{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q12983","secondaryAccessions":["O14620","Q96GP0"],"uniProtkbId":"BNIP3_HUMAN","entryAudit":{"firstPublicDate":"1999-07-15","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2022-05-25","entryVersion":221,"sequenceVersion":4},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"BCL2/adenovirus E1B 19 kDa protein-interacting protein 3"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:1084"}],"value":"BNIP3"},"synonyms":[{"value":"NIP3"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19935772"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22292033"}],"value":"Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10381623"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15868100"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18371312"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22292033"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38992176"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7954800"}],"value":"Homodimer. Binds to BCL2. Interacts with BNIP3L and ACAA2. Interacts (via BH3 domain) with SPATA18 (via coiled-coil domains). Interacts with BOK; promotes BOK oligomerization (PubMed:15868100). Interacts with PPTC7; this interaction promotes BNIP3 degradation (PubMed:38992176)"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7954800"}],"value":"(Microbial infection) Interacts with adenovirus E1B 19 kDa protein"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9575197"}],"value":"(Microbial infection) Interacts with Epstein-Barr virus BHRF1"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q12983","intActId":"EBI-749464"},"interactantTwo":{"uniProtKBAccession":"Q86WK6","geneName":"AMIGO1","intActId":"EBI-19125216"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q12983","intActId":"EBI-749464"},"interactantTwo":{"uniProtKBAccession":"Q3SXY8","geneName":"ARL13B","intActId":"EBI-11343438"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q12983","intActId":"EBI-749464"},"interactantTwo":{"uniProtKBAccession":"Q13323","geneName":"BIK","intActId":"EBI-700794"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q12983","intActId":"EBI-749464"},"interactantTwo":{"uniProtKBAccession":"Q12982","geneName":"BNIP2","intActId":"EBI-752094"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q12983","intActId":"EBI-749464"},"interactantTwo":{"uniProtKBAccession":"Q12983","geneName":"BNIP3","intActId":"EBI-749464"},"numberOfExperiments":8,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q12983","intActId":"EBI-749464"},"interactantTwo":{"uniProtKBAccession":"O60238","geneName":"BNIP3L","intActId":"EBI-849893"},"numberOfExperiments":25,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q12983","intActId":"EBI-749464"},"interactantTwo":{"uniProtKBAccession":"P07766","geneName":"CD3E","intActId":"EBI-1211297"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q12983","intActId":"EBI-749464"},"interactantTwo":{"uniProtKBAccession":"O95484","geneName":"CLDN9","intActId":"EBI-18341636"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q12983","intActId":"EBI-749464"},"interactantTwo":{"uniProtKBAccession":"Q9BXN2","geneName":"CLEC7A","intActId":"EBI-3939278"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q12983","intActId":"EBI-749464"},"interactantTwo":{"uniProtKBAccession":"Q9BXN2-6","geneName":"CLEC7A","intActId":"EBI-11989440"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q12983","intActId":"EBI-749464"},"interactantTwo":{"uniProtKBAccession":"Q96DZ9-2","geneName":"CMTM5","intActId":"EBI-11522780"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q12983","intActId":"EBI-749464"},"interactantTwo":{"uniProtKBAccession":"Q96BA8","geneName":"CREB3L1","intActId":"EBI-6942903"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q12983","intActId":"EBI-749464"},"interactantTwo":{"uniProtKBAccession":"O00559","geneName":"EBAG9","intActId":"EBI-8787095"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q12983","intActId":"EBI-749464"},"interactantTwo":{"uniProtKBAccession":"Q15125","geneName":"EBP","intActId":"EBI-3915253"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q12983","intActId":"EBI-749464"},"interactantTwo":{"uniProtKBAccession":"Q9GZR5","geneName":"ELOVL4","intActId":"EBI-18535450"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q12983","intActId":"EBI-749464"},"interactantTwo":{"uniProtKBAccession":"Q9Y282","geneName":"ERGIC3","intActId":"EBI-781551"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q12983","intActId":"EBI-749464"},"interactantTwo":{"uniProtKBAccession":"Q5JX71","geneName":"FAM209A","intActId":"EBI-18304435"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q12983","intActId":"EBI-749464"},"interactantTwo":{"uniProtKBAccession":"Q96D05-2","geneName":"FAM241B","intActId":"EBI-12118888"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q12983","intActId":"EBI-749464"},"interactantTwo":{"uniProtKBAccession":"Q92520","geneName":"FAM3C","intActId":"EBI-2876774"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q12983","intActId":"EBI-749464"},"interactantTwo":{"uniProtKBAccession":"Q969F0","geneName":"FATE1","intActId":"EBI-743099"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q12983","intActId":"EBI-749464"},"interactantTwo":{"uniProtKBAccession":"O15552","geneName":"FFAR2","intActId":"EBI-2833872"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q12983","intActId":"EBI-749464"},"interactantTwo":{"uniProtKBAccession":"Q8TDT2","geneName":"GPR152","intActId":"EBI-13345167"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q12983","intActId":"EBI-749464"},"interactantTwo":{"uniProtKBAccession":"O15529","geneName":"GPR42","intActId":"EBI-18076404"},"num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Colocalizes with ACAA2 in the mitochondria. Colocalizes with SPATA18 at the mitochondrion outer membrane"}]},"subcellularLocations":[{"location":{"value":"Mitochondrion","id":"SL-0173"}},{"location":{"value":"Mitochondrion outer membrane","id":"SL-0172"},"topology":{"value":"Single-pass membrane protein","id":"SL-9904"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the NIP3 family"}],"commentType":"SIMILARITY"},{"commentType":"WEB RESOURCE","resourceName":"Atlas of Genetics and Cytogenetics in Oncology and Haematology","resourceUrl":"https://atlasgeneticsoncology.org/gene/822/BNIP3","ftp":false}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":194,"modifier":"EXACT"}},"description":"BCL2/adenovirus E1B 19 kDa protein-interacting protein 3","featureId":"PRO_0000064964"},{"type":"Transmembrane","location":{"start":{"value":164,"modifier":"EXACT"},"end":{"value":184,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":102,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Motif","location":{"start":{"value":100,"modifier":"EXACT"},"end":{"value":125,"modifier":"EXACT"}},"description":"BH3"},{"type":"Compositional bias","location":{"start":{"value":42,"modifier":"EXACT"},"end":{"value":55,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":56,"modifier":"EXACT"},"end":{"value":69,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":78,"modifier":"EXACT"},"end":{"value":88,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":54,"modifier":"EXACT"},"end":{"value":54,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Modified residue","location":{"start":{"value":66,"modifier":"EXACT"},"end":{"value":66,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Modified residue","location":{"start":{"value":86,"modifier":"EXACT"},"end":{"value":86,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"}]},{"type":"Modified residue","location":{"start":{"value":92,"modifier":"EXACT"},"end":{"value":92,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O55003"}]},{"type":"Modified residue","location":{"start":{"value":95,"modifier":"EXACT"},"end":{"value":95,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Sequence conflict","location":{"start":{"value":3,"modifier":"EXACT"},"end":{"value":3,"modifier":"EXACT"}},"description":"in Ref. 1; 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