{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q13323","secondaryAccessions":["Q16582","Q6FH93"],"uniProtkbId":"BIK_HUMAN","entryAudit":{"firstPublicDate":"1997-11-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1997-11-01","entryVersion":190,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"7478623"}],"value":"Bcl-2-interacting killer"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"8816500"}],"value":"Apoptosis inducer NBK"}},{"fullName":{"value":"BIP1"}},{"fullName":{"value":"BP4"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"7478623"},{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:1051"}],"value":"BIK"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"8816500"}],"value":"NBK"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8521816"}],"value":"Accelerates programmed cell death. Association to the apoptosis repressors Bcl-X(L), BHRF1, Bcl-2 or its adenovirus homolog E1B 19k protein suppresses this death-promoting activity. Does not interact with BAX"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18953687"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23235460"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23563182"}],"value":"Interacts with RHBDL4/RHBDD1 (PubMed:18953687). Interacts with BCL2L10/BCL-B (PubMed:23235460, PubMed:23563182)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"Q9UHX3","geneName":"ADGRE2","intActId":"EBI-11277970"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"Q15848","geneName":"ADIPOQ","intActId":"EBI-10827839"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"Q9NVV5-2","geneName":"AIG1","intActId":"EBI-11957045"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"Q9BVK2","geneName":"ALG8","intActId":"EBI-3921603"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"Q86W74-2","geneName":"ANKRD46","intActId":"EBI-12109402"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"P05090","geneName":"APOD","intActId":"EBI-715495"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"Q8WVX3-2","geneName":"ARLN","intActId":"EBI-12003442"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"P10415","geneName":"BCL2","intActId":"EBI-77694"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"Q16548","geneName":"BCL2A1","intActId":"EBI-1003550"},"numberOfExperiments":10,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"A0A0S2Z3D2","geneName":"BCL2L1","intActId":"EBI-16431449"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"Q07817","geneName":"BCL2L1","intActId":"EBI-78035"},"numberOfExperiments":12,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"Q07817-1","geneName":"BCL2L1","intActId":"EBI-287195"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"Q9HD36","geneName":"BCL2L10","intActId":"EBI-2126349"},"numberOfExperiments":8,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"Q92843","geneName":"BCL2L2","intActId":"EBI-707714"},"numberOfExperiments":23,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"O95393","geneName":"BMP10","intActId":"EBI-3922513"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"Q12983","geneName":"BNIP3","intActId":"EBI-749464"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"Q6PL45-2","geneName":"BRICD5","intActId":"EBI-12244618"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"Q8WVV5","geneName":"BTN2A2","intActId":"EBI-8648738"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"O14523","geneName":"C2CD2L","intActId":"EBI-12822627"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"Q06432","geneName":"CACNG1","intActId":"EBI-9686780"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"P19397","geneName":"CD53","intActId":"EBI-6657396"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"P21854","geneName":"CD72","intActId":"EBI-307924"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"Q8N6F1-2","geneName":"CLDN19","intActId":"EBI-12256978"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"Q96DZ9-2","geneName":"CMTM5","intActId":"EBI-11522780"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"Q96FZ5","geneName":"CMTM7","intActId":"EBI-2807956"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"O95406","geneName":"CNIH1","intActId":"EBI-12172273"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"Q8TBE1","geneName":"CNIH3","intActId":"EBI-12208021"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"Q4LDR2","geneName":"CTXN3","intActId":"EBI-12019274"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"P49447","geneName":"CYB561","intActId":"EBI-8646596"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"O43169","geneName":"CYB5B","intActId":"EBI-1058710"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"Q9GZR5","geneName":"ELOVL4","intActId":"EBI-18535450"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"Q9Y282","geneName":"ERGIC3","intActId":"EBI-781551"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"Q2M3D2","geneName":"EXOC3L2","intActId":"EBI-14890134"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"Q5JX71","geneName":"FAM209A","intActId":"EBI-18304435"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"Q96D05-2","geneName":"FAM241B","intActId":"EBI-12118888"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"Q92520","geneName":"FAM3C","intActId":"EBI-2876774"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"Q969F0","geneName":"FATE1","intActId":"EBI-743099"},"numberOfExperiments":8,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"P12314","geneName":"FCGR1A","intActId":"EBI-2869867"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"Q8WWP7","geneName":"GIMAP1","intActId":"EBI-11991950"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"Q8TED1","geneName":"GPX8","intActId":"EBI-11721746"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"Q14416","geneName":"GRM2","intActId":"EBI-10232876"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"Q9Y5U4","geneName":"INSIG2","intActId":"EBI-8503746"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"O15554","geneName":"KCNN4","intActId":"EBI-2924473"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"Q9NX47","geneName":"MARCHF5","intActId":"EBI-2341610"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"Q5J8X5","geneName":"MS4A13","intActId":"EBI-12070086"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"Q9UHE5","geneName":"NAT8","intActId":"EBI-2863634"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"Q8N912","geneName":"NRAC","intActId":"EBI-12051377"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"Q8IXM6","geneName":"NRM","intActId":"EBI-10262547"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"Q96AL5","geneName":"PBX3","intActId":"EBI-741171"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"Q9UHJ9-5","geneName":"PGAP2","intActId":"EBI-12092917"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"O00264","geneName":"PGRMC1","intActId":"EBI-1045534"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"P26678","geneName":"PLN","intActId":"EBI-692836"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"P60201-2","geneName":"PLP1","intActId":"EBI-12188331"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"Q04941","geneName":"PLP2","intActId":"EBI-608347"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"Q5VZY2","geneName":"PLPP4","intActId":"EBI-10485931"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"Q9H6H4","geneName":"REEP4","intActId":"EBI-7545592"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"Q96GQ5","geneName":"RUSF1","intActId":"EBI-8636004"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"Q969E2","geneName":"SCAMP4","intActId":"EBI-4403649"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"Q96IW7","geneName":"SEC22A","intActId":"EBI-8652744"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"Q9Y6D0","geneName":"SELENOK","intActId":"EBI-9679163"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"Q9Y6X1","geneName":"SERP1","intActId":"EBI-10329948"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"Q8N6R1","geneName":"SERP2","intActId":"EBI-749270"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"Q8IWU4","geneName":"SLC30A8","intActId":"EBI-10262251"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"Q96G79","geneName":"SLC35A4","intActId":"EBI-12363689"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"Q7Z769","geneName":"SLC35E3","intActId":"EBI-13389236"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"O43826","geneName":"SLC37A4","intActId":"EBI-6269684"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"Q92504","geneName":"SLC39A7","intActId":"EBI-1051105"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"B2RUZ4","geneName":"SMIM1","intActId":"EBI-12188413"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"P0DN84","geneName":"STRIT1","intActId":"EBI-12200293"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"Q9UNK0","geneName":"STX8","intActId":"EBI-727240"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"Q969X1","geneName":"TMBIM1","intActId":"EBI-2820569"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"Q6UX40","geneName":"TMEM107","intActId":"EBI-12845616"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"P17152","geneName":"TMEM11","intActId":"EBI-723946"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"Q9BXJ8","geneName":"TMEM120A","intActId":"EBI-727322"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"Q9NUH8","geneName":"TMEM14B","intActId":"EBI-8638294"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"Q9P0S9","geneName":"TMEM14C","intActId":"EBI-2339195"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"Q9H0R3","geneName":"TMEM222","intActId":"EBI-347385"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"Q8NBD8","geneName":"TMEM229B","intActId":"EBI-12195227"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"Q9BU79","geneName":"TMEM243","intActId":"EBI-12887458"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"Q8TBM7","geneName":"TMEM254","intActId":"EBI-11956809"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"Q9H2L4","geneName":"TMEM60","intActId":"EBI-2852148"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"Q96HE8","geneName":"TMEM80","intActId":"EBI-11742770"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"Q8N661","geneName":"TMEM86B","intActId":"EBI-2548832"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"Q5BJF2","geneName":"TMEM97","intActId":"EBI-12111910"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"Q5TGU0","geneName":"TSPO2","intActId":"EBI-12195249"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"Q5BVD1","geneName":"TTMP","intActId":"EBI-10243654"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"A5PKU2","geneName":"TUSC5","intActId":"EBI-11988865"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"Q9Y5Z9","geneName":"UBIAD1","intActId":"EBI-2819725"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"Q15836","geneName":"VAMP3","intActId":"EBI-722343"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"O95183","geneName":"VAMP5","intActId":"EBI-10191195"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"Q9BQB6","geneName":"VKORC1","intActId":"EBI-6256462"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"Q8N511","geneName":"VMA12","intActId":"EBI-10265825"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13323","intActId":"EBI-700794"},"interactantTwo":{"uniProtKBAccession":"O95159","geneName":"ZFPL1","intActId":"EBI-718439"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8816500"}],"value":"Around the nuclear envelope, and in cytoplasmic membranes"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8816500"}],"value":"Endomembrane system","id":"SL-0147"},"topology":{"evidences":[{"evidenceCode":"ECO:0000255"}],"value":"Single-pass membrane protein","id":"SL-9904"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O70337"}],"value":"Mitochondrion membrane","id":"SL-0171"},"topology":{"evidences":[{"evidenceCode":"ECO:0000255"}],"value":"Single-pass membrane protein","id":"SL-9904"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8521816"}],"value":"Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18953687"}],"value":"Proteolytically cleaved by RHBDL4/RHBDD1. RHBDL4/RHBDD1-induced cleavage is a necessary step prior its degradation by the proteosome-dependent mechanism"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31387940"}],"value":"Ubiquitinated by the ECS(ASB11) complex in response to endoplasmic reticulum stress, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome"}],"commentType":"PTM"},{"commentType":"WEB RESOURCE","resourceName":"IDR Image Data Resource","resourceUrl":"https://idr.openmicroscopy.org/search/?key=Protein+URL&value=https%3A%2F%2Fwww.uniprot.org%2Funiprot%2FQ13323&operator=equals&resource=image","ftp":false}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":160,"modifier":"EXACT"}},"description":"Bcl-2-interacting killer","featureId":"PRO_0000143100"},{"type":"Transmembrane","location":{"start":{"value":136,"modifier":"EXACT"},"end":{"value":156,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Region","location":{"start":{"value":137,"modifier":"EXACT"},"end":{"value":158,"modifier":"EXACT"}},"description":"Leucine-zipper","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Motif","location":{"start":{"value":57,"modifier":"EXACT"},"end":{"value":71,"modifier":"EXACT"}},"description":"BH3","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8521816"}]},{"type":"Site","location":{"start":{"value":153,"modifier":"EXACT"},"end":{"value":154,"modifier":"EXACT"}},"description":"Cleavage; by RHBDL4/RHBDD1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18953687"}]},{"type":"Natural variant","location":{"start":{"value":19,"modifier":"EXACT"},"end":{"value":19,"modifier":"EXACT"}},"description":"in dbSNP:rs4988415","featureCrossReferences":[{"database":"dbSNP","id":"rs4988415"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.7"}],"featureId":"VAR_029179","alternativeSequence":{"originalSequence":"E","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":26,"modifier":"EXACT"},"end":{"value":26,"modifier":"EXACT"}},"description":"in dbSNP:rs11090143","featureCrossReferences":[{"database":"dbSNP","id":"rs11090143"}],"featureId":"VAR_048420","alternativeSequence":{"originalSequence":"T","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":148,"modifier":"EXACT"},"end":{"value":148,"modifier":"EXACT"}},"description":"in dbSNP:rs11574527","featureCrossReferences":[{"database":"dbSNP","id":"rs11574527"}],"featureId":"VAR_029180","alternativeSequence":{"originalSequence":"L","alternativeSequences":["P"]}},{"type":"Mutagenesis","location":{"start":{"value":153,"modifier":"EXACT"},"end":{"value":154,"modifier":"EXACT"}},"description":"Inhibits RHBDL4/RHBDD1-induced cleavage.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18953687"}],"alternativeSequence":{"originalSequence":"GG","alternativeSequences":["FF"]}}],"keywords":[{"id":"KW-0053","category":"Biological process","name":"Apoptosis"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"id":"KW-0832","category":"PTM","name":"Ubl conjugation"}],"references":[{"referenceNumber":1,"citation":{"id":"7478623","citationType":"journal article","authors":["Boyd J.M.","Gallo G.J.","Elangovan B.","Houghton A.B.","Malstrom S.","Avery B.J.","Ebb R.G.","Subramanian T.","Chittenden T.","Lutz R.J.","Chinnadurai G."],"citationCrossReferences":[{"database":"PubMed","id":"7478623"}],"title":"Bik, a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins.","publicationDate":"1995","journal":"Oncogene","firstPage":"1921","lastPage":"1928","volume":"11"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"],"referenceComments":[{"value":"B-cell","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"8816500","citationType":"journal article","authors":["Han J.","Sabbatini P.","White E."],"citationCrossReferences":[{"database":"PubMed","id":"8816500"},{"database":"DOI","id":"10.1128/mcb.16.10.5857"}],"title":"Induction of apoptosis by human Nbk/Bik, a BH3-containing protein that interacts with E1B 19K.","publicationDate":"1996","journal":"Mol. Cell. Biol.","firstPage":"5857","lastPage":"5864","volume":"16"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]","SUBCELLULAR LOCATION"]},{"referenceNumber":3,"citation":{"id":"CI-BN45BJIC994VS","citationType":"submission","authors":["Pun K.-T.","Farrow S.N.","Raven T.","Wride C.J.","White J.H.M.","Brown R."],"title":"E1B-19K interacts with a novel apoptotic inducer, NBK.","publicationDate":"JUL-1995","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"],"referenceComments":[{"value":"Lymphoid tissue","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"10500065","citationType":"journal article","authors":["Castells A.","Ino Y.","Louis D.N.","Ramesh V.","Gusella J.F.","Rustgi A.K."],"citationCrossReferences":[{"database":"PubMed","id":"10500065"},{"database":"DOI","id":"10.1016/s0016-5085(99)70341-0"}],"title":"Mapping of a target region of allelic loss to a 0.5-cM interval on chromosome 22q13 in human colorectal cancer.","publicationDate":"1999","journal":"Gastroenterology","firstPage":"831","lastPage":"837","volume":"117"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":5,"citation":{"id":"15461802","citationType":"journal article","authors":["Collins J.E.","Wright C.L.","Edwards C.A.","Davis M.P.","Grinham J.A.","Cole C.G.","Goward M.E.","Aguado B.","Mallya M.","Mokrab Y.","Huckle E.J.","Beare D.M.","Dunham I."],"citationCrossReferences":[{"database":"PubMed","id":"15461802"},{"database":"DOI","id":"10.1186/gb-2004-5-10-r84"}],"title":"A genome annotation-driven approach to cloning the human ORFeome.","publicationDate":"2004","journal":"Genome Biol.","firstPage":"R84.1","lastPage":"R84.11","volume":"5"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"]},{"referenceNumber":6,"citation":{"id":"CI-54UTT6AFSFO1R","citationType":"submission","authors":["Kalnine N.","Chen X.","Rolfs A.","Halleck A.","Hines L.","Eisenstein S.","Koundinya M.","Raphael J.","Moreira D.","Kelley T.","LaBaer J.","Lin Y.","Phelan M.","Farmer A."],"title":"Cloning of human full-length CDSs in BD Creator(TM) system donor vector.","publicationDate":"OCT-2004","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"]},{"referenceNumber":7,"citation":{"id":"CI-9GAL69OSTBTVD","citationType":"submission","authoringGroup":["NIEHS SNPs program"],"publicationDate":"FEB-2003","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]","VARIANT LYS-19"]},{"referenceNumber":8,"citation":{"id":"CI-D49P6QQO8F5LU","citationType":"submission","authors":["Ebert L.","Schick M.","Neubert P.","Schatten R.","Henze S.","Korn B."],"title":"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201).","publicationDate":"JUN-2004","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"]},{"referenceNumber":9,"citation":{"id":"10591208","citationType":"journal article","authors":["Dunham I.","Hunt A.R.","Collins J.E.","Bruskiewich R.","Beare D.M.","Clamp M.","Smink L.J.","Ainscough R.","Almeida J.P.","Babbage A.K.","Bagguley C.","Bailey J.","Barlow K.F.","Bates K.N.","Beasley O.P.","Bird C.P.","Blakey S.E.","Bridgeman A.M.","Buck D.","Burgess J.","Burrill W.D.","Burton J.","Carder C.","Carter N.P.","Chen Y.","Clark G.","Clegg S.M.","Cobley V.E.","Cole C.G.","Collier R.E.","Connor R.","Conroy D.","Corby N.R.","Coville G.J.","Cox A.V.","Davis J.","Dawson E.","Dhami P.D.","Dockree C.","Dodsworth S.J.","Durbin R.M.","Ellington A.G.","Evans K.L.","Fey J.M.","Fleming K.","French L.","Garner A.A.","Gilbert J.G.R.","Goward M.E.","Grafham D.V.","Griffiths M.N.D.","Hall C.","Hall R.E.","Hall-Tamlyn G.","Heathcott R.W.","Ho S.","Holmes S.","Hunt S.E.","Jones M.C.","Kershaw J.","Kimberley A.M.","King A.","Laird G.K.","Langford C.F.","Leversha M.A.","Lloyd C.","Lloyd D.M.","Martyn I.D.","Mashreghi-Mohammadi M.","Matthews L.H.","Mccann O.T.","Mcclay J.","Mclaren S.","McMurray A.A.","Milne S.A.","Mortimore B.J.","Odell C.N.","Pavitt R.","Pearce A.V.","Pearson D.","Phillimore B.J.C.T.","Phillips S.H.","Plumb R.W.","Ramsay H.","Ramsey Y.","Rogers L.","Ross M.T.","Scott C.E.","Sehra H.K.","Skuce C.D.","Smalley S.","Smith M.L.","Soderlund C.","Spragon L.","Steward C.A.","Sulston J.E.","Swann R.M.","Vaudin M.","Wall M.","Wallis J.M.","Whiteley M.N.","Willey D.L.","Williams L.","Williams S.A.","Williamson H.","Wilmer T.E.","Wilming L.","Wright C.L.","Hubbard T.","Bentley D.R.","Beck S.","Rogers J.","Shimizu N.","Minoshima S.","Kawasaki K.","Sasaki T.","Asakawa S.","Kudoh J.","Shintani A.","Shibuya K.","Yoshizaki Y.","Aoki N.","Mitsuyama S.","Roe B.A.","Chen F.","Chu L.","Crabtree J.","Deschamps S.","Do A.","Do T.","Dorman A.","Fang F.","Fu Y.","Hu P.","Hua A.","Kenton S.","Lai H.","Lao H.I.","Lewis J.","Lewis S.","Lin S.-P.","Loh P.","Malaj E.","Nguyen T.","Pan H.","Phan S.","Qi S.","Qian Y.","Ray L.","Ren Q.","Shaull S.","Sloan D.","Song L.","Wang Q.","Wang Y.","Wang Z.","White J.","Willingham D.","Wu H.","Yao Z.","Zhan M.","Zhang G.","Chissoe S.","Murray J.","Miller N.","Minx P.","Fulton R.","Johnson D.","Bemis G.","Bentley D.","Bradshaw H.","Bourne S.","Cordes M.","Du Z.","Fulton L.","Goela D.","Graves T.","Hawkins J.","Hinds K.","Kemp K.","Latreille P.","Layman D.","Ozersky P.","Rohlfing T.","Scheet P.","Walker C.","Wamsley A.","Wohldmann P.","Pepin K.","Nelson J.","Korf I.","Bedell J.A.","Hillier L.W.","Mardis E.","Waterston R.","Wilson R.","Emanuel B.S.","Shaikh T.","Kurahashi H.","Saitta S.","Budarf M.L.","McDermid H.E.","Johnson A.","Wong A.C.C.","Morrow B.E.","Edelmann L.","Kim U.J.","Shizuya H.","Simon M.I.","Dumanski J.P.","Peyrard M.","Kedra D.","Seroussi E.","Fransson I.","Tapia I.","Bruder C.E.","O'Brien K.P.","Wilkinson P.","Bodenteich A.","Hartman K.","Hu X.","Khan A.S.","Lane L.","Tilahun Y.","Wright H."],"citationCrossReferences":[{"database":"PubMed","id":"10591208"},{"database":"DOI","id":"10.1038/990031"}],"title":"The DNA sequence of human chromosome 22.","publicationDate":"1999","journal":"Nature","firstPage":"489","lastPage":"495","volume":"402"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":10,"citation":{"id":"CI-5GBDQ6B103N1E","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"JUL-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":11,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Lymph","type":"TISSUE"}]},{"referenceNumber":12,"citation":{"id":"8521816","citationType":"journal article","authors":["Chittenden T.","Flemington C.","Houghton A.B.","Ebb R.G.","Gallo G.J.","Elangovan B.","Chinnadurai G.","Lutz R.J."],"citationCrossReferences":[{"database":"PubMed","id":"8521816"},{"database":"DOI","id":"10.1002/j.1460-2075.1995.tb00246.x"}],"title":"A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions.","publicationDate":"1995","journal":"EMBO J.","firstPage":"5589","lastPage":"5596","volume":"14"},"referencePositions":["MUTAGENESIS","FUNCTION OF BH3 MOTIF"]},{"referenceNumber":13,"citation":{"id":"18953687","citationType":"journal article","authors":["Wang Y.","Guan X.","Fok K.L.","Li S.","Zhang X.","Miao S.","Zong S.","Koide S.S.","Chan H.C.","Wang L."],"citationCrossReferences":[{"database":"PubMed","id":"18953687"},{"database":"DOI","id":"10.1007/s00018-008-8452-0"}],"title":"A novel member of the Rhomboid family, RHBDD1, regulates BIK-mediated apoptosis.","publicationDate":"2008","journal":"Cell. Mol. Life Sci.","firstPage":"3822","lastPage":"3829","volume":"65"},"referencePositions":["CLEAVAGE BY RHBDD1","INTERACTION WITH RHBDD1","MUTAGENESIS OF 153-GLY-PHE-154"]},{"referenceNumber":14,"citation":{"id":"23235460","citationType":"journal article","authors":["Rautureau G.J.","Yabal M.","Yang H.","Huang D.C.","Kvansakul M.","Hinds M.G."],"citationCrossReferences":[{"database":"PubMed","id":"23235460"},{"database":"DOI","id":"10.1038/cddis.2012.178"}],"title":"The restricted binding repertoire of Bcl-B leaves Bim as the universal BH3-only prosurvival Bcl-2 protein antagonist.","publicationDate":"2012","journal":"Cell Death Dis.","firstPage":"e443","lastPage":"e443","volume":"3"},"referencePositions":["INTERACTION WITH BCL2L10"]},{"referenceNumber":15,"citation":{"id":"23563182","citationType":"journal article","authors":["van de Kooij B.","Rooswinkel R.W.","Kok F.","Herrebout M.","de Vries E.","Paauwe M.","Janssen G.M.","van Veelen P.A.","Borst J."],"citationCrossReferences":[{"database":"PubMed","id":"23563182"},{"database":"DOI","id":"10.1038/onc.2013.99"}],"title":"Polyubiquitination and proteasomal turnover controls the anti-apoptotic activity of Bcl-B.","publicationDate":"2013","journal":"Oncogene","firstPage":"5439","lastPage":"5448","volume":"32"},"referencePositions":["INTERACTION WITH BCL2L10"]},{"referenceNumber":16,"citation":{"id":"31387940","citationType":"journal article","authors":["Chen F.Y.","Huang M.Y.","Lin Y.M.","Ho C.H.","Lin S.Y.","Chen H.Y.","Hung M.C.","Chen R.H."],"citationCrossReferences":[{"database":"PubMed","id":"31387940"},{"database":"DOI","id":"10.1083/jcb.201901156"}],"title":"BIK ubiquitination by the E3 ligase Cul5-ASB11 determines cell fate during cellular stress.","publicationDate":"2019","journal":"J. Cell Biol.","firstPage":"3002","lastPage":"3018","volume":"218"},"referencePositions":["UBIQUITINATION"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"U34584","properties":[{"key":"ProteinId","value":"AAC50413.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"U49730","properties":[{"key":"ProteinId","value":"AAC79124.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"X89986","properties":[{"key":"ProteinId","value":"CAA62013.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF174424","properties":[{"key":"ProteinId","value":"AAF01156.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF174421","properties":[{"key":"ProteinId","value":"AAF01156.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF174422","properties":[{"key":"ProteinId","value":"AAF01156.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF174423","properties":[{"key":"ProteinId","value":"AAF01156.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CR456390","properties":[{"key":"ProteinId","value":"CAG30276.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BT006728","properties":[{"key":"ProteinId","value":"AAP35374.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AY245248","properties":[{"key":"ProteinId","value":"AAO61089.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CR541863","properties":[{"key":"ProteinId","value":"CAG46661.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"CR541883","properties":[{"key":"ProteinId","value":"CAG46681.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AL022237","properties":[{"key":"ProteinId","value":"CAA18260.2"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471138","properties":[{"key":"ProteinId","value":"EAW73282.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC001599","properties":[{"key":"ProteinId","value":"AAH01599.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS14044.1","properties":[{"key":"Description","value":"-"}]},{"database":"PIR","id":"S58214","properties":[{"key":"EntryName","value":"S58214"}]},{"database":"RefSeq","id":"NP_001188.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001197.5"}]},{"database":"AlphaFoldDB","id":"Q13323","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"107107","properties":[{"key":"Interactions","value":"131"}]},{"database":"ComplexPortal","id":"CPX-309","properties":[{"key":"EntryName","value":"BIK:BCL-w complex"}]},{"database":"DIP","id":"DIP-928N","properties":[{"key":"Description","value":"-"}]},{"database":"ELM","id":"Q13323","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q13323","properties":[{"key":"Number of interactors","value":"6"}]},{"database":"IntAct","id":"Q13323","properties":[{"key":"Interactions","value":"104"}]},{"database":"MINT","id":"Q13323","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-BIK","properties":[{"key":"Evidences","value":"3 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000216115","properties":[{"key":"Description","value":"-"}]},{"database":"iPTMnet","id":"Q13323","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q13323","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"BIK","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"2493284","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q13323","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q13323","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000216115","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q13323","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"59311","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"13376","properties":[{"key":"antibodies","value":"537 antibodies from 39 providers"}]},{"database":"DNASU","id":"638","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000216115.3","properties":[{"key":"ProteinId","value":"ENSP00000216115.2"},{"key":"GeneId","value":"ENSG00000100290.4"}]},{"database":"Ensembl","id":"ENST00000910665.1","properties":[{"key":"ProteinId","value":"ENSP00000580724.1"},{"key":"GeneId","value":"ENSG00000100290.4"}]},{"database":"Ensembl","id":"ENST00000910667.1","properties":[{"key":"ProteinId","value":"ENSP00000580726.1"},{"key":"GeneId","value":"ENSG00000100290.4"}]},{"database":"Ensembl","id":"ENST00000910669.1","properties":[{"key":"ProteinId","value":"ENSP00000580729.1"},{"key":"GeneId","value":"ENSG00000100290.4"}]},{"database":"Ensembl","id":"ENST00000956707.1","properties":[{"key":"ProteinId","value":"ENSP00000626766.1"},{"key":"GeneId","value":"ENSG00000100290.4"}]},{"database":"GeneID","id":"638","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:638","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000216115.3","properties":[{"key":"ProteinId","value":"ENSP00000216115.2"},{"key":"RefSeqNucleotideId","value":"NM_001197.5"},{"key":"RefSeqProteinId","value":"NP_001188.1"}]},{"database":"UCSC","id":"uc003bdk.3","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:1051","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA25354","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"638","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"638","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"BIK","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:1051","properties":[{"key":"GeneName","value":"BIK"}]},{"database":"HPA","id":"ENSG00000100290","properties":[{"key":"ExpressionPatterns","value":"Tissue enhanced (salivary)"}]},{"database":"MIM","id":"603392","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000100290","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000100290","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502TF5K","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00530000064453","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_139842_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q13323","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"ECMEGSD","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9799917at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q13323","properties":[{"key":"Number of GO annotations","value":"2 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q13323","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q13323","properties":[{"key":"Description","value":"-"}]},{"database":"SignaLink","id":"Q13323","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"Q13323","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000100290","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"638","properties":[{"key":"hits","value":"12 hits in 1144 CRISPR screens"}]},{"database":"ChiTaRS","id":"BIK","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GeneWiki","id":"Bcl-2-interacting_killer","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"638","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q13323","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:Q13323","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 22"}]},{"database":"RNAct","id":"Q13323","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000100290","properties":[{"key":"ExpressionPatterns","value":"Expressed in nasal cavity epithelium and 130 other cell types or tissues"}]},{"database":"GO","id":"GO:0097136","properties":[{"key":"GoTerm","value":"C:Bcl-2 family protein complex"},{"key":"GoEvidenceType","value":"IPI:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"15694340"}]},{"database":"GO","id":"GO:0012505","properties":[{"key":"GoTerm","value":"C:endomembrane system"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8816500"}]},{"database":"GO","id":"GO:0031966","properties":[{"key":"GoTerm","value":"C:mitochondrial membrane"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0008637","properties":[{"key":"GoTerm","value":"P:apoptotic mitochondrial changes"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0006915","properties":[{"key":"GoTerm","value":"P:apoptotic process"},{"key":"GoEvidenceType","value":"TAS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"10381623"}]},{"database":"GO","id":"GO:0008584","properties":[{"key":"GoTerm","value":"P:male gonad development"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0031334","properties":[{"key":"GoTerm","value":"P:positive regulation of protein-containing complex assembly"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"21041309"}]},{"database":"GO","id":"GO:0090200","properties":[{"key":"GoTerm","value":"P:positive regulation of release of cytochrome c from mitochondria"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"21041309"}]},{"database":"GO","id":"GO:0042981","properties":[{"key":"GoTerm","value":"P:regulation of apoptotic process"},{"key":"GoEvidenceType","value":"IDA:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16697956"}]},{"database":"InterPro","id":"IPR024579","properties":[{"key":"EntryName","value":"Bcl2-int_killer"}]},{"database":"InterPro","id":"IPR020728","properties":[{"key":"EntryName","value":"Bcl2_BH3_motif_CS"}]},{"database":"PANTHER","id":"PTHR15018","properties":[{"key":"EntryName","value":"BCL-2-INTERACTING KILLER"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR15018:SF1","properties":[{"key":"EntryName","value":"BCL-2-INTERACTING KILLER"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF12201","properties":[{"key":"EntryName","value":"bcl-2I13"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01259","properties":[{"key":"EntryName","value":"BH3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSEVRPLSRDILMETLLYEQLLEPPTMEVLGMTDSEEDLDPMEDFDSLECMEGSDALALRLACIGDEMDVSLRAPRLAQLSEVAMHSLGLAFIYDQTEDIRDVLRSFMDGFTTLKENIMRFWRSPNPGSWVSCEQVLLALLLLLALLLPLLSGGLHLLLK","length":160,"molWeight":18016,"crc64":"89034F4443F5A136","md5":"3584D655FFBE11A4692FDECB51080717"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"INTERACTION":93,"SUBCELLULAR LOCATION":1,"DOMAIN":1,"PTM":2,"WEB RESOURCE":1},"countByFeatureType":{"Chain":1,"Transmembrane":1,"Region":1,"Motif":1,"Site":1,"Natural variant":3,"Mutagenesis":1},"uniParcId":"UPI000000D929"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8SWR1","uniProtkbId":"A0ACI8SWR1_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000588111.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000588111.1"}],"value":"BCL2 interacting killer"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000588111.1"}],"value":"BIK"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004370"}],"value":"Membrane","id":"SL-0162"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004173"}],"value":"Mitochondrion","id":"SL-0173"}}]}],"features":[{"type":"Transmembrane","location":{"start":{"value":174,"modifier":"EXACT"},"end":{"value":197,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022703"}],"id":"KW-0053","category":"Biological process","name":"Apoptosis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023128"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8SWR1"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8SWR1"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000588111.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000588111.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"18477386","citationType":"journal article","authors":["Cole C.G.","McCann O.T.","Collins J.E.","Oliver K.","Willey D.","Gribble S.M.","Yang F.","McLaren K.","Rogers J.","Ning Z.","Beare D.M.","Dunham I."],"citationCrossReferences":[{"database":"PubMed","id":"18477386"},{"database":"DOI","id":"10.1186/gb-2008-9-5-r78"}],"title":"Finishing the finished human chromosome 22 sequence.","publicationDate":"2008","journal":"Genome Biol.","firstPage":"R78","lastPage":"R78","volume":"9"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000588111.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000588111.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL022237","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000918052.1","properties":[{"key":"ProteinId","value":"ENSP00000588111.1"},{"key":"GeneId","value":"ENSG00000100290.4"}]},{"database":"HGNC","id":"HGNC:1051","properties":[{"key":"GeneName","value":"BIK"}]},{"database":"OpenTargets","id":"ENSG00000100290","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00530000064453","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 22"}]},{"database":"InterPro","id":"IPR024579","properties":[{"key":"EntryName","value":"Bcl2-int_killer"}]},{"database":"InterPro","id":"IPR020728","properties":[{"key":"EntryName","value":"Bcl2_BH3_motif_CS"}]},{"database":"PANTHER","id":"PTHR15018","properties":[{"key":"EntryName","value":"BCL-2-INTERACTING KILLER"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR15018:SF1","properties":[{"key":"EntryName","value":"BCL-2-INTERACTING KILLER"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF12201","properties":[{"key":"EntryName","value":"bcl-2I13"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS01259","properties":[{"key":"EntryName","value":"BH3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSEVRPLSRDILMETLLYEQLLEPPTMEVLGMTDSEEDLDPMEDFDSLECMEGSDALALRLACIGDEMDVSLRAPRLAQLSEVAMHSSGRQGQTPGGLAGGWLAEEAGSWNEFDHKQSIPRGPCSLGLAFIYDQTEDIRDVLRSFMDGFTTLKENIMRFWRSPNPGSWVSCEQVLLALLLLLALLLPLLSGGLHLLLK","length":198,"molWeight":21967,"crc64":"6755977525086419","md5":"0AED1C99989299F560DFF3F6319EF878"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Transmembrane":1},"uniParcId":"UPI0040316344"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8SWS4","uniProtkbId":"A0ACI8SWS4_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000588110.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000588110.1"}],"value":"BCL2 interacting killer"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000588110.1"}],"value":"BIK"}}],"features":[{"type":"Transmembrane","location":{"start":{"value":103,"modifier":"EXACT"},"end":{"value":126,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8SWS4"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8SWS4"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000588110.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000588110.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"18477386","citationType":"journal article","authors":["Cole C.G.","McCann O.T.","Collins J.E.","Oliver K.","Willey D.","Gribble S.M.","Yang F.","McLaren K.","Rogers J.","Ning Z.","Beare D.M.","Dunham I."],"citationCrossReferences":[{"database":"PubMed","id":"18477386"},{"database":"DOI","id":"10.1186/gb-2008-9-5-r78"}],"title":"Finishing the finished human chromosome 22 sequence.","publicationDate":"2008","journal":"Genome Biol.","firstPage":"R78","lastPage":"R78","volume":"9"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000588110.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000588110.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL022237","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000918051.1","properties":[{"key":"ProteinId","value":"ENSP00000588110.1"},{"key":"GeneId","value":"ENSG00000100290.4"}]},{"database":"HGNC","id":"HGNC:1051","properties":[{"key":"GeneName","value":"BIK"}]},{"database":"OpenTargets","id":"ENSG00000100290","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00530000064453","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 22"}]},{"database":"InterPro","id":"IPR024579","properties":[{"key":"EntryName","value":"Bcl2-int_killer"}]},{"database":"PANTHER","id":"PTHR15018","properties":[{"key":"EntryName","value":"BCL-2-INTERACTING KILLER"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR15018:SF1","properties":[{"key":"EntryName","value":"BCL-2-INTERACTING KILLER"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF12201","properties":[{"key":"EntryName","value":"bcl-2I13"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MSEVRPLSRDILMETLLYEQLLEPPTMEVLGMTDSEEDLDPMEDFDSLECMEGSLGLAFIYDQTEDIRDVLRSFMDGFTTLKENIMRFWRSPNPGSWVSCEQVLLALLLLLALLLPLLSGGLHLLLK","length":127,"molWeight":14481,"crc64":"42ACB62331C1701A","md5":"1886C7E69DFAB04C0FF3D717E1892CE9"},"extraAttributes":{"countByFeatureType":{"Transmembrane":1},"uniParcId":"UPI004031B93C"}}]}