{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9UQB8","secondaryAccessions":["O43858","Q53HB1","Q86WC1","Q8N5C0","Q96CR7","Q9UBR3","Q9UQ43"],"uniProtkbId":"BAIP2_HUMAN","entryAudit":{"firstPublicDate":"2005-08-30","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2000-05-01","entryVersion":214,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:947"}],"value":"BAR/IMD domain-containing adapter protein 2"}},"alternativeNames":[{"fullName":{"value":"Brain-specific angiogenesis inhibitor 1-associated protein 2"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"10343108"}],"value":"BAI-associated protein 2"},{"value":"BAI1-associated protein 2"},{"value":"Protein BAP2"}]},{"fullName":{"value":"Fas ligand-associated factor 3"},"shortNames":[{"value":"FLAF3"}]},{"fullName":{"value":"Insulin receptor substrate p53/p58"},"shortNames":[{"value":"IRS-58"},{"value":"IRSp53/58"}]},{"fullName":{"value":"Insulin receptor substrate protein of 53 kDa"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11130076"}],"value":"IRSp53"},{"value":"Insulin receptor substrate p53"}]}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"10343108"},{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:947"}],"value":"BAIAP2"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11130076"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11696321"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14752106"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17115031"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19366662"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"41133935"}],"value":"Adapter protein that links membrane-bound small G proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth, neuronal differentiation and neuronal migration (PubMed:41133935). Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions (PubMed:41133935)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10332026"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10343108"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11130076"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11157984"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11696321"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12504591"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15289329"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17115031"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19286134"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19366662"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38149472"}],"value":"Homodimer (PubMed:38149472). Interacts with CDC42 and RAC1 that have been activated by GTP binding. Interacts with ATN1, ADGRB1, EPS8, SHANK1, SHANK2, SHANK3, WASF1 and WASF2. Interacts with ENAH after recruitment of CDC42. Interacts with TIAM1 and DIAPH1 (By similarity). Interacts (via SH3 domain) with E.coli effector protein EspF(U) (via PXXP motifs). Interacts with E.coli intimin receptor 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Detected in filopodia and close to membrane ruffles. Recruited to actin pedestals that are formed upon infection by bacteria at bacterial attachment sites"}]},"subcellularLocations":[{"location":{"value":"Cytoplasm","id":"SL-0086"}},{"location":{"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38149472"}],"value":"Peripheral membrane protein","id":"SL-9903"}},{"location":{"value":"Cell projection, filopodium","id":"SL-0286"}},{"location":{"value":"Cell projection, ruffle","id":"SL-0300"}},{"location":{"value":"Cytoplasm, cytoskeleton","id":"SL-0090"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"synonyms":[{"value":"IRSp53(L)"}],"isoformIds":["Q9UQB8-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q9UQB8-2"],"sequenceIds":["VSP_015506"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"isoformIds":["Q9UQB8-3"],"sequenceIds":["VSP_015505"],"isoformSequenceStatus":"Described"},{"name":{"value":"4"},"synonyms":[{"value":"BAIAP2-alpha"}],"isoformIds":["Q9UQB8-4"],"sequenceIds":["VSP_015503"],"isoformSequenceStatus":"Described"},{"name":{"value":"5"},"synonyms":[{"value":"BAIAP2-beta"}],"isoformIds":["Q9UQB8-5"],"sequenceIds":["VSP_015504"],"isoformSequenceStatus":"Described"},{"name":{"value":"6"},"isoformIds":["Q9UQB8-6"],"sequenceIds":["VSP_015502","VSP_015503"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10332026"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10343108"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11157984"}],"value":"Isoform 1 and isoform 4 are expressed almost exclusively in brain. Isoform 4 is barely detectable in placenta, prostate and testis. A short isoform is ubiquitous, with the highest expression in liver, prostate, testis and placenta"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14752106"}],"value":"The IMD domain forms a coiled coil. The isolated domain can induce actin bundling and filopodia formation. In the absence of G-proteins intramolecular interaction between the IMD and the SH3 domain gives rise to an auto-inhibited state of the protein. 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