{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9HB71","secondaryAccessions":["B2ZWH2","B3KSF1","O60666","Q5R370","Q5R371"],"uniProtkbId":"CYBP_HUMAN","entryAudit":{"firstPublicDate":"2004-04-26","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2004-04-26","entryVersion":207,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Calcyclin-binding protein"},"shortNames":[{"value":"CacyBP"},{"value":"hCacyBP"}]},"alternativeNames":[{"fullName":{"value":"S100A6-binding protein"}},{"fullName":{"value":"Siah-interacting protein"}}]},"genes":[{"geneName":{"value":"CACYBP"},"synonyms":[{"value":"S100A6BP"},{"value":"SIP"}],"orfNames":[{"value":"PNAS-107"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16085652"}],"value":"May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11389839"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16085652"}],"value":"Homodimer. Interacts with proteins of the S100 family S100A1, S100A6, S100B, S100P and S100A12 in a calcium-dependent manner (By similarity). Component of some large E3 complex at least composed of UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC and TBL1X. Interacts directly with SIAH1, SIAH2 and SKP1"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q9HB71","intActId":"EBI-1047302"},"interactantTwo":{"uniProtKBAccession":"Q02410","geneName":"APBA1","intActId":"EBI-368690"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9HB71","intActId":"EBI-1047302"},"interactantTwo":{"uniProtKBAccession":"Q99767","geneName":"APBA2","intActId":"EBI-81711"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9HB71","intActId":"EBI-1047302"},"interactantTwo":{"uniProtKBAccession":"Q12959","geneName":"DLG1","intActId":"EBI-357481"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9HB71","intActId":"EBI-1047302"},"interactantTwo":{"uniProtKBAccession":"Q15700","geneName":"DLG2","intActId":"EBI-80426"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9HB71","intActId":"EBI-1047302"},"interactantTwo":{"uniProtKBAccession":"Q92796","geneName":"DLG3","intActId":"EBI-80440"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9HB71","intActId":"EBI-1047302"},"interactantTwo":{"uniProtKBAccession":"P78352","geneName":"DLG4","intActId":"EBI-80389"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9HB71","intActId":"EBI-1047302"},"interactantTwo":{"uniProtKBAccession":"P04626","geneName":"ERBB2","intActId":"EBI-641062"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9HB71","intActId":"EBI-1047302"},"interactantTwo":{"uniProtKBAccession":"Q68DX3","geneName":"FRMPD2","intActId":"EBI-53993476"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9HB71","intActId":"EBI-1047302"},"interactantTwo":{"uniProtKBAccession":"A4D2P6","geneName":"GRID2IP","intActId":"EBI-15893226"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9HB71","intActId":"EBI-1047302"},"interactantTwo":{"uniProtKBAccession":"Q9Y3R0","geneName":"GRIP1","intActId":"EBI-5349621"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9HB71","intActId":"EBI-1047302"},"interactantTwo":{"uniProtKBAccession":"Q9C0E4","geneName":"GRIP2","intActId":"EBI-949557"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9HB71","intActId":"EBI-1047302"},"interactantTwo":{"uniProtKBAccession":"Q14005","geneName":"IL16","intActId":"EBI-2831580"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9HB71","intActId":"EBI-1047302"},"interactantTwo":{"uniProtKBAccession":"Q8TBB1","geneName":"LNX1","intActId":"EBI-739832"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9HB71","intActId":"EBI-1047302"},"interactantTwo":{"uniProtKBAccession":"Q8N448","geneName":"LNX2","intActId":"EBI-2340947"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9HB71","intActId":"EBI-1047302"},"interactantTwo":{"uniProtKBAccession":"Q96QZ7","geneName":"MAGI1","intActId":"EBI-924464"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9HB71","intActId":"EBI-1047302"},"interactantTwo":{"uniProtKBAccession":"Q86UL8","geneName":"MAGI2","intActId":"EBI-311035"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9HB71","intActId":"EBI-1047302"},"interactantTwo":{"uniProtKBAccession":"O75970","geneName":"MPDZ","intActId":"EBI-821405"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9HB71","intActId":"EBI-1047302"},"interactantTwo":{"uniProtKBAccession":"Q86UT5","geneName":"NHERF4","intActId":"EBI-8744528"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9HB71","intActId":"EBI-1047302"},"interactantTwo":{"uniProtKBAccession":"Q8NI35","geneName":"PATJ","intActId":"EBI-724390"},"numberOfExperiments":9,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9HB71","intActId":"EBI-1047302"},"interactantTwo":{"uniProtKBAccession":"Q5T2W1","geneName":"PDZK1","intActId":"EBI-349819"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9HB71","intActId":"EBI-1047302"},"interactantTwo":{"uniProtKBAccession":"P26447","geneName":"S100A4","intActId":"EBI-717058"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9HB71","intActId":"EBI-1047302"},"interactantTwo":{"uniProtKBAccession":"P33763","geneName":"S100A5","intActId":"EBI-7211732"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9HB71","intActId":"EBI-1047302"},"interactantTwo":{"uniProtKBAccession":"P06703","geneName":"S100A6","intActId":"EBI-352877"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9HB71","intActId":"EBI-1047302"},"interactantTwo":{"uniProtKBAccession":"Q14160","geneName":"SCRIB","intActId":"EBI-357345"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9HB71","intActId":"EBI-1047302"},"interactantTwo":{"uniProtKBAccession":"Q07157","geneName":"TJP1","intActId":"EBI-79553"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9HB71","intActId":"EBI-1047302"},"interactantTwo":{"uniProtKBAccession":"Q9P202","geneName":"WHRN","intActId":"EBI-310886"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"value":"Cytoplasmic at low calcium concentrations. In neuroblastoma cells, after a retinoic acid (RA) induction and calcium increase, it localizes in both the nucleus and cytoplasm. The nuclear fraction may be phosphorylated"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12895292"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12895292"}],"value":"Cytoplasm","id":"SL-0086"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q9HB71-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"synonyms":[{"value":"SIP-S"},{"value":"S"}],"isoformIds":["Q9HB71-2"],"sequenceIds":["VSP_010171","VSP_010172"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"isoformIds":["Q9HB71-3"],"sequenceIds":["VSP_046862"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12895292"}],"value":"Phosphorylated on serine residues. Phosphorylated upon induction by RA or at high calcium concentrations"}],"commentType":"PTM"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Frameshift","sequence":"AAG23817.1","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Frameshift","sequence":"BAG52713.1","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Initiator methionine","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"Removed","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37316325"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.10"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.11"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19413330"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"22223895"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"22814378"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"25944712"}]},{"type":"Chain","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":228,"modifier":"EXACT"}},"description":"Calcyclin-binding protein","featureId":"PRO_0000185389"},{"type":"Domain","location":{"start":{"value":73,"modifier":"EXACT"},"end":{"value":167,"modifier":"EXACT"}},"description":"CS","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00547"}]},{"type":"Domain","location":{"start":{"value":168,"modifier":"EXACT"},"end":{"value":228,"modifier":"EXACT"}},"description":"SGS","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00386"}]},{"type":"Region","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":80,"modifier":"EXACT"}},"description":"Interaction with SIAH1"},{"type":"Region","location":{"start":{"value":73,"modifier":"EXACT"},"end":{"value":228,"modifier":"EXACT"}},"description":"Interaction with SKP1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11389839"}]},{"type":"Region","location":{"start":{"value":154,"modifier":"EXACT"},"end":{"value":228,"modifier":"EXACT"}},"description":"Interaction with S100A6","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Modified residue","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":2,"modifier":"EXACT"}},"description":"N-acetylalanine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37316325"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.10"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.11"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19413330"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"22223895"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"22814378"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"25944712"}]},{"type":"Modified residue","location":{"start":{"value":3,"modifier":"EXACT"},"end":{"value":3,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":8,"modifier":"EXACT"},"end":{"value":8,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19608861"}]},{"type":"Modified residue","location":{"start":{"value":19,"modifier":"EXACT"},"end":{"value":19,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19608861"}]},{"type":"Modified residue","location":{"start":{"value":34,"modifier":"EXACT"},"end":{"value":34,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":85,"modifier":"EXACT"},"end":{"value":85,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19608861"}]},{"type":"Modified residue","location":{"start":{"value":118,"modifier":"EXACT"},"end":{"value":118,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19608861"}]},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":43,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"}],"featureId":"VSP_046862","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":73,"modifier":"EXACT"},"end":{"value":80,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000305"}],"featureId":"VSP_010171","alternativeSequence":{"originalSequence":"VKISNYGW","alternativeSequences":["DGISQISL"]}},{"type":"Alternative sequence","location":{"start":{"value":81,"modifier":"EXACT"},"end":{"value":228,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000305"}],"featureId":"VSP_010172","alternativeSequence":{}},{"type":"Mutagenesis","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":26,"modifier":"EXACT"}},"description":"Abolishes interaction with SIAH1.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16085652"}],"alternativeSequence":{"originalSequence":"KRVR","alternativeSequences":["AAVA"]}},{"type":"Mutagenesis","location":{"start":{"value":64,"modifier":"EXACT"},"end":{"value":64,"modifier":"EXACT"}},"description":"Abolishes interaction with SIAH1; when associated with N-66.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16085652"}],"alternativeSequence":{"originalSequence":"V","alternativeSequences":["N"]}},{"type":"Mutagenesis","location":{"start":{"value":66,"modifier":"EXACT"},"end":{"value":66,"modifier":"EXACT"}},"description":"Abolishes interaction with SIAH1; when associated with N-64.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16085652"}],"alternativeSequence":{"originalSequence":"P","alternativeSequences":["N"]}},{"type":"Sequence conflict","location":{"start":{"value":44,"modifier":"EXACT"},"end":{"value":44,"modifier":"EXACT"}},"description":"in Ref. 4; AAG23817","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"M","alternativeSequences":["V"]}},{"type":"Sequence conflict","location":{"start":{"value":177,"modifier":"EXACT"},"end":{"value":177,"modifier":"EXACT"}},"description":"in Ref. 4; AAG23817","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["K"]}},{"type":"Sequence conflict","location":{"start":{"value":183,"modifier":"EXACT"},"end":{"value":183,"modifier":"EXACT"}},"description":"in Ref. 4; AAG23817","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"T","alternativeSequences":["P"]}},{"type":"Sequence conflict","location":{"start":{"value":226,"modifier":"EXACT"},"end":{"value":226,"modifier":"EXACT"}},"description":"in Ref. 4; AAG23817","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"T","alternativeSequences":["P"]}},{"type":"Helix","location":{"start":{"value":3,"modifier":"EXACT"},"end":{"value":19,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2A26"}]},{"type":"Helix","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":46,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2A26"}]},{"type":"Beta strand","location":{"start":{"value":61,"modifier":"EXACT"},"end":{"value":64,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2A25"}]},{"type":"Beta strand","location":{"start":{"value":79,"modifier":"EXACT"},"end":{"value":83,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1X5M"}]},{"type":"Beta strand","location":{"start":{"value":86,"modifier":"EXACT"},"end":{"value":92,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1X5M"}]},{"type":"Turn","location":{"start":{"value":94,"modifier":"EXACT"},"end":{"value":98,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1X5M"}]},{"type":"Beta strand","location":{"start":{"value":103,"modifier":"EXACT"},"end":{"value":108,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1X5M"}]},{"type":"Beta strand","location":{"start":{"value":110,"modifier":"EXACT"},"end":{"value":117,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1X5M"}]},{"type":"Beta strand","location":{"start":{"value":121,"modifier":"EXACT"},"end":{"value":123,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1X5M"}]},{"type":"Beta strand","location":{"start":{"value":125,"modifier":"EXACT"},"end":{"value":130,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1X5M"}]},{"type":"Beta strand","location":{"start":{"value":132,"modifier":"EXACT"},"end":{"value":134,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1X5M"}]},{"type":"Turn","location":{"start":{"value":138,"modifier":"EXACT"},"end":{"value":140,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1X5M"}]},{"type":"Beta strand","location":{"start":{"value":142,"modifier":"EXACT"},"end":{"value":146,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1X5M"}]},{"type":"Beta strand","location":{"start":{"value":149,"modifier":"EXACT"},"end":{"value":155,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1X5M"}]},{"type":"Beta strand","location":{"start":{"value":157,"modifier":"EXACT"},"end":{"value":160,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1X5M"}]},{"type":"Beta strand","location":{"start":{"value":164,"modifier":"EXACT"},"end":{"value":167,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1X5M"}]},{"type":"Helix","location":{"start":{"value":168,"modifier":"EXACT"},"end":{"value":174,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1X5M"}]},{"type":"Modified residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"},"sequence":"Q9HB71-3"},"description":"N-acetylmethionine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37316325"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0007","category":"PTM","name":"Acetylation"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0903","category":"Technical term","name":"Direct protein sequencing"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0833","category":"Biological process","name":"Ubl conjugation pathway"}],"references":[{"referenceNumber":1,"citation":{"id":"12006993","citationType":"journal article","authors":["Liu W.X.","Wu J.","Zhao Z.","Zhou Y.","Peng X.Z.","Yuan J.G.","Qiang B.Q."],"citationCrossReferences":[{"database":"PubMed","id":"12006993"}],"title":"Cloning and expression of human calcyclin binding protein (hCacyBP) gene.","publicationDate":"2002","journal":"Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao","firstPage":"181","lastPage":"186","volume":"34"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"CI-AN9317ABI6N12","citationType":"submission","authors":["Petersen S.","Schluens K.","Dietel M.","Petersen I."],"title":"Amplification and overexpression of the gene encoding the human calcyclin binding protein on chromosome 1q24-q25 in advanced lung carcinomas.","publicationDate":"OCT-2000","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)"]},{"referenceNumber":3,"citation":{"id":"CI-3R5VM9LC8T1NH","citationType":"submission","authors":["Rhodes S."],"publicationDate":"JAN-1999","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"]},{"referenceNumber":4,"citation":{"id":"CI-AKUCFGHPFEQMJ","citationType":"submission","authors":["Yu W.-Q.","Sun B.-Z.","Chai Y.-B.","Zhu F.","Liu X.-S.","Li Z.","Lu F.","Yan W.","Yang H.","Zhao Z.-L."],"title":"Human acute promyelocytic leukemia cell line NB4's apoptosis related genes.","publicationDate":"JUN-2000","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Promyelocytic leukemia","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"CI-231EAFROMQN9I","citationType":"submission","authors":["Kim J.W."],"title":"Identification of a human growth inhibition gene 5 (GIG5).","publicationDate":"SEP-2003","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"]},{"referenceNumber":6,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3)"],"referenceComments":[{"value":"Skeletal muscle","type":"TISSUE"},{"value":"Testis","type":"TISSUE"}]},{"referenceNumber":7,"citation":{"id":"16710414","citationType":"journal article","authors":["Gregory S.G.","Barlow K.F.","McLay K.E.","Kaul R.","Swarbreck D.","Dunham A.","Scott C.E.","Howe K.L.","Woodfine K.","Spencer C.C.A.","Jones M.C.","Gillson C.","Searle S.","Zhou Y.","Kokocinski F.","McDonald L.","Evans R.","Phillips K.","Atkinson A.","Cooper R.","Jones C.","Hall R.E.","Andrews T.D.","Lloyd C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Anderson F.","Andrew R.W.","Ashwell R.I.S.","Aubin K.","Babbage A.K.","Bagguley C.L.","Bailey J.","Beasley H.","Bethel G.","Bird C.P.","Bray-Allen S.","Brown J.Y.","Brown A.J.","Buckley D.","Burton J.","Bye J.","Carder C.","Chapman J.C.","Clark S.Y.","Clarke G.","Clee C.","Cobley V.","Collier R.E.","Corby N.","Coville G.J.","Davies J.","Deadman R.","Dunn M.","Earthrowl M.","Ellington A.G.","Errington H.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Gay L.","Ghori M.R.J.","Gibson R.","Gilby L.M.","Gillett W.","Glithero R.J.","Grafham D.V.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Hammond S.","Harrison E.S.I.","Hart E.","Haugen E.","Heath P.D.","Holmes S.","Holt K.","Howden P.J.","Hunt A.R.","Hunt S.E.","Hunter G.","Isherwood J.","James R.","Johnson C.","Johnson D.","Joy A.","Kay M.","Kershaw J.K.","Kibukawa M.","Kimberley A.M.","King A.","Knights A.J.","Lad H.","Laird G.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Loveland J.","Lovell J.","Lush M.J.","Lyne R.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","Matthews N.S.W.","McLaren S.","Milne S.","Mistry S.","Moore M.J.F.","Nickerson T.","O'Dell C.N.","Oliver K.","Palmeiri A.","Palmer S.A.","Parker A.","Patel D.","Pearce A.V.","Peck A.I.","Pelan S.","Phelps K.","Phillimore B.J.","Plumb R.","Rajan J.","Raymond C.","Rouse G.","Saenphimmachak C.","Sehra H.K.","Sheridan E.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.","Steward C.","Subramanian S.","Sycamore N.","Tracey A.","Tromans A.","Van Helmond Z.","Wall M.","Wallis J.M.","White S.","Whitehead S.L.","Wilkinson J.E.","Willey D.L.","Williams H.","Wilming L.","Wray P.W.","Wu Z.","Coulson A.","Vaudin M.","Sulston J.E.","Durbin R.M.","Hubbard T.","Wooster R.","Dunham I.","Carter N.P.","McVean G.","Ross M.T.","Harrow J.","Olson M.V.","Beck S.","Rogers J.","Bentley D.R."],"citationCrossReferences":[{"database":"PubMed","id":"16710414"},{"database":"DOI","id":"10.1038/nature04727"}],"title":"The DNA sequence and biological annotation of human chromosome 1.","publicationDate":"2006","journal":"Nature","firstPage":"315","lastPage":"321","volume":"441"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":8,"citation":{"id":"CI-56FT96O07V0QG","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"JUL-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":9,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"Brain","type":"TISSUE"},{"value":"Skin","type":"TISSUE"}]},{"referenceNumber":10,"citation":{"id":"CI-8VKQN6BT2S0NP","citationType":"submission","authors":["Bienvenut W.V.","Boldt K.","von Kriegsheim A.F.","Kolch W."],"publicationDate":"JUL-2007","submissionDatabase":"UniProtKB"},"referencePositions":["PROTEIN SEQUENCE OF 2-14; 34-41; 112-118 AND 124-143","CLEAVAGE OF INITIATOR METHIONINE","ACETYLATION AT ALA-2","IDENTIFICATION BY MASS SPECTROMETRY"],"referenceComments":[{"value":"Hepatoma","type":"TISSUE"}]},{"referenceNumber":11,"citation":{"id":"CI-JUHP91IUVCP9","citationType":"submission","authors":["Bienvenut W.V.","Heiserich L.","Gottlieb E."],"publicationDate":"MAR-2008","submissionDatabase":"UniProtKB"},"referencePositions":["PROTEIN SEQUENCE OF 2-19 AND 112-118","CLEAVAGE OF INITIATOR METHIONINE","ACETYLATION AT ALA-2","IDENTIFICATION BY MASS SPECTROMETRY"],"referenceComments":[{"value":"Colon carcinoma","type":"TISSUE"}]},{"referenceNumber":12,"citation":{"id":"11389839","citationType":"journal article","authors":["Matsuzawa S.","Reed J.C."],"citationCrossReferences":[{"database":"PubMed","id":"11389839"},{"database":"DOI","id":"10.1016/s1097-2765(01)00242-8"}],"title":"Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses.","publicationDate":"2001","journal":"Mol. Cell","firstPage":"915","lastPage":"926","volume":"7"},"referencePositions":["ALTERNATIVE SPLICING (ISOFORM 2)","SUBUNIT OF A COMPLEX WITH UBE2D1; SIAH1; SKP1; APC AND TBL1X","INTERACTION WITH SIAH1; SIAH2 AND SKP1"]},{"referenceNumber":13,"citation":{"id":"12895292","citationType":"journal article","authors":["Wu J.","Tan X.","Peng X.Z.","Yuan J.G.","Qiang B.Q."],"citationCrossReferences":[{"database":"PubMed","id":"12895292"},{"database":"DOI","id":"10.5483/bmbrep.2003.36.4.354"}],"title":"Translocation and phosphorylation of calcyclin binding protein during retinoic acid-induced neuronal differentiation of neuroblastoma SH-SY5Y cells.","publicationDate":"2003","journal":"J. Biochem. Mol. Biol.","firstPage":"354","lastPage":"358","volume":"36"},"referencePositions":["SUBCELLULAR LOCATION","PHOSPHORYLATION"]},{"referenceNumber":14,"citation":{"id":"19413330","citationType":"journal article","authors":["Gauci S.","Helbig A.O.","Slijper M.","Krijgsveld J.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"19413330"},{"database":"DOI","id":"10.1021/ac9004309"}],"title":"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.","publicationDate":"2009","journal":"Anal. Chem.","firstPage":"4493","lastPage":"4501","volume":"81"},"referencePositions":["ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2","CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":15,"citation":{"id":"19690332","citationType":"journal article","authors":["Mayya V.","Lundgren D.H.","Hwang S.-I.","Rezaul K.","Wu L.","Eng J.K.","Rodionov V.","Han D.K."],"citationCrossReferences":[{"database":"PubMed","id":"19690332"},{"database":"DOI","id":"10.1126/scisignal.2000007"}],"title":"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.","publicationDate":"2009","journal":"Sci. Signal.","firstPage":"RA46","lastPage":"RA46","volume":"2"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Leukemic T-cell","type":"TISSUE"}]},{"referenceNumber":16,"citation":{"id":"19608861","citationType":"journal article","authors":["Choudhary C.","Kumar C.","Gnad F.","Nielsen M.L.","Rehman M.","Walther T.C.","Olsen J.V.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"19608861"},{"database":"DOI","id":"10.1126/science.1175371"}],"title":"Lysine acetylation targets protein complexes and co-regulates major cellular functions.","publicationDate":"2009","journal":"Science","firstPage":"834","lastPage":"840","volume":"325"},"referencePositions":["ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-8; LYS-19; LYS-85 AND LYS-118","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":17,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Buerckstuemmer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":18,"citation":{"id":"22223895","citationType":"journal article","authors":["Bienvenut W.V.","Sumpton D.","Martinez A.","Lilla S.","Espagne C.","Meinnel T.","Giglione C."],"citationCrossReferences":[{"database":"PubMed","id":"22223895"},{"database":"DOI","id":"10.1074/mcp.m111.015131"}],"title":"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.","publicationDate":"2012","journal":"Mol. Cell. Proteomics","firstPage":"M111.015131","lastPage":"M111.015131","volume":"11"},"referencePositions":["ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2","CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":19,"citation":{"id":"22814378","citationType":"journal article","authors":["Van Damme P.","Lasa M.","Polevoda B.","Gazquez C.","Elosegui-Artola A.","Kim D.S.","De Juan-Pardo E.","Demeyer K.","Hole K.","Larrea E.","Timmerman E.","Prieto J.","Arnesen T.","Sherman F.","Gevaert K.","Aldabe R."],"citationCrossReferences":[{"database":"PubMed","id":"22814378"},{"database":"DOI","id":"10.1073/pnas.1210303109"}],"title":"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.","publicationDate":"2012","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"12449","lastPage":"12454","volume":"109"},"referencePositions":["ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2","CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":20,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"},{"database":"DOI","id":"10.1021/pr300630k"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3 AND SER-34","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"},{"value":"Erythroleukemia","type":"TISSUE"}]},{"referenceNumber":21,"citation":{"id":"25944712","citationType":"journal article","authors":["Vaca Jacome A.S.","Rabilloud T.","Schaeffer-Reiss C.","Rompais M.","Ayoub D.","Lane L.","Bairoch A.","Van Dorsselaer A.","Carapito C."],"citationCrossReferences":[{"database":"PubMed","id":"25944712"},{"database":"DOI","id":"10.1002/pmic.201400617"}],"title":"N-terminome analysis of the human mitochondrial proteome.","publicationDate":"2015","journal":"Proteomics","firstPage":"2519","lastPage":"2524","volume":"15"},"referencePositions":["ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2","CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":22,"citation":{"id":"37316325","citationType":"journal article","authors":["Bogaert A.","Fijalkowska D.","Staes A.","Van de Steene T.","Vuylsteke M.","Stadler C.","Eyckerman S.","Spirohn K.","Hao T.","Calderwood M.A.","Gevaert K."],"citationCrossReferences":[{"database":"PubMed","id":"37316325"},{"database":"DOI","id":"10.26508/lsa.202301972"}],"title":"N-terminal proteoforms may engage in different protein complexes.","publicationDate":"2023","journal":"Life. Sci Alliance","firstPage":"0","lastPage":"0","volume":"6"},"referencePositions":["CLEAVAGE OF INITIATOR METHIONINE (ISOFORM 1)","ACETYLATION AT ALA-2 (ISOFORM 1)","ACETYLATION AT MET-1 (ISOFORM 3)"]},{"referenceNumber":23,"citation":{"id":"16085652","citationType":"journal article","authors":["Santelli E.","Leone M.","Li C.","Fukushima T.","Preece N.E.","Olson A.J.","Ely K.R.","Reed J.C.","Pellecchia M.","Liddington R.C.","Matsuzawa S."],"citationCrossReferences":[{"database":"PubMed","id":"16085652"},{"database":"DOI","id":"10.1074/jbc.m506707200"}],"title":"Structural analysis of Siah1-Siah-interacting protein interactions and insights into the assembly of an E3 ligase multiprotein complex.","publicationDate":"2005","journal":"J. Biol. Chem.","firstPage":"34278","lastPage":"34287","volume":"280"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.2 ANGSTROMS) OF 1-70","SUBUNIT","MUTAGENESIS OF 23-LYS--ARG-26; VAL-64 AND PRO-66","FUNCTION","INTERACTION WITH SIAH1"]},{"referenceNumber":24,"citation":{"id":"CI-7IH4UQ2I8B2E3","citationType":"submission","authoringGroup":["RIKEN structural genomics initiative (RSGI)"],"title":"Solution structure of the core domain of calcyclin binding protein; SIAH-interacting protein (SIP).","publicationDate":"NOV-2005","submissionDatabase":"PDB data bank"},"referencePositions":["STRUCTURE BY NMR OF 63-176"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AF057356","properties":[{"key":"ProteinId","value":"AAC21458.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF314752","properties":[{"key":"ProteinId","value":"AAG34170.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AL035305","properties":[{"key":"ProteinId","value":"CAA22910.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF275803","properties":[{"key":"ProteinId","value":"AAG23817.1"},{"key":"Status","value":"ALT_FRAME"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AY423723","properties":[{"key":"ProteinId","value":"AAS00486.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK093425","properties":[{"key":"ProteinId","value":"BAG52713.1"},{"key":"Status","value":"ALT_FRAME"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK313278","properties":[{"key":"ProteinId","value":"BAG36086.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"Z99127","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471067","properties":[{"key":"ProteinId","value":"EAW90982.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC005975","properties":[{"key":"ProteinId","value":"AAH05975.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC022352","properties":[{"key":"ProteinId","value":"AAH22352.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC078151","properties":[{"key":"ProteinId","value":"AAH78151.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS1315.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9HB71-1"},{"database":"CCDS","id":"CCDS30942.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9HB71-3"},{"database":"RefSeq","id":"NP_001007215.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001007214.1"}],"isoformId":"Q9HB71-3"},{"database":"RefSeq","id":"NP_055227.1","properties":[{"key":"NucleotideSequenceId","value":"NM_014412.3"}],"isoformId":"Q9HB71-1"},{"database":"PDB","id":"1X5M","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=63-176"}]},{"database":"PDB","id":"2A25","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.20 A"},{"key":"Chains","value":"B=58-70"}]},{"database":"PDB","id":"2A26","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.20 A"},{"key":"Chains","value":"A/B/C=1-47"}]},{"database":"PDBsum","id":"1X5M","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2A25","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2A26","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"Q9HB71","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q9HB71","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"118001","properties":[{"key":"Interactions","value":"299"}]},{"database":"CORUM","id":"Q9HB71","properties":[{"key":"Description","value":"-"}]},{"database":"ELM","id":"Q9HB71","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q9HB71","properties":[{"key":"Number of interactors","value":"2964"}]},{"database":"IntAct","id":"Q9HB71","properties":[{"key":"Interactions","value":"399"}]},{"database":"MINT","id":"Q9HB71","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-CACYBP","properties":[{"key":"Evidences","value":"1 NDEx IQuery Curated Pathway"}]},{"database":"STRING","id":"9606.ENSP00000356652","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"Q9HB71","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL4295948","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"Q9HB71","properties":[{"key":"glycosylation","value":"1 site, 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"Q9HB71","properties":[{"key":"Description","value":"-"}]},{"database":"MetOSite","id":"Q9HB71","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q9HB71","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"Q9HB71","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"CACYBP","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"46576651","properties":[{"key":"Description","value":"-"}]},{"database":"CPTAC","id":"CPTAC-321","properties":[{"key":"Description","value":"-"}]},{"database":"CPTAC","id":"CPTAC-322","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q9HB71","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q9HB71","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000356652","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q9HB71","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"3636","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"63708","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"81499","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9HB71-1"},{"database":"ProteomicsDB","id":"81500","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9HB71-2"},{"database":"Pumba","id":"Q9HB71","properties":[{"key":"Description","value":"-"}]},{"database":"TopDownProteomics","id":"Q9HB71-1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9HB71-1"},{"database":"Antibodypedia","id":"20569","properties":[{"key":"antibodies","value":"381 antibodies from 37 providers"}]},{"database":"DNASU","id":"27101","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000367679.7","properties":[{"key":"ProteinId","value":"ENSP00000356652.2"},{"key":"GeneId","value":"ENSG00000116161.19"}],"isoformId":"Q9HB71-1"},{"database":"Ensembl","id":"ENST00000405362.1","properties":[{"key":"ProteinId","value":"ENSP00000385771.1"},{"key":"GeneId","value":"ENSG00000116161.19"}],"isoformId":"Q9HB71-3"},{"database":"Ensembl","id":"ENST00000406752.1","properties":[{"key":"ProteinId","value":"ENSP00000384139.1"},{"key":"GeneId","value":"ENSG00000116161.19"}],"isoformId":"Q9HB71-2"},{"database":"Ensembl","id":"ENST00000613570.4","properties":[{"key":"ProteinId","value":"ENSP00000479414.1"},{"key":"GeneId","value":"ENSG00000116161.19"}],"isoformId":"Q9HB71-3"},{"database":"GeneID","id":"27101","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:27101","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000367679.7","properties":[{"key":"ProteinId","value":"ENSP00000356652.2"},{"key":"RefSeqNucleotideId","value":"NM_014412.3"},{"key":"RefSeqProteinId","value":"NP_055227.1"}]},{"database":"UCSC","id":"uc001gki.2","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"Q9HB71-1"},{"database":"AGR","id":"HGNC:30423","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA134894213","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"27101","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"27101","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"CACYBP","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:30423","properties":[{"key":"GeneName","value":"CACYBP"}]},{"database":"HPA","id":"ENSG00000116161","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MIM","id":"606186","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000116161","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000116161","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG3260","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000016470","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_081441_2_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q9HB71","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"YGWDQSA","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"164025at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q9HB71","properties":[{"key":"Number of GO annotations","value":"5 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q9HB71","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q9HB71","properties":[{"key":"Description","value":"-"}]},{"database":"SignaLink","id":"Q9HB71","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000116161","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"27101","properties":[{"key":"hits","value":"37 hits in 1121 CRISPR screens"}]},{"database":"CD-CODE","id":"91857CE7","properties":[{"key":"EntryName","value":"Nucleolus"}]},{"database":"CD-CODE","id":"FB4E32DD","properties":[{"key":"EntryName","value":"Presynaptic clusters and postsynaptic densities"}]},{"database":"ChiTaRS","id":"CACYBP","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"Q9HB71","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"CACYBP","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"27101","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q9HB71","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:Q9HB71","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"RNAct","id":"Q9HB71","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000116161","properties":[{"key":"ExpressionPatterns","value":"Expressed in endothelial cell and 218 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q9HB71","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0030877","properties":[{"key":"GoTerm","value":"C:beta-catenin destruction complex"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16085652"}]},{"database":"GO","id":"GO:0044297","properties":[{"key":"GoTerm","value":"C:cell body"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0070062","properties":[{"key":"GoTerm","value":"C:extracellular exosome"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"20458337"}]},{"database":"GO","id":"GO:0005641","properties":[{"key":"GoTerm","value":"C:nuclear envelope lumen"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0019005","properties":[{"key":"GoTerm","value":"C:SCF ubiquitin ligase complex"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0060090","properties":[{"key":"GoTerm","value":"F:molecular adaptor activity"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0019904","properties":[{"key":"GoTerm","value":"F:protein domain specific binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0042803","properties":[{"key":"GoTerm","value":"F:protein homodimerization activity"},{"key":"GoEvidenceType","value":"IPI:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"16085652"}]},{"database":"GO","id":"GO:0044548","properties":[{"key":"GoTerm","value":"F:S100 protein binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0015631","properties":[{"key":"GoTerm","value":"F:tubulin binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0031625","properties":[{"key":"GoTerm","value":"F:ubiquitin protein ligase binding"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0055007","properties":[{"key":"GoTerm","value":"P:cardiac muscle cell differentiation"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0071277","properties":[{"key":"GoTerm","value":"P:cellular response to calcium ion"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0007507","properties":[{"key":"GoTerm","value":"P:heart development"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0045740","properties":[{"key":"GoTerm","value":"P:positive regulation of DNA replication"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0060416","properties":[{"key":"GoTerm","value":"P:response to growth hormone"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"CDD","id":"cd06468","properties":[{"key":"EntryName","value":"p23_CacyBP"},{"key":"MatchStatus","value":"1"}]},{"database":"DisProt","id":"DP00907","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9HB71-2"},{"database":"FunFam","id":"2.60.40.790:FF:000006","properties":[{"key":"EntryName","value":"calcyclin-binding protein-like"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"4.10.860.10:FF:000006","properties":[{"key":"EntryName","value":"calcyclin-binding protein-like"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.790","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"4.10.860.10","properties":[{"key":"EntryName","value":"UVR domain"},{"key":"MatchStatus","value":"1"}]},{"database":"IDEAL","id":"IID00125","properties":[{"key":"Description","value":"-"}]},{"database":"InterPro","id":"IPR037201","properties":[{"key":"EntryName","value":"CacyBP_N"}]},{"database":"InterPro","id":"IPR052289","properties":[{"key":"EntryName","value":"Calcyclin-binding_UBL-bridge"}]},{"database":"InterPro","id":"IPR037893","properties":[{"key":"EntryName","value":"CS_CacyBP"}]},{"database":"InterPro","id":"IPR007052","properties":[{"key":"EntryName","value":"CS_dom"}]},{"database":"InterPro","id":"IPR008978","properties":[{"key":"EntryName","value":"HSP20-like_chaperone"}]},{"database":"InterPro","id":"IPR007699","properties":[{"key":"EntryName","value":"SGS_dom"}]},{"database":"InterPro","id":"IPR015120","properties":[{"key":"EntryName","value":"Siah-Interact_N"}]},{"database":"PANTHER","id":"PTHR13164:SF3","properties":[{"key":"EntryName","value":"CALCYCLIN-BINDING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR13164","properties":[{"key":"EntryName","value":"CALICYLIN BINDING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04969","properties":[{"key":"EntryName","value":"CS"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF05002","properties":[{"key":"EntryName","value":"SGS"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF09032","properties":[{"key":"EntryName","value":"Siah-Interact_N"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF140106","properties":[{"key":"EntryName","value":"Calcyclin-binding protein-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF49764","properties":[{"key":"EntryName","value":"HSP20-like chaperones"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51203","properties":[{"key":"EntryName","value":"CS"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51048","properties":[{"key":"EntryName","value":"SGS"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MASEELQKDLEEVKVLLEKATRKRVRDALTAEKSKIETEIKNKMQQKSQKKAELLDNEKPAAVVAPITTGYTVKISNYGWDQSDKFVKIYITLTGVHQVPTENVQVHFTERSFDLLVKNLNGKSYSMIVNNLLKPISVEGSSKKVKTDTVLILCRKKVENTRWDYLTQVEKECKEKEKPSYDTETDPSEGLMNVLKKIYEDGDDDMKRTINKAWVESREKQAKGDTEF","length":228,"molWeight":26210,"crc64":"88C822FB14A7EF89","md5":"EB41A31EF7E586250AFECE10B5D8D4B6"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"INTERACTION":26,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":3,"PTM":1,"SEQUENCE CAUTION":2},"countByFeatureType":{"Initiator methionine":1,"Chain":1,"Domain":2,"Region":3,"Modified residue":8,"Alternative sequence":3,"Mutagenesis":3,"Sequence conflict":4,"Helix":3,"Beta strand":12,"Turn":2},"uniParcId":"UPI0000032D9C"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q6NVY0","uniProtkbId":"Q6NVY0_HUMAN","entryAudit":{"firstPublicDate":"2004-07-05","lastAnnotationUpdateDate":"2025-06-18","lastSequenceUpdateDate":"2004-07-05","entryVersion":94,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAH67823.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00015702"}],"value":"Calcyclin-binding protein"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAH67823.1"}],"value":"CACYBP"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00025145"}],"value":"May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1)"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004496"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004123"}],"value":"Nucleus","id":"SL-0191"}}]}],"features":[{"type":"Domain","location":{"start":{"value":73,"modifier":"EXACT"},"end":{"value":167,"modifier":"EXACT"}},"description":"CS","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51203"}]},{"type":"Domain","location":{"start":{"value":151,"modifier":"EXACT"},"end":{"value":228,"modifier":"EXACT"}},"description":"SGS","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51048"}]},{"type":"Coiled coil","location":{"start":{"value":3,"modifier":"EXACT"},"end":{"value":57,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022990"}],"id":"KW-0007","category":"PTM","name":"Acetylation"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022786"}],"id":"KW-0833","category":"Biological process","name":"Ubl conjugation pathway"}],"references":[{"referenceNumber":1,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"authors":["Gerhard D.S.","Wagner L.","Feingold E.A.","Shenmen C.M.","Grouse L.H.","Schuler G.","Klein S.L.","Old S.","Rasooly R.","Good P.","Guyer M.","Peck A.M.","Derge J.G.","Lipman D.","Collins F.S.","Jang W.","Sherry S.","Feolo M.","Misquitta L.","Lee E.","Rotmistrovsky K.","Greenhut S.F.","Schaefer C.F.","Buetow K.","Bonner T.I.","Haussler D.","Kent J.","Kiekhaus M.","Furey T.","Brent M.","Prange C.","Schreiber K.","Shapiro N.","Bhat N.K.","Hopkins R.F.","Hsie F.","Driscoll T.","Soares M.B.","Casavant T.L.","Scheetz T.E.","Brown-stein M.J.","Usdin T.B.","Toshiyuki S.","Carninci P.","Piao Y.","Dudekula D.B.","Ko M.S.","Kawakami K.","Suzuki Y.","Sugano S.","Gruber C.E.","Smith M.R.","Simmons B.","Moore T.","Waterman R.","Johnson S.L.","Ruan Y.","Wei C.L.","Mathavan S.","Gunaratne P.H.","Wu J.","Garcia A.M.","Hulyk S.W.","Fuh E.","Yuan Y.","Sneed A.","Kowis C.","Hodgson A.","Muzny D.M.","McPherson J.","Gibbs R.A.","Fahey J.","Helton E.","Ketteman M.","Madan A.","Rodrigues S.","Sanchez A.","Whiting M.","Madari A.","Young A.C.","Wetherby K.D.","Granite S.J.","Kwong P.N.","Brinkley C.P.","Pearson R.L.","Bouffard G.G.","Blakesly R.W.","Green E.D.","Dickson M.C.","Rodriguez A.C.","Grimwood J.","Schmutz J.","Myers R.M.","Butterfield Y.S.","Griffith M.","Griffith O.L.","Krzywinski M.I.","Liao N.","Morin R.","Morrin R.","Palmquist D.","Petrescu A.S.","Skalska U.","Smailus D.E.","Stott J.M.","Schnerch A.","Schein J.E.","Jones S.J.","Holt R.A.","Baross A.","Marra M.A.","Clifton S.","Makowski K.A.","Bosak S.","Malek J."],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAH67823.1"}],"value":"Brain","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAH67823.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"BC067823","properties":[{"key":"ProteinId","value":"AAH67823.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"Q6NVY0","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q6NVY0","properties":[{"key":"Description","value":"-"}]},{"database":"IntAct","id":"Q6NVY0","properties":[{"key":"Interactions","value":"1"}]},{"database":"SwissPalm","id":"Q6NVY0","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q6NVY0","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"164025at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"CACYBP","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0044548","properties":[{"key":"GoTerm","value":"F:S100 protein binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0015631","properties":[{"key":"GoTerm","value":"F:tubulin binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0031625","properties":[{"key":"GoTerm","value":"F:ubiquitin protein ligase binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd06468","properties":[{"key":"EntryName","value":"p23_CacyBP"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.790:FF:000006","properties":[{"key":"EntryName","value":"calcyclin-binding protein-like"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"4.10.860.10:FF:000006","properties":[{"key":"EntryName","value":"calcyclin-binding protein-like"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.790","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"4.10.860.10","properties":[{"key":"EntryName","value":"UVR domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR037201","properties":[{"key":"EntryName","value":"CacyBP_N"}]},{"database":"InterPro","id":"IPR052289","properties":[{"key":"EntryName","value":"Calcyclin-binding_UBL-bridge"}]},{"database":"InterPro","id":"IPR037893","properties":[{"key":"EntryName","value":"CS_CacyBP"}]},{"database":"InterPro","id":"IPR007052","properties":[{"key":"EntryName","value":"CS_dom"}]},{"database":"InterPro","id":"IPR008978","properties":[{"key":"EntryName","value":"HSP20-like_chaperone"}]},{"database":"InterPro","id":"IPR007699","properties":[{"key":"EntryName","value":"SGS_dom"}]},{"database":"InterPro","id":"IPR015120","properties":[{"key":"EntryName","value":"Siah-Interact_N"}]},{"database":"PANTHER","id":"PTHR13164:SF3","properties":[{"key":"EntryName","value":"CALCYCLIN-BINDING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR13164","properties":[{"key":"EntryName","value":"CALICYLIN BINDING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04969","properties":[{"key":"EntryName","value":"CS"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF05002","properties":[{"key":"EntryName","value":"SGS"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF09032","properties":[{"key":"EntryName","value":"Siah-Interact_N"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF140106","properties":[{"key":"EntryName","value":"Calcyclin-binding protein-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF49764","properties":[{"key":"EntryName","value":"HSP20-like chaperones"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51203","properties":[{"key":"EntryName","value":"CS"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51048","properties":[{"key":"EntryName","value":"SGS"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MASEELQKDLEEVKVLLEKATRKRVRDALTAEKSKIETEIKNKMQQKSQKKAELLDNEKPAAVVAPITTGYTVKISNYGWDQSDKFVKIYITLTGVHQVPTENVQVHFTERSFDLLVKNLNGKSYSMIVNNLLKPISVEGSSKKVKTDTVLILCRKKVENTRWDYLTQVEKECKEKEKPSYDTETDPSEGLMNVLKKIYEDGDDDMKQTINKAWVESREKQAKGDTEF","length":228,"molWeight":26182,"crc64":"88C822FB16CA7F89","md5":"9C38DEDC9815C758E003011C2422EB6B"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Domain":2,"Coiled coil":1},"uniParcId":"UPI0000350819"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8T9A4","uniProtkbId":"A0ACI8T9A4_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000594741.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000594741.1"}],"value":"Calcyclin binding protein"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000594741.1"}],"value":"CACYBP"}}],"features":[{"type":"Domain","location":{"start":{"value":12,"modifier":"EXACT"},"end":{"value":89,"modifier":"EXACT"}},"description":"SGS","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51048"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8T9A4"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8T9A4"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000594741.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000594741.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16710414","citationType":"journal article","authors":["Gregory S.G.","Barlow K.F.","McLay K.E.","Kaul R.","Swarbreck D.","Dunham A.","Scott C.E.","Howe K.L.","Woodfine K.","Spencer C.C.","Jones M.C.","Gillson C.","Searle S.","Zhou Y.","Kokocinski F.","McDonald L.","Evans R.","Phillips K.","Atkinson A.","Cooper R.","Jones C.","Hall R.E.","Andrews T.D.","Lloyd C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Anderson F.","Andrew R.W.","Ashwell R.I.","Aubin K.","Babbage A.K.","Bagguley C.L.","Bailey J.","Beasley H.","Bethel G.","Bird C.P.","Bray-Allen S.","Brown J.Y.","Brown A.J.","Buckley D.","Burton J.","Bye J.","Carder C.","Chapman J.C.","Clark S.Y.","Clarke G.","Clee C.","Cobley V.","Collier R.E.","Corby N.","Coville G.J.","Davies J.","Deadman R.","Dunn M.","Earthrowl M.","Ellington A.G.","Errington H.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Gay L.","Ghori M.R.","Gibson R.","Gilby L.M.","Gillett W.","Glithero R.J.","Grafham D.V.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Hammond S.","Harrison E.S.","Hart E.","Haugen E.","Heath P.D.","Holmes S.","Holt K.","Howden P.J.","Hunt A.R.","Hunt S.E.","Hunter G.","Isherwood J.","James R.","Johnson C.","Johnson D.","Joy A.","Kay M.","Kershaw J.K.","Kibukawa M.","Kimberley A.M.","King A.","Knights A.J.","Lad H.","Laird G.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Loveland J.","Lovell J.","Lush M.J.","Lyne R.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","Matthews N.S.","McLaren S.","Milne S.","Mistry S.","Moore M.J.","Nickerson T.","O'Dell C.N.","Oliver K.","Palmeiri A.","Palmer S.A.","Parker A.","Patel D.","Pearce A.V.","Peck A.I.","Pelan S.","Phelps K.","Phillimore B.J.","Plumb R.","Rajan J.","Raymond C.","Rouse G.","Saenphimmachak C.","Sehra H.K.","Sheridan E.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.","Steward C.","Subramanian S.","Sycamore N.","Tracey A.","Tromans A.","Van Helmond Z.","Wall M.","Wallis J.M.","White S.","Whitehead S.L.","Wilkinson J.E.","Willey D.L.","Williams H.","Wilming L.","Wray P.W.","Wu Z.","Coulson A.","Vaudin M.","Sulston J.E.","Durbin R.","Hubbard T.","Wooster R.","Dunham I.","Carter N.P.","McVean G.","Ross M.T.","Harrow J.","Olson M.V.","Beck S.","Rogers J.","Bentley D.R.","Banerjee R.","Bryant S.P.","Burford D.C.","Burrill W.D.","Clegg S.M.","Dhami P.","Dovey O.","Faulkner L.M.","Gribble S.M.","Langford C.F.","Pandian R.D.","Porter K.M.","Prigmore E."],"citationCrossReferences":[{"database":"PubMed","id":"16710414"},{"database":"DOI","id":"10.1038/nature04727"}],"title":"The DNA sequence and biological annotation of human chromosome 1.","publicationDate":"2006","journal":"Nature","firstPage":"315","lastPage":"321","volume":"441"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000594741.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000594741.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KF510703","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"Z99127","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000924682.1","properties":[{"key":"ProteinId","value":"ENSP00000594741.1"},{"key":"GeneId","value":"ENSG00000116161.19"}]},{"database":"HGNC","id":"HGNC:30423","properties":[{"key":"GeneName","value":"CACYBP"}]},{"database":"OpenTargets","id":"ENSG00000116161","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00390000016470","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"InterPro","id":"IPR052289","properties":[{"key":"EntryName","value":"Calcyclin-binding_UBL-bridge"}]},{"database":"InterPro","id":"IPR008978","properties":[{"key":"EntryName","value":"HSP20-like_chaperone"}]},{"database":"InterPro","id":"IPR007699","properties":[{"key":"EntryName","value":"SGS_dom"}]},{"database":"PANTHER","id":"PTHR13164:SF3","properties":[{"key":"EntryName","value":"CALCYCLIN-BINDING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR13164","properties":[{"key":"EntryName","value":"CALICYLIN BINDING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF05002","properties":[{"key":"EntryName","value":"SGS"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF49764","properties":[{"key":"EntryName","value":"HSP20-like chaperones"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51048","properties":[{"key":"EntryName","value":"SGS"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MASEEVKTDTVLILCRKKVENTRWDYLTQVEKECKEKEKPSYDTETDPSEGLMNVLKKIYEDGDDDMKRTINKAWVESREKQAKGDTEF","length":89,"molWeight":10467,"crc64":"98BD9E9AEA271971","md5":"ACC10F74287A05B9AD5EB090262E2D71"},"extraAttributes":{"countByFeatureType":{"Domain":1},"uniParcId":"UPI0040318F38"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8T9A6","uniProtkbId":"A0ACI8T9A6_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000594742.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00015702"}],"value":"Calcyclin-binding protein"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000594742.1"}],"value":"CACYBP"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00025145"}],"value":"May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1)"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004496"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004123"}],"value":"Nucleus","id":"SL-0191"}}]}],"features":[{"type":"Domain","location":{"start":{"value":107,"modifier":"EXACT"},"end":{"value":184,"modifier":"EXACT"}},"description":"SGS","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51048"}]},{"type":"Coiled coil","location":{"start":{"value":3,"modifier":"EXACT"},"end":{"value":57,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022990"}],"id":"KW-0007","category":"PTM","name":"Acetylation"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8T9A6"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8T9A6"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022786"}],"id":"KW-0833","category":"Biological process","name":"Ubl conjugation pathway"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000594742.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000594742.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16710414","citationType":"journal article","authors":["Gregory S.G.","Barlow K.F.","McLay K.E.","Kaul R.","Swarbreck D.","Dunham A.","Scott C.E.","Howe K.L.","Woodfine K.","Spencer C.C.","Jones M.C.","Gillson C.","Searle S.","Zhou Y.","Kokocinski F.","McDonald L.","Evans R.","Phillips K.","Atkinson A.","Cooper R.","Jones C.","Hall R.E.","Andrews T.D.","Lloyd C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Anderson F.","Andrew R.W.","Ashwell R.I.","Aubin K.","Babbage A.K.","Bagguley C.L.","Bailey J.","Beasley H.","Bethel G.","Bird C.P.","Bray-Allen S.","Brown J.Y.","Brown A.J.","Buckley D.","Burton J.","Bye J.","Carder C.","Chapman J.C.","Clark S.Y.","Clarke G.","Clee C.","Cobley V.","Collier R.E.","Corby N.","Coville G.J.","Davies J.","Deadman R.","Dunn M.","Earthrowl M.","Ellington A.G.","Errington H.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Gay L.","Ghori M.R.","Gibson R.","Gilby L.M.","Gillett W.","Glithero R.J.","Grafham D.V.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Hammond S.","Harrison E.S.","Hart E.","Haugen E.","Heath P.D.","Holmes S.","Holt K.","Howden P.J.","Hunt A.R.","Hunt S.E.","Hunter G.","Isherwood J.","James R.","Johnson C.","Johnson D.","Joy A.","Kay M.","Kershaw J.K.","Kibukawa M.","Kimberley A.M.","King A.","Knights A.J.","Lad H.","Laird G.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Loveland J.","Lovell J.","Lush M.J.","Lyne R.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","Matthews N.S.","McLaren S.","Milne S.","Mistry S.","Moore M.J.","Nickerson T.","O'Dell C.N.","Oliver K.","Palmeiri A.","Palmer S.A.","Parker A.","Patel D.","Pearce A.V.","Peck A.I.","Pelan S.","Phelps K.","Phillimore B.J.","Plumb R.","Rajan J.","Raymond C.","Rouse G.","Saenphimmachak C.","Sehra H.K.","Sheridan E.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.","Steward C.","Subramanian S.","Sycamore N.","Tracey A.","Tromans A.","Van Helmond Z.","Wall M.","Wallis J.M.","White S.","Whitehead S.L.","Wilkinson J.E.","Willey D.L.","Williams H.","Wilming L.","Wray P.W.","Wu Z.","Coulson A.","Vaudin M.","Sulston J.E.","Durbin R.","Hubbard T.","Wooster R.","Dunham I.","Carter N.P.","McVean G.","Ross M.T.","Harrow J.","Olson M.V.","Beck S.","Rogers J.","Bentley D.R.","Banerjee R.","Bryant S.P.","Burford D.C.","Burrill W.D.","Clegg S.M.","Dhami P.","Dovey O.","Faulkner L.M.","Gribble S.M.","Langford C.F.","Pandian R.D.","Porter K.M.","Prigmore E."],"citationCrossReferences":[{"database":"PubMed","id":"16710414"},{"database":"DOI","id":"10.1038/nature04727"}],"title":"The DNA sequence and biological annotation of human chromosome 1.","publicationDate":"2006","journal":"Nature","firstPage":"315","lastPage":"321","volume":"441"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000594742.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000594742.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KF510703","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"Z99127","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000924683.1","properties":[{"key":"ProteinId","value":"ENSP00000594742.1"},{"key":"GeneId","value":"ENSG00000116161.19"}]},{"database":"HGNC","id":"HGNC:30423","properties":[{"key":"GeneName","value":"CACYBP"}]},{"database":"OpenTargets","id":"ENSG00000116161","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00390000016470","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"FunFam","id":"4.10.860.10:FF:000006","properties":[{"key":"EntryName","value":"calcyclin-binding protein-like"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.790","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"4.10.860.10","properties":[{"key":"EntryName","value":"UVR domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR037201","properties":[{"key":"EntryName","value":"CacyBP_N"}]},{"database":"InterPro","id":"IPR052289","properties":[{"key":"EntryName","value":"Calcyclin-binding_UBL-bridge"}]},{"database":"InterPro","id":"IPR007052","properties":[{"key":"EntryName","value":"CS_dom"}]},{"database":"InterPro","id":"IPR008978","properties":[{"key":"EntryName","value":"HSP20-like_chaperone"}]},{"database":"InterPro","id":"IPR007699","properties":[{"key":"EntryName","value":"SGS_dom"}]},{"database":"InterPro","id":"IPR015120","properties":[{"key":"EntryName","value":"Siah-Interact_N"}]},{"database":"PANTHER","id":"PTHR13164:SF3","properties":[{"key":"EntryName","value":"CALCYCLIN-BINDING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR13164","properties":[{"key":"EntryName","value":"CALICYLIN BINDING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04969","properties":[{"key":"EntryName","value":"CS"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF05002","properties":[{"key":"EntryName","value":"SGS"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF09032","properties":[{"key":"EntryName","value":"Siah-Interact_N"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF140106","properties":[{"key":"EntryName","value":"Calcyclin-binding protein-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF49764","properties":[{"key":"EntryName","value":"HSP20-like chaperones"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51048","properties":[{"key":"EntryName","value":"SGS"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MASEELQKDLEEVKVLLEKATRKRVRDALTAEKSKIETEIKNKMQQKSQKKAELLDNEKPAAVVAPITTGYTVKISNYGWDQSDKFVKIYITLTGVHQVPTENVQVHFTERKKVENTRWDYLTQVEKECKEKEKPSYDTETDPSEGLMNVLKKIYEDGDDDMKRTINKAWVESREKQAKGDTEF","length":184,"molWeight":21361,"crc64":"023E08EE7D18562A","md5":"BC05F79A42008034543D4C7AEF31DFCF"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Domain":1,"Coiled coil":1},"uniParcId":"UPI0040320155"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"B2ZWH1","uniProtkbId":"B2ZWH1_HUMAN","entryAudit":{"firstPublicDate":"2008-07-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2008-07-01","entryVersion":115,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000403674.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000403674.1"}],"value":"Calcyclin binding protein"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000403674.1"}],"value":"CACYBP"}}],"features":[{"type":"Domain","location":{"start":{"value":4,"modifier":"EXACT"},"end":{"value":49,"modifier":"EXACT"}},"description":"Siah interacting protein N-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF09032"}]},{"type":"Coiled coil","location":{"start":{"value":3,"modifier":"EXACT"},"end":{"value":46,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Non-terminal residue","location":{"start":{"value":50,"modifier":"EXACT"},"end":{"value":50,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000403674.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"B2ZWH1"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"B2ZWH1"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000403674.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000403674.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16710414","citationType":"journal article","authors":["Gregory S.G.","Barlow K.F.","McLay K.E.","Kaul R.","Swarbreck D.","Dunham A.","Scott C.E.","Howe K.L.","Woodfine K.","Spencer C.C.","Jones M.C.","Gillson C.","Searle S.","Zhou Y.","Kokocinski F.","McDonald L.","Evans R.","Phillips K.","Atkinson A.","Cooper R.","Jones C.","Hall R.E.","Andrews T.D.","Lloyd C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Anderson F.","Andrew R.W.","Ashwell R.I.","Aubin K.","Babbage A.K.","Bagguley C.L.","Bailey J.","Beasley H.","Bethel G.","Bird C.P.","Bray-Allen S.","Brown J.Y.","Brown A.J.","Buckley D.","Burton J.","Bye J.","Carder C.","Chapman J.C.","Clark S.Y.","Clarke G.","Clee C.","Cobley V.","Collier R.E.","Corby N.","Coville G.J.","Davies J.","Deadman R.","Dunn M.","Earthrowl M.","Ellington A.G.","Errington H.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Gay L.","Ghori M.R.","Gibson R.","Gilby L.M.","Gillett W.","Glithero R.J.","Grafham D.V.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Hammond S.","Harrison E.S.","Hart E.","Haugen E.","Heath P.D.","Holmes S.","Holt K.","Howden P.J.","Hunt A.R.","Hunt S.E.","Hunter G.","Isherwood J.","James R.","Johnson C.","Johnson D.","Joy A.","Kay M.","Kershaw J.K.","Kibukawa M.","Kimberley A.M.","King A.","Knights A.J.","Lad H.","Laird G.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Loveland J.","Lovell J.","Lush M.J.","Lyne R.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","Matthews N.S.","McLaren S.","Milne S.","Mistry S.","Moore M.J.","Nickerson T.","O'Dell C.N.","Oliver K.","Palmeiri A.","Palmer S.A.","Parker A.","Patel D.","Pearce A.V.","Peck A.I.","Pelan S.","Phelps K.","Phillimore B.J.","Plumb R.","Rajan J.","Raymond C.","Rouse G.","Saenphimmachak C.","Sehra H.K.","Sheridan E.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.","Steward C.","Subramanian S.","Sycamore N.","Tracey A.","Tromans A.","Van Helmond Z.","Wall M.","Wallis J.M.","White S.","Whitehead S.L.","Wilkinson J.E.","Willey D.L.","Williams H.","Wilming L.","Wray P.W.","Wu Z.","Coulson A.","Vaudin M.","Sulston J.E.","Durbin R.","Hubbard T.","Wooster R.","Dunham I.","Carter N.P.","McVean G.","Ross M.T.","Harrow J.","Olson M.V.","Beck S.","Rogers J.","Bentley D.R.","Banerjee R.","Bryant S.P.","Burford D.C.","Burrill W.D.","Clegg S.M.","Dhami P.","Dovey O.","Faulkner L.M.","Gribble S.M.","Langford C.F.","Pandian R.D.","Porter K.M.","Prigmore E."],"citationCrossReferences":[{"database":"PubMed","id":"16710414"},{"database":"DOI","id":"10.1038/nature04727"}],"title":"The DNA sequence and biological annotation of human chromosome 1.","publicationDate":"2006","journal":"Nature","firstPage":"315","lastPage":"321","volume":"441"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000403674.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"19413330","citationType":"journal article","authors":["Gauci S.","Helbig A.O.","Slijper M.","Krijgsveld J.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"19413330"},{"database":"DOI","id":"10.1021/ac9004309"}],"title":"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.","publicationDate":"2009","journal":"Anal. Chem.","firstPage":"4493","lastPage":"4501","volume":"81"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"19413330"}]},{"referenceNumber":5,"citation":{"id":"19608861","citationType":"journal article","authors":["Choudhary C.","Kumar C.","Gnad F.","Nielsen M.L.","Rehman M.","Walther T.C.","Olsen J.V.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"19608861"},{"database":"DOI","id":"10.1126/science.1175371"}],"title":"Lysine acetylation targets protein complexes and co-regulates major cellular functions.","publicationDate":"2009","journal":"Science","firstPage":"834","lastPage":"840","volume":"325"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"19608861"}]},{"referenceNumber":6,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Burckstummer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"21269460"}]},{"referenceNumber":7,"citation":{"id":"22223895","citationType":"journal article","authors":["Bienvenut W.V.","Sumpton D.","Martinez A.","Lilla S.","Espagne C.","Meinnel T.","Giglione C."],"citationCrossReferences":[{"database":"PubMed","id":"22223895"},{"database":"DOI","id":"10.1074/mcp.M111.015131"}],"title":"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.","publicationDate":"2012","journal":"Mol. Cell. Proteomics","firstPage":"M111.015131","lastPage":"M111.015131","volume":"11"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"22223895"}]},{"referenceNumber":8,"citation":{"id":"22814378","citationType":"journal article","authors":["Van Damme P.","Lasa M.","Polevoda B.","Gazquez C.","Elosegui-Artola A.","Kim D.S.","De Juan-Pardo E.","Demeyer K.","Hole K.","Larrea E.","Timmerman E.","Prieto J.","Arnesen T.","Sherman F.","Gevaert K.","Aldabe R."],"citationCrossReferences":[{"database":"PubMed","id":"22814378"},{"database":"DOI","id":"10.1073/pnas.1210303109"}],"title":"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.","publicationDate":"2012","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"12449","lastPage":"12454","volume":"109"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"22814378"}]},{"referenceNumber":9,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"23186163"}]},{"referenceNumber":10,"citation":{"id":"25944712","citationType":"journal article","authors":["Vaca Jacome A.S.","Rabilloud T.","Schaeffer-Reiss C.","Rompais M.","Ayoub D.","Lane L.","Bairoch A.","Van Dorsselaer A.","Carapito C."],"citationCrossReferences":[{"database":"PubMed","id":"25944712"}],"title":"N-terminome analysis of the human mitochondrial proteome.","publicationDate":"2015","journal":"Proteomics","firstPage":"2519","lastPage":"2524","volume":"15"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"25944712"}]},{"referenceNumber":11,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000403674.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KF510703","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"Z99127","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"B2ZWH1","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"B2ZWH1","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"B2ZWH1","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"3470","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"20569","properties":[{"key":"antibodies","value":"381 antibodies from 37 providers"}]},{"database":"Ensembl","id":"ENST00000426793.1","properties":[{"key":"ProteinId","value":"ENSP00000403674.1"},{"key":"GeneId","value":"ENSG00000116161.19"}]},{"database":"UCSC","id":"uc057nly.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:30423","properties":[{"key":"GeneName","value":"CACYBP"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000116161","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00390000016470","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_3129431_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"YGWDQSA","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"164025at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"CACYBP","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"Bgee","id":"ENSG00000116161","properties":[{"key":"ExpressionPatterns","value":"Expressed in endothelial cell and 218 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"B2ZWH1","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"FunFam","id":"4.10.860.10:FF:000006","properties":[{"key":"EntryName","value":"calcyclin-binding protein-like"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"4.10.860.10","properties":[{"key":"EntryName","value":"UVR domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR037201","properties":[{"key":"EntryName","value":"CacyBP_N"}]},{"database":"InterPro","id":"IPR052289","properties":[{"key":"EntryName","value":"Calcyclin-binding_UBL-bridge"}]},{"database":"InterPro","id":"IPR015120","properties":[{"key":"EntryName","value":"Siah-Interact_N"}]},{"database":"PANTHER","id":"PTHR13164:SF3","properties":[{"key":"EntryName","value":"CALCYCLIN-BINDING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR13164","properties":[{"key":"EntryName","value":"CALICYLIN BINDING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF09032","properties":[{"key":"EntryName","value":"Siah-Interact_N"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF140106","properties":[{"key":"EntryName","value":"Calcyclin-binding protein-like"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MASEELQKDLEEVKVLLEKATRKRVRDALTAEKSKIETEIKNKMQQKSQK","length":50,"molWeight":5859,"crc64":"F9729E6DAD674D94","md5":"56544FAF760BCB0FA6DC39F111AAE28B"},"extraAttributes":{"countByFeatureType":{"Domain":1,"Coiled coil":1,"Non-terminal residue":1},"uniParcId":"UPI000173A6E6"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8S554","uniProtkbId":"A0ACI8S554_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000571154.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00015702"}],"value":"Calcyclin-binding protein"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000571154.1"}],"value":"CACYBP"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00025145"}],"value":"May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1)"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004496"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004123"}],"value":"Nucleus","id":"SL-0191"}}]}],"features":[{"type":"Domain","location":{"start":{"value":70,"modifier":"EXACT"},"end":{"value":164,"modifier":"EXACT"}},"description":"CS","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51203"}]},{"type":"Domain","location":{"start":{"value":148,"modifier":"EXACT"},"end":{"value":225,"modifier":"EXACT"}},"description":"SGS","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51048"}]},{"type":"Coiled coil","location":{"start":{"value":3,"modifier":"EXACT"},"end":{"value":57,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022990"}],"id":"KW-0007","category":"PTM","name":"Acetylation"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8S554"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8S554"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022786"}],"id":"KW-0833","category":"Biological process","name":"Ubl conjugation pathway"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000571154.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000571154.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16710414","citationType":"journal article","authors":["Gregory S.G.","Barlow K.F.","McLay K.E.","Kaul R.","Swarbreck D.","Dunham A.","Scott C.E.","Howe K.L.","Woodfine K.","Spencer C.C.","Jones M.C.","Gillson C.","Searle S.","Zhou Y.","Kokocinski F.","McDonald L.","Evans R.","Phillips K.","Atkinson A.","Cooper R.","Jones C.","Hall R.E.","Andrews T.D.","Lloyd C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Anderson F.","Andrew R.W.","Ashwell R.I.","Aubin K.","Babbage A.K.","Bagguley C.L.","Bailey J.","Beasley H.","Bethel G.","Bird C.P.","Bray-Allen S.","Brown J.Y.","Brown A.J.","Buckley D.","Burton J.","Bye J.","Carder C.","Chapman J.C.","Clark S.Y.","Clarke G.","Clee C.","Cobley V.","Collier R.E.","Corby N.","Coville G.J.","Davies J.","Deadman R.","Dunn M.","Earthrowl M.","Ellington A.G.","Errington H.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Gay L.","Ghori M.R.","Gibson R.","Gilby L.M.","Gillett W.","Glithero R.J.","Grafham D.V.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Hammond S.","Harrison E.S.","Hart E.","Haugen E.","Heath P.D.","Holmes S.","Holt K.","Howden P.J.","Hunt A.R.","Hunt S.E.","Hunter G.","Isherwood J.","James R.","Johnson C.","Johnson D.","Joy A.","Kay M.","Kershaw J.K.","Kibukawa M.","Kimberley A.M.","King A.","Knights A.J.","Lad H.","Laird G.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Loveland J.","Lovell J.","Lush M.J.","Lyne R.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","Matthews N.S.","McLaren S.","Milne S.","Mistry S.","Moore M.J.","Nickerson T.","O'Dell C.N.","Oliver K.","Palmeiri A.","Palmer S.A.","Parker A.","Patel D.","Pearce A.V.","Peck A.I.","Pelan S.","Phelps K.","Phillimore B.J.","Plumb R.","Rajan J.","Raymond C.","Rouse G.","Saenphimmachak C.","Sehra H.K.","Sheridan E.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.","Steward C.","Subramanian S.","Sycamore N.","Tracey A.","Tromans A.","Van Helmond Z.","Wall M.","Wallis J.M.","White S.","Whitehead S.L.","Wilkinson J.E.","Willey D.L.","Williams H.","Wilming L.","Wray P.W.","Wu Z.","Coulson A.","Vaudin M.","Sulston J.E.","Durbin R.","Hubbard T.","Wooster R.","Dunham I.","Carter N.P.","McVean G.","Ross M.T.","Harrow J.","Olson M.V.","Beck S.","Rogers J.","Bentley D.R.","Banerjee R.","Bryant S.P.","Burford D.C.","Burrill W.D.","Clegg S.M.","Dhami P.","Dovey O.","Faulkner L.M.","Gribble S.M.","Langford C.F.","Pandian R.D.","Porter K.M.","Prigmore E."],"citationCrossReferences":[{"database":"PubMed","id":"16710414"},{"database":"DOI","id":"10.1038/nature04727"}],"title":"The DNA sequence and biological annotation of human chromosome 1.","publicationDate":"2006","journal":"Nature","firstPage":"315","lastPage":"321","volume":"441"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000571154.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000571154.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KF510703","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"Z99127","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000901095.1","properties":[{"key":"ProteinId","value":"ENSP00000571154.1"},{"key":"GeneId","value":"ENSG00000116161.19"}]},{"database":"HGNC","id":"HGNC:30423","properties":[{"key":"GeneName","value":"CACYBP"}]},{"database":"OpenTargets","id":"ENSG00000116161","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00390000016470","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"CDD","id":"cd06468","properties":[{"key":"EntryName","value":"p23_CacyBP"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.790:FF:000006","properties":[{"key":"EntryName","value":"calcyclin-binding protein-like"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"4.10.860.10:FF:000006","properties":[{"key":"EntryName","value":"calcyclin-binding protein-like"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.790","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"4.10.860.10","properties":[{"key":"EntryName","value":"UVR domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR037201","properties":[{"key":"EntryName","value":"CacyBP_N"}]},{"database":"InterPro","id":"IPR052289","properties":[{"key":"EntryName","value":"Calcyclin-binding_UBL-bridge"}]},{"database":"InterPro","id":"IPR037893","properties":[{"key":"EntryName","value":"CS_CacyBP"}]},{"database":"InterPro","id":"IPR007052","properties":[{"key":"EntryName","value":"CS_dom"}]},{"database":"InterPro","id":"IPR008978","properties":[{"key":"EntryName","value":"HSP20-like_chaperone"}]},{"database":"InterPro","id":"IPR007699","properties":[{"key":"EntryName","value":"SGS_dom"}]},{"database":"InterPro","id":"IPR015120","properties":[{"key":"EntryName","value":"Siah-Interact_N"}]},{"database":"PANTHER","id":"PTHR13164:SF3","properties":[{"key":"EntryName","value":"CALCYCLIN-BINDING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR13164","properties":[{"key":"EntryName","value":"CALICYLIN BINDING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF05002","properties":[{"key":"EntryName","value":"SGS"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF09032","properties":[{"key":"EntryName","value":"Siah-Interact_N"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF140106","properties":[{"key":"EntryName","value":"Calcyclin-binding protein-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF49764","properties":[{"key":"EntryName","value":"HSP20-like chaperones"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51203","properties":[{"key":"EntryName","value":"CS"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51048","properties":[{"key":"EntryName","value":"SGS"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MASEELQKDLEEVKVLLEKATRKRVRDALTAEKSKIETEIKNKMQQKSQKKAELLDNEKPAAVVAPITTGYTVKIRWDQSDKFVKIYITLTGVHQVPTENVQVHFTERSFDLLVKNLNGKSYSMIVNNLLKPISVEGSSKKVKTDTVLILCRKKVENTRWDYLTQVEKECKEKEKPSYDTETDPSEGLMNVLKKIYEDGDDDMKRTINKAWVESREKQAKGDTEF","length":225,"molWeight":25945,"crc64":"265CBCEB3D9CA445","md5":"2A8DDE91C2E5983AD89CE1CC5B21BA49"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Domain":2,"Coiled coil":1},"uniParcId":"UPI0040323255"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8T916","uniProtkbId":"A0ACI8T916_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000594740.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00015702"}],"value":"Calcyclin-binding protein"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000594740.1"}],"value":"CACYBP"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00025145"}],"value":"May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1)"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004496"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004123"}],"value":"Nucleus","id":"SL-0191"}}]}],"features":[{"type":"Domain","location":{"start":{"value":66,"modifier":"EXACT"},"end":{"value":162,"modifier":"EXACT"}},"description":"CS","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51203"}]},{"type":"Domain","location":{"start":{"value":146,"modifier":"EXACT"},"end":{"value":223,"modifier":"EXACT"}},"description":"SGS","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51048"}]},{"type":"Coiled coil","location":{"start":{"value":3,"modifier":"EXACT"},"end":{"value":57,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022990"}],"id":"KW-0007","category":"PTM","name":"Acetylation"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8T916"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8T916"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022786"}],"id":"KW-0833","category":"Biological process","name":"Ubl conjugation pathway"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000594740.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000594740.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16710414","citationType":"journal article","authors":["Gregory S.G.","Barlow K.F.","McLay K.E.","Kaul R.","Swarbreck D.","Dunham A.","Scott C.E.","Howe K.L.","Woodfine K.","Spencer C.C.","Jones M.C.","Gillson C.","Searle S.","Zhou Y.","Kokocinski F.","McDonald L.","Evans R.","Phillips K.","Atkinson A.","Cooper R.","Jones C.","Hall R.E.","Andrews T.D.","Lloyd C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Anderson F.","Andrew R.W.","Ashwell R.I.","Aubin K.","Babbage A.K.","Bagguley C.L.","Bailey J.","Beasley H.","Bethel G.","Bird C.P.","Bray-Allen S.","Brown J.Y.","Brown A.J.","Buckley D.","Burton J.","Bye J.","Carder C.","Chapman J.C.","Clark S.Y.","Clarke G.","Clee C.","Cobley V.","Collier R.E.","Corby N.","Coville G.J.","Davies J.","Deadman R.","Dunn M.","Earthrowl M.","Ellington A.G.","Errington H.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Gay L.","Ghori M.R.","Gibson R.","Gilby L.M.","Gillett W.","Glithero R.J.","Grafham D.V.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Hammond S.","Harrison E.S.","Hart E.","Haugen E.","Heath P.D.","Holmes S.","Holt K.","Howden P.J.","Hunt A.R.","Hunt S.E.","Hunter G.","Isherwood J.","James R.","Johnson C.","Johnson D.","Joy A.","Kay M.","Kershaw J.K.","Kibukawa M.","Kimberley A.M.","King A.","Knights A.J.","Lad H.","Laird G.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Loveland J.","Lovell J.","Lush M.J.","Lyne R.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","Matthews N.S.","McLaren S.","Milne S.","Mistry S.","Moore M.J.","Nickerson T.","O'Dell C.N.","Oliver K.","Palmeiri A.","Palmer S.A.","Parker A.","Patel D.","Pearce A.V.","Peck A.I.","Pelan S.","Phelps K.","Phillimore B.J.","Plumb R.","Rajan J.","Raymond C.","Rouse G.","Saenphimmachak C.","Sehra H.K.","Sheridan E.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.","Steward C.","Subramanian S.","Sycamore N.","Tracey A.","Tromans A.","Van Helmond Z.","Wall M.","Wallis J.M.","White S.","Whitehead S.L.","Wilkinson J.E.","Willey D.L.","Williams H.","Wilming L.","Wray P.W.","Wu Z.","Coulson A.","Vaudin M.","Sulston J.E.","Durbin R.","Hubbard T.","Wooster R.","Dunham I.","Carter N.P.","McVean G.","Ross M.T.","Harrow J.","Olson M.V.","Beck S.","Rogers J.","Bentley D.R.","Banerjee R.","Bryant S.P.","Burford D.C.","Burrill W.D.","Clegg S.M.","Dhami P.","Dovey O.","Faulkner L.M.","Gribble S.M.","Langford C.F.","Pandian R.D.","Porter K.M.","Prigmore E."],"citationCrossReferences":[{"database":"PubMed","id":"16710414"},{"database":"DOI","id":"10.1038/nature04727"}],"title":"The DNA sequence and biological annotation of human chromosome 1.","publicationDate":"2006","journal":"Nature","firstPage":"315","lastPage":"321","volume":"441"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000594740.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000594740.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KF510703","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"Z99127","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000924681.1","properties":[{"key":"ProteinId","value":"ENSP00000594740.1"},{"key":"GeneId","value":"ENSG00000116161.19"}]},{"database":"HGNC","id":"HGNC:30423","properties":[{"key":"GeneName","value":"CACYBP"}]},{"database":"OpenTargets","id":"ENSG00000116161","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00390000016470","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"CDD","id":"cd06468","properties":[{"key":"EntryName","value":"p23_CacyBP"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.790:FF:000006","properties":[{"key":"EntryName","value":"calcyclin-binding protein-like"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"4.10.860.10:FF:000006","properties":[{"key":"EntryName","value":"calcyclin-binding protein-like"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.790","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"4.10.860.10","properties":[{"key":"EntryName","value":"UVR domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR037201","properties":[{"key":"EntryName","value":"CacyBP_N"}]},{"database":"InterPro","id":"IPR052289","properties":[{"key":"EntryName","value":"Calcyclin-binding_UBL-bridge"}]},{"database":"InterPro","id":"IPR037893","properties":[{"key":"EntryName","value":"CS_CacyBP"}]},{"database":"InterPro","id":"IPR007052","properties":[{"key":"EntryName","value":"CS_dom"}]},{"database":"InterPro","id":"IPR008978","properties":[{"key":"EntryName","value":"HSP20-like_chaperone"}]},{"database":"InterPro","id":"IPR007699","properties":[{"key":"EntryName","value":"SGS_dom"}]},{"database":"InterPro","id":"IPR015120","properties":[{"key":"EntryName","value":"Siah-Interact_N"}]},{"database":"PANTHER","id":"PTHR13164:SF3","properties":[{"key":"EntryName","value":"CALCYCLIN-BINDING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR13164","properties":[{"key":"EntryName","value":"CALICYLIN BINDING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04969","properties":[{"key":"EntryName","value":"CS"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF05002","properties":[{"key":"EntryName","value":"SGS"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF09032","properties":[{"key":"EntryName","value":"Siah-Interact_N"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF140106","properties":[{"key":"EntryName","value":"Calcyclin-binding protein-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF49764","properties":[{"key":"EntryName","value":"HSP20-like chaperones"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51203","properties":[{"key":"EntryName","value":"CS"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51048","properties":[{"key":"EntryName","value":"SGS"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MASEELQKDLEEVKVLLEKATRKRVRDALTAEKSKIETEIKNKMQQKSQKKAELLDNEKPAAVVAPITTGYTVKISNYDKFVKIYITLTGVHQVPTENVQVHFTERSFDLLVKNLNGKSYSMIVNNLLKPISVEGSSKKVKTDTVLILCRKKVENTRWDYLTQVEKECKEKEKPSYDTETDPSEGLMNVLKKIYEDGDDDMKRTINKAWVESREKQAKGDTEF","length":223,"molWeight":25636,"crc64":"0800FB39FA7D5026","md5":"0C1303CD1003F338361BAC8C03E49E30"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Domain":2,"Coiled coil":1},"uniParcId":"UPI004031D0C7"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8T9I2","uniProtkbId":"A0ACI8T9I2_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000594743.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00015702"}],"value":"Calcyclin-binding protein"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000594743.1"}],"value":"CACYBP"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00025145"}],"value":"May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1)"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004496"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004123"}],"value":"Nucleus","id":"SL-0191"}}]}],"features":[{"type":"Domain","location":{"start":{"value":73,"modifier":"EXACT"},"end":{"value":173,"modifier":"EXACT"}},"description":"CS","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51203"}]},{"type":"Domain","location":{"start":{"value":138,"modifier":"EXACT"},"end":{"value":216,"modifier":"EXACT"}},"description":"SGS","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51048"}]},{"type":"Coiled coil","location":{"start":{"value":3,"modifier":"EXACT"},"end":{"value":57,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022990"}],"id":"KW-0007","category":"PTM","name":"Acetylation"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8T9I2"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8T9I2"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022786"}],"id":"KW-0833","category":"Biological process","name":"Ubl conjugation pathway"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000594743.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000594743.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16710414","citationType":"journal article","authors":["Gregory S.G.","Barlow K.F.","McLay K.E.","Kaul R.","Swarbreck D.","Dunham A.","Scott C.E.","Howe K.L.","Woodfine K.","Spencer C.C.","Jones M.C.","Gillson C.","Searle S.","Zhou Y.","Kokocinski F.","McDonald L.","Evans R.","Phillips K.","Atkinson A.","Cooper R.","Jones C.","Hall R.E.","Andrews T.D.","Lloyd C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Anderson F.","Andrew R.W.","Ashwell R.I.","Aubin K.","Babbage A.K.","Bagguley C.L.","Bailey J.","Beasley H.","Bethel G.","Bird C.P.","Bray-Allen S.","Brown J.Y.","Brown A.J.","Buckley D.","Burton J.","Bye J.","Carder C.","Chapman J.C.","Clark S.Y.","Clarke G.","Clee C.","Cobley V.","Collier R.E.","Corby N.","Coville G.J.","Davies J.","Deadman R.","Dunn M.","Earthrowl M.","Ellington A.G.","Errington H.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Gay L.","Ghori M.R.","Gibson R.","Gilby L.M.","Gillett W.","Glithero R.J.","Grafham D.V.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Hammond S.","Harrison E.S.","Hart E.","Haugen E.","Heath P.D.","Holmes S.","Holt K.","Howden P.J.","Hunt A.R.","Hunt S.E.","Hunter G.","Isherwood J.","James R.","Johnson C.","Johnson D.","Joy A.","Kay M.","Kershaw J.K.","Kibukawa M.","Kimberley A.M.","King A.","Knights A.J.","Lad H.","Laird G.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Loveland J.","Lovell J.","Lush M.J.","Lyne R.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","Matthews N.S.","McLaren S.","Milne S.","Mistry S.","Moore M.J.","Nickerson T.","O'Dell C.N.","Oliver K.","Palmeiri A.","Palmer S.A.","Parker A.","Patel D.","Pearce A.V.","Peck A.I.","Pelan S.","Phelps K.","Phillimore B.J.","Plumb R.","Rajan J.","Raymond C.","Rouse G.","Saenphimmachak C.","Sehra H.K.","Sheridan E.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.","Steward C.","Subramanian S.","Sycamore N.","Tracey A.","Tromans A.","Van Helmond Z.","Wall M.","Wallis J.M.","White S.","Whitehead S.L.","Wilkinson J.E.","Willey D.L.","Williams H.","Wilming L.","Wray P.W.","Wu Z.","Coulson A.","Vaudin M.","Sulston J.E.","Durbin R.","Hubbard T.","Wooster R.","Dunham I.","Carter N.P.","McVean G.","Ross M.T.","Harrow J.","Olson M.V.","Beck S.","Rogers J.","Bentley D.R.","Banerjee R.","Bryant S.P.","Burford D.C.","Burrill W.D.","Clegg S.M.","Dhami P.","Dovey O.","Faulkner L.M.","Gribble S.M.","Langford C.F.","Pandian R.D.","Porter K.M.","Prigmore E."],"citationCrossReferences":[{"database":"PubMed","id":"16710414"},{"database":"DOI","id":"10.1038/nature04727"}],"title":"The DNA sequence and biological annotation of human chromosome 1.","publicationDate":"2006","journal":"Nature","firstPage":"315","lastPage":"321","volume":"441"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000594743.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000594743.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KF510703","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"Z99127","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000924684.1","properties":[{"key":"ProteinId","value":"ENSP00000594743.1"},{"key":"GeneId","value":"ENSG00000116161.19"}]},{"database":"HGNC","id":"HGNC:30423","properties":[{"key":"GeneName","value":"CACYBP"}]},{"database":"OpenTargets","id":"ENSG00000116161","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00390000016470","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"CDD","id":"cd06468","properties":[{"key":"EntryName","value":"p23_CacyBP"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.790:FF:000006","properties":[{"key":"EntryName","value":"calcyclin-binding protein-like"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"4.10.860.10:FF:000006","properties":[{"key":"EntryName","value":"calcyclin-binding protein-like"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.790","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"4.10.860.10","properties":[{"key":"EntryName","value":"UVR domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR037201","properties":[{"key":"EntryName","value":"CacyBP_N"}]},{"database":"InterPro","id":"IPR052289","properties":[{"key":"EntryName","value":"Calcyclin-binding_UBL-bridge"}]},{"database":"InterPro","id":"IPR037893","properties":[{"key":"EntryName","value":"CS_CacyBP"}]},{"database":"InterPro","id":"IPR007052","properties":[{"key":"EntryName","value":"CS_dom"}]},{"database":"InterPro","id":"IPR008978","properties":[{"key":"EntryName","value":"HSP20-like_chaperone"}]},{"database":"InterPro","id":"IPR007699","properties":[{"key":"EntryName","value":"SGS_dom"}]},{"database":"InterPro","id":"IPR015120","properties":[{"key":"EntryName","value":"Siah-Interact_N"}]},{"database":"PANTHER","id":"PTHR13164:SF3","properties":[{"key":"EntryName","value":"CALCYCLIN-BINDING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR13164","properties":[{"key":"EntryName","value":"CALICYLIN BINDING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04969","properties":[{"key":"EntryName","value":"CS"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF05002","properties":[{"key":"EntryName","value":"SGS"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF09032","properties":[{"key":"EntryName","value":"Siah-Interact_N"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF140106","properties":[{"key":"EntryName","value":"Calcyclin-binding protein-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF49764","properties":[{"key":"EntryName","value":"HSP20-like chaperones"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51203","properties":[{"key":"EntryName","value":"CS"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51048","properties":[{"key":"EntryName","value":"SGS"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MASEELQKDLEEVKVLLEKATRKRVRDALTAEKSKIETEIKNKMQQKSQKKAELLDNEKPAAVVAPITTGYTVKISNYGWDQSDKFVKIYITLTGVHQVPTENVQVHFTERSFDLLVKNLNGKSYSMIVNNLLKPISVEGSSKKKVENTRWDYLTQVEKECKEKEKPSYDTETDPSEGLMNVLKKIYEDGDDDMKRTINKAWVESREKQAKGDTEF","length":216,"molWeight":24839,"crc64":"CFEDE8658C66D88A","md5":"927412D0A523E5338D7F70B7F7B5D1EB"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Domain":2,"Coiled coil":1},"uniParcId":"UPI0040322CC4"}}]}