{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q99933","secondaryAccessions":["O75315","Q14414","Q53H32","Q5VZE8","Q5VZE9","Q5VZF0","Q96TG2","Q9Y2V4"],"uniProtkbId":"BAG1_HUMAN","entryAudit":{"firstPublicDate":"1997-11-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2010-05-18","entryVersion":232,"sequenceVersion":4},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"BAG family molecular chaperone regulator 1"},"shortNames":[{"value":"BAG-1"}]},"alternativeNames":[{"fullName":{"value":"Bcl-2-associated athanogene 1"}}]},"genes":[{"geneName":{"value":"BAG1"},"synonyms":[{"value":"HAP"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"B0K019"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12724406"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24318877"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27474739"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9305631"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9873016"}],"value":"Co-chaperone for HSP70 and HSC70 chaperone proteins. 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Involved in the STUB1-mediated proteasomal degradation of ESR1 in response to age-related circulating estradiol (17-beta-estradiol/E2) decline, thereby promotes neuronal apoptosis in response to ischemic reperfusion injury (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"B0K019"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q60739"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10477749"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11222862"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12724406"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15986447"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24318877"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27474739"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9305631"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9582267"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9679980"}],"value":"Homodimer. 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