.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32109412"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37993712"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37993714"}],"alternativeSequence":{"originalSequence":"W","alternativeSequences":["L","N"]}},{"type":"Mutagenesis","location":{"start":{"value":269,"modifier":"EXACT"},"end":{"value":269,"modifier":"EXACT"}},"description":"Abolished binding to IL18 and ability to mediate its cleavage.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37993712"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["D"]}},{"type":"Mutagenesis","location":{"start":{"value":270,"modifier":"EXACT"},"end":{"value":270,"modifier":"EXACT"}},"description":"Abolished autoprocessing and ability to form a heterotetramer composed of Caspase-4 subunit p10 and Caspase-4 subunit p20, preventing ability to cleave GSDMD and induce pyroptosis.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32109412"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":289,"modifier":"EXACT"},"end":{"value":289,"modifier":"EXACT"}},"description":"Abolished autoprocessing.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37993714"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":291,"modifier":"EXACT"},"end":{"value":291,"modifier":"EXACT"}},"description":"Abolished interaction with Gasdermin-D (GSDMD) and ability to mediate its cleavage. Strongly decreased ability to cleave IL18.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32109412"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37993714"}],"alternativeSequence":{"originalSequence":"V","alternativeSequences":["N"]}},{"type":"Mutagenesis","location":{"start":{"value":293,"modifier":"EXACT"},"end":{"value":293,"modifier":"EXACT"}},"description":"Strongly decreased ability to cleave IL18.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37993714"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":314,"modifier":"EXACT"},"end":{"value":314,"modifier":"EXACT"}},"description":"Abolished ability to cleave Gasdermin-D (GSDMD). Abolished ability to cleave IL18.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34671164"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37993714"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":321,"modifier":"EXACT"},"end":{"value":321,"modifier":"EXACT"}},"description":"Abolished ability to cleave IL18.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37993714"}],"alternativeSequence":{"originalSequence":"I","alternativeSequences":["D"]}},{"type":"Mutagenesis","location":{"start":{"value":356,"modifier":"EXACT"},"end":{"value":356,"modifier":"EXACT"}},"description":"Abolished binding to IL18 and ability to mediate its cleavage.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37993712"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["D"]}},{"type":"Helix","location":{"start":{"value":106,"modifier":"EXACT"},"end":{"value":110,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WR6"}]},{"type":"Helix","location":{"start":{"value":111,"modifier":"EXACT"},"end":{"value":120,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WR6"}]},{"type":"Helix","location":{"start":{"value":122,"modifier":"EXACT"},"end":{"value":124,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WR6"}]},{"type":"Helix","location":{"start":{"value":126,"modifier":"EXACT"},"end":{"value":130,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WR6"}]},{"type":"Helix","location":{"start":{"value":131,"modifier":"EXACT"},"end":{"value":133,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WR6"}]},{"type":"Beta strand","location":{"start":{"value":136,"modifier":"EXACT"},"end":{"value":142,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WR6"}]},{"type":"Beta strand","location":{"start":{"value":147,"modifier":"EXACT"},"end":{"value":149,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WR6"}]},{"type":"Helix","location":{"start":{"value":155,"modifier":"EXACT"},"end":{"value":168,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WR6"}]},{"type":"Beta strand","location":{"start":{"value":171,"modifier":"EXACT"},"end":{"value":178,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WR6"}]},{"type":"Helix","location":{"start":{"value":181,"modifier":"EXACT"},"end":{"value":192,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WR6"}]},{"type":"Helix","location":{"start":{"value":195,"modifier":"EXACT"},"end":{"value":197,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WR6"}]},{"type":"Beta strand","location":{"start":{"value":203,"modifier":"EXACT"},"end":{"value":211,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WR6"}]},{"type":"Beta strand","location":{"start":{"value":213,"modifier":"EXACT"},"end":{"value":217,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WR6"}]},{"type":"Beta strand","location":{"start":{"value":223,"modifier":"EXACT"},"end":{"value":225,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WR6"}]},{"type":"Beta strand","location":{"start":{"value":228,"modifier":"EXACT"},"end":{"value":230,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WR6"}]},{"type":"Helix","location":{"start":{"value":231,"modifier":"EXACT"},"end":{"value":237,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WR6"}]},{"type":"Turn","location":{"start":{"value":240,"modifier":"EXACT"},"end":{"value":242,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WR6"}]},{"type":"Helix","location":{"start":{"value":244,"modifier":"EXACT"},"end":{"value":246,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WR6"}]},{"type":"Beta strand","location":{"start":{"value":251,"modifier":"EXACT"},"end":{"value":259,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WR6"}]},{"type":"Beta strand","location":{"start":{"value":260,"modifier":"EXACT"},"end":{"value":262,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8J6K"}]},{"type":"Beta strand","location":{"start":{"value":266,"modifier":"EXACT"},"end":{"value":269,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8SPB"}]},{"type":"Helix","location":{"start":{"value":293,"modifier":"EXACT"},"end":{"value":296,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WR6"}]},{"type":"Beta strand","location":{"start":{"value":299,"modifier":"EXACT"},"end":{"value":305,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WR6"}]},{"type":"Helix","location":{"start":{"value":307,"modifier":"EXACT"},"end":{"value":309,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WR1"}]},{"type":"Turn","location":{"start":{"value":310,"modifier":"EXACT"},"end":{"value":312,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WR5"}]},{"type":"Helix","location":{"start":{"value":313,"modifier":"EXACT"},"end":{"value":316,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6NRY"}]},{"type":"Beta strand","location":{"start":{"value":317,"modifier":"EXACT"},"end":{"value":320,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WR0"}]},{"type":"Helix","location":{"start":{"value":321,"modifier":"EXACT"},"end":{"value":333,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WR6"}]},{"type":"Turn","location":{"start":{"value":334,"modifier":"EXACT"},"end":{"value":336,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WR6"}]},{"type":"Helix","location":{"start":{"value":339,"modifier":"EXACT"},"end":{"value":349,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WR6"}]},{"type":"Turn","location":{"start":{"value":353,"modifier":"EXACT"},"end":{"value":355,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WR6"}]},{"type":"Helix","location":{"start":{"value":356,"modifier":"EXACT"},"end":{"value":358,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WR6"}]},{"type":"Beta strand","location":{"start":{"value":361,"modifier":"EXACT"},"end":{"value":364,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WR6"}]},{"type":"Beta strand","location":{"start":{"value":368,"modifier":"EXACT"},"end":{"value":370,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WR6"}]},{"type":"Initiator methionine","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"},"sequence":"P49662-2"},"description":"Removed","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"22814378"}]},{"type":"Modified residue","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":2,"modifier":"EXACT"},"sequence":"P49662-2"},"description":"N-acetylalanine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"22814378"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0007","category":"PTM","name":"Acetylation"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0256","category":"Cellular component","name":"Endoplasmic reticulum"},{"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"id":"KW-0391","category":"Biological process","name":"Immunity"},{"id":"KW-1271","category":"Cellular component","name":"Inflammasome"},{"id":"KW-0395","category":"Biological process","name":"Inflammatory response"},{"id":"KW-0399","category":"Biological process","name":"Innate immunity"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"id":"KW-1210","category":"Biological process","name":"Necrosis"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-0645","category":"Molecular function","name":"Protease"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"id":"KW-0788","category":"Molecular function","name":"Thiol protease"},{"id":"KW-0865","category":"PTM","name":"Zymogen"}],"references":[{"referenceNumber":1,"citation":{"id":"7743998","citationType":"journal article","authors":["Faucheu C.","Diu A.","Chan A.W.E.","Blanchet A.-M.","Miossec C.","Herve F.","Collard-Dutilleul V.","Gu Y.","Aldape R.A.","Lippke J.A.","Rocher C.","Su M.S.-S.","Livingston D.J.","Hercend T.","Lalanne J.-L."],"citationCrossReferences":[{"database":"PubMed","id":"7743998"},{"database":"DOI","id":"10.1002/j.1460-2075.1995.tb07183.x"}],"title":"A novel human protease similar to the interleukin-1 beta converting enzyme induces apoptosis in transfected cells.","publicationDate":"1995","journal":"EMBO J.","firstPage":"1914","lastPage":"1922","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)","FUNCTION","MUTAGENESIS OF CYS-258","3D-STRUCTURE MODELING","AUTOCATALYSIS","TISSUE SPECIFICITY"],"referenceComments":[{"value":"Placenta","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"7797592","citationType":"journal article","authors":["Munday N.A.","Vaillancourt J.P.","Ali A.","Casano F.J.","Miller D.K.","Molineaux S.M.","Yamin T.-T.","Yu V.L.","Nicholson D.W."],"citationCrossReferences":[{"database":"PubMed","id":"7797592"},{"database":"DOI","id":"10.1074/jbc.270.26.15870"}],"title":"Molecular cloning and pro-apoptotic activity of ICErelII and ICErelIII, members of the ICE/CED-3 family of cysteine proteases.","publicationDate":"1995","journal":"J. Biol. Chem.","firstPage":"15870","lastPage":"15876","volume":"270"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)","FUNCTION","TISSUE SPECIFICITY"],"referenceComments":[{"value":"Monocytic leukemia","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"7797510","citationType":"journal article","authors":["Kamens J.","Paskind M.","Hugunin M.","Talanian R.V.","Allen H.","Banach D.","Bump N.J.","Hackett M.C.","Johnston C.G.","Li P.","Mankovich J.A.","Terranova M.","Ghayur T."],"citationCrossReferences":[{"database":"PubMed","id":"7797510"},{"database":"DOI","id":"10.1074/jbc.270.25.15250"}],"title":"Identification and characterization of ICH-2, a novel member of the interleukin-1 beta-converting enzyme family of cysteine proteases.","publicationDate":"1995","journal":"J. Biol. Chem.","firstPage":"15250","lastPage":"15256","volume":"270"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)","FUNCTION","CATALYTIC ACTIVITY","TISSUE SPECIFICITY","AUTOCATALYTIC CLEAVAGE AT ASP-289","BIOPHYSICOCHEMICAL PROPERTIES"],"referenceComments":[{"value":"Thymus","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"CI-262QCG3LVE199","citationType":"submission","authors":["Fernandes-Alnemri T.","Litwack G.","Alnemri E.S."],"title":"Cloning of human ICE homolog Mih1.","publicationDate":"JUN-1995","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3)"],"referenceComments":[{"value":"T-cell","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 4 AND 5)","VARIANT CYS-134"],"referenceComments":[{"value":"Small intestine","type":"TISSUE"},{"value":"Trachea","type":"TISSUE"}]},{"referenceNumber":6,"citation":{"id":"CI-2OALQ4R1NJQ0G","citationType":"submission","authoringGroup":["NIEHS SNPs program"],"publicationDate":"MAY-2007","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":7,"citation":{"id":"16554811","citationType":"journal article","authors":["Taylor T.D.","Noguchi H.","Totoki Y.","Toyoda A.","Kuroki Y.","Dewar K.","Lloyd C.","Itoh T.","Takeda T.","Kim D.-W.","She X.","Barlow K.F.","Bloom T.","Bruford E.","Chang J.L.","Cuomo C.A.","Eichler E.","FitzGerald M.G.","Jaffe D.B.","LaButti K.","Nicol R.","Park H.-S.","Seaman C.","Sougnez C.","Yang X.","Zimmer A.R.","Zody M.C.","Birren B.W.","Nusbaum C.","Fujiyama A.","Hattori M.","Rogers J.","Lander E.S.","Sakaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"16554811"},{"database":"DOI","id":"10.1038/nature04632"}],"title":"Human chromosome 11 DNA sequence and analysis including novel gene identification.","publicationDate":"2006","journal":"Nature","firstPage":"497","lastPage":"500","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":8,"citation":{"id":"CI-56FT96O07V0QG","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"JUL-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":9,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"Testis","type":"TISSUE"}]},{"referenceNumber":10,"citation":{"id":"11230166","citationType":"journal article","authors":["Wiemann S.","Weil B.","Wellenreuther R.","Gassenhuber J.","Glassl S.","Ansorge W.","Boecher M.","Bloecker H.","Bauersachs S.","Blum H.","Lauber J.","Duesterhoeft A.","Beyer A.","Koehrer K.","Strack N.","Mewes H.-W.","Ottenwaelder B.","Obermaier B.","Tampe J.","Heubner D.","Wambutt R.","Korn B.","Klein M.","Poustka A."],"citationCrossReferences":[{"database":"PubMed","id":"11230166"},{"database":"DOI","id":"10.1101/gr.gr1547r"}],"title":"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.","publicationDate":"2001","journal":"Genome Res.","firstPage":"422","lastPage":"435","volume":"11"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 161-263 (ISOFORM 4)"],"referenceComments":[{"value":"Uterus","type":"TISSUE"}]},{"referenceNumber":11,"citation":{"id":"10986288","citationType":"journal article","authors":["Lin X.Y.","Choi M.S.","Porter A.G."],"citationCrossReferences":[{"database":"PubMed","id":"10986288"},{"database":"DOI","id":"10.1074/jbc.m007255200"}],"title":"Expression analysis of the human caspase-1 subfamily reveals specific regulation of the CASP5 gene by lipopolysaccharide and interferon-gamma.","publicationDate":"2000","journal":"J. Biol. Chem.","firstPage":"39920","lastPage":"39926","volume":"275"},"referencePositions":["TISSUE SPECIFICITY"]},{"referenceNumber":12,"citation":{"id":"15123740","citationType":"journal article","authors":["Hitomi J.","Katayama T.","Eguchi Y.","Kudo T.","Taniguchi M.","Koyama Y.","Manabe T.","Yamagishi S.","Bando Y.","Imaizumi K.","Tsujimoto Y.","Tohyama M."],"citationCrossReferences":[{"database":"PubMed","id":"15123740"},{"database":"DOI","id":"10.1083/jcb.200310015"}],"title":"Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Abeta-induced cell death.","publicationDate":"2004","journal":"J. Cell Biol.","firstPage":"347","lastPage":"356","volume":"165"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION","CLEAVAGE IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS"]},{"referenceNumber":13,"citation":{"id":"15326478","citationType":"journal article","authors":["Gaggero A.","De Ambrosis A.","Mezzanzanica D.","Piazza T.","Rubartelli A.","Figini M.","Canevari S.","Ferrini S."],"citationCrossReferences":[{"database":"PubMed","id":"15326478"},{"database":"DOI","id":"10.1038/sj.onc.1208036"}],"title":"A novel isoform of pro-interleukin-18 expressed in ovarian tumors is resistant to caspase-1 and -4 processing.","publicationDate":"2004","journal":"Oncogene","firstPage":"7552","lastPage":"7560","volume":"23"},"referencePositions":["FUNCTION"]},{"referenceNumber":14,"citation":{"id":"16893518","citationType":"journal article","authors":["Eckhart L.","Kittel C.","Gawlas S.","Gruber F.","Mildner M.","Jilma B.","Tschachler E."],"citationCrossReferences":[{"database":"PubMed","id":"16893518"},{"database":"DOI","id":"10.1016/j.bbrc.2006.07.104"}],"title":"Identification of a novel exon encoding the amino-terminus of the predominant caspase-5 variants.","publicationDate":"2006","journal":"Biochem. Biophys. Res. Commun.","firstPage":"682","lastPage":"688","volume":"348"},"referencePositions":["INDUCTION BY LPS"]},{"referenceNumber":15,"citation":{"id":"18669648","citationType":"journal article","authors":["Dephoure N.","Zhou C.","Villen J.","Beausoleil S.A.","Bakalarski C.E.","Elledge S.J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"18669648"},{"database":"DOI","id":"10.1073/pnas.0805139105"}],"title":"A quantitative atlas of mitotic phosphorylation.","publicationDate":"2008","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10762","lastPage":"10767","volume":"105"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-83","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":16,"citation":{"id":"18511561","citationType":"journal article","authors":["Hsu L.C.","Ali S.R.","McGillivray S.","Tseng P.H.","Mariathasan S.","Humke E.W.","Eckmann L.","Powell J.J.","Nizet V.","Dixit V.M.","Karin M."],"citationCrossReferences":[{"database":"PubMed","id":"18511561"},{"database":"DOI","id":"10.1073/pnas.0802726105"}],"title":"A NOD2-NALP1 complex mediates caspase-1-dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptide.","publicationDate":"2008","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"7803","lastPage":"7808","volume":"105"},"referencePositions":["INTERACTION WITH NOD2"]},{"referenceNumber":17,"citation":{"id":"20068231","citationType":"journal article","authors":["Olsen J.V.","Vermeulen M.","Santamaria A.","Kumar C.","Miller M.L.","Jensen L.J.","Gnad F.","Cox J.","Jensen T.S.","Nigg E.A.","Brunak S.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"20068231"},{"database":"DOI","id":"10.1126/scisignal.2000475"}],"title":"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.","publicationDate":"2010","journal":"Sci. Signal.","firstPage":"RA3","lastPage":"RA3","volume":"3"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-83","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":18,"citation":{"id":"22246630","citationType":"journal article","authors":["Sollberger G.","Strittmatter G.E.","Kistowska M.","French L.E.","Beer H.D."],"citationCrossReferences":[{"database":"PubMed","id":"22246630"},{"database":"DOI","id":"10.4049/jimmunol.1101620"}],"title":"Caspase-4 is required for activation of inflammasomes.","publicationDate":"2012","journal":"J. Immunol.","firstPage":"1992","lastPage":"2000","volume":"188"},"referencePositions":["FUNCTION","INTERACTION WITH CASP1","SUBCELLULAR LOCATION","TISSUE SPECIFICITY","MUTAGENESIS OF CYS-258"]},{"referenceNumber":19,"citation":{"id":"22814378","citationType":"journal article","authors":["Van Damme P.","Lasa M.","Polevoda B.","Gazquez C.","Elosegui-Artola A.","Kim D.S.","De Juan-Pardo E.","Demeyer K.","Hole K.","Larrea E.","Timmerman E.","Prieto J.","Arnesen T.","Sherman F.","Gevaert K.","Aldabe R."],"citationCrossReferences":[{"database":"PubMed","id":"22814378"},{"database":"DOI","id":"10.1073/pnas.1210303109"}],"title":"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.","publicationDate":"2012","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"12449","lastPage":"12454","volume":"109"},"referencePositions":["ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2 (ISOFORM 2)","CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS] (ISOFORM 2)","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":20,"citation":{"id":"23661706","citationType":"journal article","authors":["Li C.","Wei J.","Li Y.","He X.","Zhou Q.","Yan J.","Zhang J.","Liu Y.","Liu Y.","Shu H.B."],"citationCrossReferences":[{"database":"PubMed","id":"23661706"},{"database":"DOI","id":"10.1074/jbc.m113.458836"}],"title":"Transmembrane protein 214 (TMEM214) mediates endoplasmic reticulum stress-induced caspase 4 enzyme activation and apoptosis.","publicationDate":"2013","journal":"J. Biol. Chem.","firstPage":"17908","lastPage":"17917","volume":"288"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION","INTERACTION WITH TMEM214","MUTAGENESIS OF CYS-258"]},{"referenceNumber":21,"citation":{"id":"23516580","citationType":"journal article","authors":["Blasche S.","Mortl M.","Steuber H.","Siszler G.","Nisa S.","Schwarz F.","Lavrik I.","Gronewold T.M.","Maskos K.","Donnenberg M.S.","Ullmann D.","Uetz P.","Kogl M."],"citationCrossReferences":[{"database":"PubMed","id":"23516580"},{"database":"DOI","id":"10.1371/journal.pone.0058937"}],"title":"The E. coli effector protein NleF is a caspase inhibitor.","publicationDate":"2013","journal":"PLoS ONE","firstPage":"E58937","lastPage":"E58937","volume":"8"},"referencePositions":["INTERACTION WITH E.COLI NLEF (MICROBIAL INFECTION)","CATALYTIC ACTIVITY","FUNCTION","ACTIVITY REGULATION (MICROBIAL INFECTION)"]},{"referenceNumber":22,"citation":{"id":"25121752","citationType":"journal article","authors":["Knodler L.A.","Crowley S.M.","Sham H.P.","Yang H.","Wrande M.","Ma C.","Ernst R.K.","Steele-Mortimer O.","Celli J.","Vallance B.A."],"citationCrossReferences":[{"database":"PubMed","id":"25121752"},{"database":"DOI","id":"10.1016/j.chom.2014.07.002"}],"title":"Noncanonical inflammasome activation of caspase-4/caspase-11 mediates epithelial defenses against enteric bacterial pathogens.","publicationDate":"2014","journal":"Cell Host Microbe","firstPage":"249","lastPage":"256","volume":"16"},"referencePositions":["FUNCTION","TISSUE SPECIFICITY","INDUCTION BY LPS"]},{"referenceNumber":23,"citation":{"id":"24879791","citationType":"journal article","authors":["Kajiwara Y.","Schiff T.","Voloudakis G.","Gama Sosa M.A.","Elder G.","Bozdagi O.","Buxbaum J.D."],"citationCrossReferences":[{"database":"PubMed","id":"24879791"},{"database":"DOI","id":"10.4049/jimmunol.1303424"}],"title":"A critical role for human caspase-4 in endotoxin sensitivity.","publicationDate":"2014","journal":"J. Immunol.","firstPage":"335","lastPage":"343","volume":"193"},"referencePositions":["FUNCTION","INDUCTION BY LPS"]},{"referenceNumber":24,"citation":{"id":"25119034","citationType":"journal article","authors":["Shi J.","Zhao Y.","Wang Y.","Gao W.","Ding J.","Li P.","Hu L.","Shao F."],"citationCrossReferences":[{"database":"PubMed","id":"25119034"},{"database":"DOI","id":"10.1038/nature13683"}],"title":"Inflammatory caspases are innate immune receptors for intracellular LPS.","publicationDate":"2014","journal":"Nature","firstPage":"187","lastPage":"192","volume":"514"},"referencePositions":["FUNCTION","OLIGOMERIZATION","INTERACTION WITH LPS","ACTIVITY REGULATION","SUBCELLULAR LOCATION","DOMAIN","MUTAGENESIS OF CYS-258"]},{"referenceNumber":25,"citation":{"id":"26174085","citationType":"journal article","authors":["Schmid-Burgk J.L.","Gaidt M.M.","Schmidt T.","Ebert T.S.","Bartok E.","Hornung V."],"citationCrossReferences":[{"database":"PubMed","id":"26174085"},{"database":"DOI","id":"10.1002/eji.201545523"}],"title":"Caspase-4 mediates non-canonical activation of the NLRP3 inflammasome in human myeloid cells.","publicationDate":"2015","journal":"Eur. J. Immunol.","firstPage":"2911","lastPage":"2917","volume":"45"},"referencePositions":["FUNCTION"]},{"referenceNumber":26,"citation":{"id":"26173988","citationType":"journal article","authors":["Baker P.J.","Boucher D.","Bierschenk D.","Tebartz C.","Whitney P.G.","D'Silva D.B.","Tanzer M.C.","Monteleone M.","Robertson A.A.","Cooper M.A.","Alvarez-Diaz S.","Herold M.J.","Bedoui S.","Schroder K.","Masters S.L."],"citationCrossReferences":[{"database":"PubMed","id":"26173988"},{"database":"DOI","id":"10.1002/eji.201545655"}],"title":"NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5.","publicationDate":"2015","journal":"Eur. J. Immunol.","firstPage":"2918","lastPage":"2926","volume":"45"},"referencePositions":["FUNCTION"]},{"referenceNumber":27,"citation":{"id":"26508369","citationType":"journal article","authors":["Vigano E.","Diamond C.E.","Spreafico R.","Balachander A.","Sobota R.M.","Mortellaro A."],"citationCrossReferences":[{"database":"PubMed","id":"26508369"},{"database":"DOI","id":"10.1038/ncomms9761"}],"title":"Human caspase-4 and caspase-5 regulate the one-step non-canonical inflammasome activation in monocytes.","publicationDate":"2015","journal":"Nat. Commun.","firstPage":"8761","lastPage":"8761","volume":"6"},"referencePositions":["FUNCTION","INDUCTION BY LPS"]},{"referenceNumber":28,"citation":{"id":"26375003","citationType":"journal article","authors":["Shi J.","Zhao Y.","Wang K.","Shi X.","Wang Y.","Huang H.","Zhuang Y.","Cai T.","Wang F.","Shao F."],"citationCrossReferences":[{"database":"PubMed","id":"26375003"},{"database":"DOI","id":"10.1038/nature15514"}],"title":"Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death.","publicationDate":"2015","journal":"Nature","firstPage":"660","lastPage":"665","volume":"526"},"referencePositions":["FUNCTION","GSDMD CLEAVAGE"]},{"referenceNumber":29,"citation":{"id":"25695505","citationType":"journal article","authors":["Yang H.J.","Wang M.","Wang L.","Cheng B.F.","Lin X.Y.","Feng Z.W."],"citationCrossReferences":[{"database":"PubMed","id":"25695505"},{"database":"DOI","id":"10.1371/journal.pone.0117953"}],"title":"NF-kappaB regulates caspase-4 expression and sensitizes neuroblastoma cells to Fas-induced apoptosis.","publicationDate":"2015","journal":"PLoS ONE","firstPage":"E0117953","lastPage":"E0117953","volume":"10"},"referencePositions":["INDUCTION BY NF-KAPPA-B"]},{"referenceNumber":30,"citation":{"id":"25964352","citationType":"journal article","authors":["Casson C.N.","Yu J.","Reyes V.M.","Taschuk F.O.","Yadav A.","Copenhaver A.M.","Nguyen H.T.","Collman R.G.","Shin S."],"citationCrossReferences":[{"database":"PubMed","id":"25964352"},{"database":"DOI","id":"10.1073/pnas.1421699112"}],"title":"Human caspase-4 mediates noncanonical inflammasome activation against gram-negative bacterial pathogens.","publicationDate":"2015","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"6688","lastPage":"6693","volume":"112"},"referencePositions":["FUNCTION","INDUCTION BY LPS AND IFNB1"]},{"referenceNumber":31,"citation":{"id":"28314590","citationType":"journal article","authors":["Wang Y.","Ning X.","Gao P.","Wu S.","Sha M.","Lv M.","Zhou X.","Gao J.","Fang R.","Meng G.","Su X.","Jiang Z."],"citationCrossReferences":[{"database":"PubMed","id":"28314590"},{"database":"DOI","id":"10.1016/j.immuni.2017.02.011"}],"title":"Inflammasome activation triggers caspase-1-mediated cleavage of cGAS to regulate responses to DNA virus infection.","publicationDate":"2017","journal":"Immunity","firstPage":"393","lastPage":"404","volume":"46"},"referencePositions":["FUNCTION","MUTAGENESIS OF CYS-258"]},{"referenceNumber":32,"citation":{"id":"29077095","citationType":"journal article","authors":["Jun H.K.","Jung Y.J.","Ji S.","An S.J.","Choi B.K."],"citationCrossReferences":[{"database":"PubMed","id":"29077095"},{"database":"DOI","id":"10.1038/cdd.2017.167"}],"title":"Caspase-4 activation by a bacterial surface protein is mediated by cathepsin G in human gingival fibroblasts.","publicationDate":"2018","journal":"Cell Death Differ.","firstPage":"380","lastPage":"391","volume":"25"},"referencePositions":["FUNCTION","INTERACTION WITH CTSG"]},{"referenceNumber":33,"citation":{"id":"29520027","citationType":"journal article","authors":["Chu L.H.","Indramohan M.","Ratsimandresy R.A.","Gangopadhyay A.","Morris E.P.","Monack D.M.","Dorfleutner A.","Stehlik C."],"citationCrossReferences":[{"database":"PubMed","id":"29520027"},{"database":"DOI","id":"10.1038/s41467-018-03409-3"}],"title":"The oxidized phospholipid oxPAPC protects from septic shock by targeting the non-canonical inflammasome in macrophages.","publicationDate":"2018","journal":"Nat. Commun.","firstPage":"996","lastPage":"996","volume":"9"},"referencePositions":["FUNCTION","ACTIVITY REGULATION"]},{"referenceNumber":34,"citation":{"id":"31268602","citationType":"journal article","authors":["Fisch D.","Bando H.","Clough B.","Hornung V.","Yamamoto M.","Shenoy A.R.","Frickel E.M."],"citationCrossReferences":[{"database":"PubMed","id":"31268602"},{"database":"DOI","id":"10.15252/embj.2018100926"}],"title":"Human GBP1 is a microbe-specific gatekeeper of macrophage apoptosis and pyroptosis.","publicationDate":"2019","journal":"EMBO J.","firstPage":"e100926","lastPage":"e100926","volume":"38"},"referencePositions":["FUNCTION"]},{"referenceNumber":35,"citation":{"id":"30692621","citationType":"journal article","authors":["Choi Y.J.","Kim S.","Choi Y.","Nielsen T.B.","Yan J.","Lu A.","Ruan J.","Lee H.R.","Wu H.","Spellberg B.","Jung J.U."],"citationCrossReferences":[{"database":"PubMed","id":"30692621"},{"database":"DOI","id":"10.1038/s41590-018-0303-z"}],"title":"SERPINB1-mediated checkpoint of inflammatory caspase activation.","publicationDate":"2019","journal":"Nat. Immunol.","firstPage":"276","lastPage":"287","volume":"20"},"referencePositions":["INTERACTION WITH SERPINB1"]},{"referenceNumber":36,"citation":{"id":"32510692","citationType":"journal article","authors":["Kutsch M.","Sistemich L.","Lesser C.F.","Goldberg M.B.","Herrmann C.","Coers J."],"citationCrossReferences":[{"database":"PubMed","id":"32510692"},{"database":"DOI","id":"10.15252/embj.2020104926"}],"title":"Direct binding of polymeric GBP1 to LPS disrupts bacterial cell envelope functions.","publicationDate":"2020","journal":"EMBO J.","firstPage":"e104926","lastPage":"e104926","volume":"39"},"referencePositions":["FUNCTION"]},{"referenceNumber":37,"citation":{"id":"32581219","citationType":"journal article","authors":["Santos J.C.","Boucher D.","Schneider L.K.","Demarco B.","Dilucca M.","Shkarina K.","Heilig R.","Chen K.W.","Lim R.Y.H.","Broz P."],"citationCrossReferences":[{"database":"PubMed","id":"32581219"},{"database":"DOI","id":"10.1038/s41467-020-16889-z"}],"title":"Human GBP1 binds LPS to initiate assembly of a caspase-4 activating platform on cytosolic bacteria.","publicationDate":"2020","journal":"Nat. Commun.","firstPage":"3276","lastPage":"3276","volume":"11"},"referencePositions":["FUNCTION"]},{"referenceNumber":38,"citation":{"id":"33377178","citationType":"journal article","authors":["Tian X.X.","Li R.","Liu C.","Liu F.","Yang L.J.","Wang S.P.","Wang C.L."],"citationCrossReferences":[{"database":"PubMed","id":"33377178"},{"database":"DOI","id":"10.1111/iej.13469"}],"title":"NLRP6-caspase 4 inflammasome activation in response to cariogenic bacterial lipoteichoic acid in human dental pulp inflammation.","publicationDate":"2021","journal":"Int. Endod. J.","firstPage":"916","lastPage":"925","volume":"54"},"referencePositions":["FUNCTION"]},{"referenceNumber":39,"citation":{"id":"34671164","citationType":"journal article","authors":["Li Z.","Liu W.","Fu J.","Cheng S.","Xu Y.","Wang Z.","Liu X.","Shi X.","Liu Y.","Qi X.","Liu X.","Ding J.","Shao F."],"citationCrossReferences":[{"database":"PubMed","id":"34671164"},{"database":"DOI","id":"10.1038/s41586-021-04020-1"}],"title":"Shigella evades pyroptosis by arginine ADP-riboxanation of caspase-11.","publicationDate":"2021","journal":"Nature","firstPage":"290","lastPage":"295","volume":"599"},"referencePositions":["FUNCTION","PROTEOLYTIC CLEAVAGE","ADP-RIBOXANATION AT ARG-314 (MICROBIAL INFECTION)","MUTAGENESIS OF ARG-314"]},{"referenceNumber":40,"citation":{"id":"35338844","citationType":"journal article","authors":["Peng T.","Tao X.","Xia Z.","Hu S.","Xue J.","Zhu Q.","Pan X.","Zhang Q.","Li S."],"citationCrossReferences":[{"database":"PubMed","id":"35338844"},{"database":"DOI","id":"10.1016/j.molcel.2022.03.010"}],"title":"Pathogen hijacks programmed cell death signaling by arginine ADPR-deacylization of caspases.","publicationDate":"2022","journal":"Mol. Cell","firstPage":"1806","lastPage":"1820","volume":"82"},"referencePositions":["ADP-RIBOXANATION AT ARG-314 (MICROBIAL INFECTION)"]},{"referenceNumber":41,"citation":{"id":"37001519","citationType":"journal article","authors":["Zhu F.","Ma J.","Li W.","Liu Q.","Qin X.","Qian Y.","Wang C.","Zhang Y.","Li Y.","Jiang D.","Wang S.","Xia P."],"citationCrossReferences":[{"database":"PubMed","id":"37001519"},{"database":"DOI","id":"10.1016/j.immuni.2023.03.003"}],"title":"The orphan receptor Nur77 binds cytoplasmic LPS to activate the non-canonical NLRP3 inflammasome.","publicationDate":"2023","journal":"Immunity","firstPage":"753","lastPage":"767","volume":"56"},"referencePositions":["FUNCTION","IDENTIFICATION BY MASS SPECTROMETRY"]},{"referenceNumber":42,"citation":{"id":"37014865","citationType":"journal article","authors":["Goers L.","Kim K.","Stedman T.C.","Canning P.J.","Mou X.","Ernst N.H.","Coers J.","Lesser C.F."],"citationCrossReferences":[{"database":"PubMed","id":"37014865"},{"database":"DOI","id":"10.1073/pnas.2218469120"}],"title":"Shigella IpaH9.8 limits GBP1-dependent LPS release from intracytosolic bacteria to suppress caspase-4 activation.","publicationDate":"2023","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"e2218469120","lastPage":"e2218469120","volume":"120"},"referencePositions":["ADP-RIBOXANATION (MICROBIAL INFECTION)"]},{"referenceNumber":43,"citation":{"id":"32109412","citationType":"journal article","authors":["Wang K.","Sun Q.","Zhong X.","Zeng M.","Zeng H.","Shi X.","Li Z.","Wang Y.","Zhao Q.","Shao F.","Ding J."],"citationCrossReferences":[{"database":"PubMed","id":"32109412"},{"database":"DOI","id":"10.1016/j.cell.2020.02.002"}],"title":"Structural mechanism for GSDMD targeting by autoprocessed caspases in pyroptosis.","publicationDate":"2020","journal":"Cell","firstPage":"941","lastPage":"955","volume":"180"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (3.61 ANGSTROMS) OF 105-289 AND 290-377 IN COMPLEX WITH GSDMD","FUNCTION","SUBUNIT","PROTEOLYTIC CLEAVAGE","MUTAGENESIS OF TRP-267; ASP-270 AND VAL-291"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"6KMZ"}]},{"referenceNumber":44,"citation":{"id":"36624349","citationType":"journal article","authors":["Hou Y.","Zeng H.","Li Z.","Feng N.","Meng F.","Xu Y.","Li L.","Shao F.","Ding J."],"citationCrossReferences":[{"database":"PubMed","id":"36624349"},{"database":"DOI","id":"10.1038/s41594-022-00888-3"}],"title":"Structural mechanisms of calmodulin activation of Shigella effector OspC3 to ADP-riboxanate caspase-4/11 and block pyroptosis.","publicationDate":"2023","journal":"Nat. Struct. Mol. Biol.","firstPage":"261","lastPage":"272","volume":"30"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.96 ANGSTROMS) OF 102-377 IN COMPLEX WITH CALMODULIN AND S.FLEXNERI OSPC3","ADP-RIBOXANATION AT ARG-314 (MICROBIAL INFECTION)"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"7WR0"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7WR1"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7WR4"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7WR5"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7WR6"}]},{"referenceNumber":45,"citation":{"id":"37993712","citationType":"journal article","authors":["Devant P.","Dong Y.","Mintseris J.","Ma W.","Gygi S.P.","Wu H.","Kagan J.C."],"citationCrossReferences":[{"database":"PubMed","id":"37993712"},{"database":"DOI","id":"10.1038/s41586-023-06751-9"}],"title":"Structural insights into cytokine cleavage by inflammatory caspase-4.","publicationDate":"2023","journal":"Nature","firstPage":"0","lastPage":"0","volume":"0"},"referencePositions":["STRUCTURE BY ELECTRON MICROSCOPY (3.2 ANGSTROMS) OF 94-270 AND 290-377 IN COMPLEX WITH IL18","FUNCTION","CATALYTIC ACTIVITY","ACTIVE SITE","MUTAGENESIS OF CYS-258; TRP-267; ARG-269 AND LYS-356"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"8SPB"}]},{"referenceNumber":46,"citation":{"id":"37993714","citationType":"journal article","authors":["Shi X.","Sun Q.","Hou Y.","Zeng H.","Cao Y.","Dong M.","Ding J.","Shao F."],"citationCrossReferences":[{"database":"PubMed","id":"37993714"},{"database":"DOI","id":"10.1038/s41586-023-06742-w"}],"title":"Recognition and maturation of IL-18 by caspase-4 noncanonical inflammasome.","publicationDate":"2023","journal":"Nature","firstPage":"0","lastPage":"0","volume":"0"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (3.12 ANGSTROMS) OF 102-270 AND 290-377 IN COMPLEX WITH IL18 AND S.FLEXNERI OSPC3","FUNCTION","CATALYTIC ACTIVITY","SUBUNIT","PROTEOLYTIC CLEAVAGE","ACTIVE SITE","MUTAGENESIS OF ARG-152; ILE-212; CYS-258; ALA-261; TRP-267; ASP-289; VAL-291; LYS-293; ARG-314 AND ILE-321"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"8J6K"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"Z48810","properties":[{"key":"ProteinId","value":"CAA88750.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"U28014","properties":[{"key":"ProteinId","value":"AAA75171.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"U25804","properties":[{"key":"ProteinId","value":"AAA86890.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"U28976","properties":[{"key":"ProteinId","value":"AAC99850.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"U28977","properties":[{"key":"ProteinId","value":"AAC99851.1"},{"key":"Status","value":"ALT_FRAME"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"U28978","properties":[{"key":"ProteinId","value":"AAC99852.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"U28979","properties":[{"key":"ProteinId","value":"AAC99853.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"U28979","properties":[{"key":"ProteinId","value":"AAC99854.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK057094","properties":[{"key":"ProteinId","value":"BAG51861.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK296081","properties":[{"key":"ProteinId","value":"BAG58837.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK304222","properties":[{"key":"ProteinId","value":"BAG65094.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"EF636667","properties":[{"key":"ProteinId","value":"ABR09278.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AP001153","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AP002004","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471065","properties":[{"key":"ProteinId","value":"EAW67050.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471065","properties":[{"key":"ProteinId","value":"EAW67051.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471065","properties":[{"key":"ProteinId","value":"EAW67052.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC017839","properties":[{"key":"ProteinId","value":"AAH17839.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AL050391","properties":[{"key":"ProteinId","value":"CAB43686.2"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS41704.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P49662-2"},{"database":"CCDS","id":"CCDS8327.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P49662-1"},{"database":"PIR","id":"A57511","properties":[{"key":"EntryName","value":"A57511"}]},{"database":"RefSeq","id":"NP_001216.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001225.4"}],"isoformId":"P49662-1"},{"database":"RefSeq","id":"NP_150649.1","properties":[{"key":"NucleotideSequenceId","value":"NM_033306.3"}],"isoformId":"P49662-2"},{"database":"RefSeq","id":"XP_011541321.1","properties":[{"key":"NucleotideSequenceId","value":"XM_011543019.2"}]},{"database":"PDB","id":"6KMZ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.61 A"},{"key":"Chains","value":"A/B/C/D=105-377"}]},{"database":"PDB","id":"6NRY","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.18 A"},{"key":"Chains","value":"A=92-377"}]},{"database":"PDB","id":"7WR0","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.80 A"},{"key":"Chains","value":"A=102-377"}]},{"database":"PDB","id":"7WR1","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.13 A"},{"key":"Chains","value":"A/B=102-377"}]},{"database":"PDB","id":"7WR4","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.75 A"},{"key":"Chains","value":"C=102-377"}]},{"database":"PDB","id":"7WR5","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.10 A"},{"key":"Chains","value":"C=102-377"}]},{"database":"PDB","id":"7WR6","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.96 A"},{"key":"Chains","value":"A=102-377"}]},{"database":"PDB","id":"8J6K","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.12 A"},{"key":"Chains","value":"A=102-270, a=290-377"}]},{"database":"PDB","id":"8SPB","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.20 A"},{"key":"Chains","value":"A/a=94-270, B/b=290-377"}]},{"database":"PDBsum","id":"6KMZ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6NRY","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7WR0","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7WR1","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7WR4","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7WR5","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7WR6","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8J6K","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8SPB","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"P49662","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-40678","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P49662","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"107287","properties":[{"key":"Interactions","value":"49"}]},{"database":"DIP","id":"DIP-44806N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P49662","properties":[{"key":"Number of interactors","value":"728"}]},{"database":"IntAct","id":"P49662","properties":[{"key":"Interactions","value":"11"}]},{"database":"MINT","id":"P49662","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-CASP4","properties":[{"key":"Evidences","value":"3 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000388566","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"P49662","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL2226","properties":[{"key":"Description","value":"-"}]},{"database":"DrugBank","id":"DB06255","properties":[{"key":"GenericName","value":"Incadronic acid"}]},{"database":"GuidetoPHARMACOLOGY","id":"1620","properties":[{"key":"Description","value":"-"}]},{"database":"MEROPS","id":"C14.007","properties":[{"key":"Description","value":"-"}]},{"database":"iPTMnet","id":"P49662","properties":[{"key":"Description","value":"-"}]},{"database":"MetOSite","id":"P49662","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"P49662","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"CASP4","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"1352420","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"P49662","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"P49662","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000388566","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P49662","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"56043","properties":[{"key":"Description","value":"-"}],"isoformId":"P49662-1"},{"database":"ProteomicsDB","id":"56044","properties":[{"key":"Description","value":"-"}],"isoformId":"P49662-2"},{"database":"Pumba","id":"P49662","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"18094","properties":[{"key":"antibodies","value":"744 antibodies from 44 providers"}]},{"database":"DNASU","id":"837","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000393150.7","properties":[{"key":"ProteinId","value":"ENSP00000376857.3"},{"key":"GeneId","value":"ENSG00000196954.14"}],"isoformId":"P49662-2"},{"database":"Ensembl","id":"ENST00000444739.7","properties":[{"key":"ProteinId","value":"ENSP00000388566.2"},{"key":"GeneId","value":"ENSG00000196954.14"}],"isoformId":"P49662-1"},{"database":"GeneID","id":"837","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:837","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000444739.7","properties":[{"key":"ProteinId","value":"ENSP00000388566.2"},{"key":"RefSeqNucleotideId","value":"NM_001225.4"},{"key":"RefSeqProteinId","value":"NP_001216.1"}]},{"database":"UCSC","id":"uc001pib.2","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"P49662-1"},{"database":"AGR","id":"HGNC:1505","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA26088","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"837","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"837","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"CASP4","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:1505","properties":[{"key":"GeneName","value":"CASP4"}]},{"database":"HPA","id":"ENSG00000196954","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MIM","id":"602664","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000196954","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000196954","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG3573","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000161497","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_036904_0_1_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P49662","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"ACRGANH","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"6097640at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"P49662","properties":[{"key":"Number of GO annotations","value":"5 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"P49662","properties":[{"key":"Description","value":"-"}]},{"database":"BioCyc","id":"MetaCyc:HS06388-MONOMER","properties":[{"key":"Description","value":"-"}]},{"database":"BRENDA","id":"3.4.22.57","properties":[{"key":"OrganismId","value":"2681"}]},{"database":"PathwayCommons","id":"P49662","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-168638","properties":[{"key":"PathwayName","value":"NOD1/2 Signaling Pathway"}]},{"database":"Reactome","id":"R-HSA-5620971","properties":[{"key":"PathwayName","value":"Pyroptosis"}]},{"database":"Reactome","id":"R-HSA-9948001","properties":[{"key":"PathwayName","value":"CASP4 inflammasome assembly"}]},{"database":"Reactome","id":"R-HSA-9956593","properties":[{"key":"PathwayName","value":"Enterobacterial factors antagonize host defense"}]},{"database":"Reactome","id":"R-HSA-9960519","properties":[{"key":"PathwayName","value":"CASP4-mediated substrate cleavage"}]},{"database":"SABIO-RK","id":"P49662","properties":[{"key":"Description","value":"-"}]},{"database":"SignaLink","id":"P49662","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"P49662","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000196954","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"837","properties":[{"key":"hits","value":"15 hits in 1158 CRISPR screens"}]},{"database":"ChiTaRS","id":"CASP4","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GenomeRNAi","id":"837","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"P49662","properties":[{"key":"DevelopmentLevel","value":"Tchem"}]},{"database":"PRO","id":"PR:P49662","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 11"}]},{"database":"RNAct","id":"P49662","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000196954","properties":[{"key":"ExpressionPatterns","value":"Expressed in monocyte and 178 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"P49662","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0061702","properties":[{"key":"GoTerm","value":"C:canonical inflammasome complex"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25119034"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26508369"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IDA:UniProt"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"23661706"}]},{"database":"GO","id":"GO:0005783","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum"},{"key":"GoEvidenceType","value":"IDA:ParkinsonsUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15123740"}]},{"database":"GO","id":"GO:0005789","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum membrane"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15123740"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23661706"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22246630"}]},{"database":"GO","id":"GO:0005739","properties":[{"key":"GoTerm","value":"C:mitochondrion"},{"key":"GoEvidenceType","value":"IDA:ParkinsonsUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15123740"}]},{"database":"GO","id":"GO:0072558","properties":[{"key":"GoTerm","value":"C:NLRP1 inflammasome complex"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0160074","properties":[{"key":"GoTerm","value":"C:non-canonical inflammasome complex"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"25119034"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"31268602"}]},{"database":"GO","id":"GO:0032991","properties":[{"key":"GoTerm","value":"C:protein-containing complex"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16920334"}]},{"database":"GO","id":"GO:0050700","properties":[{"key":"GoTerm","value":"F:CARD domain binding"},{"key":"GoEvidenceType","value":"IPI:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"16920334"}]},{"database":"GO","id":"GO:0004197","properties":[{"key":"GoTerm","value":"F:cysteine-type endopeptidase activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16920334"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"32109412"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"34671164"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"37993712"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"37993714"}]},{"database":"GO","id":"GO:0008289","properties":[{"key":"GoTerm","value":"F:lipid binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"25119034"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"32510692"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"37993712"}]},{"database":"GO","id":"GO:0001530","properties":[{"key":"GoTerm","value":"F:lipopolysaccharide binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"25119034"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"37993712"}]},{"database":"GO","id":"GO:0006915","properties":[{"key":"GoTerm","value":"P:apoptotic process"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"7743998"},{"evidenceCode":"ECO:0000304","source":"PubMed","id":"7797510"}]},{"database":"GO","id":"GO:1904646","properties":[{"key":"GoTerm","value":"P:cellular response to amyloid-beta"},{"key":"GoEvidenceType","value":"IMP:ParkinsonsUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"15123740"}]},{"database":"GO","id":"GO:0042742","properties":[{"key":"GoTerm","value":"P:defense response to bacterium"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"32510692"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"37993712"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"37993714"}]},{"database":"GO","id":"GO:0050830","properties":[{"key":"GoTerm","value":"P:defense response to Gram-positive bacterium"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"33377178"}]},{"database":"GO","id":"GO:0097193","properties":[{"key":"GoTerm","value":"P:intrinsic apoptotic signaling pathway"},{"key":"GoEvidenceType","value":"IMP:ParkinsonsUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"15123740"}]},{"database":"GO","id":"GO:0070059","properties":[{"key":"GoTerm","value":"P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress"},{"key":"GoEvidenceType","value":"IMP:ParkinsonsUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"15123740"}]},{"database":"GO","id":"GO:0160075","properties":[{"key":"GoTerm","value":"P:non-canonical inflammasome complex assembly"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"25119034"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"31268602"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"32510692"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"37993712"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"37993714"}]},{"database":"GO","id":"GO:0050729","properties":[{"key":"GoTerm","value":"P:positive regulation of inflammatory response"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"33377178"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"34671164"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"37993712"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"37993714"}]},{"database":"GO","id":"GO:2000494","properties":[{"key":"GoTerm","value":"P:positive regulation of interleukin-18-mediated signaling pathway"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"33377178"}]},{"database":"GO","id":"GO:0043525","properties":[{"key":"GoTerm","value":"P:positive regulation of neuron apoptotic process"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:1903265","properties":[{"key":"GoTerm","value":"P:positive regulation of tumor necrosis factor-mediated signaling pathway"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16920334"}]},{"database":"GO","id":"GO:0016540","properties":[{"key":"GoTerm","value":"P:protein autoprocessing"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"32109412"}]},{"database":"GO","id":"GO:0051604","properties":[{"key":"GoTerm","value":"P:protein maturation"},{"key":"GoEvidenceType","value":"IDA:UniProt"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"25119034"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"26375003"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"34671164"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"37993712"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"37993714"}]},{"database":"GO","id":"GO:0006508","properties":[{"key":"GoTerm","value":"P:proteolysis"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"7797510"}]},{"database":"GO","id":"GO:0070269","properties":[{"key":"GoTerm","value":"P:pyroptotic inflammatory response"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"31268602"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"32109412"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"34671164"}]},{"database":"GO","id":"GO:0050727","properties":[{"key":"GoTerm","value":"P:regulation of inflammatory response"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"32109412"}]},{"database":"CDD","id":"cd08325","properties":[{"key":"EntryName","value":"CARD_CASP1-like"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd00032","properties":[{"key":"EntryName","value":"CASc"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.70.1470:FF:000003","properties":[{"key":"EntryName","value":"Caspase-1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.1460:FF:000007","properties":[{"key":"EntryName","value":"Caspase-1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.533.10:FF:000073","properties":[{"key":"EntryName","value":"Inactive caspase-12"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.1460","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.533.10","properties":[{"key":"EntryName","value":"Death Domain, Fas"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001315","properties":[{"key":"EntryName","value":"CARD"}]},{"database":"InterPro","id":"IPR029030","properties":[{"key":"EntryName","value":"Caspase-like_dom_sf"}]},{"database":"InterPro","id":"IPR033139","properties":[{"key":"EntryName","value":"Caspase_cys_AS"}]},{"database":"InterPro","id":"IPR016129","properties":[{"key":"EntryName","value":"Caspase_his_AS"}]},{"database":"InterPro","id":"IPR011029","properties":[{"key":"EntryName","value":"DEATH-like_dom_sf"}]},{"database":"InterPro","id":"IPR002398","properties":[{"key":"EntryName","value":"Pept_C14"}]},{"database":"InterPro","id":"IPR011600","properties":[{"key":"EntryName","value":"Pept_C14_caspase"}]},{"database":"InterPro","id":"IPR002138","properties":[{"key":"EntryName","value":"Pept_C14_p10"}]},{"database":"InterPro","id":"IPR001309","properties":[{"key":"EntryName","value":"Pept_C14_p20"}]},{"database":"InterPro","id":"IPR015917","properties":[{"key":"EntryName","value":"Pept_C14A"}]},{"database":"PANTHER","id":"PTHR47901","properties":[{"key":"EntryName","value":"CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 18"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR47901:SF3","properties":[{"key":"EntryName","value":"CASPASE-1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00619","properties":[{"key":"EntryName","value":"CARD"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00656","properties":[{"key":"EntryName","value":"Peptidase_C14"},{"key":"MatchStatus","value":"1"}]},{"database":"PIRSF","id":"PIRSF038001","properties":[{"key":"EntryName","value":"Caspase_ICE"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00376","properties":[{"key":"EntryName","value":"IL1BCENZYME"}]},{"database":"SMART","id":"SM00114","properties":[{"key":"EntryName","value":"CARD"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00115","properties":[{"key":"EntryName","value":"CASc"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52129","properties":[{"key":"EntryName","value":"Caspase-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF47986","properties":[{"key":"EntryName","value":"DEATH domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50209","properties":[{"key":"EntryName","value":"CARD"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01122","properties":[{"key":"EntryName","value":"CASPASE_CYS"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01121","properties":[{"key":"EntryName","value":"CASPASE_HIS"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50207","properties":[{"key":"EntryName","value":"CASPASE_P10"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50208","properties":[{"key":"EntryName","value":"CASPASE_P20"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAEGNHRKKPLKVLESLGKDFLTGVLDNLVEQNVLNWKEEEKKKYYDAKTEDKVRVMADSMQEKQRMAGQMLLQTFFNIDQISPNKKAHPNMEAGPPESGESTDALKLCPHEEFLRLCKERAEEIYPIKERNNRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDFIAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAKAQMPTIERLSMTRYFYLFPGN","length":377,"molWeight":43262,"crc64":"DC7CCEC6E9D483EB","md5":"A57DEABB00D5EB1CF6EAA154F1D44897"},"extraAttributes":{"countByCommentType":{"FUNCTION":2,"CATALYTIC ACTIVITY":1,"ACTIVITY REGULATION":1,"BIOPHYSICOCHEMICAL PROPERTIES":1,"SUBUNIT":5,"INTERACTION":1,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":5,"TISSUE SPECIFICITY":1,"INDUCTION":1,"DOMAIN":1,"PTM":2,"MISCELLANEOUS":1,"SIMILARITY":1,"SEQUENCE CAUTION":3},"countByFeatureType":{"Propeptide":2,"Chain":2,"Domain":1,"Region":2,"Active site":2,"Site":1,"Modified residue":3,"Alternative sequence":7,"Natural variant":3,"Mutagenesis":14,"Helix":16,"Beta strand":14,"Turn":4,"Initiator methionine":1},"uniParcId":"UPI000003AEFA"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"H0YD34","uniProtkbId":"H0YD34_HUMAN","entryAudit":{"firstPublicDate":"2012-02-22","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2012-02-22","entryVersion":78,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000432879.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000432879.1"}],"value":"Caspase 4"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000432879.1"}],"value":"CASP4"}}],"features":[{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":37,"modifier":"EXACT"}},"description":"Caspase family p10","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50207"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000432879.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":72,"modifier":"EXACT"},"end":{"value":72,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000432879.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"H0YD34"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"H0YD34"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000432879.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000432879.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16554811","citationType":"journal article","authors":["Taylor T.D.","Noguchi H.","Totoki Y.","Toyoda A.","Kuroki Y.","Dewar K.","Lloyd C.","Itoh T.","Takeda T.","Kim D.W.","She X.","Barlow K.F.","Bloom T.","Bruford E.","Chang J.L.","Cuomo C.A.","Eichler E.","FitzGerald M.G.","Jaffe D.B.","LaButti K.","Nicol R.","Park H.S.","Seaman C.","Sougnez C.","Yang X.","Zimmer A.R.","Zody M.C.","Birren B.W.","Nusbaum C.","Fujiyama A.","Hattori M.","Rogers J.","Lander E.S.","Sakaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"16554811"},{"database":"DOI","id":"10.1038/nature04632"}],"title":"Human chromosome 11 DNA sequence and analysis including novel gene identification.","publicationDate":"2006","journal":"Nature","firstPage":"497","lastPage":"500","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000432879.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000432879.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AP001153","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AP002004","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"MassIVE","id":"H0YD34","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"37265","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"18094","properties":[{"key":"antibodies","value":"744 antibodies from 44 providers"}]},{"database":"Ensembl","id":"ENST00000533252.1","properties":[{"key":"ProteinId","value":"ENSP00000432879.1"},{"key":"GeneId","value":"ENSG00000196954.14"}]},{"database":"UCSC","id":"uc058gxl.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:1505","properties":[{"key":"GeneName","value":"CASP4"}]},{"database":"OpenTargets","id":"ENSG00000196954","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000196954","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000161497","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_2746578_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"6097640at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"CASP4","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 11"}]},{"database":"Bgee","id":"ENSG00000196954","properties":[{"key":"ExpressionPatterns","value":"Expressed in monocyte and 178 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"H0YD34","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0004197","properties":[{"key":"GoTerm","value":"F:cysteine-type endopeptidase activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006508","properties":[{"key":"GoTerm","value":"P:proteolysis"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"3.30.70.1470","properties":[{"key":"EntryName","value":"Caspase-like"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR029030","properties":[{"key":"EntryName","value":"Caspase-like_dom_sf"}]},{"database":"InterPro","id":"IPR002398","properties":[{"key":"EntryName","value":"Pept_C14"}]},{"database":"InterPro","id":"IPR011600","properties":[{"key":"EntryName","value":"Pept_C14_caspase"}]},{"database":"InterPro","id":"IPR002138","properties":[{"key":"EntryName","value":"Pept_C14_p10"}]},{"database":"PANTHER","id":"PTHR47901","properties":[{"key":"EntryName","value":"CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 18"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR47901:SF3","properties":[{"key":"EntryName","value":"CASPASE-1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00656","properties":[{"key":"EntryName","value":"Peptidase_C14"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52129","properties":[{"key":"EntryName","value":"Caspase-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50207","properties":[{"key":"EntryName","value":"CASPASE_P10"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"XNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKEATSSPALLNQLQGAPSLVQLAYLTFCISIKVKTN","length":72,"molWeight":8172,"crc64":"D8935A975E94C726","md5":"F5799CAC008D9A4D1E5A5705EAAC76FD"},"extraAttributes":{"countByFeatureType":{"Domain":1,"Non-terminal residue":2},"uniParcId":"UPI0001F78738"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"E9PMT1","uniProtkbId":"E9PMT1_HUMAN","entryAudit":{"firstPublicDate":"2011-04-05","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-04-05","entryVersion":100,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000401673.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000401673.2"}],"value":"Caspase 4"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000401673.2"}],"value":"CASP4"}}],"features":[{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":81,"modifier":"EXACT"}},"description":"CARD","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50209"}]},{"type":"Region","location":{"start":{"value":83,"modifier":"EXACT"},"end":{"value":104,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":147,"modifier":"EXACT"},"end":{"value":147,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000401673.2"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"E9PMT1"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"E9PMT1"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000401673.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000401673.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16554811","citationType":"journal article","authors":["Taylor T.D.","Noguchi H.","Totoki Y.","Toyoda A.","Kuroki Y.","Dewar K.","Lloyd C.","Itoh T.","Takeda T.","Kim D.W.","She X.","Barlow K.F.","Bloom T.","Bruford E.","Chang J.L.","Cuomo C.A.","Eichler E.","FitzGerald M.G.","Jaffe D.B.","LaButti K.","Nicol R.","Park H.S.","Seaman C.","Sougnez C.","Yang X.","Zimmer A.R.","Zody M.C.","Birren B.W.","Nusbaum C.","Fujiyama A.","Hattori M.","Rogers J.","Lander E.S.","Sakaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"16554811"},{"database":"DOI","id":"10.1038/nature04632"}],"title":"Human chromosome 11 DNA sequence and analysis including novel gene identification.","publicationDate":"2006","journal":"Nature","firstPage":"497","lastPage":"500","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000401673.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"18669648","citationType":"journal article","authors":["Dephoure N.","Zhou C.","Villen J.","Beausoleil S.A.","Bakalarski C.E.","Elledge S.J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"18669648"},{"database":"DOI","id":"10.1073/pnas.0805139105"}],"title":"A quantitative atlas of mitotic phosphorylation.","publicationDate":"2008","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10762","lastPage":"10767","volume":"105"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"18669648"}]},{"referenceNumber":5,"citation":{"id":"20068231","citationType":"journal article","authors":["Olsen J.V.","Vermeulen M.","Santamaria A.","Kumar C.","Miller M.L.","Jensen L.J.","Gnad F.","Cox J.","Jensen T.S.","Nigg E.A.","Brunak S.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"20068231"},{"database":"DOI","id":"10.1126/scisignal.2000475"}],"title":"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.","publicationDate":"2010","journal":"Sci. Signal.","firstPage":"RA3","lastPage":"RA3","volume":"3"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"20068231"}]},{"referenceNumber":6,"citation":{"id":"22814378","citationType":"journal article","authors":["Van Damme P.","Lasa M.","Polevoda B.","Gazquez C.","Elosegui-Artola A.","Kim D.S.","De Juan-Pardo E.","Demeyer K.","Hole K.","Larrea E.","Timmerman E.","Prieto J.","Arnesen T.","Sherman F.","Gevaert K.","Aldabe R."],"citationCrossReferences":[{"database":"PubMed","id":"22814378"},{"database":"DOI","id":"10.1073/pnas.1210303109"}],"title":"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.","publicationDate":"2012","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"12449","lastPage":"12454","volume":"109"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"22814378"}]},{"referenceNumber":7,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000401673.2"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AP001153","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AP002004","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"E9PMT1","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"E9PMT1","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"E9PMT1","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"22205","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"18094","properties":[{"key":"antibodies","value":"744 antibodies from 44 providers"}]},{"database":"Ensembl","id":"ENST00000417440.2","properties":[{"key":"ProteinId","value":"ENSP00000401673.2"},{"key":"GeneId","value":"ENSG00000196954.14"}]},{"database":"UCSC","id":"uc058gxt.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:1505","properties":[{"key":"GeneName","value":"CASP4"}]},{"database":"OpenTargets","id":"ENSG00000196954","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000196954","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000161497","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_1772300_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"ACRGANH","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"6097640at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"CASP4","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 11"}]},{"database":"Bgee","id":"ENSG00000196954","properties":[{"key":"ExpressionPatterns","value":"Expressed in monocyte and 178 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"E9PMT1","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0004197","properties":[{"key":"GoTerm","value":"F:cysteine-type endopeptidase activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006508","properties":[{"key":"GoTerm","value":"P:proteolysis"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0042981","properties":[{"key":"GoTerm","value":"P:regulation of apoptotic process"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd08325","properties":[{"key":"EntryName","value":"CARD_CASP1-like"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.533.10:FF:000073","properties":[{"key":"EntryName","value":"Inactive caspase-12"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.1460","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.533.10","properties":[{"key":"EntryName","value":"Death Domain, Fas"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001315","properties":[{"key":"EntryName","value":"CARD"}]},{"database":"InterPro","id":"IPR029030","properties":[{"key":"EntryName","value":"Caspase-like_dom_sf"}]},{"database":"InterPro","id":"IPR011029","properties":[{"key":"EntryName","value":"DEATH-like_dom_sf"}]},{"database":"InterPro","id":"IPR002398","properties":[{"key":"EntryName","value":"Pept_C14"}]},{"database":"PANTHER","id":"PTHR47901","properties":[{"key":"EntryName","value":"CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 18"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR47901:SF3","properties":[{"key":"EntryName","value":"CASPASE-1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00619","properties":[{"key":"EntryName","value":"CARD"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00114","properties":[{"key":"EntryName","value":"CARD"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52129","properties":[{"key":"EntryName","value":"Caspase-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF47986","properties":[{"key":"EntryName","value":"DEATH domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50209","properties":[{"key":"EntryName","value":"CARD"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAEGNHRKKPLKVLESLGKDFLTGVLDNLVEQNVLNWKEEEKKKYYDAKTEDKVRVMADSMQEKQRMAGQMLLQTFFNIDQISPNKKAHPNMEAGPPESGESTDALKLCPHEEFLRLCKERAEEIYPIKERNNRTRLALIICNTEFD","length":147,"molWeight":17068,"crc64":"799F62916DDC83E3","md5":"5797BDC799370D1A68418D21CC6884DF"},"extraAttributes":{"countByFeatureType":{"Domain":1,"Region":1,"Non-terminal residue":1},"uniParcId":"UPI0001F78739"}}]}