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It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P35564"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P35565"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16361248"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20801878"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21205830"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22314232"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23826168"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29765154"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31735293"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32783947"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34338405"}],"value":"Interacts with MAPK3/ERK1 (By similarity). Interacts with KCNH2 (PubMed:16361248). Associates with ribosomes (By similarity). Interacts with SGIP1; involved in negative regulation of endocytosis (By similarity). The palmitoylated form interacts with the ribosome-translocon complex component SSR1, promoting efficient folding of glycoproteins (PubMed:22314232). Interacts with SERPINA2P/SERPINA2 and with the S and Z variants of SERPINA1 (PubMed:23826168). Interacts with PPIB (PubMed:20801878). Interacts with ZNRF4 (PubMed:21205830). Interacts with SMIM22 (PubMed:29765154). Interacts with TMX2 (PubMed:31735293). Interacts with TMEM35A/NACHO (By similarity). Interacts with CHRNA7 (PubMed:32783947). Interacts with reticulophagy regulators RETREG2 and RETREG3 (PubMed:34338405). Interacts with DNM1L; may form part of a larger protein complex at the ER-mitochondrial interface during mitochondrial fission (PubMed:24196833). 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